Cinnabaramide E
AlkaPlorer ID: AK015055
Synonym: None
IUPAC Name: (2R,3S,4R)-2-[(S)-[(1S)-cyclohex-2-en-1-yl]-hydroxymethyl]-4-hexyl-3-hydroxy-3-methyl-5-oxopyrrolidine-2-carboxylic acid
Structure
SMILES: CCCCCC[C@H]1C(O)=N[C@](C(=O)O)([C@@H](O)[C@@H]2C=CCCC2)[C@@]1(C)O
InChI: InChI=1S/C19H31NO5/c1-3-4-5-9-12-14-16(22)20-19(17(23)24,18(14,2)25)15(21)13-10-7-6-8-11-13/h7,10,13-15,21,25H,3-6,8-9,11-12H2,1-2H3,(H,20,22)(H,23,24)/t13-,14+,15+,18+,19+/m1/s1
InChIKey: ADDRECXFKLYOGC-MUAMBBPCSA-N
Reference
Cinnabaramides A−G: Analogues of Lactacystin and Salinosporamide from a Terrestrial Streptomycete
PubChem CID: 16109814
LOTUS: LTS0134110
SuperNatural Ⅲ: SN0002409-01
NPASS: NPC234542
{NPAtlas: NPA017304
Source
| Species | Genus | Family | Order | Class | Phylum | Kingdom | Domain |
|---|---|---|---|---|---|---|---|
| Streptomyces sp. | Streptomyces | Streptomycetaceae | Kitasatosporales | Actinomycetes | Actinomycetota | None | Bacteria |
Properties Information
Molecule Weight: 353.4590000000002
TPSA？: 110.35
MolLogP？: 2.834700000000002
Number of H-Donors: 4
Number of H-Acceptors: 4
RingCount: 2
Activities Information
| Organism | Target Name | Standard Type | Standard Value | Standard Units | doi |
|---|---|---|---|---|---|
| Homo sapiens | 20S proteasome | IC50 | 136.0 | nM | 10.1021/np060162u |
| Homo sapiens | Trypsin | Activity | nan | None | 10.1021/np060162u |
| None | Unchecked | Activity | nan | None | 10.1021/np060162u |