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name Structure Reference Source Properties Activities Metabolism

3-{[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]methyl}-8-oxo-7-[2-(1H-1,2,3,4-tetrazol-1-yl)acetamido]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

AlkaPlorer ID: AK013485

Synonym: 'MLS001049010', 'CEFAZOLIN SODIUM SALT', 'MLS001032060', 'SMR000058708', 'MLS000028706', 'SMR000387025'

IUPAC Name: (6R,7R)-3-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanylmethyl]-8-oxo-7-[[2-(tetrazol-1-yl)acetyl]amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

Structure

SMILES: CC1=NN=C(SCC2=C(C(=O)O)N3C(=O)[C@@H](NC(=O)CN4C=NN=N4)[C@H]3SC2)S1

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InChI: InChI=1S/C14H14N8O4S3/c1-6-17-18-14(29-6)28-4-7-3-27-12-9(11(24)22(12)10(7)13(25)26)16-8(23)2-21-5-15-19-20-21/h5,9,12H,2-4H2,1H3,(H,16,23)(H,25,26)/t9-,12-/m1/s1

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InChIKey: MLYYVTUWGNIJIB-BXKDBHETSA-N

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Properties Information

Molecule Weight: 454.5190000000002

TPSA？: 156.08999999999995

MolLogP？: -0.6360799999999995

Number of H-Donors: 2

Number of H-Acceptors: 12

RingCount: 4

Activities Information

Organism Target Name Standard Type Standard Value Standard Units doi
Acinetobacter baumannii Acinetobacter baumannii MIC 64.0 ug.mL-1 10.1128/aac.00400-09
Acinetobacter baumannii Acinetobacter baumannii MIC 128.0 ug.mL-1 10.1128/aac.00393-08
Acinetobacter baumannii Acinetobacter baumannii MIC nan None 10.1128/aac.00393-08
Acinetobacter baumannii Acinetobacter baumannii MIC50 128.0 ug.mL-1 10.1128/aac.00400-09
Acinetobacter baumannii Acinetobacter baumannii MIC90 128.0 ug.mL-1 10.1128/aac.00400-09
Aeromonas caviae Aeromonas caviae MIC 1024.0 ug.mL-1 10.1128/aac.01462-06
Bacillus subtilis 4'-phosphopantetheinyl transferase ffp Potency 44668.4 nM None
Bacillus subtilis Bacillus subtilis MIC 0.063 ug.mL-1 10.1016/j.ejmech.2019.111744
Bacillus thuringiensis Bacillus thuringiensis MIC 0.063 ug.mL-1 10.1016/j.ejmech.2019.111744
Bacteroides fragilis Bacteroides fragilis Activity nan None 10.1021/jm00207a022
Canis lupus familiaris Canis familiaris CL 0.066 mL.min-1.kg-1 10.1124/dmd.112.049312
Canis lupus familiaris Canis familiaris CL 0.089 mL.min-1.kg-1 10.1124/dmd.112.049312
Chryseobacterium indologenes Chryseobacterium indologenes Activity 64.0 ug ml-1 10.1128/aac.00083-07
Clostridium perfringens Clostridium perfringens Activity nan None 10.1021/jm00207a022
Enterobacter cloacae Enterobacter cloacae Activity 3.6 % 10.1128/aac.00400-09
Enterobacter cloacae Enterobacter cloacae Activity 5.4 % 10.1128/aac.00400-09
Enterobacter cloacae Enterobacter cloacae Activity 83.3 % 10.1128/aac.01538-07
Enterobacter cloacae Enterobacter cloacae Activity 88.9 % 10.1128/aac.01538-07
Enterobacter cloacae Enterobacter cloacae Activity 89.7 % 10.1128/aac.01538-07
Enterobacter cloacae Enterobacter cloacae Activity 91.0 % 10.1128/aac.00400-09
Enterobacter cloacae Enterobacter cloacae Activity 94.1 % 10.1128/aac.01538-07
Enterobacter cloacae Enterobacter cloacae Activity 100.0 % 10.1128/aac.01538-07
Enterobacter cloacae Enterobacter cloacae MIC 1.0 ug.mL-1 10.1128/aac.00400-09
Enterobacter cloacae Enterobacter cloacae MIC 50.0 ug.mL-1 10.1021/jm00207a022
Enterobacter cloacae Enterobacter cloacae MIC50 128.0 ug.mL-1 10.1128/aac.00400-09
Enterobacter cloacae Enterobacter cloacae MIC90 128.0 ug.mL-1 10.1128/aac.00400-09
Enterococcus faecalis Enterococcus faecalis MIC 0.5 ug.mL-1 10.1128/aac.00400-09
Enterococcus faecalis Enterococcus faecalis MIC 13.0 ug.mL-1 10.1021/jm00211a006
Enterococcus faecalis Enterococcus faecalis MIC 100.0 ug.mL-1 10.1021/jm00207a022
Enterococcus faecalis Enterococcus faecalis MIC50 32.0 ug.mL-1 10.1128/aac.00400-09
Enterococcus faecalis Enterococcus faecalis MIC90 128.0 ug.mL-1 10.1128/aac.00400-09
Enterococcus faecium Enterococcus faecium MIC 32.0 ug.mL-1 10.1128/aac.00400-09
Enterococcus faecium Enterococcus faecium MIC 8132.0 ug.mL-1 10.1016/j.bmc.2021.116128
Enterococcus faecium Enterococcus faecium MIC50 128.0 ug.mL-1 10.1128/aac.00400-09
Enterococcus faecium Enterococcus faecium MIC90 128.0 ug.mL-1 10.1128/aac.00400-09
Enterococcus sp. Enterococcus sp. Activity nan None 10.1128/aac.01538-07
Escherichia coli Escherichia coli Activity 0.0 % 10.1128/aac.00551-10
Escherichia coli Escherichia coli Activity 1.0 ug ml-1 10.1128/aac.00083-07
Escherichia coli Escherichia coli Activity 1.1 % 10.1128/aac.00551-10
Escherichia coli Escherichia coli Activity 3.8 % 10.1128/aac.00400-09
Escherichia coli Escherichia coli Activity 8.6 % 10.1128/aac.01538-07
Escherichia coli Escherichia coli Activity 11.5 % 10.1128/aac.01538-07
Escherichia coli Escherichia coli Activity 14.1 % 10.1128/aac.00400-09
Escherichia coli Escherichia coli Activity 20.1 % 10.1128/aac.01538-07
Escherichia coli Escherichia coli Activity 21.9 % 10.1128/aac.01538-07
Escherichia coli Escherichia coli Activity 25.8 % 10.1128/aac.01538-07
Escherichia coli Escherichia coli Activity 64.0 ug ml-1 10.1128/aac.00083-07
Escherichia coli Escherichia coli Activity 82.1 % 10.1128/aac.00400-09
Escherichia coli Escherichia coli Activity 100.0 % 10.1128/aac.01412-06
Escherichia coli Escherichia coli Activity nan None 10.1128/aac.00043-09
Escherichia coli Escherichia coli ED50 0.6 mg.kg-1 10.1021/jm00207a022
Escherichia coli Escherichia coli FC 2400.0 None 10.1128/aac.00043-09
Escherichia coli Escherichia coli FC 10000.0 None 10.1128/aac.00043-09
Escherichia coli Escherichia coli MIC 0.39 ug.mL-1 10.1016/j.ejmech.2012.03.008
Escherichia coli Escherichia coli MIC 0.5 ug.mL-1 10.1128/aac.00400-09
Escherichia coli Escherichia coli MIC 0.8 ug.mL-1 10.1021/jm00207a022
Escherichia coli Escherichia coli MIC 0.8 ug.mL-1 10.1021/jm00211a006
Escherichia coli Escherichia coli MIC 0.8 ug.mL-1 10.1021/jm00228a003
Escherichia coli Escherichia coli MIC 1.0 ug.mL-1 10.1128/aac.00227-08
Escherichia coli Escherichia coli MIC 1.0 ug.mL-1 10.1128/aac.01028-07
Escherichia coli Escherichia coli MIC 1.0 ug.mL-1 10.1128/aac.01462-06
Escherichia coli Escherichia coli MIC 2.0 ug.mL-1 10.1016/j.ejmech.2020.112141
Escherichia coli Escherichia coli MIC 2.0 ug.mL-1 10.1128/aac.01011-08
Escherichia coli Escherichia coli MIC 4.0 ug.mL-1 10.1128/aac.00043-09
Escherichia coli Escherichia coli MIC 4.0 ug.mL-1 10.1128/aac.00158-08
Escherichia coli Escherichia coli MIC 4.0 ug.mL-1 10.1128/aac.00393-08
Escherichia coli Escherichia coli MIC 4.0 ug.mL-1 10.1128/aac.01028-07
Escherichia coli Escherichia coli MIC 8.0 ug.mL-1 10.1128/aac.00393-08
Escherichia coli Escherichia coli MIC 16.0 ug.mL-1 10.1128/aac.00227-08
Escherichia coli Escherichia coli MIC 16.0 ug.mL-1 10.1128/aac.00896-08
Escherichia coli Escherichia coli MIC 32.0 ug.mL-1 10.1021/acs.jmedchem.6b01742
Escherichia coli Escherichia coli MIC 32.0 ug.mL-1 10.1021/acsmedchemlett.7b00428
Escherichia coli Escherichia coli MIC 32.0 ug.mL-1 10.1128/aac.01011-08
Escherichia coli Escherichia coli MIC 32.0 ug.mL-1 10.1128/aac.01028-07
Escherichia coli Escherichia coli MIC 64.0 ug.mL-1 10.1021/acsmedchemlett.5b00098
Escherichia coli Escherichia coli MIC 64.0 ug.mL-1 10.1128/aac.00158-08
Escherichia coli Escherichia coli MIC 256.0 ug.mL-1 10.1128/aac.01011-08
Escherichia coli Escherichia coli MIC 256.0 ug.mL-1 10.1128/aac.01462-06
Escherichia coli Escherichia coli MIC 2048.0 ug.mL-1 10.1021/acsmedchemlett.7b00428
Escherichia coli Escherichia coli MIC 4096.0 ug.mL-1 10.1016/j.bmc.2021.116128
Escherichia coli Escherichia coli MIC 16000.0 ug.mL-1 10.1016/j.bmc.2021.116128
Escherichia coli Escherichia coli MIC nan None 10.1128/aac.00393-08
Escherichia coli Escherichia coli MIC50 2.0 ug.mL-1 10.1128/aac.00400-09
Escherichia coli Escherichia coli MIC50 16.0 ug.mL-1 10.1128/aac.01412-06
Escherichia coli Escherichia coli MIC90 16.0 ug.mL-1 10.1128/aac.01412-06
Escherichia coli Escherichia coli MIC90 64.0 ug.mL-1 10.1128/aac.00400-09
Escherichia coli Escherichia coli PD50 6.0 mg kg-1 10.1021/jm00211a006
Escherichia coli Escherichia coli PD50 6.0 mg kg-1 10.1021/jm00228a003
Escherichia coli Escherichia coli Ratio 1.0 None 10.1016/j.ejmech.2012.03.008
Escherichia coli Escherichia coli Ratio 4.0 None 10.1128/aac.01011-08
Fusobacterium varium Fusobacterium varium Activity nan None 10.1021/jm00207a022
Giardia intestinalis Putative fructose-1,6-bisphosphate aldolase Potency 17740.7 nM None
Haemophilus influenzae Haemophilus influenzae Activity nan None 10.1021/jm00207a022
Haemophilus influenzae Haemophilus influenzae Activity nan None 10.1128/aac.01538-07
Homo sapiens Acetylcholinesterase AC50 300000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Adenosine A1 receptor AC50 300000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Adenosine A2a receptor AC50 300000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Adenosine A3 receptor AC50 300000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-1a adrenergic receptor AC50 300000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-2a adrenergic receptor AC50 300000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-2b adrenergic receptor AC50 300000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-2c adrenergic receptor AC50 300000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Beta-1 adrenergic receptor AC50 300000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Beta-2 adrenergic receptor AC50 300000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Bile salt export pump AC50 300000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Bradykinin B2 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Cannabinoid CB1 receptor AC50 300000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Cholecystokinin A receptor AC50 300000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Cholecystokinin B receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Chromobox protein homolog 1 Potency 79432.8 nM None
Homo sapiens Cyclooxygenase-2 AC50 74999.8 nM 10.1038/s41467-023-40064-9
Homo sapiens Delta opioid receptor AC50 300000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine D1 receptor AC50 300000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine D2 receptor AC50 300000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine D3 receptor AC50 300000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine transporter AC50 300000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Endothelin receptor ET-A AC50 300000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Epidermal growth factor receptor erbB1 AC50 300000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Equilibrative nucleoside transporter 1 AC50 300000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Estrogen receptor alpha AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Estrogen receptor alpha AC50 300000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Gamma-aminobutyric acid receptor subunit alpha-1/alpha-2/beta-2/gamma-2 AC50 2400000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Ghrelin receptor AC50 300000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Glucocorticoid receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Glucocorticoid receptor AC50 300000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens HeLa IC20 270.0 ug ml-1 10.1128/aac.00729-05
Homo sapiens HeLa IC20 400.0 ug ml-1 10.1128/aac.00729-05
Homo sapiens HeLa IC50 400.0 ug.mL-1 10.1128/aac.00729-05
Homo sapiens HERG AC50 300000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Histamine H1 receptor AC50 300000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Histamine H2 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Histamine H3 receptor AC50 300000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Histone deacetylase 6 Inhibition -9.9 % 10.6019/CHEMBL4808148
Homo sapiens Histone deacetylase 6 Inhibition -5.59 % 10.6019/CHEMBL4808148
Homo sapiens Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 Potency 2993.5 nM None
Homo sapiens Homo sapiens CL 0.001 mL.min-1.kg-1 10.1124/dmd.112.049312
Homo sapiens Homo sapiens CL 0.007 mL.min-1.kg-1 10.1124/dmd.112.049312
Homo sapiens Homo sapiens CL 0.1 mL.min-1.kg-1 10.1021/jm901371v
Homo sapiens Homo sapiens CL 0.89 mL.min-1.kg-1 10.1021/jm900403j
Homo sapiens Homo sapiens CL 0.89 mL.min-1.kg-1 10.1021/jm901371v
Homo sapiens Homo sapiens CL_renal 0.78 mL.min-1.kg-1 10.1021/jm900403j
Homo sapiens Homo sapiens CL_renal 0.8 mL.min-1.kg-1 10.1021/jm901371v
Homo sapiens Homo sapiens DILI_Concern nan None 10.1016/j.drudis.2016.02.015
Homo sapiens Homo sapiens DILI_severity_class 3.0 None 10.1016/j.drudis.2016.02.015
Homo sapiens Homo sapiens F 90.0 % 10.1016/j.bmc.2007.08.060
Homo sapiens Homo sapiens Fa 1.0 None 10.1021/jm901371v
Homo sapiens Homo sapiens F_fraction 0.9 None 10.1021/jm901371v
Homo sapiens Homo sapiens Fg 0.9 None 10.1021/jm901371v
Homo sapiens Homo sapiens Fh 1.0 None 10.1021/jm901371v
Homo sapiens Homo sapiens Vdss 0.1 L.kg-1 10.1016/j.ejmech.2009.06.004
Homo sapiens Homo sapiens Vdss 0.12 L.kg-1 10.1021/jm901371v
Homo sapiens IL15-IL15 receptor Inhibition nan % 10.1016/j.ejmech.2017.05.034
Homo sapiens Kappa opioid receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Lysine-specific demethylase 4A Potency 79432.8 nM None
Homo sapiens Melanocortin receptor 3 AC50 300000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens MG-63 IC20 230.0 ug ml-1 10.1128/aac.00729-05
Homo sapiens MG-63 IC20 400.0 ug ml-1 10.1128/aac.00729-05
Homo sapiens MG-63 IC50 400.0 ug.mL-1 10.1128/aac.00729-05
Homo sapiens Monoamine oxidase A AC50 300000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Monoamine oxidase A Activity nan None 10.1021/jm800656v
Homo sapiens Mothers against decapentaplegic homolog 3 Potency 3981.1 nM None
Homo sapiens Motilin receptor AC50 300000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Multidrug resistance-associated protein 4 Km 81000.0 nM 10.1124/dmd.111.041731
Homo sapiens Mu opioid receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Mu opioid receptor AC50 300000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Muscarinic acetylcholine receptor M1 AC50 300000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Muscarinic acetylcholine receptor M2 AC50 300000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Muscarinic acetylcholine receptor M3 AC50 300000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Neuronal acetylcholine receptor protein alpha-4 subunit AC50 300000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Neuropeptide Y receptor type 1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Norepinephrine transporter AC50 300000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Oligopeptide transporter small intestine isoform Ki 30000000.0 nM 10.1021/jm048982w
Homo sapiens PBMC Activity nan None 10.1016/j.ejmech.2017.05.034
Homo sapiens Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Potency 39810.7 nM None
Homo sapiens Peroxisome proliferator-activated receptor gamma AC50 300000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Phosphodiesterase 3A AC50 300000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Phosphodiesterase 4D AC50 300000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Pregnane X receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Pregnane X receptor AC50 300000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Prelamin-A/C Potency 891.3 nM None
Homo sapiens Progesterone receptor AC50 300000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Receptor protein-tyrosine kinase erbB-2 AC50 300000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Regulator of G-protein signaling 4 Potency 26679.5 nM None
Homo sapiens Serotonin 1a (5-HT1a) receptor AC50 300000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2a (5-HT2a) receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2a (5-HT2a) receptor AC50 300000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2b (5-HT2b) receptor AC50 300000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2c (5-HT2c) receptor AC50 300000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 3a (5-HT3a) receptor AC50 300000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin transporter AC50 300000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serum Drug uptake 17.0 ug ml-1 10.1128/aac.00317-09
Homo sapiens Serum Drug uptake 57.0 mg/L 10.1128/aac.00389-08
Homo sapiens Serum Drug uptake 63.0 mg/L 10.1128/aac.00389-08
Homo sapiens Solute carrier family 22 member 11 Ki 1740.0 nM 10.1016/s0014-2999(02)01306-7
Homo sapiens Solute carrier family 22 member 6 Ki 180.0 nM 10.1016/s0014-2999(02)01306-7
Homo sapiens Solute carrier family 22 member 8 Ki 550.0 nM 10.1016/s0014-2999(02)01306-7
Homo sapiens Thromboxane A2 receptor AC50 300000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Type-1 angiotensin II receptor AC50 300000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Vascular endothelial growth factor receptor 2 AC50 300000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Vasopressin V1a receptor AC50 300000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Vasopressin V2 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Vitamin D receptor Potency 35481.3 nM None
Homo sapiens Vitamin D receptor Potency 79432.8 nM None
Homo sapiens Vitamin D receptor Potency 100000.0 nM None
Klebsiella aerogenes Klebsiella aerogenes MIC 1.6 ug.mL-1 10.1021/jm00211a006
Klebsiella aerogenes Klebsiella aerogenes MIC 1.6 ug.mL-1 10.1021/jm00228a003
Klebsiella aerogenes Klebsiella aerogenes MIC 50.0 ug.mL-1 10.1021/jm00207a022
Klebsiella aerogenes Klebsiella aerogenes MIC 64.0 ug.mL-1 10.1128/aac.01028-07
Klebsiella oxytoca Klebsiella oxytoca Activity 17.0 % 10.1128/aac.00400-09
Klebsiella oxytoca Klebsiella oxytoca Activity 23.0 % 10.1128/aac.00400-09
Klebsiella oxytoca Klebsiella oxytoca Activity 60.0 % 10.1128/aac.00400-09
Klebsiella oxytoca Klebsiella oxytoca MIC 0.5 ug.mL-1 10.1128/aac.00400-09
Klebsiella oxytoca Klebsiella oxytoca MIC50 8.0 ug.mL-1 10.1128/aac.00400-09
Klebsiella oxytoca Klebsiella oxytoca MIC90 32.0 ug.mL-1 10.1128/aac.00400-09
Klebsiella pneumoniae Klebsiella pneumoniae Activity 0.0 % 10.1128/aac.00852-08
Klebsiella pneumoniae Klebsiella pneumoniae Activity 1.8 % 10.1128/aac.00400-09
Klebsiella pneumoniae Klebsiella pneumoniae Activity 6.8 % 10.1128/aac.00400-09
Klebsiella pneumoniae Klebsiella pneumoniae Activity 91.4 % 10.1128/aac.00400-09
Klebsiella pneumoniae Klebsiella pneumoniae Activity 235.0 % 10.1128/aac.00852-08
Klebsiella pneumoniae Klebsiella pneumoniae Activity nan None 10.1128/aac.01538-07
Klebsiella pneumoniae Klebsiella pneumoniae ED50 42.0 mg.kg-1 10.1021/jm00207a022
Klebsiella pneumoniae Klebsiella pneumoniae MIC 0.5 ug.mL-1 10.1128/aac.00400-09
Klebsiella pneumoniae Klebsiella pneumoniae MIC 0.8 ug.mL-1 10.1021/jm00211a006
Klebsiella pneumoniae Klebsiella pneumoniae MIC 0.8 ug.mL-1 10.1021/jm00228a003
Klebsiella pneumoniae Klebsiella pneumoniae MIC 1.6 ug.mL-1 10.1021/jm00207a022
Klebsiella pneumoniae Klebsiella pneumoniae MIC 64.0 ug.mL-1 10.1128/aac.00158-08
Klebsiella pneumoniae Klebsiella pneumoniae MIC 4096.0 ug.mL-1 10.1016/j.bmc.2021.116128
Klebsiella pneumoniae Klebsiella pneumoniae MIC50 2.0 ug.mL-1 10.1128/aac.00400-09
Klebsiella pneumoniae Klebsiella pneumoniae MIC50 32.0 ug.mL-1 10.1128/aac.00852-08
Klebsiella pneumoniae Klebsiella pneumoniae MIC90 8.0 ug.mL-1 10.1128/aac.00400-09
Klebsiella pneumoniae Klebsiella pneumoniae MIC90 32.0 ug.mL-1 10.1128/aac.00852-08
Mus musculus Plasma fAUC 9416.67 ng.hr.mL-1 10.1128/aac.00642-09
Mus musculus Plasma fCmax 19.0 ug ml-1 10.1128/aac.00642-09
Mus musculus Plasma PPB 81.0 % 10.1128/aac.00642-09
Mus musculus Plasma T1/2 0.2333 hr 10.1128/aac.00642-09
Mus musculus Plasma Tmax 0.125 hr 10.1128/aac.00642-09
Neisseria gonorrhoeae Neisseria gonorrhoeae Activity nan None 10.1021/jm00207a022
Photinus pyralis Luciferin 4-monooxygenase Potency 40533.4 nM None
Prescottella equi Prescottella equi MIC 0.063 ug.mL-1 10.1016/j.ejmech.2019.111744
Proteus mirabilis Proteus mirabilis Activity 5.0 % 10.1128/aac.00400-09
Proteus mirabilis Proteus mirabilis Activity 8.4 % 10.1128/aac.00400-09
Proteus mirabilis Proteus mirabilis Activity 86.6 % 10.1128/aac.00400-09
Proteus mirabilis Proteus mirabilis ED50 79.0 mg.kg-1 10.1021/jm00207a022
Proteus mirabilis Proteus mirabilis MIC 0.063 ug.mL-1 10.1016/j.ejmech.2019.111744
Proteus mirabilis Proteus mirabilis MIC 1.0 ug.mL-1 10.1128/aac.00400-09
Proteus mirabilis Proteus mirabilis MIC 6.2 ug.mL-1 10.1021/jm00207a022
Proteus mirabilis Proteus mirabilis MIC50 8.0 ug.mL-1 10.1128/aac.00400-09
Proteus mirabilis Proteus mirabilis MIC90 16.0 ug.mL-1 10.1128/aac.00400-09
Proteus vulgaris Proteus vulgaris MIC 0.063 ug.mL-1 10.1016/j.ejmech.2019.111744
Proteus vulgaris Proteus vulgaris MIC 100.0 ug.mL-1 10.1021/jm00207a022
Providencia stuartii Providencia stuartii MIC 50.0 ug.mL-1 10.1021/jm00207a022
Pseudomonas aeruginosa Pseudomonas aeruginosa Activity 4.9 % 10.1128/aac.01538-07
Pseudomonas aeruginosa Pseudomonas aeruginosa Activity 6.2 % 10.1128/aac.01538-07
Pseudomonas aeruginosa Pseudomonas aeruginosa Activity 7.7 % 10.1128/aac.01538-07
Pseudomonas aeruginosa Pseudomonas aeruginosa Activity 7.8 % 10.1128/aac.01538-07
Pseudomonas aeruginosa Pseudomonas aeruginosa Activity nan None 10.1021/jm00211a006
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 16.0 ug.mL-1 10.1128/aac.00400-09
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 16.0 ug.mL-1 10.1128/aac.01011-08
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 100.0 ug.mL-1 10.1021/jm00207a022
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 16000.0 ug.mL-1 10.1016/j.bmc.2021.116128
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC nan None 10.1128/aac.00642-09
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC50 128.0 ug.mL-1 10.1128/aac.00400-09
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC90 128.0 ug.mL-1 10.1128/aac.00400-09
Rattus norvegicus Androgen Receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Rattus norvegicus Androgen Receptor AC50 300000.0 nM 10.1038/s41467-023-40064-9
Rattus norvegicus Cyclooxygenase-1 AC50 160000.0 nM 10.1038/s41467-023-40064-9
Rattus norvegicus GABA receptor alpha-1 subunit AC50 300000.0 nM 10.1038/s41467-023-40064-9
Rattus norvegicus Glutamate (NMDA) receptor subunit zeta 1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Rattus norvegicus Plasma Fu 0.18 None 10.1021/jm901371v
Rattus norvegicus Plasma logFu 0.11 None 10.1016/j.ejmech.2009.06.004
Rattus norvegicus Rattus norvegicus CL 1.4 mL.min-1.kg-1 10.1124/dmd.112.049312
Rattus norvegicus Rattus norvegicus CL 11.24 mL.min-1.kg-1 10.1124/dmd.112.049312
Rattus norvegicus Solute carrier family 22 member 6 Activity nan None 10.2133/dmpk.17.125
Rattus norvegicus Solute carrier family 22 member 6 Ki 450000.0 nM None
Rattus norvegicus Solute carrier family 22 member 6 Ki 560000.0 nM 10.1016/s0024-3205(02)01500-x
Rattus norvegicus Solute carrier family 22 member 8 Activity 13.6 % 10.1046/j.1471-4159.2002.01108.x
Rattus norvegicus Solute carrier family 22 member 8 Ki 780000.0 nM 10.1016/s0024-3205(02)01500-x
Rattus norvegicus Thioredoxin reductase 1, cytoplasmic Potency 11917.3 nM None
Rattus norvegicus Thioredoxin reductase 1, cytoplasmic Potency 50118.7 nM None
Salmonella Salmonella ED50 2.2 mg.kg-1 10.1021/jm00207a022
Salmonella Salmonella MIC 1.6 ug.mL-1 10.1021/jm00207a022
Salmonella Salmonella MIC 100.0 ug.mL-1 10.1021/jm00207a022
Salmonella enterica subsp. enterica serovar Paratyphi A Salmonella paratyphi MIC 0.8 ug.mL-1 10.1021/jm00211a006
Salmonella enterica subsp. enterica serovar Paratyphi A Salmonella paratyphi MIC 0.8 ug.mL-1 10.1021/jm00228a003
Salmonella enterica subsp. enterica serovar Typhimurium Salmonella typhimurium MIC 0.063 ug.mL-1 10.1016/j.ejmech.2019.111744
Salmonella enterica subsp. enterica serovar Typhimurium Salmonella typhimurium Ratio 1.0 None 10.1016/j.ejmech.2012.03.008
Serratia marcescens Serratia marcescens Activity 0.0 % 10.1128/aac.00400-09
Serratia marcescens Serratia marcescens Activity 0.9 % 10.1128/aac.00400-09
Serratia marcescens Serratia marcescens Activity 99.1 % 10.1128/aac.00400-09
Serratia marcescens Serratia marcescens MIC 2.0 ug.mL-1 10.1128/aac.00400-09
Serratia marcescens Serratia marcescens MIC 64.0 ug.mL-1 10.1128/aac.01028-07
Serratia marcescens Serratia marcescens MIC50 128.0 ug.mL-1 10.1128/aac.00400-09
Serratia marcescens Serratia marcescens MIC90 128.0 ug.mL-1 10.1128/aac.00400-09
Severe acute respiratory syndrome coronavirus 2 Replicase polyprotein 1ab Inhibition -4.6 % 10.6019/CHEMBL4495564
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 IC50 19952.62 nM 10.6019/CHEMBL4651402
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 IC50 20000.0 nM 10.6019/CHEMBL4651402
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Inhibition 0.04 % 10.6019/CHEMBL4495565
Shigella flexneri Shigella flexneri MIC 0.4 ug.mL-1 10.1021/jm00211a006
Shigella flexneri Shigella flexneri MIC 0.4 ug.mL-1 10.1021/jm00228a003
Shigella sonnei Shigella sonnei MIC 16.0 ug.mL-1 10.1128/aac.00227-08
Staphylococcus Staphylococcus MIC90 1.0 ug.mL-1 10.1128/aac.00389-08
Staphylococcus aureus Staphylococcus aureus Activity 0.0 % 10.1128/aac.00317-09
Staphylococcus aureus Staphylococcus aureus Activity 0.0 % 10.1128/aac.00400-09
Staphylococcus aureus Staphylococcus aureus Activity 0.0 % 10.1128/aac.01244-06
Staphylococcus aureus Staphylococcus aureus Activity 0.0 % 10.1128/aac.01538-07
Staphylococcus aureus Staphylococcus aureus Activity 1.0 % 10.1128/aac.00317-09
Staphylococcus aureus Staphylococcus aureus Activity 2.0 % 10.1128/aac.00317-09
Staphylococcus aureus Staphylococcus aureus Activity 3.0 % 10.1128/aac.00317-09
Staphylococcus aureus Staphylococcus aureus Activity 5.0 % 10.1128/aac.00317-09
Staphylococcus aureus Staphylococcus aureus Activity 5.0 % 10.1128/aac.00629-07
Staphylococcus aureus Staphylococcus aureus Activity 6.0 % 10.1128/aac.00317-09
Staphylococcus aureus Staphylococcus aureus Activity 8.0 % 10.1128/aac.00317-09
Staphylococcus aureus Staphylococcus aureus Activity 9.0 % 10.1128/aac.00317-09
Staphylococcus aureus Staphylococcus aureus Activity 12.0 % 10.1128/aac.00317-09
Staphylococcus aureus Staphylococcus aureus Activity 20.0 % 10.1128/aac.00317-09
Staphylococcus aureus Staphylococcus aureus Activity 23.0 % 10.1128/aac.00317-09
Staphylococcus aureus Staphylococcus aureus Activity 24.0 % 10.1128/aac.00317-09
Staphylococcus aureus Staphylococcus aureus Activity 33.0 % 10.1128/aac.00317-09
Staphylococcus aureus Staphylococcus aureus Activity 50.0 % 10.1128/aac.00317-09
Staphylococcus aureus Staphylococcus aureus Activity 89.0 % 10.1128/aac.00317-09
Staphylococcus aureus Staphylococcus aureus Activity 100.0 % 10.1128/aac.00317-09
Staphylococcus aureus Staphylococcus aureus Activity 100.0 % 10.1128/aac.00400-09
Staphylococcus aureus Staphylococcus aureus Activity 100.0 % 10.1128/aac.01244-06
Staphylococcus aureus Staphylococcus aureus Activity 100.0 % 10.1128/aac.01538-07
Staphylococcus aureus Staphylococcus aureus Activity 781.0 mm3 10.1128/aac.00642-09
Staphylococcus aureus Staphylococcus aureus Activity 877.0 mm3 10.1128/aac.00642-09
Staphylococcus aureus Staphylococcus aureus Activity 912.0 mm3 10.1128/aac.00642-09
Staphylococcus aureus Staphylococcus aureus Activity 987.0 mm3 10.1128/aac.00642-09
Staphylococcus aureus Staphylococcus aureus Activity 1070.0 mm3 10.1128/aac.00642-09
Staphylococcus aureus Staphylococcus aureus Activity 1090.0 mm3 10.1128/aac.00642-09
Staphylococcus aureus Staphylococcus aureus Activity 1300.0 mm3 10.1128/aac.00642-09
Staphylococcus aureus Staphylococcus aureus Activity 1383.0 mm3 10.1128/aac.00642-09
Staphylococcus aureus Staphylococcus aureus Activity nan None 10.1016/j.bmc.2019.115095
Staphylococcus aureus Staphylococcus aureus Activity nan None 10.1021/jm00228a003
Staphylococcus aureus Staphylococcus aureus Activity nan None 10.1021/jm0703183
Staphylococcus aureus Staphylococcus aureus deltalog10CFU -2.0 None 10.1128/aac.00642-09
Staphylococcus aureus Staphylococcus aureus deltalog10CFU -1.7 None 10.1128/aac.00642-09
Staphylococcus aureus Staphylococcus aureus deltalog10CFU -1.3 None 10.1128/aac.00642-09
Staphylococcus aureus Staphylococcus aureus deltalog10CFU -1.2 None 10.1128/aac.00642-09
Staphylococcus aureus Staphylococcus aureus deltalog10CFU -0.6 None 10.1128/aac.00642-09
Staphylococcus aureus Staphylococcus aureus deltalog10CFU -0.3 None 10.1128/aac.00642-09
Staphylococcus aureus Staphylococcus aureus deltalog10CFU 0.6 None 10.1128/aac.00642-09
Staphylococcus aureus Staphylococcus aureus deltalog10CFU 1.6 None 10.1128/aac.00642-09
Staphylococcus aureus Staphylococcus aureus ED50 22.0 mg.kg-1 10.1021/jm00207a022
Staphylococcus aureus Staphylococcus aureus IZ 2.0 mm 10.1016/j.bmcl.2007.05.065
Staphylococcus aureus Staphylococcus aureus IZ 14.0 mm 10.1128/aac.00629-07
Staphylococcus aureus Staphylococcus aureus IZ 18.0 mm 10.1128/aac.00629-07
Staphylococcus aureus Staphylococcus aureus IZ 30.0 mm 10.1016/j.bmcl.2007.05.065
Staphylococcus aureus Staphylococcus aureus MBC nan None 10.1007/s00044-013-0844-5
Staphylococcus aureus Staphylococcus aureus MIC 0.2 ug.mL-1 10.1021/jm00207a022
Staphylococcus aureus Staphylococcus aureus MIC 0.4 ug.mL-1 10.1021/jm00207a022
Staphylococcus aureus Staphylococcus aureus MIC 0.4 ug.mL-1 10.1021/jm00211a006
Staphylococcus aureus Staphylococcus aureus MIC 0.4 ug.mL-1 10.1021/jm00228a003
Staphylococcus aureus Staphylococcus aureus MIC 0.5 ug.mL-1 10.1128/aac.00317-09
Staphylococcus aureus Staphylococcus aureus MIC 0.5 ug.mL-1 10.1128/aac.00400-09
Staphylococcus aureus Staphylococcus aureus MIC 0.5 ug.mL-1 10.1128/aac.00435-07
Staphylococcus aureus Staphylococcus aureus MIC 0.5 ug.mL-1 10.1128/aac.00594-10
Staphylococcus aureus Staphylococcus aureus MIC 0.5 ug.mL-1 10.1128/aac.00642-09
Staphylococcus aureus Staphylococcus aureus MIC 0.6 ug.mL-1 10.1128/aac.00317-09
Staphylococcus aureus Staphylococcus aureus MIC 0.9 ug.mL-1 10.1128/aac.00317-09
Staphylococcus aureus Staphylococcus aureus MIC 1.0 ug.mL-1 10.1128/aac.00317-09
Staphylococcus aureus Staphylococcus aureus MIC 2.0 ug.mL-1 10.1016/j.ejmech.2020.112141
Staphylococcus aureus Staphylococcus aureus MIC 2.8 ug.mL-1 10.1128/aac.00317-09
Staphylococcus aureus Staphylococcus aureus MIC 12.5 ug.mL-1 10.1128/aac.00395-07
Staphylococcus aureus Staphylococcus aureus MIC 16.0 ug.mL-1 10.1128/aac.00317-09
Staphylococcus aureus Staphylococcus aureus MIC 16.0 ug.mL-1 10.1128/aac.00435-07
Staphylococcus aureus Staphylococcus aureus MIC 16.0 ug.mL-1 10.1128/aac.00642-09
Staphylococcus aureus Staphylococcus aureus MIC 32.0 ug.mL-1 10.1128/aac.00317-09
Staphylococcus aureus Staphylococcus aureus MIC 32.0 ug.mL-1 10.1128/aac.00400-09
Staphylococcus aureus Staphylococcus aureus MIC 100.0 ug.mL-1 10.1128/aac.00395-07
Staphylococcus aureus Staphylococcus aureus MIC 128.0 ug.mL-1 10.1007/s00044-013-0844-5
Staphylococcus aureus Staphylococcus aureus MIC 200.0 ug.mL-1 10.1128/aac.00395-07
Staphylococcus aureus Staphylococcus aureus MIC 256.0 ug.mL-1 10.1021/acs.jnatprod.7b00133
Staphylococcus aureus Staphylococcus aureus MIC 256.0 ug.mL-1 10.1128/aac.00594-10
Staphylococcus aureus Staphylococcus aureus MIC 400.0 ug.mL-1 10.1128/aac.00395-07
Staphylococcus aureus Staphylococcus aureus MIC 4096.0 ug.mL-1 10.1016/j.bmc.2021.116128
Staphylococcus aureus Staphylococcus aureus MIC 17600.0 nM 10.1016/j.ejmech.2014.09.096
Staphylococcus aureus Staphylococcus aureus MIC50 0.5 ug.mL-1 10.1128/aac.00400-09
Staphylococcus aureus Staphylococcus aureus MIC50 1.0 ug.mL-1 10.1128/aac.00317-09
Staphylococcus aureus Staphylococcus aureus MIC50 2.0 ug.mL-1 10.1128/aac.00317-09
Staphylococcus aureus Staphylococcus aureus MIC50 4.0 ug.mL-1 10.1128/aac.00317-09
Staphylococcus aureus Staphylococcus aureus MIC50 8.0 ug.mL-1 10.1128/aac.00317-09
Staphylococcus aureus Staphylococcus aureus MIC50 64.0 ug.mL-1 10.1128/aac.00400-09
Staphylococcus aureus Staphylococcus aureus MIC90 1.0 ug.mL-1 10.1128/aac.00317-09
Staphylococcus aureus Staphylococcus aureus MIC90 1.0 ug.mL-1 10.1128/aac.00400-09
Staphylococcus aureus Staphylococcus aureus MIC90 4.0 ug.mL-1 10.1128/aac.00317-09
Staphylococcus aureus Staphylococcus aureus MIC90 8.0 ug.mL-1 10.1128/aac.00317-09
Staphylococcus aureus Staphylococcus aureus MIC90 16.0 ug.mL-1 10.1128/aac.00317-09
Staphylococcus aureus Staphylococcus aureus MIC90 64.0 ug.mL-1 10.1128/aac.00317-09
Staphylococcus aureus Staphylococcus aureus MIC90 128.0 ug.mL-1 10.1128/aac.00400-09
Staphylococcus epidermidis Staphylococcus epidermidis Activity 0.0 % 10.1128/aac.00400-09
Staphylococcus epidermidis Staphylococcus epidermidis Activity 0.0 % 10.1128/aac.01538-07
Staphylococcus epidermidis Staphylococcus epidermidis Activity 100.0 % 10.1128/aac.00400-09
Staphylococcus epidermidis Staphylococcus epidermidis Activity 100.0 % 10.1128/aac.01538-07
Staphylococcus epidermidis Staphylococcus epidermidis MIC 0.5 ug.mL-1 10.1128/aac.00400-09
Staphylococcus epidermidis Staphylococcus epidermidis MIC 0.8 ug.mL-1 10.1021/jm00207a022
Staphylococcus epidermidis Staphylococcus epidermidis MIC 32.0 ug.mL-1 10.1021/acs.jmedchem.6b00867
Staphylococcus epidermidis Staphylococcus epidermidis MIC 32.0 ug.mL-1 10.1021/acs.jmedchem.6b01742
Staphylococcus epidermidis Staphylococcus epidermidis MIC 32.0 ug.mL-1 10.1128/aac.00400-09
Staphylococcus epidermidis Staphylococcus epidermidis MIC 17600.0 nM 10.1016/j.ejmech.2014.09.096
Staphylococcus epidermidis Staphylococcus epidermidis MIC50 1.0 ug.mL-1 10.1128/aac.00400-09
Staphylococcus epidermidis Staphylococcus epidermidis MIC50 64.0 ug.mL-1 10.1128/aac.00400-09
Staphylococcus epidermidis Staphylococcus epidermidis MIC90 4.0 ug.mL-1 10.1128/aac.00400-09
Staphylococcus epidermidis Staphylococcus epidermidis MIC90 128.0 ug.mL-1 10.1128/aac.00400-09
Staphylococcus lugdunensis Staphylococcus lugdunensis Activity 7.0 % 10.1128/aac.01052-06
Staphylococcus lugdunensis Staphylococcus lugdunensis Activity 13.0 % 10.1128/aac.01052-06
Staphylococcus lugdunensis Staphylococcus lugdunensis Activity 80.0 % 10.1128/aac.01052-06
Staphylococcus lugdunensis Staphylococcus lugdunensis BBC 1.0 ug ml-1 10.1128/aac.01052-06
Staphylococcus lugdunensis Staphylococcus lugdunensis BBC 2.0 ug ml-1 10.1128/aac.01052-06
Staphylococcus lugdunensis Staphylococcus lugdunensis BBC 4.0 ug ml-1 10.1128/aac.01052-06
Staphylococcus lugdunensis Staphylococcus lugdunensis BBC 8.0 ug ml-1 10.1128/aac.01052-06
Staphylococcus lugdunensis Staphylococcus lugdunensis BBC 128.0 ug ml-1 10.1128/aac.01052-06
Staphylococcus lugdunensis Staphylococcus lugdunensis MBC50 0.5 ug ml-1 10.1128/aac.01052-06
Staphylococcus lugdunensis Staphylococcus lugdunensis MBC90 1.0 ug ml-1 10.1128/aac.01052-06
Staphylococcus lugdunensis Staphylococcus lugdunensis MIC50 0.25 ug.mL-1 10.1128/aac.01052-06
Staphylococcus lugdunensis Staphylococcus lugdunensis MIC90 0.5 ug.mL-1 10.1128/aac.01052-06
Staphylococcus saprophyticus Staphylococcus saprophyticus MIC 1.0 ug.mL-1 10.1128/aac.01150-07
Staphylococcus saprophyticus Staphylococcus saprophyticus MIC 4.0 ug.mL-1 10.1128/aac.01150-07
Staphylococcus saprophyticus Staphylococcus saprophyticus MIC 16.0 ug.mL-1 10.1128/aac.01150-07
Staphylococcus saprophyticus Staphylococcus saprophyticus MIC 32.0 ug.mL-1 10.1128/aac.01150-07
Staphylococcus saprophyticus Staphylococcus saprophyticus MIC 64.0 ug.mL-1 10.1128/aac.01150-07
Staphylococcus saprophyticus Staphylococcus saprophyticus MIC 128.0 ug.mL-1 10.1128/aac.01150-07
Staphylococcus saprophyticus Staphylococcus saprophyticus MIC50 1.0 ug.mL-1 10.1128/aac.01150-07
Staphylococcus saprophyticus Staphylococcus saprophyticus MIC90 2.0 ug.mL-1 10.1128/aac.01150-07
Stenotrophomonas maltophilia Stenotrophomonas maltophilia MIC 128.0 ug.mL-1 10.1128/aac.00400-09
Stenotrophomonas maltophilia Stenotrophomonas maltophilia MIC50 128.0 ug.mL-1 10.1128/aac.00400-09
Stenotrophomonas maltophilia Stenotrophomonas maltophilia MIC90 128.0 ug.mL-1 10.1128/aac.00400-09
Streptococcus Streptococcus MIC90 0.1 ug.mL-1 10.1128/aac.00389-08
Streptococcus agalactiae Streptococcus agalactiae MIC 0.063 ug.mL-1 10.1128/aac.01716-08
Streptococcus agalactiae Streptococcus agalactiae MIC 0.12 ug.mL-1 10.1128/aac.00185-08
Streptococcus agalactiae Streptococcus agalactiae MIC 0.5 ug.mL-1 10.1128/aac.00185-08
Streptococcus agalactiae Streptococcus agalactiae MIC 1.0 ug.mL-1 10.1128/aac.00185-08
Streptococcus agalactiae Streptococcus agalactiae MIC 2.0 ug.mL-1 10.1128/aac.00185-08
Streptococcus agalactiae Streptococcus agalactiae MIC50 0.125 ug.mL-1 10.1128/aac.01716-08
Streptococcus agalactiae Streptococcus agalactiae MIC90 0.25 ug.mL-1 10.1128/aac.01716-08
Streptococcus pneumoniae Streptococcus pneumoniae Activity nan None 10.1128/aac.01538-07
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.063 ug.mL-1 10.1016/j.ejmech.2019.111744
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.1 ug.mL-1 10.1021/jm00207a022
Streptococcus pneumoniae Streptococcus pneumoniae MIC 1.0 ug.mL-1 10.1128/aac.00185-08
Streptococcus pyogenes Streptococcus pyogenes ED50 1.8 mg.kg-1 10.1021/jm00207a022
Streptococcus pyogenes Streptococcus pyogenes MIC 0.1 ug.mL-1 10.1021/jm00207a022
Streptococcus sp. 'group B' Streptococcus sp. 'group B' MIC 0.12 ug.mL-1 10.1128/aac.00461-08
Streptococcus sp. 'group B' Streptococcus sp. 'group B' MIC 0.25 ug.mL-1 10.1128/aac.00461-08
Streptococcus sp. 'group B' Streptococcus sp. 'group B' MIC 0.5 ug.mL-1 10.1128/aac.00461-08
Streptococcus sp. 'group B' Streptococcus sp. 'group B' MIC 1.0 ug.mL-1 10.1128/aac.00461-08
Streptococcus sp. 'group B' Streptococcus sp. 'group B' MIC 2.0 ug.mL-1 10.1128/aac.00461-08
Streptococcus sp. 'group B' Streptococcus sp. 'group B' MIC 16.0 ug.mL-1 10.1128/aac.00461-08
Trypanosoma brucei 6-phospho-1-fructokinase Potency 756.9 nM None
None ADMET CL 0.88 mL.min-1.kg-1 10.1002/jps.20373
None ADMET CL 0.89 mL.min-1.kg-1 10.1124/dmd.108.020479
None ADMET CL 1.9 mL.min-1.kg-1 10.1002/jps.20373
None ADMET CL 3.5 mL.min-1.kg-1 10.1002/jps.20373
None ADMET CL 6.7 mL.min-1.kg-1 10.1002/jps.20373
None ADMET Drug excretion 0.1 % 10.1124/dmd.112.049312
None ADMET Drug excretion 2.0 % 10.1124/dmd.112.049312
None ADMET Drug excretion 30.0 % 10.1124/dmd.112.049312
None ADMET Drug uptake 6.9 ug ml-1 10.1128/aac.00317-09
None ADMET Drug uptake 13.5 ug 10.1128/aac.00389-08
None ADMET k 0.107 hr-1 10.1021/jm00371a025
None ADMET k 0.217 hr-1 10.1021/jm00371a025
None ADMET logP(lung) -0.78 None 10.1016/j.ejmech.2007.04.002
None ADMET MRT 2.2 hr 10.1124/dmd.108.020479
None ADMET PPB 27.55 % 10.6019/CHEMBL3301361
None ADMET PPB 90.32 % 10.6019/CHEMBL3301361
None ADMET Ratio 0.25 None 10.1128/aac.00389-08
None ADMET T1/2 1.7 hr 10.1124/dmd.108.020479
None ADMET Vdss 0.11 L.kg-1 10.1002/jps.20373
None ADMET Vdss 0.12 L.kg-1 10.1124/dmd.108.020479
None ADMET Vdss 0.13 L.kg-1 10.1002/jps.20373
None ADMET Vdss 0.23 mL/min/kg 10.1002/jps.20373
None ADMET Vdss 0.27 L.kg-1 10.1002/jps.20373
None Hepatotoxicity Alkaline Phosphatase Increase - Activity Score nan None 10.2174/1570163043334794
None Hepatotoxicity Alkaline Phosphatase Increase - Index Value nan None 10.2174/1570163043334794
None Hepatotoxicity Alkaline Phosphatase Increase - Number of Reports nan None 10.2174/1570163043334794
None Hepatotoxicity Composite Activity - Active 0.0 None 10.2174/1570163043334794
None Hepatotoxicity Composite Activity - Marginal 0.0 None 10.2174/1570163043334794
None Hepatotoxicity Composite Activity - Score nan None 10.2174/1570163043334794
None Hepatotoxicity GGT Increase - Activity Score nan None 10.2174/1570163043334794
None Hepatotoxicity GGT Increase - Index Value nan None 10.2174/1570163043334794
None Hepatotoxicity GGT Increase - Number of Reports nan None 10.2174/1570163043334794
None Hepatotoxicity Hepatotoxicity nan None 10.1021/tx900326k
None Hepatotoxicity HepSE_bilirubinemia 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_cholecystitis 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_cholelithiasis 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_cirrhosis 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_Combined Scores 1.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_elevated liver function tests 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_hepatic failure 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_hepatic necrosis 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_hepatitis 1.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_hepatomegaly 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_jaundice 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_liver disease 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_liver fatty 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_liver function tests abnormal 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity LDH Increase - Activity Score nan None 10.2174/1570163043334794
None Hepatotoxicity LDH Increase - Index Value nan None 10.2174/1570163043334794
None Hepatotoxicity LDH Increase - Number of Reports nan None 10.2174/1570163043334794
None Hepatotoxicity SGOT Increase - Activity Score nan None 10.2174/1570163043334794
None Hepatotoxicity SGOT Increase - Index Value nan None 10.2174/1570163043334794
None Hepatotoxicity SGOT Increase - Number of Reports nan None 10.2174/1570163043334794
None Hepatotoxicity SGPT Increase - Activity Score nan None 10.2174/1570163043334794
None Hepatotoxicity SGPT Increase - Index Value nan None 10.2174/1570163043334794
None Hepatotoxicity SGPT Increase - Number of Reports nan None 10.2174/1570163043334794
None NON-PROTEIN TARGET fT>MIC 0.3 hr 10.1128/aac.00642-09
None NON-PROTEIN TARGET fT>MIC 0.8 hr 10.1128/aac.00642-09
None NON-PROTEIN TARGET fT>MIC 1.3 % 10.1128/aac.00642-09
None NON-PROTEIN TARGET fT>MIC 1.5 hr 10.1128/aac.00642-09
None NON-PROTEIN TARGET fT>MIC 2.4 hr 10.1128/aac.00642-09
None NON-PROTEIN TARGET fT>MIC 3.3 % 10.1128/aac.00642-09
None NON-PROTEIN TARGET fT>MIC 6.4 % 10.1128/aac.00642-09
None NON-PROTEIN TARGET fT>MIC 10.2 % 10.1128/aac.00642-09
None NON-PROTEIN TARGET Fu 0.18 None 10.1124/dmd.108.020479
None NON-PROTEIN TARGET Hepatotoxicity (acute) 0.0 % 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (animal toxicity known) nan None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (benign tumour) 0.0 None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (granulomatous hepatitis) 0.0 None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (mechanism) nan None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (moderate) 11.0 None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (moderate) 42.9 % 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (time to onset) nan None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET IC20 380.0 ug ml-1 10.1128/aac.00729-05
None NON-PROTEIN TARGET IC50 400.0 ug.mL-1 10.1128/aac.00729-05
None No relevant target pKa 2.1 None 10.1016/j.ejmech.2009.06.004
None Nucleic Acid Ratio 5.0 None 10.1128/aac.00389-08
None Nucleic Acid Ratio 60.75 None 10.1128/aac.00389-08
None Osteoblast IC20 400.0 ug ml-1 10.1128/aac.00729-05
None Osteoblast IC50 400.0 ug.mL-1 10.1128/aac.00729-05
None Unchecked Ac50 0.3548 uM None
None Unchecked Ac50 0.5623 uM None
None Unchecked Ac50 17.78 uM None
None Unchecked Ac50 22.39 uM None
None Unchecked AC50 354.8 nM None
None Unchecked AC50 570.0 nM None
None Unchecked AC50 17782.8 nM None
None Unchecked AC50 22387.2 nM None
None Unchecked Activity 2.1 % 10.1128/aac.00083-07
None Unchecked Hepatotoxicity (acute) 2.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (association with vascular disease) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (choleostasis) 1.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (chronic liver disease) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (cirrhosis) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (comment) nan None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (cytolytic) 1.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (malignant tumour) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (severe hepatitis) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (steatosis) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (successful reintroduction) nan None 10.1016/s0399-8320(04)95062-2
None Unchecked Kcat 0.25 /s 10.1128/aac.01252-09
None Unchecked Kcat 0.46 /s 10.1128/aac.00083-07
None Unchecked Kcat 0.55 /s 10.1128/aac.01252-09
None Unchecked Kcat 0.56 /s 10.1128/aac.01028-07
None Unchecked Kcat 2.2 /s 10.1128/aac.01028-07
None Unchecked Kcat 12.5 /s 10.1128/aac.01028-07
None Unchecked Kcat/Km 0.016 /uM/s 10.1128/aac.01028-07
None Unchecked Kcat/Km 0.018 /uM/s 10.1128/aac.00083-07
None Unchecked Kcat/Km 0.03 /uM/s 10.1128/aac.01028-07
None Unchecked Kcat/Km 0.032 /uM/s 10.1128/aac.01028-07
None Unchecked Kcat/Km 3.1 10'3/M/s 10.1128/aac.01252-09
None Unchecked Kcat/Km 4.6 10'3/M/s 10.1128/aac.01252-09
None Unchecked Km 25000.0 nM 10.1128/aac.00083-07
None Unchecked Km 35000.0 nM 10.1128/aac.01028-07
None Unchecked Km 68000.0 nM 10.1128/aac.01028-07
None Unchecked Km 80000.0 nM 10.1128/aac.01252-09
None Unchecked Km 120000.0 nM 10.1128/aac.01252-09
None Unchecked Km 417000.0 nM 10.1128/aac.01028-07
None Unchecked Potency 35481.3 nM None

Metabolism Information