Pyranofoline
AlkaPlorer ID: AK015365
Synonym: None
IUPAC Name: 5,10-dihydroxy-12-methoxy-2,2,11-trimethylpyrano[3,2-b]acridin-6-one
Structure
SMILES: COC1=C2OC(C)(C)C=CC2=C(O)C2=C1N(C)C1=C(O)C=CC=C1C2=O
InChI: InChI=1S/C20H19NO5/c1-20(2)9-8-11-17(24)13-15(19(25-4)18(11)26-20)21(3)14-10(16(13)23)6-5-7-12(14)22/h5-9,22,24H,1-4H3
InChIKey: CTPJHHASTKGQAW-UHFFFAOYSA-N
Reference
Acridone alkaloids as potent inhibitors of cathepsin V
PubChem CID: 9798626
LOTUS: LTS0141666
SuperNatural Ⅲ: SN0055270
COCONUT: CNP0170200
Source
| Species | Genus | Family | Order | Class | Phylum | Kingdom | Domain |
|---|---|---|---|---|---|---|---|
| Glycosmis parviflora | Glycosmis | Rutaceae | Sapindales | Magnoliopsida | Streptophyta | Viridiplantae | Eukaryota |
Properties Information
Molecule Weight: 353.3740000000001
TPSA？: 80.91999999999999
MolLogP？: 3.295700000000002
Number of H-Donors: 2
Number of H-Acceptors: 6
RingCount: 4
Activities Information
| Organism | Target Name | Standard Type | Standard Value | Standard Units | doi |
|---|---|---|---|---|---|
| Homo sapiens | Cathepsin L2 | IC50 | 44000.0 | nM | 10.1016/j.bmc.2010.12.056 |