Molecule

Virginiamycin Factor M1

AlkaPlorer ID: AK013545

Synonym: None

IUPAC Name: (10R,11R,12E,21S)-21-hydroxy-11,19-dimethyl-10-propan-2-yl-9,26-dioxa-3,15,28-triazatricyclo[23.2.1.03,7]octacosa-1(27),6,12,17,19,25(28)-hexaene-2,8,14,23-tetrone

Structure

SMILES: CC1=C\[C@@H](O)CC(=O)CC2=NC(=CO2)C(=O)N2CCC=C2C(=O)O[C@H](C(C)C)[C@H](C)/C=C/C(=O)NC\C=C\1

InChI: InChI=1S/C28H35N3O7/c1-17(2)26-19(4)9-10-24(34)29-11-5-7-18(3)13-20(32)14-21(33)15-25-30-22(16-37-25)27(35)31-12-6-8-23(31)28(36)38-26/h5,7-10,13,16-17,19-20,26,32H,6,11-12,14-15H2,1-4H3,(H,29,34)/b7-5+,10-9+,18-13+/t19-,20-,26-/m1/s1

InChIKey: DAIKHDNSXMZDCU-FQTGFAPKSA-N

Reference

A stepwise increase in pristinamycin II biosynthesis by Streptomyces pristinaespiralis through combinatorial metabolic engineering

PubChem CID: 5459319

CAS: 21411-53-0

LOTUS: LTS0129666

SuperNatural Ⅲ: SN0060449-07

NPASS: NPC58001

{

NPAtlas: NPA003740

Source

Species	Genus	Family	Order	Class	Phylum	Kingdom	Domain
Carex pendula	Carex	Cyperaceae	Poales	Magnoliopsida	Streptophyta	Viridiplantae	Eukaryota
Gueriniella serratulae	Gueriniella	Monophlebidae	Hemiptera	Insecta	Arthropoda	Metazoa	Eukaryota
Streptomyces pristinaespiralis	Streptomyces	Streptomycetaceae	Kitasatosporales	Actinomycetes	Actinomycetota	None	Bacteria
Hydrangea macrophylla	Hydrangea	Hydrangeaceae	Cornales	Magnoliopsida	Streptophyta	Viridiplantae	Eukaryota
Halobates hayanus	Halobates	Gerridae	Hemiptera	Insecta	Arthropoda	Metazoa	Eukaryota
None	Campylobacter	Campylobacteraceae	Campylobacterales	Epsilonproteobacteria	Campylobacterota	None	Bacteria
Nepeta tuberosa	Nepeta	Lamiaceae	Lamiales	Magnoliopsida	Streptophyta	Viridiplantae	Eukaryota

Properties Information

Molecule Weight: 525.6020000000003

TPSA？: 139.04000000000002

MolLogP？: 2.6594000000000007

Number of H-Donors: 2

Number of H-Acceptors: 8

RingCount: 3

Activities Information

Organism	Target Name	Standard Type	Standard Value	Standard Units	doi
Staphylococcus aureus	Staphylococcus aureus	MIC	1.0	ug.mL-1	10.1128/aac.01113-10
Staphylococcus aureus	Staphylococcus aureus	MIC	4.0	ug.mL-1	10.1128/aac.00570-09
Staphylococcus aureus	Staphylococcus aureus	MIC	4.0	ug.mL-1	10.1128/aac.01376-08
Staphylococcus aureus	Staphylococcus aureus	MIC	32.0	ug.mL-1	10.1128/aac.00570-09
Staphylococcus aureus	Staphylococcus aureus	MIC	32.0	ug.mL-1	10.1128/aac.01113-10
Staphylococcus aureus	Staphylococcus aureus	MIC	128.0	ug.mL-1	10.1128/aac.01376-08