melanin
AlkaPlorer ID: AK013969
Synonym: 'Melanin'
IUPAC Name: 6,14-dimethyl-4,12-diazapentacyclo[8.6.1.12,5.013,17.09,18]octadeca-1(17),2,5,9(18),10,13-hexaene-7,8,15,16-tetrone
Structure
SMILES: CC1=C2NC=C3C4=C5C(=C(C)C(=O)C4=O)NC=C5C(=C23)C(=O)C1=O
InChI: InChI=1S/C18H10N2O4/c1-5-13-9-7(3-19-13)12-10-8(11(9)17(23)15(5)21)4-20-14(10)6(2)16(22)18(12)24/h3-4,19-20H,1-2H3
InChIKey: XUMBMVFBXHLACL-UHFFFAOYSA-N
Reference
Genome Sequence of the Streptomycin-Producing Microorganism<i>Streptomyces griseus</i>IFO 13350
PubChem CID: 6325610
CAS: 8049-97-6
LOTUS: LTS0103209
COCONUT: CNP0301754
Source
| Species | Genus | Family | Order | Class | Phylum | Kingdom | Domain |
|---|---|---|---|---|---|---|---|
| Streptomyces albidoflavus | Streptomyces | Streptomycetaceae | Kitasatosporales | Actinomycetes | Actinomycetota | None | Bacteria |
Properties Information
Molecule Weight: 318.28800000000007
TPSA？: 99.86
MolLogP？: 1.3266399999999996
Number of H-Donors: 2
Number of H-Acceptors: 4
RingCount: 5
Activities Information
| Organism | Target Name | Standard Type | Standard Value | Standard Units | doi |
|---|---|---|---|---|---|
| Homo sapiens | HepG2 | Activity | 100.0 | % | 10.1039/C6MD00646A |
| Mus musculus | Mus musculus | Activity | 0.68 | U/mg | 10.1039/C6MD00646A |
| Mus musculus | Mus musculus | Activity | 0.79 | U/mg | 10.1039/C6MD00646A |
| Mus musculus | Mus musculus | Activity | 1.13 | mg/g | 10.1039/C6MD00646A |
| Mus musculus | Mus musculus | Activity | 1.18 | mg/g | 10.1039/C6MD00646A |
| Mus musculus | Mus musculus | Activity | 1.35 | mg/g | 10.1039/C6MD00646A |
| Mus musculus | Mus musculus | Activity | 1.64 | U/mg | 10.1039/C6MD00646A |
| Mus musculus | Mus musculus | Activity | 1.72 | mg/g | 10.1039/C6MD00646A |
| Mus musculus | Mus musculus | Activity | 1.79 | U/mg | 10.1039/C6MD00646A |
| Mus musculus | Mus musculus | Activity | 2.88 | nmol/ml | 10.1039/C6MD00646A |
| Mus musculus | Mus musculus | Activity | 3.05 | nmol/ml | 10.1039/C6MD00646A |
| Mus musculus | Mus musculus | Activity | 3.74 | nmol/ml | 10.1039/C6MD00646A |
| Mus musculus | Mus musculus | Activity | 3.95 | nmol/ml | 10.1039/C6MD00646A |
| Mus musculus | Mus musculus | Activity | 4.19 | mg/g | 10.1039/C6MD00646A |
| Mus musculus | Mus musculus | Activity | 4.84 | mg/g | 10.1039/C6MD00646A |
| Mus musculus | Mus musculus | Activity | 5.23 | mg/g | 10.1039/C6MD00646A |
| Mus musculus | Mus musculus | Activity | 5.38 | mg/g | 10.1039/C6MD00646A |
| Mus musculus | Mus musculus | Activity | 10.74 | pg/ml | 10.1039/C6MD00646A |
| Mus musculus | Mus musculus | Activity | 12.07 | pg/ml | 10.1039/C6MD00646A |
| Mus musculus | Mus musculus | Activity | 13.81 | pg/ml | 10.1039/C6MD00646A |
| Mus musculus | Mus musculus | Activity | 14.16 | pg/ml | 10.1039/C6MD00646A |
| Mus musculus | Mus musculus | Activity | 14.51 | pg/ml | 10.1039/C6MD00646A |
| Mus musculus | Mus musculus | Activity | 16.03 | pg/ml | 10.1039/C6MD00646A |
| Mus musculus | Mus musculus | Activity | 17.66 | pg/ml | 10.1039/C6MD00646A |
| Mus musculus | Mus musculus | Activity | 18.27 | pg/ml | 10.1039/C6MD00646A |
| Mus musculus | Mus musculus | Activity | 32.32 | U/mg | 10.1039/C6MD00646A |
| Mus musculus | Mus musculus | Activity | 38.25 | U/mg | 10.1039/C6MD00646A |
| Mus musculus | Mus musculus | Activity | 46.52 | U/mg | 10.1039/C6MD00646A |
| Mus musculus | Mus musculus | Activity | 48.58 | U/mg | 10.1039/C6MD00646A |
| Mus musculus | Mus musculus | Activity | 50.12 | % | 10.1039/C6MD00646A |
| Mus musculus | Mus musculus | Activity | 52.68 | % | 10.1039/C6MD00646A |
| Mus musculus | Mus musculus | Activity | 54.34 | % | 10.1039/C6MD00646A |
| Mus musculus | Mus musculus | Activity | 56.64 | % | 10.1039/C6MD00646A |
| Mus musculus | Mus musculus | Activity | 60.53 | U/mg | 10.1039/C6MD00646A |
| Mus musculus | Mus musculus | Activity | 64.45 | U/mg | 10.1039/C6MD00646A |
| Mus musculus | Mus musculus | Activity | 74.25 | U/mg | 10.1039/C6MD00646A |
| Mus musculus | Mus musculus | Activity | 76.47 | U/mg | 10.1039/C6MD00646A |
| Mus musculus | Mus musculus | Activity | 84.35 | pg/ml | 10.1039/C6MD00646A |
| Mus musculus | Mus musculus | Activity | 98.13 | pg/ml | 10.1039/C6MD00646A |
| Mus musculus | Mus musculus | Activity | 168.32 | pg/ml | 10.1039/C6MD00646A |
| Mus musculus | Mus musculus | Activity | 218.12 | pg/ml | 10.1039/C6MD00646A |
| Mus musculus | Mus musculus | Activity | 743.09 | U/L | 10.1039/C6MD00646A |
| Mus musculus | Mus musculus | Activity | 790.43 | U/L | 10.1039/C6MD00646A |
| Mus musculus | Mus musculus | Activity | 850.44 | U/L | 10.1039/C6MD00646A |
| Mus musculus | Mus musculus | Activity | 878.91 | U/L | 10.1039/C6MD00646A |
| Mus musculus | Mus musculus | Activity | nan | None | 10.1039/C6MD00646A |