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6-{[4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy}-14-ethyl-12,13-dihydroxy-4-[(5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl)oxy]-7-methoxy-3,5,7,9,11,13-hexamethyl-1-oxacyclotetradecane-2,10-dione

AlkaPlorer ID: AK014705

Synonym: None

IUPAC Name: (3R,4S,5S,6R,7R,9R,11R,12R,13S,14R)-6-[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-14-ethyl-12,13-dihydroxy-4-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-7-methoxy-3,5,7,9,11,13-hexamethyl-oxacyclotetradecane-2,10-dione

Structure

SMILES: CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O

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InChI: InChI=1S/C38H69NO13/c1-15-26-38(10,45)31(42)21(4)28(40)19(2)17-37(9,47-14)33(52-35-29(41)25(39(11)12)16-20(3)48-35)22(5)30(23(6)34(44)50-26)51-27-18-36(8,46-13)32(43)24(7)49-27/h19-27,29-33,35,41-43,45H,15-18H2,1-14H3/t19-,20-,21+,22+,23-,24+,25+,26-,27+,29-,30+,31-,32+,33-,35+,36-,37-,38-/m1/s1

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InChIKey: AGOYDEPGAOXOCK-KCBOHYOISA-N

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Reference

PubChem CID: 84029

CAS: 116836-41-0

NPASS: NPC480239

Properties Information

Molecule Weight: 747.9640000000002

TPSA？: 182.91

MolLogP？: 2.439700000000004

Number of H-Donors: 4

Number of H-Acceptors: 14

RingCount: 3

Activities Information

Organism Target Name Standard Type Standard Value Standard Units doi
Acinetobacter baumannii Acinetobacter baumannii FICI 0.156 None 10.1128/aac.01439-09
Acinetobacter baumannii Acinetobacter baumannii FICI 0.25 None 10.1128/aac.00405-08
Acinetobacter baumannii Acinetobacter baumannii FICI 0.333 None 10.1128/aac.00405-08
Acinetobacter baumannii Acinetobacter baumannii MIC 0.094 ug.mL-1 10.1128/aac.00405-08
Acinetobacter baumannii Acinetobacter baumannii MIC 0.125 ug.mL-1 10.1128/aac.00405-08
Acinetobacter baumannii Acinetobacter baumannii MIC 0.25 ug.mL-1 10.1128/aac.00405-08
Acinetobacter baumannii Acinetobacter baumannii MIC 0.5 ug.mL-1 10.1128/aac.00405-08
Acinetobacter baumannii Acinetobacter baumannii MIC 0.5 ug.mL-1 10.1128/aac.01439-09
Acinetobacter baumannii Acinetobacter baumannii MIC 0.75 ug.mL-1 10.1128/aac.01439-09
Acinetobacter baumannii Acinetobacter baumannii MIC 1.0 ug.mL-1 10.1128/aac.00405-08
Acinetobacter baumannii Acinetobacter baumannii MIC 1.5 ug.mL-1 10.1128/aac.00405-08
Acinetobacter baumannii Acinetobacter baumannii MIC 2.0 ug.mL-1 10.1128/aac.00405-08
Acinetobacter baumannii Acinetobacter baumannii MIC 6.0 ug.mL-1 10.1128/aac.00405-08
Acinetobacter baumannii Acinetobacter baumannii MIC 8.0 ug.mL-1 10.1128/aac.00405-08
Acinetobacter baumannii Acinetobacter baumannii MIC 8.0 ug.mL-1 10.1128/aac.01439-09
Acinetobacter baumannii Acinetobacter baumannii MIC 32.0 ug.mL-1 10.1021/acsmedchemlett.0c00276
Acinetobacter baumannii Acinetobacter baumannii MIC 128.0 ug.mL-1 10.1021/acsmedchemlett.0c00276
Acinetobacter baumannii Acinetobacter baumannii MIC 512.0 ug.mL-1 10.1021/acsmedchemlett.0c00276
Acinetobacter baumannii Acinetobacter baumannii MIC 10000.0 nM 10.6019/CHEMBL4513141
Acinetobacter baumannii Acinetobacter baumannii Ratio 12.0 None 10.1128/aac.01439-09
Acinetobacter baumannii Acinetobacter baumannii Ratio 40.0 None 10.1128/aac.00405-08
Acinetobacter baumannii Acinetobacter baumannii Ratio 50.0 None 10.1128/aac.00405-08
Bacillus anthracis Bacillus anthracis MIC 0.25 ug.mL-1 10.1021/acs.jnatprod.0c01309
Bacillus anthracis Bacillus anthracis MIC 1.3 ug.mL-1 10.1021/np800106x
Bacillus subtilis Bacillus subtilis Activity nan None 10.1021/np010126p
Bacillus subtilis Bacillus subtilis MBC 128.0 ug ml-1 10.1016/j.bmcl.2019.126850
Bacillus subtilis Bacillus subtilis MIC 0.125 ug.mL-1 10.1021/acs.jnatprod.2c00020
Bacillus subtilis Bacillus subtilis MIC 0.25 ug.mL-1 10.1016/j.bmcl.2017.07.017
Bacillus subtilis Bacillus subtilis MIC 0.25 ug.mL-1 10.1016/j.bmcl.2018.06.006
Bacillus subtilis Bacillus subtilis MIC 0.25 ug.mL-1 10.1016/j.bmcl.2018.09.012
Bacillus subtilis Bacillus subtilis MIC 0.25 ug.mL-1 10.1016/j.bmcl.2019.126850
Bacillus subtilis Bacillus subtilis MIC 0.25 ug.mL-1 10.1016/j.bmcl.2021.128110
Bacillus subtilis Bacillus subtilis MIC 0.25 ug.mL-1 10.1016/j.bmcl.2021.128330
Bacillus subtilis Bacillus subtilis MIC 0.25 ug.mL-1 10.1016/j.ejmech.2016.10.065
Bacillus subtilis Bacillus subtilis MIC 0.25 ug.mL-1 10.1016/j.ejmech.2019.07.022
Bacillus subtilis Bacillus subtilis MIC 1.7 ug.mL-1 10.1021/np800106x
Bacillus subtilis Bacillus subtilis MIC 40.0 nM 10.1021/jm101593u
Bacillus subtilis Bacillus subtilis Ratio 128.0 None 10.1016/j.bmcl.2019.126850
Bacteroides fragilis Bacteroides fragilis Activity nan None 10.1021/np010126p
Bos taurus Progesterone receptor IC50 nan None None
Bos taurus Progesterone receptor Ki nan None None
Burkholderia cepacia Burkholderia cepacia MIC nan None 10.1039/C0MD00251H
Burkholderia pseudomallei Burkholderia pseudomallei MIC 0.5 ug.mL-1 10.1128/aac.01803-09
Burkholderia pseudomallei Burkholderia pseudomallei MIC 2.0 ug.mL-1 10.1128/aac.01803-09
Burkholderia pseudomallei Burkholderia pseudomallei MIC 4.0 ug.mL-1 10.1128/aac.01803-09
Burkholderia pseudomallei Burkholderia pseudomallei MIC 8.0 ug.mL-1 10.1128/aac.01803-09
Burkholderia pseudomallei Burkholderia pseudomallei MIC 16.0 ug.mL-1 10.1128/aac.01803-09
Burkholderia pseudomallei Burkholderia pseudomallei MIC 32.0 ug.mL-1 10.1128/aac.01803-09
Burkholderia pseudomallei Burkholderia pseudomallei MIC 64.0 ug.mL-1 10.1128/aac.01803-09
Burkholderia pseudomallei Burkholderia pseudomallei MIC 128.0 ug.mL-1 10.1128/aac.01803-09
Campylobacter jejuni Campylobacter jejuni FC 16.0 None 10.1128/aac.01592-06
Campylobacter jejuni Campylobacter jejuni FC 32.0 None 10.1128/aac.01592-06
Campylobacter jejuni Campylobacter jejuni MIC 4.0 ug.mL-1 10.1128/aac.01592-06
Campylobacter jejuni Campylobacter jejuni MIC 8.0 ug.mL-1 10.1128/aac.01592-06
Campylobacter jejuni Campylobacter jejuni MIC 64.0 ug.mL-1 10.1128/aac.01592-06
Campylobacter jejuni Campylobacter jejuni MIC 128.0 ug.mL-1 10.1128/aac.01592-06
Campylobacter jejuni Campylobacter jejuni MIC 265.0 ug.mL-1 10.1128/aac.01592-06
Candida albicans Candida albicans Activity nan None 10.1021/np010126p
Candida albicans Candida albicans MIC 10000.0 nM 10.6019/CHEMBL4513141
Cavia porcellus Leukotriene C4 synthase IC50 nan None None
Cavia porcellus Leukotriene C4 synthase Ki nan None None
Cavia porcellus Serotonin 4 (5-HT4) receptor IC50 nan None None
Cavia porcellus Serotonin 4 (5-HT4) receptor Ki nan None None
Chlamydia pneumoniae Chlamydia pneumoniae MBC90 0.06 ug ml-1 10.1128/aac.01343-09
Chlamydia pneumoniae Chlamydia pneumoniae MIC50 0.06 ug.mL-1 10.1128/aac.01343-09
Chlamydia pneumoniae Chlamydia pneumoniae MIC90 0.06 ug.mL-1 10.1128/aac.01343-09
Chlamydia trachomatis Chlamydia trachomatis MBC 0.015 ug ml-1 10.1128/aac.00235-10
Chlamydia trachomatis Chlamydia trachomatis MBC 0.03 ug ml-1 10.1128/aac.00553-10
Chlamydia trachomatis Chlamydia trachomatis MBC 0.06 ug ml-1 10.1128/aac.00553-10
Chlamydia trachomatis Chlamydia trachomatis MBC90 0.06 ug ml-1 10.1128/aac.00235-10
Chlamydia trachomatis Chlamydia trachomatis MBC90 0.06 ug ml-1 10.1128/aac.01343-09
Chlamydia trachomatis Chlamydia trachomatis MIC 0.015 ug.mL-1 10.1128/aac.00235-10
Chlamydia trachomatis Chlamydia trachomatis MIC 0.015 ug.mL-1 10.1128/aac.00553-10
Chlamydia trachomatis Chlamydia trachomatis MIC 0.03 ug.mL-1 10.1128/aac.00553-10
Chlamydia trachomatis Chlamydia trachomatis MIC 0.06 ug.mL-1 10.1128/aac.00553-10
Chlamydia trachomatis Chlamydia trachomatis MIC50 0.06 ug.mL-1 10.1128/aac.01343-09
Chlamydia trachomatis Chlamydia trachomatis MIC90 0.06 ug.mL-1 10.1128/aac.00235-10
Chlamydia trachomatis Chlamydia trachomatis MIC90 0.06 ug.mL-1 10.1128/aac.01343-09
Citrobacter freundii Citrobacter freundii MIC 0.125 ug.mL-1 10.1128/aac.00405-08
Citrobacter freundii Citrobacter freundii Ratio 250.0 None 10.1128/aac.00405-08
Clostridium perfringens Clostridium perfringens MIC 1.0 ug.mL-1 10.1021/jm8000136
Coxiella burnetii Coxiella burnetii MIC 0.5 ug.mL-1 10.1128/aac.01424-08
Coxiella burnetii Coxiella burnetii MIC 1.0 ug.mL-1 10.1128/aac.01424-08
Coxiella burnetii Coxiella burnetii MIC 2.0 ug.mL-1 10.1128/aac.01424-08
Coxiella burnetii Coxiella burnetii MIC 4.0 ug.mL-1 10.1128/aac.01424-08
Cryptococcus neoformans Cryptococcus neoformans MIC 10000.0 nM 10.6019/CHEMBL4513141
Cutibacterium acnes Cutibacterium acnes MIC 0.004 ug.mL-1 10.1021/jm8000136
Cutibacterium acnes Cutibacterium acnes MIC90 0.5 ug.mL-1 10.1016/j.bmc.2016.10.019
Enterobacter cloacae Enterobacter cloacae FICI 0.135 None 10.1128/aac.01439-09
Enterobacter cloacae Enterobacter cloacae MIC 0.047 ug.mL-1 10.1128/aac.00405-08
Enterobacter cloacae Enterobacter cloacae MIC 0.25 ug.mL-1 10.1128/aac.00405-08
Enterobacter cloacae Enterobacter cloacae MIC 0.273 ug.mL-1 10.1128/aac.00405-08
Enterobacter cloacae Enterobacter cloacae MIC 0.38 ug.mL-1 10.1128/aac.00405-08
Enterobacter cloacae Enterobacter cloacae MIC 0.5 ug.mL-1 10.1128/aac.01439-09
Enterobacter cloacae Enterobacter cloacae MIC 1.5 ug.mL-1 10.1128/aac.00405-08
Enterobacter cloacae Enterobacter cloacae MIC 16.0 ug.mL-1 10.1128/aac.01439-09
Enterobacter cloacae Enterobacter cloacae MIC 32.0 ug.mL-1 10.1128/aac.00405-08
Enterobacter cloacae Enterobacter cloacae MIC 48.0 ug.mL-1 10.1128/aac.01439-09
Enterobacter cloacae Enterobacter cloacae MIC 64.0 ug.mL-1 10.1128/aac.00405-08
Enterobacter cloacae Enterobacter cloacae Ratio 64.0 None 10.1128/aac.01439-09
Enterobacter cloacae Enterobacter cloacae Ratio 85.0 None 10.1128/aac.00405-08
Enterobacter cloacae Enterobacter cloacae Ratio 350.0 None 10.1128/aac.00405-08
Enterobacter cloacae Enterobacter cloacae Ratio 500.0 None 10.1128/aac.00405-08
Enterococcus Enterococcus MIC50 1.2 ug.mL-1 10.1021/jm980240d
Enterococcus Enterococcus MIC50 nan ug.mL-1 10.1021/jm980240d
Enterococcus Enterococcus MIC90 10.0 ug.mL-1 10.1021/jm980240d
Enterococcus Enterococcus MIC90 nan ug.mL-1 10.1021/jm980240d
Enterococcus faecalis Enterococcus faecalis MBC50 16.0 mg/L 10.1128/aac.00666-06
Enterococcus faecalis Enterococcus faecalis MBC50 32.0 mg/L 10.1128/aac.00666-06
Enterococcus faecalis Enterococcus faecalis MBC90 128.0 mg/L 10.1128/aac.00666-06
Enterococcus faecalis Enterococcus faecalis MIC 0.2 ug.mL-1 10.1016/s0960-894x(98)00335-7
Enterococcus faecalis Enterococcus faecalis MIC 0.78 ug.mL-1 10.1016/j.bmcl.2006.05.104
Enterococcus faecalis Enterococcus faecalis MIC 0.78 ug.mL-1 10.1021/jm051157a
Enterococcus faecalis Enterococcus faecalis MIC 1.0 ug.mL-1 10.1016/j.bmcl.2021.128330
Enterococcus faecalis Enterococcus faecalis MIC 1.56 ug.mL-1 10.1021/jm015566s
Enterococcus faecalis Enterococcus faecalis MIC 2.0 ug.mL-1 10.1016/j.bmcl.2022.129115
Enterococcus faecalis Enterococcus faecalis MIC 50.0 ug.mL-1 10.1016/j.bmcl.2006.05.104
Enterococcus faecalis Enterococcus faecalis MIC 50.0 ug.mL-1 10.1021/jm051157a
Enterococcus faecalis Enterococcus faecalis MIC 64.0 ug.mL-1 10.1016/j.bmcl.2022.129115
Enterococcus faecalis Enterococcus faecalis MIC50 8.0 ug.mL-1 10.1128/aac.00666-06
Enterococcus faecalis Enterococcus faecalis MIC50 16.0 ug.mL-1 10.1128/aac.00666-06
Enterococcus faecalis Enterococcus faecalis MIC90 32.0 ug.mL-1 10.1128/aac.00666-06
Enterococcus faecalis Enterococcus faecalis MIC90 64.0 ug.mL-1 10.1128/aac.00666-06
Enterococcus faecium Enterococcus faecium MIC 0.05 ug.mL-1 10.1016/S0960-894X(97)00078-4
Enterococcus faecium Enterococcus faecium MIC 256.0 ug.mL-1 10.1016/j.bmcl.2021.128330
Enterococcus sp. Enterococcus sp. Activity 60.3 % 10.1128/aac.01538-07
Enterococcus sp. Enterococcus sp. Activity 61.5 % 10.1128/aac.01538-07
Enterococcus sp. Enterococcus sp. Activity 65.9 % 10.1128/aac.01538-07
Enterococcus sp. Enterococcus sp. Activity 68.6 % 10.1128/aac.01538-07
Enterococcus sp. Enterococcus sp. Activity 70.1 % 10.1128/aac.01538-07
Escherichia coli Escherichia coli AC50 23104.0 nM None
Escherichia coli Escherichia coli Activity 0.0 % 10.1128/aac.00375-07
Escherichia coli Escherichia coli Activity 33.5 % 10.1128/aac.00375-07
Escherichia coli Escherichia coli Activity 55.2 % 10.1128/aac.00375-07
Escherichia coli Escherichia coli Activity 57.5 % 10.1128/aac.00375-07
Escherichia coli Escherichia coli Activity 62.1 % 10.1128/aac.00375-07
Escherichia coli Escherichia coli Activity 66.6 % 10.1128/aac.00086-08
Escherichia coli Escherichia coli Activity 81.8 % 10.1128/aac.00375-07
Escherichia coli Escherichia coli Activity nan None 10.1021/np010126p
Escherichia coli Escherichia coli Activity nan None 10.1128/aac.00375-07
Escherichia coli Escherichia coli Activity nan None 10.1128/aac.01266-07
Escherichia coli Escherichia coli FICI 0.094 None 10.1128/aac.01439-09
Escherichia coli Escherichia coli FICI 0.126 None 10.1128/aac.01439-09
Escherichia coli Escherichia coli FICI 0.137 None 10.1128/aac.00405-08
Escherichia coli Escherichia coli Inhibition nan % 10.1128/aac.00086-08
Escherichia coli Escherichia coli IZ 16.0 mm 10.1016/j.bmc.2016.01.041
Escherichia coli Escherichia coli log10CFU/ml 6.68 None 10.1128/aac.00086-08
Escherichia coli Escherichia coli MBC 3.0 ug ml-1 10.1128/aac.00375-07
Escherichia coli Escherichia coli MIC 0.032 ug.mL-1 10.1128/aac.00405-08
Escherichia coli Escherichia coli MIC 0.047 ug.mL-1 10.1128/aac.00405-08
Escherichia coli Escherichia coli MIC 0.063 ug.mL-1 10.1128/aac.01439-09
Escherichia coli Escherichia coli MIC 0.094 ug.mL-1 10.1128/aac.00405-08
Escherichia coli Escherichia coli MIC 0.094 ug.mL-1 10.1128/aac.01439-09
Escherichia coli Escherichia coli MIC 0.105 ug.mL-1 10.1128/aac.00405-08
Escherichia coli Escherichia coli MIC 0.125 ug.mL-1 10.1128/aac.01439-09
Escherichia coli Escherichia coli MIC 0.19 ug.mL-1 10.1128/aac.00405-08
Escherichia coli Escherichia coli MIC 0.25 ug.mL-1 10.1128/aac.00405-08
Escherichia coli Escherichia coli MIC 0.25 ug.mL-1 10.1128/aac.01439-09
Escherichia coli Escherichia coli MIC 0.39 ug.mL-1 10.1016/S0960-894X(97)00078-4
Escherichia coli Escherichia coli MIC 0.5 ug.mL-1 10.1128/aac.00405-08
Escherichia coli Escherichia coli MIC 0.5 ug.mL-1 10.1128/aac.01439-09
Escherichia coli Escherichia coli MIC 1.0 ug.mL-1 10.1128/aac.00405-08
Escherichia coli Escherichia coli MIC 1.0 ug.mL-1 10.1128/aac.01439-09
Escherichia coli Escherichia coli MIC 2.0 ug.mL-1 10.1016/j.bmcl.2005.12.033
Escherichia coli Escherichia coli MIC 2.0 ug.mL-1 10.1021/acs.jnatprod.2c00020
Escherichia coli Escherichia coli MIC 4.0 ug.mL-1 10.1128/aac.00921-08
Escherichia coli Escherichia coli MIC 12.0 ug.mL-1 10.1128/aac.00405-08
Escherichia coli Escherichia coli MIC 12.0 ug.mL-1 10.1128/aac.01439-09
Escherichia coli Escherichia coli MIC 16.0 ug.mL-1 10.1016/j.bmcl.2018.06.039
Escherichia coli Escherichia coli MIC 16.0 ug.mL-1 10.1021/acs.jnatprod.0c01309
Escherichia coli Escherichia coli MIC 16.0 ug.mL-1 10.1128/aac.00375-07
Escherichia coli Escherichia coli MIC 16.0 ug.mL-1 10.1128/aac.00405-08
Escherichia coli Escherichia coli MIC 16.0 ug.mL-1 10.1128/aac.01439-09
Escherichia coli Escherichia coli MIC 22.0 ug.mL-1 10.1021/acs.jmedchem.7b00204
Escherichia coli Escherichia coli MIC 24.0 ug.mL-1 10.1128/aac.00375-07
Escherichia coli Escherichia coli MIC 32.0 ug.mL-1 10.1007/s00044-012-0429-8
Escherichia coli Escherichia coli MIC 32.0 ug.mL-1 10.1016/j.bmcl.2013.03.057
Escherichia coli Escherichia coli MIC 32.0 ug.mL-1 10.1016/j.bmcl.2018.09.012
Escherichia coli Escherichia coli MIC 32.0 ug.mL-1 10.1016/j.bmcl.2022.129115
Escherichia coli Escherichia coli MIC 32.0 ug.mL-1 10.1016/j.ejmech.2008.03.010
Escherichia coli Escherichia coli MIC 32.0 ug.mL-1 10.1016/j.ejmech.2016.10.065
Escherichia coli Escherichia coli MIC 32.0 ug.mL-1 10.1128/aac.00086-08
Escherichia coli Escherichia coli MIC 32.0 ug.mL-1 10.1128/aac.01439-09
Escherichia coli Escherichia coli MIC 40.0 ug.mL-1 10.1016/s0960-894x(99)00534-x
Escherichia coli Escherichia coli MIC 40.0 ug.mL-1 10.1021/jm980240d
Escherichia coli Escherichia coli MIC 50.0 ug.mL-1 10.1016/S0960-894X(97)00078-4
Escherichia coli Escherichia coli MIC 64.0 ug.mL-1 10.1016/j.bmcl.2007.02.019
Escherichia coli Escherichia coli MIC 64.0 ug.mL-1 10.1016/j.bmcl.2013.03.057
Escherichia coli Escherichia coli MIC 64.0 ug.mL-1 10.1016/j.bmcl.2017.06.044
Escherichia coli Escherichia coli MIC 64.0 ug.mL-1 10.1016/j.bmcl.2017.07.017
Escherichia coli Escherichia coli MIC 64.0 ug.mL-1 10.1016/j.bmcl.2018.06.006
Escherichia coli Escherichia coli MIC 64.0 ug.mL-1 10.1016/j.bmcl.2022.129115
Escherichia coli Escherichia coli MIC 64.0 ug.mL-1 10.1016/j.ejmech.2019.05.075
Escherichia coli Escherichia coli MIC 64.0 ug.mL-1 10.1128/aac.00921-08
Escherichia coli Escherichia coli MIC 64.0 ug.mL-1 10.1128/aac.01439-09
Escherichia coli Escherichia coli MIC 100.0 ug.mL-1 10.1016/S0960-894X(97)00078-4
Escherichia coli Escherichia coli MIC 100.0 ug.mL-1 10.1016/s0960-894x(98)00335-7
Escherichia coli Escherichia coli MIC 128.0 ug.mL-1 10.1016/j.bmcl.2019.126850
Escherichia coli Escherichia coli MIC 128.0 ug.mL-1 10.1016/j.ejmech.2019.07.022
Escherichia coli Escherichia coli MIC 128.0 ug.mL-1 10.1128/aac.00086-08
Escherichia coli Escherichia coli MIC 128.0 ug.mL-1 10.1128/aac.00921-08
Escherichia coli Escherichia coli MIC 512.0 ug.mL-1 10.1128/aac.00921-08
Escherichia coli Escherichia coli MIC 10000.0 nM 10.6019/CHEMBL4513141
Escherichia coli Escherichia coli Ratio 4.0 None 10.1128/aac.00921-08
Escherichia coli Escherichia coli Ratio 64.0 None 10.1128/aac.01439-09
Escherichia coli Escherichia coli Ratio 84.0 None 10.1128/aac.01439-09
Escherichia coli Escherichia coli Ratio 90.0 None 10.1128/aac.00405-08
Escherichia coli Escherichia coli Ratio 170.0 None 10.1128/aac.00405-08
Escherichia coli Escherichia coli Ratio 190.0 None 10.1128/aac.00405-08
Escherichia coli Escherichia coli Ratio 260.0 None 10.1128/aac.00405-08
Finegoldia magna Finegoldia magna MIC 2.0 ug.mL-1 10.1021/jm8000136
Gerbillinae Gerbillinae Ratio 0.0 % 10.1016/s0960-894x(98)00390-4
Gerbillinae Gerbillinae Ratio 100.0 % 10.1016/s0960-894x(98)00390-4
Haemophilus Haemophilus MIC50 1.2 ug.mL-1 10.1021/jm980240d
Haemophilus Haemophilus MIC50 2.5 ug.mL-1 10.1021/jm980240d
Haemophilus Haemophilus MIC90 5.0 ug.mL-1 10.1021/jm980240d
Haemophilus Haemophilus MIC90 10.0 ug.mL-1 10.1021/jm980240d
Haemophilus influenzae Haemophilus influenzae Activity 0.0 % 10.1128/aac.00422-07
Haemophilus influenzae Haemophilus influenzae Activity 0.0 % 10.1128/aac.01548-09
Haemophilus influenzae Haemophilus influenzae Activity 2.0 % 10.1128/aac.00422-07
Haemophilus influenzae Haemophilus influenzae Activity 3.5 % 10.1128/aac.00422-07
Haemophilus influenzae Haemophilus influenzae Activity 5.1 % 10.1128/aac.01548-09
Haemophilus influenzae Haemophilus influenzae Activity 60.8 % 10.1128/aac.00422-07
Haemophilus influenzae Haemophilus influenzae Activity 75.5 % 10.1128/aac.00422-07
Haemophilus influenzae Haemophilus influenzae Activity 79.3 % 10.1128/aac.00422-07
Haemophilus influenzae Haemophilus influenzae Activity 99.3 % 10.1128/aac.01548-09
Haemophilus influenzae Haemophilus influenzae Activity nan None 10.1128/aac.00524-09
Haemophilus influenzae Haemophilus influenzae ED50 100.0 mg.kg-1 10.1021/jm900729s
Haemophilus influenzae Haemophilus influenzae FC 1768.0 None 10.1016/j.ejmech.2020.112222
Haemophilus influenzae Haemophilus influenzae log10CFU/ml 4.6 None 10.1128/aac.00524-09
Haemophilus influenzae Haemophilus influenzae log10CFU/ml 5.8 None 10.1128/aac.00524-09
Haemophilus influenzae Haemophilus influenzae MBC 8.0 ug ml-1 10.1016/j.bmc.2015.08.020
Haemophilus influenzae Haemophilus influenzae MBC 8.0 ug ml-1 10.1016/j.bmcl.2017.02.041
Haemophilus influenzae Haemophilus influenzae MBC 8.0 ug ml-1 10.1016/j.ejmech.2019.02.073
Haemophilus influenzae Haemophilus influenzae MBC 8.0 ug ml-1 10.1016/j.ejmech.2019.03.037
Haemophilus influenzae Haemophilus influenzae MBC 32.0 ug ml-1 10.1016/j.bmcl.2017.02.041
Haemophilus influenzae Haemophilus influenzae MIC 0.06 ug.mL-1 10.1016/j.ejmech.2010.09.060
Haemophilus influenzae Haemophilus influenzae MIC 0.6 ug.mL-1 10.1039/C0MD00251H
Haemophilus influenzae Haemophilus influenzae MIC 0.78 ug.mL-1 10.1016/j.bmcl.2006.05.104
Haemophilus influenzae Haemophilus influenzae MIC 0.78 ug.mL-1 10.1021/jm051157a
Haemophilus influenzae Haemophilus influenzae MIC 1.0 ug.mL-1 10.1016/j.bmcl.2017.02.041
Haemophilus influenzae Haemophilus influenzae MIC 1.56 ug.mL-1 10.1016/j.bmc.2008.01.027
Haemophilus influenzae Haemophilus influenzae MIC 1.8 ug.mL-1 10.1039/C0MD00251H
Haemophilus influenzae Haemophilus influenzae MIC 2.0 ug.mL-1 10.1016/j.bmc.2010.02.017
Haemophilus influenzae Haemophilus influenzae MIC 2.5 ug.mL-1 10.1021/jm980240d
Haemophilus influenzae Haemophilus influenzae MIC 3.13 ug.mL-1 10.1021/jm020568d
Haemophilus influenzae Haemophilus influenzae MIC 4.0 ug.mL-1 10.1016/j.bmc.2015.08.020
Haemophilus influenzae Haemophilus influenzae MIC 4.0 ug.mL-1 10.1016/j.bmcl.2012.06.092
Haemophilus influenzae Haemophilus influenzae MIC 4.0 ug.mL-1 10.1016/j.ejmech.2010.11.004
Haemophilus influenzae Haemophilus influenzae MIC 4.0 ug.mL-1 10.1016/j.ejmech.2019.02.073
Haemophilus influenzae Haemophilus influenzae MIC 4.0 ug.mL-1 10.1016/j.ejmech.2019.03.037
Haemophilus influenzae Haemophilus influenzae MIC 4.0 ug.mL-1 10.1128/aac.00054-10
Haemophilus influenzae Haemophilus influenzae MIC 5.0 ug.mL-1 10.1016/s0960-894x(00)00392-9
Haemophilus influenzae Haemophilus influenzae MIC 5.0 ug.mL-1 10.1016/s0960-894x(99)00534-x
Haemophilus influenzae Haemophilus influenzae MIC 6.25 ug.mL-1 10.1016/j.bmc.2008.01.027
Haemophilus influenzae Haemophilus influenzae MIC 6.25 ug.mL-1 10.1016/j.bmcl.2006.05.104
Haemophilus influenzae Haemophilus influenzae MIC 6.25 ug.mL-1 10.1021/jm015566s
Haemophilus influenzae Haemophilus influenzae MIC 6.25 ug.mL-1 10.1021/jm020568d
Haemophilus influenzae Haemophilus influenzae MIC 6.25 ug.mL-1 10.1021/jm051157a
Haemophilus influenzae Haemophilus influenzae MIC 8.0 ug.mL-1 10.1016/j.bmc.2010.02.017
Haemophilus influenzae Haemophilus influenzae MIC 8.0 ug.mL-1 10.1016/j.bmc.2010.06.048
Haemophilus influenzae Haemophilus influenzae MIC 8.0 ug.mL-1 10.1016/j.bmc.2010.06.049
Haemophilus influenzae Haemophilus influenzae MIC 8.0 ug.mL-1 10.1016/j.bmc.2011.07.010
Haemophilus influenzae Haemophilus influenzae MIC 8.0 ug.mL-1 10.1016/j.bmcl.2007.02.019
Haemophilus influenzae Haemophilus influenzae MIC 8.0 ug.mL-1 10.1016/j.bmcl.2012.03.076
Haemophilus influenzae Haemophilus influenzae MIC 8.0 ug.mL-1 10.1016/j.bmcl.2018.06.039
Haemophilus influenzae Haemophilus influenzae MIC 8.0 ug.mL-1 10.1016/j.ejmech.2010.05.009
Haemophilus influenzae Haemophilus influenzae MIC 8.0 ug.mL-1 10.1016/j.ejmech.2010.09.060
Haemophilus influenzae Haemophilus influenzae MIC 8.0 ug.mL-1 10.1016/j.ejmech.2010.11.004
Haemophilus influenzae Haemophilus influenzae MIC 8.0 ug.mL-1 10.1016/s0960-894x(00)00106-2
Haemophilus influenzae Haemophilus influenzae MIC 8.0 ug.mL-1 10.1128/aac.00054-10
Haemophilus influenzae Haemophilus influenzae MIC 16.0 ug.mL-1 10.1016/j.bmcl.2011.10.101
Haemophilus influenzae Haemophilus influenzae MIC 16.0 ug.mL-1 10.1016/j.bmcl.2017.02.041
Haemophilus influenzae Haemophilus influenzae MIC 16.0 ug.mL-1 10.1016/j.bmcl.2022.128761
Haemophilus influenzae Haemophilus influenzae MIC 16.0 ug.mL-1 10.1016/j.ejmech.2020.112222
Haemophilus influenzae Haemophilus influenzae MIC 16.0 ug.mL-1 10.1021/jm900729s
Haemophilus influenzae Haemophilus influenzae MIC 64.0 ug.mL-1 10.1128/aac.00524-09
Haemophilus influenzae Haemophilus influenzae MIC50 2.0 ug.mL-1 10.1128/aac.01548-09
Haemophilus influenzae Haemophilus influenzae MIC50 8.0 ug.mL-1 10.1128/aac.00054-10
Haemophilus influenzae Haemophilus influenzae MIC50 8.0 ug.mL-1 10.1128/aac.00422-07
Haemophilus influenzae Haemophilus influenzae MIC50 8.0 ug.mL-1 10.1128/aac.00966-09
Haemophilus influenzae Haemophilus influenzae MIC50 12.0 ug.mL-1 10.1128/aac.00960-06
Haemophilus influenzae Haemophilus influenzae MIC50 16.0 ug.mL-1 10.1128/aac.00960-06
Haemophilus influenzae Haemophilus influenzae MIC50/MIC90 nan None 10.1016/s0960-894x(99)00534-x
Haemophilus influenzae Haemophilus influenzae MIC90 4.0 ug.mL-1 10.1128/aac.01548-09
Haemophilus influenzae Haemophilus influenzae MIC90 16.0 ug.mL-1 10.1128/aac.00054-10
Haemophilus influenzae Haemophilus influenzae MIC90 16.0 ug.mL-1 10.1128/aac.00422-07
Haemophilus influenzae Haemophilus influenzae MIC90 16.0 ug.mL-1 10.1128/aac.00966-09
Haemophilus influenzae Haemophilus influenzae MIC90 24.0 ug.mL-1 10.1128/aac.00960-06
Haemophilus influenzae Haemophilus influenzae MIC90 32.0 ug.mL-1 10.1128/aac.00960-06
Haemophilus influenzae Haemophilus influenzae MIC90 32.0 ug.mL-1 10.1128/aac.00966-09
Haemophilus influenzae Haemophilus influenzae MIC90 256.0 ug.mL-1 10.1128/aac.00960-06
Haemophilus influenzae Haemophilus influenzae Ratio 2.0 None 10.1016/j.bmcl.2017.02.041
Haemophilus influenzae Haemophilus influenzae Ratio 2.0 None 10.1016/j.ejmech.2019.03.037
Haemophilus influenzae Haemophilus influenzae Ratio 8.0 None 10.1016/j.bmc.2015.08.020
Haemophilus influenzae Haemophilus influenzae Selectivity ratio 2.0 None 10.1016/j.ejmech.2019.02.073
Helicobacter pylori Helicobacter pylori Activity 2.85 log10CFU 10.1021/acs.jmedchem.1c02045
Helicobacter pylori Helicobacter pylori Activity nan None 10.1128/aac.00145-09
Helicobacter pylori Helicobacter pylori Inhibition 81.9 % 10.1016/j.bmcl.2010.07.094
Helicobacter pylori Helicobacter pylori Inhibition 90.0 % 10.1016/j.bmcl.2010.07.094
Helicobacter pylori Helicobacter pylori Inhibition nan % 10.1016/j.bmcl.2010.07.094
Helicobacter pylori Helicobacter pylori IZ 21.0 mm 10.1016/j.bmcl.2010.07.094
Helicobacter pylori Helicobacter pylori MBC 0.1 ug ml-1 10.1021/jm0208673
Helicobacter pylori Helicobacter pylori MBC 1.6 uM 10.1016/j.bmcl.2010.07.094
Helicobacter pylori Helicobacter pylori MBC 25.0 uM 10.1016/j.bmcl.2010.07.094
Helicobacter pylori Helicobacter pylori MBC 50.0 uM 10.1016/j.bmcl.2010.07.094
Helicobacter pylori Helicobacter pylori MIC 0.008 ug.mL-1 10.1021/acs.jnatprod.1c01163
Helicobacter pylori Helicobacter pylori MIC 0.008 ug.mL-1 10.1128/aac.00445-08
Helicobacter pylori Helicobacter pylori MIC 0.01 ug.mL-1 10.1021/acs.jnatprod.9b00149
Helicobacter pylori Helicobacter pylori MIC 0.02 ug.mL-1 10.1016/j.bmcl.2005.10.045
Helicobacter pylori Helicobacter pylori MIC 0.02 ug.mL-1 10.1128/aac.01242-08
Helicobacter pylori Helicobacter pylori MIC 0.05 ug.mL-1 10.1016/s0960-894x(98)00335-7
Helicobacter pylori Helicobacter pylori MIC 0.05 ug.mL-1 10.1016/s0960-894x(99)00549-1
Helicobacter pylori Helicobacter pylori MIC 0.05 ug.mL-1 10.1021/jm010307o
Helicobacter pylori Helicobacter pylori MIC 0.05 ug.mL-1 10.1021/np010126p
Helicobacter pylori Helicobacter pylori MIC 0.057 ug.mL-1 10.1021/jm000169n
Helicobacter pylori Helicobacter pylori MIC 0.057 ug.mL-1 10.1021/jm010217j
Helicobacter pylori Helicobacter pylori MIC 0.057 ug.mL-1 10.1021/jm9900671
Helicobacter pylori Helicobacter pylori MIC 0.06 ug.mL-1 10.1021/jm020868v
Helicobacter pylori Helicobacter pylori MIC 0.06 ug.mL-1 10.1021/np040188q
Helicobacter pylori Helicobacter pylori MIC 0.063 ug.mL-1 10.1021/jm010307o
Helicobacter pylori Helicobacter pylori MIC 0.1 ug.mL-1 10.1016/s0960-894x(98)00335-7
Helicobacter pylori Helicobacter pylori MIC 0.1 ug.mL-1 10.1016/s0960-894x(99)00549-1
Helicobacter pylori Helicobacter pylori MIC 0.125 ug.mL-1 10.1128/aac.00445-08
Helicobacter pylori Helicobacter pylori MIC 0.2 ug.mL-1 10.1016/s0960-894x(99)00549-1
Helicobacter pylori Helicobacter pylori MIC 0.25 ug.mL-1 10.1128/aac.00445-08
Helicobacter pylori Helicobacter pylori MIC 0.5 ug.mL-1 10.1021/jm010307o
Helicobacter pylori Helicobacter pylori MIC 0.5 ug.mL-1 10.1128/aac.00445-08
Helicobacter pylori Helicobacter pylori MIC 0.78 ug.mL-1 10.1016/j.ejmech.2021.113669
Helicobacter pylori Helicobacter pylori MIC 1.0 ug.mL-1 10.1128/aac.00445-08
Helicobacter pylori Helicobacter pylori MIC 1.25 ug.mL-1 10.1016/j.bmcl.2006.08.043
Helicobacter pylori Helicobacter pylori MIC 2.0 ug.mL-1 10.1021/acs.jnatprod.1c01163
Helicobacter pylori Helicobacter pylori MIC 2.0 ug.mL-1 10.1021/jm010307o
Helicobacter pylori Helicobacter pylori MIC 2.0 ug.mL-1 10.1021/np040188q
Helicobacter pylori Helicobacter pylori MIC 2.0 ug.mL-1 10.1128/aac.00445-08
Helicobacter pylori Helicobacter pylori MIC 25.0 ug.mL-1 10.1016/s0960-894x(98)00390-4
Helicobacter pylori Helicobacter pylori MIC 32.0 ug.mL-1 10.1007/s00044-012-0429-8
Helicobacter pylori Helicobacter pylori MIC 32.0 ug.mL-1 10.1021/np040188q
Helicobacter pylori Helicobacter pylori MIC 50.0 ug.mL-1 10.1016/s0960-894x(99)00549-1
Helicobacter pylori Helicobacter pylori MIC 64.0 ug.mL-1 10.1007/s00044-012-0429-8
Helicobacter pylori Helicobacter pylori MIC 128.0 ug.mL-1 10.1007/s00044-012-0429-8
Helicobacter pylori Helicobacter pylori MIC 256.0 ug.mL-1 10.1128/aac.00145-09
Helicobacter pylori Helicobacter pylori MIC50 1.9 ug.mL-1 10.1016/s0960-894x(98)00726-4
Helicobacter pylori Helicobacter pylori MIC50 128.0 ug.mL-1 10.1007/s00044-012-0429-8
Helicobacter pylori Helicobacter pylori MIC90 8.0 ug.mL-1 10.1016/j.bmcl.2014.04.041
Helicobacter pylori Helicobacter pylori MIC90 128.0 ug.mL-1 10.1007/s00044-012-0429-8
Homo sapiens Acetylcholinesterase AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Acetylcholinesterase IC50 nan None None
Homo sapiens Acetylcholinesterase Ki nan None None
Homo sapiens Adenosine A1 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Adenosine A1 receptor IC50 nan None None
Homo sapiens Adenosine A1 receptor Ki nan None None
Homo sapiens Adenosine A2a receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Adenosine A2a receptor IC50 nan None None
Homo sapiens Adenosine A2a receptor Ki nan None None
Homo sapiens Adenosine A3 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Adenosine A3 receptor IC50 nan None None
Homo sapiens Adenosine A3 receptor Ki nan None None
Homo sapiens Alpha-1a adrenergic receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-1d adrenergic receptor IC50 nan None None
Homo sapiens Alpha-1d adrenergic receptor Ki nan None None
Homo sapiens Alpha-2a adrenergic receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-2a adrenergic receptor IC50 nan None None
Homo sapiens Alpha-2a adrenergic receptor Ki nan None None
Homo sapiens Alpha-2b adrenergic receptor IC50 nan None None
Homo sapiens Alpha-2b adrenergic receptor Ki nan None None
Homo sapiens Alpha-2c adrenergic receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-2c adrenergic receptor IC50 nan None None
Homo sapiens Alpha-2c adrenergic receptor Ki nan None None
Homo sapiens Androgen Receptor AC50 28880.2 nM 10.1038/s41467-023-40064-9
Homo sapiens Angiotensin II type 2 (AT-2) receptor IC50 nan None None
Homo sapiens Angiotensin II type 2 (AT-2) receptor Ki nan None None
Homo sapiens Beta-1 adrenergic receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Beta-1 adrenergic receptor IC50 nan None None
Homo sapiens Beta-1 adrenergic receptor Ki nan None None
Homo sapiens Beta-2 adrenergic receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Beta-2 adrenergic receptor IC50 nan None None
Homo sapiens Beta-2 adrenergic receptor Ki nan None None
Homo sapiens Beta-3 adrenergic receptor IC50 nan None None
Homo sapiens Beta-3 adrenergic receptor Ki nan None None
Homo sapiens Bile salt export pump IC50 133000.0 nM 10.1093/toxsci/kft176
Homo sapiens Bradykinin B2 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Bradykinin B2 receptor IC50 nan None None
Homo sapiens Bradykinin B2 receptor Ki nan None None
Homo sapiens Calcitonin receptor IC50 nan None None
Homo sapiens Calcitonin receptor Ki nan None None
Homo sapiens Canalicular multispecific organic anion transporter 1 IC50 133000.0 nM 10.1093/toxsci/kft176
Homo sapiens Canalicular multispecific organic anion transporter 2 IC50 133000.0 nM 10.1093/toxsci/kft176
Homo sapiens Cannabinoid CB1 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Cannabinoid CB1 receptor IC50 nan None None
Homo sapiens Cannabinoid CB1 receptor Ki nan None None
Homo sapiens Carbonic anhydrase II IC50 nan None None
Homo sapiens Carbonic anhydrase II Ki nan None None
Homo sapiens Caspase-1 IC50 nan None None
Homo sapiens Caspase-1 Ki nan None None
Homo sapiens Cathepsin G IC50 nan None None
Homo sapiens Cathepsin G Ki nan None None
Homo sapiens C-C chemokine receptor type 2 IC50 nan None None
Homo sapiens C-C chemokine receptor type 2 Ki nan None None
Homo sapiens C-C chemokine receptor type 4 IC50 nan None None
Homo sapiens C-C chemokine receptor type 4 Ki nan None None
Homo sapiens C-C chemokine receptor type 5 IC50 nan None None
Homo sapiens C-C chemokine receptor type 5 Ki nan None None
Homo sapiens Cholecystokinin A receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Cholecystokinin A receptor IC50 nan None None
Homo sapiens Cholecystokinin A receptor Ki nan None None
Homo sapiens Cholecystokinin B receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Cyclooxygenase-1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Cyclooxygenase-1 IC50 nan None None
Homo sapiens Cyclooxygenase-1 Ki nan None None
Homo sapiens Cyclooxygenase-2 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Cyclooxygenase-2 IC50 nan None None
Homo sapiens Cyclooxygenase-2 Ki nan None None
Homo sapiens Cysteinyl leukotriene receptor 1 IC50 nan None None
Homo sapiens Cysteinyl leukotriene receptor 1 Ki nan None None
Homo sapiens Cytochrome P450 1A2 IC50 nan None None
Homo sapiens Cytochrome P450 1A2 Inhibition nan % 10.1021/tx300075j
Homo sapiens Cytochrome P450 1A2 Ki nan None None
Homo sapiens Cytochrome P450 2A6 IC50 nan None None
Homo sapiens Cytochrome P450 2A6 Ki nan None None
Homo sapiens Cytochrome P450 2C19 IC50 nan None None
Homo sapiens Cytochrome P450 2C19 Inhibition nan % 10.1021/tx300075j
Homo sapiens Cytochrome P450 2C19 Ki nan None None
Homo sapiens Cytochrome P450 2C9 IC50 nan None None
Homo sapiens Cytochrome P450 2C9 Inhibition nan % 10.1021/tx300075j
Homo sapiens Cytochrome P450 2C9 Ki nan None None
Homo sapiens Cytochrome P450 2D6 IC50 nan None None
Homo sapiens Cytochrome P450 2D6 Inhibition nan % 10.1021/tx300075j
Homo sapiens Cytochrome P450 2D6 Ki nan None None
Homo sapiens Cytochrome P450 2E1 IC50 nan None None
Homo sapiens Cytochrome P450 2E1 Ki nan None None
Homo sapiens Cytochrome P450 3A4 Activity nan None None
Homo sapiens Cytochrome P450 3A4 IC50 nan None None
Homo sapiens Cytochrome P450 3A4 Ki 5490.0 nM 10.2174/138920005774330639
Homo sapiens Cytochrome P450 3A4 Ki nan None None
Homo sapiens Cytochrome P450 3A4 Kinact 0.072 min-1 10.2174/138920005774330639
Homo sapiens Cytochrome P450 3A4 Log 1/Km -1.688 None 10.1016/j.bmcl.2005.06.015
Homo sapiens Cytochrome P450 3A4 Ratio IC50 5.0 None 10.1021/tx300075j
Homo sapiens Delta opioid receptor IC50 nan None None
Homo sapiens Delta opioid receptor Ki nan None None
Homo sapiens Dopamine D1 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine D1 receptor IC50 nan None None
Homo sapiens Dopamine D1 receptor Ki nan None None
Homo sapiens Dopamine D2 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine D2 receptor IC50 nan None None
Homo sapiens Dopamine D2 receptor Ki nan None None
Homo sapiens Dopamine D3 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine D3 receptor IC50 nan None None
Homo sapiens Dopamine D3 receptor Ki nan None None
Homo sapiens Dopamine D4 receptor IC50 nan None None
Homo sapiens Dopamine D4 receptor Ki nan None None
Homo sapiens Dopamine transporter AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine transporter IC50 nan None None
Homo sapiens Dopamine transporter Ki nan None None
Homo sapiens Endothelin receptor ET-A AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Endothelin receptor ET-A IC50 nan None None
Homo sapiens Endothelin receptor ET-A Ki nan None None
Homo sapiens Epidermal growth factor receptor erbB1 IC50 nan None None
Homo sapiens Epidermal growth factor receptor erbB1 Ki nan None None
Homo sapiens Equilibrative nucleoside transporter 1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Estrogen receptor alpha AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Estrogen receptor alpha IC50 nan None None
Homo sapiens Estrogen receptor alpha Ki nan None None
Homo sapiens Estrogen receptor beta IC50 nan None None
Homo sapiens Estrogen receptor beta Ki nan None None
Homo sapiens GABA-A receptor; anion channel Inhibition 18.0 % 10.1021/acsmedchemlett.5b00435
Homo sapiens GABA-A receptor; anion channel Inhibition 45.0 % 10.1021/acsmedchemlett.5b00435
Homo sapiens Geminin Potency 11582.1 nM None
Homo sapiens Ghrelin receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Glucocorticoid receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Glucocorticoid receptor IC50 nan None None
Homo sapiens Glucocorticoid receptor Ki nan None None
Homo sapiens GTP-binding nuclear protein Ran/Importin subunit beta-1/Snurportin-1 Potency 517.4 nM None
Homo sapiens HEK293 CC50 10000.0 nM 10.6019/CHEMBL4513141
Homo sapiens HERG AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens HERG IC50 33113.11 nM 10.1016/s0960-894x(03)00492-x
Homo sapiens HERG IC50 46000.0 nM 10.1016/j.bmcl.2004.06.070
Homo sapiens HERG IC50 58884.37 nM 10.1016/j.bmc.2008.04.028
Homo sapiens HERG IC50 58884.37 nM 10.1016/j.bmcl.2005.03.080
Homo sapiens HERG IC50 58884.37 nM 10.1016/s0960-894x(03)00492-x
Homo sapiens HERG IC50 nan None None
Homo sapiens HERG Ki nan None None
Homo sapiens HFF CC50 260000.0 nM 10.1021/jm101593u
Homo sapiens Histamine H1 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Histamine H1 receptor IC50 nan None None
Homo sapiens Histamine H1 receptor Ki nan None None
Homo sapiens Histamine H2 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Histamine H2 receptor IC50 nan None None
Homo sapiens Histamine H2 receptor Ki nan None None
Homo sapiens Histamine H3 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Histone deacetylase 6 Inhibition -12.69 % 10.6019/CHEMBL4808148
Homo sapiens Histone deacetylase 6 Inhibition -6.63 % 10.6019/CHEMBL4808148
Homo sapiens HMG-CoA reductase IC50 nan None None
Homo sapiens HMG-CoA reductase Ki nan None None
Homo sapiens Homo sapiens AUC 240.0 ng.hr.mL-1 10.1128/aac.00532-07
Homo sapiens Homo sapiens AUC 290.0 ng.hr.mL-1 10.1128/aac.00532-07
Homo sapiens Homo sapiens AUC 350.0 ng.hr.mL-1 10.1128/aac.00532-07
Homo sapiens Homo sapiens AUC 480.0 ng.hr.mL-1 10.1128/aac.00532-07
Homo sapiens Homo sapiens AUC 840.0 ng.hr.mL-1 10.1128/aac.00532-07
Homo sapiens Homo sapiens AUC 920.0 ng.hr.mL-1 10.1128/aac.00532-07
Homo sapiens Homo sapiens AUC 2220.0 ng.hr.mL-1 10.1128/aac.00532-07
Homo sapiens Homo sapiens AUC 2420.0 ng.hr.mL-1 10.1128/aac.00532-07
Homo sapiens Homo sapiens AUC 3630.0 ng.hr.mL-1 10.1128/aac.00532-07
Homo sapiens Homo sapiens AUC 4450.0 ng.hr.mL-1 10.1128/aac.00532-07
Homo sapiens Homo sapiens AUC 7520.0 ng.hr.mL-1 10.1128/aac.01270-08
Homo sapiens Homo sapiens AUC 10590.0 ng.hr.mL-1 10.1128/aac.00532-07
Homo sapiens Homo sapiens AUC 18900.0 ng.hr.mL-1 10.1016/j.bmc.2007.09.044
Homo sapiens Homo sapiens AUC 26810.0 ng.hr.mL-1 10.1128/aac.00532-07
Homo sapiens Homo sapiens AUC 36645.02 ng.hr.mL-1 None
Homo sapiens Homo sapiens AUC 37615.92 ng.hr.mL-1 None
Homo sapiens Homo sapiens AUC 58485.51 ng.hr.mL-1 None
Homo sapiens Homo sapiens AUC 60796.12 ng.hr.mL-1 None
Homo sapiens Homo sapiens CL 4.7 mL.min-1.kg-1 10.1021/jm901371v
Homo sapiens Homo sapiens CL 7.3 mL.min-1.kg-1 10.1021/jm901371v
Homo sapiens Homo sapiens CL 18.7 L/hr 10.1128/aac.00532-07
Homo sapiens Homo sapiens CL 37.2 L/hr 10.1128/aac.00532-07
Homo sapiens Homo sapiens CL_renal 2.6 mL.min-1.kg-1 10.1021/jm901371v
Homo sapiens Homo sapiens Cmax 93.59 nM 10.1128/aac.00532-07
Homo sapiens Homo sapiens Cmax 106.96 nM 10.1128/aac.00532-07
Homo sapiens Homo sapiens Cmax 307.5 nM 10.1128/aac.00532-07
Homo sapiens Homo sapiens Cmax 1042.84 nM 10.1128/aac.01270-08
Homo sapiens Homo sapiens Cmax 1336.97 nM None
Homo sapiens Homo sapiens Cmax 1457.3 nM 10.1128/aac.00532-07
Homo sapiens Homo sapiens Cmax 2673.94 nM None
Homo sapiens Homo sapiens Cmax 2925.29 nM None
Homo sapiens Homo sapiens Cmax 2949.36 nM None
Homo sapiens Homo sapiens Cmax 2954.7 nM 10.1128/aac.00532-07
Homo sapiens Homo sapiens Cmax 3222.1 nM 10.1016/j.bmc.2007.09.044
Homo sapiens Homo sapiens Cmax 4010.91 nM 10.1128/aac.00375-07
Homo sapiens Homo sapiens Cmax 4010.91 nM None
Homo sapiens Homo sapiens Cmax 4649.98 nM None
Homo sapiens Homo sapiens Cmax 5290.39 nM None
Homo sapiens Homo sapiens Cmax 6684.85 nM None
Homo sapiens Homo sapiens DILI_Concern nan None 10.1016/j.drudis.2016.02.015
Homo sapiens Homo sapiens DILI_severity_class 8.0 None 10.1016/j.drudis.2016.02.015
Homo sapiens Homo sapiens Excretion 20.0 % None
Homo sapiens Homo sapiens Excretion 30.0 % None
Homo sapiens Homo sapiens Excretion 40.0 % None
Homo sapiens Homo sapiens F 50.0 % 10.1016/j.bmc.2007.08.060
Homo sapiens Homo sapiens F 50.0 % None
Homo sapiens Homo sapiens F 55.0 % 10.1016/j.bmc.2007.09.044
Homo sapiens Homo sapiens Fa 1.0 None 10.1021/jm901371v
Homo sapiens Homo sapiens Fabs 50.0 % 10.1124/dmd.110.034629
Homo sapiens Homo sapiens fAUC 990.0 ng.hr.mL-1 10.1128/aac.00532-07
Homo sapiens Homo sapiens fAUC 1210.0 ng.hr.mL-1 10.1128/aac.00532-07
Homo sapiens Homo sapiens fAUC 2260.0 ng.hr.mL-1 10.1128/aac.00532-07
Homo sapiens Homo sapiens fAUC 5850.0 ng.hr.mL-1 10.1128/aac.00532-07
Homo sapiens Homo sapiens fCmax 0.31 mg/L 10.1128/aac.00532-07
Homo sapiens Homo sapiens fCmax 0.58 mg/L 10.1128/aac.00532-07
Homo sapiens Homo sapiens F_fraction 0.55 None 10.1021/jm901371v
Homo sapiens Homo sapiens Fg 0.69 None 10.1021/jm901371v
Homo sapiens Homo sapiens Fh 0.8 None 10.1021/jm901371v
Homo sapiens Homo sapiens Ratio AUC 0.29 None 10.1128/aac.00532-07
Homo sapiens Homo sapiens Ratio AUC 0.39 None 10.1128/aac.00532-07
Homo sapiens Homo sapiens Ratio AUC 0.41 None 10.1128/aac.00532-07
Homo sapiens Homo sapiens Ratio AUC 0.42 None 10.1128/aac.00532-07
Homo sapiens Homo sapiens T1/2 1.9 hr 10.1128/aac.00532-07
Homo sapiens Homo sapiens T1/2 2.4 hr 10.1128/aac.00532-07
Homo sapiens Homo sapiens T1/2 3.0 hr None
Homo sapiens Homo sapiens T1/2 3.1 hr 10.1128/aac.00532-07
Homo sapiens Homo sapiens T1/2 3.4 hr 10.1128/aac.00532-07
Homo sapiens Homo sapiens T1/2 3.7 hr 10.1128/aac.00532-07
Homo sapiens Homo sapiens T1/2 3.8 hr 10.1128/aac.00532-07
Homo sapiens Homo sapiens T1/2 3.89 hr 10.1128/aac.01270-08
Homo sapiens Homo sapiens T1/2 4.9 hr 10.1016/j.bmc.2007.09.044
Homo sapiens Homo sapiens T1/2 5.0 hr None
Homo sapiens Homo sapiens Tmax 2.0 hr 10.1016/j.bmc.2007.09.044
Homo sapiens Homo sapiens Tmax 2.0 hr None
Homo sapiens Homo sapiens Tmax 2.5 hr None
Homo sapiens Homo sapiens Tmax 2.6 hr 10.1128/aac.00532-07
Homo sapiens Homo sapiens Tmax 3.0 hr 10.1128/aac.00532-07
Homo sapiens Homo sapiens Tmax 3.2 hr 10.1128/aac.00532-07
Homo sapiens Homo sapiens Tmax 3.8 hr 10.1128/aac.00532-07
Homo sapiens Homo sapiens Tmax 4.0 hr 10.1128/aac.00532-07
Homo sapiens Homo sapiens Tmax 5.0 hr None
Homo sapiens Homo sapiens Tmax 6.118 hr None
Homo sapiens Homo sapiens Tmax 6.235 hr None
Homo sapiens Homo sapiens Tmax 9.588 hr None
Homo sapiens Homo sapiens Tmax 10.98 hr None
Homo sapiens Homo sapiens Vbeta 94.0 l 10.1128/aac.00532-07
Homo sapiens Homo sapiens Vdss 1.5 L.kg-1 10.1021/jm901371v
Homo sapiens Homo sapiens Vdss 126.5 l 10.1128/aac.00532-07
Homo sapiens Interleukin-8 receptor A IC50 nan None None
Homo sapiens Interleukin-8 receptor A Ki nan None None
Homo sapiens Interleukin-8 receptor B IC50 nan None None
Homo sapiens Interleukin-8 receptor B Ki nan None None
Homo sapiens Kappa opioid receptor IC50 nan None None
Homo sapiens Kappa opioid receptor Ki nan None None
Homo sapiens Leukocyte common antigen IC50 nan None None
Homo sapiens Leukocyte common antigen Ki nan None None
Homo sapiens Leukocyte elastase IC50 nan None None
Homo sapiens Leukocyte elastase Ki nan None None
Homo sapiens Liver Stability 91.0 % 10.1016/j.ejmech.2016.09.022
Homo sapiens Liver microsomes Activity nan None 10.1021/tx300075j
Homo sapiens Liver microsomes Stability nan % 10.1021/tx300075j
Homo sapiens MAP kinase ERK1 IC50 nan None None
Homo sapiens MAP kinase ERK1 Ki nan None None
Homo sapiens MAP kinase ERK2 IC50 nan None None
Homo sapiens MAP kinase ERK2 Ki nan None None
Homo sapiens MAP kinase ERK2 Potency 3981.1 nM None
Homo sapiens MAP kinase p38 alpha IC50 nan None None
Homo sapiens MAP kinase p38 alpha Ki nan None None
Homo sapiens Matrix metalloproteinase-1 IC50 nan None None
Homo sapiens Matrix metalloproteinase-1 Ki nan None None
Homo sapiens Matrix metalloproteinase 9 IC50 nan None None
Homo sapiens Matrix metalloproteinase 9 Ki nan None None
Homo sapiens Melanocortin receptor 3 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Melanocortin receptor 3 IC50 nan None None
Homo sapiens Melanocortin receptor 3 Ki nan None None
Homo sapiens Melanocortin receptor 4 IC50 nan None None
Homo sapiens Melanocortin receptor 4 Ki nan None None
Homo sapiens Melanocortin receptor 5 IC50 nan None None
Homo sapiens Melanocortin receptor 5 Ki nan None None
Homo sapiens Monoamine oxidase A AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Monoamine oxidase A IC50 nan None None
Homo sapiens Monoamine oxidase A Ki nan None None
Homo sapiens Motilin receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Multidrug resistance-associated protein 4 IC50 133000.0 nM 10.1093/toxsci/kft176
Homo sapiens Mu opioid receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Mu opioid receptor IC50 nan None None
Homo sapiens Mu opioid receptor Ki nan None None
Homo sapiens Muscarinic acetylcholine receptor M1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Muscarinic acetylcholine receptor M1 IC50 nan None None
Homo sapiens Muscarinic acetylcholine receptor M1 Ki nan None None
Homo sapiens Muscarinic acetylcholine receptor M2 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Muscarinic acetylcholine receptor M2 IC50 nan None None
Homo sapiens Muscarinic acetylcholine receptor M2 Ki nan None None
Homo sapiens Muscarinic acetylcholine receptor M3 IC50 nan None None
Homo sapiens Muscarinic acetylcholine receptor M3 Ki nan None None
Homo sapiens Muscarinic acetylcholine receptor M4 IC50 nan None None
Homo sapiens Muscarinic acetylcholine receptor M4 Ki nan None None
Homo sapiens Muscarinic acetylcholine receptor M5 IC50 nan None None
Homo sapiens Muscarinic acetylcholine receptor M5 Ki nan None None
Homo sapiens NCI-H292 Drug uptake 1.0 % 10.1021/jm101317f
Homo sapiens NCI-H292 Drug uptake 35.0 % 10.1021/jm101317f
Homo sapiens Neurokinin 1 receptor IC50 nan None None
Homo sapiens Neurokinin 1 receptor Ki nan None None
Homo sapiens Neurokinin 2 receptor IC50 nan None None
Homo sapiens Neurokinin 2 receptor Ki nan None None
Homo sapiens Neuronal acetylcholine receptor protein alpha-4 subunit AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Neuropeptide Y receptor type 1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Neuropeptide Y receptor type 1 IC50 nan None None
Homo sapiens Neuropeptide Y receptor type 1 Ki nan None None
Homo sapiens Neuropeptide Y receptor type 2 IC50 nan None None
Homo sapiens Neuropeptide Y receptor type 2 Ki nan None None
Homo sapiens Neutrophil Activity 1.1 % 10.1021/acs.jnatprod.8b00939
Homo sapiens Neutrophil Activity 13.3 % 10.1021/acs.jnatprod.8b00939
Homo sapiens Neutrophil Activity 33.7 % 10.1021/acs.jnatprod.8b00939
Homo sapiens Neutrophil Activity 39.0 % 10.1021/acs.jnatprod.8b00939
Homo sapiens Neutrophil Activity 49.8 % 10.1021/acs.jnatprod.8b00939
Homo sapiens Neutrophil Inhibition nan % 10.1021/acs.jnatprod.8b00939
Homo sapiens Norepinephrine transporter AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Norepinephrine transporter IC50 nan None None
Homo sapiens Norepinephrine transporter Ki nan None None
Homo sapiens P-glycoprotein 1 Activity nan None 10.1124/dmd.32.8.828
Homo sapiens P-glycoprotein 1 Activity nan None 10.1124/jpet.104.069583
Homo sapiens P-glycoprotein 1 Activity nan None None
Homo sapiens P-glycoprotein 1 IC50 3800.0 nM 10.1006/bbrc.2001.6000
Homo sapiens P-glycoprotein 1 IC50 7200.0 nM 10.1006/bbrc.2001.6000
Homo sapiens P-glycoprotein 1 IC50 15100.0 nM 10.1006/bbrc.2001.6000
Homo sapiens P-glycoprotein 1 IC50 23800.0 nM 10.1006/bbrc.2001.6000
Homo sapiens P-glycoprotein 1 IC50 50200.0 nM 10.1006/bbrc.2001.6000
Homo sapiens P-glycoprotein 1 IC50 56100.0 nM 10.1006/bbrc.2001.6000
Homo sapiens P-glycoprotein 1 IC50 86700.0 nM 10.1006/bbrc.2001.6000
Homo sapiens P-glycoprotein 1 % maximum response 2.71 % None
Homo sapiens P-glycoprotein 1 Papp 10.8 nm/s None
Homo sapiens P-glycoprotein 1 Papp 336.0 nm/s None
Homo sapiens P-glycoprotein 1 Ratio 6.23 None 10.1021/acs.jmedchem.0c02011
Homo sapiens P-glycoprotein 1 Ratio_ATPase activity 3.55 None None
Homo sapiens P-glycoprotein 1 Ratio_Papp 31.3 None None
Homo sapiens Phosphodiesterase 3A AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Phosphodiesterase 4A AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Phosphodiesterase 4D AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Phosphodiesterase 5A IC50 nan None None
Homo sapiens Phosphodiesterase 5A Ki nan None None
Homo sapiens Plasma PPB 11.0 % 10.1016/j.ejmech.2016.09.022
Homo sapiens Plasma PPB 71.3 % 10.1128/aac.00532-07
Homo sapiens Plasma PPB 76.9 % 10.1128/aac.00532-07
Homo sapiens Platelet activating factor receptor IC50 nan None None
Homo sapiens Platelet activating factor receptor Ki nan None None
Homo sapiens Pregnane X receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Progesterone receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Proteinase-activated receptor 2 Activity nan None 10.1128/aac.01540-08
Homo sapiens Proteinase-activated receptor 2 Inhibition nan % 10.1128/aac.00140-07
Homo sapiens Protein kinase C alpha IC50 nan None None
Homo sapiens Protein kinase C alpha Ki nan None None
Homo sapiens Receptor protein-tyrosine kinase erbB-2 IC50 nan None None
Homo sapiens Receptor protein-tyrosine kinase erbB-2 Ki nan None None
Homo sapiens Serine/threonine protein phosphatase 2B catalytic subunit, alpha isoform IC50 nan None None
Homo sapiens Serine/threonine protein phosphatase 2B catalytic subunit, alpha isoform Ki nan None None
Homo sapiens Serotonin 1a (5-HT1a) receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2a (5-HT2a) receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2a (5-HT2a) receptor IC50 nan None None
Homo sapiens Serotonin 2a (5-HT2a) receptor Ki nan None None
Homo sapiens Serotonin 2b (5-HT2b) receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2b (5-HT2b) receptor IC50 nan None None
Homo sapiens Serotonin 2b (5-HT2b) receptor Ki nan None None
Homo sapiens Serotonin 2c (5-HT2c) receptor IC50 nan None None
Homo sapiens Serotonin 2c (5-HT2c) receptor Ki nan None None
Homo sapiens Serotonin 6 (5-HT6) receptor IC50 nan None None
Homo sapiens Serotonin 6 (5-HT6) receptor Ki nan None None
Homo sapiens Serotonin transporter AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin transporter IC50 nan None None
Homo sapiens Serotonin transporter Ki nan None None
Homo sapiens Sigma opioid receptor IC50 nan None None
Homo sapiens Sigma opioid receptor Ki nan None None
Homo sapiens Solute carrier family 22 member 7 Activity nan None 10.1124/dmd.104.003301
Homo sapiens Solute carrier organic anion transporter family member 1B1 IC50 3090.3 nM 10.1124/mol.112.084152
Homo sapiens Solute carrier organic anion transporter family member 1B1 Inhibition 56.72 % 10.1124/mol.112.084152
Homo sapiens Solute carrier organic anion transporter family member 1B1 Inhibition 73.1 % 10.1021/jm300212s
Homo sapiens Solute carrier organic anion transporter family member 1B3 IC50 3311.31 nM 10.1124/mol.112.084152
Homo sapiens Solute carrier organic anion transporter family member 1B3 Inhibition 53.8 % 10.1021/jm300212s
Homo sapiens Solute carrier organic anion transporter family member 1B3 Inhibition 80.47 % 10.1124/mol.112.084152
Homo sapiens Solute carrier organic anion transporter family member 2B1 Inhibition 5.1 % 10.1021/jm300212s
Homo sapiens THP-1 Drug uptake nan None 10.1128/aac.00203-09
Homo sapiens Thrombin AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Thromboxane A2 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Thromboxane-A synthase IC50 nan None None
Homo sapiens Thromboxane-A synthase Ki nan None None
Homo sapiens Type-1 angiotensin II receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Tyrosine-protein kinase FYN IC50 nan None None
Homo sapiens Tyrosine-protein kinase FYN Ki nan None None
Homo sapiens Tyrosine-protein kinase LCK IC50 nan None None
Homo sapiens Tyrosine-protein kinase LCK Ki nan None None
Homo sapiens Vascular endothelial growth factor receptor 1 IC50 nan None None
Homo sapiens Vascular endothelial growth factor receptor 1 Ki nan None None
Homo sapiens Vasoactive intestinal polypeptide receptor 1 IC50 nan None None
Homo sapiens Vasoactive intestinal polypeptide receptor 1 Ki nan None None
Homo sapiens Vasopressin V1a receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Vasopressin V1a receptor IC50 nan None None
Homo sapiens Vasopressin V1a receptor Ki nan None None
Homo sapiens Vasopressin V2 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Klebsiella oxytoca Klebsiella oxytoca MIC 0.19 ug.mL-1 10.1128/aac.00405-08
Klebsiella oxytoca Klebsiella oxytoca MIC 0.25 ug.mL-1 10.1128/aac.00405-08
Klebsiella oxytoca Klebsiella oxytoca Ratio 250.0 None 10.1128/aac.00405-08
Klebsiella oxytoca Klebsiella oxytoca Ratio 260.0 None 10.1128/aac.00405-08
Klebsiella pneumoniae Klebsiella pneumoniae FICI 0.167 None 10.1128/aac.01439-09
Klebsiella pneumoniae Klebsiella pneumoniae MIC 0.141 ug.mL-1 10.1128/aac.00405-08
Klebsiella pneumoniae Klebsiella pneumoniae MIC 0.19 ug.mL-1 10.1128/aac.00405-08
Klebsiella pneumoniae Klebsiella pneumoniae MIC 0.25 ug.mL-1 10.1128/aac.00405-08
Klebsiella pneumoniae Klebsiella pneumoniae MIC 1.0 ug.mL-1 10.1128/aac.00405-08
Klebsiella pneumoniae Klebsiella pneumoniae MIC 1.0 ug.mL-1 10.1128/aac.01439-09
Klebsiella pneumoniae Klebsiella pneumoniae MIC 2.0 ug.mL-1 10.1128/aac.00405-08
Klebsiella pneumoniae Klebsiella pneumoniae MIC 4.0 ug.mL-1 10.1016/j.bmcl.2021.128330
Klebsiella pneumoniae Klebsiella pneumoniae MIC 4.0 ug.mL-1 10.1128/aac.01439-09
Klebsiella pneumoniae Klebsiella pneumoniae MIC 12.0 ug.mL-1 10.1128/aac.00405-08
Klebsiella pneumoniae Klebsiella pneumoniae MIC 12.0 ug.mL-1 10.1128/aac.01439-09
Klebsiella pneumoniae Klebsiella pneumoniae MIC 24.0 ug.mL-1 10.1128/aac.00405-08
Klebsiella pneumoniae Klebsiella pneumoniae MIC 64.0 ug.mL-1 10.1016/j.bmcl.2013.03.057
Klebsiella pneumoniae Klebsiella pneumoniae MIC 64.0 ug.mL-1 10.1016/j.bmcl.2022.129115
Klebsiella pneumoniae Klebsiella pneumoniae MIC 128.0 ug.mL-1 10.1016/j.bmcl.2018.06.039
Klebsiella pneumoniae Klebsiella pneumoniae MIC 10000.0 nM 10.6019/CHEMBL4513141
Klebsiella pneumoniae Klebsiella pneumoniae Ratio 6.0 None 10.1128/aac.01439-09
Klebsiella pneumoniae Klebsiella pneumoniae Ratio 10.0 None 10.1128/aac.00405-08
Klebsiella pneumoniae Klebsiella pneumoniae Ratio 24.0 None 10.1128/aac.00405-08
Klebsiella pneumoniae Klebsiella pneumoniae Ratio 63.0 None 10.1128/aac.00405-08
Listeria monocytogenes Listeria monocytogenes MIC nan None 10.1128/aac.00203-09
Macaca mulatta Rhesus monkey Activity 89.0 % 10.1021/acsmedchemlett.5b00435
Macaca mulatta Rhesus monkey Activity 108.0 % 10.1021/acsmedchemlett.5b00435
Macaca mulatta Rhesus monkey Inhibition nan % 10.1021/acsmedchemlett.5b00435
Micrococcus luteus Micrococcus luteus Activity nan None 10.1021/np010126p
Micrococcus luteus Micrococcus luteus MIC 0.125 ug.mL-1 10.1021/acs.jnatprod.2c00020
Micrococcus luteus Micrococcus luteus MIC 2.0 ug.mL-1 10.1021/np800106x
Moraxella catarrhalis Moraxella catarrhalis MBC 0.125 ug ml-1 10.1016/j.bmcl.2017.02.041
Moraxella catarrhalis Moraxella catarrhalis MBC 0.125 ug ml-1 10.1016/j.ejmech.2019.03.037
Moraxella catarrhalis Moraxella catarrhalis MBC 0.25 ug ml-1 10.1016/j.bmc.2015.08.020
Moraxella catarrhalis Moraxella catarrhalis MBC 0.25 ug ml-1 10.1016/j.bmcl.2017.02.041
Moraxella catarrhalis Moraxella catarrhalis MIC 0.008 ug.mL-1 10.1016/j.bmcl.2018.06.039
Moraxella catarrhalis Moraxella catarrhalis MIC 0.025 ug.mL-1 10.1016/s0960-894x(98)00335-7
Moraxella catarrhalis Moraxella catarrhalis MIC 0.031 ug.mL-1 10.1016/j.bmcl.2017.02.041
Moraxella catarrhalis Moraxella catarrhalis MIC 0.031 ug.mL-1 10.1016/j.ejmech.2019.03.037
Moraxella catarrhalis Moraxella catarrhalis MIC 0.1 ug.mL-1 10.1016/j.bmc.2008.01.027
Moraxella catarrhalis Moraxella catarrhalis MIC 0.125 ug.mL-1 10.1016/j.bmc.2011.07.010
Moraxella catarrhalis Moraxella catarrhalis MIC 0.125 ug.mL-1 10.1016/j.bmc.2015.08.020
Moraxella catarrhalis Moraxella catarrhalis MIC 0.125 ug.mL-1 10.1016/j.bmcl.2012.03.076
Moraxella catarrhalis Moraxella catarrhalis MIC 0.125 ug.mL-1 10.1016/j.bmcl.2017.02.041
Moraxella catarrhalis Moraxella catarrhalis MIC 0.25 ug.mL-1 10.1016/j.bmcl.2007.02.019
Moraxella catarrhalis Moraxella catarrhalis MIC 4.0 ug.mL-1 10.1016/j.bmcl.2011.10.101
Moraxella catarrhalis Moraxella catarrhalis MIC 256.0 ug.mL-1 10.1016/j.bmcl.2018.06.039
Moraxella catarrhalis Moraxella catarrhalis Ratio 2.0 None 10.1016/j.bmc.2015.08.020
Moraxella catarrhalis Moraxella catarrhalis Ratio 2.0 None 10.1016/j.bmcl.2017.02.041
Moraxella catarrhalis Moraxella catarrhalis Ratio 4.0 None 10.1016/j.bmcl.2017.02.041
Moraxella catarrhalis Moraxella catarrhalis Ratio 4.0 None 10.1016/j.ejmech.2019.03.037
Mus musculus J774.A1 Activity 73.4 None 10.1128/aac.00375-07
Mus musculus J774.A1 Activity 90.0 % 10.1128/aac.00375-07
Mus musculus Liver Stability 100.0 % 10.1016/j.ejmech.2016.09.022
Mus musculus Mus musculus Activity nan None 10.1128/aac.00524-09
Mus musculus Mus musculus AUC 1310.0 ng.hr.mL-1 10.1021/jm020568d
Mus musculus Mus musculus AUC 1767.0 ng.hr.mL-1 10.1021/jm020868v
Mus musculus Mus musculus AUC 30380.0 ng.hr.mL-1 10.1021/jm020568d
Mus musculus Mus musculus Cmax 1336.97 nM 10.1021/jm020868v
Mus musculus Mus musculus Cmax 1617.73 nM 10.1021/jm020568d
Mus musculus Mus musculus Cmax 18824.54 nM 10.1021/jm020568d
Mus musculus Mus musculus ED50 1.4 mg kg-1 day-1 10.1021/jm970547x
Mus musculus Mus musculus ED50 2.0 mg.kg-1 10.1016/s0960-894x(00)00392-9
Mus musculus Mus musculus ED50 6.0 mg.kg-1 10.1016/s0960-894x(99)00534-x
Mus musculus Mus musculus ED50 6.7 mg kg-1 day-1 10.1021/jm970547x
Mus musculus Mus musculus ED50 7.5 mg.kg-1 10.1016/s0960-894x(99)00534-x
Mus musculus Mus musculus ED50 7.6 % 10.1021/jm015566s
Mus musculus Mus musculus ED50 7.6 mg.kg-1 10.1021/jm020568d
Mus musculus Mus musculus ED50 7.6 mg kg-1 day-1 10.1021/jm970547x
Mus musculus Mus musculus ED50 12.0 mg.kg-1 10.1016/s0960-894x(00)00392-9
Mus musculus Mus musculus ED50 12.6 mg.kg-1 10.1021/jm980240d
Mus musculus Mus musculus ED50 13.5 mg.kg-1 10.1021/jm020568d
Mus musculus Mus musculus ED50 14.3 mg kg-1 day-1 10.1021/jm970547x
Mus musculus Mus musculus ED50 16.0 mg.kg-1 10.1016/s0960-894x(99)00534-x
Mus musculus Mus musculus ED50 16.0 mg.kg-1 10.1021/jm980240d
Mus musculus Mus musculus ED50 16.7 mg.kg-1 10.1021/jm0102349
Mus musculus Mus musculus ED50 27.9 mg.kg-1 10.1021/jm0102349
Mus musculus Mus musculus ED50 50.0 mg.kg-1 10.1016/s0960-894x(00)00392-9
Mus musculus Mus musculus ED50 50.0 mg.kg-1 10.1016/s0960-894x(99)00534-x
Mus musculus Mus musculus ED50 50.0 mg.kg-1 10.1021/jm980240d
Mus musculus Mus musculus ED50 55.0 mg.kg-1 10.1016/s0960-894x(99)00534-x
Mus musculus Mus musculus ED50 71.0 mg.kg-1 10.1016/s0960-894x(99)00534-x
Mus musculus Mus musculus ED50 100.0 mg.kg-1 10.1021/jm980240d
Mus musculus Mus musculus ED50 109.0 mg.kg-1 10.1021/jm980240d
Mus musculus Mus musculus ED50 120.0 mg.kg-1 10.1016/s0960-894x(99)00534-x
Mus musculus Mus musculus ED50 150.0 mg.kg-1 10.1016/s0960-894x(00)00392-9
Mus musculus Mus musculus ED50 300.0 mg.kg-1 10.1016/s0960-894x(99)00534-x
Mus musculus Mus musculus ED50 346.0 mg.kg-1 10.1021/jm980240d
Mus musculus Mus musculus ED50 600.0 mg.kg-1 10.1021/jm980240d
Mus musculus Mus musculus PD50 100.0 mg kg-1 10.1021/jm960436i
Mus musculus Mus musculus Survival rate 50.0 % 10.1021/jm020568d
Mus musculus Mus musculus Survival rate 100.0 % 10.1021/jm020568d
Mus musculus Mus musculus Therapeutic efficacy 0.0 None 10.1016/s0960-894x(99)00549-1
Mus musculus Nitric oxide synthase, inducible IC50 nan None None
Mus musculus Nitric oxide synthase, inducible Ki nan None None
Mus musculus P-glycoprotein 3 Activity nan None 10.1046/j.1440-1681.2000.03308.x
Mus musculus Plasma PPB 12.0 % 10.1016/j.ejmech.2016.09.022
Mycobacterium avium Mycobacterium avium GI 98.0 % 10.1016/j.bmc.2013.06.027
Mycobacterium avium Mycobacterium avium GI 100.0 % 10.1016/j.bmc.2012.05.004
Mycobacterium avium Mycobacterium avium GI 100.0 % 10.1016/j.bmc.2016.09.008
Mycobacterium avium Mycobacterium avium GI 100.0 % 10.1016/j.bmcl.2011.11.114
Mycobacterium avium Mycobacterium avium Inhibition 95.0 % 10.1016/j.bmc.2006.12.032
Mycobacterium avium Mycobacterium avium Inhibition 95.0 % 10.1021/jm058167w
Mycobacterium avium Mycobacterium avium Inhibition 95.0 % 10.1021/jm0703901
Mycobacterium avium Mycobacterium avium Inhibition 95.0 % 10.1021/jm070391t
Mycobacterium avium Mycobacterium avium log10cfu 5.0 None 10.1128/aac.00689-09
Mycobacterium avium Mycobacterium avium log10cfu 6.0 None 10.1128/aac.00689-09
Mycobacterium avium Mycobacterium avium log10cfu 6.2 None 10.1128/aac.00689-09
Mycobacterium avium Mycobacterium avium log10cfu 6.6 None 10.1128/aac.00689-09
Mycobacterium avium Mycobacterium avium log10cfu 7.1 None 10.1128/aac.00410-07
Mycobacterium avium Mycobacterium avium log10cfu 7.2 None 10.1128/aac.00689-09
Mycobacterium avium Mycobacterium avium log10cfu 8.12 None 10.1128/aac.00410-07
Mycobacterium avium Mycobacterium avium MIC 0.2 ug.mL-1 10.1016/j.ejmech.2006.08.007
Mycobacterium avium Mycobacterium avium MIC 2.0 ug.mL-1 10.1128/aac.00410-07
Mycobacterium avium Mycobacterium avium MIC 4.0 ug.mL-1 10.1016/j.ejmech.2017.09.014
Mycobacterium avium Mycobacterium avium MIC 8.0 ug.mL-1 10.1016/j.ejmech.2017.09.014
Mycobacterium avium Mycobacterium avium MIC 16.0 ug.mL-1 10.1016/j.ejmech.2017.09.014
Mycobacterium avium Mycobacterium avium MIC 64.0 ug.mL-1 10.1128/aac.01303-06
Mycobacterium avium Mycobacterium avium MIC 512.0 ug.mL-1 10.1016/j.ejmech.2017.09.014
Mycobacterium avium Mycobacterium avium MIC 1024.0 ug.mL-1 10.1016/j.ejmech.2017.09.014
Mycobacterium avium Mycobacterium avium MIC50 2.0 ug.mL-1 10.1128/aac.01303-06
Mycobacterium avium Mycobacterium avium MIC90 2.0 ug.mL-1 10.1016/j.bmc.2016.03.003
Mycobacterium avium Mycobacterium avium MIC90 2.0 ug.mL-1 10.1021/jm058167w
Mycobacterium avium Mycobacterium avium MIC90 2.0 ug.mL-1 10.1021/jm0703901
Mycobacterium avium Mycobacterium avium MIC90 2.0 ug.mL-1 10.1021/jm070391t
Mycobacterium avium Mycobacterium avium MIC90 4.0 ug.mL-1 10.1128/aac.01303-06
Mycobacterium avium complex sp. Mycobacterium avium complex sp. CFU 2.8 10^7/g 10.1128/aac.01303-06
Mycobacterium avium complex sp. Mycobacterium avium complex sp. CFU 2.8 10^8/g 10.1128/aac.01303-06
Mycobacterium avium complex sp. Mycobacterium avium complex sp. CFU 6.6 10^7/g 10.1128/aac.01303-06
Mycobacterium avium complex sp. Mycobacterium avium complex sp. CFU 8.0 10^8/g 10.1128/aac.01303-06
Mycobacterium avium complex sp. Mycobacterium avium complex sp. log10cfu 2.18 None 10.1128/aac.00410-07
Mycobacterium avium complex sp. Mycobacterium avium complex sp. log10cfu 3.94 None 10.1128/aac.00410-07
Mycobacterium avium complex sp. Mycobacterium avium complex sp. log10cfu 4.06 None 10.1128/aac.00410-07
Mycobacterium avium complex sp. Mycobacterium avium complex sp. log10cfu 4.3 None 10.1128/aac.00410-07
Mycobacterium avium complex sp. Mycobacterium avium complex sp. log10cfu 4.58 None 10.1128/aac.00410-07
Mycobacterium avium complex sp. Mycobacterium avium complex sp. log10cfu 5.03 None 10.1128/aac.00410-07
Mycobacterium avium complex sp. Mycobacterium avium complex sp. log10cfu 5.28 None 10.1128/aac.00410-07
Mycobacterium avium complex sp. Mycobacterium avium complex sp. log10cfu 5.36 None 10.1128/aac.00410-07
Mycobacterium avium complex sp. Mycobacterium avium complex sp. log10cfu 5.91 None 10.1128/aac.00410-07
Mycobacterium avium complex sp. Mycobacterium avium complex sp. MIC 0.5 ug.mL-1 10.1128/aac.00410-07
Mycobacterium avium complex sp. Mycobacterium avium complex sp. MIC 2.0 ug.mL-1 10.1128/aac.00410-07
Mycobacterium avium complex sp. Mycobacterium avium complex sp. MIC90 64.0 ug.mL-1 10.1128/aac.00410-07
Mycobacterium intracellulare Mycobacterium intracellulare log10cfu 3.16 None 10.1128/aac.00410-07
Mycobacterium intracellulare Mycobacterium intracellulare log10cfu 3.17 None 10.1128/aac.00410-07
Mycobacterium intracellulare Mycobacterium intracellulare log10cfu 3.2 None 10.1128/aac.00410-07
Mycobacterium intracellulare Mycobacterium intracellulare MIC 0.5 ug.mL-1 10.1128/aac.00410-07
Mycobacterium tuberculosis Mycobacterium tuberculosis GI nan None 10.1016/j.bmc.2012.05.004
Mycobacterium tuberculosis Mycobacterium tuberculosis GI nan None 10.1016/j.bmcl.2011.11.114
Mycobacterium tuberculosis Mycobacterium tuberculosis Inhibition nan % 10.1016/j.bmc.2006.12.032
Mycobacterium tuberculosis Mycobacterium tuberculosis Inhibition nan % 10.1021/jm070391t
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 1.0 ug.mL-1 10.1016/j.ejmech.2017.06.005
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 1600.0 nM 10.1128/aac.00055-06
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 13400.0 nM 10.1128/aac.00055-06
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 18700.0 nM 10.1128/aac.00055-06
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 128000.0 nM 10.1128/aac.00055-06
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC50 nan None 10.1016/j.bmc.2016.03.003
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC90 nan None 10.1021/jm0703901
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC90 nan None 10.1021/jm070391t
Mycobacterium tuberculosis variant bovis Mycobacterium tuberculosis variant bovis Inhibition nan % 10.1021/jm058167w
Mycobacterium tuberculosis variant bovis Mycobacterium tuberculosis variant bovis MIC 0.07 ug.mL-1 10.1128/aac.01302-08
Mycobacterium tuberculosis variant bovis Mycobacterium tuberculosis variant bovis MIC 0.15 ug.mL-1 10.1128/aac.01302-08
Mycobacterium tuberculosis variant bovis Mycobacterium tuberculosis variant bovis MIC 0.25 ug.mL-1 10.1128/aac.01302-08
Mycobacterium tuberculosis variant bovis Mycobacterium tuberculosis variant bovis MIC 0.3 ug.mL-1 10.1128/aac.01302-08
Mycobacterium tuberculosis variant bovis Mycobacterium tuberculosis variant bovis MIC 2.0 ug.mL-1 10.1128/aac.01302-08
Mycobacterium tuberculosis variant bovis Mycobacterium tuberculosis variant bovis MIC90 nan ug.mL-1 10.1021/jm058167w
Mycobacterium ulcerans Mycobacterium ulcerans Activity nan None 10.1128/aac.00730-07
Mycobacterium ulcerans Mycobacterium ulcerans log10cfu 1.25 None 10.1128/aac.00730-07
Mycobacterium ulcerans Mycobacterium ulcerans log10cfu 2.53 None 10.1128/aac.00730-07
Mycobacterium ulcerans Mycobacterium ulcerans log10cfu 3.43 None 10.1128/aac.00730-07
Mycobacterium ulcerans Mycobacterium ulcerans MIC 0.03 ug.mL-1 10.1128/aac.00400-10
Mycobacterium ulcerans Mycobacterium ulcerans MIC 0.13 ug.mL-1 10.1128/aac.00400-10
Mycobacterium ulcerans Mycobacterium ulcerans MIC 0.25 ug.mL-1 10.1128/aac.00400-10
Mycobacterium ulcerans Mycobacterium ulcerans MIC 0.5 ug.mL-1 10.1128/aac.00730-07
Mycobacteroides abscessus Mycobacteroides abscessus Activity nan None 10.1128/aac.00986-07
Mycobacteroides abscessus Mycobacteroides abscessus log10cfu 0.6 None 10.1128/aac.00986-07
Mycobacteroides abscessus Mycobacteroides abscessus log10cfu 1.0 None 10.1128/aac.00986-07
Mycobacteroides abscessus Mycobacteroides abscessus MBC 16.0 ug ml-1 10.1128/aac.00986-07
Mycobacteroides abscessus Mycobacteroides abscessus MBC 256.0 ug ml-1 10.1128/aac.00986-07
Mycobacteroides abscessus Mycobacteroides abscessus MIC 0.25 ug.mL-1 10.1128/aac.00986-07
Mycobacteroides abscessus Mycobacteroides abscessus MIC 0.5 ug.mL-1 10.1128/aac.01275-08
Mycobacteroides abscessus Mycobacteroides abscessus MIC 1.0 ug.mL-1 10.1128/aac.01275-08
Mycobacteroides abscessus Mycobacteroides abscessus MIC 2.0 ug.mL-1 10.1128/aac.01275-08
Mycobacteroides abscessus Mycobacteroides abscessus MIC 4.0 ug.mL-1 10.1128/aac.01275-08
Mycobacteroides abscessus Mycobacteroides abscessus MIC 8.0 ug.mL-1 10.1128/aac.01275-08
Mycobacteroides abscessus Mycobacteroides abscessus MIC 32.0 ug.mL-1 10.1128/aac.01275-08
Mycobacteroides abscessus Mycobacteroides abscessus MIC50 0.03 ug.mL-1 10.1128/aac.00695-08
Mycobacteroides abscessus Mycobacteroides abscessus MIC90 1.0 ug.mL-1 10.1128/aac.00695-08
Mycobacteroides chelonae Mycobacteroides chelonae MIC 25.0 ug.mL-1 10.1128/aac.00590-09
Mycobacteroides chelonae Mycobacteroides chelonae MIC 50.0 ug.mL-1 10.1128/aac.00590-09
Mycobacteroides chelonae Mycobacteroides chelonae MIC 250.0 ug.mL-1 10.1128/aac.00590-09
Mycobacteroides chelonae Mycobacteroides chelonae MIC50 0.06 ug.mL-1 10.1128/aac.00695-08
Mycobacteroides chelonae Mycobacteroides chelonae MIC90 4.0 ug.mL-1 10.1128/aac.00695-08
Mycolicibacterium fortuitum Mycolicibacterium fortuitum MIC50 2.0 ug.mL-1 10.1128/aac.00695-08
Mycolicibacterium fortuitum Mycolicibacterium fortuitum MIC90 16.0 ug.mL-1 10.1128/aac.00695-08
Mycolicibacterium mageritense Mycolicibacterium mageritense MIC 2.0 ug.mL-1 10.1128/aac.00695-08
Mycolicibacterium peregrinum Mycolicibacterium peregrinum MIC50 0.06 ug.mL-1 10.1128/aac.00695-08
Mycolicibacterium peregrinum Mycolicibacterium peregrinum MIC90 2.0 ug.mL-1 10.1128/aac.00695-08
Mycolicibacterium phlei Mycolicibacterium phlei MIC 0.5 ug.mL-1 10.1021/np800106x
Mycolicibacterium smegmatis Mycolicibacterium smegmatis MIC 0.03 ug.mL-1 10.1128/aac.00695-08
Mycolicibacterium smegmatis Mycolicibacterium smegmatis MIC 0.5 ug.mL-1 10.1021/np800106x
Mycolicibacterium smegmatis Mycolicibacterium smegmatis MIC 0.5 ug.mL-1 10.1128/aac.01275-08
Mycolicibacterium smegmatis Mycolicibacterium smegmatis MIC 2.0 ug.mL-1 10.1128/aac.01275-08
Mycolicibacterium smegmatis Mycolicibacterium smegmatis MIC 16.0 ug.mL-1 10.1128/aac.01275-08
Mycoplasmoides pneumoniae Mycoplasmoides pneumoniae MIC 0.00049 ug.mL-1 10.1128/aac.00779-07
Mycoplasmoides pneumoniae Mycoplasmoides pneumoniae MIC 0.002 ug.mL-1 10.1128/aac.01561-06
Mycoplasmoides pneumoniae Mycoplasmoides pneumoniae MIC 0.004 ug.mL-1 10.1128/aac.01561-06
Mycoplasmoides pneumoniae Mycoplasmoides pneumoniae MIC 0.007 ug.mL-1 10.1128/aac.01684-08
Mycoplasmoides pneumoniae Mycoplasmoides pneumoniae MIC 0.016 ug.mL-1 10.1021/jm8000136
Mycoplasmoides pneumoniae Mycoplasmoides pneumoniae MIC 8.0 ug.mL-1 10.1128/aac.01561-06
Mycoplasmoides pneumoniae Mycoplasmoides pneumoniae MIC 16.0 ug.mL-1 10.1128/aac.00779-07
Mycoplasmoides pneumoniae Mycoplasmoides pneumoniae MIC 32.0 ug.mL-1 10.1128/aac.00779-07
Mycoplasmoides pneumoniae Mycoplasmoides pneumoniae MIC 32.0 ug.mL-1 10.1128/aac.01561-06
Mycoplasmoides pneumoniae Mycoplasmoides pneumoniae MIC50 0.0039 ug.mL-1 10.1128/aac.00779-07
Mycoplasmoides pneumoniae Mycoplasmoides pneumoniae MIC50 64.0 ug.mL-1 10.1128/aac.00779-07
Mycoplasmoides pneumoniae Mycoplasmoides pneumoniae MIC50 128.0 ug.mL-1 10.1128/aac.01684-08
Mycoplasmoides pneumoniae Mycoplasmoides pneumoniae MIC90 0.0078 ug.mL-1 10.1128/aac.00779-07
Mycoplasmoides pneumoniae Mycoplasmoides pneumoniae MIC90 64.0 ug.mL-1 10.1128/aac.00779-07
Mycoplasmoides pneumoniae Mycoplasmoides pneumoniae MIC90 128.0 ug.mL-1 10.1128/aac.01684-08
Neisseria meningitidis Neisseria meningitidis MIC 0.015 ug.mL-1 10.1128/aac.01812-09
Neisseria meningitidis Neisseria meningitidis MIC50 0.03 ug.mL-1 10.1128/aac.01812-09
Neisseria meningitidis Neisseria meningitidis MIC90 0.12 ug.mL-1 10.1128/aac.01812-09
Oryctolagus cuniculus Angiotensin-converting enzyme IC50 nan None None
Oryctolagus cuniculus Angiotensin-converting enzyme Ki nan None None
Oryctolagus cuniculus Arachidonate 15-lipoxygenase IC50 nan None None
Oryctolagus cuniculus Arachidonate 15-lipoxygenase Ki nan None None
Pasteurella multocida Pasteurella multocida MIC 0.39 ug.mL-1 10.1021/jm960436i
Peptoniphilus asaccharolyticus Peptoniphilus asaccharolyticus MIC 128.0 ug.mL-1 10.1021/jm8000136
Peptostreptococcus anaerobius Peptostreptococcus anaerobius MIC 0.004 ug.mL-1 10.1021/jm8000136
Proteus mirabilis Proteus mirabilis MIC 24.0 ug.mL-1 10.1128/aac.00405-08
Proteus mirabilis Proteus mirabilis Ratio 2.0 None 10.1128/aac.00405-08
Proteus vulgaris Proteus vulgaris MIC 24.0 ug.mL-1 10.1128/aac.00405-08
Proteus vulgaris Proteus vulgaris Ratio 2.0 None 10.1128/aac.00405-08
Pseudomonas aeruginosa Pseudomonas aeruginosa Activity nan None 10.1021/np010126p
Pseudomonas aeruginosa Pseudomonas aeruginosa FICI 0.46 None 10.1128/aac.00405-08
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 3.0 ug.mL-1 10.1128/aac.00405-08
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 12.0 ug.mL-1 10.1128/aac.00405-08
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 16.0 ug.mL-1 10.1016/j.bmcl.2021.128110
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 16.0 ug.mL-1 10.1128/aac.00405-08
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 32.0 ug.mL-1 10.1016/j.bmcl.2017.06.044
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 32.0 ug.mL-1 10.1016/j.bmcl.2018.09.012
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 32.0 ug.mL-1 10.1016/j.bmcl.2019.126850
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 32.0 ug.mL-1 10.1016/j.ejmech.2019.07.022
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 32.0 ug.mL-1 10.1128/aac.00405-08
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 48.0 ug.mL-1 10.1128/aac.00405-08
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 64.0 ug.mL-1 10.1007/s00044-012-0429-8
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 64.0 ug.mL-1 10.1016/j.bmcl.2013.03.057
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 64.0 ug.mL-1 10.1016/j.bmcl.2017.07.017
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 64.0 ug.mL-1 10.1016/j.bmcl.2018.06.006
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 64.0 ug.mL-1 10.1016/j.bmcl.2022.129115
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 64.0 ug.mL-1 10.1016/j.ejmech.2008.03.010
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 64.0 ug.mL-1 10.1016/j.ejmech.2016.10.065
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 125.0 ug.mL-1 10.1021/acs.jnatprod.0c01309
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 128.0 ug.mL-1 10.1016/j.bmcl.2013.03.057
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 128.0 ug.mL-1 10.1016/j.bmcl.2018.06.039
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 10000.0 nM 10.6019/CHEMBL4513141
Pseudomonas aeruginosa Pseudomonas aeruginosa Ratio 2.0 None 10.1128/aac.00405-08
Rattus norvegicus Aldose reductase IC50 nan None None
Rattus norvegicus Aldose reductase Ki nan None None
Rattus norvegicus Alpha-1a adrenergic receptor IC50 nan None None
Rattus norvegicus Alpha-1a adrenergic receptor Ki nan None None
Rattus norvegicus Alpha-1b adrenergic receptor IC50 nan None None
Rattus norvegicus Alpha-1b adrenergic receptor Ki nan None None
Rattus norvegicus Androgen Receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Rattus norvegicus Androgen Receptor IC50 nan None None
Rattus norvegicus Androgen Receptor Ki nan None None
Rattus norvegicus Cyclooxygenase-1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Rattus norvegicus GABA-A receptor; anion channel Inhibition nan % 10.1021/acsmedchemlett.5b00435
Rattus norvegicus GABA-A receptor; anion channel Kd 0.64 nM 10.1021/acsmedchemlett.5b00435
Rattus norvegicus GABA-A receptor; anion channel Ki 10000.0 nM 10.1021/acsmedchemlett.5b00435
Rattus norvegicus GABA receptor alpha-1 subunit AC50 30000.0 nM 10.1038/s41467-023-40064-9
Rattus norvegicus Glycine receptor IC50 nan None None
Rattus norvegicus Glycine receptor Ki nan None None
Rattus norvegicus Insulin receptor IC50 nan None None
Rattus norvegicus Insulin receptor Ki nan None None
Rattus norvegicus Liver Stability 92.5 % 10.1016/j.ejmech.2016.09.022
Rattus norvegicus Nitric-oxide synthase, brain IC50 nan None None
Rattus norvegicus Nitric-oxide synthase, brain Ki nan None None
Rattus norvegicus Plasma Fu 0.23 None 10.1021/jm901371v
Rattus norvegicus Plasma PPB 0.0 % 10.1016/j.ejmech.2016.09.022
Rattus norvegicus Plasma PPB 50.0 % 10.1016/j.bmc.2007.09.044
Rattus norvegicus Rattus norvegicus Activity nan None 10.1128/aac.00086-08
Rattus norvegicus Rattus norvegicus ALB 36700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALB 38000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALB 39700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALB 40000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALB 40300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALB 40700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 227.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 256.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 259.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 308.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 322.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 334.83 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALT 46.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALT 54.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALT 55.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALT 56.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALT 58.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALT 60.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AST 67.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AST 70.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AST 72.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AST 74.5 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AST 83.17 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AST 90.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BASO 0.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BASOLE 0.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BILI 1.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BILI 1.5 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BILI 1.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BILI 2.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BUN 83.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BUN 123.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BUN 133.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BUN 135.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BUN 140.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BUN 166.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHLORIDE 98.0 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHLORIDE 98.33 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHLORIDE 98.67 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHLORIDE 99.33 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHLORIDE 99.67 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 643.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 680.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 683.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 711.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 713.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 840.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CK 178.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CK 185.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CK 191.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CK 212.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CK 266.5 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CK 286.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CO2 29670000.0 nM 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CO2 30330000.0 nM 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CO2 34000000.0 nM 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CO2 34670000.0 nM 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CREAT 1.1 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CREAT 1.8 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CREAT 1.9 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CREAT 2.1 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CREAT 2.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CREAT 3.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOS 0.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOS 34.5 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOS 40.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOS 46.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOS 59.33 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOS 91.5 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOSLE 0.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOSLE 0.33 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOSLE 0.5 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOSLE 0.67 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus GLUC 1266.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus GLUC 1330.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus GLUC 1410.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus GLUC 1436.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus GLUC 1610.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus GLUC 1731.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 33.83 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 34.5 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 34.87 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 35.03 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 35.47 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 36.57 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HGB 133700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HGB 134500.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HGB 135300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HGB 136300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HGB 139300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HGB 142000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LDH 101.5 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LDH 105.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LDH 112.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LDH 125.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LDH 127.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LDH 137.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LIPASE 10.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LIPASE 11.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LIPASE 13.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LIPASE 24.17 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LIPASE 28.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYM 7764.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYM 8181.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYM 10830.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYM 13692.67 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYM 13806.33 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYM 14108.83 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYMLE 91.67 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYMLE 93.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYMLE 93.5 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYMLE 94.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYMLE 94.67 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCH 23.37 pg 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCH 24.2 pg 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCH 24.37 pg 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCH 24.73 pg 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCH 25.2 pg 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 382000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 388300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 389000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 389800.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 395300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 400000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 60.03 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 62.07 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 63.07 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 63.7 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 63.73 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 63.77 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONO 0.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONO 32.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONO 81.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONO 82.67 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONO 144.67 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONO 172.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONOLE 0.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONOLE 0.33 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONOLE 0.5 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONOLE 1.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTLE 4.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTLE 4.33 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTLE 5.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTLE 5.83 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTLE 8.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTSG 364.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTSG 435.17 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTSG 556.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTSG 592.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTSG 818.67 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTSG 1301.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOS 96.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOS 106.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOS 108.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOS 111.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOS 115.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 1057330.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 1127330.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 1156330.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 1171670.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 1193330.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 1345000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 6.01 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 6.06 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 6.1 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 6.17 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 6.34 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 6.51 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PROT 58300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PROT 59000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PROT 59300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PROT 59700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PROT 60300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBC 5310000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBC 5530000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBC 5560000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBC 5740000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBC 5840000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBCNUC 0.0 /100WBC 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus SODIUM 140.58 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus SODIUM 141.97 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus SODIUM 142.2 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus SODIUM 142.53 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus SODIUM 142.68 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus SODIUM 144.27 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus Tissue Severity Score nan None 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus URATE 6.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus URATE 7.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus URATE 7.5 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus URATE 12.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus URATE 14.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WBC 8200.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WBC 8730.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WBC 11570.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WBC 14470.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WBC 15100.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WBC 15170.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Serotonin 1a (5-HT1a) receptor IC50 nan None None
Rattus norvegicus Serotonin 1a (5-HT1a) receptor Ki nan None None
Rattus norvegicus Serotonin 1b (5-HT1b) receptor IC50 nan None None
Rattus norvegicus Serotonin 1b (5-HT1b) receptor Ki nan None None
Salmonella enterica subsp. enterica serovar Typhi Salmonella typhi MIC 64.0 ug.mL-1 10.1016/j.bmcl.2013.03.057
Salmonella enterica subsp. enterica serovar Typhimurium Salmonella typhimurium MIC 0.25 ug.mL-1 10.1016/j.ejmech.2012.11.028
Salmonella enterica subsp. enterica serovar Typhimurium Salmonella typhimurium MIC 0.5 ug.mL-1 10.1016/j.ejmech.2012.11.028
Serratia marcescens Serratia marcescens MIC 96.0 ug.mL-1 10.1128/aac.00405-08
Serratia marcescens Serratia marcescens MIC 100.0 ug.mL-1 10.1016/s0960-894x(98)00335-7
Serratia marcescens Serratia marcescens Ratio 2.0 None 10.1128/aac.00405-08
Severe acute respiratory syndrome coronavirus 2 Replicase polyprotein 1ab Inhibition -3.046 % 10.6019/CHEMBL4495564
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Hit score 0.1189 None 10.1101/2020.04.21.054387
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 IC50 19952.62 nM 10.6019/CHEMBL4651402
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 IC50 20000.0 nM 10.6019/CHEMBL4651402
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Inhibition -1.12 % 10.21203/rs.3.rs-23951/v1
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Inhibition -0.09 % 10.6019/CHEMBL4495565
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Inhibition index 0.8598 None 10.1101/2020.04.03.023846
Shigella flexneri Shigella flexneri MIC 0.125 ug.mL-1 10.1021/acs.jnatprod.2c00020
Staphylococcus Staphylococcus MIC 0.03 ug.mL-1 10.1016/j.ejmech.2009.04.030
Staphylococcus Staphylococcus MIC 4.0 ug.mL-1 10.1016/j.ejmech.2009.04.030
Staphylococcus Staphylococcus MIC 64.0 ug.mL-1 10.1016/j.ejmech.2009.04.030
Staphylococcus Staphylococcus MIC 128.0 ug.mL-1 10.1016/j.ejmech.2009.04.030
Staphylococcus aureus Staphylococcus aureus AC50 nan None 10.1128/aac.01662-09
Staphylococcus aureus Staphylococcus aureus Activity 0.84 mg/L 10.1128/aac.00203-09
Staphylococcus aureus Staphylococcus aureus Activity 1.32 mg/L 10.1128/aac.00203-09
Staphylococcus aureus Staphylococcus aureus Activity 16.1 % 10.1128/aac.01538-07
Staphylococcus aureus Staphylococcus aureus Activity 19.5 % 10.1128/aac.01538-07
Staphylococcus aureus Staphylococcus aureus Activity 20.1 % 10.1128/aac.01538-07
Staphylococcus aureus Staphylococcus aureus Activity 23.9 % 10.1128/aac.01538-07
Staphylococcus aureus Staphylococcus aureus Activity 30.0 % 10.1128/aac.01538-07
Staphylococcus aureus Staphylococcus aureus Activity 86.4 % 10.1128/aac.01538-07
Staphylococcus aureus Staphylococcus aureus Activity 89.9 % 10.1128/aac.01538-07
Staphylococcus aureus Staphylococcus aureus Activity 93.9 % 10.1128/aac.01538-07
Staphylococcus aureus Staphylococcus aureus Activity 96.3 % 10.1128/aac.01538-07
Staphylococcus aureus Staphylococcus aureus Activity 100.0 % 10.1128/aac.01538-07
Staphylococcus aureus Staphylococcus aureus AUC 6530.0 ng.hr.mL-1 10.1128/aac.00455-10
Staphylococcus aureus Staphylococcus aureus EC50 0.046 ug.mL-1 10.1128/aac.00203-09
Staphylococcus aureus Staphylococcus aureus EC50 0.8 ug.mL-1 10.1128/aac.00203-09
Staphylococcus aureus Staphylococcus aureus ED50 1.2 mg.kg-1 10.1128/aac.00026-09
Staphylococcus aureus Staphylococcus aureus ED50 7.7 mg.kg-1 10.1128/aac.00026-09
Staphylococcus aureus Staphylococcus aureus ED50 8.7 mg.kg-1 10.1128/aac.00026-09
Staphylococcus aureus Staphylococcus aureus ED50 22.4 mg.kg-1 10.1016/j.ejmech.2016.09.022
Staphylococcus aureus Staphylococcus aureus ED50 22.4 mg kg-1 day-1 10.1021/jm970548p
Staphylococcus aureus Staphylococcus aureus FC 0.11 None 10.1016/j.ejmech.2020.112222
Staphylococcus aureus Staphylococcus aureus FC 57.0 None 10.1016/j.ejmech.2020.112222
Staphylococcus aureus Staphylococcus aureus fCmax 1.15 ug ml-1 10.1128/aac.00455-10
Staphylococcus aureus Staphylococcus aureus IZ 23.0 mm 10.1016/j.bmc.2016.01.041
Staphylococcus aureus Staphylococcus aureus log10cfu -1.41 None 10.1128/aac.00203-09
Staphylococcus aureus Staphylococcus aureus log10cfu -0.18 None 10.1128/aac.00203-09
Staphylococcus aureus Staphylococcus aureus MBC 4.0 ug ml-1 10.1016/j.bmc.2020.115729
Staphylococcus aureus Staphylococcus aureus MBC 4.0 ug ml-1 10.1016/j.ejmech.2018.09.053
Staphylococcus aureus Staphylococcus aureus MBC 16.0 ug ml-1 10.1016/j.bmc.2015.08.020
Staphylococcus aureus Staphylococcus aureus MBC 16.0 ug ml-1 10.1016/j.bmcl.2017.02.041
Staphylococcus aureus Staphylococcus aureus MBC 128.0 ug ml-1 10.1016/j.ejmech.2019.07.022
Staphylococcus aureus Staphylococcus aureus MBC 256.0 ug ml-1 10.1016/j.bmcl.2017.02.041
Staphylococcus aureus Staphylococcus aureus MBC 256.0 ug ml-1 10.1016/j.ejmech.2019.02.073
Staphylococcus aureus Staphylococcus aureus MBC 256.0 ug ml-1 10.1016/j.ejmech.2019.03.037
Staphylococcus aureus Staphylococcus aureus MBC nan None 10.1016/j.bmc.2015.08.020
Staphylococcus aureus Staphylococcus aureus MBC nan None 10.1016/j.bmc.2020.115729
Staphylococcus aureus Staphylococcus aureus MBC50 16.0 mg/L 10.1128/aac.00666-06
Staphylococcus aureus Staphylococcus aureus MBC50 32.0 mg/L 10.1128/aac.00666-06
Staphylococcus aureus Staphylococcus aureus MBC90 64.0 mg/L 10.1128/aac.00666-06
Staphylococcus aureus Staphylococcus aureus MBC90 128.0 mg/L 10.1128/aac.00666-06
Staphylococcus aureus Staphylococcus aureus MBIC 128.0 ug ml-1 10.1128/aac.00455-10
Staphylococcus aureus Staphylococcus aureus MBIC nan None 10.1128/aac.00455-10
Staphylococcus aureus Staphylococcus aureus MIC 0.03 ug.mL-1 10.1016/j.ejmech.2010.11.035
Staphylococcus aureus Staphylococcus aureus MIC 0.03 ug.mL-1 10.1016/j.ejmech.2012.11.028
Staphylococcus aureus Staphylococcus aureus MIC 0.03 ug.mL-1 10.1016/S0960-894X(97)00078-4
Staphylococcus aureus Staphylococcus aureus MIC 0.03 ug.mL-1 10.1021/jm970547x
Staphylococcus aureus Staphylococcus aureus MIC 0.031 ug.mL-1 10.1016/j.bmcl.2018.06.039
Staphylococcus aureus Staphylococcus aureus MIC 0.06 ug.mL-1 10.1016/j.ejmech.2013.08.023
Staphylococcus aureus Staphylococcus aureus MIC 0.063 ug.mL-1 10.1016/j.ejmech.2010.09.060
Staphylococcus aureus Staphylococcus aureus MIC 0.1 ug.mL-1 10.1016/j.bmc.2008.01.027
Staphylococcus aureus Staphylococcus aureus MIC 0.1 ug.mL-1 10.1016/s0960-894x(98)00335-7
Staphylococcus aureus Staphylococcus aureus MIC 0.1 ug.mL-1 10.1021/jm015566s
Staphylococcus aureus Staphylococcus aureus MIC 0.1 ug.mL-1 10.1021/jm020568d
Staphylococcus aureus Staphylococcus aureus MIC 0.12 ug.mL-1 10.1007/s00044-012-0429-8
Staphylococcus aureus Staphylococcus aureus MIC 0.12 ug.mL-1 10.1016/j.bmcl.2017.06.044
Staphylococcus aureus Staphylococcus aureus MIC 0.12 ug.mL-1 10.1016/j.bmcl.2018.06.039
Staphylococcus aureus Staphylococcus aureus MIC 0.12 ug.mL-1 10.1016/j.ejmech.2008.03.010
Staphylococcus aureus Staphylococcus aureus MIC 0.12 ug.mL-1 10.1016/j.ejmech.2009.11.032
Staphylococcus aureus Staphylococcus aureus MIC 0.12 ug.mL-1 10.1016/j.ejmech.2010.11.035
Staphylococcus aureus Staphylococcus aureus MIC 0.12 ug.mL-1 10.1016/j.ejmech.2011.04.004
Staphylococcus aureus Staphylococcus aureus MIC 0.12 ug.mL-1 10.1016/j.ejmech.2012.11.028
Staphylococcus aureus Staphylococcus aureus MIC 0.12 ug.mL-1 10.1016/S0960-894X(97)00078-4
Staphylococcus aureus Staphylococcus aureus MIC 0.12 ug.mL-1 10.1128/aac.01247-08
Staphylococcus aureus Staphylococcus aureus MIC 0.125 ug.mL-1 10.1016/j.bmc.2010.06.048
Staphylococcus aureus Staphylococcus aureus MIC 0.125 ug.mL-1 10.1016/j.bmc.2017.02.041
Staphylococcus aureus Staphylococcus aureus MIC 0.125 ug.mL-1 10.1016/j.bmc.2020.115729
Staphylococcus aureus Staphylococcus aureus MIC 0.125 ug.mL-1 10.1016/j.ejmech.2010.05.008
Staphylococcus aureus Staphylococcus aureus MIC 0.125 ug.mL-1 10.1016/j.ejmech.2018.09.053
Staphylococcus aureus Staphylococcus aureus MIC 0.13 ug.mL-1 10.1016/j.bmc.2010.02.017
Staphylococcus aureus Staphylococcus aureus MIC 0.2 ug.mL-1 10.1016/s0960-894x(00)00106-2
Staphylococcus aureus Staphylococcus aureus MIC 0.2 ug.mL-1 10.1016/S0960-894X(97)00078-4
Staphylococcus aureus Staphylococcus aureus MIC 0.2 ug.mL-1 10.1021/jm0102349
Staphylococcus aureus Staphylococcus aureus MIC 0.2 ug.mL-1 10.1021/jm015566s
Staphylococcus aureus Staphylococcus aureus MIC 0.2 ug.mL-1 10.1021/jm020568d
Staphylococcus aureus Staphylococcus aureus MIC 0.25 ug.mL-1 10.1016/j.bmc.2011.07.010
Staphylococcus aureus Staphylococcus aureus MIC 0.25 ug.mL-1 10.1016/j.bmcl.2007.02.019
Staphylococcus aureus Staphylococcus aureus MIC 0.25 ug.mL-1 10.1016/j.bmcl.2007.03.107
Staphylococcus aureus Staphylococcus aureus MIC 0.25 ug.mL-1 10.1016/j.bmcl.2010.07.072
Staphylococcus aureus Staphylococcus aureus MIC 0.25 ug.mL-1 10.1016/j.bmcl.2012.03.076
Staphylococcus aureus Staphylococcus aureus MIC 0.25 ug.mL-1 10.1016/j.bmcl.2012.10.064
Staphylococcus aureus Staphylococcus aureus MIC 0.25 ug.mL-1 10.1016/j.bmcl.2013.01.067
Staphylococcus aureus Staphylococcus aureus MIC 0.25 ug.mL-1 10.1016/j.bmcl.2017.06.044
Staphylococcus aureus Staphylococcus aureus MIC 0.25 ug.mL-1 10.1016/j.bmcl.2017.07.017
Staphylococcus aureus Staphylococcus aureus MIC 0.25 ug.mL-1 10.1016/j.bmcl.2018.06.006
Staphylococcus aureus Staphylococcus aureus MIC 0.25 ug.mL-1 10.1016/j.bmcl.2018.09.012
Staphylococcus aureus Staphylococcus aureus MIC 0.25 ug.mL-1 10.1016/j.bmcl.2019.126850
Staphylococcus aureus Staphylococcus aureus MIC 0.25 ug.mL-1 10.1016/j.bmcl.2021.128110
Staphylococcus aureus Staphylococcus aureus MIC 0.25 ug.mL-1 10.1016/j.bmcl.2021.128330
Staphylococcus aureus Staphylococcus aureus MIC 0.25 ug.mL-1 10.1016/j.bmcl.2022.129115
Staphylococcus aureus Staphylococcus aureus MIC 0.25 ug.mL-1 10.1016/j.ejmech.2010.05.009
Staphylococcus aureus Staphylococcus aureus MIC 0.25 ug.mL-1 10.1016/j.ejmech.2010.09.060
Staphylococcus aureus Staphylococcus aureus MIC 0.25 ug.mL-1 10.1016/j.ejmech.2010.11.004
Staphylococcus aureus Staphylococcus aureus MIC 0.25 ug.mL-1 10.1016/j.ejmech.2012.01.023
Staphylococcus aureus Staphylococcus aureus MIC 0.25 ug.mL-1 10.1016/j.ejmech.2012.10.054
Staphylococcus aureus Staphylococcus aureus MIC 0.25 ug.mL-1 10.1016/j.ejmech.2016.10.065
Staphylococcus aureus Staphylococcus aureus MIC 0.25 ug.mL-1 10.1016/j.ejmech.2019.03.037
Staphylococcus aureus Staphylococcus aureus MIC 0.25 ug.mL-1 10.1016/j.ejmech.2019.07.022
Staphylococcus aureus Staphylococcus aureus MIC 0.25 ug.mL-1 10.1021/acs.jnatprod.0c01309
Staphylococcus aureus Staphylococcus aureus MIC 0.25 ug.mL-1 10.1021/acs.jnatprod.2c00020
Staphylococcus aureus Staphylococcus aureus MIC 0.256 ug.mL-1 10.1128/aac.01173-08
Staphylococcus aureus Staphylococcus aureus MIC 0.3 ug.mL-1 10.1016/s0960-894x(00)00392-9
Staphylococcus aureus Staphylococcus aureus MIC 0.3 ug.mL-1 10.1016/s0960-894x(99)00534-x
Staphylococcus aureus Staphylococcus aureus MIC 0.3 ug.mL-1 10.1021/jm980240d
Staphylococcus aureus Staphylococcus aureus MIC 0.39 ug.mL-1 10.1021/jm970548p
Staphylococcus aureus Staphylococcus aureus MIC 0.4 ug.mL-1 10.1016/j.bmcl.2006.05.104
Staphylococcus aureus Staphylococcus aureus MIC 0.4 ug.mL-1 10.1021/jm051157a
Staphylococcus aureus Staphylococcus aureus MIC 0.5 ug.mL-1 10.1016/j.bmcl.2007.03.107
Staphylococcus aureus Staphylococcus aureus MIC 0.5 ug.mL-1 10.1016/j.bmcl.2010.03.038
Staphylococcus aureus Staphylococcus aureus MIC 0.5 ug.mL-1 10.1016/j.bmcl.2012.12.070
Staphylococcus aureus Staphylococcus aureus MIC 0.5 ug.mL-1 10.1016/j.bmcl.2013.01.067
Staphylococcus aureus Staphylococcus aureus MIC 0.5 ug.mL-1 10.1016/j.ejmech.2010.09.060
Staphylococcus aureus Staphylococcus aureus MIC 0.5 ug.mL-1 10.1016/j.ejmech.2013.08.023
Staphylococcus aureus Staphylococcus aureus MIC 0.5 ug.mL-1 10.1128/aac.00026-09
Staphylococcus aureus Staphylococcus aureus MIC 0.6 ug.mL-1 10.1039/C0MD00251H
Staphylococcus aureus Staphylococcus aureus MIC 0.8 ug.mL-1 10.1021/np800106x
Staphylococcus aureus Staphylococcus aureus MIC 0.9 ug.mL-1 10.1039/C0MD00251H
Staphylococcus aureus Staphylococcus aureus MIC 1.0 ug.mL-1 10.1016/j.bmcl.2013.01.067
Staphylococcus aureus Staphylococcus aureus MIC 1.0 ug.mL-1 10.1016/j.bmcl.2013.09.083
Staphylococcus aureus Staphylococcus aureus MIC 1.0 ug.mL-1 10.1016/j.ejmech.2012.01.023
Staphylococcus aureus Staphylococcus aureus MIC 1.0 ug.mL-1 10.1016/j.ejmech.2012.10.054
Staphylococcus aureus Staphylococcus aureus MIC 1.0 ug.mL-1 10.1128/aac.00026-09
Staphylococcus aureus Staphylococcus aureus MIC 1.0 ug.mL-1 10.1128/aac.00206-09
Staphylococcus aureus Staphylococcus aureus MIC 1.56 ug.mL-1 10.1016/j.bmc.2008.01.027
Staphylococcus aureus Staphylococcus aureus MIC 1.56 ug.mL-1 10.1016/S0960-894X(97)00078-4
Staphylococcus aureus Staphylococcus aureus MIC 2.0 ug.mL-1 10.1016/j.bmcl.2012.10.064
Staphylococcus aureus Staphylococcus aureus MIC 2.0 ug.mL-1 10.1016/j.ejmech.2012.01.023
Staphylococcus aureus Staphylococcus aureus MIC 2.0 ug.mL-1 10.1016/j.ejmech.2012.10.054
Staphylococcus aureus Staphylococcus aureus MIC 3.1 ug.mL-1 10.1016/S0960-894X(97)00078-4
Staphylococcus aureus Staphylococcus aureus MIC 4.0 ug.mL-1 10.1016/j.bmcl.2013.09.083
Staphylococcus aureus Staphylococcus aureus MIC 4.0 ug.mL-1 10.1016/j.ejmech.2010.05.009
Staphylococcus aureus Staphylococcus aureus MIC 6.2 ug.mL-1 10.1016/s0960-894x(00)00106-2
Staphylococcus aureus Staphylococcus aureus MIC 8.0 ug.mL-1 10.1016/j.bmcl.2017.02.041
Staphylococcus aureus Staphylococcus aureus MIC 16.0 ug.mL-1 10.1016/j.bmcl.2013.01.067
Staphylococcus aureus Staphylococcus aureus MIC 16.0 ug.mL-1 10.1016/j.ejmech.2020.112222
Staphylococcus aureus Staphylococcus aureus MIC 16.0 ug.mL-1 10.1128/aac.00206-09
Staphylococcus aureus Staphylococcus aureus MIC 32.0 ug.mL-1 10.1016/j.bmc.2010.06.048
Staphylococcus aureus Staphylococcus aureus MIC 32.0 ug.mL-1 10.1016/j.bmc.2011.07.010
Staphylococcus aureus Staphylococcus aureus MIC 32.0 ug.mL-1 10.1016/j.bmc.2015.08.020
Staphylococcus aureus Staphylococcus aureus MIC 32.0 ug.mL-1 10.1016/j.bmcl.2007.02.019
Staphylococcus aureus Staphylococcus aureus MIC 32.0 ug.mL-1 10.1016/j.bmcl.2010.07.072
Staphylococcus aureus Staphylococcus aureus MIC 32.0 ug.mL-1 10.1016/j.bmcl.2012.10.064
Staphylococcus aureus Staphylococcus aureus MIC 32.0 ug.mL-1 10.1016/j.bmcl.2013.03.057
Staphylococcus aureus Staphylococcus aureus MIC 32.0 ug.mL-1 10.1016/j.bmcl.2013.09.083
Staphylococcus aureus Staphylococcus aureus MIC 32.0 ug.mL-1 10.1016/j.ejmech.2010.11.004
Staphylococcus aureus Staphylococcus aureus MIC 32.0 ug.mL-1 10.1016/j.ejmech.2016.10.065
Staphylococcus aureus Staphylococcus aureus MIC 32.0 ug.mL-1 10.1016/j.ejmech.2019.02.073
Staphylococcus aureus Staphylococcus aureus MIC 32.0 ug.mL-1 10.1016/j.ejmech.2019.03.037
Staphylococcus aureus Staphylococcus aureus MIC 32.0 ug.mL-1 10.1128/aac.00206-09
Staphylococcus aureus Staphylococcus aureus MIC 40.0 ug.mL-1 10.1016/s0960-894x(00)00392-9
Staphylococcus aureus Staphylococcus aureus MIC 40.0 ug.mL-1 10.1016/s0960-894x(99)00534-x
Staphylococcus aureus Staphylococcus aureus MIC 40.0 ug.mL-1 10.1021/jm980240d
Staphylococcus aureus Staphylococcus aureus MIC 50.0 ug.mL-1 10.1016/j.bmcl.2006.05.104
Staphylococcus aureus Staphylococcus aureus MIC 50.0 ug.mL-1 10.1021/jm051157a
Staphylococcus aureus Staphylococcus aureus MIC 64.0 ug.mL-1 10.1016/j.bmc.2010.06.048
Staphylococcus aureus Staphylococcus aureus MIC 64.0 ug.mL-1 10.1016/j.bmc.2010.06.049
Staphylococcus aureus Staphylococcus aureus MIC 64.0 ug.mL-1 10.1016/j.bmc.2011.07.010
Staphylococcus aureus Staphylococcus aureus MIC 64.0 ug.mL-1 10.1016/j.bmc.2015.08.020
Staphylococcus aureus Staphylococcus aureus MIC 64.0 ug.mL-1 10.1016/j.bmc.2017.02.041
Staphylococcus aureus Staphylococcus aureus MIC 64.0 ug.mL-1 10.1016/j.bmc.2020.115729
Staphylococcus aureus Staphylococcus aureus MIC 64.0 ug.mL-1 10.1016/j.bmcl.2017.07.017
Staphylococcus aureus Staphylococcus aureus MIC 64.0 ug.mL-1 10.1016/j.bmcl.2018.06.039
Staphylococcus aureus Staphylococcus aureus MIC 64.0 ug.mL-1 10.1016/j.bmcl.2018.09.012
Staphylococcus aureus Staphylococcus aureus MIC 64.0 ug.mL-1 10.1016/j.bmcl.2022.128761
Staphylococcus aureus Staphylococcus aureus MIC 64.0 ug.mL-1 10.1016/j.ejmech.2010.05.008
Staphylococcus aureus Staphylococcus aureus MIC 64.0 ug.mL-1 10.1016/j.ejmech.2010.05.009
Staphylococcus aureus Staphylococcus aureus MIC 64.0 ug.mL-1 10.1016/j.ejmech.2013.08.023
Staphylococcus aureus Staphylococcus aureus MIC 64.0 ug.mL-1 10.1016/j.ejmech.2020.112222
Staphylococcus aureus Staphylococcus aureus MIC 64.0 ug.mL-1 10.1128/aac.00026-09
Staphylococcus aureus Staphylococcus aureus MIC 64.0 ug.mL-1 10.1128/aac.00206-09
Staphylococcus aureus Staphylococcus aureus MIC 100.0 ug.mL-1 10.1016/j.bmc.2008.01.027
Staphylococcus aureus Staphylococcus aureus MIC 100.0 ug.mL-1 10.1016/S0960-894X(97)00078-4
Staphylococcus aureus Staphylococcus aureus MIC 100.0 ug.mL-1 10.1021/jm015566s
Staphylococcus aureus Staphylococcus aureus MIC 100.0 ug.mL-1 10.1021/jm020568d
Staphylococcus aureus Staphylococcus aureus MIC 128.0 ug.mL-1 10.1016/j.bmcl.2010.03.038
Staphylococcus aureus Staphylococcus aureus MIC 128.0 ug.mL-1 10.1016/j.bmcl.2013.03.057
Staphylococcus aureus Staphylococcus aureus MIC 128.0 ug.mL-1 10.1016/j.bmcl.2018.06.006
Staphylococcus aureus Staphylococcus aureus MIC 128.0 ug.mL-1 10.1128/aac.00455-10
Staphylococcus aureus Staphylococcus aureus MIC 250.0 ug.mL-1 10.1021/acs.jnatprod.0c01309
Staphylococcus aureus Staphylococcus aureus MIC 256.0 ug.mL-1 10.1016/j.bmcl.2007.03.107
Staphylococcus aureus Staphylococcus aureus MIC 256.0 ug.mL-1 10.1016/j.bmcl.2010.03.038
Staphylococcus aureus Staphylococcus aureus MIC 256.0 ug.mL-1 10.1016/j.bmcl.2012.12.070
Staphylococcus aureus Staphylococcus aureus MIC 256.0 ug.mL-1 10.1016/j.bmcl.2017.02.041
Staphylococcus aureus Staphylococcus aureus MIC 256.0 ug.mL-1 10.1016/j.bmcl.2018.06.039
Staphylococcus aureus Staphylococcus aureus MIC 256.0 ug.mL-1 10.1016/j.bmcl.2018.09.012
Staphylococcus aureus Staphylococcus aureus MIC 256.0 ug.mL-1 10.1016/j.bmcl.2019.126850
Staphylococcus aureus Staphylococcus aureus MIC 256.0 ug.mL-1 10.1016/j.bmcl.2021.128110
Staphylococcus aureus Staphylococcus aureus MIC 256.0 ug.mL-1 10.1016/j.bmcl.2021.128330
Staphylococcus aureus Staphylococcus aureus MIC 256.0 ug.mL-1 10.1016/j.ejmech.2010.05.008
Staphylococcus aureus Staphylococcus aureus MIC 256.0 ug.mL-1 10.1016/j.ejmech.2012.01.023
Staphylococcus aureus Staphylococcus aureus MIC 256.0 ug.mL-1 10.1016/j.ejmech.2012.10.054
Staphylococcus aureus Staphylococcus aureus MIC 256.0 ug.mL-1 10.1016/j.ejmech.2019.02.073
Staphylococcus aureus Staphylococcus aureus MIC 256.0 ug.mL-1 10.1016/j.ejmech.2019.03.037
Staphylococcus aureus Staphylococcus aureus MIC 256.0 ug.mL-1 10.1016/j.ejmech.2019.07.022
Staphylococcus aureus Staphylococcus aureus MIC 512.0 ug.mL-1 10.1016/j.bmcl.2022.128761
Staphylococcus aureus Staphylococcus aureus MIC 1024.0 ug.mL-1 10.1016/j.ejmech.2010.09.060
Staphylococcus aureus Staphylococcus aureus MIC 10000.0 nM 10.6019/CHEMBL4513141
Staphylococcus aureus Staphylococcus aureus MIC nan None 10.1128/aac.00203-09
Staphylococcus aureus Staphylococcus aureus MIC nan None 10.1128/aac.00455-10
Staphylococcus aureus Staphylococcus aureus MIC50 2.0 ug.mL-1 10.1128/aac.00666-06
Staphylococcus aureus Staphylococcus aureus MIC50 4.0 ug.mL-1 10.1128/aac.00666-06
Staphylococcus aureus Staphylococcus aureus MIC90 1.0 ug.mL-1 10.1128/aac.00567-09
Staphylococcus aureus Staphylococcus aureus MIC90 8.0 ug.mL-1 10.1128/aac.00666-06
Staphylococcus aureus Staphylococcus aureus MIC90 16.0 ug.mL-1 10.1128/aac.00666-06
Staphylococcus aureus Staphylococcus aureus Ratio 2.0 None 10.1016/j.bmc.2015.08.020
Staphylococcus aureus Staphylococcus aureus Ratio 2.0 None 10.1016/j.bmcl.2017.02.041
Staphylococcus aureus Staphylococcus aureus Ratio 8.0 None 10.1016/j.ejmech.2019.03.037
Staphylococcus aureus Staphylococcus aureus Ratio 32.0 None 10.1016/j.bmc.2020.115729
Staphylococcus aureus Staphylococcus aureus Ratio 32.0 None 10.1016/j.ejmech.2018.09.053
Staphylococcus aureus Staphylococcus aureus Ratio 512.0 None 10.1016/j.ejmech.2019.07.022
Staphylococcus aureus Staphylococcus aureus Ratio nan None 10.1016/j.bmc.2015.08.020
Staphylococcus aureus Staphylococcus aureus Ratio nan None 10.1016/j.bmc.2020.115729
Staphylococcus aureus Staphylococcus aureus Selectivity ratio 8.0 None 10.1016/j.ejmech.2019.02.073
Staphylococcus aureus Staphylococcus aureus T1/2 3.91 hr 10.1128/aac.00455-10
Staphylococcus epidermidis Staphylococcus epidermidis Activity -3.9 % 10.1128/aac.01565-09
Staphylococcus epidermidis Staphylococcus epidermidis Activity 32.2 % 10.1128/aac.01565-09
Staphylococcus epidermidis Staphylococcus epidermidis Activity 38.7 % 10.1128/aac.01565-09
Staphylococcus epidermidis Staphylococcus epidermidis Activity 46.3 % 10.1128/aac.01565-09
Staphylococcus epidermidis Staphylococcus epidermidis Activity 50.3 % 10.1128/aac.01565-09
Staphylococcus epidermidis Staphylococcus epidermidis Activity 50.6 % 10.1128/aac.01565-09
Staphylococcus epidermidis Staphylococcus epidermidis Activity 51.5 % 10.1128/aac.01565-09
Staphylococcus epidermidis Staphylococcus epidermidis Activity 54.6 % 10.1128/aac.01565-09
Staphylococcus epidermidis Staphylococcus epidermidis Activity 54.9 % 10.1128/aac.01565-09
Staphylococcus epidermidis Staphylococcus epidermidis Activity 62.3 % 10.1128/aac.01565-09
Staphylococcus epidermidis Staphylococcus epidermidis Activity 62.8 % 10.1128/aac.01565-09
Staphylococcus epidermidis Staphylococcus epidermidis Activity 71.8 % 10.1128/aac.01565-09
Staphylococcus epidermidis Staphylococcus epidermidis Activity 74.6 % 10.1128/aac.01538-07
Staphylococcus epidermidis Staphylococcus epidermidis Activity 77.4 % 10.1128/aac.01538-07
Staphylococcus epidermidis Staphylococcus epidermidis Activity 78.6 % 10.1128/aac.01565-09
Staphylococcus epidermidis Staphylococcus epidermidis Activity 79.2 % 10.1128/aac.01538-07
Staphylococcus epidermidis Staphylococcus epidermidis Activity 94.1 % 10.1128/aac.01538-07
Staphylococcus epidermidis Staphylococcus epidermidis Activity 96.0 % 10.1128/aac.01538-07
Staphylococcus epidermidis Staphylococcus epidermidis Activity 100.0 % 10.1128/aac.01538-07
Staphylococcus epidermidis Staphylococcus epidermidis Activity 112.8 % 10.1128/aac.01565-09
Staphylococcus epidermidis Staphylococcus epidermidis Activity 140.2 % 10.1128/aac.01565-09
Staphylococcus epidermidis Staphylococcus epidermidis Activity 146.4 % 10.1128/aac.01565-09
Staphylococcus epidermidis Staphylococcus epidermidis Activity 147.2 % 10.1128/aac.01565-09
Staphylococcus epidermidis Staphylococcus epidermidis Activity 155.6 % 10.1128/aac.01565-09
Staphylococcus epidermidis Staphylococcus epidermidis Activity 164.0 % 10.1128/aac.01565-09
Staphylococcus epidermidis Staphylococcus epidermidis Activity 201.5 % 10.1128/aac.01565-09
Staphylococcus epidermidis Staphylococcus epidermidis Activity 275.8 % 10.1128/aac.01565-09
Staphylococcus epidermidis Staphylococcus epidermidis Activity 292.0 % 10.1128/aac.01565-09
Staphylococcus epidermidis Staphylococcus epidermidis Activity nan None 10.1128/aac.01538-07
Staphylococcus epidermidis Staphylococcus epidermidis MIC 0.03 ug.mL-1 10.1016/S0960-894X(97)00078-4
Staphylococcus epidermidis Staphylococcus epidermidis MIC 0.06 ug.mL-1 10.1016/j.bmcl.2018.06.039
Staphylococcus epidermidis Staphylococcus epidermidis MIC 0.06 ug.mL-1 10.1016/j.ejmech.2013.08.023
Staphylococcus epidermidis Staphylococcus epidermidis MIC 0.12 ug.mL-1 10.1016/j.bmcl.2022.129115
Staphylococcus epidermidis Staphylococcus epidermidis MIC 0.12 ug.mL-1 10.1016/S0960-894X(97)00078-4
Staphylococcus epidermidis Staphylococcus epidermidis MIC 0.125 ug.mL-1 10.1016/j.bmcl.2007.03.107
Staphylococcus epidermidis Staphylococcus epidermidis MIC 0.125 ug.mL-1 10.1016/j.bmcl.2012.10.064
Staphylococcus epidermidis Staphylococcus epidermidis MIC 0.125 ug.mL-1 10.1016/j.bmcl.2018.06.039
Staphylococcus epidermidis Staphylococcus epidermidis MIC 0.125 ug.mL-1 10.1016/j.ejmech.2010.11.004
Staphylococcus epidermidis Staphylococcus epidermidis MIC 0.2 ug.mL-1 10.1016/j.bmcl.2006.05.104
Staphylococcus epidermidis Staphylococcus epidermidis MIC 0.2 ug.mL-1 10.1021/jm051157a
Staphylococcus epidermidis Staphylococcus epidermidis MIC 0.25 ug.mL-1 10.1016/j.bmcl.2012.10.064
Staphylococcus epidermidis Staphylococcus epidermidis MIC 0.25 ug.mL-1 10.1016/j.ejmech.2010.11.004
Staphylococcus epidermidis Staphylococcus epidermidis MIC 0.25 ug.mL-1 10.1016/j.ejmech.2016.10.065
Staphylococcus epidermidis Staphylococcus epidermidis MIC 0.25 ug.mL-1 10.1021/acs.jnatprod.2c00020
Staphylococcus epidermidis Staphylococcus epidermidis MIC 1.0 ug.mL-1 10.1016/j.bmcl.2013.09.083
Staphylococcus epidermidis Staphylococcus epidermidis MIC 4.0 ug.mL-1 10.1016/j.bmcl.2013.09.083
Staphylococcus epidermidis Staphylococcus epidermidis MIC 4.0 ug.mL-1 10.1016/j.ejmech.2013.08.023
Staphylococcus epidermidis Staphylococcus epidermidis MIC 8.0 ug.mL-1 10.1016/j.bmcl.2013.01.067
Staphylococcus epidermidis Staphylococcus epidermidis MIC 8.0 ug.mL-1 10.1016/j.bmcl.2013.09.083
Staphylococcus epidermidis Staphylococcus epidermidis MIC 8.0 ug.mL-1 10.1016/j.ejmech.2010.11.004
Staphylococcus epidermidis Staphylococcus epidermidis MIC 16.0 ug.mL-1 10.1016/j.bmcl.2010.07.072
Staphylococcus epidermidis Staphylococcus epidermidis MIC 16.0 ug.mL-1 10.1128/aac.01565-09
Staphylococcus epidermidis Staphylococcus epidermidis MIC 32.0 ug.mL-1 10.1016/j.bmcl.2012.10.064
Staphylococcus epidermidis Staphylococcus epidermidis MIC 32.0 ug.mL-1 10.1016/j.bmcl.2013.09.083
Staphylococcus epidermidis Staphylococcus epidermidis MIC 32.0 ug.mL-1 10.1016/j.ejmech.2010.11.004
Staphylococcus epidermidis Staphylococcus epidermidis MIC 40.0 ug.mL-1 10.1021/jm980240d
Staphylococcus epidermidis Staphylococcus epidermidis MIC 64.0 ug.mL-1 10.1016/j.bmcl.2013.03.057
Staphylococcus epidermidis Staphylococcus epidermidis MIC 64.0 ug.mL-1 10.1016/j.bmcl.2018.06.039
Staphylococcus epidermidis Staphylococcus epidermidis MIC 64.0 ug.mL-1 10.1016/j.bmcl.2022.129115
Staphylococcus epidermidis Staphylococcus epidermidis MIC 64.0 ug.mL-1 10.1016/j.ejmech.2013.08.023
Staphylococcus epidermidis Staphylococcus epidermidis MIC 128.0 ug.mL-1 10.1128/aac.01565-09
Staphylococcus epidermidis Staphylococcus epidermidis MIC 256.0 ug.mL-1 10.1016/j.bmcl.2007.03.107
Staphylococcus epidermidis Staphylococcus epidermidis MIC 256.0 ug.mL-1 10.1016/j.bmcl.2012.12.070
Staphylococcus epidermidis Staphylococcus epidermidis MIC 256.0 ug.mL-1 10.1016/j.bmcl.2018.06.039
Staphylococcus epidermidis Staphylococcus epidermidis MIC 256.0 ug.mL-1 10.1016/j.ejmech.2012.01.023
Staphylococcus epidermidis Staphylococcus epidermidis MIC 256.0 ug.mL-1 10.1016/j.ejmech.2012.10.054
Staphylococcus epidermidis Staphylococcus epidermidis MIC 256.0 ug.mL-1 10.1016/j.ejmech.2019.03.037
Staphylococcus haemolyticus Staphylococcus haemolyticus MIC 256.0 ug.mL-1 10.1016/j.ejmech.2012.01.023
Staphylococcus haemolyticus Staphylococcus haemolyticus MIC 256.0 ug.mL-1 10.1016/j.ejmech.2012.10.054
Staphylococcus hominis Staphylococcus hominis MIC 256.0 ug.mL-1 10.1016/j.ejmech.2012.01.023
Staphylococcus hominis Staphylococcus hominis MIC 256.0 ug.mL-1 10.1016/j.ejmech.2012.10.054
Staphylococcus saprophyticus Staphylococcus saprophyticus MIC 0.125 ug.mL-1 10.1128/aac.01150-07
Staphylococcus saprophyticus Staphylococcus saprophyticus MIC 16.0 ug.mL-1 10.1128/aac.01150-07
Staphylococcus saprophyticus Staphylococcus saprophyticus MIC 32.0 ug.mL-1 10.1128/aac.01150-07
Staphylococcus saprophyticus Staphylococcus saprophyticus MIC50 0.06 ug.mL-1 10.1128/aac.01150-07
Staphylococcus saprophyticus Staphylococcus saprophyticus MIC90 1.0 ug.mL-1 10.1128/aac.01150-07
Staphylococcus sp. Staphylococcus sp. MIC50 1.2 ug.mL-1 10.1021/jm980240d
Staphylococcus sp. Staphylococcus sp. MIC50 40.0 ug.mL-1 10.1021/jm980240d
Staphylococcus sp. Staphylococcus sp. MIC50/MIC90 nan None 10.1016/s0960-894x(99)00534-x
Staphylococcus sp. Staphylococcus sp. MIC90 40.0 ug.mL-1 10.1021/jm980240d
Streptococcus Streptococcus EC50 60.0 nM None
Streptococcus agalactiae Streptococcus agalactiae MIC 0.02 ug.mL-1 10.1016/S0960-894X(97)00078-4
Streptococcus agalactiae Streptococcus agalactiae MIC 0.031 ug.mL-1 10.1128/aac.01716-08
Streptococcus agalactiae Streptococcus agalactiae MIC50 0.125 ug.mL-1 10.1128/aac.01716-08
Streptococcus agalactiae Streptococcus agalactiae MIC90 64.0 ug.mL-1 10.1128/aac.01716-08
Streptococcus dysgalactiae Streptococcus dysgalactiae MIC 8.0 ug.mL-1 10.1016/j.ejmech.2012.01.023
Streptococcus dysgalactiae Streptococcus dysgalactiae MIC 8.0 ug.mL-1 10.1016/j.ejmech.2012.10.054
Streptococcus dysgalactiae Streptococcus dysgalactiae MIC 16.0 ug.mL-1 10.1016/j.bmcl.2012.12.070
Streptococcus equinus Streptococcus equinus MIC 0.01 ug.mL-1 10.1016/S0960-894X(97)00078-4
Streptococcus intermedius Streptococcus intermedius MIC 0.004 ug.mL-1 10.1021/jm8000136
Streptococcus mitis Streptococcus mitis MIC90 0.25 ug.mL-1 10.1016/j.bmc.2016.10.019
Streptococcus pneumoniae Streptococcus pneumoniae Activity 11.8 % 10.1128/aac.01388-08
Streptococcus pneumoniae Streptococcus pneumoniae Activity 13.2 % 10.1128/aac.01538-07
Streptococcus pneumoniae Streptococcus pneumoniae Activity 15.9 % 10.1128/aac.01538-07
Streptococcus pneumoniae Streptococcus pneumoniae Activity 16.4 % 10.1128/aac.01538-07
Streptococcus pneumoniae Streptococcus pneumoniae Activity 16.7 % 10.1128/aac.01538-07
Streptococcus pneumoniae Streptococcus pneumoniae Activity 20.9 % 10.1128/aac.01548-09
Streptococcus pneumoniae Streptococcus pneumoniae Activity 23.4 % 10.1128/aac.00107-07
Streptococcus pneumoniae Streptococcus pneumoniae Activity 72.8 % 10.1128/aac.00107-07
Streptococcus pneumoniae Streptococcus pneumoniae Activity 78.2 % 10.1128/aac.01548-09
Streptococcus pneumoniae Streptococcus pneumoniae Activity nan None 10.1016/j.bmcl.2009.06.023
Streptococcus pneumoniae Streptococcus pneumoniae Activity nan None 10.1128/aac.01459-06
Streptococcus pneumoniae Streptococcus pneumoniae ED50 2.1 mg.kg-1 10.1128/aac.00026-09
Streptococcus pneumoniae Streptococcus pneumoniae ED50 27.2 mg.kg-1 10.1016/j.ejmech.2016.09.022
Streptococcus pneumoniae Streptococcus pneumoniae ED50 27.2 mg kg-1 day-1 10.1021/jm970548p
Streptococcus pneumoniae Streptococcus pneumoniae ED50 60.0 mg.kg-1 10.1128/aac.00026-09
Streptococcus pneumoniae Streptococcus pneumoniae IC50 90.0 nM 10.1021/jm0102349
Streptococcus pneumoniae Streptococcus pneumoniae IC50 500000.0 nM 10.1021/jm0102349
Streptococcus pneumoniae Streptococcus pneumoniae MBC 0.062 ug ml-1 10.1016/j.bmcl.2017.02.041
Streptococcus pneumoniae Streptococcus pneumoniae MBC 0.125 ug ml-1 10.1016/j.ejmech.2019.03.037
Streptococcus pneumoniae Streptococcus pneumoniae MBC 0.25 ug ml-1 10.1016/j.ejmech.2019.02.073
Streptococcus pneumoniae Streptococcus pneumoniae MBC 8.0 ug ml-1 10.1016/j.bmcl.2017.02.041
Streptococcus pneumoniae Streptococcus pneumoniae MBC 8.0 ug ml-1 10.1016/j.ejmech.2019.03.037
Streptococcus pneumoniae Streptococcus pneumoniae MBC 32.0 ug ml-1 10.1016/j.ejmech.2019.02.073
Streptococcus pneumoniae Streptococcus pneumoniae MBC 128.0 ug ml-1 10.1016/j.ejmech.2019.07.022
Streptococcus pneumoniae Streptococcus pneumoniae MBC 256.0 ug ml-1 10.1016/j.bmcl.2019.126850
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.004 ug.mL-1 10.1021/jm970547x
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.004 ug.mL-1 10.1128/aac.00827-07
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.004 ug.mL-1 10.1128/aac.01150-06
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.008 ug.mL-1 10.1128/aac.00827-07
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.008 ug.mL-1 10.1128/aac.01123-09
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.015 ug.mL-1 10.1016/j.bmc.2017.02.041
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.015 ug.mL-1 10.1128/aac.00026-09
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.016 ug.mL-1 10.1128/aac.00827-07
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.016 ug.mL-1 10.1128/aac.01123-09
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.016 ug.mL-1 10.1128/aac.01150-06
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.016 ug.mL-1 10.1128/aac.01531-08
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.025 ug.mL-1 10.1016/j.bmc.2008.01.027
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.025 ug.mL-1 10.1021/jm020568d
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.03 ug.mL-1 10.1016/j.bmc.2010.02.017
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.03 ug.mL-1 10.1016/j.bmc.2012.08.007
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.03 ug.mL-1 10.1016/j.bmcl.2009.01.092
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.03 ug.mL-1 10.1016/j.bmcl.2010.04.051
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.03 ug.mL-1 10.1016/j.bmcl.2012.06.092
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.03 ug.mL-1 10.1016/j.bmcl.2022.128761
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.03 ug.mL-1 10.1016/j.ejmech.2009.11.032
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.03 ug.mL-1 10.1016/j.ejmech.2010.11.035
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.03 ug.mL-1 10.1016/j.ejmech.2012.11.028
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.03 ug.mL-1 10.1021/jm0102349
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.03 ug.mL-1 10.1021/jm970548p
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.03 ug.mL-1 10.1021/ml100252s
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.03 ug.mL-1 10.1128/aac.00026-09
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.03 ug.mL-1 10.1128/aac.00827-07
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.03 ug.mL-1 10.1128/aac.01123-09
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.03 ug.mL-1 10.1128/aac.01459-06
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.03 ug.mL-1 10.1128/aac.01531-08
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.031 ug.mL-1 10.1016/j.bmcl.2017.02.041
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.031 ug.mL-1 10.1016/j.bmcl.2018.06.039
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.031 ug.mL-1 10.1016/j.ejmech.2010.11.004
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.032 ug.mL-1 10.1016/j.bmcl.2010.03.038
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.032 ug.mL-1 10.1016/j.bmcl.2012.12.070
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.032 ug.mL-1 10.1016/j.ejmech.2010.05.008
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.032 ug.mL-1 10.1016/j.ejmech.2012.01.023
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.032 ug.mL-1 10.1016/j.ejmech.2012.10.054
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.04 ug.mL-1 10.1016/s0960-894x(00)00392-9
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.04 ug.mL-1 10.1016/s0960-894x(99)00534-x
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.04 ug.mL-1 10.1021/jm980240d
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.05 ug.mL-1 10.1016/j.bmcl.2006.05.104
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.05 ug.mL-1 10.1021/jm015566s
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.05 ug.mL-1 10.1021/jm020568d
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.05 ug.mL-1 10.1021/jm051157a
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.06 ug.mL-1 10.1016/j.bmcl.2007.02.019
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.06 ug.mL-1 10.1016/j.ejmech.2019.03.037
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.06 ug.mL-1 10.1016/s0960-894x(00)00106-2
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.06 ug.mL-1 10.1021/jm900729s
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.06 ug.mL-1 10.1128/aac.01123-09
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.06 ug.mL-1 10.1128/aac.01153-06
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.062 ug.mL-1 10.1016/j.bmc.2015.08.020
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.062 ug.mL-1 10.1016/j.bmcl.2012.10.064
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.062 ug.mL-1 10.1016/j.ejmech.2010.11.004
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.062 ug.mL-1 10.1016/j.ejmech.2019.02.073
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.12 ug.mL-1 10.1016/j.bmcl.2022.129115
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.12 ug.mL-1 10.1016/j.ejmech.2011.04.004
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.125 ug.mL-1 10.1016/j.bmc.2010.06.048
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.125 ug.mL-1 10.1016/j.bmc.2011.07.010
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.125 ug.mL-1 10.1016/j.bmcl.2011.10.101
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.125 ug.mL-1 10.1016/j.bmcl.2012.03.076
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.125 ug.mL-1 10.1016/j.bmcl.2012.10.064
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.125 ug.mL-1 10.1016/j.bmcl.2013.01.067
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.125 ug.mL-1 10.1016/j.bmcl.2017.06.044
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.125 ug.mL-1 10.1016/j.ejmech.2010.09.060
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.125 ug.mL-1 10.1021/acs.jnatprod.2c00020
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.125 ug.mL-1 10.1128/aac.01123-09
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.25 ug.mL-1 10.1016/j.bmcl.2007.03.107
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.25 ug.mL-1 10.1016/j.bmcl.2011.10.101
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.25 ug.mL-1 10.1016/j.ejmech.2010.05.009
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.25 ug.mL-1 10.1128/aac.00827-07
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.25 ug.mL-1 10.1128/aac.01123-09
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.25 ug.mL-1 10.1128/aac.01150-06
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.5 ug.mL-1 10.1016/j.bmcl.2011.10.101
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.5 ug.mL-1 10.1128/aac.00827-07
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.5 ug.mL-1 10.1128/aac.01123-09
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.5 ug.mL-1 10.1128/aac.01150-06
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.78 ug.mL-1 10.1016/j.bmc.2008.01.027
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.78 ug.mL-1 10.1021/jm020568d
Streptococcus pneumoniae Streptococcus pneumoniae MIC 1.0 ug.mL-1 10.1016/j.bmc.2010.02.017
Streptococcus pneumoniae Streptococcus pneumoniae MIC 1.0 ug.mL-1 10.1016/j.bmcl.2013.09.083
Streptococcus pneumoniae Streptococcus pneumoniae MIC 1.0 ug.mL-1 10.1016/j.ejmech.2012.01.023
Streptococcus pneumoniae Streptococcus pneumoniae MIC 1.0 ug.mL-1 10.1016/j.ejmech.2012.10.054
Streptococcus pneumoniae Streptococcus pneumoniae MIC 1.0 ug.mL-1 10.1128/aac.00827-07
Streptococcus pneumoniae Streptococcus pneumoniae MIC 1.0 ug.mL-1 10.1128/aac.01123-09
Streptococcus pneumoniae Streptococcus pneumoniae MIC 1.0 ug.mL-1 10.1128/aac.01531-08
Streptococcus pneumoniae Streptococcus pneumoniae MIC 1.56 ug.mL-1 10.1021/jm015566s
Streptococcus pneumoniae Streptococcus pneumoniae MIC 2.0 ug.mL-1 10.1016/j.bmc.2015.08.020
Streptococcus pneumoniae Streptococcus pneumoniae MIC 2.0 ug.mL-1 10.1016/j.bmc.2017.02.041
Streptococcus pneumoniae Streptococcus pneumoniae MIC 2.0 ug.mL-1 10.1016/j.bmcl.2012.06.092
Streptococcus pneumoniae Streptococcus pneumoniae MIC 2.0 ug.mL-1 10.1016/j.bmcl.2013.09.083
Streptococcus pneumoniae Streptococcus pneumoniae MIC 2.0 ug.mL-1 10.1016/j.bmcl.2018.06.006
Streptococcus pneumoniae Streptococcus pneumoniae MIC 2.0 ug.mL-1 10.1016/j.bmcl.2018.09.012
Streptococcus pneumoniae Streptococcus pneumoniae MIC 2.0 ug.mL-1 10.1016/j.ejmech.2010.05.009
Streptococcus pneumoniae Streptococcus pneumoniae MIC 2.0 ug.mL-1 10.1016/j.ejmech.2010.11.004
Streptococcus pneumoniae Streptococcus pneumoniae MIC 2.0 ug.mL-1 10.1016/j.ejmech.2016.10.065
Streptococcus pneumoniae Streptococcus pneumoniae MIC 2.0 ug.mL-1 10.1128/aac.00827-07
Streptococcus pneumoniae Streptococcus pneumoniae MIC 2.0 ug.mL-1 10.1128/aac.01123-09
Streptococcus pneumoniae Streptococcus pneumoniae MIC 2.0 ug.mL-1 10.1128/aac.01150-06
Streptococcus pneumoniae Streptococcus pneumoniae MIC 2.0 ug.mL-1 10.1128/aac.01459-06
Streptococcus pneumoniae Streptococcus pneumoniae MIC 2.0 ug.mL-1 10.1128/aac.01531-08
Streptococcus pneumoniae Streptococcus pneumoniae MIC 3.13 ug.mL-1 10.1016/j.bmcl.2006.05.104
Streptococcus pneumoniae Streptococcus pneumoniae MIC 3.13 ug.mL-1 10.1021/jm051157a
Streptococcus pneumoniae Streptococcus pneumoniae MIC 4.0 ug.mL-1 10.1016/j.bmc.2010.06.048
Streptococcus pneumoniae Streptococcus pneumoniae MIC 4.0 ug.mL-1 10.1016/j.bmc.2010.06.049
Streptococcus pneumoniae Streptococcus pneumoniae MIC 4.0 ug.mL-1 10.1016/j.bmc.2011.07.010
Streptococcus pneumoniae Streptococcus pneumoniae MIC 4.0 ug.mL-1 10.1016/j.bmcl.2009.01.092
Streptococcus pneumoniae Streptococcus pneumoniae MIC 4.0 ug.mL-1 10.1016/j.bmcl.2010.04.051
Streptococcus pneumoniae Streptococcus pneumoniae MIC 4.0 ug.mL-1 10.1016/j.bmcl.2011.10.101
Streptococcus pneumoniae Streptococcus pneumoniae MIC 4.0 ug.mL-1 10.1016/j.bmcl.2017.02.041
Streptococcus pneumoniae Streptococcus pneumoniae MIC 4.0 ug.mL-1 10.1016/j.bmcl.2017.06.044
Streptococcus pneumoniae Streptococcus pneumoniae MIC 4.0 ug.mL-1 10.1016/j.bmcl.2017.07.017
Streptococcus pneumoniae Streptococcus pneumoniae MIC 4.0 ug.mL-1 10.1016/j.ejmech.2009.11.032
Streptococcus pneumoniae Streptococcus pneumoniae MIC 4.0 ug.mL-1 10.1016/j.ejmech.2010.05.008
Streptococcus pneumoniae Streptococcus pneumoniae MIC 4.0 ug.mL-1 10.1016/j.ejmech.2010.11.035
Streptococcus pneumoniae Streptococcus pneumoniae MIC 4.0 ug.mL-1 10.1016/j.ejmech.2011.04.004
Streptococcus pneumoniae Streptococcus pneumoniae MIC 4.0 ug.mL-1 10.1016/j.ejmech.2012.01.023
Streptococcus pneumoniae Streptococcus pneumoniae MIC 4.0 ug.mL-1 10.1016/j.ejmech.2012.10.054
Streptococcus pneumoniae Streptococcus pneumoniae MIC 4.0 ug.mL-1 10.1016/j.ejmech.2012.11.028
Streptococcus pneumoniae Streptococcus pneumoniae MIC 4.0 ug.mL-1 10.1016/j.ejmech.2019.02.073
Streptococcus pneumoniae Streptococcus pneumoniae MIC 4.0 ug.mL-1 10.1016/j.ejmech.2019.03.037
Streptococcus pneumoniae Streptococcus pneumoniae MIC 4.0 ug.mL-1 10.1128/aac.00827-07
Streptococcus pneumoniae Streptococcus pneumoniae MIC 4.0 ug.mL-1 10.1128/aac.01123-09
Streptococcus pneumoniae Streptococcus pneumoniae MIC 4.0 ug.mL-1 10.1128/aac.01150-06
Streptococcus pneumoniae Streptococcus pneumoniae MIC 6.25 ug.mL-1 10.1016/j.bmcl.2006.05.104
Streptococcus pneumoniae Streptococcus pneumoniae MIC 6.25 ug.mL-1 10.1021/jm051157a
Streptococcus pneumoniae Streptococcus pneumoniae MIC 8.0 ug.mL-1 10.1016/j.bmc.2017.02.041
Streptococcus pneumoniae Streptococcus pneumoniae MIC 8.0 ug.mL-1 10.1016/j.bmcl.2007.02.019
Streptococcus pneumoniae Streptococcus pneumoniae MIC 8.0 ug.mL-1 10.1016/j.bmcl.2022.128761
Streptococcus pneumoniae Streptococcus pneumoniae MIC 8.0 ug.mL-1 10.1016/j.ejmech.2020.112222
Streptococcus pneumoniae Streptococcus pneumoniae MIC 8.0 ug.mL-1 10.1128/aac.00827-07
Streptococcus pneumoniae Streptococcus pneumoniae MIC 8.0 ug.mL-1 10.1128/aac.01123-09
Streptococcus pneumoniae Streptococcus pneumoniae MIC 8.0 ug.mL-1 10.1128/aac.01150-06
Streptococcus pneumoniae Streptococcus pneumoniae MIC 8.0 ug.mL-1 10.1128/aac.01531-08
Streptococcus pneumoniae Streptococcus pneumoniae MIC 16.0 ug.mL-1 10.1016/j.bmc.2010.06.049
Streptococcus pneumoniae Streptococcus pneumoniae MIC 16.0 ug.mL-1 10.1016/j.bmc.2017.02.041
Streptococcus pneumoniae Streptococcus pneumoniae MIC 16.0 ug.mL-1 10.1016/j.bmcl.2010.07.072
Streptococcus pneumoniae Streptococcus pneumoniae MIC 16.0 ug.mL-1 10.1016/j.ejmech.2010.05.008
Streptococcus pneumoniae Streptococcus pneumoniae MIC 16.0 ug.mL-1 10.1016/j.ejmech.2010.09.060
Streptococcus pneumoniae Streptococcus pneumoniae MIC 16.0 ug.mL-1 10.1016/s0960-894x(00)00106-2
Streptococcus pneumoniae Streptococcus pneumoniae MIC 16.0 ug.mL-1 10.1021/jm900729s
Streptococcus pneumoniae Streptococcus pneumoniae MIC 16.0 ug.mL-1 10.1128/aac.00827-07
Streptococcus pneumoniae Streptococcus pneumoniae MIC 16.0 ug.mL-1 10.1128/aac.01123-09
Streptococcus pneumoniae Streptococcus pneumoniae MIC 16.0 ug.mL-1 10.1128/aac.01150-06
Streptococcus pneumoniae Streptococcus pneumoniae MIC 16.0 ug.mL-1 10.1128/aac.01531-08
Streptococcus pneumoniae Streptococcus pneumoniae MIC 24.0 ug.mL-1 10.1128/aac.01153-06
Streptococcus pneumoniae Streptococcus pneumoniae MIC 32.0 ug.mL-1 10.1016/j.bmcl.2007.03.107
Streptococcus pneumoniae Streptococcus pneumoniae MIC 32.0 ug.mL-1 10.1016/j.bmcl.2012.10.064
Streptococcus pneumoniae Streptococcus pneumoniae MIC 32.0 ug.mL-1 10.1016/j.bmcl.2013.09.083
Streptococcus pneumoniae Streptococcus pneumoniae MIC 32.0 ug.mL-1 10.1016/j.bmcl.2022.129115
Streptococcus pneumoniae Streptococcus pneumoniae MIC 32.0 ug.mL-1 10.1016/j.ejmech.2010.11.004
Streptococcus pneumoniae Streptococcus pneumoniae MIC 32.0 ug.mL-1 10.1016/j.ejmech.2019.02.073
Streptococcus pneumoniae Streptococcus pneumoniae MIC 32.0 ug.mL-1 10.1128/aac.00026-09
Streptococcus pneumoniae Streptococcus pneumoniae MIC 32.0 ug.mL-1 10.1128/aac.00827-07
Streptococcus pneumoniae Streptococcus pneumoniae MIC 32.0 ug.mL-1 10.1128/aac.01123-09
Streptococcus pneumoniae Streptococcus pneumoniae MIC 32.0 ug.mL-1 10.1128/aac.01150-06
Streptococcus pneumoniae Streptococcus pneumoniae MIC 32.0 ug.mL-1 10.1128/aac.01531-08
Streptococcus pneumoniae Streptococcus pneumoniae MIC 40.0 ug.mL-1 10.1016/s0960-894x(00)00392-9
Streptococcus pneumoniae Streptococcus pneumoniae MIC 40.0 ug.mL-1 10.1016/s0960-894x(99)00534-x
Streptococcus pneumoniae Streptococcus pneumoniae MIC 40.0 ug.mL-1 10.1021/jm980240d
Streptococcus pneumoniae Streptococcus pneumoniae MIC 50.0 ug.mL-1 10.1016/j.bmcl.2006.05.104
Streptococcus pneumoniae Streptococcus pneumoniae MIC 50.0 ug.mL-1 10.1021/jm051157a
Streptococcus pneumoniae Streptococcus pneumoniae MIC 64.0 ug.mL-1 10.1016/j.bmc.2010.06.048
Streptococcus pneumoniae Streptococcus pneumoniae MIC 64.0 ug.mL-1 10.1016/j.bmc.2010.06.049
Streptococcus pneumoniae Streptococcus pneumoniae MIC 64.0 ug.mL-1 10.1016/j.bmc.2011.07.010
Streptococcus pneumoniae Streptococcus pneumoniae MIC 64.0 ug.mL-1 10.1016/j.bmc.2015.08.020
Streptococcus pneumoniae Streptococcus pneumoniae MIC 64.0 ug.mL-1 10.1016/j.bmcl.2009.01.092
Streptococcus pneumoniae Streptococcus pneumoniae MIC 64.0 ug.mL-1 10.1016/j.bmcl.2010.04.051
Streptococcus pneumoniae Streptococcus pneumoniae MIC 64.0 ug.mL-1 10.1016/j.bmcl.2018.06.039
Streptococcus pneumoniae Streptococcus pneumoniae MIC 64.0 ug.mL-1 10.1016/j.ejmech.2009.11.032
Streptococcus pneumoniae Streptococcus pneumoniae MIC 64.0 ug.mL-1 10.1016/j.ejmech.2010.11.035
Streptococcus pneumoniae Streptococcus pneumoniae MIC 64.0 ug.mL-1 10.1016/j.ejmech.2012.11.028
Streptococcus pneumoniae Streptococcus pneumoniae MIC 64.0 ug.mL-1 10.1021/jm900729s
Streptococcus pneumoniae Streptococcus pneumoniae MIC 64.0 ug.mL-1 10.1128/aac.00827-07
Streptococcus pneumoniae Streptococcus pneumoniae MIC 64.0 ug.mL-1 10.1128/aac.01123-09
Streptococcus pneumoniae Streptococcus pneumoniae MIC 64.0 ug.mL-1 10.1128/aac.01150-06
Streptococcus pneumoniae Streptococcus pneumoniae MIC 64.0 ug.mL-1 10.1128/aac.01531-08
Streptococcus pneumoniae Streptococcus pneumoniae MIC 100.0 ug.mL-1 10.1016/j.bmc.2008.01.027
Streptococcus pneumoniae Streptococcus pneumoniae MIC 100.0 ug.mL-1 10.1021/jm015566s
Streptococcus pneumoniae Streptococcus pneumoniae MIC 100.0 ug.mL-1 10.1021/jm020568d
Streptococcus pneumoniae Streptococcus pneumoniae MIC 128.0 ug.mL-1 10.1016/j.bmc.2010.02.017
Streptococcus pneumoniae Streptococcus pneumoniae MIC 128.0 ug.mL-1 10.1016/j.bmc.2012.08.007
Streptococcus pneumoniae Streptococcus pneumoniae MIC 128.0 ug.mL-1 10.1016/j.bmcl.2007.02.019
Streptococcus pneumoniae Streptococcus pneumoniae MIC 128.0 ug.mL-1 10.1016/j.bmcl.2007.03.107
Streptococcus pneumoniae Streptococcus pneumoniae MIC 128.0 ug.mL-1 10.1016/j.bmcl.2009.01.092
Streptococcus pneumoniae Streptococcus pneumoniae MIC 128.0 ug.mL-1 10.1016/j.bmcl.2010.03.038
Streptococcus pneumoniae Streptococcus pneumoniae MIC 128.0 ug.mL-1 10.1016/j.bmcl.2010.04.051
Streptococcus pneumoniae Streptococcus pneumoniae MIC 128.0 ug.mL-1 10.1016/j.bmcl.2012.06.092
Streptococcus pneumoniae Streptococcus pneumoniae MIC 128.0 ug.mL-1 10.1016/j.bmcl.2017.06.044
Streptococcus pneumoniae Streptococcus pneumoniae MIC 128.0 ug.mL-1 10.1016/j.bmcl.2017.07.017
Streptococcus pneumoniae Streptococcus pneumoniae MIC 128.0 ug.mL-1 10.1016/j.bmcl.2018.06.006
Streptococcus pneumoniae Streptococcus pneumoniae MIC 128.0 ug.mL-1 10.1016/j.bmcl.2018.09.012
Streptococcus pneumoniae Streptococcus pneumoniae MIC 128.0 ug.mL-1 10.1016/j.bmcl.2019.126850
Streptococcus pneumoniae Streptococcus pneumoniae MIC 128.0 ug.mL-1 10.1016/j.ejmech.2009.11.032
Streptococcus pneumoniae Streptococcus pneumoniae MIC 128.0 ug.mL-1 10.1016/j.ejmech.2010.05.008
Streptococcus pneumoniae Streptococcus pneumoniae MIC 128.0 ug.mL-1 10.1016/j.ejmech.2010.11.035
Streptococcus pneumoniae Streptococcus pneumoniae MIC 128.0 ug.mL-1 10.1016/j.ejmech.2011.04.004
Streptococcus pneumoniae Streptococcus pneumoniae MIC 128.0 ug.mL-1 10.1016/j.ejmech.2012.11.028
Streptococcus pneumoniae Streptococcus pneumoniae MIC 128.0 ug.mL-1 10.1016/j.ejmech.2016.10.065
Streptococcus pneumoniae Streptococcus pneumoniae MIC 128.0 ug.mL-1 10.1016/j.ejmech.2019.07.022
Streptococcus pneumoniae Streptococcus pneumoniae MIC 128.0 ug.mL-1 10.1016/s0960-894x(00)00106-2
Streptococcus pneumoniae Streptococcus pneumoniae MIC 128.0 ug.mL-1 10.1021/ml100252s
Streptococcus pneumoniae Streptococcus pneumoniae MIC 128.0 ug.mL-1 10.1128/aac.01150-06
Streptococcus pneumoniae Streptococcus pneumoniae MIC 256.0 ug.mL-1 10.1016/j.bmcl.2007.03.107
Streptococcus pneumoniae Streptococcus pneumoniae MIC 256.0 ug.mL-1 10.1016/j.bmcl.2012.12.070
Streptococcus pneumoniae Streptococcus pneumoniae MIC 256.0 ug.mL-1 10.1016/j.bmcl.2019.126850
Streptococcus pneumoniae Streptococcus pneumoniae MIC 256.0 ug.mL-1 10.1016/j.bmcl.2021.128110
Streptococcus pneumoniae Streptococcus pneumoniae MIC 256.0 ug.mL-1 10.1016/j.ejmech.2012.01.023
Streptococcus pneumoniae Streptococcus pneumoniae MIC 256.0 ug.mL-1 10.1016/j.ejmech.2012.10.054
Streptococcus pneumoniae Streptococcus pneumoniae MIC 256.0 ug.mL-1 10.1016/j.ejmech.2016.10.065
Streptococcus pneumoniae Streptococcus pneumoniae MIC 256.0 ug.mL-1 10.1016/j.ejmech.2019.07.022
Streptococcus pneumoniae Streptococcus pneumoniae MIC 256.0 ug.mL-1 10.1016/j.ejmech.2020.112222
Streptococcus pneumoniae Streptococcus pneumoniae MIC 256.0 ug.mL-1 10.1128/aac.01074-07
Streptococcus pneumoniae Streptococcus pneumoniae MIC 256.0 ug.mL-1 10.1128/aac.01153-06
Streptococcus pneumoniae Streptococcus pneumoniae MIC 256.0 ug.mL-1 10.1128/aac.01459-06
Streptococcus pneumoniae Streptococcus pneumoniae MIC 512.0 ug.mL-1 10.1016/j.bmcl.2022.128761
Streptococcus pneumoniae Streptococcus pneumoniae MIC50 0.015 ug.mL-1 10.1128/aac.01548-09
Streptococcus pneumoniae Streptococcus pneumoniae MIC50 0.03 ug.mL-1 10.1128/aac.01123-09
Streptococcus pneumoniae Streptococcus pneumoniae MIC50 0.06 ug.mL-1 10.1128/aac.01531-08
Streptococcus pneumoniae Streptococcus pneumoniae MIC50 0.5 ug.mL-1 10.1128/aac.01531-08
Streptococcus pneumoniae Streptococcus pneumoniae MIC50 1.0 ug.mL-1 10.1128/aac.01123-09
Streptococcus pneumoniae Streptococcus pneumoniae MIC50 1.0 ug.mL-1 10.1128/aac.01531-08
Streptococcus pneumoniae Streptococcus pneumoniae MIC50 2.0 ug.mL-1 10.1128/aac.01123-09
Streptococcus pneumoniae Streptococcus pneumoniae MIC50 16.0 ug.mL-1 10.1128/aac.01123-09
Streptococcus pneumoniae Streptococcus pneumoniae MIC50 32.0 ug.mL-1 10.1021/jm301650g
Streptococcus pneumoniae Streptococcus pneumoniae MIC50 64.0 ug.mL-1 10.1128/aac.00107-07
Streptococcus pneumoniae Streptococcus pneumoniae MIC50 64.0 ug.mL-1 10.1128/aac.01123-09
Streptococcus pneumoniae Streptococcus pneumoniae MIC50 64.0 ug.mL-1 10.1128/aac.01531-08
Streptococcus pneumoniae Streptococcus pneumoniae MIC50/MIC90 nan None 10.1016/s0960-894x(99)00534-x
Streptococcus pneumoniae Streptococcus pneumoniae MIC80 32.0 ug.mL-1 10.1021/jm301650g
Streptococcus pneumoniae Streptococcus pneumoniae MIC90 0.06 ug.mL-1 10.1128/aac.01123-09
Streptococcus pneumoniae Streptococcus pneumoniae MIC90 1.0 ug.mL-1 10.1128/aac.00567-09
Streptococcus pneumoniae Streptococcus pneumoniae MIC90 4.0 ug.mL-1 10.1128/aac.01123-09
Streptococcus pneumoniae Streptococcus pneumoniae MIC90 32.0 ug.mL-1 10.1021/jm301650g
Streptococcus pneumoniae Streptococcus pneumoniae MIC90 32.0 ug.mL-1 10.1128/aac.01123-09
Streptococcus pneumoniae Streptococcus pneumoniae MIC90 64.0 ug.mL-1 10.1128/aac.01123-09
Streptococcus pneumoniae Streptococcus pneumoniae MIC90 64.0 ug.mL-1 10.1128/aac.01531-08
Streptococcus pneumoniae Streptococcus pneumoniae MIC90 128.0 ug.mL-1 10.1128/aac.00107-07
Streptococcus pneumoniae Streptococcus pneumoniae MIC90 128.0 ug.mL-1 10.1128/aac.01548-09
Streptococcus pneumoniae Streptococcus pneumoniae MST 6.82 day 10.1128/aac.01459-06
Streptococcus pneumoniae Streptococcus pneumoniae MST 8.45 day 10.1128/aac.01459-06
Streptococcus pneumoniae Streptococcus pneumoniae PD50 100.0 mg kg-1 10.1021/jm900729s
Streptococcus pneumoniae Streptococcus pneumoniae Post Antibiotic Effe 3.8 hr 10.1128/aac.01150-06
Streptococcus pneumoniae Streptococcus pneumoniae Ratio 1.0 None 10.1016/j.ejmech.2019.07.022
Streptococcus pneumoniae Streptococcus pneumoniae Ratio 2.0 None 10.1016/j.bmcl.2017.02.041
Streptococcus pneumoniae Streptococcus pneumoniae Ratio 2.0 None 10.1016/j.ejmech.2019.03.037
Streptococcus pneumoniae Streptococcus pneumoniae Ratio 16.0 None 10.1016/j.bmcl.2019.126850
Streptococcus pneumoniae Streptococcus pneumoniae Selectivity ratio 4.0 None 10.1016/j.ejmech.2019.02.073
Streptococcus pneumoniae Streptococcus pneumoniae Selectivity ratio 8.0 None 10.1016/j.ejmech.2019.02.073
Streptococcus pyogenes Streptococcus pyogenes Activity 16.5 % 10.1128/aac.01548-09
Streptococcus pyogenes Streptococcus pyogenes Activity 80.9 % 10.1128/aac.01548-09
Streptococcus pyogenes Streptococcus pyogenes Activity nan None 10.1016/j.bmcl.2009.06.023
Streptococcus pyogenes Streptococcus pyogenes MBC 8.0 ug ml-1 10.1016/j.bmc.2015.08.020
Streptococcus pyogenes Streptococcus pyogenes MBC 8.0 ug ml-1 10.1016/j.bmcl.2017.02.041
Streptococcus pyogenes Streptococcus pyogenes MBC 8.0 ug ml-1 10.1016/j.ejmech.2019.03.037
Streptococcus pyogenes Streptococcus pyogenes MBC 32.0 ug ml-1 10.1016/j.bmc.2015.08.020
Streptococcus pyogenes Streptococcus pyogenes MBC 32.0 ug ml-1 10.1016/j.bmcl.2017.02.041
Streptococcus pyogenes Streptococcus pyogenes MBC 64.0 ug ml-1 10.1016/j.ejmech.2019.02.073
Streptococcus pyogenes Streptococcus pyogenes MBC50 8.0 mg/L 10.1128/aac.00666-06
Streptococcus pyogenes Streptococcus pyogenes MBC90 32.0 mg/L 10.1128/aac.00666-06
Streptococcus pyogenes Streptococcus pyogenes MIC 0.008 ug.mL-1 10.1016/j.bmcl.2012.12.070
Streptococcus pyogenes Streptococcus pyogenes MIC 0.008 ug.mL-1 10.1016/s0960-894x(00)00392-9
Streptococcus pyogenes Streptococcus pyogenes MIC 0.01 ug.mL-1 10.1016/S0960-894X(97)00078-4
Streptococcus pyogenes Streptococcus pyogenes MIC 0.016 ug.mL-1 10.1016/j.bmcl.2018.06.039
Streptococcus pyogenes Streptococcus pyogenes MIC 0.03 ug.mL-1 10.1016/j.bmc.2010.02.017
Streptococcus pyogenes Streptococcus pyogenes MIC 0.03 ug.mL-1 10.1016/j.bmcl.2017.06.044
Streptococcus pyogenes Streptococcus pyogenes MIC 0.03 ug.mL-1 10.1016/j.bmcl.2017.07.017
Streptococcus pyogenes Streptococcus pyogenes MIC 0.03 ug.mL-1 10.1016/j.bmcl.2018.06.006
Streptococcus pyogenes Streptococcus pyogenes MIC 0.03 ug.mL-1 10.1016/j.bmcl.2018.06.039
Streptococcus pyogenes Streptococcus pyogenes MIC 0.03 ug.mL-1 10.1016/j.bmcl.2018.09.012
Streptococcus pyogenes Streptococcus pyogenes MIC 0.03 ug.mL-1 10.1016/j.bmcl.2022.129115
Streptococcus pyogenes Streptococcus pyogenes MIC 0.03 ug.mL-1 10.1016/j.ejmech.2010.11.035
Streptococcus pyogenes Streptococcus pyogenes MIC 0.03 ug.mL-1 10.1016/j.ejmech.2012.11.028
Streptococcus pyogenes Streptococcus pyogenes MIC 0.03 ug.mL-1 10.1016/j.ejmech.2016.10.065
Streptococcus pyogenes Streptococcus pyogenes MIC 0.03 ug.mL-1 10.1016/j.ejmech.2019.07.022
Streptococcus pyogenes Streptococcus pyogenes MIC 0.03 ug.mL-1 10.1016/s0960-894x(00)00106-2
Streptococcus pyogenes Streptococcus pyogenes MIC 0.031 ug.mL-1 10.1016/j.bmcl.2012.10.064
Streptococcus pyogenes Streptococcus pyogenes MIC 0.031 ug.mL-1 10.1016/j.ejmech.2010.11.004
Streptococcus pyogenes Streptococcus pyogenes MIC 0.032 ug.mL-1 10.1016/j.ejmech.2012.01.023
Streptococcus pyogenes Streptococcus pyogenes MIC 0.032 ug.mL-1 10.1016/j.ejmech.2012.10.054
Streptococcus pyogenes Streptococcus pyogenes MIC 0.032 ug.mL-1 10.1016/j.ejmech.2019.03.037
Streptococcus pyogenes Streptococcus pyogenes MIC 0.05 ug.mL-1 10.1016/j.bmcl.2006.05.104
Streptococcus pyogenes Streptococcus pyogenes MIC 0.05 ug.mL-1 10.1021/jm051157a
Streptococcus pyogenes Streptococcus pyogenes MIC 0.06 ug.mL-1 10.1016/j.bmcl.2007.02.019
Streptococcus pyogenes Streptococcus pyogenes MIC 0.062 ug.mL-1 10.1016/j.bmcl.2007.03.107
Streptococcus pyogenes Streptococcus pyogenes MIC 0.08 ug.mL-1 10.1016/s0960-894x(99)00534-x
Streptococcus pyogenes Streptococcus pyogenes MIC 0.08 ug.mL-1 10.1021/jm980240d
Streptococcus pyogenes Streptococcus pyogenes MIC 0.12 ug.mL-1 10.1016/j.ejmech.2009.11.032
Streptococcus pyogenes Streptococcus pyogenes MIC 0.125 ug.mL-1 10.1016/j.bmc.2010.06.048
Streptococcus pyogenes Streptococcus pyogenes MIC 0.125 ug.mL-1 10.1016/j.bmc.2011.07.010
Streptococcus pyogenes Streptococcus pyogenes MIC 0.125 ug.mL-1 10.1016/j.bmcl.2007.03.107
Streptococcus pyogenes Streptococcus pyogenes MIC 0.125 ug.mL-1 10.1016/j.bmcl.2011.10.101
Streptococcus pyogenes Streptococcus pyogenes MIC 0.125 ug.mL-1 10.1016/j.bmcl.2012.03.076
Streptococcus pyogenes Streptococcus pyogenes MIC 0.2 ug.mL-1 10.1039/C0MD00251H
Streptococcus pyogenes Streptococcus pyogenes MIC 0.25 ug.mL-1 10.1016/j.bmcl.2013.01.067
Streptococcus pyogenes Streptococcus pyogenes MIC 0.3 ug.mL-1 10.1039/C0MD00251H
Streptococcus pyogenes Streptococcus pyogenes MIC 1.0 ug.mL-1 10.1016/j.bmc.2010.06.048
Streptococcus pyogenes Streptococcus pyogenes MIC 1.0 ug.mL-1 10.1016/j.bmc.2010.06.049
Streptococcus pyogenes Streptococcus pyogenes MIC 1.0 ug.mL-1 10.1016/j.bmc.2011.07.010
Streptococcus pyogenes Streptococcus pyogenes MIC 1.0 ug.mL-1 10.1016/j.bmcl.2013.09.083
Streptococcus pyogenes Streptococcus pyogenes MIC 1.0 ug.mL-1 10.1016/j.bmcl.2017.02.041
Streptococcus pyogenes Streptococcus pyogenes MIC 1.0 ug.mL-1 10.1016/j.ejmech.2019.03.037
Streptococcus pyogenes Streptococcus pyogenes MIC 1.0 ug.mL-1 10.1128/aac.01123-09
Streptococcus pyogenes Streptococcus pyogenes MIC 2.0 ug.mL-1 10.1016/j.bmcl.2007.02.019
Streptococcus pyogenes Streptococcus pyogenes MIC 2.0 ug.mL-1 10.1016/j.bmcl.2010.07.072
Streptococcus pyogenes Streptococcus pyogenes MIC 2.0 ug.mL-1 10.1016/j.ejmech.2010.11.004
Streptococcus pyogenes Streptococcus pyogenes MIC 2.0 ug.mL-1 10.1128/aac.01065-08
Streptococcus pyogenes Streptococcus pyogenes MIC 3.13 ug.mL-1 10.1016/j.bmc.2008.01.027
Streptococcus pyogenes Streptococcus pyogenes MIC 4.0 ug.mL-1 10.1016/j.bmc.2010.06.048
Streptococcus pyogenes Streptococcus pyogenes MIC 4.0 ug.mL-1 10.1016/j.bmc.2010.06.049
Streptococcus pyogenes Streptococcus pyogenes MIC 4.0 ug.mL-1 10.1016/j.bmc.2011.07.010
Streptococcus pyogenes Streptococcus pyogenes MIC 4.0 ug.mL-1 10.1016/j.bmc.2015.08.020
Streptococcus pyogenes Streptococcus pyogenes MIC 4.0 ug.mL-1 10.1016/j.bmcl.2013.09.083
Streptococcus pyogenes Streptococcus pyogenes MIC 4.0 ug.mL-1 10.1016/j.ejmech.2010.11.035
Streptococcus pyogenes Streptococcus pyogenes MIC 4.0 ug.mL-1 10.1016/j.ejmech.2012.11.028
Streptococcus pyogenes Streptococcus pyogenes MIC 4.0 ug.mL-1 10.1128/aac.01065-08
Streptococcus pyogenes Streptococcus pyogenes MIC 8.0 ug.mL-1 10.1016/j.bmc.2010.02.017
Streptococcus pyogenes Streptococcus pyogenes MIC 8.0 ug.mL-1 10.1016/j.ejmech.2019.02.073
Streptococcus pyogenes Streptococcus pyogenes MIC 8.0 ug.mL-1 10.1016/S0960-894X(97)00078-4
Streptococcus pyogenes Streptococcus pyogenes MIC 16.0 ug.mL-1 10.1016/j.bmc.2010.06.049
Streptococcus pyogenes Streptococcus pyogenes MIC 16.0 ug.mL-1 10.1016/j.bmc.2015.08.020
Streptococcus pyogenes Streptococcus pyogenes MIC 16.0 ug.mL-1 10.1016/j.bmcl.2017.02.041
Streptococcus pyogenes Streptococcus pyogenes MIC 32.0 ug.mL-1 10.1016/j.bmcl.2010.07.072
Streptococcus pyogenes Streptococcus pyogenes MIC 32.0 ug.mL-1 10.1016/j.bmcl.2012.10.064
Streptococcus pyogenes Streptococcus pyogenes MIC 32.0 ug.mL-1 10.1016/j.ejmech.2010.11.004
Streptococcus pyogenes Streptococcus pyogenes MIC 32.0 ug.mL-1 10.1016/s0960-894x(00)00106-2
Streptococcus pyogenes Streptococcus pyogenes MIC 64.0 ug.mL-1 10.1016/j.bmc.2010.06.048
Streptococcus pyogenes Streptococcus pyogenes MIC 64.0 ug.mL-1 10.1016/j.bmc.2011.07.010
Streptococcus pyogenes Streptococcus pyogenes MIC 64.0 ug.mL-1 10.1016/j.bmcl.2018.06.039
Streptococcus pyogenes Streptococcus pyogenes MIC 64.0 ug.mL-1 10.1016/j.bmcl.2022.129115
Streptococcus pyogenes Streptococcus pyogenes MIC 64.0 ug.mL-1 10.1021/jm900729s
Streptococcus pyogenes Streptococcus pyogenes MIC 100.0 ug.mL-1 10.1016/j.bmc.2008.01.027
Streptococcus pyogenes Streptococcus pyogenes MIC 100.0 ug.mL-1 10.1016/S0960-894X(97)00078-4
Streptococcus pyogenes Streptococcus pyogenes MIC 128.0 ug.mL-1 10.1016/j.bmc.2010.02.017
Streptococcus pyogenes Streptococcus pyogenes MIC 128.0 ug.mL-1 10.1016/j.bmcl.2012.06.092
Streptococcus pyogenes Streptococcus pyogenes MIC 128.0 ug.mL-1 10.1016/j.bmcl.2017.06.044
Streptococcus pyogenes Streptococcus pyogenes MIC 128.0 ug.mL-1 10.1016/j.bmcl.2017.07.017
Streptococcus pyogenes Streptococcus pyogenes MIC 128.0 ug.mL-1 10.1016/j.bmcl.2018.06.006
Streptococcus pyogenes Streptococcus pyogenes MIC 128.0 ug.mL-1 10.1016/j.bmcl.2018.06.039
Streptococcus pyogenes Streptococcus pyogenes MIC 128.0 ug.mL-1 10.1016/j.ejmech.2019.03.037
Streptococcus pyogenes Streptococcus pyogenes MIC 128.0 ug.mL-1 10.1016/s0960-894x(00)00106-2
Streptococcus pyogenes Streptococcus pyogenes MIC 256.0 ug.mL-1 10.1016/j.bmcl.2007.03.107
Streptococcus pyogenes Streptococcus pyogenes MIC 256.0 ug.mL-1 10.1016/j.bmcl.2012.12.070
Streptococcus pyogenes Streptococcus pyogenes MIC 256.0 ug.mL-1 10.1016/j.bmcl.2018.09.012
Streptococcus pyogenes Streptococcus pyogenes MIC 256.0 ug.mL-1 10.1016/j.bmcl.2019.126850
Streptococcus pyogenes Streptococcus pyogenes MIC 256.0 ug.mL-1 10.1016/j.bmcl.2021.128110
Streptococcus pyogenes Streptococcus pyogenes MIC 256.0 ug.mL-1 10.1016/j.ejmech.2012.01.023
Streptococcus pyogenes Streptococcus pyogenes MIC 256.0 ug.mL-1 10.1016/j.ejmech.2012.10.054
Streptococcus pyogenes Streptococcus pyogenes MIC 256.0 ug.mL-1 10.1016/j.ejmech.2016.10.065
Streptococcus pyogenes Streptococcus pyogenes MIC 256.0 ug.mL-1 10.1016/j.ejmech.2019.07.022
Streptococcus pyogenes Streptococcus pyogenes MIC 256.0 ug.mL-1 10.1016/j.ejmech.2020.112222
Streptococcus pyogenes Streptococcus pyogenes MIC 512.0 ug.mL-1 10.1016/j.bmcl.2022.128761
Streptococcus pyogenes Streptococcus pyogenes MIC nan None 10.1016/j.bmc.2008.01.027
Streptococcus pyogenes Streptococcus pyogenes MIC50 0.015 ug.mL-1 10.1128/aac.01548-09
Streptococcus pyogenes Streptococcus pyogenes MIC50 0.03 ug.mL-1 10.1128/aac.01123-09
Streptococcus pyogenes Streptococcus pyogenes MIC50 2.0 ug.mL-1 10.1128/aac.00666-06
Streptococcus pyogenes Streptococcus pyogenes MIC50 2.0 ug.mL-1 10.1128/aac.01123-09
Streptococcus pyogenes Streptococcus pyogenes MIC50 4.0 ug.mL-1 10.1128/aac.01065-08
Streptococcus pyogenes Streptococcus pyogenes MIC50 4.0 ug.mL-1 10.1128/aac.01123-09
Streptococcus pyogenes Streptococcus pyogenes MIC50 8.0 ug.mL-1 10.1128/aac.01065-08
Streptococcus pyogenes Streptococcus pyogenes MIC50 64.0 ug.mL-1 10.1128/aac.01123-09
Streptococcus pyogenes Streptococcus pyogenes MIC90 0.06 ug.mL-1 10.1128/aac.01123-09
Streptococcus pyogenes Streptococcus pyogenes MIC90 1.0 ug.mL-1 10.1128/aac.00567-09
Streptococcus pyogenes Streptococcus pyogenes MIC90 2.0 ug.mL-1 10.1128/aac.01548-09
Streptococcus pyogenes Streptococcus pyogenes MIC90 8.0 ug.mL-1 10.1128/aac.00666-06
Streptococcus pyogenes Streptococcus pyogenes MIC90 8.0 ug.mL-1 10.1128/aac.01065-08
Streptococcus pyogenes Streptococcus pyogenes MIC90 8.0 ug.mL-1 10.1128/aac.01123-09
Streptococcus pyogenes Streptococcus pyogenes MIC90 16.0 ug.mL-1 10.1128/aac.01065-08
Streptococcus pyogenes Streptococcus pyogenes MIC90 64.0 ug.mL-1 10.1128/aac.01123-09
Streptococcus pyogenes Streptococcus pyogenes Ratio 2.0 None 10.1016/j.bmc.2015.08.020
Streptococcus pyogenes Streptococcus pyogenes Ratio 2.0 None 10.1016/j.bmcl.2017.02.041
Streptococcus pyogenes Streptococcus pyogenes Ratio 8.0 None 10.1016/j.bmc.2015.08.020
Streptococcus pyogenes Streptococcus pyogenes Ratio 8.0 None 10.1016/j.bmcl.2017.02.041
Streptococcus pyogenes Streptococcus pyogenes Ratio 8.0 None 10.1016/j.ejmech.2019.03.037
Streptococcus pyogenes Streptococcus pyogenes Selectivity ratio 8.0 None 10.1016/j.ejmech.2019.02.073
Streptococcus pyogenes serotype M1 Streptokinase A EC50 60.0 nM None
Streptococcus sp. Streptococcus sp. MIC50/MIC90 nan None 10.1016/s0960-894x(99)00534-x
Streptococcus sp. 'group A' Streptococcus sp. 'group A' EC50 60.0 nM None
Streptococcus sp. 'group B' Streptococcus sp. 'group B' MIC 0.12 ug.mL-1 10.1128/aac.00596-08
Streptococcus sp. 'group B' Streptococcus sp. 'group B' MIC 1.0 ug.mL-1 10.1128/aac.00596-08
Streptococcus sp. 'group B' Streptococcus sp. 'group B' MIC 2.0 ug.mL-1 10.1128/aac.00596-08
Toxoplasma gondii Toxoplasma gondii IC50 31000.0 nM 10.1021/jm101593u
None ADMET Activity 54.3 % 10.1128/aac.00532-07
None ADMET Activity 57.7 % 10.1128/aac.00532-07
None ADMET Activity nan None 10.1128/aac.00140-07
None ADMET CL 7.3 mL.min-1.kg-1 10.1124/dmd.108.020479
None ADMET Cmax 3342.42 nM 10.1021/acs.jmedchem.9b01159
None ADMET Drug uptake 0.0 % 10.1021/jm101317f
None ADMET Drug uptake 1.0 % 10.1021/jm101317f
None ADMET Drug uptake 2.0 % 10.1021/jm101317f
None ADMET Drug uptake 4.0 % 10.1021/jm101317f
None ADMET Drug uptake 16.0 % 10.1021/jm101317f
None ADMET Drug uptake 25.0 % 10.1021/jm101317f
None ADMET Drug uptake 35.0 % 10.1016/j.ejmech.2017.03.056
None ADMET Drug uptake 36.0 % 10.1021/jm101317f
None ADMET Drug uptake 66.0 % 10.1021/jm101317f
None ADMET Drug uptake 127.0 % 10.1021/jm101317f
None ADMET Fu 0.113 None 10.1021/acs.jmedchem.0c02011
None ADMET Fu 0.377 None 10.1021/acs.jmedchem.0c02011
None ADMET K(p,uu,brain) 0.014 None 10.1021/acs.jmedchem.0c02011
None ADMET Log K 0.63 None 10.1021/jm960436i
None ADMET MRT 3.4 hr 10.1124/dmd.108.020479
None ADMET Papp 3.5 ucm/s 10.1124/dmd.110.034629
None ADMET Papp 9.4 ucm/s 10.1124/dmd.110.034629
None ADMET Papp 10.0 10'-6 cm/s 10.1021/acs.jmedchem.8b01259
None ADMET Papp 11.9 ucm/s 10.1124/dmd.110.034629
None ADMET Papp 18.0 ucm/s 10.1124/dmd.110.034629
None ADMET pCF 0.011 None 10.1021/jm960436i
None ADMET pNF 1.601 None 10.1021/jm960436i
None ADMET Ratio 0.8 None 10.1124/dmd.110.034629
None ADMET Ratio 1.955 None 10.1021/acs.jmedchem.0c02011
None ADMET Ratio 5.1 None 10.1124/dmd.110.034629
None ADMET Ratio 48.0 None 10.1124/dmd.110.034629
None ADMET Ratio 85.0 None 10.1124/dmd.110.034629
None ADMET Ratio 238.0 None 10.1124/dmd.110.034629
None ADMET T1/2 2.0 hr 10.1021/jm900729s
None ADMET T1/2 2.8 hr 10.1124/dmd.108.020479
None ADMET T1/2 5.0 hr 10.1016/j.bmcl.2019.06.043
None ADMET Vdss 1.5 L.kg-1 10.1124/dmd.108.020479
None Hepatocyte CL 46.0 uL.min-1.(10^6cells)-1 10.1124/dmd.112.045732
None Hepatocyte CL 68.0 uL.min-1.(10^6cells)-1 10.1124/dmd.112.045732
None Hepatotoxicity Alkaline Phosphatase Increase - Activity Score nan None 10.2174/1570163043334794
None Hepatotoxicity Alkaline Phosphatase Increase - Index Value 3.1 None 10.2174/1570163043334794
None Hepatotoxicity Alkaline Phosphatase Increase - Number of Reports 4.0 None 10.2174/1570163043334794
None Hepatotoxicity Composite Activity - Active 0.0 None 10.2174/1570163043334794
None Hepatotoxicity Composite Activity - Marginal 3.0 None 10.2174/1570163043334794
None Hepatotoxicity Composite Activity - Score nan None 10.2174/1570163043334794
None Hepatotoxicity GGT Increase - Activity Score nan None 10.2174/1570163043334794
None Hepatotoxicity GGT Increase - Index Value 1.5 None 10.2174/1570163043334794
None Hepatotoxicity GGT Increase - Number of Reports 4.0 None 10.2174/1570163043334794
None Hepatotoxicity Hepatotoxicity nan None 10.1021/tx1000865
None Hepatotoxicity Hepatotoxicity nan None 10.1021/tx900326k
None Hepatotoxicity Hepatotoxicity nan None 10.1124/dmd.110.035113
None Hepatotoxicity HepSE_bilirubinemia 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_cholecystitis 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_cholelithiasis 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_cirrhosis 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_Combined Scores 4.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_elevated liver function tests 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_hepatic failure 1.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_hepatic necrosis 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_hepatitis 1.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_hepatomegaly 1.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_jaundice 1.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_liver disease 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_liver fatty 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_liver function tests abnormal 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity LDH Increase - Activity Score nan None 10.2174/1570163043334794
None Hepatotoxicity LDH Increase - Index Value 1.4 None 10.2174/1570163043334794
None Hepatotoxicity LDH Increase - Number of Reports 4.0 None 10.2174/1570163043334794
None Hepatotoxicity SGOT Increase - Activity Score nan None 10.2174/1570163043334794
None Hepatotoxicity SGOT Increase - Index Value 3.8 None 10.2174/1570163043334794
None Hepatotoxicity SGOT Increase - Number of Reports 4.0 None 10.2174/1570163043334794
None Hepatotoxicity SGPT Increase - Activity Score nan None 10.2174/1570163043334794
None Hepatotoxicity SGPT Increase - Index Value 3.3 None 10.2174/1570163043334794
None Hepatotoxicity SGPT Increase - Number of Reports 4.0 None 10.2174/1570163043334794
None Keratinocyte Activity nan None 10.1128/aac.00140-07
None NON-PROTEIN TARGET Fu 0.23 None 10.1124/dmd.108.020479
None NON-PROTEIN TARGET Hepatotoxicity (acute) 5.6 % 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (animal toxicity known) nan None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (benign tumour) 0.0 None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (granulomatous hepatitis) 0.0 None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (mechanism) nan None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (moderate) 47.0 None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (moderate) 50.6 % 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (time to onset) nan None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET IZ 21.0 mm 10.1016/j.ejmech.2011.12.021
None NON-PROTEIN TARGET MBC 0.5 ug ml-1 10.1128/aac.01247-08
None NON-PROTEIN TARGET MBC 1.0 ug ml-1 10.1128/aac.01247-08
None NON-PROTEIN TARGET MBC 2.0 ug ml-1 10.1128/aac.01247-08
None NON-PROTEIN TARGET MBC 4.0 ug ml-1 10.1128/aac.01247-08
None NON-PROTEIN TARGET MBC90 1.0 ug ml-1 10.1128/aac.01247-08
None NON-PROTEIN TARGET MIC 5e-07 ug.mL-1 10.1128/aac.00724-09
None NON-PROTEIN TARGET MIC 2e-06 ug.mL-1 10.1128/aac.00724-09
None NON-PROTEIN TARGET MIC 1.6e-05 ug.mL-1 10.1128/aac.00724-09
None NON-PROTEIN TARGET MIC 0.0019 ug.mL-1 10.1128/aac.01247-08
None NON-PROTEIN TARGET MIC 0.0039 ug.mL-1 10.1128/aac.01247-08
None NON-PROTEIN TARGET MIC 0.004 ug.mL-1 10.1021/jm8000136
None NON-PROTEIN TARGET MIC 0.0079 ug.mL-1 10.1128/aac.01247-08
None NON-PROTEIN TARGET MIC 0.016 ug.mL-1 10.1128/aac.00044-08
None NON-PROTEIN TARGET MIC 0.03 ug.mL-1 10.1128/aac.00695-08
None NON-PROTEIN TARGET MIC 0.063 ug.mL-1 10.1021/jm8000136
None NON-PROTEIN TARGET MIC 0.125 ug.mL-1 10.1128/aac.01349-08
None NON-PROTEIN TARGET MIC 0.5 ug.mL-1 10.1128/aac.00695-08
None NON-PROTEIN TARGET MIC 4.0 ug.mL-1 10.1128/aac.01349-08
None NON-PROTEIN TARGET MIC 32.0 ug.mL-1 10.1128/aac.00695-08
None NON-PROTEIN TARGET MIC50 4e-06 ug.mL-1 10.1128/aac.00724-09
None NON-PROTEIN TARGET MIC50 3.2e-05 ug.mL-1 10.1128/aac.00724-09
None NON-PROTEIN TARGET MIC50 0.25 ug.mL-1 10.1128/aac.00898-09
None NON-PROTEIN TARGET MIC50 128.0 ug.mL-1 10.1128/aac.00898-09
None NON-PROTEIN TARGET MIC90 8e-06 ug.mL-1 10.1128/aac.00724-09
None NON-PROTEIN TARGET MIC90 6.3e-05 ug.mL-1 10.1128/aac.00724-09
None NON-PROTEIN TARGET MIC90 0.0079 ug.mL-1 10.1128/aac.01247-08
None NON-PROTEIN TARGET MIC90 128.0 ug.mL-1 10.1128/aac.00898-09
None No relevant target CLogP 0.0 None 10.1021/jm960436i
None No relevant target CLogP 1.276 None 10.1021/jm960436i
None No relevant target CLogP 3.16 None 10.1021/jm960436i
None No relevant target LogD 1.57 None 10.1021/jm960436i
None No relevant target LogD 3.5 None 10.1016/j.ejmech.2017.03.056
None No relevant target LogD 3.9 None 10.1016/j.bmc.2007.09.044
None No relevant target -log(solubility) 5.87 None 10.1016/j.bmcl.2015.02.013
None No relevant target -log(solubility) 6.17 None 10.1016/j.bmcl.2015.02.013
None No relevant target -log(solubility) 7.35 None 10.1016/j.bmcl.2015.02.013
None No relevant target -log(solubility) nan None 10.1016/j.bmcl.2015.02.013
None No relevant target pKa 8.99 None 10.1007/s11095-013-1232-z
None No relevant target pKa 14.1 None 10.1124/dmd.112.050278
None No relevant target pKa1 8.99 None 10.1021/jm960436i
None Phospholipidosis Phospholipidosis nan None 10.1021/mp100103e
None Phospholipidosis Phospholipidosis nan None 10.1080/15376510701857262
None Unchecked Activity 31.5 % 10.1021/acs.jnatprod.8b00939
None Unchecked Activity 67.7 % 10.1021/acs.jnatprod.8b00939
None Unchecked APDc 48.18 None 10.6019/CHEMBL4295262
None Unchecked APDc 53.12 None 10.6019/CHEMBL4295262
None Unchecked APDc 61.24 None 10.6019/CHEMBL4295262
None Unchecked APDc 79.49 None 10.6019/CHEMBL4295262
None Unchecked FC 2.0 None 10.1128/aac.01592-06
None Unchecked FPDc 0.03271 None 10.6019/CHEMBL4295262
None Unchecked FPDc 0.03502 None 10.6019/CHEMBL4295262
None Unchecked FPDc 0.03611 None 10.6019/CHEMBL4295262
None Unchecked FPDc 0.04288 None 10.6019/CHEMBL4295262
None Unchecked FPD measurement 0.03271 FPDc 10.6019/CHEMBL4295262
None Unchecked FPD measurement 0.03502 FPDc 10.6019/CHEMBL4295262
None Unchecked FPD measurement 0.03611 FPDc 10.6019/CHEMBL4295262
None Unchecked FPD measurement 0.04288 FPDc 10.6019/CHEMBL4295262
None Unchecked FPD measurement 48.18 FPDc 10.6019/CHEMBL4295262
None Unchecked FPD measurement 53.12 FPDc 10.6019/CHEMBL4295262
None Unchecked FPD measurement 61.24 FPDc 10.6019/CHEMBL4295262
None Unchecked FPD measurement 79.49 FPDc 10.6019/CHEMBL4295262
None Unchecked Hepatotoxicity (acute) 13.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (association with vascular disease) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (choleostasis) 6.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (chronic liver disease) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (cirrhosis) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (comment) nan None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (cytolytic) 9.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (malignant tumour) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (severe hepatitis) 4.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (steatosis) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (successful reintroduction) nan None 10.1016/s0399-8320(04)95062-2
None Unchecked IC50 29650.0 nM None
None Unchecked IC50 51990.0 nM None
None Unchecked IC50 125469.0 nM None
None Unchecked IC50 nan None None
None Unchecked Kcat 0.311 /s 10.1128/aac.01570-09
None Unchecked Kcat/Km 6.77 10'3/s/M 10.1128/aac.01570-09
None Unchecked Ki nan None None
None Unchecked Km 45900.0 nM 10.1128/aac.01570-09
None Unchecked MIC50 0.3 ug.mL-1 10.1021/jm980240d
None Unchecked MIC50 40.0 ug.mL-1 10.1021/jm980240d
None Unchecked MIC90 40.0 ug.mL-1 10.1021/jm980240d
None Unchecked Potency 5623.4 nM None
None Unchecked Potency 35481.3 nM None
None Unchecked Time nan None 10.1128/aac.00620-10
None Unchecked TIME 0.005556 hr 10.1128/aac.00620-10

Metabolism Information

AKRT ID Reaction Reaction Link ID
AKRT010287 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O.Nc1ncnc2c1ncn2[C@@H]1O[C@H](COP(=O)(O)OP(=O)(O)OP(=O)(O)O)[C@@H](O)[C@H]1O>>CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2OP(=O)(O)O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O.Nc1ncnc2c1ncn2[C@@H]1O[C@H](COP(=O)(O)OP(=O)(O)O)[C@@H](O)[C@H]1O None
AKRT010288 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O>>CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2OP(=O)(O)O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O enzymemap_43341