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name Structure Reference Source Properties Activities Metabolism

Huperzine A

AlkaPlorer ID: AK014811

Synonym: '', '(-)-Huperzine A', 'Selagine', 'Huperzine A', 'Kimpukan A'

IUPAC Name: (1S,9R,13E)-1-amino-13-ethylidene-11-methyl-6-azatricyclo[7.3.1.02,7]trideca-2(7),3,10-trien-5-one

Structure

SMILES: C/C=C1\[C@H]2C=C(C)C[C@@]1(N)C1=CC=C(O)N=C1C2

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InChI: InChI=1S/C15H18N2O/c1-3-11-10-6-9(2)8-15(11,16)12-4-5-14(18)17-13(12)7-10/h3-6,10H,7-8,16H2,1-2H3,(H,17,18)/b11-3+/t10-,15-/m0/s1

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InChIKey: ZRJBHWIHUMBLCN-HZRLMBICSA-N

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Reference

PubChem CID: 9794806

NPASS: NPC482954

Source

Species Genus Family Order Class Phylum Kingdom Domain
Huperzia serrata Huperzia Lycopodiaceae Lycopodiales Lycopodiopsida Streptophyta Viridiplantae Eukaryota

Properties Information

Molecule Weight: 242.322

TPSA？: 59.14

MolLogP？: 2.4098000000000006

Number of H-Donors: 2

Number of H-Acceptors: 3

RingCount: 3

Activities Information

Organism Target Name Standard Type Standard Value Standard Units doi
Bacillus subtilis Bacillus subtilis IC50 nan None 10.1021/np2009626
Bos taurus Acetylcholinesterase IC50 53.0 nM 10.1016/j.bmc.2007.08.043
Bos taurus Acetylcholinesterase IC50 74.0 nM 10.1016/j.bmc.2008.06.022
Bos taurus Acetylcholinesterase IC50 74.0 nM 10.1021/jm000980y
Bos taurus Acetylcholinesterase IC50 74.0 nM 10.1021/jm010949b
Bos taurus Acetylcholinesterase IC50 74.0 nM 10.1021/jm0496741
Bos taurus Acetylcholinesterase IC50 74.0 nM 10.1021/jm060945c
Bos taurus Acetylcholinesterase IC50 74.0 nM 10.1021/jm980620z
Bos taurus Acetylcholinesterase IC50 nan None 10.1021/jm060945c
Bos taurus Acetylcholinesterase Ki 5.9 nM 10.1016/0960-894X(96)00012-1
Bos taurus Acetylcholinesterase Ki 5.9 nM 10.1016/s0960-894x(00)00494-7
Bos taurus Acetylcholinesterase Ki 23.6 nM 10.1016/0960-894X(96)00012-1
Bos taurus Acetylcholinesterase Ki 24.0 nM 10.1016/s0960-894x(02)00204-4
Bos taurus Acetylcholinesterase k_off 0.000334 s-1 10.1016/0960-894X(96)00012-1
Bos taurus Acetylcholinesterase k_off 0.0003674 s-1 10.1016/0960-894X(96)00012-1
Bos taurus Acetylcholinesterase k_on 0.01553 M-1.s-1 10.1016/0960-894X(96)00012-1
Bos taurus Acetylcholinesterase k_on 0.05678 M-1.s-1 10.1016/0960-894X(96)00012-1
Bos taurus Progesterone receptor IC50 nan None None
Bos taurus Progesterone receptor Ki nan None None
Caenorhabditis elegans Caenorhabditis elegans Activity nan None 10.1039/C4MD00305E
Caenorhabditis elegans Caenorhabditis elegans TIME 48.3 hr 10.1039/C4MD00305E
Cavia porcellus Leukotriene C4 synthase IC50 nan None None
Cavia porcellus Leukotriene C4 synthase Ki nan None None
Cavia porcellus Serotonin 4 (5-HT4) receptor IC50 nan None None
Cavia porcellus Serotonin 4 (5-HT4) receptor Ki nan None None
Electrophorus electricus Acetylcholinesterase IC50 120.0 nM 10.1021/np100889v
Electrophorus electricus Acetylcholinesterase Inhibition 97.29 % 10.1016/j.bmc.2012.09.040
Equus caballus Cholinesterase Inhibition 11.85 % 10.1016/j.bmc.2012.09.040
Escherichia coli Escherichia coli DIZ nan None 10.1016/j.bmcl.2010.08.024
Eurhopalus australis Eurhopalus australis Activity 1.5 mg/ml 10.1021/jf0106087
Eurhopalus australis Eurhopalus australis Activity 3.0 % 10.1021/jf0106087
Eurhopalus australis Eurhopalus australis LD50 110.0 ppm 10.1021/jf0106087
Fusarium oxysporum Fusarium oxysporum Activity nan None 10.1016/j.bmcl.2010.08.024
Homo sapiens Acetylcholinesterase IC50 0.54 nM 10.1021/np500412f
Homo sapiens Acetylcholinesterase IC50 5.0 nM 10.1016/0960-894X(96)00337-X
Homo sapiens Acetylcholinesterase IC50 5.0 nM 10.1016/j.bmcl.2010.12.041
Homo sapiens Acetylcholinesterase IC50 5.0 nM 10.1016/j.bmcl.2015.06.047
Homo sapiens Acetylcholinesterase IC50 12.0 nM 10.1021/np2009626
Homo sapiens Acetylcholinesterase IC50 21.0 nM 10.1016/j.bmc.2009.08.017
Homo sapiens Acetylcholinesterase IC50 29.0 nM None
Homo sapiens Acetylcholinesterase IC50 45.0 nM 10.1016/j.bmcl.2012.11.083
Homo sapiens Acetylcholinesterase IC50 47.0 nM 10.1021/jm010491d
Homo sapiens Acetylcholinesterase IC50 47.0 nM 10.1021/jm049309+
Homo sapiens Acetylcholinesterase IC50 47.0 nM 10.1021/jm050578p
Homo sapiens Acetylcholinesterase IC50 125.0 nM 10.1021/np4003355
Homo sapiens Acetylcholinesterase IC50 150.0 nM 10.1016/0960-894X(96)00102-3
Homo sapiens Acetylcholinesterase IC50 260.0 nM 10.1021/jm000980y
Homo sapiens Acetylcholinesterase IC50 260.0 nM 10.1021/jm010949b
Homo sapiens Acetylcholinesterase IC50 260.0 nM 10.1021/jm0496741
Homo sapiens Acetylcholinesterase IC50 260.0 nM 10.1021/jm060945c
Homo sapiens Acetylcholinesterase IC50 1700.0 nM 10.1021/np100494u
Homo sapiens Acetylcholinesterase Inhibition 50.0 % 10.1021/np0103564
Homo sapiens Acetylcholinesterase Inhibition 98.0 % 10.1016/j.bmcl.2010.08.024
Homo sapiens Acetylcholinesterase Inhibition 100.0 % 10.1016/j.ejmech.2014.05.020
Homo sapiens Acetylcholinesterase Ki 47.0 nM 10.1021/jm060257t
Homo sapiens Acetylcholinesterase Ki nan None None
Homo sapiens Acetylcholinesterase Ratio 0.28 None 10.1021/jm010949b
Homo sapiens Adenosine A1 receptor IC50 nan None None
Homo sapiens Adenosine A1 receptor Ki nan None None
Homo sapiens Adenosine A2a receptor IC50 nan None None
Homo sapiens Adenosine A2a receptor Ki nan None None
Homo sapiens Adenosine A3 receptor IC50 nan None None
Homo sapiens Adenosine A3 receptor Ki nan None None
Homo sapiens Alpha-1d adrenergic receptor IC50 nan None None
Homo sapiens Alpha-1d adrenergic receptor Ki nan None None
Homo sapiens Alpha-2a adrenergic receptor IC50 nan None None
Homo sapiens Alpha-2a adrenergic receptor Ki nan None None
Homo sapiens Alpha-2b adrenergic receptor IC50 nan None None
Homo sapiens Alpha-2b adrenergic receptor Ki nan None None
Homo sapiens Alpha-2c adrenergic receptor IC50 nan None None
Homo sapiens Alpha-2c adrenergic receptor Ki nan None None
Homo sapiens Angiotensin II type 2 (AT-2) receptor IC50 nan None None
Homo sapiens Angiotensin II type 2 (AT-2) receptor Ki nan None None
Homo sapiens Beta-1 adrenergic receptor IC50 nan None None
Homo sapiens Beta-1 adrenergic receptor Ki nan None None
Homo sapiens Beta-2 adrenergic receptor IC50 nan None None
Homo sapiens Beta-2 adrenergic receptor Ki nan None None
Homo sapiens Beta-3 adrenergic receptor IC50 nan None None
Homo sapiens Beta-3 adrenergic receptor Ki nan None None
Homo sapiens Bradykinin B2 receptor IC50 nan None None
Homo sapiens Bradykinin B2 receptor Ki nan None None
Homo sapiens Butyrylcholinesterase IC50 100.0 nM 10.1016/j.bmcl.2010.12.041
Homo sapiens Butyrylcholinesterase IC50 10000.0 nM 10.1021/jm000980y
Homo sapiens Butyrylcholinesterase IC50 10000.0 nM 10.1021/jm010491d
Homo sapiens Butyrylcholinesterase IC50 10000.0 nM 10.1021/jm010949b
Homo sapiens Butyrylcholinesterase IC50 10000.0 nM 10.1021/jm049309+
Homo sapiens Butyrylcholinesterase IC50 10000.0 nM 10.1021/jm0496741
Homo sapiens Butyrylcholinesterase IC50 10000.0 nM 10.1021/jm050578p
Homo sapiens Butyrylcholinesterase IC50 10000.0 nM 10.1021/jm060945c
Homo sapiens Butyrylcholinesterase IC50 100000.0 nM 10.1021/jm980620z
Homo sapiens Butyrylcholinesterase Ki 1000.0 nM 10.1021/jm060257t
Homo sapiens Calcitonin receptor IC50 nan None None
Homo sapiens Calcitonin receptor Ki nan None None
Homo sapiens Cannabinoid CB1 receptor IC50 nan None None
Homo sapiens Cannabinoid CB1 receptor Ki nan None None
Homo sapiens Carbonic anhydrase II IC50 nan None None
Homo sapiens Carbonic anhydrase II Ki nan None None
Homo sapiens Caspase-1 IC50 nan None None
Homo sapiens Caspase-1 Ki nan None None
Homo sapiens Cathepsin G IC50 nan None None
Homo sapiens Cathepsin G Ki nan None None
Homo sapiens C-C chemokine receptor type 2 IC50 nan None None
Homo sapiens C-C chemokine receptor type 2 Ki nan None None
Homo sapiens C-C chemokine receptor type 4 IC50 nan None None
Homo sapiens C-C chemokine receptor type 4 Ki nan None None
Homo sapiens C-C chemokine receptor type 5 IC50 nan None None
Homo sapiens C-C chemokine receptor type 5 Ki nan None None
Homo sapiens Cholecystokinin A receptor IC50 nan None None
Homo sapiens Cholecystokinin A receptor Ki nan None None
Homo sapiens Cholinesterases; ACHE & BCHE Ratio 38.0 None 10.1021/jm010949b
Homo sapiens Cholinesterases; ACHE & BCHE Ratio IC50 212.0 None 10.1021/jm050578p
Homo sapiens Cholinesterases; ACHE & BCHE Selectivity 212.0 None 10.1021/jm010491d
Homo sapiens Cyclooxygenase-1 IC50 nan None None
Homo sapiens Cyclooxygenase-1 Ki nan None None
Homo sapiens Cyclooxygenase-2 IC50 nan None None
Homo sapiens Cyclooxygenase-2 Ki nan None None
Homo sapiens Cysteinyl leukotriene receptor 1 IC50 nan None None
Homo sapiens Cysteinyl leukotriene receptor 1 Ki nan None None
Homo sapiens Cytochrome P450 1A2 IC50 nan None None
Homo sapiens Cytochrome P450 1A2 Ki nan None None
Homo sapiens Cytochrome P450 2A6 IC50 nan None None
Homo sapiens Cytochrome P450 2A6 Ki nan None None
Homo sapiens Cytochrome P450 2C19 IC50 nan None None
Homo sapiens Cytochrome P450 2C19 Ki nan None None
Homo sapiens Cytochrome P450 2C9 IC50 nan None None
Homo sapiens Cytochrome P450 2C9 Ki nan None None
Homo sapiens Cytochrome P450 2D6 IC50 nan None None
Homo sapiens Cytochrome P450 2D6 Ki nan None None
Homo sapiens Cytochrome P450 2E1 IC50 nan None None
Homo sapiens Cytochrome P450 2E1 Ki nan None None
Homo sapiens Cytochrome P450 3A4 IC50 nan None None
Homo sapiens Cytochrome P450 3A4 Ki nan None None
Homo sapiens Delta opioid receptor IC50 nan None None
Homo sapiens Delta opioid receptor Ki nan None None
Homo sapiens Dopamine D1 receptor IC50 nan None None
Homo sapiens Dopamine D1 receptor Ki nan None None
Homo sapiens Dopamine D2 receptor IC50 nan None None
Homo sapiens Dopamine D2 receptor Ki nan None None
Homo sapiens Dopamine D3 receptor IC50 nan None None
Homo sapiens Dopamine D3 receptor Ki nan None None
Homo sapiens Dopamine D4 receptor IC50 nan None None
Homo sapiens Dopamine D4 receptor Ki nan None None
Homo sapiens Dopamine transporter IC50 nan None None
Homo sapiens Dopamine transporter Ki nan None None
Homo sapiens Endothelin receptor ET-A IC50 nan None None
Homo sapiens Endothelin receptor ET-A Ki nan None None
Homo sapiens Epidermal growth factor receptor erbB1 IC50 nan None None
Homo sapiens Epidermal growth factor receptor erbB1 Ki nan None None
Homo sapiens Estrogen receptor alpha IC50 nan None None
Homo sapiens Estrogen receptor alpha Ki nan None None
Homo sapiens Estrogen receptor beta IC50 nan None None
Homo sapiens Estrogen receptor beta Ki nan None None
Homo sapiens Glucocorticoid receptor IC50 nan None None
Homo sapiens Glucocorticoid receptor Ki nan None None
Homo sapiens HERG IC50 nan None None
Homo sapiens HERG Ki nan None None
Homo sapiens Histamine H1 receptor IC50 nan None None
Homo sapiens Histamine H1 receptor Ki nan None None
Homo sapiens Histamine H2 receptor IC50 nan None None
Homo sapiens Histamine H2 receptor Ki nan None None
Homo sapiens HMG-CoA reductase IC50 nan None None
Homo sapiens HMG-CoA reductase Ki nan None None
Homo sapiens Interleukin-8 receptor A IC50 nan None None
Homo sapiens Interleukin-8 receptor A Ki nan None None
Homo sapiens Interleukin-8 receptor B IC50 nan None None
Homo sapiens Interleukin-8 receptor B Ki nan None None
Homo sapiens Kappa opioid receptor IC50 nan None None
Homo sapiens Kappa opioid receptor Ki nan None None
Homo sapiens Leukocyte common antigen IC50 nan None None
Homo sapiens Leukocyte common antigen Ki nan None None
Homo sapiens Leukocyte elastase IC50 nan None None
Homo sapiens Leukocyte elastase Ki nan None None
Homo sapiens MAP kinase ERK1 IC50 nan None None
Homo sapiens MAP kinase ERK1 Ki nan None None
Homo sapiens MAP kinase ERK2 IC50 nan None None
Homo sapiens MAP kinase ERK2 Ki nan None None
Homo sapiens MAP kinase p38 alpha IC50 nan None None
Homo sapiens MAP kinase p38 alpha Ki nan None None
Homo sapiens Matrix metalloproteinase-1 IC50 nan None None
Homo sapiens Matrix metalloproteinase-1 Ki nan None None
Homo sapiens Matrix metalloproteinase 9 IC50 nan None None
Homo sapiens Matrix metalloproteinase 9 Ki nan None None
Homo sapiens Melanocortin receptor 3 IC50 nan None None
Homo sapiens Melanocortin receptor 3 Ki nan None None
Homo sapiens Melanocortin receptor 4 IC50 nan None None
Homo sapiens Melanocortin receptor 4 Ki nan None None
Homo sapiens Melanocortin receptor 5 IC50 nan None None
Homo sapiens Melanocortin receptor 5 Ki nan None None
Homo sapiens Monoamine oxidase A IC50 nan None None
Homo sapiens Monoamine oxidase A Ki nan None None
Homo sapiens Mu opioid receptor IC50 nan None None
Homo sapiens Mu opioid receptor Ki nan None None
Homo sapiens Muscarinic acetylcholine receptor M1 IC50 nan None None
Homo sapiens Muscarinic acetylcholine receptor M1 Ki nan None None
Homo sapiens Muscarinic acetylcholine receptor M2 IC50 nan None None
Homo sapiens Muscarinic acetylcholine receptor M2 Ki nan None None
Homo sapiens Muscarinic acetylcholine receptor M3 IC50 nan None None
Homo sapiens Muscarinic acetylcholine receptor M3 Ki nan None None
Homo sapiens Muscarinic acetylcholine receptor M4 IC50 nan None None
Homo sapiens Muscarinic acetylcholine receptor M4 Ki nan None None
Homo sapiens Muscarinic acetylcholine receptor M5 IC50 nan None None
Homo sapiens Muscarinic acetylcholine receptor M5 Ki nan None None
Homo sapiens Neurokinin 1 receptor IC50 nan None None
Homo sapiens Neurokinin 1 receptor Ki nan None None
Homo sapiens Neurokinin 2 receptor IC50 nan None None
Homo sapiens Neurokinin 2 receptor Ki nan None None
Homo sapiens Neuropeptide Y receptor type 1 IC50 nan None None
Homo sapiens Neuropeptide Y receptor type 1 Ki nan None None
Homo sapiens Neuropeptide Y receptor type 2 IC50 nan None None
Homo sapiens Neuropeptide Y receptor type 2 Ki nan None None
Homo sapiens Norepinephrine transporter IC50 nan None None
Homo sapiens Norepinephrine transporter Ki nan None None
Homo sapiens Phosphodiesterase 5A IC50 nan None None
Homo sapiens Phosphodiesterase 5A Ki nan None None
Homo sapiens Platelet activating factor receptor IC50 nan None None
Homo sapiens Platelet activating factor receptor Ki nan None None
Homo sapiens Protein kinase C alpha IC50 nan None None
Homo sapiens Protein kinase C alpha Ki nan None None
Homo sapiens Receptor protein-tyrosine kinase erbB-2 IC50 nan None None
Homo sapiens Receptor protein-tyrosine kinase erbB-2 Ki nan None None
Homo sapiens Serine/threonine protein phosphatase 2B catalytic subunit, alpha isoform IC50 nan None None
Homo sapiens Serine/threonine protein phosphatase 2B catalytic subunit, alpha isoform Ki nan None None
Homo sapiens Serotonin 2a (5-HT2a) receptor IC50 nan None None
Homo sapiens Serotonin 2a (5-HT2a) receptor Ki nan None None
Homo sapiens Serotonin 2b (5-HT2b) receptor IC50 nan None None
Homo sapiens Serotonin 2b (5-HT2b) receptor Ki nan None None
Homo sapiens Serotonin 2c (5-HT2c) receptor IC50 nan None None
Homo sapiens Serotonin 2c (5-HT2c) receptor Ki nan None None
Homo sapiens Serotonin 6 (5-HT6) receptor IC50 nan None None
Homo sapiens Serotonin 6 (5-HT6) receptor Ki nan None None
Homo sapiens Serotonin transporter IC50 nan None None
Homo sapiens Serotonin transporter Ki nan None None
Homo sapiens Sigma opioid receptor IC50 nan None None
Homo sapiens Sigma opioid receptor Ki nan None None
Homo sapiens Solute carrier organic anion transporter family member 1B1 Inhibition 93.86 % 10.1124/mol.112.084152
Homo sapiens Solute carrier organic anion transporter family member 1B3 Inhibition 101.26 % 10.1124/mol.112.084152
Homo sapiens Thromboxane-A synthase IC50 nan None None
Homo sapiens Thromboxane-A synthase Ki nan None None
Homo sapiens Tyrosine-protein kinase FYN IC50 nan None None
Homo sapiens Tyrosine-protein kinase FYN Ki nan None None
Homo sapiens Tyrosine-protein kinase LCK IC50 nan None None
Homo sapiens Tyrosine-protein kinase LCK Ki nan None None
Homo sapiens Vascular endothelial growth factor receptor 1 IC50 nan None None
Homo sapiens Vascular endothelial growth factor receptor 1 Ki nan None None
Homo sapiens Vasoactive intestinal polypeptide receptor 1 IC50 nan None None
Homo sapiens Vasoactive intestinal polypeptide receptor 1 Ki nan None None
Homo sapiens Vasopressin V1a receptor IC50 nan None None
Homo sapiens Vasopressin V1a receptor Ki nan None None
Lucilia cuprina Lucilia cuprina Activity 8.0 % 10.1021/jf0106087
Lucilia cuprina Lucilia cuprina LD50 2.38 mg/ml 10.1021/jf0106087
Mus musculus Acetylcholinesterase IC50 82.0 nM 10.1021/jm400990p
Mus musculus Mus musculus Activity nan None 10.1016/j.bmcl.2014.10.049
Mus musculus Mus musculus Activity nan None 10.1021/acs.jnatprod.5b00234
Mus musculus Nitric oxide synthase, inducible IC50 nan None None
Mus musculus Nitric oxide synthase, inducible Ki nan None None
Oryctolagus cuniculus Angiotensin-converting enzyme IC50 nan None None
Oryctolagus cuniculus Angiotensin-converting enzyme Ki nan None None
Oryctolagus cuniculus Arachidonate 15-lipoxygenase IC50 nan None None
Oryctolagus cuniculus Arachidonate 15-lipoxygenase Ki nan None None
Rattus norvegicus Acetylcholinesterase IC50 44.5 nM 10.1021/jm00116a010
Rattus norvegicus Acetylcholinesterase IC50 53.0 nM 10.1016/j.bmcl.2005.05.132
Rattus norvegicus Acetylcholinesterase IC50 65.0 nM 10.1016/j.bmc.2012.11.044
Rattus norvegicus Acetylcholinesterase IC50 71.5 nM 10.1021/jm00116a010
Rattus norvegicus Acetylcholinesterase IC50 72.4 nM 10.1016/j.bmc.2006.11.009
Rattus norvegicus Acetylcholinesterase IC50 72.4 nM 10.1021/jm0496178
Rattus norvegicus Acetylcholinesterase IC50 80.0 nM 10.1016/s0960-894x(98)00280-7
Rattus norvegicus Acetylcholinesterase IC50 80.0 nM 10.1021/jm00018a025
Rattus norvegicus Acetylcholinesterase IC50 94.0 nM 10.1016/0960-894X(96)00102-3
Rattus norvegicus Acetylcholinesterase IC50 114.0 nM 10.1016/s0960-894x(99)00396-0
Rattus norvegicus Acetylcholinesterase IC50 114.0 nM 10.1021/jm701253t
Rattus norvegicus Acetylcholinesterase IC50 nan nM 10.1021/jm00015a020
Rattus norvegicus Acetylcholinesterase Ki 24.0 nM 10.1016/s0960-894x(01)00518-2
Rattus norvegicus Acetylcholinesterase and butyrylcholinesterase (AChE and BChE) Selectivity 1170.0 None 10.1016/s0960-894x(99)00396-0
Rattus norvegicus Acetylcholinesterase and butyrylcholinesterase (AChE and BChE) Selectivity index 970.0 None 10.1021/jm0496178
Rattus norvegicus Aldose reductase IC50 nan None None
Rattus norvegicus Aldose reductase Ki nan None None
Rattus norvegicus Alpha-1a adrenergic receptor IC50 nan None None
Rattus norvegicus Alpha-1a adrenergic receptor Ki nan None None
Rattus norvegicus Alpha-1b adrenergic receptor IC50 nan None None
Rattus norvegicus Alpha-1b adrenergic receptor Ki nan None None
Rattus norvegicus Androgen Receptor IC50 nan None None
Rattus norvegicus Androgen Receptor Ki nan None None
Rattus norvegicus Butyrylcholinesterase IC50 56200.0 nM 10.1016/j.bmcl.2005.05.132
Rattus norvegicus Butyrylcholinesterase IC50 70200.0 nM 10.1016/j.bmc.2006.11.009
Rattus norvegicus Butyrylcholinesterase IC50 135000.0 nM 10.1016/s0960-894x(99)00396-0
Rattus norvegicus Butyrylcholinesterase IC50 702000.0 nM 10.1021/jm0496178
Rattus norvegicus Butyrylcholinesterase IC50 1000000.0 nM 10.1021/jm00018a025
Rattus norvegicus Glycine receptor IC50 nan None None
Rattus norvegicus Glycine receptor Ki nan None None
Rattus norvegicus Insulin receptor IC50 nan None None
Rattus norvegicus Insulin receptor Ki nan None None
Rattus norvegicus Nitric-oxide synthase, brain IC50 nan None None
Rattus norvegicus Nitric-oxide synthase, brain Ki nan None None
Rattus norvegicus Serotonin 1a (5-HT1a) receptor IC50 nan None None
Rattus norvegicus Serotonin 1a (5-HT1a) receptor Ki nan None None
Rattus norvegicus Serotonin 1b (5-HT1b) receptor IC50 nan None None
Rattus norvegicus Serotonin 1b (5-HT1b) receptor Ki nan None None
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Hit score 0.2677 None 10.1101/2020.04.21.054387
Tineola bisselliella Tineola bisselliella Activity 3.0 % 10.1021/jf0106087
Tineola bisselliella Tineola bisselliella LD50 630.0 ppm 10.1021/jf0106087
Torpedo californica Acetylcholinesterase IC50 11.4 nM 10.1016/j.bmc.2009.08.017
Torpedo californica Acetylcholinesterase Inhibition 20.43 % 10.1016/j.bmc.2009.08.017
Torpedo californica Acetylcholinesterase Inhibition 34.56 % 10.1016/j.bmc.2009.08.017
Torpedo californica Acetylcholinesterase Inhibition 53.35 % 10.1016/j.bmc.2009.08.017
Torpedo californica Acetylcholinesterase Inhibition 70.24 % 10.1016/j.bmc.2009.08.017
Torpedo californica Acetylcholinesterase Inhibition 81.93 % 10.1016/j.bmc.2009.08.017
Torpedo californica Acetylcholinesterase Inhibition 85.7 % 10.1016/j.bmc.2009.08.017
Torpedo californica Acetylcholinesterase Inhibition 92.97 % 10.1016/j.bmc.2009.08.017
Torpedo californica Acetylcholinesterase Inhibition 99.67 % 10.1016/j.bmc.2009.08.017
Torpedo californica Acetylcholinesterase Ki 175.0 nM 10.1021/jm701253t
None ADMET IC50 nan None 10.1021/np2009626
None ADMET T1/2 0.5833 hr 10.1016/s0960-894x(00)00494-7
None NON-PROTEIN TARGET AI50 nan None 10.1021/jm980620z
None Unchecked Antagonism nan None 10.1021/jm000980y
None Unchecked IC50 74000.0 nM 10.1016/j.bmc.2012.11.044
None Unchecked IC50 nan None None
None Unchecked Ki nan None None
None Unchecked Ratio 0.28 None 10.1021/jm000980y
None Unchecked Ratio 38.0 None 10.1021/jm000980y
None Unchecked Ratio 1000.0 None 10.1021/jm980620z
None Unchecked Ratio IC50 970.0 None 10.1016/j.bmc.2006.11.009
None Unchecked Ratio IC50 1138.0 None 10.1016/j.bmc.2012.11.044

Metabolism Information