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1-methyl-2-quinolone

AlkaPlorer ID: AK014947

Synonym: 'N-Methylcarbostyril', 'SMR001547359', 'MLS002637847'

IUPAC Name: 1-methylquinolin-2-one

Structure

SMILES: CN1C(=O)C=CC2=CC=CC=C21

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InChI: InChI=1S/C10H9NO/c1-11-9-5-3-2-4-8(9)6-7-10(11)12/h2-7H,1H3

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InChIKey: QYEMNJMSULGQRD-UHFFFAOYSA-N

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Source

Species Genus Family Order Class Phylum Kingdom Domain

Properties Information

Molecule Weight: 159.188

TPSA？: 22.0

MolLogP？: 1.5385

Number of H-Donors: 0

Number of H-Acceptors: 2

RingCount: 2

Activities Information

Organism Target Name Standard Type Standard Value Standard Units doi
Homo sapiens ATPase family AAA domain-containing protein 2 IC50 100000.0 nM 10.1021/acs.jmedchem.6b01583
Homo sapiens Bromodomain-containing protein 4 IC50 73000.0 nM 10.1021/acs.jmedchem.6b01583
Homo sapiens Bromodomain-containing protein 9 IC50 14000.0 nM 10.1021/acs.jmedchem.6b01583
Homo sapiens Bromodomain-containing protein 9 Kd 5.0 nM 10.1021/acs.jmedchem.1c00787
Homo sapiens Bromodomain-containing protein 9 Kd 5000.0 nM 10.1021/acs.jmedchem.5b01514
Homo sapiens Bromodomain-containing protein 9 Kd 5000.0 nM 10.1039/C5MD00209E
Homo sapiens Carbonic anhydrase I Ki 10000.0 nM 10.1021/acsmedchemlett.8b00362
Homo sapiens Carbonic anhydrase II Ki 10000.0 nM 10.1021/acsmedchemlett.8b00362
Homo sapiens Carbonic anhydrase IX Ki 44.6 nM 10.1021/acsmedchemlett.8b00362
Homo sapiens Carbonic anhydrase XII Ki 83.5 nM 10.1021/acsmedchemlett.8b00362
Homo sapiens HepG2 CC50 100000.0 nM 10.1016/j.ejmech.2018.06.001
Homo sapiens Histone acetyltransferase PCAF Delta Tm 2.0 degrees C 10.1021/acs.jmedchem.5b01719
Homo sapiens Histone acetyltransferase PCAF Delta Tm 4.5 degrees C 10.1021/acs.jmedchem.6b01583
Homo sapiens Histone acetyltransferase PCAF IC50 70000.0 nM 10.1021/acs.jmedchem.6b01583
Homo sapiens Peregrin IC50 4800.0 nM 10.1021/acs.jmedchem.6b01583
Leishmania infantum Leishmania infantum IC50 100000.0 nM 10.1016/j.ejmech.2018.06.001
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 6.25 ug.mL-1 10.1016/j.ejmech.2017.06.005
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 25.0 ug.mL-1 10.1016/j.ejmech.2022.114173
Trypanosoma brucei brucei Trypanosoma brucei brucei ED50 0.413 mM 10.1021/jm060429m
Trypanosoma brucei brucei Trypanosoma brucei brucei IC50 50000.0 nM 10.1016/j.ejmech.2018.06.001
None No relevant target LogD -0.15 None 10.1021/jm701549s
None No relevant target LogD 1.52 None 10.1021/jm701549s
None Unchecked IC50 1000000.0 nM 10.1021/acs.jmedchem.7b00389

Metabolism Information