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Teleocidin B4

AlkaPlorer ID: AK014135

Synonym: None

IUPAC Name: (6S,9S,14R,17R)-17-ethenyl-6-(hydroxymethyl)-10,14,17-trimethyl-9,14-di(propan-2-yl)-2,7,10-triazatetracyclo[9.7.1.04,19.013,18]nonadeca-1(18),3,11(19),12-tetraen-8-one

Structure

SMILES: C=C[C@@]1(C)CC[C@](C)(C(C)C)C2=CC3=C4C(=CNC4=C21)C[C@@H](CO)NC(=O)[C@H](C(C)C)N3C

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InChI: InChI=1S/C28H41N3O2/c1-9-27(6)10-11-28(7,17(4)5)20-13-21-22-18(14-29-24(22)23(20)27)12-19(15-32)30-26(33)25(16(2)3)31(21)8/h9,13-14,16-17,19,25,29,32H,1,10-12,15H2,2-8H3,(H,30,33)/t19-,25-,27-,28+/m0/s1

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InChIKey: PEYTUVXFLCCGCC-YGHSORLUSA-N

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Source

Species Genus Family Order Class Phylum Kingdom Domain

Properties Information

Molecule Weight: 451.6550000000002

TPSA？: 68.36

MolLogP？: 4.813100000000004

Number of H-Donors: 3

Number of H-Acceptors: 3

RingCount: 4

Activities Information

Organism Target Name Standard Type Standard Value Standard Units doi
Homo sapiens HeLa Activity 1.19 cpm 10.1021/np50105a005
Homo sapiens HeLa Activity 1.82 cpm 10.1021/np50105a005
Homo sapiens HeLa Activity 6.72 cpm 10.1021/np50105a005
Homo sapiens HeLa Activity 7.46 cpm 10.1021/np50105a005
Homo sapiens HL-60 EC50 5.0 nM 10.1021/jm970704s
Homo sapiens HL-60 ED50 1.2 M l-1 10.1021/jm00090a016
Homo sapiens Protein kinase C delta Ki 0.32 nM 10.1021/jm970704s
Mus musculus Protein kinase C eta Ki 0.1 nM 10.1016/0960-894X(96)00026-1
Rattus norvegicus Protein kinase C gamma Ki 2.0 nM 10.1016/0960-894X(96)00026-1
None Unchecked IC50 588843655.36 nM 10.1021/np50105a005

Metabolism Information