Evolitrine
AlkaPlorer ID: AK013834
Synonym: None
IUPAC Name: 4,7-dimethoxyfuro[2,3-b]quinoline
Structure
SMILES: COC1=CC=C2C(OC)=C3C=COC3=NC2=C1
InChI: InChI=1S/C13H11NO3/c1-15-8-3-4-9-11(7-8)14-13-10(5-6-17-13)12(9)16-2/h3-7H,1-2H3
InChIKey: TWGHMXOYRUTQOL-UHFFFAOYSA-N
Reference
Two fungicidal phenylethanones from Euodia lunu-ankenda root bark
PubChem CID: 196980
CAS: 523-66-0
LOTUS: LTS0026527
SuperNatural Ⅲ: SN0361715
COCONUT: CNP0311823
Source
| Species | Genus | Family | Order | Class | Phylum | Kingdom | Domain |
|---|---|---|---|---|---|---|---|
| Boronia pinnata | Boronia | Rutaceae | Sapindales | Magnoliopsida | Streptophyta | Viridiplantae | Eukaryota |
Properties Information
Molecule Weight: 229.235
TPSA？: 44.49
MolLogP？: 2.998200000000001
Number of H-Donors: 0
Number of H-Acceptors: 4
RingCount: 3
Activities Information
| Organism | Target Name | Standard Type | Standard Value | Standard Units | doi |
|---|---|---|---|---|---|
| Homo sapiens | Hypoxia-inducible factor 1 alpha | Activity | nan | None | 10.1016/j.bmcl.2008.04.078 |
| Homo sapiens | Raji | Activity | 60.0 | % | 10.1021/np0000318 |
| Homo sapiens | Raji | Activity | 80.0 | % | 10.1021/np0000318 |
| Homo sapiens | Serine/threonine-protein kinase mTOR | Activity | nan | None | 10.1016/j.bmcl.2008.04.078 |
| Rattus norvegicus | Rattus norvegicus | Inhibition | 62.0 | % | 10.1016/j.ejmech.2021.113165 |
| None | Unchecked | Activity | 18.7 | % | 10.1021/np0000318 |
| None | Unchecked | Activity | 44.1 | % | 10.1021/np0000318 |
| None | Unchecked | Activity | 75.0 | % | 10.1021/np0000318 |
| None | Unchecked | Activity | 100.0 | % | 10.1021/np0000318 |
| None | Unchecked | Activity | nan | None | 10.1016/j.bmcl.2008.04.078 |