O,N-Dimethylnandigerine
AlkaPlorer ID: AK014362
Synonym: '', 'O-Methylbulbocapnine'
IUPAC Name: (12S)-17,18-dimethoxy-11-methyl-3,5-dioxa-11-azapentacyclo[10.7.1.02,6.08,20.014,19]icosa-1(20),2(6),7,14(19),15,17-hexaene
Structure
SMILES: COC1=C(OC)C2=C(C=C1)C[C@H]1C3=C(C=C4OCOC4=C23)CCN1C
InChI: InChI=1S/C20H21NO4/c1-21-7-6-12-9-15-20(25-10-24-15)18-16(12)13(21)8-11-4-5-14(22-2)19(23-3)17(11)18/h4-5,9,13H,6-8,10H2,1-3H3/t13-/m0/s1
InChIKey: GDVPELGSXTWKDA-ZDUSSCGKSA-N
Reference
Northalifoline, a New Isoquinolone Alkaloid from the Pedicels of Lindera megaphylla
PubChem CID: 10246564
LOTUS: LTS0076171
SuperNatural Ⅲ: SN0103060-02
NPASS: NPC247389
Source
Properties Information
Molecule Weight: 339.39100000000013
TPSA？: 40.16
MolLogP？: 3.184600000000001
Number of H-Donors: 0
Number of H-Acceptors: 5
RingCount: 5
Activities Information
| Organism | Target Name | Standard Type | Standard Value | Standard Units | doi |
|---|---|---|---|---|---|
| Homo sapiens | Sclerostin | IC50 | 1500.0 | nM | None |
| Rattus norvegicus | Aorta | Activity | 22.9 | % | 10.1021/np50123a013 |
| Rattus norvegicus | Aorta | Activity | 55.2 | % | 10.1021/np50123a013 |
| Rattus norvegicus | Aorta | Activity | 68.1 | % | 10.1021/np50123a013 |
| Rattus norvegicus | Aorta | Activity | 88.5 | % | 10.1021/np50123a013 |
| None | NON-PROTEIN TARGET | Activity | 0.0 | % | 10.1021/np9700735 |
| None | NON-PROTEIN TARGET | Activity | 47.9 | % | 10.1021/np9700735 |
| None | NON-PROTEIN TARGET | Activity | 50.4 | % | 10.1021/np9700735 |
| None | NON-PROTEIN TARGET | Activity | 72.5 | % | 10.1021/np9700735 |
| None | NON-PROTEIN TARGET | Activity | 75.1 | % | 10.1021/np9700735 |
| None | NON-PROTEIN TARGET | Activity | 83.4 | % | 10.1021/np9700735 |
| None | Platelet | Activity | 60.8 | % | 10.1021/np50123a013 |
| None | Platelet | Activity | 73.0 | % | 10.1021/np50123a013 |