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name Structure Reference Source Properties Activities Metabolism

Novobiocin

AlkaPlorer ID: AK015982

Synonym: None

IUPAC Name: [(3R,4S,5R,6R)-5-hydroxy-6-[4-hydroxy-3-[[4-hydroxy-3-(3-methylbut-2-enyl)benzoyl]amino]-8-methyl-2-oxochromen-7-yl]oxy-3-methoxy-2,2-dimethyloxan-4-yl] carbamate

Structure

SMILES: CO[C@@H]1[C@@H](OC(=N)O)[C@@H](O)[C@H](OC2=CC=C3C(O)=C(NC(=O)C4=CC=C(O)C(CC=C(C)C)=C4)C(=O)OC3=C2C)OC1(C)C

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InChI: InChI=1S/C31H36N2O11/c1-14(2)7-8-16-13-17(9-11-19(16)34)27(37)33-21-22(35)18-10-12-20(15(3)24(18)42-28(21)38)41-29-23(36)25(43-30(32)39)26(40-6)31(4,5)44-29/h7,9-13,23,25-26,29,34-36H,8H2,1-6H3,(H2,32,39)(H,33,37)/t23-,25+,26-,29-/m1/s1

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InChIKey: YJQPYGGHQPGBLI-KGSXXDOSSA-N

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Properties Information

Molecule Weight: 612.6320000000002

TPSA？: 201.0

MolLogP？: 4.041190000000003

Number of H-Donors: 6

Number of H-Acceptors: 11

RingCount: 4

Activities Information

Organism Target Name Standard Type Standard Value Standard Units doi
Acinetobacter baumannii Acinetobacter baumannii Activity nan None 10.1021/acs.jmedchem.9b00876
Acinetobacter baumannii Acinetobacter baumannii FC 64.0 None 10.1021/acs.jmedchem.9b00876
Acinetobacter baumannii Acinetobacter baumannii FC 256.0 None 10.1021/acs.jmedchem.9b00876
Acinetobacter baumannii Acinetobacter baumannii MIC 0.031 ug.mL-1 10.1021/acs.jmedchem.9b00876
Acinetobacter baumannii Acinetobacter baumannii MIC 16.0 ug.mL-1 10.1021/acs.jmedchem.9b00876
Acinetobacter baumannii Acinetobacter baumannii MIC 40.0 ug.mL-1 10.1128/aac.00748-09
Acinetobacter baumannii Acinetobacter baumannii MIC 84.0 ug.mL-1 10.1128/aac.00748-09
Acinetobacter baumannii Acinetobacter baumannii MIC 120.0 ug.mL-1 10.1128/aac.00748-09
Acinetobacter baumannii Acinetobacter baumannii MIC 128.0 ug.mL-1 10.1021/acs.jmedchem.9b00876
Acinetobacter baumannii Acinetobacter baumannii MIC 2048.0 ug.mL-1 10.1021/acs.jmedchem.9b00876
Acinetobacter baumannii Acinetobacter baumannii MIC nan None 10.1016/j.bmcl.2018.05.049
Acinetobacter baumannii Acinetobacter baumannii Ratio 3.0 None 10.1128/aac.00748-09
Acinetobacter baumannii Acinetobacter baumannii Survival 90.0 % 10.1016/j.bmcl.2022.129113
Acinetobacter baumannii Acinetobacter baumannii Survival 100.0 % 10.1016/j.bmcl.2022.129113
Bacillus subtilis Bacillus subtilis MIC 0.78 ug.mL-1 10.1016/j.bmc.2008.02.006
Bacillus subtilis Bacillus subtilis MIC 0.78 ug.mL-1 10.1016/j.bmc.2008.12.034
Bacillus subtilis Bacillus subtilis MIC 2.0 ug.mL-1 10.1016/j.bmcl.2012.09.071
Bacillus subtilis Bacillus subtilis MIC 16.0 ug.mL-1 10.1021/jf400718w
Candida albicans Candida albicans MIC 32.0 ug.mL-1 10.1016/j.bmcl.2012.09.071
Chlorocebus sabaeus Vero CC50 850.5 ug.mL-1 10.1021/acs.jmedchem.9b00775
Corynebacterium diphtheriae Corynebacterium diphtheriae MIC 1.32 ug.mL-1 10.1016/j.bmc.2018.05.016
Enterobacter cloacae Enterobacter cloacae IZ 0.0 mm 10.1128/aac.00072-07
Enterobacter cloacae Enterobacter cloacae IZ 14.0 mm 10.1128/aac.00072-07
Enterobacter cloacae Enterobacter cloacae IZ 16.0 mm 10.1128/aac.00072-07
Enterobacter cloacae Enterobacter cloacae IZ 20.0 mm 10.1128/aac.00072-07
Enterobacter cloacae Enterobacter cloacae IZ 22.0 mm 10.1128/aac.00072-07
Enterococcus Enterococcus MIC 2.0 ug.mL-1 10.1021/jm200010x
Enterococcus Enterococcus MIC 128.0 ug.mL-1 10.1021/jm200010x
Enterococcus faecalis Enterococcus faecalis MIC 2.0 ug.mL-1 10.1016/j.bmcl.2004.03.044
Enterococcus faecalis Enterococcus faecalis MIC 2.0 ug.mL-1 10.1021/jm030394f
Enterococcus faecalis Enterococcus faecalis MIC 4.0 ug.mL-1 10.1016/j.bmcl.2018.05.049
Enterococcus faecalis Enterococcus faecalis MIC 4.0 ug.mL-1 10.1021/jm0310232
Enterococcus faecalis Enterococcus faecalis MIC 4.0 ug.mL-1 10.1021/jm1014023
Enterococcus faecalis Enterococcus faecalis MIC 8.0 ug.mL-1 10.1016/j.bmcl.2008.11.102
Enterococcus faecalis Enterococcus faecalis MIC 8.0 ug.mL-1 10.1021/acs.jmedchem.6b01834
Enterococcus faecalis Enterococcus faecalis MIC 8.0 ug.mL-1 10.1128/aac.00596-06
Enterococcus faecalis Enterococcus faecalis MIC 16.0 ug.mL-1 10.1128/aac.00596-06
Enterococcus faecalis Enterococcus faecalis MIC 32.0 ug.mL-1 10.1016/j.bmc.2016.04.043
Enterococcus faecalis Enterococcus faecalis MIC 32.0 ug.mL-1 10.1016/j.bmcl.2012.09.071
Enterococcus faecalis Enterococcus faecalis MIC 32.0 ug.mL-1 10.1128/aac.00596-06
Enterococcus faecalis Enterococcus faecalis MIC 32.0 ug.mL-1 10.1128/aac.01235-07
Enterococcus faecalis Enterococcus faecalis MIC50 4.0 ug.mL-1 10.1021/jm0310232
Enterococcus faecalis Enterococcus faecalis MIC90 8.0 ug.mL-1 10.1021/jm0310232
Enterococcus faecium Enterococcus faecium MIC 0.3 ug.mL-1 10.1016/s0960-894x(99)00329-7
Enterococcus faecium Enterococcus faecium MIC 0.3 ug.mL-1 10.1016/s0960-894x(99)00492-8
Enterococcus faecium Enterococcus faecium MIC 0.3 ug.mL-1 10.1016/s0960-894x(99)00493-x
Enterococcus faecium Enterococcus faecium MIC 0.6 ug.mL-1 10.1016/s0960-894x(00)00304-8
Enterococcus faecium Enterococcus faecium MIC 0.6 ug.mL-1 10.1016/s0960-894x(99)00654-x
Enterococcus faecium Enterococcus faecium MIC 2.0 ug.mL-1 10.1021/acs.jmedchem.6b01834
Enterococcus faecium Enterococcus faecium MIC 2.0 ug.mL-1 10.1021/acs.jmedchem.9b00876
Enterococcus faecium Enterococcus faecium MIC 8.0 ug.mL-1 10.1016/j.bmcl.2006.12.065
Enterococcus faecium Enterococcus faecium MIC 8.0 ug.mL-1 10.1016/s0960-894x(00)00109-8
Enterococcus faecium Enterococcus faecium MIC 32.0 ug.mL-1 10.1128/aac.01235-07
Escherichia coli DNA gyrase IC50 0.25 ug.mL-1 10.1016/j.bmcl.2004.03.044
Escherichia coli DNA gyrase IC50 0.25 ug.mL-1 10.1016/s0960-894x(01)00257-8
Escherichia coli DNA gyrase IC50 0.25 ug.mL-1 10.1021/jm030394f
Escherichia coli DNA gyrase IC50 4.52 nM 10.1039/d2md00076h
Escherichia coli DNA gyrase IC50 23.0 nM 10.1016/j.bmc.2016.04.043
Escherichia coli DNA gyrase IC50 23.88 nM 10.1016/j.bmc.2020.115776
Escherichia coli DNA gyrase IC50 80.0 nM 10.1021/acs.jmedchem.5b00489
Escherichia coli DNA gyrase IC50 100.0 nM 10.1128/aac.01551-07
Escherichia coli DNA gyrase IC50 144.0 nM 10.1039/C7MD00012J
Escherichia coli DNA gyrase IC50 168.0 nM 10.1021/acsmedchemlett.0c00416
Escherichia coli DNA gyrase IC50 170.0 nM 10.1016/j.ejmech.2019.02.004
Escherichia coli DNA gyrase IC50 170.0 nM 10.1016/j.ejmech.2021.113200
Escherichia coli DNA gyrase IC50 170.0 nM 10.1021/acs.jmedchem.5b00489
Escherichia coli DNA gyrase IC50 170.0 nM 10.1039/C9MD00224C
Escherichia coli DNA gyrase IC50 245.0 nM 10.1039/C7MD00012J
Escherichia coli DNA gyrase IC50 500.0 nM 10.1016/j.bmc.2016.04.043
Escherichia coli DNA gyrase Inhibition nan % 10.1039/C8MD00148K
Escherichia coli DNA gyrase MNEC 0.1 ug ml-1 10.1021/jm0310232
Escherichia coli DNA gyrase MNEC 0.25 ug ml-1 10.1016/s0960-894x(00)00109-8
Escherichia coli DNA gyrase Ratio 1.0 None 10.1016/s0960-894x(99)00329-7
Escherichia coli DNA gyrase subunit B Activity 50.0 % 10.1016/j.ejmech.2018.05.011
Escherichia coli DNA gyrase subunit B Delta Tm 11.5 degrees C 10.1039/C8MD00148K
Escherichia coli DNA gyrase subunit B IC50 154.0 nM 10.1128/aac.01235-07
Escherichia coli DNA gyrase subunit B IC50 170.0 nM 10.1016/j.ejmech.2016.09.040
Escherichia coli DNA gyrase subunit B IC50 170.0 nM 10.1016/j.ejmech.2018.05.011
Escherichia coli DNA gyrase subunit B IC50 170.0 nM 10.1021/acs.jmedchem.6b00864
Escherichia coli DNA gyrase subunit B IC50 200.0 nM 10.1128/aac.01235-07
Escherichia coli DNA gyrase subunit B Kd 7.0 nM 10.1016/j.ejmech.2016.08.034
Escherichia coli DNA gyrase subunit B Kd 28.0 nM 10.1021/jm101121s
Escherichia coli DNA gyrase subunit B Ki 7.0 nM 10.1016/j.ejmech.2016.08.034
Escherichia coli DNA gyrase subunit B Ratio 1.0 None 10.1016/s0960-894x(99)00493-x
Escherichia coli DNA gyrase subunit B Ratio IC50 0.8 None 10.1128/aac.01235-07
Escherichia coli DNA repair protein RecN FC 14.0 None 10.1021/acs.jmedchem.0c00328
Escherichia coli Escherichia coli Activity 2.0 None 10.1128/aac.01481-06
Escherichia coli Escherichia coli Activity 9.5 % 10.1128/aac.01481-06
Escherichia coli Escherichia coli Activity 17.0 % 10.1128/aac.01481-06
Escherichia coli Escherichia coli Activity 20.0 % 10.1128/aac.01481-06
Escherichia coli Escherichia coli Activity 21.2 % 10.1128/aac.01481-06
Escherichia coli Escherichia coli Activity 21.3 % 10.1128/aac.01481-06
Escherichia coli Escherichia coli Activity 23.6 % 10.1128/aac.01481-06
Escherichia coli Escherichia coli Activity 24.5 % 10.1128/aac.01481-06
Escherichia coli Escherichia coli Activity 25.3 % 10.1128/aac.01481-06
Escherichia coli Escherichia coli Activity 25.5 % 10.1128/aac.01481-06
Escherichia coli Escherichia coli Activity 25.7 % 10.1128/aac.01481-06
Escherichia coli Escherichia coli Activity 26.9 % 10.1128/aac.01481-06
Escherichia coli Escherichia coli Activity 28.4 % 10.1128/aac.01481-06
Escherichia coli Escherichia coli Activity 28.6 % 10.1128/aac.01481-06
Escherichia coli Escherichia coli Activity 32.6 % 10.1128/aac.01481-06
Escherichia coli Escherichia coli Activity 36.0 % 10.1128/aac.01481-06
Escherichia coli Escherichia coli Activity 36.5 % 10.1128/aac.01481-06
Escherichia coli Escherichia coli Activity 38.4 % 10.1128/aac.01481-06
Escherichia coli Escherichia coli Activity 39.8 % 10.1128/aac.01481-06
Escherichia coli Escherichia coli Activity 45.3 % 10.1128/aac.01481-06
Escherichia coli Escherichia coli Activity 46.8 % 10.1128/aac.01481-06
Escherichia coli Escherichia coli Activity 48.5 % 10.1128/aac.01481-06
Escherichia coli Escherichia coli Activity 50.9 % 10.1128/aac.01481-06
Escherichia coli Escherichia coli Activity 55.2 % 10.1128/aac.01481-06
Escherichia coli Escherichia coli Activity nan None 10.1021/acs.jmedchem.9b00876
Escherichia coli Escherichia coli Activity nan None 10.1039/C1MD00081K
Escherichia coli Escherichia coli Activity nan None 10.1039/C7MD00012J
Escherichia coli Escherichia coli Activity nan None 10.1128/aac.01481-06
Escherichia coli Escherichia coli Activity nan None 10.1128/aac.01677-09
Escherichia coli Escherichia coli IZ 7.0 mm 10.1016/j.bmc.2016.01.041
Escherichia coli Escherichia coli IZ 9.0 mm 10.1021/jm060492b
Escherichia coli Escherichia coli IZ 15.0 mm 10.1021/jm060492b
Escherichia coli Escherichia coli MIC 0.4 ug.mL-1 10.1039/C7MD00012J
Escherichia coli Escherichia coli MIC 0.5 ug.mL-1 10.1021/jm030394f
Escherichia coli Escherichia coli MIC 0.5 ug.mL-1 10.1021/jm301499r
Escherichia coli Escherichia coli MIC 0.5 ug.mL-1 10.1128/aac.00748-09
Escherichia coli Escherichia coli MIC 0.8 ug.mL-1 10.1039/C7MD00012J
Escherichia coli Escherichia coli MIC 1.0 ug.mL-1 10.1128/aac.00719-10
Escherichia coli Escherichia coli MIC 1.56 ug.mL-1 10.1128/aac.00475-08
Escherichia coli Escherichia coli MIC 2.0 ug.mL-1 10.1016/j.bmcl.2012.09.071
Escherichia coli Escherichia coli MIC 2.0 ug.mL-1 10.1021/acs.jmedchem.6b01834
Escherichia coli Escherichia coli MIC 2.0 ug.mL-1 10.1128/aac.01677-09
Escherichia coli Escherichia coli MIC 3.125 ug.mL-1 10.1016/j.bmc.2008.02.006
Escherichia coli Escherichia coli MIC 3.125 ug.mL-1 10.1016/j.bmc.2008.12.034
Escherichia coli Escherichia coli MIC 3.125 ug.mL-1 10.1128/aac.00475-08
Escherichia coli Escherichia coli MIC 3.2 ug.mL-1 10.1039/C7MD00012J
Escherichia coli Escherichia coli MIC 4.0 ug.mL-1 10.1016/j.bmcl.2011.08.035
Escherichia coli Escherichia coli MIC 4.0 ug.mL-1 10.1016/j.ejmech.2018.07.059
Escherichia coli Escherichia coli MIC 4.0 ug.mL-1 10.1128/aac.00748-09
Escherichia coli Escherichia coli MIC 4.0 ug.mL-1 10.1128/aac.00921-08
Escherichia coli Escherichia coli MIC 4.0 ug.mL-1 10.1128/aac.01048-06
Escherichia coli Escherichia coli MIC 4.0 ug.mL-1 10.1128/aac.01126-09
Escherichia coli Escherichia coli MIC 4.0 ug.mL-1 10.1128/aac.01235-07
Escherichia coli Escherichia coli MIC 4.0 ug.mL-1 10.1128/aac.01677-09
Escherichia coli Escherichia coli MIC 4.94 ug.mL-1 10.1016/j.bmc.2018.05.016
Escherichia coli Escherichia coli MIC 6.3 ug.mL-1 10.1039/C7MD00012J
Escherichia coli Escherichia coli MIC 6.4 ug.mL-1 10.1039/C7MD00012J
Escherichia coli Escherichia coli MIC 8.0 ug.mL-1 10.1016/j.bmcl.2008.11.102
Escherichia coli Escherichia coli MIC 8.0 ug.mL-1 10.1016/j.bmcl.2010.02.060
Escherichia coli Escherichia coli MIC 8.0 ug.mL-1 10.1021/jm200010x
Escherichia coli Escherichia coli MIC 8.0 ug.mL-1 10.1128/aac.01126-09
Escherichia coli Escherichia coli MIC 8.0 ug.mL-1 10.1128/aac.01677-09
Escherichia coli Escherichia coli MIC 12.8 ug.mL-1 10.1039/C7MD00012J
Escherichia coli Escherichia coli MIC 16.0 ug.mL-1 10.1021/acs.jmedchem.6b01834
Escherichia coli Escherichia coli MIC 16.0 ug.mL-1 10.1128/aac.01677-09
Escherichia coli Escherichia coli MIC 20.0 ug.mL-1 10.1128/aac.00748-09
Escherichia coli Escherichia coli MIC 32.0 ug.mL-1 10.1016/j.bmc.2016.04.043
Escherichia coli Escherichia coli MIC 32.0 ug.mL-1 10.1016/j.bmcl.2012.09.071
Escherichia coli Escherichia coli MIC 32.0 ug.mL-1 10.1016/j.ejmech.2012.03.008
Escherichia coli Escherichia coli MIC 32.0 ug.mL-1 10.1021/jm301499r
Escherichia coli Escherichia coli MIC 32.0 ug.mL-1 10.1128/aac.00719-10
Escherichia coli Escherichia coli MIC 32.0 ug.mL-1 10.1128/aac.01235-07
Escherichia coli Escherichia coli MIC 40.0 ug.mL-1 10.1128/aac.01168-09
Escherichia coli Escherichia coli MIC 64.0 ug.mL-1 10.1016/j.bmc.2020.115776
Escherichia coli Escherichia coli MIC 64.0 ug.mL-1 10.1016/j.bmcl.2018.05.049
Escherichia coli Escherichia coli MIC 64.0 ug.mL-1 10.1021/jm030394f
Escherichia coli Escherichia coli MIC 64.0 ug.mL-1 10.1021/jm0310232
Escherichia coli Escherichia coli MIC 64.0 ug.mL-1 10.1021/jm1014023
Escherichia coli Escherichia coli MIC 64.0 ug.mL-1 10.1128/aac.00719-10
Escherichia coli Escherichia coli MIC 100.0 ug.mL-1 10.1039/C7MD00012J
Escherichia coli Escherichia coli MIC 102.0 ug.mL-1 10.1039/C7MD00012J
Escherichia coli Escherichia coli MIC 125.0 nM 10.1016/j.bmcl.2023.129301
Escherichia coli Escherichia coli MIC 125.0 ug.mL-1 10.1021/jm0000057
Escherichia coli Escherichia coli MIC 128.0 ug.mL-1 10.1016/j.bmcl.2010.01.040
Escherichia coli Escherichia coli MIC 128.0 ug.mL-1 10.1039/d2md00041e
Escherichia coli Escherichia coli MIC 256.0 ug.mL-1 10.1128/aac.00719-10
Escherichia coli Escherichia coli MIC 500.0 ug.mL-1 10.1128/aac.01168-09
Escherichia coli Escherichia coli MIC 512.0 ug.mL-1 10.1128/aac.00921-08
Escherichia coli Escherichia coli MIC 512.0 ug.mL-1 10.1128/aac.01048-06
Escherichia coli Escherichia coli MIC 512.0 ug.mL-1 10.1128/aac.01126-09
Escherichia coli Escherichia coli MIC 512.0 ug.mL-1 10.1128/aac.01472-06
Escherichia coli Escherichia coli MIC 1000.0 nM 10.1016/j.bmcl.2023.129301
Escherichia coli Escherichia coli MIC 1024.0 ug.mL-1 10.1128/aac.00921-08
Escherichia coli Escherichia coli MIC 1024.0 ug.mL-1 10.1128/aac.01472-06
Escherichia coli Escherichia coli MIC 1200.0 nM 10.1021/acsmedchemlett.5b00024
Escherichia coli Escherichia coli MIC 64000.0 nM 10.1016/j.bmcl.2023.129301
Escherichia coli Escherichia coli MIC 256000.0 nM 10.1016/j.bmcl.2023.129301
Escherichia coli Escherichia coli MIC 320000.0 nM 10.1021/acsmedchemlett.5b00024
Escherichia coli Escherichia coli MIC nan None 10.1016/j.bmc.2020.115776
Escherichia coli Escherichia coli MIC80 0.1 ug.mL-1 10.1021/np401094h
Escherichia coli Escherichia coli MIC80 0.3 ug.mL-1 10.1021/np401094h
Escherichia coli Escherichia coli Ratio 4.0 None 10.1128/aac.00921-08
Escherichia coli Escherichia coli Ratio 5.0 None 10.1128/aac.00748-09
Escherichia coli Escherichia coli Ratio 32.0 None 10.1016/j.ejmech.2012.03.008
Escherichia coli Escherichia coli Ratio 64.0 None 10.1016/j.ejmech.2012.03.008
Escherichia coli LexA repressor FC 5.0 None 10.1021/acs.jmedchem.0c00328
Escherichia coli K-12 Cell division inhibitor sulA Activity 6.3 uM 10.1128/aac.01235-07
Escherichia coli K-12 Cell division inhibitor sulA FC 17.0 None 10.1021/acs.jmedchem.0c00328
Escherichia coli K-12 DNA gyrase subunit A Activity 3.1 uM 10.1128/aac.01235-07
Escherichia coli K-12 Recombinase A FC 20.0 None 10.1021/acs.jmedchem.0c00328
Haemophilus influenzae Haemophilus influenzae MIC 0.063 ug.mL-1 10.1021/jm800318d
Haemophilus influenzae Haemophilus influenzae MIC 0.064 ug.mL-1 10.1128/aac.00596-06
Haemophilus influenzae Haemophilus influenzae MIC 0.12 ug.mL-1 10.1016/j.bmc.2016.04.043
Haemophilus influenzae Haemophilus influenzae MIC 0.12 ug.mL-1 10.1016/j.bmcl.2012.09.071
Haemophilus influenzae Haemophilus influenzae MIC 0.125 ug.mL-1 10.1021/acs.jmedchem.6b01834
Haemophilus influenzae Haemophilus influenzae MIC 0.25 ug.mL-1 10.1128/aac.00596-06
Haemophilus influenzae Haemophilus influenzae MIC 0.5 ug.mL-1 10.1016/j.bmcl.2018.05.049
Haemophilus influenzae Haemophilus influenzae MIC 4.0 ug.mL-1 10.1128/aac.00596-06
Haemophilus influenzae Haemophilus influenzae MIC 8.0 ug.mL-1 10.1128/aac.00596-06
Homo sapiens Acetylcholinesterase AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Adenosine A1 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Adenosine A2a receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Adenosine A3 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens AGS Activity 63.0 % 10.1021/np8004248
Homo sapiens AGS Activity 72.0 % 10.1021/np8004248
Homo sapiens Alpha-1a adrenergic receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-2a adrenergic receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-2b adrenergic receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-2c adrenergic receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Angiotensin-converting enzyme Inhibition 75.0 % 10.1021/jm400813y
Homo sapiens Angiotensin-converting enzyme Inhibition nan % 10.1021/jm400813y
Homo sapiens Angiotensin-converting enzyme Ki 167000.0 nM 10.1021/jm400813y
Homo sapiens ATP-binding cassette sub-family G member 2 Activity 3.0 fold 10.1016/j.placenta.2005.11.012
Homo sapiens ATP-binding cassette sub-family G member 2 IC50 25000.0 nM 10.1016/j.placenta.2005.11.012
Homo sapiens ATP-binding cassette sub-family G member 2 IC50 26800.0 nM 10.1016/j.ejmech.2022.114346
Homo sapiens ATP-binding cassette sub-family G member 2 IC50 66069.34 nM 10.1016/j.bmc.2008.07.034
Homo sapiens ATP-binding cassette sub-family G member 2 IC50 85100.0 nM 10.1016/j.bmcl.2009.11.004
Homo sapiens ATP-binding cassette sub-family G member 2 IC50 104000.0 nM 10.1016/j.bmcl.2009.11.004
Homo sapiens ATP-binding cassette sub-family G member 2 Ki nan None 10.1002/ijc.11528
Homo sapiens Beta-1 adrenergic receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Beta-2 adrenergic receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Bile salt export pump AC50 219998.6 nM 10.1038/s41467-023-40064-9
Homo sapiens Cannabinoid CB1 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Cholecystokinin A receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Cyclooxygenase-2 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Delta opioid receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens DNA-(apurinic or apyrimidinic site) lyase Potency 10.0 nM None
Homo sapiens DNA topoisomerase II IC50 400.0 ug.mL-1 10.1016/j.bmcl.2004.03.044
Homo sapiens DNA topoisomerase II alpha IC50 256000.0 nM 10.1021/acs.jmedchem.6b01834
Homo sapiens DNA topoisomerase II alpha IC50 nan None 10.1021/acs.jmedchem.8b01750
Homo sapiens DNA topoisomerase II alpha Inhibition 14.4 % 10.1016/j.ejmech.2013.07.048
Homo sapiens DNA topoisomerase II alpha Inhibition 22.7 % 10.1016/j.ejmech.2016.09.019
Homo sapiens DNA topoisomerase II alpha Inhibition 33.3 % 10.1016/j.ejmech.2016.09.019
Homo sapiens DNA topoisomerase II alpha Inhibition 55.9 % 10.1016/j.ejmech.2016.09.019
Homo sapiens DNA topoisomerase II alpha Inhibition 60.4 % 10.1016/j.ejmech.2011.01.011
Homo sapiens DNA topoisomerase II alpha Inhibition 63.6 % 10.1016/j.ejmech.2013.07.048
Homo sapiens DNA topoisomerase II alpha Inhibition 76.8 % 10.1016/j.ejmech.2013.07.048
Homo sapiens DNA topoisomerase II beta Ratio 1.0 None 10.1016/s0960-894x(99)00492-8
Homo sapiens Dopamine D1 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine D2 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine D3 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine transporter AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Endothelin receptor ET-A AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Epidermal growth factor receptor erbB1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Equilibrative nucleoside transporter 1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Estrogen receptor alpha AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Gamma-aminobutyric acid receptor-associated protein Activity nan None 10.1021/acs.jmedchem.0c01564
Homo sapiens Gamma-aminobutyric acid receptor-associated protein-like 1 Activity nan None 10.1021/acs.jmedchem.0c01564
Homo sapiens Gamma-aminobutyric acid receptor-associated protein-like 2 Activity nan None 10.1021/acs.jmedchem.0c01564
Homo sapiens Gamma-aminobutyric acid receptor subunit alpha-1/alpha-2/beta-2/gamma-2 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Ghrelin receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Glucocorticoid receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Heat shock protein HSP90 EC50 700000.0 nM 10.1021/acsmedchemlett.0c00100
Homo sapiens Heat shock protein HSP90 IC50 700000.0 nM 10.1016/j.ejmech.2020.112063
Homo sapiens Heat shock protein HSP90 Inhibition nan % 10.1016/j.bmc.2013.06.042
Homo sapiens Heat shock protein HSP90 Kd 500000.0 nM 10.1039/d0md00387e
Homo sapiens Heat shock protein HSP 90-alpha Activity nan None 10.1016/j.bmc.2010.10.029
Homo sapiens Heat shock protein HSP 90-alpha Inhibition nan % 10.1016/j.bmcl.2021.128134
Homo sapiens Heat shock protein HSP 90-beta Activity 700.0 uM 10.1021/ml100070r
Homo sapiens Heat shock protein HSP 90-beta Activity nan None 10.1016/j.bmc.2010.10.029
Homo sapiens Heat shock protein HSP 90-beta IC50 231000.0 nM 10.1016/j.bmc.2014.06.006
Homo sapiens Heat shock protein HSP 90-beta Inhibition nan % 10.1021/acs.jmedchem.7b01395
Homo sapiens HEK293 Inhibition nan % 10.1016/j.bmc.2014.09.008
Homo sapiens HepG2 IC50 32.0 ug.mL-1 10.1016/j.bmcl.2018.05.049
Homo sapiens Histamine H1 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Histamine H3 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Histone deacetylase 6 Inhibition -65.57 % 10.6019/CHEMBL4808148
Homo sapiens Histone deacetylase 6 Inhibition 0.77 % 10.6019/CHEMBL4808148
Homo sapiens Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 Potency 19952.6 nM None
Homo sapiens Hsp90 co-chaperone Cdc37 Activity nan None 10.1021/np200029q
Homo sapiens Huh-7 CC50 1103.18 ug.mL-1 10.1021/acs.jmedchem.9b00775
Homo sapiens Jurkat Activity 700.0 uM 10.1016/j.bmcl.2011.09.096
Homo sapiens LNCaP IC50 420000.0 nM 10.1016/j.bmc.2010.10.029
Homo sapiens MCF7 Activity 5.9 % 10.1021/jm0707774
Homo sapiens MCF7 Activity 9.8 % 10.1021/jm0707774
Homo sapiens MCF7 Activity 19.3 % 10.1021/jm0707774
Homo sapiens MCF7 Activity 19.7 % 10.1021/jm0707774
Homo sapiens MCF7 Activity 21.3 % 10.1021/jm0707774
Homo sapiens MCF7 Activity 58.3 % 10.1021/jm0707774
Homo sapiens MCF7 Activity 59.9 % 10.1021/jm0707774
Homo sapiens MCF7 Activity nan None 10.1016/j.ejmech.2014.06.067
Homo sapiens MCF7 Activity nan None 10.1021/jm0707774
Homo sapiens MCF7 GI50 260000.0 nM 10.1016/j.ejmech.2014.06.067
Homo sapiens MCF7 IC50 256000.0 nM 10.1021/acs.jmedchem.9b00940
Homo sapiens MCF7 IC50 260000.0 nM 10.1016/j.ejmech.2014.06.067
Homo sapiens MCF7 IC50 260000.0 nM 10.1016/j.ejmech.2021.114052
Homo sapiens MCF7 IC50 260000.0 nM 10.1021/jm0707774
Homo sapiens MCF7 IC50 293300.0 nM 10.1016/j.ejmech.2016.04.050
Homo sapiens MCF7 IC50 357000.0 nM 10.1016/j.bmc.2013.06.042
Homo sapiens MCF7 IC50 481300.0 nM 10.1016/j.bmcl.2010.04.140
Homo sapiens MCF7 IC50 nan None 10.1016/j.ejmech.2014.10.034
Homo sapiens MDA-MB-468 IC50 338400.0 nM 10.1016/j.ejmech.2016.04.050
Homo sapiens Melanocortin receptor 3 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Microtubule-associated proteins 1A/1B light chain 3A Activity nan None 10.1021/acs.jmedchem.0c01564
Homo sapiens Microtubule-associated proteins 1A/1B light chain 3A Delta Tm 4.4 degrees C 10.1021/acs.jmedchem.0c01564
Homo sapiens Microtubule-associated proteins 1A/1B light chain 3A IC50 42900.0 nM 10.1021/acs.jmedchem.0c01564
Homo sapiens Microtubule-associated proteins 1A/1B light chain 3A Kd 7500.0 nM 10.1021/acs.jmedchem.0c01564
Homo sapiens Microtubule-associated proteins 1A/1B light chain 3A Ki 8800.0 nM 10.1021/acs.jmedchem.0c01564
Homo sapiens Microtubule-associated proteins 1A/1B light chain 3B Activity nan None 10.1021/acs.jmedchem.0c01564
Homo sapiens Microtubule-associated proteins 1A/1B light chain 3B Delta Tm 4.4 degrees C 10.1021/acs.jmedchem.0c01564
Homo sapiens Microtubule-associated proteins 1A/1B light chain 3B IC50 172000.0 nM 10.1021/acs.jmedchem.0c01564
Homo sapiens Microtubule-associated proteins 1A/1B light chain 3B Kd 17400.0 nM 10.1021/acs.jmedchem.0c01564
Homo sapiens Microtubule-associated proteins 1A/1B light chain 3B Ki 19300.0 nM 10.1021/acs.jmedchem.0c01564
Homo sapiens Microtubule-associated proteins 1A/1B light chain 3C Activity nan None 10.1021/acs.jmedchem.0c01564
Homo sapiens Monoamine oxidase A AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Motilin receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Mu opioid receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Muscarinic acetylcholine receptor M1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Muscarinic acetylcholine receptor M2 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Muscarinic acetylcholine receptor M3 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Neuronal acetylcholine receptor protein alpha-4 subunit AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Norepinephrine transporter AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Peroxisome proliferator-activated receptor gamma AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens P-glycoprotein 1 Activity nan None 10.1016/j.bmc.2008.07.034
Homo sapiens Phosphodiesterase 3A AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Phosphodiesterase 4D AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Pregnane X receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Progesterone receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Receptor protein-tyrosine kinase erbB-2 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 1a (5-HT1a) receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2a (5-HT2a) receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2b (5-HT2b) receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2c (5-HT2c) receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 3a (5-HT3a) receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin transporter AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serum albumin Kd 12000.0 nM 10.1128/aac.00971-08
Homo sapiens Serum albumin Log K' 0.35 None 10.1021/jm010960b
Homo sapiens Serum albumin Ratio 0.5 None 10.1128/aac.00971-08
Homo sapiens Serum albumin Ratio 1.0 None 10.1128/aac.00971-08
Homo sapiens Serum albumin Ratio 1.5 None 10.1128/aac.00971-08
Homo sapiens Serum albumin Ratio 2.0 None 10.1128/aac.00971-08
Homo sapiens SH-SY5Y Activity nan None 10.1016/j.bmc.2008.12.047
Homo sapiens SH-SY5Y EC50 48.39 nM 10.1016/j.bmc.2008.12.047
Homo sapiens SK-BR-3 Activity 10.0 % 10.1016/j.bmc.2013.06.042
Homo sapiens SK-BR-3 Activity 15.0 % 10.1016/j.bmc.2013.06.042
Homo sapiens SK-BR-3 Activity 38.0 % 10.1016/j.bmc.2013.06.042
Homo sapiens SK-BR-3 Activity 57.0 % 10.1016/j.bmc.2013.06.042
Homo sapiens SK-BR-3 EC50 700000.0 nM 10.1016/j.bmc.2018.04.028
Homo sapiens SK-BR-3 IC50 350000.0 nM 10.1016/j.bmc.2013.06.042
Homo sapiens SK-BR-3 IC50 474700.0 nM 10.1016/j.bmcl.2010.04.140
Homo sapiens SK-BR-3 IC50 700000.0 nM 10.1016/j.bmc.2009.10.061
Homo sapiens SK-BR-3 IC50 700000.0 nM 10.1016/j.bmcl.2012.11.022
Homo sapiens SK-BR-3 IC50 700000.0 nM 10.1021/acs.jmedchem.8b00825
Homo sapiens SK-BR-3 IC50 700000.0 nM 10.1021/jm200148p
Homo sapiens SK-BR-3 IC50 700000.0 nM 10.1021/ml300275g
Homo sapiens Sodium channel protein type V alpha subunit AC50 50000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Solute carrier family 22 member 6 Activity nan None 10.1038/nrd3028
Homo sapiens Solute carrier family 22 member 8 Activity nan None 10.1038/nrd3028
Homo sapiens Solute carrier organic anion transporter family member 1B1 Inhibition 58.1 % 10.1021/jm300212s
Homo sapiens Solute carrier organic anion transporter family member 1B3 Inhibition 84.2 % 10.1021/jm300212s
Homo sapiens Solute carrier organic anion transporter family member 2B1 Inhibition 85.6 % 10.1021/jm300212s
Homo sapiens Thromboxane A2 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Type-1 angiotensin II receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens UDP-glucuronosyltransferase 1-1 Activity 0.0 pm/min/mg 10.1146/annurev.pharmtox.40.1.581
Homo sapiens Vascular endothelial growth factor receptor 2 AC50 25000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Vasopressin V1a receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Klebsiella aerogenes Klebsiella aerogenes Activity nan None 10.1128/aac.01481-06
Klebsiella pneumoniae Klebsiella pneumoniae Activity -1.87 CFU/ml 10.1021/acs.jmedchem.9b00876
Klebsiella pneumoniae Klebsiella pneumoniae Activity nan None 10.1128/aac.00657-08
Klebsiella pneumoniae Klebsiella pneumoniae IZ 9.0 mm 10.1128/aac.00657-08
Klebsiella pneumoniae Klebsiella pneumoniae MIC 0.5 ug.mL-1 10.1016/j.bmc.2018.05.016
Klebsiella pneumoniae Klebsiella pneumoniae MIC 32.0 ug.mL-1 10.1128/aac.01235-07
Klebsiella pneumoniae Klebsiella pneumoniae MIC 62.0 ug.mL-1 10.1021/jm0000057
Klebsiella pneumoniae Klebsiella pneumoniae MIC 250.0 ug.mL-1 10.1021/jm0000057
Listeria monocytogenes Listeria monocytogenes MIC 0.25 ug.mL-1 10.1016/j.ejmech.2018.07.059
Moraxella catarrhalis Moraxella catarrhalis MIC 1.0 ug.mL-1 10.1021/acs.jmedchem.6b01834
Moraxella catarrhalis Moraxella catarrhalis MIC 32.0 ug.mL-1 10.1016/j.bmc.2016.04.043
Mus musculus Monoamine oxidase A Activity nan None 10.1021/jm800656v
Mus musculus Mus musculus AUC/dose nan None 10.1021/acsmedchemlett.5b00266
Mus musculus Mus musculus CL nan None 10.1021/acsmedchemlett.5b00266
Mus musculus Mus musculus Inhibition 7.56 % 10.1016/j.ejmech.2016.08.034
Mus musculus Mus musculus Inhibition nan % 10.1016/j.ejmech.2016.08.034
Mus musculus Mus musculus t1/2 nan None 10.1021/acsmedchemlett.5b00266
Mus musculus Mus musculus Vdss nan None 10.1021/acsmedchemlett.5b00266
Mus musculus N2a Activity nan None 10.1016/j.bmc.2022.116940
Mus musculus RAW264.7 GI nan None 10.1016/j.bmc.2015.03.004
Mus musculus RAW264.7 Inhibition 19.3 % 10.1016/j.bmc.2015.11.039
Mus musculus RAW264.7 Inhibition 19.36 % 10.1016/j.bmc.2014.06.041
Mus musculus RAW264.7 Inhibition 29.44 % 10.1016/j.ejmech.2014.08.018
Mus musculus RAW264.7 Inhibition 81.67 % 10.1016/j.bmc.2015.02.032
Mus musculus RAW264.7 Inhibition nan % 10.1016/j.bmc.2014.10.016
Mus musculus RAW264.7 Inhibition nan % 10.1016/j.bmc.2016.01.011
Mus musculus RAW264.7 Inhibition nan % 10.1016/j.ejmech.2015.06.032
Mycobacterium leprae Mycobacterium leprae CC25 nan None 10.1128/aac.01095-07
Mycobacterium leprae Mycobacterium leprae IC50 0.2 ug.mL-1 10.1128/aac.01095-07
Mycobacterium leprae Mycobacterium leprae IC50 0.25 ug.mL-1 10.1128/aac.01095-07
Mycobacterium leprae Mycobacterium leprae IC50 0.3 ug.mL-1 10.1128/aac.01095-07
Mycobacterium smegmatis DNA gyrase subunit B IC50 46.0 nM 10.1016/j.bmc.2015.02.032
Mycobacterium smegmatis DNA gyrase subunit B IC50 180.0 nM 10.1016/j.bmc.2014.06.041
Mycobacterium smegmatis DNA gyrase subunit B IC50 180.0 nM 10.1016/j.bmc.2014.10.016
Mycobacterium smegmatis DNA gyrase subunit B IC50 180.0 nM 10.1016/j.bmc.2015.03.004
Mycobacterium smegmatis DNA gyrase subunit B IC50 180.0 nM 10.1016/j.ejmech.2015.06.032
Mycobacterium smegmatis DNA gyrase subunit B IC50 200.0 nM 10.1016/j.ejmech.2013.09.025
Mycobacterium smegmatis DNA gyrase subunit B IC50 180000.0 nM 10.1016/j.ejmech.2016.08.034
Mycobacterium smegmatis DNA gyrase subunit B Inhibition 96.0 % 10.1016/j.ejmech.2013.09.025
Mycobacterium smegmatis DNA gyrase subunit B Inhibition 98.2 % 10.1016/j.ejmech.2013.09.025
Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155) DNA gyrase subunit B IC50 46.0 nM 10.1016/j.ejmech.2016.06.042
Mycobacterium tuberculosis Mycobacterium tuberculosis FC 2.0 None 10.1128/aac.00550-09
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 4.0 ug.mL-1 10.1016/j.bmcl.2011.08.035
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 4.0 ug.mL-1 10.1016/j.bmcl.2018.05.049
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 4.0 ug.mL-1 10.1128/aac.00550-09
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 6.7 ug.mL-1 10.1016/j.bmcl.2018.05.049
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 7.35 ug.mL-1 10.1016/j.bmcl.2018.05.049
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 8.0 ug.mL-1 10.1128/aac.00550-09
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 13.5 ug.mL-1 10.1016/j.bmcl.2018.05.049
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 16.0 ug.mL-1 10.1128/aac.00550-09
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 50000.0 nM 10.1016/j.bmc.2016.01.011
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 200000.0 nM 10.1016/j.bmc.2014.06.041
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 200000.0 nM 10.1016/j.bmc.2015.03.004
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 200000.0 nM 10.1016/j.bmc.2015.11.039
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 200000.0 nM 10.1016/j.ejmech.2013.09.025
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 200000.0 nM 10.1016/j.ejmech.2014.08.018
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 200000.0 nM 10.1016/j.ejmech.2015.06.032
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 200000.0 nM 10.1016/j.ejmech.2016.08.034
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC nan None 10.1016/j.bmc.2014.10.016
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC nan None 10.1016/j.bmc.2015.02.032
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC nan None 10.1016/j.ejmech.2016.06.042
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC nan None 10.1128/aac.00550-09
Mycobacterium tuberculosis Mycobacterium tuberculosis Ratio 4.0 None 10.1128/aac.00550-09
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) DNA gyrase subunit A/DNA gyrase subunit B IC50 15.0 nM 10.1021/ml5001933
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) DNA gyrase subunit A/DNA gyrase subunit B IC50 20.0 nM 10.1016/j.bmcl.2018.05.049
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) DNA gyrase subunit A/DNA gyrase subunit B IC50 46.0 nM 10.1016/j.bmc.2014.06.041
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) DNA gyrase subunit A/DNA gyrase subunit B IC50 46.0 nM 10.1016/j.bmc.2014.10.016
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) DNA gyrase subunit A/DNA gyrase subunit B IC50 46.0 nM 10.1016/j.bmc.2015.03.004
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) DNA gyrase subunit A/DNA gyrase subunit B IC50 46.0 nM 10.1016/j.bmc.2016.01.011
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) DNA gyrase subunit A/DNA gyrase subunit B IC50 46.0 nM 10.1016/j.ejmech.2015.06.032
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) DNA gyrase subunit A/DNA gyrase subunit B IC50 46.0 nM 10.1016/j.ejmech.2016.08.034
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) DNA gyrase subunit A/DNA gyrase subunit B IC50 50.0 nM 10.1016/j.ejmech.2013.09.025
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) DNA gyrase subunit A/DNA gyrase subunit B IC50 85.0 nM 10.1016/j.bmcl.2018.05.049
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) DNA gyrase subunit A/DNA gyrase subunit B IC50 46000.0 nM 10.1016/j.bmc.2015.11.039
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) DNA gyrase subunit A/DNA gyrase subunit B Inhibition 100.0 % 10.1016/j.bmcl.2017.02.031
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) DNA gyrase subunit A/DNA gyrase subunit B Inhibition 100.0 % 10.1016/j.ejmech.2013.09.025
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) DNA gyrase subunit A/DNA gyrase subunit B Inhibition 100.0 % 10.1016/j.ejmech.2020.112326
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) DNA gyrase subunit A/DNA gyrase subunit B Inhibition nan % 10.1016/j.ejmech.2013.09.025
Mycobacterium tuberculosis variant bovis BCG Mycobacterium tuberculosis variant bovis BCG MIC 0.5 ug.mL-1 10.1128/aac.00550-09
Mycobacterium tuberculosis variant bovis BCG Mycobacterium tuberculosis variant bovis BCG MIC 1.0 ug.mL-1 10.1128/aac.00550-09
Mycobacterium tuberculosis variant bovis BCG Mycobacterium tuberculosis variant bovis BCG MIC 2.0 ug.mL-1 10.1128/aac.00550-09
Mycobacterium tuberculosis variant bovis BCG Mycobacterium tuberculosis variant bovis BCG MIC 4.0 ug.mL-1 10.1128/aac.00550-09
Mycobacterium tuberculosis variant bovis BCG Mycobacterium tuberculosis variant bovis BCG MIC 8.0 ug.mL-1 10.1128/aac.00550-09
Mycobacterium tuberculosis variant bovis BCG Mycobacterium tuberculosis variant bovis BCG MIC 16.0 ug.mL-1 10.1128/aac.00550-09
Mycolicibacterium smegmatis Mycolicibacterium smegmatis MIC 1.0 ug.mL-1 10.1016/j.bmcl.2018.05.049
Mycolicibacterium smegmatis Mycolicibacterium smegmatis MIC 4.0 ug.mL-1 10.1128/aac.00298-08
Mycolicibacterium smegmatis Mycolicibacterium smegmatis MIC 8.0 ug.mL-1 10.1128/aac.00298-08
Mycolicibacterium smegmatis Mycolicibacterium smegmatis Ratio 2.0 None 10.1128/aac.00298-08
Oryctolagus cuniculus Heat shock protein HSP 90 Activity nan None 10.1016/j.bmc.2010.10.029
Oryctolagus cuniculus Heat shock protein HSP 90 IC50 350000.0 nM 10.1016/j.bmcl.2010.12.088
Oryctolagus cuniculus Heat shock protein HSP 90 IC50 414000.0 nM 10.1016/j.bmc.2014.06.006
Oryctolagus cuniculus Heat shock protein HSP 90 Inhibition nan % 10.1016/j.bmc.2014.06.006
Pasteurella multocida Pasteurella multocida MIC 2.5 ug.mL-1 10.1128/aac.00245-08
Pasteurella multocida Pasteurella multocida MIC 20.0 ug.mL-1 10.1128/aac.00245-08
Pasteurella multocida Pasteurella multocida MIC 40.0 ug.mL-1 10.1128/aac.00245-08
Pasteurella multocida Pasteurella multocida Ratio 2.0 None 10.1128/aac.00245-08
Pasteurella multocida Pasteurella multocida Ratio 16.0 None 10.1128/aac.00245-08
Proteus sp. Proteus sp. IZ 20.0 mm 10.1016/j.bmc.2016.01.041
Pseudomonas aeruginosa DNA gyrase Inhibition nan % 10.1016/j.ejmech.2013.09.025
Pseudomonas aeruginosa Pseudomonas aeruginosa Activity nan None 10.1021/acs.jmedchem.9b00876
Pseudomonas aeruginosa Pseudomonas aeruginosa FC 16.0 None 10.1128/aac.01024-08
Pseudomonas aeruginosa Pseudomonas aeruginosa FC 100000000.0 None 10.1128/aac.01071-07
Pseudomonas aeruginosa Pseudomonas aeruginosa FICI 0.35 None 10.1128/aac.01071-07
Pseudomonas aeruginosa Pseudomonas aeruginosa FICI 70.1 None 10.1128/aac.01071-07
Pseudomonas aeruginosa Pseudomonas aeruginosa IZ 14.0 mm 10.1016/j.bmc.2016.01.041
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 1.0 ug.mL-1 10.1128/aac.01235-07
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 1.562 ug.mL-1 10.1016/j.bmc.2008.12.034
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 1.75 ug.mL-1 10.1016/j.bmc.2018.05.016
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 4.0 ug.mL-1 10.1128/aac.01024-08
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 8.0 ug.mL-1 10.1021/jm200010x
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 8.0 ug.mL-1 10.1128/aac.01024-08
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 12.5 ug.mL-1 10.1128/aac.00511-08
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 16.0 ug.mL-1 10.1016/j.bmcl.2010.02.060
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 16.0 ug.mL-1 10.1128/aac.01024-08
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 32.0 ug.mL-1 10.1128/aac.01024-08
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 32.0 ug.mL-1 10.1128/aac.01235-07
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 64.0 ug.mL-1 10.1016/j.bmcl.2018.05.049
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 64.0 ug.mL-1 10.1128/aac.01024-08
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 100.0 ug.mL-1 10.1016/j.bmc.2016.04.043
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 140.0 ug.mL-1 10.1128/aac.01071-07
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 200.0 ug.mL-1 10.1128/aac.00511-08
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 256.0 ug.mL-1 10.1039/d2md00041e
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 512.0 ug.mL-1 10.1128/aac.01024-08
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 800.0 ug.mL-1 10.1128/aac.00511-08
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 1024.0 ug.mL-1 10.1021/acs.jmedchem.6b01742
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 1200.0 ug.mL-1 10.1128/aac.00511-08
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 1600.0 ug.mL-1 10.1128/aac.01071-07
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 4000.0 nM 10.1016/j.bmcl.2023.129301
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 256000.0 nM 10.1016/j.bmcl.2023.129301
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 512000.0 nM 10.1016/j.bmcl.2023.129301
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC nan None 10.1128/aac.01024-08
Pseudomonas fluorescens Pseudomonas fluorescens MIC 1.562 ug.mL-1 10.1016/j.bmc.2008.02.006
Pyricularia oryzae Pyricularia oryzae MIC 16.0 ug.mL-1 10.1021/jf400718w
Rattus norvegicus Androgen Receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Rattus norvegicus C6 Activity nan None 10.1021/np960144k
Rattus norvegicus Cyclooxygenase-1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Rattus norvegicus GABA receptor alpha-1 subunit AC50 30000.0 nM 10.1038/s41467-023-40064-9
Saccharomyces cerevisiae Saccharomyces cerevisiae IZ 0.0 mm 10.1016/j.ejmech.2010.07.050
Salmonella enterica Salmonella enterica MIC 0.5 ug.mL-1 10.1016/j.ejmech.2018.07.059
Salmonella enterica subsp. enterica serovar Typhimurium Salmonella typhimurium MIC 128.0 ug.mL-1 10.1128/aac.00079-09
Salmonella enterica subsp. enterica serovar Typhimurium Salmonella typhimurium MIC 256.0 ug.mL-1 10.1128/aac.00079-09
Salmonella enterica subsp. enterica serovar Typhimurium Salmonella typhimurium MIC 1024.0 ug.mL-1 10.1128/aac.01472-06
Severe acute respiratory syndrome coronavirus 2 Replicase polyprotein 1ab Inhibition 6.53 % 10.6019/CHEMBL4495564
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Hit score 0.09215 None 10.1101/2020.04.21.054387
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 IC50 19952.62 nM 10.6019/CHEMBL4651402
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 IC50 20000.0 nM 10.6019/CHEMBL4651402
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Inhibition -0.03 % 10.6019/CHEMBL4495565
Staphylococcus aureus DNA gyrase IC50 0.25 ug.mL-1 10.1016/j.bmc.2008.12.034
Staphylococcus aureus DNA gyrase IC50 0.28 ug.mL-1 10.1016/j.bmc.2008.02.006
Staphylococcus aureus DNA gyrase IC50 0.65 nM 10.1021/acs.jmedchem.2c01905
Staphylococcus aureus DNA gyrase IC50 4.0 nM 10.1016/j.bmc.2016.04.043
Staphylococcus aureus DNA gyrase IC50 4.0 nM 10.1016/j.bmcl.2012.09.071
Staphylococcus aureus DNA gyrase IC50 10.0 nM 10.1016/j.ejmech.2016.03.079
Staphylococcus aureus DNA gyrase IC50 10.0 nM 10.1021/acs.jmedchem.5b00489
Staphylococcus aureus DNA gyrase IC50 30.0 nM 10.1016/j.bmc.2014.09.008
Staphylococcus aureus DNA gyrase IC50 34.0 nM 10.1016/j.ejmech.2021.113200
Staphylococcus aureus DNA gyrase IC50 40.0 nM 10.1021/acs.jmedchem.5b00489
Staphylococcus aureus DNA gyrase IC50 40.0 nM 10.1021/acs.jmedchem.8b01750
Staphylococcus aureus DNA gyrase IC50 41.0 nM 10.1016/j.ejmech.2016.03.079
Staphylococcus aureus DNA gyrase IC50 41.0 nM 10.1016/j.ejmech.2017.02.046
Staphylococcus aureus DNA gyrase IC50 41.0 nM 10.1016/j.ejmech.2019.02.004
Staphylococcus aureus DNA gyrase IC50 41.0 nM 10.1021/acsmedchemlett.0c00416
Staphylococcus aureus DNA gyrase IC50 41.0 nM 10.1039/C9MD00224C
Staphylococcus aureus DNA gyrase IC50 125.0 nM 10.1021/acs.jmedchem.6b01834
Staphylococcus aureus DNA gyrase Inhibition nan % 10.1016/j.ejmech.2013.09.025
Staphylococcus aureus DNA gyrase Ki 10.0 nM 10.1021/jm800318d
Staphylococcus aureus DNA gyrase MIC 10.0 nM 10.1016/j.bmc.2015.08.004
Staphylococcus aureus DNA gyrase MNEC 0.25 ug ml-1 10.1021/jm000017s
Staphylococcus aureus DNA gyrase subunit B IC50 40.0 nM 10.1021/acs.jmedchem.6b00864
Staphylococcus aureus DNA gyrase subunit B IC50 41.0 nM 10.1016/j.ejmech.2016.09.040
Staphylococcus aureus DNA gyrase subunit B IC50 41.0 nM 10.1016/j.ejmech.2018.05.011
Staphylococcus aureus DNA gyrase subunit B IC50 125.0 nM 10.1016/j.bmc.2014.09.008
Staphylococcus aureus DNA gyrase subunit B Inhibition nan % 10.1016/j.bmc.2014.02.020
Staphylococcus aureus DNA topoisomerase 4 subunit B IC50 7900.0 nM 10.1016/j.ejmech.2019.112022
Staphylococcus aureus Staphylococcus aureus Activity nan None 10.1016/j.bmcl.2014.07.037
Staphylococcus aureus Staphylococcus aureus ED50 3.0 mg.kg-1 10.1021/jm0310232
Staphylococcus aureus Staphylococcus aureus ED50 3.0 mg.kg-1 10.1021/jm1014023
Staphylococcus aureus Staphylococcus aureus IC50 125.0 nM 10.1016/j.bmcl.2009.07.141
Staphylococcus aureus Staphylococcus aureus IC50 nan None 10.1016/j.bmc.2014.09.008
Staphylococcus aureus Staphylococcus aureus IZ 24.0 mm 10.1016/j.bmc.2016.01.041
Staphylococcus aureus Staphylococcus aureus IZ 25.0 mm 10.1016/j.ejmech.2021.113921
Staphylococcus aureus Staphylococcus aureus MIC 0.00125 ug.mL-1 10.1128/aac.00247-08
Staphylococcus aureus Staphylococcus aureus MIC 0.04 ug.mL-1 10.1016/s0960-894x(00)00304-8
Staphylococcus aureus Staphylococcus aureus MIC 0.04 ug.mL-1 10.1016/s0960-894x(01)00257-8
Staphylococcus aureus Staphylococcus aureus MIC 0.04 ug.mL-1 10.1016/s0960-894x(99)00329-7
Staphylococcus aureus Staphylococcus aureus MIC 0.04 ug.mL-1 10.1016/s0960-894x(99)00492-8
Staphylococcus aureus Staphylococcus aureus MIC 0.04 ug.mL-1 10.1016/s0960-894x(99)00493-x
Staphylococcus aureus Staphylococcus aureus MIC 0.04 ug.mL-1 10.1016/s0960-894x(99)00654-x
Staphylococcus aureus Staphylococcus aureus MIC 0.049 ug.mL-1 10.1128/aac.00971-08
Staphylococcus aureus Staphylococcus aureus MIC 0.06 ug.mL-1 10.1016/j.bmc.2016.04.043
Staphylococcus aureus Staphylococcus aureus MIC 0.06 ug.mL-1 10.1016/j.bmcl.2012.09.071
Staphylococcus aureus Staphylococcus aureus MIC 0.06 ug.mL-1 10.1016/j.bmcl.2018.05.049
Staphylococcus aureus Staphylococcus aureus MIC 0.12 ug.mL-1 10.1016/j.bmcl.2006.12.065
Staphylococcus aureus Staphylococcus aureus MIC 0.12 ug.mL-1 10.1021/jm0310232
Staphylococcus aureus Staphylococcus aureus MIC 0.12 ug.mL-1 10.1021/jm1014023
Staphylococcus aureus Staphylococcus aureus MIC 0.125 ug.mL-1 10.1016/j.bmc.2010.02.005
Staphylococcus aureus Staphylococcus aureus MIC 0.125 ug.mL-1 10.1016/j.bmcl.2007.04.074
Staphylococcus aureus Staphylococcus aureus MIC 0.125 ug.mL-1 10.1016/j.bmcl.2008.11.102
Staphylococcus aureus Staphylococcus aureus MIC 0.125 ug.mL-1 10.1016/j.bmcl.2009.07.141
Staphylococcus aureus Staphylococcus aureus MIC 0.125 ug.mL-1 10.1016/j.bmcl.2010.02.060
Staphylococcus aureus Staphylococcus aureus MIC 0.125 ug.mL-1 10.1016/j.bmcl.2011.08.035
Staphylococcus aureus Staphylococcus aureus MIC 0.125 ug.mL-1 10.1021/acs.jmedchem.6b01834
Staphylococcus aureus Staphylococcus aureus MIC 0.125 ug.mL-1 10.1021/acs.jmedchem.9b00876
Staphylococcus aureus Staphylococcus aureus MIC 0.125 ug.mL-1 10.1021/acsmedchemlett.5b00266
Staphylococcus aureus Staphylococcus aureus MIC 0.125 ug.mL-1 10.1021/jm030394f
Staphylococcus aureus Staphylococcus aureus MIC 0.125 ug.mL-1 10.1021/jm800318d
Staphylococcus aureus Staphylococcus aureus MIC 0.125 ug.mL-1 10.1128/aac.00209-07
Staphylococcus aureus Staphylococcus aureus MIC 0.125 ug.mL-1 10.1128/aac.00247-08
Staphylococcus aureus Staphylococcus aureus MIC 0.125 ug.mL-1 10.1128/aac.00708-07
Staphylococcus aureus Staphylococcus aureus MIC 0.13 ug.mL-1 10.1016/j.bmc.2020.115776
Staphylococcus aureus Staphylococcus aureus MIC 0.13 ug.mL-1 10.1021/jm200010x
Staphylococcus aureus Staphylococcus aureus MIC 0.13 ug.mL-1 10.1021/jm501174m
Staphylococcus aureus Staphylococcus aureus MIC 0.13 ug.mL-1 10.1128/aac.00596-06
Staphylococcus aureus Staphylococcus aureus MIC 0.15 ug.mL-1 10.1016/s0960-894x(99)00492-8
Staphylococcus aureus Staphylococcus aureus MIC 0.15 ug.mL-1 10.1016/s0960-894x(99)00493-x
Staphylococcus aureus Staphylococcus aureus MIC 0.19 ug.mL-1 10.1021/acs.jnatprod.1c01101
Staphylococcus aureus Staphylococcus aureus MIC 0.25 ug.mL-1 10.1016/j.bmc.2016.04.043
Staphylococcus aureus Staphylococcus aureus MIC 0.25 ug.mL-1 10.1016/j.bmcl.2004.03.044
Staphylococcus aureus Staphylococcus aureus MIC 0.25 ug.mL-1 10.1016/j.bmcl.2006.12.065
Staphylococcus aureus Staphylococcus aureus MIC 0.25 ug.mL-1 10.1016/j.bmcl.2010.02.060
Staphylococcus aureus Staphylococcus aureus MIC 0.25 ug.mL-1 10.1016/j.bmcl.2012.09.071
Staphylococcus aureus Staphylococcus aureus MIC 0.25 ug.mL-1 10.1016/s0960-894x(00)00109-8
Staphylococcus aureus Staphylococcus aureus MIC 0.25 ug.mL-1 10.1021/acs.jmedchem.6b01834
Staphylococcus aureus Staphylococcus aureus MIC 0.25 ug.mL-1 10.1021/acs.jnatprod.6b00235
Staphylococcus aureus Staphylococcus aureus MIC 0.25 ug.mL-1 10.1021/jm030394f
Staphylococcus aureus Staphylococcus aureus MIC 0.25 ug.mL-1 10.1021/jm0310232
Staphylococcus aureus Staphylococcus aureus MIC 0.25 ug.mL-1 10.1021/jm1014023
Staphylococcus aureus Staphylococcus aureus MIC 0.25 ug.mL-1 10.1021/jm200010x
Staphylococcus aureus Staphylococcus aureus MIC 0.25 ug.mL-1 10.1128/aac.00209-07
Staphylococcus aureus Staphylococcus aureus MIC 0.25 ug.mL-1 10.1128/aac.00596-06
Staphylococcus aureus Staphylococcus aureus MIC 0.25 ug.mL-1 10.1128/aac.01235-07
Staphylococcus aureus Staphylococcus aureus MIC 0.5 ug.mL-1 10.1016/j.bmcl.2007.04.074
Staphylococcus aureus Staphylococcus aureus MIC 0.5 ug.mL-1 10.1016/j.bmcl.2012.09.071
Staphylococcus aureus Staphylococcus aureus MIC 0.5 ug.mL-1 10.1128/aac.00596-06
Staphylococcus aureus Staphylococcus aureus MIC 0.625 ug.mL-1 10.1128/aac.00247-08
Staphylococcus aureus Staphylococcus aureus MIC 0.78 ug.mL-1 10.1016/j.bmc.2018.05.016
Staphylococcus aureus Staphylococcus aureus MIC 1.0 ug.mL-1 10.1016/j.bmcl.2007.04.074
Staphylococcus aureus Staphylococcus aureus MIC 1.0 ug.mL-1 10.1021/jm0310232
Staphylococcus aureus Staphylococcus aureus MIC 1.0 ug.mL-1 10.1128/aac.00596-06
Staphylococcus aureus Staphylococcus aureus MIC 1.0 ug.mL-1 10.1128/aac.00708-07
Staphylococcus aureus Staphylococcus aureus MIC 1.95 ug.mL-1 10.1016/j.bmc.2014.02.020
Staphylococcus aureus Staphylococcus aureus MIC 2.0 ug.mL-1 10.1016/j.ejmech.2018.07.059
Staphylococcus aureus Staphylococcus aureus MIC 2.0 ug.mL-1 10.1128/aac.00596-06
Staphylococcus aureus Staphylococcus aureus MIC 2.0 ug.mL-1 10.1128/aac.00708-07
Staphylococcus aureus Staphylococcus aureus MIC 2.0 ug.mL-1 10.1128/aac.00971-08
Staphylococcus aureus Staphylococcus aureus MIC 2.5 ug.mL-1 10.1016/s0960-894x(01)00257-8
Staphylococcus aureus Staphylococcus aureus MIC 3.125 ug.mL-1 10.1016/j.bmc.2008.02.006
Staphylococcus aureus Staphylococcus aureus MIC 3.125 ug.mL-1 10.1016/j.bmc.2008.12.034
Staphylococcus aureus Staphylococcus aureus MIC 4.0 ug.mL-1 10.1016/j.bmcl.2012.09.071
Staphylococcus aureus Staphylococcus aureus MIC 4.0 ug.mL-1 10.1021/jm030394f
Staphylococcus aureus Staphylococcus aureus MIC 4.3 ug.mL-1 10.1021/jm501174m
Staphylococcus aureus Staphylococcus aureus MIC 8.0 ug.mL-1 10.1016/j.bmcl.2006.12.065
Staphylococcus aureus Staphylococcus aureus MIC 8.0 ug.mL-1 10.1016/s0960-894x(00)00109-8
Staphylococcus aureus Staphylococcus aureus MIC 8.0 ug.mL-1 10.1021/jm200010x
Staphylococcus aureus Staphylococcus aureus MIC 8.0 ug.mL-1 10.1128/aac.00596-06
Staphylococcus aureus Staphylococcus aureus MIC 8.0 ug.mL-1 10.1128/aac.00708-07
Staphylococcus aureus Staphylococcus aureus MIC 10.0 ug.mL-1 10.1016/s0960-894x(00)00304-8
Staphylococcus aureus Staphylococcus aureus MIC 10.0 ug.mL-1 10.1016/s0960-894x(99)00654-x
Staphylococcus aureus Staphylococcus aureus MIC 16.0 ug.mL-1 10.1016/j.bmc.2016.04.043
Staphylococcus aureus Staphylococcus aureus MIC 16.0 ug.mL-1 10.1016/j.bmcl.2012.09.071
Staphylococcus aureus Staphylococcus aureus MIC 16.0 ug.mL-1 10.1016/s0960-894x(00)00109-8
Staphylococcus aureus Staphylococcus aureus MIC 16.0 ug.mL-1 10.1021/jm800318d
Staphylococcus aureus Staphylococcus aureus MIC 20.0 ug.mL-1 10.1016/s0960-894x(99)00329-7
Staphylococcus aureus Staphylococcus aureus MIC 20.0 ug.mL-1 10.1016/s0960-894x(99)00492-8
Staphylococcus aureus Staphylococcus aureus MIC 20.0 ug.mL-1 10.1016/s0960-894x(99)00493-x
Staphylococcus aureus Staphylococcus aureus MIC 32.0 ug.mL-1 10.1021/jm501174m
Staphylococcus aureus Staphylococcus aureus MIC 32.0 ug.mL-1 10.1128/aac.01235-07
Staphylococcus aureus Staphylococcus aureus MIC 64.0 ug.mL-1 10.1021/jf400718w
Staphylococcus aureus Staphylococcus aureus MIC 250.0 nM 10.1016/j.bmc.2014.09.008
Staphylococcus aureus Staphylococcus aureus MIC 256.0 ug.mL-1 10.1128/aac.00971-08
Staphylococcus aureus Staphylococcus aureus MIC 390.0 nM 10.1016/j.bmcl.2012.05.128
Staphylococcus aureus Staphylococcus aureus MIC 1024.0 ug.mL-1 10.1128/aac.00971-08
Staphylococcus aureus Staphylococcus aureus MIC 1270.0 nM 10.1016/j.bmc.2014.02.020
Staphylococcus aureus Staphylococcus aureus MIC nan None 10.1016/j.bmc.2014.02.020
Staphylococcus aureus Staphylococcus aureus MIC nan None 10.1016/j.bmc.2014.09.008
Staphylococcus aureus Staphylococcus aureus MIC nan None 10.1128/aac.01472-06
Staphylococcus aureus Staphylococcus aureus PD50 10.0 mg kg-1 10.1021/acsmedchemlett.5b00266
Staphylococcus aureus Staphylococcus aureus TIME 336.0 hr 10.1128/aac.01302-07
Staphylococcus aureus Topoisomerase IV IC50 13265.0 nM 10.1021/acs.jmedchem.2c01905
Staphylococcus aureus Topoisomerase IV IC50 20000.0 nM 10.1021/acs.jmedchem.5b00489
Staphylococcus aureus Topoisomerase IV IC50 27000.0 nM 10.1016/j.ejmech.2019.02.004
Staphylococcus aureus Topoisomerase IV IC50 27000.0 nM 10.1021/acs.jmedchem.5b00489
Staphylococcus aureus Topoisomerase IV IC50 27000.0 nM 10.1021/acsmedchemlett.0c00416
Staphylococcus aureus Topoisomerase IV IC50 27000.0 nM 10.1039/C9MD00224C
Staphylococcus aureus Topoisomerase IV IC50 35000.0 nM 10.1016/j.bmc.2016.04.043
Staphylococcus epidermidis Staphylococcus epidermidis MIC 0.04 ug.mL-1 10.1016/s0960-894x(00)00304-8
Staphylococcus epidermidis Staphylococcus epidermidis MIC 0.04 ug.mL-1 10.1016/s0960-894x(99)00654-x
Staphylococcus epidermidis Staphylococcus epidermidis MIC 0.06 ug.mL-1 10.1016/j.bmcl.2018.05.049
Staphylococcus epidermidis Staphylococcus epidermidis MIC 0.0625 ug.mL-1 10.1021/acs.jmedchem.9b00876
Staphylococcus epidermidis Staphylococcus epidermidis MIC 0.08 ug.mL-1 10.1016/s0960-894x(99)00329-7
Staphylococcus epidermidis Staphylococcus epidermidis MIC 0.08 ug.mL-1 10.1016/s0960-894x(99)00492-8
Staphylococcus epidermidis Staphylococcus epidermidis MIC 0.08 ug.mL-1 10.1016/s0960-894x(99)00493-x
Staphylococcus epidermidis Staphylococcus epidermidis MIC 0.12 ug.mL-1 10.1016/j.bmcl.2006.12.065
Staphylococcus epidermidis Staphylococcus epidermidis MIC 0.12 ug.mL-1 10.1016/s0960-894x(00)00109-8
Staphylococcus epidermidis Staphylococcus epidermidis MIC 0.25 ug.mL-1 10.1021/jm0310232
Staphylococcus epidermidis Staphylococcus epidermidis MIC 0.25 ug.mL-1 10.1021/jm1014023
Staphylococcus saprophyticus Staphylococcus saprophyticus MIC 16.0 ug.mL-1 10.1128/aac.00708-07
Stenotrophomonas maltophilia Stenotrophomonas maltophilia MIC 64.0 ug.mL-1 10.1021/jm0310232
Stenotrophomonas maltophilia Stenotrophomonas maltophilia MIC 64.0 ug.mL-1 10.1021/jm1014023
Streptococcus pneumoniae ParE IC50 2030.0 nM 10.1016/j.bmcl.2009.07.141
Streptococcus pneumoniae Streptococcus pneumoniae ED 100.0 mg kg-1 10.1021/acsmedchemlett.5b00266
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.13 ug.mL-1 10.1021/jm501174m
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.25 ug.mL-1 10.1021/jm200010x
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.5 ug.mL-1 10.1016/j.bmcl.2018.05.049
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.5 ug.mL-1 10.1021/jm401208b
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.5 ug.mL-1 10.1128/aac.00596-06
Streptococcus pneumoniae Streptococcus pneumoniae MIC 1.0 ug.mL-1 10.1016/j.bmc.2016.04.043
Streptococcus pneumoniae Streptococcus pneumoniae MIC 1.0 ug.mL-1 10.1016/j.bmcl.2012.09.071
Streptococcus pneumoniae Streptococcus pneumoniae MIC 1.0 ug.mL-1 10.1021/acs.jmedchem.6b01834
Streptococcus pneumoniae Streptococcus pneumoniae MIC 1.0 ug.mL-1 10.1021/jm501174m
Streptococcus pneumoniae Streptococcus pneumoniae MIC 1.0 ug.mL-1 10.1128/aac.01235-07
Streptococcus pneumoniae Streptococcus pneumoniae MIC 2.0 ug.mL-1 10.1021/acsmedchemlett.5b00266
Streptococcus pneumoniae Streptococcus pneumoniae MIC 2.0 ug.mL-1 10.1021/jm800318d
Streptococcus pneumoniae Streptococcus pneumoniae MIC 2.0 ug.mL-1 10.1128/aac.01235-07
Streptococcus pneumoniae Streptococcus pneumoniae MIC 4.0 ug.mL-1 10.1016/j.bmcl.2009.07.141
Streptococcus pneumoniae Streptococcus pneumoniae MIC 4.0 ug.mL-1 10.1128/aac.00596-06
Streptococcus pneumoniae Streptococcus pneumoniae MIC 8.0 ug.mL-1 10.1128/aac.00596-06
Streptococcus pneumoniae Streptococcus pneumoniae MIC 16.0 ug.mL-1 10.1021/jm501174m
Streptococcus pneumoniae Streptococcus pneumoniae MIC 780.0 nM 10.1016/j.bmcl.2012.05.128
Streptococcus pneumoniae Streptococcus pneumoniae MIC 4000.0 ug.mL-1 10.1016/j.bmcl.2009.07.141
Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4) DNA gyrase subunit B IC50 37.0 nM 10.1016/j.bmcl.2009.07.141
Streptococcus pyogenes Streptococcus pyogenes MIC 0.15 ug.mL-1 10.1016/s0960-894x(99)00329-7
Streptococcus pyogenes Streptococcus pyogenes MIC 0.3 ug.mL-1 10.1016/s0960-894x(00)00304-8
Streptococcus pyogenes Streptococcus pyogenes MIC 0.3 ug.mL-1 10.1016/s0960-894x(99)00654-x
Streptococcus pyogenes Streptococcus pyogenes MIC 1.0 ug.mL-1 10.1021/acs.jmedchem.6b01834
Streptococcus pyogenes Streptococcus pyogenes MIC 1.0 ug.mL-1 10.1021/jm1014023
Streptococcus pyogenes Streptococcus pyogenes MIC 2.0 ug.mL-1 10.1016/j.bmcl.2006.12.065
Streptococcus pyogenes Streptococcus pyogenes MIC 2.0 ug.mL-1 10.1016/s0960-894x(00)00109-8
Streptococcus pyogenes Streptococcus pyogenes MIC 3.24 ug.mL-1 10.1016/j.bmc.2018.05.016
Streptococcus pyogenes Streptococcus pyogenes MIC 8.0 ug.mL-1 10.1016/j.bmcl.2009.07.141
Streptomyces Streptomyces IZ 15.0 mm 10.1021/np900843b
Streptomyces Streptomyces IZ 18.0 mm 10.1021/np900843b
Streptomyces Streptomyces IZ 20.0 mm 10.1021/np900843b
Streptomyces acidiscabies Streptomyces acidiscabies DIZ nan None 10.1584/jpestics.28.183
Streptomyces acidiscabies Streptomyces acidiscabies IZ 14.0 mm 10.1584/jpestics.28.183
Streptomyces acidiscabies Streptomyces acidiscabies IZ 18.0 mm 10.1584/jpestics.28.183
Streptomyces acidiscabies Streptomyces acidiscabies IZ 39.0 mm 10.1584/jpestics.28.183
Streptomyces alboniger Streptomyces alboniger DIZ nan None 10.1584/jpestics.28.183
Streptomyces alboniger Streptomyces alboniger IZ 11.0 mm 10.1584/jpestics.28.183
Streptomyces alboniger Streptomyces alboniger IZ 21.0 mm 10.1584/jpestics.28.183
Streptomyces scabiei Streptomyces scabiei DIZ nan None 10.1584/jpestics.28.183
Streptomyces scabiei Streptomyces scabiei IZ 17.0 mm 10.1584/jpestics.28.183
Streptomyces scabiei Streptomyces scabiei IZ 26.0 mm 10.1584/jpestics.28.183
Streptomyces scabiei Streptomyces scabiei IZ 28.0 mm 10.1584/jpestics.28.183
Streptomyces scabiei Streptomyces scabiei IZ 44.0 mm 10.1584/jpestics.28.183
Zika virus Genome polyprotein EC50 15.21 ug.mL-1 10.1021/acs.jmedchem.9b00775
Zika virus Genome polyprotein EC50 24800.0 nM 10.1016/j.bmcl.2020.126965
Zika virus Genome polyprotein IC50 14200.0 nM 10.1016/j.bmcl.2020.126965
Zika virus Zika virus EC50 62200.0 nM 10.1016/j.ejmech.2019.07.007
None ADMET Activity 100.0 % 10.1021/acs.jmedchem.9b00876
None ADMET Ratio 1.0 None 10.1128/aac.00971-08
None Hepatotoxicity DILI positive/negative 1.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity Hepatotoxicity nan None 10.1021/tx1000865
None Hepatotoxicity Hepatotoxicity nan None 10.1021/tx900326k
None Hepatotoxicity Hepatotoxicity nan None 10.1124/dmd.110.035113
None NON-PROTEIN TARGET Activity 77.9 % 10.1021/jf400718w
None NON-PROTEIN TARGET Activity 78.2 % 10.1021/jf400718w
None NON-PROTEIN TARGET GI nan None 10.1016/j.ejmech.2016.06.042
None NON-PROTEIN TARGET Hepatotoxicity (acute) 0.0 % 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (animal toxicity known) nan None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (benign tumour) 0.0 None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (granulomatous hepatitis) 0.0 None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (mechanism) nan None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (moderate) 2.0 None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (moderate) 40.0 % 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (time to onset) nan None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET IC50 1050.0 nM 10.1016/j.bmc.2010.10.029
None NON-PROTEIN TARGET IC50 700000.0 nM 10.1016/j.ejmech.2014.10.034
None NON-PROTEIN TARGET IC50 700000.0 nM 10.1021/acs.jmedchem.5b01354
None NON-PROTEIN TARGET IC50 700000.0 nM 10.1021/ml400404s
None NON-PROTEIN TARGET IC50 700000.0 nM 10.1021/ml5004475
None NON-PROTEIN TARGET IC50 700000.0 nM 10.1039/C0MD00063A
None NON-PROTEIN TARGET IC50 700000000.0 nM 10.1016/j.bmcl.2014.05.020
None NON-PROTEIN TARGET LC50 690000.0 nM 10.1016/j.bmc.2014.06.006
None NON-PROTEIN TARGET MIC 0.25 ug.mL-1 10.1021/jm401208b
None NON-PROTEIN TARGET MIC 0.5 ug.mL-1 10.1021/jm030394f
None NON-PROTEIN TARGET MIC 1.0 ug.mL-1 10.1021/jm401208b
None NON-PROTEIN TARGET MIC 2.0 ug.mL-1 10.1016/j.bmcl.2011.08.035
None NON-PROTEIN TARGET MIC 2.0 ug.mL-1 10.1021/jm401208b
None NON-PROTEIN TARGET MIC 4.0 ug.mL-1 10.1021/jm401208b
None NON-PROTEIN TARGET MIC 64.0 ug.mL-1 10.1128/aac.00661-08
None NON-PROTEIN TARGET MIC 256.0 ug.mL-1 10.1128/aac.00661-08
None NON-PROTEIN TARGET MIC 512.0 ug.mL-1 10.1128/aac.00661-08
None NON-PROTEIN TARGET MIC 1024.0 ug.mL-1 10.1128/aac.00661-08
None NON-PROTEIN TARGET MIC nan None 10.1128/aac.00661-08
None NON-PROTEIN TARGET Potency 5951.8 nM None
None NON-PROTEIN TARGET Potency 11875.4 nM None
None NON-PROTEIN TARGET Potency 14950.2 nM None
None NON-PROTEIN TARGET Potency 18821.2 nM None
None NON-PROTEIN TARGET Range 8.0 ug ml-1 10.1021/jm0310232
None NON-PROTEIN TARGET Ratio 1.0 None 10.1021/jm401208b
None NON-PROTEIN TARGET Ratio 4.0 None 10.1021/jm401208b
None NON-PROTEIN TARGET Ratio 8.0 None 10.1021/jm401208b
None NON-PROTEIN TARGET Ratio 16.0 None 10.1021/jm401208b
None No relevant target LogD 1.58 None 10.1021/jm00169a014
None No relevant target pKa 3.6 None 10.1016/s0960-894x(01)00257-8
None Nucleic Acid IC50 0.25 ug.mL-1 10.1021/jm030394f
None Nucleic Acid IC50 3.5 ug.mL-1 10.1021/jm030394f
None Nucleic Acid IC50 25.0 ug.mL-1 10.1016/j.bmcl.2004.03.044
None Nucleic Acid IC50 28.0 ug.mL-1 10.1021/jm030394f
None Nucleic Acid IC50 400.0 ug.mL-1 10.1021/jm030394f
None Phospholipidosis Phospholipidosis nan None 10.1080/15376510701857262
None Radical scavenging activity Activity 47.7 % 10.1021/jf400718w
None Unchecked Activity 0.25 ug ml-1 10.1016/j.bmcl.2006.12.065
None Unchecked Activity 90.0 % 10.1021/np200029q
None Unchecked Activity nan None 10.1016/j.bmc.2008.11.058
None Unchecked Activity nan None 10.1016/j.ejmech.2010.07.050
None Unchecked Activity nan None 10.1021/jm0707774
None Unchecked Activity nan None 10.1021/np200029q
None Unchecked Activity nan None 10.1021/np960144k
None Unchecked EC50 100000.0 nM 10.1021/jm901566c
None Unchecked EC50 700000.0 nM 10.1039/C6MD00377J
None Unchecked FC 1.5 None 10.1016/j.bmc.2013.06.042
None Unchecked Hepatotoxicity (acute) 5.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (association with vascular disease) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (choleostasis) 3.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (chronic liver disease) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (cirrhosis) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (comment) nan None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (cytolytic) 2.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (malignant tumour) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (severe hepatitis) 2.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (steatosis) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (successful reintroduction) nan None 10.1016/s0399-8320(04)95062-2
None Unchecked IC50 0.31 ug.mL-1 10.1016/j.bmc.2008.02.006
None Unchecked IC50 0.5 ug.mL-1 10.1016/j.bmc.2008.12.034
None Unchecked IC50 0.5 ug.mL-1 10.1016/j.ejmech.2018.07.059
None Unchecked IC50 2.17 nM 10.1021/acs.jmedchem.2c01905
None Unchecked IC50 3.0 nM 10.1016/j.bmc.2012.02.052
None Unchecked IC50 3.0 nM 10.1016/j.bmcl.2009.12.060
None Unchecked IC50 4.0 ug.mL-1 10.1016/j.ejmech.2018.07.059
None Unchecked IC50 8.0 nM 10.1016/j.bmcl.2011.08.035
None Unchecked IC50 10.0 nM 10.1016/j.ejmech.2016.09.040
None Unchecked IC50 10.0 nM 10.1016/j.ejmech.2017.02.046
None Unchecked IC50 15.0 nM 10.1016/j.bmc.2012.02.052
None Unchecked IC50 15.0 nM 10.1016/j.ejmech.2019.112022
None Unchecked IC50 23.0 nM 10.1016/j.bmcl.2012.09.071
None Unchecked IC50 30.0 nM 10.1016/j.bmcl.2008.11.102
None Unchecked IC50 30.0 nM 10.1021/acs.jmedchem.6b01834
None Unchecked IC50 50.0 nM 10.1016/j.bmcl.2010.02.060
None Unchecked IC50 50.0 nM 10.1021/jm200010x
None Unchecked IC50 80.0 nM 10.1016/j.ejmech.2016.03.079
None Unchecked IC50 80.0 nM 10.1016/j.ejmech.2016.09.040
None Unchecked IC50 80.0 nM 10.1016/j.ejmech.2017.02.046
None Unchecked IC50 80.0 nM 10.1021/acs.jmedchem.7b00315
None Unchecked IC50 100.0 nM 10.1128/aac.00247-08
None Unchecked IC50 100.0 nM 10.1128/aac.01551-07
None Unchecked IC50 110.0 nM 10.1021/jm200010x
None Unchecked IC50 130.0 nM 10.1021/acs.jmedchem.5b00489
None Unchecked IC50 168.0 nM 10.1016/j.ejmech.2016.03.079
None Unchecked IC50 170.0 nM 10.1016/j.bmc.2016.10.038
None Unchecked IC50 170.0 nM 10.1016/j.ejmech.2017.02.046
None Unchecked IC50 180.0 nM 10.1016/j.bmc.2015.02.032
None Unchecked IC50 180.0 nM 10.1016/j.ejmech.2016.06.042
None Unchecked IC50 210.0 nM 10.1021/jm101121s
None Unchecked IC50 450.0 nM 10.1016/j.bmc.2016.04.043
None Unchecked IC50 450.0 nM 10.1016/j.bmcl.2012.09.071
None Unchecked IC50 500.0 nM 10.1016/j.bmcl.2012.09.071
None Unchecked IC50 500.0 nM 10.1021/acs.jmedchem.6b01834
None Unchecked IC50 800.0 nM 10.1128/aac.01551-07
None Unchecked IC50 820.4 nM 10.1016/j.bmc.2020.115776
None Unchecked IC50 1000.0 nM 10.1016/j.bmc.2009.05.014
None Unchecked IC50 1000.0 nM 10.1128/aac.00247-08
None Unchecked IC50 1320.0 nM 10.1016/j.bmcl.2008.11.102
None Unchecked IC50 2000.0 nM 10.1021/acs.jmedchem.6b01834
None Unchecked IC50 8000.0 nM 10.1021/acs.jmedchem.6b01834
None Unchecked IC50 8365.0 nM 10.1021/acs.jmedchem.2c01905
None Unchecked IC50 9465.0 nM 10.1021/acs.jmedchem.2c01905
None Unchecked IC50 10000.0 nM 10.1016/j.bmc.2016.04.043
None Unchecked IC50 10000.0 nM 10.1016/j.bmcl.2012.09.071
None Unchecked IC50 10000.0 nM 10.1016/j.ejmech.2016.03.079
None Unchecked IC50 10000.0 nM 10.1021/acs.jmedchem.5b00489
None Unchecked IC50 11000.0 nM 10.1016/j.ejmech.2017.02.046
None Unchecked IC50 11000.0 nM 10.1016/j.ejmech.2019.02.004
None Unchecked IC50 11000.0 nM 10.1016/j.ejmech.2021.113200
None Unchecked IC50 11000.0 nM 10.1021/acs.jmedchem.5b00489
None Unchecked IC50 11000.0 nM 10.1021/acs.jmedchem.6b00864
None Unchecked IC50 11000.0 nM 10.1021/acsmedchemlett.0c00416
None Unchecked IC50 11000.0 nM 10.1039/C9MD00224C
None Unchecked IC50 11000.0 nM 10.1039/d2md00049k
None Unchecked IC50 11100.0 nM 10.1016/j.ejmech.2016.03.079
None Unchecked IC50 20000.0 nM 10.1016/j.ejmech.2016.03.079
None Unchecked IC50 26700.0 nM 10.1016/j.ejmech.2016.03.079
None Unchecked IC50 27000.0 nM 10.1016/j.ejmech.2017.02.046
None Unchecked IC50 27000.0 nM 10.1016/j.ejmech.2018.05.011
None Unchecked IC50 27000.0 nM 10.1016/j.ejmech.2021.113200
None Unchecked IC50 27000.0 nM 10.1021/acs.jmedchem.6b00864
None Unchecked IC50 32000.0 nM 10.1021/acs.jmedchem.6b01834
None Unchecked IC50 35000.0 nM 10.1016/j.bmcl.2012.09.071
None Unchecked IC50 42000.0 nM 10.1016/j.ejmech.2018.05.011
None Unchecked IC50 46000.0 nM 10.1016/j.ejmech.2014.08.018
None Unchecked IC50 63430.0 nM 10.1016/j.bmc.2017.03.019
None Unchecked IC50 63430.0 nM 10.1016/j.ejmech.2016.07.063
None Unchecked IC50 128000.0 nM 10.1021/acs.jmedchem.6b01834
None Unchecked IC50 468000.0 nM 10.1016/j.ejmech.2022.114844
None Unchecked IC50 500000.0 nM 10.1021/np070190s
None Unchecked IC50 nan None 10.1021/jm200010x
None Unchecked Inhibition 10.0 % 10.1016/j.bmcl.2004.10.046
None Unchecked Inhibition 20.0 % 10.1016/j.bmcl.2004.10.046
None Unchecked Inhibition 38.54 % 10.1016/j.bmc.2017.07.003
None Unchecked Inhibition 45.86 % 10.1016/j.bmc.2017.07.003
None Unchecked Inhibition 60.23 % 10.1016/j.bmc.2017.07.003
None Unchecked Inhibition 61.0 % 10.1016/j.ejmech.2014.08.018
None Unchecked Inhibition 78.9 % 10.1016/j.ejmech.2022.114844
None Unchecked Inhibition 80.0 % 10.1016/j.bmcl.2004.10.046
None Unchecked Inhibition nan % 10.1016/j.bmc.2013.06.042
None Unchecked Inhibition nan % 10.1016/j.bmc.2014.02.020
None Unchecked Inhibition nan % 10.1016/j.bmcl.2004.10.046
None Unchecked Inhibition nan % 10.1016/j.bmcl.2018.05.049
None Unchecked Inhibition nan % 10.1016/j.ejmech.2013.09.025
None Unchecked Inhibition nan % 10.1021/np200029q
None Unchecked Kd 19.0 nM 10.1016/j.ejmech.2016.03.079
None Unchecked Kd 28.0 nM 10.1016/j.ejmech.2016.03.079
None Unchecked Kd 28.0 nM 10.1021/jm300395d
None Unchecked Kd 120000.0 nM 10.1021/jm101121s
None Unchecked Ki 14.0 nM 10.1021/jm800318d
None Unchecked Ki 110.0 nM 10.1021/jm800318d
None Unchecked Ki 60000.0 nM 10.1021/jm201645r
None Unchecked Log CR 0.28 None 10.1021/jm00169a014
None Unchecked MIC 2500.0 nM 10.1016/j.bmc.2015.08.004
None Unchecked Ratio 1.0 None 10.1016/s0960-894x(00)00304-8
None Unchecked Ratio 1.0 None 10.1016/s0960-894x(99)00654-x
None Unchecked Ratio 64.0 None 10.1128/aac.00708-07
None Unchecked Ratio 128.0 None 10.1021/acs.jmedchem.2c01905
None Unchecked Ratio IC50 64.0 None 10.1021/acs.jmedchem.6b01834
None Unchecked Selectivity Index nan None 10.1016/j.ejmech.2014.08.018
None Unchecked Time nan None 10.1128/aac.00620-10
None Unchecked TIME 0.005556 hr 10.1128/aac.00620-10

Metabolism Information

AKRT ID Reaction Reaction Link ID
AKRT011267 CO[C@@H]1[C@@H](O)[C@@H](O)[C@H](Oc2ccc3c(O)c(NC(=O)c4ccc(O)c(CC=C(C)C)c4)c(=O)oc3c2C)OC1(C)C.NC(=O)OP(=O)(O)O>>CO[C@@H]1[C@@H](OC(N)=O)[C@@H](O)[C@H](Oc2ccc3c(O)c(NC(=O)c4ccc(O)c(CC=C(C)C)c4)c(=O)oc3c2C)OC1(C)C RXN-14546