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Cepharadione A

AlkaPlorer ID: AK016672

Synonym: 7-Methyl-5H-benzo[g]-1,3-benzodioxolo[6,5,4-de]quinoline-5,6(7H)-dione 

IUPAC Name: 11-methyl-3,5-dioxa-11-azapentacyclo[10.7.1.02,6.08,20.014,19]icosa-1(20),2(6),7,12,14,16,18-heptaene-9,10-dione

Structure

SMILES: CN1C(=O)C(=O)C2=CC3=C(OCO3)C3=C4C=CC=CC4=CC1=C23

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InChI: InChI=1S/C18H11NO4/c1-19-12-6-9-4-2-3-5-10(9)15-14(12)11(16(20)18(19)21)7-13-17(15)23-8-22-13/h2-7H,8H2,1H3

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InChIKey: RZIGKFTVXWUUCX-UHFFFAOYSA-N

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Source

Species Genus Family Order Class Phylum Kingdom Domain
Piper caninum Piper Piperaceae Piperales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Sargassum fulvellum Sargassum Sargassaceae Fucales Phaeophyceae None None Eukaryota
Aristolochia mollissima Aristolochia Aristolochiaceae Piperales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Piper auritum Piper Piperaceae Piperales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Doronicum grandiflorum Doronicum Asteraceae Asterales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Dictyodendrilla cavernosa Dictyodendrilla Dictyodendrillidae Dendroceratida Demospongiae Porifera Metazoa Eukaryota
Aristolochia indica Aristolochia Aristolochiaceae Piperales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Conus gladiator Conus Conidae Neogastropoda Gastropoda Mollusca Metazoa Eukaryota
Lithocarpus haipinii Lithocarpus Fagaceae Fagales Magnoliopsida Streptophyta Viridiplantae Eukaryota
None Stephania Menispermaceae Ranunculales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Piper sanctum Piper Piperaceae Piperales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Stolonica socialis Stolonica Styelidae Stolidobranchia Ascidiacea Chordata Metazoa Eukaryota
Sphaerophysa salsula Sphaerophysa Fabaceae Fabales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Oxytropis lanata Oxytropis Fabaceae Fabales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Populus balsamifera Populus Salicaceae Malpighiales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Tephrosia crassifolia Tephrosia Fabaceae Fabales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Euphorbia characias Euphorbia Euphorbiaceae Malpighiales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Leibnitzia anandria Leibnitzia Asteraceae Asterales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Moesziomyces antarcticus Moesziomyces Ustilaginaceae Ustilaginales Ustilaginomycetes Basidiomycota Fungi Eukaryota
None Stephania Menispermaceae Ranunculales Magnoliopsida Streptophyta Viridiplantae Eukaryota
None Stephania Menispermaceae Ranunculales Magnoliopsida Streptophyta Viridiplantae Eukaryota

Properties Information

Molecule Weight: 305.28900000000004

TPSA？: 55.84

MolLogP？: 2.8808000000000016

Number of H-Donors: 0

Number of H-Acceptors: 4

RingCount: 5

Activities Information

Organism Target Name Standard Type Standard Value Standard Units doi
Homo sapiens 786-0 GI50 7227.7 nM None
Homo sapiens A498 GI50 100000.0 nM None
Homo sapiens A549 GI50 33728.73 nM None
Homo sapiens ACHN GI50 18836.49 nM None
Homo sapiens BXPC-3 GI50 10.0 ug.mL-1 10.1016/j.bmc.2007.06.035
Homo sapiens CAKI-1 GI50 31260.79 nM None
Homo sapiens CCRF-CEM GI50 8953.65 nM None
Homo sapiens COLO 205 GI50 28707.81 nM None
Homo sapiens DLD-1 GI50 31188.9 nM None
Homo sapiens DMS-114 GI50 31550.05 nM None
Homo sapiens DMS-273 GI50 22908.68 nM None
Homo sapiens DU-145 GI50 4.3 ug.mL-1 10.1016/j.bmc.2007.06.035
Homo sapiens EKVX GI50 69662.65 nM None
Homo sapiens HCC 2998 GI50 49090.79 nM None
Homo sapiens HCT-116 GI50 15559.66 nM None
Homo sapiens HCT-15 GI50 36057.86 nM None
Homo sapiens HL-60 GI50 38459.18 nM None
Homo sapiens HOP-18 GI50 42854.85 nM None
Homo sapiens HOP-62 GI50 41209.75 nM None
Homo sapiens HOP-92 GI50 100000.0 nM None
Homo sapiens HT-29 GI50 34434.99 nM None
Homo sapiens IGROV-1 GI50 37583.74 nM None
Homo sapiens K562 GI50 27227.01 nM None
Homo sapiens KM12 GI50 18323.14 nM None
Homo sapiens KM-20L2 GI50 17.3 ug.mL-1 10.1016/j.bmc.2007.06.035
Homo sapiens KM-20L2 GI50 39355.01 nM None
Homo sapiens LOX IMVI GI50 23014.42 nM None
Homo sapiens LXFL 529 GI50 30831.88 nM None
Homo sapiens M14 GI50 26730.06 nM None
Homo sapiens M19-MEL GI50 28379.19 nM None
Homo sapiens Malme-3M GI50 38815.04 nM None
Homo sapiens MCF7 GI50 6.3 ug.mL-1 10.1016/j.bmc.2007.06.035
Homo sapiens MOLT-4 GI50 17864.88 nM None
Homo sapiens NCI-H226 GI50 25234.81 nM None
Homo sapiens NCI-H23 GI50 40738.03 nM None
Homo sapiens NCI-H322M GI50 20749.14 nM None
Homo sapiens NCI-H460 GI50 2.5 ug.mL-1 10.1016/j.bmc.2007.06.035
Homo sapiens NCI-H460 GI50 26730.06 nM None
Homo sapiens NCI-H522 GI50 22594.36 nM None
Homo sapiens OVCAR-3 GI50 62086.9 nM None
Homo sapiens OVCAR-4 GI50 58613.82 nM None
Homo sapiens OVCAR-5 GI50 48752.85 nM None
Homo sapiens OVCAR-8 GI50 24099.05 nM None
Homo sapiens RPMI-8226 GI50 25118.86 nM None
Homo sapiens RXF 393 GI50 25585.86 nM None
Homo sapiens SF-268 GI50 2.9 ug.mL-1 10.1016/j.bmc.2007.06.035
Homo sapiens SF-268 GI50 21877.62 nM None
Homo sapiens SF-295 GI50 38725.76 nM None
Homo sapiens SF-539 GI50 45603.69 nM None
Homo sapiens SK-MEL-2 GI50 46665.94 nM None
Homo sapiens SK-MEL-28 GI50 40457.59 nM None
Homo sapiens SK-MEL-5 GI50 28444.61 nM None
Homo sapiens SK-OV-3 GI50 50350.06 nM None
Homo sapiens SN12C GI50 37670.38 nM None
Homo sapiens SNB-19 GI50 47424.2 nM None
Homo sapiens SNB-75 GI50 39174.19 nM None
Homo sapiens SNB-78 GI50 7834.3 nM None
Homo sapiens SR GI50 7498.94 nM None
Homo sapiens SW-620 GI50 35399.73 nM None
Homo sapiens TK-10 GI50 52480.75 nM None
Homo sapiens U-251 GI50 43351.09 nM None
Homo sapiens UACC-257 GI50 51522.86 nM None
Homo sapiens UACC-62 GI50 16943.38 nM None
Homo sapiens UO-31 GI50 20230.19 nM None
Homo sapiens XF498 GI50 100000.0 nM None
Saccharomyces cerevisiae Saccharomyces cerevisiae IC50 0.05 ug.mL-1 10.1021/np040056x
Saccharomyces cerevisiae Saccharomyces cerevisiae IC50 0.2 ug.mL-1 10.1021/np040056x
Saccharomyces cerevisiae Saccharomyces cerevisiae IC50 115.0 ug.mL-1 10.1021/np040056x

Metabolism Information