Molecule

2-[(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)amino}phenyl)formamido]pentanedioic acid

AlkaPlorer ID: AK016767

Synonym: None

IUPAC Name: (2S)-2-[[4-[(2,4-diaminopteridin-6-yl)methyl-methylamino]benzoyl]amino]pentanedioic acid

Structure

SMILES: CN(CC1=NC2=C(N)N=C(N)N=C2N=C1)C1=CC=C(C(=O)N[C@@H](CCC(=O)O)C(=O)O)C=C1

InChI: InChI=1S/C20H22N8O5/c1-28(9-11-8-23-17-15(24-11)16(21)26-20(22)27-17)12-4-2-10(3-5-12)18(31)25-13(19(32)33)6-7-14(29)30/h2-5,8,13H,6-7,9H2,1H3,(H,25,31)(H,29,30)(H,32,33)(H4,21,22,23,26,27)/t13-/m0/s1

InChIKey: FBOZXECLQNJBKD-ZDUSSCGKSA-N

Reference

PubChem CID: 126941

CAS: 1082707-84-3

NPASS: NPC331654

Source

Species	Genus	Family	Order	Class	Phylum	Kingdom	Domain
Asimina triloba	Asimina	Annonaceae	Magnoliales	Magnoliopsida	Streptophyta	Viridiplantae	Eukaryota
Quambalaria cyanescens	Quambalaria	Quambalariaceae	Microstromatales	Exobasidiomycetes	Basidiomycota	Fungi	Eukaryota

Properties Information

Molecule Weight: 454.4470000000002

TPSA？: 210.54

MolLogP？: 0.2684000000000009

Number of H-Donors: 5

Number of H-Acceptors: 10

RingCount: 3

Activities Information

Organism	Target Name	Standard Type	Standard Value	Standard Units	doi
Babesia gibsoni	Babesia gibsoni	Inhibition	nan	%	10.1128/aac.00384-08
Bacillus anthracis	Dihydrofolate reductase	IC50	12.2	nM	10.1128/aac.01666-08
Bacillus anthracis	Dihydrofolate reductase	IC50	15.0	nM	10.1128/aac.01666-08
Bacillus subtilis	4'-phosphopantetheinyl transferase ffp	Potency	50118.7	nM	None
Bacillus subtilis	Bacillus subtilis	IZ	8.0	mm	10.1016/j.ejmech.2013.05.039
Bacillus subtilis (strain 168)	ATP-dependent Clp protease proteolytic subunit	Potency	15848.9	nM	None
Bacillus subtilis (strain 168)	ATP-dependent Clp protease proteolytic subunit	Potency	31622.8	nM	None
Bos taurus	Dihydrofolate reductase	IC50	1.7	nM	10.1021/jm00145a012
Bos taurus	Dihydrofolate reductase	IC50	3.3	nM	10.1021/jm00371a009
Bos taurus	Dihydrofolate reductase	IC50	3.4	nM	10.1016/j.bmc.2009.11.065
Bos taurus	Dihydrofolate reductase	IC50	8.0	nM	10.1016/j.bmcl.2014.07.070
Bos taurus	Dihydrofolate reductase	IC50	8.0	nM	10.1016/j.bmcl.2016.08.022
Bos taurus	Dihydrofolate reductase	IC50	9.9	ug.mL-1	10.1021/jm00131a003
Bos taurus	Dihydrofolate reductase	IC50	10.8	ug.mL-1	10.1021/jm00131a003
Bos taurus	Dihydrofolate reductase	IC50	12.1	ug.mL-1	10.1021/jm00131a003
Bos taurus	Dihydrofolate reductase	IC50	36.0	ug.mL-1	10.1021/jm00131a003
Bos taurus	Dihydrofolate reductase	IC50	40.0	ug.mL-1	10.1021/jm00131a003
Bos taurus	Dihydrofolate reductase	IC50	42.0	ug.mL-1	10.1021/jm00131a003
Bos taurus	Dihydrofolate reductase	IC50	43.0	ug.mL-1	10.1021/jm00131a003
Bos taurus	Dihydrofolate reductase	IC50	45.0	ug.mL-1	10.1021/jm00131a003
Bos taurus	Dihydrofolate reductase	IC50	46.0	ug.mL-1	10.1021/jm00131a003
Bos taurus	Dihydrofolate reductase	IC50	49.0	ug.mL-1	10.1021/jm00131a003
Bos taurus	Dihydrofolate reductase	IC50	50.0	ug.mL-1	10.1021/jm00131a003
Bos taurus	Dihydrofolate reductase	IC50	52.0	ug.mL-1	10.1021/jm00131a003
Bos taurus	Dihydrofolate reductase	IC50	53.0	ug.mL-1	10.1021/jm00131a003
Bos taurus	Dihydrofolate reductase	IC50	57.0	ug.mL-1	10.1021/jm00131a003
Bos taurus	Dihydrofolate reductase	IC50	58.0	ug.mL-1	10.1021/jm00131a003
Bos taurus	Dihydrofolate reductase	IC50	59.0	ug.mL-1	10.1021/jm00131a003
Bos taurus	Dihydrofolate reductase	IC50	60.0	ug.mL-1	10.1021/jm00131a003
Bos taurus	Dihydrofolate reductase	IC50	61.0	ug.mL-1	10.1021/jm00131a003
Bos taurus	Dihydrofolate reductase	IC50	62.0	ug.mL-1	10.1021/jm00131a003
Bos taurus	Dihydrofolate reductase	IC50	63.0	ug.mL-1	10.1021/jm00131a003
Bos taurus	Dihydrofolate reductase	IC50	66.0	ug.mL-1	10.1021/jm00131a003
Bos taurus	Dihydrofolate reductase	IC50	69.0	ug.mL-1	10.1021/jm00131a003
Bos taurus	Dihydrofolate reductase	IC50	72.0	ug.mL-1	10.1021/jm00131a003
Bos taurus	Dihydrofolate reductase	IC50	80.0	nM	10.1016/j.bmc.2010.03.019
Bos taurus	Dihydrofolate reductase	IC50	80.0	nM	10.1016/j.ejmech.2012.12.061
Bos taurus	Dihydrofolate reductase	IC50	80.0	nM	10.1016/j.ejmech.2013.05.039
Bos taurus	Dihydrofolate reductase	IC50	80.0	nM	10.1016/j.ejmech.2014.01.004
Bos taurus	Dihydrofolate reductase	IC50	7943282.35	nM	10.1021/jm00163a067
Bos taurus	Dihydrofolate reductase	ID50	4.8e-09	M	10.1021/jm00142a025
Bos taurus	Dihydrofolate reductase	Ratio	16.0	None	10.1021/jm00131a003
Bos taurus	Dihydrofolate reductase	Ratio	17.0	None	10.1021/jm00131a003
Bos taurus	Dihydrofolate reductase	Ratio	18.0	None	10.1021/jm00131a003
Bos taurus	Dihydrofolate reductase	Ratio	19.0	None	10.1021/jm00131a003
Bos taurus	Dihydrofolate reductase	Ratio	20.0	None	10.1021/jm00131a003
Bos taurus	Dihydrofolate reductase	Ratio	21.0	None	10.1021/jm00131a003
Bos taurus	Dihydrofolate reductase	Ratio	23.0	None	10.1021/jm00131a003
Bos taurus	Dihydrofolate reductase	Ratio	25.0	None	10.1021/jm00131a003
Bos taurus	Dihydrofolate reductase	Ratio	26.0	None	10.1021/jm00131a003
Bos taurus	Dihydrofolate reductase	Ratio	27.0	None	10.1021/jm00131a003
Bos taurus	Dihydrofolate reductase	Ratio	28.0	None	10.1021/jm00131a003
Bos taurus	Dihydrofolate reductase	Ratio	29.0	None	10.1021/jm00131a003
Bos taurus	Dihydrofolate reductase	Ratio	100.0	None	10.1021/jm00131a003
Bos taurus	Progesterone receptor	IC50	nan	None	None
Bos taurus	Progesterone receptor	Ki	nan	None	None
Candida albicans	Candida albicans	IZ	8.0	mm	10.1016/j.ejmech.2013.05.039
Canis lupus familiaris	Canis familiaris	CL	0.217	mL.min-1.kg-1	10.1124/dmd.112.049312
Canis lupus familiaris	Canis familiaris	CL	0.344	mL.min-1.kg-1	10.1124/dmd.112.049312
Cavia porcellus	Leukotriene C4 synthase	IC50	nan	None	None
Cavia porcellus	Leukotriene C4 synthase	Ki	nan	None	None
Cavia porcellus	Serotonin 4 (5-HT4) receptor	IC50	nan	None	None
Cavia porcellus	Serotonin 4 (5-HT4) receptor	Ki	nan	None	None
Chlorocebus sabaeus	Vero	IC50	9.2	nM	10.1021/jm9505122
Chlorocebus sabaeus	Vero	ID50	0.02	uM	10.1021/jm00083a017
Chlorocebus sabaeus	Vero C1008	CC50	50.0	nM	10.6019/CHEMBL4495565
Cricetulus griseus	CHO	Log CR	0.04	None	10.1021/jm00169a014
Cryptosporidium parvum	Bifunctional dihydrofolate reductase-thymidylate synthase	Activity	nan	None	10.1039/c3md00141e
Enterococcus faecalis	Enterococcus faecalis	Activity	nan	None	10.1021/jm00192a024
Enterococcus faecium	Dihydrofolate reductase	IC50	1.4	nM	10.1021/jm00214a030
Enterococcus faecium	Enterococcus faecium	Concentration	0.05	ng ml-1	10.1021/jm00352a026
Enterococcus faecium	Enterococcus faecium	Concentration	3500.0	ng ml-1	10.1021/jm00352a026
Enterococcus faecium	Enterococcus faecium	IC50	5e-05	ug.mL-1	10.1021/jm00175a011
Enterococcus faecium	Enterococcus faecium	IC50	0.00012	ug.mL-1	10.1021/jm00157a600
Enterococcus faecium	Enterococcus faecium	IC50	0.00012	ug.mL-1	10.1021/jm00358a030
Enterococcus faecium	Enterococcus faecium	IC50	0.00015	ug.mL-1	10.1021/jm00141a010
Enterococcus faecium	Enterococcus faecium	IC50	0.0002	ug.mL-1	10.1021/jm00159a039
Enterococcus faecium	Enterococcus faecium	IC50	0.00026	ug.mL-1	10.1021/jm00156a029
Enterococcus faecium	Enterococcus faecium	IC50	0.0004	ug.mL-1	10.1021/jm00156a026
Enterococcus faecium	Enterococcus faecium	IC50	0.3	nM	10.1021/jm00159a032
Enterococcus faecium	Enterococcus faecium	IC50	0.8	nM	10.1021/jm00396a022
Enterococcus faecium	Enterococcus faecium	IC50	0.9	nM	10.1021/jm00126a022
Enterococcus faecium	Enterococcus faecium	IC50	2.0	nM	10.1021/jm00212a010
Enterococcus faecium	Enterococcus faecium	IC50	2.9	ug.mL-1	10.1021/jm00157a600
Enterococcus faecium	Enterococcus faecium	IC50	2.9	ug.mL-1	10.1021/jm00358a030
Enterococcus faecium	Enterococcus faecium	IC50	3.0	ug.mL-1	10.1021/jm00156a029
Enterococcus faecium	Enterococcus faecium	IC50	3.3	ug.mL-1	10.1021/jm00159a039
Enterococcus faecium	Enterococcus faecium	IC50	3.5	ug.mL-1	10.1021/jm00175a011
Enterococcus faecium	Enterococcus faecium	IC50	10.0	nM	10.1021/jm00212a010
Enterococcus faecium	Enterococcus faecium	IC50	90.0	nM	10.1021/jm00349a024
Enterococcus faecium	Enterococcus faecium	IC50	3900.0	nM	10.1021/jm00159a032
Enterococcus faecium	Enterococcus faecium	IC50	8000.0	nM	10.1021/jm00396a022
Enterococcus faecium	Enterococcus faecium	IC50	7200000.0	nM	10.1021/jm00349a024
Enterococcus faecium	Enterococcus faecium	Inhibition	0.15	%	10.1021/jm00369a024
Enterococcus faecium	Enterococcus faecium	Inhibition	5000.0	%	10.1021/jm00369a024
Enterococcus faecium	Enterococcus faecium	Inhibition	nan	%	10.1021/jm00212a010
Enterococcus faecium	Enterococcus faecium	Ratio IC50	5.0	None	10.1021/jm00212a010
Equus caballus	Ferritin light chain	Potency	31622.8	nM	None
Equus caballus	Ferritin light chain	Potency	39810.7	nM	None
Escherichia coli	Dihydrofolate reductase	IC50	2.2	nM	10.1021/jm950786p
Escherichia coli	Dihydrofolate reductase	IC50	3.0	nM	10.1021/jm060570v
Escherichia coli	Dihydrofolate reductase	IC50	4.4	nM	10.1016/j.bmc.2011.03.067
Escherichia coli	Dihydrofolate reductase	IC50	6.0	nM	10.1021/jm000200l
Escherichia coli	Dihydrofolate reductase	IC50	6.0	nM	10.1021/jm0202369
Escherichia coli	Dihydrofolate reductase	IC50	6.6	nM	10.1016/j.bmc.2009.11.029
Escherichia coli	Dihydrofolate reductase	IC50	6.6	nM	10.1021/jm058234m
Escherichia coli	Dihydrofolate reductase	IC50	6.6	nM	10.1021/jm800244v
Escherichia coli	Dihydrofolate reductase	IC50	6.6	nM	10.1021/jm9011142
Escherichia coli	Dihydrofolate reductase	IC50	7.0	nM	10.1021/jm0203534
Escherichia coli	Dihydrofolate reductase	IC50	7.0	nM	10.1021/jm040123k
Escherichia coli	Dihydrofolate reductase	IC50	7.0	nM	10.1021/jm058213s
Escherichia coli	Dihydrofolate reductase	IC50	8.8	nM	10.1016/j.bmc.2012.05.068
Escherichia coli	Dihydrofolate reductase	IC50	8.8	nM	10.1021/jm8006933
Escherichia coli	Dihydrofolate reductase	IC50	8.8	nM	10.1021/jm900490a
Escherichia coli	Dihydrofolate reductase	IC50	9.0	nM	10.1021/jm000130i
Escherichia coli	Dihydrofolate reductase	IC50	9.0	nM	10.1021/jm010575m
Escherichia coli	Dihydrofolate reductase	IC50	32.0	nM	10.1021/jm040144e
Escherichia coli	Dihydrofolate reductase	IC50	4400.0	nM	10.1021/jm0100382
Escherichia coli	Dihydrofolate reductase	Kd	0.023	nM	10.1021/jm00396a019
Escherichia coli	Dihydrofolate reductase	Kd	0.096	nM	10.1021/jm00396a019
Escherichia coli	Dihydrofolate reductase	Kd	1.0	nM	10.1016/j.bmcl.2004.01.106
Escherichia coli	Dihydrofolate reductase	Kd	2.3	nM	10.1021/jm00396a019
Escherichia coli	Dihydrofolate reductase	Kd	3.2	nM	10.1021/jm00396a019
Escherichia coli	Dihydrofolate reductase	Kd	31.0	nM	10.1021/jm00396a019
Escherichia coli	Dihydrofolate reductase	Kd	84.0	nM	10.1021/jm00396a019
Escherichia coli	Dihydrofolate reductase	Kd	140.0	nM	10.1021/jm00396a019
Escherichia coli	Dihydrofolate reductase	Kd	1100.0	nM	10.1021/jm00396a019
Escherichia coli	Dihydrofolate reductase	Kd	1700.0	nM	10.1021/jm00396a019
Escherichia coli	Dihydrofolate reductase	keq	0.14	None	10.1021/jm00396a019
Escherichia coli	Dihydrofolate reductase	keq	0.24	None	10.1021/jm00396a019
Escherichia coli	Dihydrofolate reductase	Keq	0.72	None	10.1021/jm00396a019
Escherichia coli	Dihydrofolate reductase	Kf	170.0	s-1	10.1021/jm00396a019
Escherichia coli	Dihydrofolate reductase	Kf	1080.0	s-1	10.1021/jm00396a019
Escherichia coli	Dihydrofolate reductase	Kf	21000.0	s-1	10.1021/jm00396a019
Escherichia coli	Dihydrofolate reductase	Ki	0.001	nM	10.1021/acsmedchemlett.6b00120
Escherichia coli	Dihydrofolate reductase	Ki	0.021	nM	10.1021/jm00381a008
Escherichia coli	Dihydrofolate reductase	Ki	330.0	nM	10.1021/jm00396a019
Escherichia coli	Dihydrofolate reductase	Ki	2400.0	nM	10.1021/jm00396a019
Escherichia coli	Dihydrofolate reductase	Ki	170000.0	nM	10.1021/jm00396a019
Escherichia coli	Dihydrofolate reductase	Kiso	5400.0	None	10.1021/jm00396a019
Escherichia coli	Dihydrofolate reductase	Kiso	33000.0	None	10.1021/jm00396a019
Escherichia coli	Dihydrofolate reductase	Kiso	440000.0	None	10.1021/jm00396a019
Escherichia coli	Dihydrofolate reductase	k_off	12.0	s-1	10.1021/jm00396a019
Escherichia coli	Dihydrofolate reductase	k_off	26.0	s-1	10.1021/jm00396a019
Escherichia coli	Dihydrofolate reductase	k_on	150000.0	M-1.s-1	10.1021/jm00396a019
Escherichia coli	Dihydrofolate reductase	k_on	11000000.0	M-1.s-1	10.1021/jm00396a019
Escherichia coli	Dihydrofolate reductase	k_on	36000000.0	M-1.s-1	10.1021/jm00396a019
Escherichia coli	Dihydrofolate reductase	Kr	0.0051	s-1	10.1021/jm00396a019
Escherichia coli	Dihydrofolate reductase	Kr	0.048	s-1	10.1021/jm00396a019
Escherichia coli	Dihydrofolate reductase	Kr	0.2	s-1	10.1021/jm00396a019
Escherichia coli	Escherichia coli	IC50	143000.0	nM	10.1021/jm00212a010
Escherichia coli	Escherichia coli	Inhibition	nan	%	10.1021/jm00212a010
Escherichia coli	Escherichia coli	IZ	8.0	mm	10.1016/j.ejmech.2013.05.039
Escherichia coli	Escherichia coli	Log 1/C	2.7	None	10.1021/jm00150a026
Escherichia coli	Escherichia coli	Log 1/C	3.76	None	10.1021/jm00150a026
Escherichia coli	Escherichia coli	MIC	40.0	ug.mL-1	10.1021/acsmedchemlett.6b00120
Escherichia coli	Escherichia coli	MIC	640.0	ug.mL-1	10.1016/j.ejmech.2012.03.008
Escherichia coli	Escherichia coli	MIC	64000.0	nM	10.1021/acsmedchemlett.6b00120
Escherichia coli	Escherichia coli	MIC	1000000.0	nM	10.1021/acsmedchemlett.6b00120
Escherichia coli	Escherichia coli	Ratio	8.0	None	10.1016/j.ejmech.2012.03.008
Escherichia coli	Thymidylate synthase	IC50	1800.0	nM	10.1021/jm0100382
Escherichia coli	Thymidylate synthase	IC50	90000.0	nM	10.1021/jm058234m
Escherichia coli	Thymidylate synthase	IC50	90000.0	nM	10.1021/jm800244v
Escherichia coli	Thymidylate synthase	IC50	nan	nM	10.1021/jm058213s
Escherichia coli	Thymidylate synthase	IC50	nan	None	10.1021/jm000130i
Escherichia coli	Thymidylate synthase	IC50	nan	None	10.1021/jm040123k
Escherichia coli	Thymidylate synthase	IC50	nan	None	10.1021/jm040144e
Escherichia coli	Thymidylate synthase	IC50	nan	None	10.1021/jm058276a
Escherichia coli	Thymidylate synthase	IC50	nan	None	10.1021/jm701052u
Escherichia coli	Thymidylate synthase	IC50	nan	None	10.1021/jm8006933
Escherichia coli	Thymidylate synthase	IC50	nan	None	10.1021/jm900490a
Escherichia coli	Thymidylate synthase	Inhibition	nan	%	10.1021/jm010575m
Escherichia coli	Thymidylate synthase (EC 2.1.1.45) (TS) (TSase)	IC50	18000.0	nM	10.1016/j.bmc.2011.03.067
Gallus gallus	Chorioallantoic membrane	IC50	3650.0	nM	10.1016/j.bmcl.2022.128668
Gallus gallus	Dihydrofolate reductase	IC50	19.0	nM	10.1021/jm00156a026
Gallus gallus	Dihydrofolate reductase	IC50	90.0	nM	10.1021/jm00346a026
Gallus gallus	Dihydrofolate reductase	I / E100	1.0	None	10.1021/jm00355a023
Herpes simplex virus (type 1 / strain 17)	Alpha trans-inducing protein (VP16)	IC50	35879.0	nM	None
Homo sapiens	143B	IC50	8.8	nM	10.1021/jm9505122
Homo sapiens	15-hydroxyprostaglandin dehydrogenase [NAD+]	Potency	25118.9	nM	None
Homo sapiens	15-hydroxyprostaglandin dehydrogenase [NAD+]	Potency	35481.3	nM	None
Homo sapiens	5637	IC50	16.0	nM	10.1021/jm801522j
Homo sapiens	5637	IC50	293.34	nM	10.6019/CHEMBL1201861
Homo sapiens	639-V	IC50	6323.79	nM	10.6019/CHEMBL1201861
Homo sapiens	647-V	IC50	9307.22	nM	10.6019/CHEMBL1201861
Homo sapiens	697	IC50	12.57	nM	10.6019/CHEMBL1201861
Homo sapiens	769-P	IC50	45.26	nM	10.6019/CHEMBL1201861
Homo sapiens	786-0	GI50	34.04	nM	None
Homo sapiens	786-0	IC50	33.0	nM	10.1021/jm9606453
Homo sapiens	786-0	IC50	33.0	nM	10.1021/jm980477+
Homo sapiens	786-0	IC50	643.3	nM	10.6019/CHEMBL1201861
Homo sapiens	8305C	IC50	196.34	nM	10.6019/CHEMBL1201861
Homo sapiens	8505C	IC50	12212.13	nM	10.6019/CHEMBL1201861
Homo sapiens	8-MG-BA	IC50	21805.65	nM	10.6019/CHEMBL1201861
Homo sapiens	A101D	IC50	14936.26	nM	10.6019/CHEMBL1201861
Homo sapiens	A 172	IC50	1895.89	nM	10.6019/CHEMBL1201861
Homo sapiens	A204	IC50	1084.08	nM	10.6019/CHEMBL1201861
Homo sapiens	A2058	IC50	1987.73	nM	10.6019/CHEMBL1201861
Homo sapiens	A253 cell line	EC50	13.0	nM	10.1021/jm00019a009
Homo sapiens	A253 cell line	EC50	14.5	nM	10.1021/jm000130i
Homo sapiens	A253 cell line	EC50	17.0	nM	10.1021/jm00012a016
Homo sapiens	A253 cell line	EC50	19.0	nM	10.1021/jm0100382
Homo sapiens	A253 cell line	EC50	3000.0	nM	10.1021/jm00022a015
Homo sapiens	A2780	IC50	54.54	nM	10.6019/CHEMBL1201861
Homo sapiens	A-375	IC50	22.0	nM	10.1016/j.bmcl.2016.04.096
Homo sapiens	A-375	IC50	9816.46	nM	10.6019/CHEMBL1201861
Homo sapiens	A388	IC50	1605.0	nM	10.6019/CHEMBL1201861
Homo sapiens	A3-KAW	IC50	8.923	nM	10.6019/CHEMBL1201861
Homo sapiens	A-427	IC50	5520.0	nM	10.1021/jm801522j
Homo sapiens	A-427	IC50	16184.22	nM	10.6019/CHEMBL1201861
Homo sapiens	A-431	IC50	2197.1	nM	10.6019/CHEMBL1201861
Homo sapiens	A498	GI50	4775.29	nM	None
Homo sapiens	A498	IC50	22.0	nM	10.1016/j.bmcl.2016.04.096
Homo sapiens	A498	IC50	1000.0	nM	10.1021/jm980477+
Homo sapiens	A498	IC50	9373.67	nM	10.6019/CHEMBL1201861
Homo sapiens	A4-Fuk	IC50	38.23	nM	10.6019/CHEMBL1201861
Homo sapiens	A549	Activity	0.0	%	10.1016/j.ejmech.2017.07.002
Homo sapiens	A549	Activity	14.3	%	10.1016/j.bmc.2009.11.065
Homo sapiens	A549	Activity	16.0	%	10.1016/j.bmc.2009.11.065
Homo sapiens	A549	Activity	38.0	%	10.1016/j.ejmech.2017.07.002
Homo sapiens	A549	Activity	62.0	%	10.1016/j.ejmech.2017.07.002
Homo sapiens	A549	Activity	77.3	%	10.1016/j.bmc.2009.11.065
Homo sapiens	A549	Activity	96.6	%	10.1016/j.bmc.2009.11.065
Homo sapiens	A549	GI50	14.0	nM	10.1016/j.ejmech.2017.07.002
Homo sapiens	A549	GI50	34.51	nM	None
Homo sapiens	A549	IC50	0.005	ug.mL-1	10.1021/np990140q
Homo sapiens	A549	IC50	0.035	ug.mL-1	10.1021/jm00106a012
Homo sapiens	A549	IC50	5.0	nM	10.1016/j.bmc.2010.05.072
Homo sapiens	A549	IC50	13.0	nM	10.1016/j.ejmech.2015.01.055
Homo sapiens	A549	IC50	13.5	nM	10.1016/j.ejmech.2017.01.033
Homo sapiens	A549	IC50	14.0	nM	10.1016/j.ejmech.2020.112113
Homo sapiens	A549	IC50	20.0	nM	10.1016/j.bmc.2006.11.017
Homo sapiens	A549	IC50	22.0	nM	10.1016/j.bmcl.2016.04.096
Homo sapiens	A549	IC50	23.0	nM	10.1021/jm9606453
Homo sapiens	A549	IC50	31.0	nM	10.1021/jm9505122
Homo sapiens	A549	IC50	33.0	nM	10.1021/jm980477+
Homo sapiens	A549	IC50	37.4	nM	10.1016/j.bmc.2009.11.065
Homo sapiens	A549	IC50	39.33	ug.mL-1	10.1016/j.bmc.2018.12.003
Homo sapiens	A549	IC50	100.0	nM	10.1016/j.bmc.2006.11.017
Homo sapiens	A549	IC50	990.0	nM	10.1016/j.ejmech.2016.03.032
Homo sapiens	A549	IC50	990.0	nM	10.1016/j.ejmech.2019.06.013
Homo sapiens	A549	IC50	11589.88	nM	10.6019/CHEMBL1201861
Homo sapiens	A673	IC50	1605.3	nM	10.6019/CHEMBL1201861
Homo sapiens	A704	IC50	22814.47	nM	10.6019/CHEMBL1201861
Homo sapiens	ABC-1	IC50	21149.62	nM	10.6019/CHEMBL1201861
Homo sapiens	Acetylcholinesterase	IC50	nan	None	None
Homo sapiens	Acetylcholinesterase	Ki	nan	None	None
Homo sapiens	ACHN	GI50	38.55	nM	None
Homo sapiens	ACHN	IC50	40.0	nM	10.1021/jm9606453
Homo sapiens	ACHN	IC50	40.0	nM	10.1021/jm980477+
Homo sapiens	ACHN	IC50	85.26	nM	10.6019/CHEMBL1201861
Homo sapiens	ACN	IC50	16378.87	nM	10.6019/CHEMBL1201861
Homo sapiens	Adenosine A1 receptor	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Adenosine A1 receptor	IC50	nan	None	None
Homo sapiens	Adenosine A1 receptor	Ki	nan	None	None
Homo sapiens	Adenosine A2a receptor	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Adenosine A2a receptor	IC50	nan	None	None
Homo sapiens	Adenosine A2a receptor	Ki	nan	None	None
Homo sapiens	Adenosine A3 receptor	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Adenosine A3 receptor	IC50	nan	None	None
Homo sapiens	Adenosine A3 receptor	Ki	nan	None	None
Homo sapiens	AICAR transformylase	IC50	20000.0	nM	10.1021/jm00396a022
Homo sapiens	AICAR transformylase	Ki	880.0	nM	10.1016/j.bmc.2021.116093
Homo sapiens	Aldehyde dehydrogenase 1A1	Potency	22387.2	nM	None
Homo sapiens	Aldehyde dehydrogenase 1A1	Potency	35481.3	nM	None
Homo sapiens	Aldehyde dehydrogenase 1A1	Potency	39810.7	nM	None
Homo sapiens	ALL-PO	IC50	5.858	nM	10.6019/CHEMBL1201861
Homo sapiens	Alpha-1a adrenergic receptor	AC50	10000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Alpha-1a adrenergic receptor	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Alpha-1d adrenergic receptor	IC50	nan	None	None
Homo sapiens	Alpha-1d adrenergic receptor	Ki	nan	None	None
Homo sapiens	Alpha-2a adrenergic receptor	AC50	10000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Alpha-2a adrenergic receptor	IC50	nan	None	None
Homo sapiens	Alpha-2a adrenergic receptor	Ki	nan	None	None
Homo sapiens	Alpha-2b adrenergic receptor	AC50	10000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Alpha-2b adrenergic receptor	IC50	nan	None	None
Homo sapiens	Alpha-2b adrenergic receptor	Ki	nan	None	None
Homo sapiens	Alpha-2c adrenergic receptor	AC50	10000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Alpha-2c adrenergic receptor	IC50	nan	None	None
Homo sapiens	Alpha-2c adrenergic receptor	Ki	nan	None	None
Homo sapiens	Alpha-galactosidase A	Potency	14125.4	nM	None
Homo sapiens	Alpha-galactosidase A	Potency	25118.9	nM	None
Homo sapiens	AM-38	IC50	603.87	nM	10.6019/CHEMBL1201861
Homo sapiens	AN3-CA	IC50	9489.0	nM	10.6019/CHEMBL1201861
Homo sapiens	Angiotensin II type 2 (AT-2) receptor	IC50	nan	None	None
Homo sapiens	Angiotensin II type 2 (AT-2) receptor	Ki	nan	None	None
Homo sapiens	Arachidonate 12-lipoxygenase	Potency	39810.7	nM	None
Homo sapiens	Arachidonate 15-lipoxygenase	Potency	10000.0	nM	None
Homo sapiens	ASPC1	IC50	266.22	nM	10.6019/CHEMBL1201861
Homo sapiens	ATN-1	IC50	3.924	nM	10.6019/CHEMBL1201861
Homo sapiens	ATPase family AAA domain-containing protein 5	Potency	259.2	nM	None
Homo sapiens	ATP-binding cassette sub-family C member 11	Km	957000.0	nM	10.1124/mol.104.007138
Homo sapiens	ATP-binding cassette sub-family G member 2	Activity	nan	None	10.1038/nrd3028
Homo sapiens	ATP-binding cassette sub-family G member 2	Activity	nan	None	10.1074/jbc.m212399200
Homo sapiens	ATP-binding cassette sub-family G member 2	Activity	nan	None	10.1158/0008-5472.can-03-4062
Homo sapiens	ATP-binding cassette sub-family G member 2	Km	680000.0	nM	None
Homo sapiens	ATP-binding cassette sub-family G member 2	Km	1300000.0	nM	None
Homo sapiens	ATP-binding cassette sub-family G member 2	Km	5700000.0	nM	10.1042/bj20030150
Homo sapiens	AU565	IC50	61.34	nM	10.6019/CHEMBL1201861
Homo sapiens	BALL-1	IC50	1186.96	nM	10.6019/CHEMBL1201861
Homo sapiens	BB30-HNC	IC50	94.28	nM	10.6019/CHEMBL1201861
Homo sapiens	BB49-HNC	IC50	10186.42	nM	10.6019/CHEMBL1201861
Homo sapiens	BB65-RCC	IC50	7085.95	nM	10.6019/CHEMBL1201861
Homo sapiens	BCPAP	IC50	43.1	nM	10.6019/CHEMBL1201861
Homo sapiens	BE-13	IC50	38.75	nM	10.6019/CHEMBL1201861
Homo sapiens	Becker	IC50	12792.55	nM	10.6019/CHEMBL1201861
Homo sapiens	Bel-7402	IC50	82300.0	nM	10.1016/j.ejmech.2008.04.017
Homo sapiens	BEN	IC50	9704.11	nM	10.6019/CHEMBL1201861
Homo sapiens	Beta-1 adrenergic receptor	AC50	10000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Beta-1 adrenergic receptor	IC50	nan	None	None
Homo sapiens	Beta-1 adrenergic receptor	Ki	nan	None	None
Homo sapiens	Beta-2 adrenergic receptor	AC50	10000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Beta-2 adrenergic receptor	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Beta-2 adrenergic receptor	IC50	nan	None	None
Homo sapiens	Beta-2 adrenergic receptor	Ki	nan	None	None
Homo sapiens	Beta-3 adrenergic receptor	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Beta-3 adrenergic receptor	IC50	nan	None	None
Homo sapiens	Beta-3 adrenergic receptor	Ki	nan	None	None
Homo sapiens	BFTC-905	IC50	9016.06	nM	10.6019/CHEMBL1201861
Homo sapiens	BFTC-909	IC50	9208.64	nM	10.6019/CHEMBL1201861
Homo sapiens	BGC-823	IC50	110.0	nM	10.1016/j.ejmech.2008.04.017
Homo sapiens	BHT-101	IC50	26644.29	nM	10.6019/CHEMBL1201861
Homo sapiens	BHY	IC50	5725.8	nM	10.6019/CHEMBL1201861
Homo sapiens	Bile acid receptor FXR	Potency	158.5	nM	None
Homo sapiens	Bile salt export pump	IC50	133000.0	nM	10.1093/toxsci/kft176
Homo sapiens	Bile salt export pump	IC50	135000.0	nM	10.1093/toxsci/kfq269
Homo sapiens	Bile salt export pump	IC50	1000000.0	nM	10.1124/dmd.111.040758
Homo sapiens	Bile salt export pump	IC50	1000000.0	nM	10.1124/dmd.112.047068
Homo sapiens	Bloom syndrome protein	Potency	19952.6	nM	None
Homo sapiens	BPH-1	IC50	772.41	nM	10.6019/CHEMBL1201861
Homo sapiens	Bradykinin B1 receptor	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Bradykinin B2 receptor	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Bradykinin B2 receptor	IC50	nan	None	None
Homo sapiens	Bradykinin B2 receptor	Ki	nan	None	None
Homo sapiens	BT-20	IC50	1350.19	nM	10.6019/CHEMBL1201861
Homo sapiens	BT-474	IC50	12541.84	nM	10.6019/CHEMBL1201861
Homo sapiens	BT-549	GI50	69502.43	nM	None
Homo sapiens	BT-549	IC50	1000.0	nM	10.1021/jm980477+
Homo sapiens	BT-549	Inhibition	53.1	%	10.1016/j.ejmech.2019.111965
Homo sapiens	BV-173	IC50	6.349	nM	10.6019/CHEMBL1201861
Homo sapiens	BXPC-3	IC50	4406.82	nM	10.6019/CHEMBL1201861
Homo sapiens	C2BBe1	IC50	996.16	nM	10.6019/CHEMBL1201861
Homo sapiens	C32	IC50	2924.7	nM	10.6019/CHEMBL1201861
Homo sapiens	C-33-A	IC50	10685.38	nM	10.6019/CHEMBL1201861
Homo sapiens	C3A	IC50	2988.32	nM	10.6019/CHEMBL1201861
Homo sapiens	C8166	IC50	224.12	nM	10.6019/CHEMBL1201861
Homo sapiens	Ca9-22	IC50	3404.94	nM	10.6019/CHEMBL1201861
Homo sapiens	Caco-2	EC50	1100.0	nM	10.1016/j.bmcl.2010.07.024
Homo sapiens	Caco-2	IC50	0.32	ug.mL-1	10.1007/s00044-013-0773-3
Homo sapiens	Caco-2	IC50	0.32	ug.mL-1	10.1016/j.ejmech.2010.08.063
Homo sapiens	Caco-2	logPapp	-5.92	None	10.1016/j.bmc.2009.08.022
Homo sapiens	Caco-2	logPapp	-5.92	None	10.1016/j.bmc.2011.03.011
Homo sapiens	CAKI-1	GI50	61.38	nM	None
Homo sapiens	CAKI-1	IC50	3.0	ug.mL-1	10.1021/jm00131a003
Homo sapiens	CAKI-1	IC50	3.3	ug.mL-1	10.1021/jm00131a003
Homo sapiens	CAKI-1	IC50	3.4	ug.mL-1	10.1021/jm00131a003
Homo sapiens	CAKI-1	IC50	4.5	ug.mL-1	10.1021/jm00131a003
Homo sapiens	CAKI-1	IC50	25.0	ug.mL-1	10.1021/jm00131a003
Homo sapiens	CAKI-1	IC50	60.0	ug.mL-1	10.1021/jm0701977
Homo sapiens	CAKI-1	IC50	671.49	nM	10.6019/CHEMBL1201861
Homo sapiens	CAL-120	IC50	10838.88	nM	10.6019/CHEMBL1201861
Homo sapiens	CAL-12T	IC50	8430.14	nM	10.6019/CHEMBL1201861
Homo sapiens	CAL-27	IC50	9644.3	nM	10.6019/CHEMBL1201861
Homo sapiens	CAL-33	IC50	7677.12	nM	10.6019/CHEMBL1201861
Homo sapiens	CAL-39	IC50	17407.18	nM	10.6019/CHEMBL1201861
Homo sapiens	CAL-51	IC50	4532.64	nM	10.6019/CHEMBL1201861
Homo sapiens	CAL-54	IC50	2791.73	nM	10.6019/CHEMBL1201861
Homo sapiens	CAL-62	IC50	3175.41	nM	10.6019/CHEMBL1201861
Homo sapiens	CAL-72	IC50	415.94	nM	10.6019/CHEMBL1201861
Homo sapiens	CAL-85-1	IC50	10940.48	nM	10.6019/CHEMBL1201861
Homo sapiens	Calcitonin receptor	IC50	nan	None	None
Homo sapiens	Calcitonin receptor	Ki	nan	None	None
Homo sapiens	Calu-3	IC50	15299.19	nM	10.6019/CHEMBL1201861
Homo sapiens	Calu-6	IC50	552.72	nM	10.6019/CHEMBL1201861
Homo sapiens	CAMA-1	IC50	3937.34	nM	10.6019/CHEMBL1201861
Homo sapiens	Canalicular multispecific organic anion transporter 1	Activity	130.0	%	10.1021/jm7015683
Homo sapiens	Canalicular multispecific organic anion transporter 1	Activity	nan	None	10.1038/nrd3028
Homo sapiens	Canalicular multispecific organic anion transporter 1	Activity	nan	None	10.1124/mol.57.4.760
Homo sapiens	Canalicular multispecific organic anion transporter 1	Activity	nan	None	None
Homo sapiens	Canalicular multispecific organic anion transporter 1	FC	-0.2	None	10.1124/dmd.110.034629
Homo sapiens	Canalicular multispecific organic anion transporter 1	IC50	133000.0	nM	10.1093/toxsci/kft176
Homo sapiens	Canalicular multispecific organic anion transporter 2	Activity	nan	None	10.1038/nrd3028
Homo sapiens	Canalicular multispecific organic anion transporter 2	IC50	133000.0	nM	10.1093/toxsci/kft176
Homo sapiens	Cannabinoid CB1 receptor	AC50	10000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Cannabinoid CB1 receptor	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Cannabinoid CB1 receptor	IC50	nan	None	None
Homo sapiens	Cannabinoid CB1 receptor	Ki	nan	None	None
Homo sapiens	CAPAN-1	IC50	6096.15	nM	10.6019/CHEMBL1201861
Homo sapiens	Capan-2	IC50	2282.26	nM	10.6019/CHEMBL1201861
Homo sapiens	CaR-1	IC50	13216.83	nM	10.6019/CHEMBL1201861
Homo sapiens	Carbonic anhydrase II	IC50	nan	None	None
Homo sapiens	Carbonic anhydrase II	Ki	nan	None	None
Homo sapiens	CAS-1	IC50	16566.67	nM	10.6019/CHEMBL1201861
Homo sapiens	Ca-Ski	IC50	373.19	nM	10.6019/CHEMBL1201861
Homo sapiens	Caspase-1	IC50	nan	None	None
Homo sapiens	Caspase-1	Ki	nan	None	None
Homo sapiens	Caspase-1	Potency	15848.9	nM	None
Homo sapiens	Caspase-7	Potency	15848.9	nM	None
Homo sapiens	Cathepsin G	IC50	nan	None	None
Homo sapiens	Cathepsin G	Ki	nan	None	None
Homo sapiens	C-C chemokine receptor type 2	IC50	nan	None	None
Homo sapiens	C-C chemokine receptor type 2	Ki	nan	None	None
Homo sapiens	C-C chemokine receptor type 4	IC50	nan	None	None
Homo sapiens	C-C chemokine receptor type 4	Ki	nan	None	None
Homo sapiens	C-C chemokine receptor type 5	IC50	nan	None	None
Homo sapiens	C-C chemokine receptor type 5	Ki	nan	None	None
Homo sapiens	CCRF-CEM	Activity	5.0	%	10.1021/jm058234m
Homo sapiens	CCRF-CEM	Activity	10.0	%	10.1021/jm058276a
Homo sapiens	CCRF-CEM	Activity	11.0	%	10.1021/jm040123k
Homo sapiens	CCRF-CEM	Activity	11.0	%	10.1021/jm058276a
Homo sapiens	CCRF-CEM	Activity	11.0	%	10.1021/jm070165j
Homo sapiens	CCRF-CEM	Activity	12.0	%	10.1021/jm058234m
Homo sapiens	CCRF-CEM	Activity	12.5	%	10.1021/jm040123k
Homo sapiens	CCRF-CEM	Activity	13.0	%	10.1021/jm040123k
Homo sapiens	CCRF-CEM	Activity	13.0	%	10.1021/jm070165j
Homo sapiens	CCRF-CEM	Activity	13.5	%	10.1021/jm040123k
Homo sapiens	CCRF-CEM	Activity	14.0	%	10.1021/jm070165j
Homo sapiens	CCRF-CEM	Activity	15.5	%	10.1021/jm040123k
Homo sapiens	CCRF-CEM	Activity	16.0	%	10.1021/jm040123k
Homo sapiens	CCRF-CEM	Activity	44.0	%	10.1021/jm058276a
Homo sapiens	CCRF-CEM	Activity	73.5	%	10.1021/jm040123k
Homo sapiens	CCRF-CEM	Activity	74.0	%	10.1021/jm070165j
Homo sapiens	CCRF-CEM	Activity	74.5	%	10.1021/jm040123k
Homo sapiens	CCRF-CEM	Activity	90.0	%	10.1021/jm058234m
Homo sapiens	CCRF-CEM	Activity	95.0	%	10.1021/jm058234m
Homo sapiens	CCRF-CEM	Activity	96.0	%	10.1021/jm058234m
Homo sapiens	CCRF-CEM	Activity	99.0	%	10.1021/jm058276a
Homo sapiens	CCRF-CEM	Activity	101.0	%	10.1021/jm058276a
Homo sapiens	CCRF-CEM	EC50	7.9	nM	10.1021/jm040123k
Homo sapiens	CCRF-CEM	EC50	8.0	nM	10.1021/jm9705420
Homo sapiens	CCRF-CEM	EC50	8.2	nM	10.1021/jm040123k
Homo sapiens	CCRF-CEM	EC50	12.0	nM	10.1021/jm0202369
Homo sapiens	CCRF-CEM	EC50	12.5	nM	10.1021/jm058234m
Homo sapiens	CCRF-CEM	EC50	12.5	nM	10.1021/jm800244v
Homo sapiens	CCRF-CEM	EC50	13.0	nM	10.1021/jm058213s
Homo sapiens	CCRF-CEM	EC50	13.3	nM	10.1021/jm070165j
Homo sapiens	CCRF-CEM	EC50	13.7	nM	10.1021/jm0203534
Homo sapiens	CCRF-CEM	EC50	13.8	nM	10.1021/jm000200l
Homo sapiens	CCRF-CEM	EC50	14.0	nM	10.1021/jm00019a009
Homo sapiens	CCRF-CEM	EC50	14.0	nM	10.1021/jm00022a015
Homo sapiens	CCRF-CEM	EC50	14.0	nM	10.1021/jm0100382
Homo sapiens	CCRF-CEM	EC50	14.0	nM	10.1021/jm058276a
Homo sapiens	CCRF-CEM	EC50	14.3	nM	10.1021/jm9705420
Homo sapiens	CCRF-CEM	EC50	14.4	nM	10.1021/jm000130i
Homo sapiens	CCRF-CEM	EC50	14.5	nM	10.1021/jm00012a016
Homo sapiens	CCRF-CEM	EC50	14.5	nM	10.1021/jm010575m
Homo sapiens	CCRF-CEM	EC50	14.5	nM	10.1021/jm058213s
Homo sapiens	CCRF-CEM	EC50	14.5	nM	10.1021/jm058234m
Homo sapiens	CCRF-CEM	EC50	15.0	nM	10.1021/jm0100382
Homo sapiens	CCRF-CEM	EC50	15.5	nM	10.1021/jm000200l
Homo sapiens	CCRF-CEM	EC50	15.7	nM	10.1021/jm070165j
Homo sapiens	CCRF-CEM	EC50	16.0	nM	10.1021/jm00034a015
Homo sapiens	CCRF-CEM	EC50	16.5	nM	10.1021/jm040144e
Homo sapiens	CCRF-CEM	EC50	17.0	nM	10.1021/jm058276a
Homo sapiens	CCRF-CEM	EC50	17.5	nM	10.1021/jm040144e
Homo sapiens	CCRF-CEM	EC50	18.0	nM	10.1021/jm00019a009
Homo sapiens	CCRF-CEM	EC50	18.0	nM	10.1021/jm00022a015
Homo sapiens	CCRF-CEM	EC50	410.0	nM	10.1021/jm070165j
Homo sapiens	CCRF-CEM	EC50	567.0	nM	10.1021/jm9705420
Homo sapiens	CCRF-CEM	EC50	595.0	nM	10.1021/jm00012a016
Homo sapiens	CCRF-CEM	EC50	600.0	nM	10.1021/jm0100382
Homo sapiens	CCRF-CEM	EC50	615.0	nM	10.1021/jm058234m
Homo sapiens	CCRF-CEM	EC50	620.0	nM	10.1021/jm058213s
Homo sapiens	CCRF-CEM	EC50	660.0	nM	10.1021/jm000200l
Homo sapiens	CCRF-CEM	EC50	660.0	nM	10.1021/jm040123k
Homo sapiens	CCRF-CEM	EC50	1500.0	nM	10.1021/jm040123k
Homo sapiens	CCRF-CEM	EC50	1500.0	nM	10.1021/jm058213s
Homo sapiens	CCRF-CEM	EC50	1500.0	nM	10.1021/jm058234m
Homo sapiens	CCRF-CEM	EC50	1900.0	nM	10.1021/jm0100382
Homo sapiens	CCRF-CEM	EC50	1950.0	nM	10.1021/jm070165j
Homo sapiens	CCRF-CEM	EC50	2030.0	nM	10.1021/jm000200l
Homo sapiens	CCRF-CEM	EC50	2760.0	nM	10.1021/jm00034a015
Homo sapiens	CCRF-CEM	EC50	3100.0	nM	10.1021/jm00012a016
Homo sapiens	CCRF-CEM	ED50	13.7	nM	10.1021/jm950514m
Homo sapiens	CCRF-CEM	ED50	14.5	nM	10.1021/jm960046w
Homo sapiens	CCRF-CEM	ED50	15.5	nM	10.1021/jm950514m
Homo sapiens	CCRF-CEM	ED50	655.0	nM	10.1021/jm950514m
Homo sapiens	CCRF-CEM	ED50	2550.0	nM	10.1021/jm950514m
Homo sapiens	CCRF-CEM	GI50	29.58	nM	None
Homo sapiens	CCRF-CEM	GI50	39.81	nM	10.1016/j.ejmech.2007.03.035
Homo sapiens	CCRF-CEM	IC50	0.004	ug.mL-1	10.1021/jm990411u
Homo sapiens	CCRF-CEM	IC50	10.5	nM	10.1021/jm00040a008
Homo sapiens	CCRF-CEM	IC50	25.0	nM	10.1021/jm00371a009
Homo sapiens	CCRF-CEM	IC50	29.0	nM	10.1021/jm980477+
Homo sapiens	CCRF-CEM	IC50	32.0	nM	10.1021/jm00402a014
Homo sapiens	CCRF-CEM	IC50	32.0	nM	10.1021/jm50001a021
Homo sapiens	CCRF-CEM	IC50	695.81	nM	10.6019/CHEMBL1201861
Homo sapiens	CCRF-CEM	IC50	2550.0	nM	10.1021/jm00040a008
Homo sapiens	CCRF-CEM	IC50	6600.0	nM	10.1021/jm00402a014
Homo sapiens	CCRF-CEM	IC50	6600.0	nM	10.1021/jm50001a021
Homo sapiens	CCRF-CEM	ID50	0.003	ug ml-1	10.1021/jm00200a005
Homo sapiens	CCRF-CEM	ID50	0.003	ug ml-1	10.1021/jm00217a012
Homo sapiens	CCRF-CEM	ID50	0.003	uM	10.1021/jm00137a016
Homo sapiens	CCRF-CEM	ID50	0.006	10'-6 mol/L	10.1021/jm00202a013
Homo sapiens	CCRF-CEM	ID50	0.018	ug ml-1	10.1021/jm00220a019
Homo sapiens	CCRF-CEM	ID50	0.02	ug ml-1	10.1021/jm00193a022
Homo sapiens	CCRF-CEM	ID50	0.02	ug ml-1	10.1021/jm00193a023
Homo sapiens	CCRF-CEM	Inhibition	10.0	%	10.1021/jm040144e
Homo sapiens	CCRF-CEM	Ki	4480.0	nM	10.1021/jm00040a008
Homo sapiens	CCRF-CEM	Ki	9740.0	nM	10.1021/jm00040a008
Homo sapiens	CCRF-CEM	Relative	18.0	uM	10.1021/jm058213s
Homo sapiens	CCRF-CEM	Relative activity	38.0	None	10.1021/jm00105a035
Homo sapiens	CCRF-CEM	Relative growth	2.8	None	10.1021/jm0202369
Homo sapiens	CCRF-CEM	Relative growth	3.7	None	10.1021/jm0202369
Homo sapiens	CCRF-CEM	Relative growth	11.5	None	10.1021/jm000200l
Homo sapiens	CCRF-CEM	Relative growth	15.0	None	10.1021/jm000200l
Homo sapiens	CCRF-CEM	Relative growth	16.0	%	10.1021/jm058213s
Homo sapiens	CCRF-CEM	Relative growth	17.0	%	10.1021/jm058213s
Homo sapiens	CCRF-CEM	Relative growth	18.0	%	10.1021/jm058213s
Homo sapiens	CCRF-CEM	Relative growth	18.5	None	10.1021/jm000200l
Homo sapiens	CCRF-CEM	Relative growth	74.0	None	10.1021/jm0202369
Homo sapiens	CCRF-CEM	Relative growth	75.0	%	10.1021/jm058213s
Homo sapiens	CCRF-CEM	Relative growth	75.0	None	10.1021/jm0202369
Homo sapiens	CCRF-CEM	Relative growth	77.0	None	10.1021/jm0202369
Homo sapiens	CCRF-CEM	Relative growth	82.0	%	10.1021/jm058213s
Homo sapiens	CCRF-CEM	Relative growth	91.0	None	10.1021/jm0202369
Homo sapiens	CCRF-CEM	Relative growth	91.5	None	10.1021/jm000200l
Homo sapiens	CCRF-CEM	Relative growth	92.0	None	10.1021/jm0202369
Homo sapiens	CCRF-CEM	Relative growth	95.0	None	10.1021/jm0202369
Homo sapiens	Cellular tumor antigen p53	Potency	100.0	nM	None
Homo sapiens	Cellular tumor antigen p53	Potency	316.2	nM	None
Homo sapiens	CFPAC-1	IC50	689.55	nM	10.6019/CHEMBL1201861
Homo sapiens	CGTH-W-1	IC50	31.21	nM	10.6019/CHEMBL1201861
Homo sapiens	ChaGo-K-1	IC50	7738.26	nM	10.6019/CHEMBL1201861
Homo sapiens	CHL-1	IC50	209.51	nM	10.6019/CHEMBL1201861
Homo sapiens	Cholecystokinin A receptor	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Cholecystokinin A receptor	IC50	nan	None	None
Homo sapiens	Cholecystokinin A receptor	Ki	nan	None	None
Homo sapiens	Cholecystokinin B receptor	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	CHP-212	IC50	7847.41	nM	10.6019/CHEMBL1201861
Homo sapiens	Chromobox protein homolog 1	Potency	56234.1	nM	None
Homo sapiens	COLO 205	GI50	1185.77	nM	None
Homo sapiens	COLO 205	IC50	870.0	nM	10.1021/jm980477+
Homo sapiens	COLO 205	IC50	3270.0	nM	10.1016/j.bmcl.2013.07.059
Homo sapiens	COLO-320-HSR	IC50	52.38	nM	10.6019/CHEMBL1201861
Homo sapiens	COLO-668	IC50	498.56	nM	10.6019/CHEMBL1201861
Homo sapiens	COLO-678	IC50	11979.96	nM	10.6019/CHEMBL1201861
Homo sapiens	COLO-679	IC50	18583.67	nM	10.6019/CHEMBL1201861
Homo sapiens	COLO-680N	IC50	19598.22	nM	10.6019/CHEMBL1201861
Homo sapiens	COLO-684	IC50	37.55	nM	10.6019/CHEMBL1201861
Homo sapiens	COLO-741	IC50	162.12	nM	10.6019/CHEMBL1201861
Homo sapiens	COLO-792	IC50	16965.94	nM	10.6019/CHEMBL1201861
Homo sapiens	COLO-800	IC50	123.72	nM	10.6019/CHEMBL1201861
Homo sapiens	COLO-824	IC50	14289.74	nM	10.6019/CHEMBL1201861
Homo sapiens	COLO-829	IC50	1429.79	nM	10.6019/CHEMBL1201861
Homo sapiens	COR-L105	IC50	16863.49	nM	10.6019/CHEMBL1201861
Homo sapiens	COR-L23	IC50	121.92	nM	10.6019/CHEMBL1201861
Homo sapiens	Corticotropin releasing factor receptor 1	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Corticotropin releasing factor receptor 2	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	CP50-MEL-B	IC50	12292.46	nM	10.6019/CHEMBL1201861
Homo sapiens	CTB-1	IC50	16.23	nM	10.6019/CHEMBL1201861
Homo sapiens	CTV-1	IC50	77.1	nM	10.6019/CHEMBL1201861
Homo sapiens	CW-2	IC50	15777.17	nM	10.6019/CHEMBL1201861
Homo sapiens	CWR22R	IC50	536.88	nM	10.6019/CHEMBL1201861
Homo sapiens	Cyclooxygenase-1	IC50	nan	None	None
Homo sapiens	Cyclooxygenase-1	Ki	nan	None	None
Homo sapiens	Cyclooxygenase-2	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Cyclooxygenase-2	IC50	nan	None	None
Homo sapiens	Cyclooxygenase-2	Ki	nan	None	None
Homo sapiens	Cysteinyl leukotriene receptor 1	IC50	nan	None	None
Homo sapiens	Cysteinyl leukotriene receptor 1	Ki	nan	None	None
Homo sapiens	Cytochrome P450 1A2	AC50	nan	None	None
Homo sapiens	Cytochrome P450 1A2	IC50	nan	None	None
Homo sapiens	Cytochrome P450 1A2	Inhibition	nan	%	10.1021/tx300075j
Homo sapiens	Cytochrome P450 1A2	Ki	nan	None	None
Homo sapiens	Cytochrome P450 2A6	IC50	nan	None	None
Homo sapiens	Cytochrome P450 2A6	Ki	nan	None	None
Homo sapiens	Cytochrome P450 2C19	AC50	nan	None	None
Homo sapiens	Cytochrome P450 2C19	IC50	nan	None	None
Homo sapiens	Cytochrome P450 2C19	Inhibition	nan	%	10.1021/tx300075j
Homo sapiens	Cytochrome P450 2C19	Ki	nan	None	None
Homo sapiens	Cytochrome P450 2C9	AC50	nan	None	None
Homo sapiens	Cytochrome P450 2C9	IC50	nan	None	None
Homo sapiens	Cytochrome P450 2C9	Inhibition	nan	%	10.1021/tx300075j
Homo sapiens	Cytochrome P450 2C9	Ki	nan	None	None
Homo sapiens	Cytochrome P450 2D6	AC50	nan	None	None
Homo sapiens	Cytochrome P450 2D6	FC	1.0	None	10.1016/j.bmcl.2016.06.088
Homo sapiens	Cytochrome P450 2D6	IC50	nan	None	None
Homo sapiens	Cytochrome P450 2D6	Inhibition	nan	%	10.1021/tx300075j
Homo sapiens	Cytochrome P450 2D6	Ki	nan	None	None
Homo sapiens	Cytochrome P450 2E1	IC50	nan	None	None
Homo sapiens	Cytochrome P450 2E1	Ki	nan	None	None
Homo sapiens	Cytochrome P450 3A4	AC50	nan	None	None
Homo sapiens	Cytochrome P450 3A4	FC	1.0	None	10.1016/j.bmcl.2016.06.088
Homo sapiens	Cytochrome P450 3A4	IC50	nan	None	None
Homo sapiens	Cytochrome P450 3A4	Inhibition	nan	%	10.1021/tx300075j
Homo sapiens	Cytochrome P450 3A4	Ki	nan	None	None
Homo sapiens	D-247MG	IC50	15592.84	nM	10.6019/CHEMBL1201861
Homo sapiens	D-263MG	IC50	3983.99	nM	10.6019/CHEMBL1201861
Homo sapiens	D283 Med	IC50	7704.6	nM	10.6019/CHEMBL1201861
Homo sapiens	D-336MG	IC50	11889.84	nM	10.6019/CHEMBL1201861
Homo sapiens	D-392MG	IC50	158.09	nM	10.6019/CHEMBL1201861
Homo sapiens	D-423MG	IC50	23828.49	nM	10.6019/CHEMBL1201861
Homo sapiens	D-502MG	IC50	22946.15	nM	10.6019/CHEMBL1201861
Homo sapiens	D54 cell line	IC50	16.0	nM	10.1021/jm9505122
Homo sapiens	D-566MG	IC50	21868.98	nM	10.6019/CHEMBL1201861
Homo sapiens	DAN-G	IC50	77.0	nM	10.1021/jm801522j
Homo sapiens	Daoy	IC50	12683.3	nM	10.6019/CHEMBL1201861
Homo sapiens	DB	IC50	21.28	nM	10.6019/CHEMBL1201861
Homo sapiens	DBTRG-05MG	IC50	171.18	nM	10.6019/CHEMBL1201861
Homo sapiens	DEL	IC50	3.119	nM	10.6019/CHEMBL1201861
Homo sapiens	Delta opioid receptor	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Delta opioid receptor	IC50	nan	None	None
Homo sapiens	Delta opioid receptor	Ki	nan	None	None
Homo sapiens	Detroit 562	IC50	6924.74	nM	10.6019/CHEMBL1201861
Homo sapiens	Dihydrofolate reductase	IC50	0.6	nM	10.1021/jm950515e
Homo sapiens	Dihydrofolate reductase	IC50	0.7	nM	10.1021/jm00019a009
Homo sapiens	Dihydrofolate reductase	IC50	0.72	nM	10.1021/jm950515e
Homo sapiens	Dihydrofolate reductase	IC50	0.82	nM	10.1021/jm960046w
Homo sapiens	Dihydrofolate reductase	IC50	1.0	nM	10.1021/jm061475p
Homo sapiens	Dihydrofolate reductase	IC50	1.18	nM	10.1021/jm950515e
Homo sapiens	Dihydrofolate reductase	IC50	1.2	nM	10.1021/jm00358a030
Homo sapiens	Dihydrofolate reductase	IC50	1.4	nM	10.1021/jm950515e
Homo sapiens	Dihydrofolate reductase	IC50	1.5	nM	10.1021/jm00192a024
Homo sapiens	Dihydrofolate reductase	IC50	1.6	nM	10.1021/acsmedchemlett.5b00367
Homo sapiens	Dihydrofolate reductase	IC50	1.7	nM	10.1021/jm400086g
Homo sapiens	Dihydrofolate reductase	IC50	1.97	nM	10.1016/j.bmc.2019.02.053
Homo sapiens	Dihydrofolate reductase	IC50	2.0	nM	10.1021/jm0009639
Homo sapiens	Dihydrofolate reductase	IC50	2.1	nM	10.1016/j.ejmech.2013.04.017
Homo sapiens	Dihydrofolate reductase	IC50	2.7	nM	10.1021/jm00087a012
Homo sapiens	Dihydrofolate reductase	IC50	2.7	nM	10.1021/jm00159a032
Homo sapiens	Dihydrofolate reductase	IC50	3.0	nM	10.1016/j.ejmech.2020.112986
Homo sapiens	Dihydrofolate reductase	IC50	3.0	nM	10.1039/C3MD00013C
Homo sapiens	Dihydrofolate reductase	IC50	3.8	nM	10.1021/jm00397a031
Homo sapiens	Dihydrofolate reductase	IC50	3.9	nM	10.1021/jm00105a035
Homo sapiens	Dihydrofolate reductase	IC50	4.0	nM	10.1021/jm00034a015
Homo sapiens	Dihydrofolate reductase	IC50	4.3	nM	10.1021/jm00124a019
Homo sapiens	Dihydrofolate reductase	IC50	4.3	nM	10.1021/jm00127a026
Homo sapiens	Dihydrofolate reductase	IC50	4.6	nM	10.1021/acsmedchemlett.6b00328
Homo sapiens	Dihydrofolate reductase	IC50	4.74	nM	10.1021/acs.jmedchem.8b01754
Homo sapiens	Dihydrofolate reductase	IC50	5.0	nM	10.1016/j.ejmech.2020.112986
Homo sapiens	Dihydrofolate reductase	IC50	6.0	nM	10.1016/j.bmc.2020.115544
Homo sapiens	Dihydrofolate reductase	IC50	6.67	nM	10.1016/j.ejmech.2016.11.010
Homo sapiens	Dihydrofolate reductase	IC50	7.1	nM	10.1016/j.ejmech.2017.12.017
Homo sapiens	Dihydrofolate reductase	IC50	7.9	nM	10.1016/j.ejmech.2016.03.002
Homo sapiens	Dihydrofolate reductase	IC50	7.9	nM	10.1021/acs.jmedchem.6b01253
Homo sapiens	Dihydrofolate reductase	IC50	7.9	nM	10.1021/jm00182a017
Homo sapiens	Dihydrofolate reductase	IC50	9.0	nM	10.1016/j.bmc.2006.11.017
Homo sapiens	Dihydrofolate reductase	IC50	9.0	nM	10.1021/jm040144e
Homo sapiens	Dihydrofolate reductase	IC50	11.2	nM	10.1021/jm00040a008
Homo sapiens	Dihydrofolate reductase	IC50	14.5	nM	10.1021/jm000200l
Homo sapiens	Dihydrofolate reductase	IC50	20.0	nM	10.1016/j.bmc.2012.05.068
Homo sapiens	Dihydrofolate reductase	IC50	20.0	nM	10.1016/j.bmc.2020.115544
Homo sapiens	Dihydrofolate reductase	IC50	20.0	nM	10.1016/j.bmcl.2015.11.083
Homo sapiens	Dihydrofolate reductase	IC50	20.0	nM	10.1021/jm00123a001
Homo sapiens	Dihydrofolate reductase	IC50	20.0	nM	10.1021/jm0701977
Homo sapiens	Dihydrofolate reductase	IC50	20.0	nM	10.1021/jm701052u
Homo sapiens	Dihydrofolate reductase	IC50	20.0	nM	10.1021/jm8006933
Homo sapiens	Dihydrofolate reductase	IC50	20.0	nM	10.1021/jm900490a
Homo sapiens	Dihydrofolate reductase	IC50	22.0	nM	10.1016/j.bmc.2009.11.029
Homo sapiens	Dihydrofolate reductase	IC50	22.0	nM	10.1016/j.bmc.2011.03.067
Homo sapiens	Dihydrofolate reductase	IC50	22.0	nM	10.1016/j.bmcl.2017.02.018
Homo sapiens	Dihydrofolate reductase	IC50	22.0	nM	10.1021/jm000130i
Homo sapiens	Dihydrofolate reductase	IC50	22.0	nM	10.1021/jm010575m
Homo sapiens	Dihydrofolate reductase	IC50	22.0	nM	10.1021/jm0202369
Homo sapiens	Dihydrofolate reductase	IC50	22.0	nM	10.1021/jm0203534
Homo sapiens	Dihydrofolate reductase	IC50	22.0	nM	10.1021/jm040123k
Homo sapiens	Dihydrofolate reductase	IC50	22.0	nM	10.1021/jm058213s
Homo sapiens	Dihydrofolate reductase	IC50	22.0	nM	10.1021/jm058234m
Homo sapiens	Dihydrofolate reductase	IC50	22.0	nM	10.1021/jm058276a
Homo sapiens	Dihydrofolate reductase	IC50	22.0	nM	10.1021/jm070165j
Homo sapiens	Dihydrofolate reductase	IC50	22.0	nM	10.1021/jm800244v
Homo sapiens	Dihydrofolate reductase	IC50	22.0	nM	10.1021/jm9011142
Homo sapiens	Dihydrofolate reductase	IC50	24.0	nM	10.1021/jm00105a036
Homo sapiens	Dihydrofolate reductase	IC50	24.0	nM	10.1021/jm00106a016
Homo sapiens	Dihydrofolate reductase	IC50	24.99	nM	10.1016/j.ejmech.2019.06.013
Homo sapiens	Dihydrofolate reductase	IC50	25.0	nM	10.1021/jm00105a031
Homo sapiens	Dihydrofolate reductase	IC50	26.0	nM	10.1021/jm00177a022
Homo sapiens	Dihydrofolate reductase	IC50	30.0	nM	10.1021/jm00163a035
Homo sapiens	Dihydrofolate reductase	IC50	30.9	nM	10.1016/j.ejmech.2017.01.033
Homo sapiens	Dihydrofolate reductase	IC50	32.94	nM	10.1016/j.ejmech.2008.04.017
Homo sapiens	Dihydrofolate reductase	IC50	35.0	nM	10.1016/j.bmc.2006.11.017
Homo sapiens	Dihydrofolate reductase	IC50	35.0	nM	10.1016/j.bmc.2018.04.035
Homo sapiens	Dihydrofolate reductase	IC50	38.0	nM	10.1021/jm950786p
Homo sapiens	Dihydrofolate reductase	IC50	40.0	nM	10.1021/jm00019a009
Homo sapiens	Dihydrofolate reductase	IC50	61.0	nM	10.1016/j.ejmech.2022.114661
Homo sapiens	Dihydrofolate reductase	IC50	66.0	nM	10.1021/jm0100382
Homo sapiens	Dihydrofolate reductase	IC50	80.0	nM	10.1016/j.bmc.2010.03.019
Homo sapiens	Dihydrofolate reductase	IC50	83.0	nM	10.1021/acsmedchemlett.0c00105
Homo sapiens	Dihydrofolate reductase	IC50	88.0	nM	10.1016/j.bmcl.2023.129285
Homo sapiens	Dihydrofolate reductase	IC50	720.0	nM	10.1021/jm950514m
Homo sapiens	Dihydrofolate reductase	IC50	1000.0	nM	10.1016/j.bmcl.2019.126631
Homo sapiens	Dihydrofolate reductase	IC50	1500.0	nM	10.1016/j.bmcl.2016.03.015
Homo sapiens	Dihydrofolate reductase	IC50/[E]	2.2	nM milliunit-1	10.1021/jm9606453
Homo sapiens	Dihydrofolate reductase	IC80	1.44	uM	10.1021/jm300644g
Homo sapiens	Dihydrofolate reductase	I / E100	1.0	None	10.1021/jm00355a023
Homo sapiens	Dihydrofolate reductase	Inhibition	1.2e-09	%	10.1021/jm00369a024
Homo sapiens	Dihydrofolate reductase	Inhibition	86.0	%	10.1016/j.ejmech.2013.04.017
Homo sapiens	Dihydrofolate reductase	Inhibition	86.4	%	10.1016/j.ejmech.2016.11.010
Homo sapiens	Dihydrofolate reductase	Inhibition	89.7	%	10.1016/j.ejmech.2016.11.010
Homo sapiens	Dihydrofolate reductase	Inhibition	91.0	%	10.1021/acsmedchemlett.0c00105
Homo sapiens	Dihydrofolate reductase	Inhibition	nan	%	10.1016/j.bmc.2020.115544
Homo sapiens	Dihydrofolate reductase	Ki	0.00034	nM	10.1021/jm300563f
Homo sapiens	Dihydrofolate reductase	Ki	0.0012	nM	10.1021/jm00005a002
Homo sapiens	Dihydrofolate reductase	Ki	0.0034	nM	10.1021/acsmedchemlett.6b00120
Homo sapiens	Dihydrofolate reductase	Ki	0.004	nM	10.1021/jm401204g
Homo sapiens	Dihydrofolate reductase	Ki	0.00519	nM	10.1021/jm980477+
Homo sapiens	Dihydrofolate reductase	Ki	0.01	nM	10.1016/j.ejmech.2017.04.070
Homo sapiens	Dihydrofolate reductase	Ki	0.038	nM	10.1016/s0960-894x(99)00213-9
Homo sapiens	Dihydrofolate reductase	Ki	0.077	nM	10.1016/j.bmc.2009.08.044
Homo sapiens	Dihydrofolate reductase	Ki	0.11	nM	10.1021/jm00005a002
Homo sapiens	Dihydrofolate reductase	Ki	0.179	nM	10.1016/s0960-894x(99)00213-9
Homo sapiens	Dihydrofolate reductase	Ki	4420.0	nM	10.1016/j.ejmech.2007.03.035
Homo sapiens	Dihydrofolate reductase	Log Kd	-9.71	None	10.1021/jm0105833
Homo sapiens	Dihydrofolate reductase	Selectivity	88.0	None	10.1021/jm00005a002
Homo sapiens	DJM-1	IC50	20249.98	nM	10.6019/CHEMBL1201861
Homo sapiens	DK-MG	IC50	17392.92	nM	10.6019/CHEMBL1201861
Homo sapiens	DLD-1	GI50	35.65	nM	None
Homo sapiens	DLD-1	IC50	60.0	ug.mL-1	10.1021/jm0701977
Homo sapiens	DMS-114	GI50	28.84	nM	None
Homo sapiens	DMS-114	IC50	9647.04	nM	10.6019/CHEMBL1201861
Homo sapiens	DMS-273	GI50	30.76	nM	None
Homo sapiens	DMS-273	IC50	3705.51	nM	10.6019/CHEMBL1201861
Homo sapiens	DMS-79	IC50	628.13	nM	10.6019/CHEMBL1201861
Homo sapiens	DNA-(apurinic or apyrimidinic site) lyase	Potency	19952.6	nM	None
Homo sapiens	DNA-(apurinic or apyrimidinic site) lyase	Potency	28183.8	nM	None
Homo sapiens	DNA polymerase beta	Potency	39810.7	nM	None
Homo sapiens	DNA polymerase eta	Potency	31622.8	nM	None
Homo sapiens	DNA polymerase iota	Potency	31622.8	nM	None
Homo sapiens	DNA polymerase iota	Potency	100000.0	nM	None
Homo sapiens	DNA polymerase kappa	Potency	14125.4	nM	None
Homo sapiens	DNA polymerase kappa	Potency	79432.8	nM	None
Homo sapiens	DOHH-2	IC50	21.56	nM	10.6019/CHEMBL1201861
Homo sapiens	DOK	IC50	7582.05	nM	10.6019/CHEMBL1201861
Homo sapiens	Dopamine D1 receptor	AC50	10000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Dopamine D1 receptor	IC50	nan	None	None
Homo sapiens	Dopamine D1 receptor	Ki	nan	None	None
Homo sapiens	Dopamine D1 receptor	Potency	4610.9	nM	None
Homo sapiens	Dopamine D2 receptor	AC50	10000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Dopamine D2 receptor	IC50	nan	None	None
Homo sapiens	Dopamine D2 receptor	Ki	nan	None	None
Homo sapiens	Dopamine D3 receptor	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Dopamine D3 receptor	IC50	nan	None	None
Homo sapiens	Dopamine D3 receptor	Ki	nan	None	None
Homo sapiens	Dopamine D4 receptor	IC50	nan	None	None
Homo sapiens	Dopamine D4 receptor	Ki	nan	None	None
Homo sapiens	Dopamine transporter	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Dopamine transporter	IC50	nan	None	None
Homo sapiens	Dopamine transporter	Ki	nan	None	None
Homo sapiens	DoTc2-4510	IC50	7058.21	nM	10.6019/CHEMBL1201861
Homo sapiens	DSH1	IC50	532.72	nM	10.6019/CHEMBL1201861
Homo sapiens	DU-145	GI50	47.64	nM	None
Homo sapiens	DU-145	IC50	23.0	nM	10.1021/jm9606453
Homo sapiens	DU-145	IC50	45.0	nM	10.1021/jm980477+
Homo sapiens	DU-145	IC50	1010.74	nM	10.6019/CHEMBL1201861
Homo sapiens	EC-GI-10	IC50	10625.59	nM	10.6019/CHEMBL1201861
Homo sapiens	EFM-19	IC50	10592.33	nM	10.6019/CHEMBL1201861
Homo sapiens	EFO-21	IC50	3016.66	nM	10.6019/CHEMBL1201861
Homo sapiens	EFO-27	IC50	567.41	nM	10.6019/CHEMBL1201861
Homo sapiens	EGI-1	IC50	19971.26	nM	10.6019/CHEMBL1201861
Homo sapiens	EKVX	GI50	18365.38	nM	None
Homo sapiens	EKVX	IC50	1000.0	nM	10.1021/jm9606453
Homo sapiens	EKVX	IC50	1000.0	nM	10.1021/jm980477+
Homo sapiens	EKVX	IC50	9129.41	nM	10.6019/CHEMBL1201861
Homo sapiens	EM-2	IC50	57.13	nM	10.6019/CHEMBL1201861
Homo sapiens	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Potency	31622.8	nM	None
Homo sapiens	Endothelin receptor ET-A	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Endothelin receptor ET-A	IC50	nan	None	None
Homo sapiens	Endothelin receptor ET-A	Ki	nan	None	None
Homo sapiens	Endothelin receptor ET-B	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Epidermal growth factor receptor erbB1	IC50	nan	None	None
Homo sapiens	Epidermal growth factor receptor erbB1	Ki	nan	None	None
Homo sapiens	EPLC-272H	IC50	5199.57	nM	10.6019/CHEMBL1201861
Homo sapiens	Equilibrative nucleoside transporter 1	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	ES1	IC50	16.39	nM	10.6019/CHEMBL1201861
Homo sapiens	ES3	IC50	242.58	nM	10.6019/CHEMBL1201861
Homo sapiens	ES4	IC50	79.51	nM	10.6019/CHEMBL1201861
Homo sapiens	ES5	IC50	435.31	nM	10.6019/CHEMBL1201861
Homo sapiens	ES6	IC50	428.37	nM	10.6019/CHEMBL1201861
Homo sapiens	ES7	IC50	148.36	nM	10.6019/CHEMBL1201861
Homo sapiens	ES8	IC50	521.99	nM	10.6019/CHEMBL1201861
Homo sapiens	ESS-1	IC50	1026.91	nM	10.6019/CHEMBL1201861
Homo sapiens	Estrogen receptor alpha	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Estrogen receptor alpha	IC50	nan	None	None
Homo sapiens	Estrogen receptor alpha	Ki	nan	None	None
Homo sapiens	Estrogen receptor beta	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Estrogen receptor beta	IC50	nan	None	None
Homo sapiens	Estrogen receptor beta	Ki	nan	None	None
Homo sapiens	ETK-1	IC50	1395.88	nM	10.6019/CHEMBL1201861
Homo sapiens	EW-1	IC50	168.35	nM	10.6019/CHEMBL1201861
Homo sapiens	EW-11	IC50	597.37	nM	10.6019/CHEMBL1201861
Homo sapiens	EW-13	IC50	72.3	nM	10.6019/CHEMBL1201861
Homo sapiens	EW-16	IC50	894.75	nM	10.6019/CHEMBL1201861
Homo sapiens	EW-18	IC50	499.94	nM	10.6019/CHEMBL1201861
Homo sapiens	EW-22	IC50	217.95	nM	10.6019/CHEMBL1201861
Homo sapiens	EW-24	IC50	496.54	nM	10.6019/CHEMBL1201861
Homo sapiens	FaDu	Control	2.0	%	10.1021/jm00019a009
Homo sapiens	FaDu	Control	2.0	%	10.1021/jm00022a015
Homo sapiens	FaDu	Control	2.5	%	10.1021/jm00034a015
Homo sapiens	FaDu	Control	5.75	%	10.1021/jm000130i
Homo sapiens	FaDu	Control	6.0	%	10.1021/jm00019a009
Homo sapiens	FaDu	Control	7.3	%	10.1021/jm00034a015
Homo sapiens	FaDu	Control	8.0	%	10.1021/jm00019a009
Homo sapiens	FaDu	Control	9.25	%	10.1021/jm000130i
Homo sapiens	FaDu	Control	11.0	%	10.1021/jm00022a015
Homo sapiens	FaDu	Control	11.0	%	10.1021/jm00034a015
Homo sapiens	FaDu	Control	11.25	%	10.1021/jm000130i
Homo sapiens	FaDu	Control	18.0	%	10.1021/jm00022a015
Homo sapiens	FaDu	Control	95.0	%	10.1021/jm00022a015
Homo sapiens	FaDu	Control	96.0	%	10.1021/jm00019a009
Homo sapiens	FaDu	Control	98.0	%	10.1021/jm00019a009
Homo sapiens	FaDu	Control	98.0	%	10.1021/jm00034a015
Homo sapiens	FaDu	Control	102.0	%	10.1021/jm000130i
Homo sapiens	FaDu	Control	114.0	%	10.1021/jm00022a015
Homo sapiens	FaDu	Control	114.0	%	10.1021/jm00034a015
Homo sapiens	FaDu	EC50	11.3	nM	10.1021/jm000130i
Homo sapiens	FaDu	EC50	17.0	nM	10.1021/jm00019a009
Homo sapiens	FaDu	EC50	17.0	nM	10.1021/jm00022a015
Homo sapiens	FaDu	EC50	17.0	nM	10.1021/jm0100382
Homo sapiens	FaDu	EC50	19.0	nM	10.1021/jm00034a015
Homo sapiens	FaDu	EC50	31.0	nM	10.1021/jm00012a016
Homo sapiens	FaDu	IC50	6289.16	nM	10.6019/CHEMBL1201861
Homo sapiens	FaDu	Relative growth	1.0	None	10.1021/jm0100382
Homo sapiens	FaDu	Relative growth	4.0	None	10.1021/jm0100382
Homo sapiens	FaDu	Relative growth	4.5	None	10.1021/jm000200l
Homo sapiens	FaDu	Relative growth	11.0	None	10.1021/jm000200l
Homo sapiens	FaDu	Relative growth	31.0	None	10.1021/jm000200l
Homo sapiens	FaDu	Relative growth	100.0	None	10.1021/jm0100382
Homo sapiens	FaDu	Relative growth	101.0	None	10.1021/jm000200l
Homo sapiens	FaDu	Relative growth	110.0	None	10.1021/jm0100382
Homo sapiens	Flap endonuclease 1	Potency	50118.7	nM	None
Homo sapiens	Folate receptor alpha	Activity	nan	None	10.1021/jm9015729
Homo sapiens	Folate receptor alpha	IC50	114.0	nM	10.1021/acs.jmedchem.7b01708
Homo sapiens	Folate receptor alpha	IC50	114.0	nM	10.1021/jm501113m
Homo sapiens	Folate receptor alpha	IC50	216.0	nM	10.1021/acs.jmedchem.7b01708
Homo sapiens	Folate receptor alpha	IC50	461.0	nM	10.1021/jm501113m
Homo sapiens	Folate receptor alpha	Inhibition	nan	%	10.1021/jm401328u
Homo sapiens	Folate receptor alpha	Inhibition	nan	%	10.1021/jm501113m
Homo sapiens	Folate receptor alpha	RBA	0.8	None	10.1021/jm8011323
Homo sapiens	Folate receptor alpha	RBA	nan	None	10.1021/jm201688n
Homo sapiens	Folate receptor beta	Activity	nan	None	10.1021/jm9015729
Homo sapiens	Folate receptor beta	IC50	106.0	nM	10.1021/acs.jmedchem.7b01708
Homo sapiens	Folate receptor beta	IC50	106.0	nM	10.1021/jm501113m
Homo sapiens	Folate receptor beta	IC50	211.0	nM	10.1021/acs.jmedchem.7b01708
Homo sapiens	Folate receptor beta	IC50	211.0	nM	10.1021/jm501113m
Homo sapiens	Folate receptor beta	Inhibition	nan	%	10.1021/jm501113m
Homo sapiens	Folate receptor beta	RBA	0.1	None	10.1021/jm8011323
Homo sapiens	Folate transporter 1	IC50	12.0	nM	10.1021/acs.jmedchem.7b01708
Homo sapiens	Folate transporter 1	IC50	12.0	nM	10.1021/jm501113m
Homo sapiens	Folate transporter 1	Inhibition	60.0	%	10.1021/jm8003366
Homo sapiens	Folate transporter 1	Ki	3500.0	nM	10.1021/jm991119p
Homo sapiens	Folylpoly-gamma-glutamate synthetase	IC50	3200.0	nM	10.1021/jm960250j
Homo sapiens	Folylpoly-gamma-glutamate synthetase	Km	49000.0	nM	10.1021/jm0202369
Homo sapiens	Folylpoly-gamma-glutamate synthetase	Km	49000.0	nM	10.1021/jm0203534
Homo sapiens	Folylpoly-gamma-glutamate synthetase	Km	116000.0	nM	10.1016/0960-894X(96)00053-4
Homo sapiens	Folylpoly-gamma-glutamate synthetase	Km	116000.0	nM	10.1016/s0960-894x(98)00683-0
Homo sapiens	Folylpoly-gamma-glutamate synthetase	Vmax	0.82	uM	10.1021/jm0203534
Homo sapiens	Folylpoly-gamma-glutamate synthetase	Vmax	498.0	nM hr-1 mg-1	10.1016/0960-894X(96)00053-4
Homo sapiens	Folylpoly-gamma-glutamate synthetase	Vmax	498.0	nM hr-1 mg-1	10.1016/s0960-894x(98)00683-0
Homo sapiens	FTC-133	IC50	2513.95	nM	10.6019/CHEMBL1201861
Homo sapiens	G-401	IC50	639.01	nM	10.6019/CHEMBL1201861
Homo sapiens	G-402	IC50	21578.06	nM	10.6019/CHEMBL1201861
Homo sapiens	GAK	IC50	8806.09	nM	10.6019/CHEMBL1201861
Homo sapiens	GAMG	IC50	804.97	nM	10.6019/CHEMBL1201861
Homo sapiens	GAR transformylase	IC50	20000.0	nM	10.1021/jm00396a022
Homo sapiens	Gastric inhibitory polypeptide receptor	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	GB-1	IC50	15399.78	nM	10.6019/CHEMBL1201861
Homo sapiens	GCIY	IC50	12385.3	nM	10.6019/CHEMBL1201861
Homo sapiens	GCT	IC50	16594.23	nM	10.6019/CHEMBL1201861
Homo sapiens	Geminin	Potency	920.0	nM	None
Homo sapiens	Ghrelin receptor	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	GI-1	IC50	19492.41	nM	10.6019/CHEMBL1201861
Homo sapiens	GI-ME-N	IC50	147.16	nM	10.6019/CHEMBL1201861
Homo sapiens	Glucagon receptor	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Glucocorticoid receptor	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Glucocorticoid receptor	IC50	nan	None	None
Homo sapiens	Glucocorticoid receptor	Ki	nan	None	None
Homo sapiens	Glucose transporter	Inhibition	0.58	%	10.6019/CHEMBL3433997
Homo sapiens	Glucose transporter	Inhibition	3.29	%	10.6019/CHEMBL3433997
Homo sapiens	Glucose transporter	Inhibition	4.83	%	10.6019/CHEMBL3433997
Homo sapiens	GMS-10	IC50	21842.66	nM	10.6019/CHEMBL1201861
Homo sapiens	GOTO	IC50	2053.52	nM	10.6019/CHEMBL1201861
Homo sapiens	GP5d	IC50	9614.03	nM	10.6019/CHEMBL1201861
Homo sapiens	GR-ST	IC50	36.28	nM	10.6019/CHEMBL1201861
Homo sapiens	GT3TKB	IC50	10714.66	nM	10.6019/CHEMBL1201861
Homo sapiens	H4	IC50	11475.69	nM	10.6019/CHEMBL1201861
Homo sapiens	H9	ID50	0.03	uM	10.1021/jm00083a017
Homo sapiens	HAL-01	IC50	22.27	nM	10.6019/CHEMBL1201861
Homo sapiens	HBL-100	IC50	40.0	nM	10.1007/s00044-012-0279-4
Homo sapiens	HC-1	IC50	69.57	nM	10.6019/CHEMBL1201861
Homo sapiens	HCC1395	IC50	23230.8	nM	10.6019/CHEMBL1201861
Homo sapiens	HCC1419	IC50	13812.21	nM	10.6019/CHEMBL1201861
Homo sapiens	HCC1569	IC50	6370.95	nM	10.6019/CHEMBL1201861
Homo sapiens	HCC1806	IC50	5254.67	nM	10.6019/CHEMBL1201861
Homo sapiens	HCC1937	IC50	8179.18	nM	10.6019/CHEMBL1201861
Homo sapiens	HCC1954	IC50	11991.1	nM	10.6019/CHEMBL1201861
Homo sapiens	HCC 2998	GI50	119.4	nM	None
Homo sapiens	HCC 2998	IC50	110.0	nM	10.1021/jm980477+
Homo sapiens	HCC 2998	IC50	211.57	nM	10.6019/CHEMBL1201861
Homo sapiens	HCC38	IC50	17567.12	nM	10.6019/CHEMBL1201861
Homo sapiens	HCC70	IC50	389.18	nM	10.6019/CHEMBL1201861
Homo sapiens	HCE-4	IC50	778.72	nM	10.6019/CHEMBL1201861
Homo sapiens	HCE-T	IC50	875.84	nM	10.6019/CHEMBL1201861
Homo sapiens	HCT-116	GI50	10.0	nM	10.1021/jm040785+
Homo sapiens	HCT-116	GI50	15.0	nM	10.1021/acs.jmedchem.6b01253
Homo sapiens	HCT-116	GI50	34.67	nM	None
Homo sapiens	HCT-116	GI50	130.0	nM	10.1016/j.ejmech.2017.07.002
Homo sapiens	HCT-116	GI50	50000.0	nM	10.1021/jm040785+
Homo sapiens	HCT-116	IC50	30.0	nM	10.1021/jm9606453
Homo sapiens	HCT-116	IC50	30.0	nM	10.1021/jm980477+
Homo sapiens	HCT-116	IC50	32.7	nM	10.1021/acs.jnatprod.7b01012
Homo sapiens	HCT-116	IC50	130.0	nM	10.1016/j.bmc.2018.04.035
Homo sapiens	HCT-116	IC50	787.69	nM	10.6019/CHEMBL1201861
Homo sapiens	HCT-116	IC50	9250.0	nM	10.1016/j.ejmech.2022.114661
Homo sapiens	HCT-116	LC50	100000.0	nM	10.1021/acs.jmedchem.6b01253
Homo sapiens	HCT-15	GI50	34.28	nM	None
Homo sapiens	HCT-15	IC50	30.0	nM	10.1021/jm9606453
Homo sapiens	HCT-15	IC50	30.0	nM	10.1021/jm980477+
Homo sapiens	HDLM-2	IC50	10.04	nM	10.6019/CHEMBL1201861
Homo sapiens	HD-MY-Z	IC50	309.51	nM	10.6019/CHEMBL1201861
Homo sapiens	HEC-1	IC50	8075.74	nM	10.6019/CHEMBL1201861
Homo sapiens	HEK293	Activity	65.0	%	10.1021/acs.jmedchem.6b00043
Homo sapiens	HEK293	IC50	22.0	nM	10.1016/j.bmcl.2016.04.096
Homo sapiens	HEK293	IC50	28.6	nM	10.1016/j.bmc.2019.115247
Homo sapiens	HEK293	IC50	35.0	nM	10.1016/j.bmc.2019.115247
Homo sapiens	HEK293	IC50	1270.0	nM	10.1007/s00044-012-0260-2
Homo sapiens	HEK293	Potency	141.3	nM	None
Homo sapiens	HEK293	Potency	231.0	nM	None
Homo sapiens	HEL	IC50	11.45	nM	10.6019/CHEMBL1201861
Homo sapiens	HeLa	GI50	100000.0	nM	10.1016/j.ejmech.2017.07.002
Homo sapiens	HeLa	IC50	21.0	nM	10.1016/j.bmc.2019.115247
Homo sapiens	HeLa	IC50	22.0	nM	10.1016/j.bmcl.2016.04.096
Homo sapiens	HeLa	IC50	59.3	nM	10.1016/j.bmc.2019.115247
Homo sapiens	HeLa	IC50	100.0	nM	10.1016/j.ejmech.2008.04.017
Homo sapiens	HeLa	IC50	820.0	nM	10.1021/acsmedchemlett.0c00105
Homo sapiens	HeLa	IC50	1500.0	nM	10.1021/acsmedchemlett.0c00105
Homo sapiens	HeLa	IC50	13690.0	nM	10.1016/j.ejmech.2022.114661
Homo sapiens	HeLa	IC50	27940.0	nM	10.1016/j.bmc.2020.115540
Homo sapiens	HeLa	IC50	100000.0	nM	10.1016/j.bmc.2018.04.035
Homo sapiens	HeLa	IC50	100000.0	nM	10.1016/j.ejmech.2017.01.033
Homo sapiens	HeLa	IC50	100000.0	nM	10.1016/j.ejmech.2020.112113
Homo sapiens	HeLa	Ratio IC50	1.8	None	10.1021/acsmedchemlett.0c00105
Homo sapiens	H-EMC-SS	IC50	20774.97	nM	10.6019/CHEMBL1201861
Homo sapiens	HEp-2	ED50	0.0024	uM	10.1021/jm00344a018
Homo sapiens	HEp-2	ED50	2.4	nM	10.1021/jm00177a022
Homo sapiens	HepG2	Activity	nan	None	10.1016/j.bmcl.2016.04.096
Homo sapiens	HepG2	GI50	nan	None	10.1016/j.ejmech.2010.11.013
Homo sapiens	HepG2	IC50	22.0	nM	10.1016/j.bmcl.2016.04.096
Homo sapiens	HepG2	IC50	300.0	nM	10.1016/j.ejmech.2019.06.036
Homo sapiens	HepG2	IC50	990.0	nM	10.1016/j.ejmech.2015.01.055
Homo sapiens	HepG2	IC50	21900.0	nM	10.1016/j.ejmech.2022.114661
Homo sapiens	HepG2	IC50 relative	100.0	nM	10.6019/EOS300108
Homo sapiens	HepG2	Inhibition	0.0	%	10.1038/nature09107
Homo sapiens	HepG2	Inhibition	65.0	%	10.1038/nature09107
Homo sapiens	HepG2	LC50	nan	None	10.1016/j.ejmech.2010.11.013
Homo sapiens	HepG2	TGI	nan	None	10.1016/j.ejmech.2010.11.013
Homo sapiens	HERG	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	HERG	IC50	nan	None	None
Homo sapiens	HERG	Ki	nan	None	None
Homo sapiens	HGC-27	IC50	3798.74	nM	10.6019/CHEMBL1201861
Homo sapiens	HH	IC50	31.6	nM	10.6019/CHEMBL1201861
Homo sapiens	High mobility group protein B1	Kd	24.0	nM	10.1021/acs.jmedchem.7b01136
Homo sapiens	High mobility group protein B1	Kd	500.0	nM	10.1021/acs.jmedchem.7b01136
Homo sapiens	Histamine H1 receptor	AC50	10000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Histamine H1 receptor	IC50	nan	None	None
Homo sapiens	Histamine H1 receptor	Ki	nan	None	None
Homo sapiens	Histamine H2 receptor	AC50	10000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Histamine H2 receptor	IC50	nan	None	None
Homo sapiens	Histamine H2 receptor	Ki	nan	None	None
Homo sapiens	Histamine H3 receptor	AC50	10000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Histone acetyltransferase GCN5	Potency	14125.4	nM	None
Homo sapiens	Histone acetyltransferase GCN5	Potency	22387.2	nM	None
Homo sapiens	Histone acetyltransferase GCN5	Potency	31622.8	nM	None
Homo sapiens	Histone acetyltransferase GCN5	Potency	35481.3	nM	None
Homo sapiens	Histone-lysine N-methyltransferase, H3 lysine-9 specific 3	Potency	7519.3	nM	None
Homo sapiens	Histone-lysine N-methyltransferase, H3 lysine-9 specific 3	Potency	7943.3	nM	None
Homo sapiens	Histone-lysine N-methyltransferase, H3 lysine-9 specific 3	Potency	12589.3	nM	None
Homo sapiens	HL-60	Activity	14.0	%	10.1016/j.bmc.2019.115247
Homo sapiens	HL-60	Activity	17.0	%	10.1016/j.bmc.2019.115247
Homo sapiens	HL-60	ED50	0.05	uM	10.1021/jm00401a023
Homo sapiens	HL-60	ED50	0.1	uM	10.1021/jm00401a023
Homo sapiens	HL-60	ED50	609.0	uM	10.1021/jm00401a023
Homo sapiens	HL-60	GI50	38.0	nM	10.1016/j.ejmech.2017.07.002
Homo sapiens	HL-60	GI50	42.95	nM	None
Homo sapiens	HL-60	IC50	6.92	nM	10.1021/np060626o
Homo sapiens	HL-60	IC50	8.1	nM	10.1021/jm00078a004
Homo sapiens	HL-60	IC50	8.9	nM	10.1016/j.bmc.2019.115247
Homo sapiens	HL-60	IC50	9.8	nM	10.1016/j.bmc.2019.115247
Homo sapiens	HL-60	IC50	12.0	nM	10.1016/S0960-894X(96)00486-6
Homo sapiens	HL-60	IC50	12.0	nM	10.1016/S0960-894X(97)00071-1
Homo sapiens	HL-60	IC50	12.0	nM	10.1021/np0003084
Homo sapiens	HL-60	IC50	22.7	nM	10.1016/j.ejmech.2017.01.033
Homo sapiens	HL-60	IC50	23.0	nM	10.1016/j.ejmech.2020.112113
Homo sapiens	HL-60	IC50	24.78	nM	10.6019/CHEMBL1201861
Homo sapiens	HL-60	IC50	25.0	nM	10.1016/j.bmc.2018.04.035
Homo sapiens	HL-60	IC50	39.0	nM	10.1021/jm980477+
Homo sapiens	HL-60	IC50	210.0	nM	10.1016/j.ejmech.2008.04.017
Homo sapiens	HL-60	IC50	nan	None	10.1007/s00044-012-0279-4
Homo sapiens	HL-60	Inhibition	34.2	%	10.1021/jm00401a023
Homo sapiens	HL-60	Inhibition	64.0	%	10.1021/jm00401a023
Homo sapiens	HL-60	Inhibition	87.7	%	10.1021/jm00401a023
Homo sapiens	HLE	IC50	7085.4	nM	10.6019/CHEMBL1201861
Homo sapiens	HMG-CoA reductase	IC50	nan	None	None
Homo sapiens	HMG-CoA reductase	Ki	nan	None	None
Homo sapiens	HMV-2 cell line	IC50	1878.58	nM	10.6019/CHEMBL1201861
Homo sapiens	HN	IC50	6884.48	nM	10.6019/CHEMBL1201861
Homo sapiens	HO-1-N-1	IC50	6174.42	nM	10.6019/CHEMBL1201861
Homo sapiens	Homo sapiens	% absorbed	20.0	%	10.1021/jm001020e
Homo sapiens	Homo sapiens	Activity	0.7	%	10.1016/j.ejmech.2009.11.034
Homo sapiens	Homo sapiens	CL	0.048	mL.min-1.kg-1	10.1124/dmd.112.049312
Homo sapiens	Homo sapiens	CL	0.4	mL.min-1.kg-1	10.1021/jm901371v
Homo sapiens	Homo sapiens	CL	1.108	mL.min-1.kg-1	10.1124/dmd.112.049312
Homo sapiens	Homo sapiens	CL	2.1	mL.min-1.kg-1	10.1021/jm900403j
Homo sapiens	Homo sapiens	CL	2.1	mL.min-1.kg-1	10.1021/jm901371v
Homo sapiens	Homo sapiens	CL_renal	1.7	mL.min-1.kg-1	10.1021/jm900403j
Homo sapiens	Homo sapiens	CL_renal	1.7	mL.min-1.kg-1	10.1021/jm901371v
Homo sapiens	Homo sapiens	DILI_Concern	nan	None	10.1016/j.drudis.2016.02.015
Homo sapiens	Homo sapiens	DILI_severity_class	3.0	None	10.1016/j.drudis.2016.02.015
Homo sapiens	Homo sapiens	EC50	17.2	nM	10.1021/jm9705420
Homo sapiens	Homo sapiens	F	50.0	%	10.1016/j.ejmech.2018.09.027
Homo sapiens	Homo sapiens	F	70.0	%	10.1016/j.bmc.2007.08.060
Homo sapiens	Homo sapiens	Fa	0.7	None	10.1021/jm901371v
Homo sapiens	Homo sapiens	Fabs	20.0	%	10.1124/dmd.110.034629
Homo sapiens	Homo sapiens	F_fraction	0.7	None	10.1021/jm901371v
Homo sapiens	Homo sapiens	Fg	1.02	None	10.1021/jm901371v
Homo sapiens	Homo sapiens	Fh	0.98	None	10.1021/jm901371v
Homo sapiens	Homo sapiens	IC50	13.4	nM	10.1016/j.ejmech.2018.03.076
Homo sapiens	Homo sapiens	IC50	27.5	nM	10.1016/j.ejmech.2018.03.076
Homo sapiens	Homo sapiens	IC50	32.0	nM	10.1021/jm00159a023
Homo sapiens	Homo sapiens	IC50	6600.0	nM	10.1021/jm00159a023
Homo sapiens	Homo sapiens	Kd	0.0048	None	10.1021/jm950793d
Homo sapiens	Homo sapiens	Kd	0.443	None	10.1021/jm950793d
Homo sapiens	Homo sapiens	Kd	10.0	None	10.1021/jm950793d
Homo sapiens	Homo sapiens	Ki	0.0034	None	10.1021/jm950793d
Homo sapiens	Homo sapiens	Ki	0.289	None	10.1021/jm950793d
Homo sapiens	Homo sapiens	Ki	3.5	None	10.1021/jm950793d
Homo sapiens	Homo sapiens	Tmax	1.3	hr	10.1016/j.ejmech.2018.09.027
Homo sapiens	Homo sapiens	Tmax	1.5	hr	10.1016/j.ejmech.2018.09.027
Homo sapiens	Homo sapiens	Vdss	0.43	L.kg-1	10.1021/jm901371v
Homo sapiens	HOP-18	GI50	15885.47	nM	None
Homo sapiens	HOP-62	GI50	40.27	nM	None
Homo sapiens	HOP-92	GI50	7211.07	nM	None
Homo sapiens	HOP-92	IC50	1000.0	nM	10.1021/jm980477+
Homo sapiens	HOP-92	IC50	16653.88	nM	10.6019/CHEMBL1201861
Homo sapiens	HOS	IC50	11007.14	nM	10.6019/CHEMBL1201861
Homo sapiens	HPAF-II	IC50	6118.46	nM	10.6019/CHEMBL1201861
Homo sapiens	Hs-578T	GI50	191866.87	nM	None
Homo sapiens	Hs-578T	IC50	1000.0	nM	10.1021/jm980477+
Homo sapiens	Hs-578T	IC50	24709.73	nM	10.6019/CHEMBL1201861
Homo sapiens	HSC-2	CC50	400000.0	nM	10.1016/j.ejmech.2021.113351
Homo sapiens	HSC-2	IC50	398.7	nM	10.6019/CHEMBL1201861
Homo sapiens	HSC-3	IC50	10283.33	nM	10.6019/CHEMBL1201861
Homo sapiens	HSC-4	IC50	6472.78	nM	10.6019/CHEMBL1201861
Homo sapiens	HT	IC50	133.69	nM	10.6019/CHEMBL1201861
Homo sapiens	HT-1080	IC50	12992.21	nM	10.6019/CHEMBL1201861
Homo sapiens	HT1197	IC50	2612.32	nM	10.6019/CHEMBL1201861
Homo sapiens	HT-1376	IC50	14994.27	nM	10.6019/CHEMBL1201861
Homo sapiens	HT-144	IC50	8206.87	nM	10.6019/CHEMBL1201861
Homo sapiens	HT-29	Activity	nan	None	10.1021/np50063a010
Homo sapiens	HT-29	GI50	33.5	nM	None
Homo sapiens	HT-29	GI50	40.0	nM	10.1016/j.ejmech.2010.11.013
Homo sapiens	HT-29	GI50	40.0	nM	10.1016/j.ejmech.2013.06.001
Homo sapiens	HT-29	GI50	70.0	nM	10.1021/jm040785+
Homo sapiens	HT-29	GI50	50000.0	nM	10.1021/jm040785+
Homo sapiens	HT-29	GI50	100000.0	nM	10.1016/j.ejmech.2017.07.002
Homo sapiens	HT-29	IC50	0.01	ug.mL-1	10.1021/np990140q
Homo sapiens	HT-29	IC50	0.23	ug.mL-1	10.1007/s00044-013-0773-3
Homo sapiens	HT-29	IC50	0.23	ug.mL-1	10.1016/j.ejmech.2010.08.063
Homo sapiens	HT-29	IC50	18.0	nM	10.1021/jm00368a023
Homo sapiens	HT-29	IC50	18.0	nM	10.1021/jm00391a042
Homo sapiens	HT-29	IC50	32.0	nM	10.1021/jm9606453
Homo sapiens	HT-29	IC50	47.82	ug.mL-1	10.1016/j.bmc.2018.12.003
Homo sapiens	HT-29	IC50	153.37	nM	10.6019/CHEMBL1201861
Homo sapiens	HT-29	IC50	1400.0	nM	10.1016/j.ejmech.2012.03.016
Homo sapiens	HT-29	IC50	3450.0	nM	10.1016/j.bmcl.2013.07.059
Homo sapiens	HT-29	IC50	4400.0	nM	10.1021/np50063a010
Homo sapiens	HT-29	IC50	100000.0	nM	10.1016/j.ejmech.2020.112113
Homo sapiens	HT-29	LC50	30.0	nM	10.1016/j.ejmech.2010.11.013
Homo sapiens	HT-29	LC50	100000.0	nM	10.1016/j.ejmech.2013.06.001
Homo sapiens	HT-29	TGI	100000.0	nM	10.1016/j.ejmech.2010.11.013
Homo sapiens	HT-29	TGI	100000.0	nM	10.1016/j.ejmech.2013.06.001
Homo sapiens	HT-3	IC50	69.37	nM	10.6019/CHEMBL1201861
Homo sapiens	HT55	IC50	2408.07	nM	10.6019/CHEMBL1201861
Homo sapiens	HTC-C3	IC50	3442.45	nM	10.6019/CHEMBL1201861
Homo sapiens	HuCCT-1	IC50	16327.49	nM	10.6019/CHEMBL1201861
Homo sapiens	Huh-7	IC50	3188.89	nM	10.6019/CHEMBL1201861
Homo sapiens	HuO-3N1	IC50	89.09	nM	10.6019/CHEMBL1201861
Homo sapiens	HuO9	IC50	1327.94	nM	10.6019/CHEMBL1201861
Homo sapiens	HuP-T3	IC50	4618.39	nM	10.6019/CHEMBL1201861
Homo sapiens	HuP-T4	IC50	8848.49	nM	10.6019/CHEMBL1201861
Homo sapiens	HuTu80	EC50	4.5	nM	10.1021/jm00362a019
Homo sapiens	HuTu80	IC50	9.0	nM	10.1021/jm00391a042
Homo sapiens	HUVEC	Activity	nan	None	10.1016/j.bmc.2009.09.039
Homo sapiens	HUVEC	IC50	6130.0	nM	10.1016/j.ejmech.2019.06.013
Homo sapiens	IA-LM	IC50	13723.04	nM	10.6019/CHEMBL1201861
Homo sapiens	IGR-1	IC50	2738.74	nM	10.6019/CHEMBL1201861
Homo sapiens	IGROV-1	GI50	90.78	nM	None
Homo sapiens	IGROV-1	IC50	21.0	nM	10.1021/jm200739e
Homo sapiens	IGROV-1	IC50	21.0	nM	10.1021/jm8003366
Homo sapiens	IGROV-1	IC50	22.0	nM	10.1021/jm200739e
Homo sapiens	IGROV-1	IC50	22.0	nM	10.1021/jm8003366
Homo sapiens	IGROV-1	IC50	65.0	nM	10.1021/jm980477+
Homo sapiens	Importin subunit beta-1/Snurportin-1	Potency	112201.8	nM	None
Homo sapiens	Interleukin-8 receptor A	IC50	nan	None	None
Homo sapiens	Interleukin-8 receptor A	Ki	nan	None	None
Homo sapiens	Interleukin-8 receptor B	IC50	nan	None	None
Homo sapiens	Interleukin-8 receptor B	Ki	nan	None	None
Homo sapiens	Isocitrate dehydrogenase [NADP] cytoplasmic	Potency	5.2	nM	None
Homo sapiens	IST-MEL1	IC50	126.38	nM	10.6019/CHEMBL1201861
Homo sapiens	IST-MES1	IC50	20665.76	nM	10.6019/CHEMBL1201861
Homo sapiens	IST-SL1	IC50	390.1	nM	10.6019/CHEMBL1201861
Homo sapiens	J82	IC50	4099.42	nM	10.6019/CHEMBL1201861
Homo sapiens	JAR	IC50	188.36	nM	10.6019/CHEMBL1201861
Homo sapiens	JEG-3	IC50	7031.92	nM	10.6019/CHEMBL1201861
Homo sapiens	J-RT3-T3-5	IC50	19.42	nM	10.6019/CHEMBL1201861
Homo sapiens	Jurkat	GI50	1250.0	nM	10.1016/j.bmcl.2011.07.009
Homo sapiens	JVM-2	IC50	2180.64	nM	10.6019/CHEMBL1201861
Homo sapiens	JVM-3	IC50	16.04	nM	10.6019/CHEMBL1201861
Homo sapiens	K5	IC50	59.8	nM	10.6019/CHEMBL1201861
Homo sapiens	K562	GI50	28.51	nM	None
Homo sapiens	K562	GI50	30.0	nM	10.1016/j.ejmech.2010.11.013
Homo sapiens	K562	IC50	26.0	nM	10.1021/jm980477+
Homo sapiens	K562	IC50	4875.06	nM	10.6019/CHEMBL1201861
Homo sapiens	K562	IC50	419000.0	nM	10.1016/j.bmcl.2005.01.083
Homo sapiens	K562	LC50	100000.0	nM	10.1016/j.ejmech.2010.11.013
Homo sapiens	K562	TGI	100000.0	nM	10.1016/j.ejmech.2010.11.013
Homo sapiens	KALS-1	IC50	9083.99	nM	10.6019/CHEMBL1201861
Homo sapiens	Kappa opioid receptor	AC50	10000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Kappa opioid receptor	IC50	nan	None	None
Homo sapiens	Kappa opioid receptor	Ki	nan	None	None
Homo sapiens	KARPAS-299	IC50	493.5	nM	10.6019/CHEMBL1201861
Homo sapiens	KARPAS-45	IC50	123.89	nM	10.6019/CHEMBL1201861
Homo sapiens	KB	Activity	nan	None	10.1021/jm8011323
Homo sapiens	KB	ED50	0.004	ug ml-1	10.1021/jm00193a021
Homo sapiens	KB	IC50	6.0	nM	10.1021/acs.jmedchem.7b01708
Homo sapiens	KB	IC50	6.0	nM	10.1021/jm200739e
Homo sapiens	KB	IC50	6.0	nM	10.1021/jm401139z
Homo sapiens	KB	IC50	6.0	nM	10.1021/jm501113m
Homo sapiens	KB	IC50	6.0	nM	10.1021/jm8003366
Homo sapiens	KB	IC50	8.5	nM	10.1021/jm201688n
Homo sapiens	KB	IC50	10.0	nM	10.1016/j.ejmech.2015.01.055
Homo sapiens	KB	IC50	10.0	nM	10.1016/j.ejmech.2016.03.032
Homo sapiens	KB	IC50	10.0	nM	10.1016/j.ejmech.2019.06.013
Homo sapiens	KB	IC50	19.0	nM	10.1021/jm00037a012
Homo sapiens	KB	IC50	20.0	nM	10.1021/acs.jmedchem.7b01708
Homo sapiens	KB	IC50	20.0	nM	10.1021/jm200739e
Homo sapiens	KB	IC50	20.0	nM	10.1021/jm401139z
Homo sapiens	KB	IC50	20.0	nM	10.1021/jm501113m
Homo sapiens	KB	IC50	20.0	nM	10.1021/jm8003366
Homo sapiens	KB	IC50	20900.0	nM	10.1016/j.ejmech.2012.09.027
Homo sapiens	KB	Inhibition	nan	%	10.1016/j.ejmech.2019.06.013
Homo sapiens	KB	Ratio ED50	1.0	None	10.1021/jm00193a021
Homo sapiens	KE-37	IC50	15.53	nM	10.6019/CHEMBL1201861
Homo sapiens	KG-1	IC50	508.53	nM	10.6019/CHEMBL1201861
Homo sapiens	KGN	IC50	150.12	nM	10.6019/CHEMBL1201861
Homo sapiens	KINGS-1	IC50	614.54	nM	10.6019/CHEMBL1201861
Homo sapiens	KLE	IC50	6159.07	nM	10.6019/CHEMBL1201861
Homo sapiens	KM12	GI50	49.32	nM	None
Homo sapiens	KM12	IC50	33.0	nM	10.1021/jm980477+
Homo sapiens	KM12	IC50	42.0	nM	10.1021/jm9606453
Homo sapiens	KM12	IC50	164.44	nM	10.6019/CHEMBL1201861
Homo sapiens	KM-20L2	GI50	43.95	nM	None
Homo sapiens	KM-H2	IC50	369.4	nM	10.6019/CHEMBL1201861
Homo sapiens	KMOE-2	IC50	97.42	nM	10.6019/CHEMBL1201861
Homo sapiens	KNS-42	IC50	22979.1	nM	10.6019/CHEMBL1201861
Homo sapiens	KNS-62	IC50	5912.16	nM	10.6019/CHEMBL1201861
Homo sapiens	KNS-81-FD	IC50	9632.43	nM	10.6019/CHEMBL1201861
Homo sapiens	KOSC-2	IC50	2342.93	nM	10.6019/CHEMBL1201861
Homo sapiens	KP-4	IC50	3154.03	nM	10.6019/CHEMBL1201861
Homo sapiens	KP-N-YN	IC50	18849.42	nM	10.6019/CHEMBL1201861
Homo sapiens	KP-N-YS	IC50	3396.1	nM	10.6019/CHEMBL1201861
Homo sapiens	KS-1	IC50	10768.71	nM	10.6019/CHEMBL1201861
Homo sapiens	KU-19-19	IC50	1077.52	nM	10.6019/CHEMBL1201861
Homo sapiens	KURAMOCHI	IC50	1886.94	nM	10.6019/CHEMBL1201861
Homo sapiens	KYSE-140	IC50	1245.29	nM	10.6019/CHEMBL1201861
Homo sapiens	KYSE-150 cell line	IC50	115.06	nM	10.6019/CHEMBL1201861
Homo sapiens	KYSE-180	IC50	1212.05	nM	10.6019/CHEMBL1201861
Homo sapiens	KYSE-270	IC50	52.11	nM	10.6019/CHEMBL1201861
Homo sapiens	KYSE-410	IC50	3639.26	nM	10.6019/CHEMBL1201861
Homo sapiens	KYSE-450	IC50	334.47	nM	10.6019/CHEMBL1201861
Homo sapiens	KYSE-510	IC50	91.72	nM	10.6019/CHEMBL1201861
Homo sapiens	KYSE-520 cell line	IC50	4454.56	nM	10.6019/CHEMBL1201861
Homo sapiens	KYSE-70 cell line	IC50	6165.83	nM	10.6019/CHEMBL1201861
Homo sapiens	L-363	IC50	14.26	nM	10.6019/CHEMBL1201861
Homo sapiens	L-428	IC50	1256.7	nM	10.6019/CHEMBL1201861
Homo sapiens	LAMA-84	IC50	12.39	nM	10.6019/CHEMBL1201861
Homo sapiens	LAN-6	IC50	1745.62	nM	10.6019/CHEMBL1201861
Homo sapiens	LB1047-RCC	IC50	15223.85	nM	10.6019/CHEMBL1201861
Homo sapiens	LB2241-RCC	IC50	13798.38	nM	10.6019/CHEMBL1201861
Homo sapiens	LB2518-MEL	IC50	6822.67	nM	10.6019/CHEMBL1201861
Homo sapiens	LB771-HNC	IC50	17719.93	nM	10.6019/CHEMBL1201861
Homo sapiens	LB831-BLC	IC50	1711.51	nM	10.6019/CHEMBL1201861
Homo sapiens	LC-2-ad	IC50	2162.7	nM	10.6019/CHEMBL1201861
Homo sapiens	LCLC-103H cell line	IC50	173.89	nM	10.6019/CHEMBL1201861
Homo sapiens	LCLC-97TM1	IC50	422.2	nM	10.6019/CHEMBL1201861
Homo sapiens	Leukocyte common antigen	IC50	nan	None	None
Homo sapiens	Leukocyte common antigen	Ki	nan	None	None
Homo sapiens	Leukocyte elastase	IC50	nan	None	None
Homo sapiens	Leukocyte elastase	Ki	nan	None	None
Homo sapiens	Liver microsomes	Activity	nan	None	10.1021/tx300075j
Homo sapiens	Liver microsomes	Stability	nan	%	10.1021/tx300075j
Homo sapiens	LK-2	IC50	317.51	nM	10.6019/CHEMBL1201861
Homo sapiens	LN-405	IC50	3363.25	nM	10.6019/CHEMBL1201861
Homo sapiens	LNCaP	IC50	300.0	nM	10.1016/j.ejmech.2012.03.016
Homo sapiens	LNCaP-Clone-FGC	IC50	9577.98	nM	10.6019/CHEMBL1201861
Homo sapiens	LoVo	IC50	13744.35	nM	10.6019/CHEMBL1201861
Homo sapiens	LOX IMVI	GI50	27.42	nM	None
Homo sapiens	LOX IMVI	IC50	0.057	ug.mL-1	10.1021/jm0701977
Homo sapiens	LOX IMVI	IC50	26.0	nM	10.1021/jm9606453
Homo sapiens	LOX IMVI	IC50	26.0	nM	10.1021/jm980477+
Homo sapiens	LOX IMVI	IC50	201.86	nM	10.6019/CHEMBL1201861
Homo sapiens	LS-1034	IC50	6867.75	nM	10.6019/CHEMBL1201861
Homo sapiens	LS-123	IC50	10289.17	nM	10.6019/CHEMBL1201861
Homo sapiens	LS-411N	IC50	117.59	nM	10.6019/CHEMBL1201861
Homo sapiens	LS-513	IC50	4353.08	nM	10.6019/CHEMBL1201861
Homo sapiens	LU-134-A	IC50	88.65	nM	10.6019/CHEMBL1201861
Homo sapiens	LU-135	IC50	2230.07	nM	10.6019/CHEMBL1201861
Homo sapiens	LU-139	IC50	235.41	nM	10.6019/CHEMBL1201861
Homo sapiens	Lu-65	IC50	4077.99	nM	10.6019/CHEMBL1201861
Homo sapiens	LU-99A	IC50	273.84	nM	10.6019/CHEMBL1201861
Homo sapiens	LXF-289 cell line	IC50	6562.65	nM	10.6019/CHEMBL1201861
Homo sapiens	LXFL 529	GI50	33.65	nM	None
Homo sapiens	Lysine-specific demethylase 4D-like	Potency	28183.8	nM	None
Homo sapiens	Lysine-specific demethylase 4D-like	Potency	31622.8	nM	None
Homo sapiens	M059J	IC50	15123.94	nM	10.6019/CHEMBL1201861
Homo sapiens	M14	GI50	33.42	nM	None
Homo sapiens	M14	IC50	32.0	nM	10.1021/jm980477+
Homo sapiens	M14	IC50	1942.98	nM	10.6019/CHEMBL1201861
Homo sapiens	M19-MEL	GI50	423.64	nM	None
Homo sapiens	M21	IC50	108.0	ug.mL-1	10.1021/jm00131a003
Homo sapiens	M21	IC50	109.0	ug.mL-1	10.1021/jm00131a003
Homo sapiens	M21	IC50	112.0	ug.mL-1	10.1021/jm00131a003
Homo sapiens	M21	IC50	115.0	ug.mL-1	10.1021/jm00131a003
Homo sapiens	M21	IC50	117.0	ug.mL-1	10.1021/jm00131a003
Homo sapiens	M21	IC50	118.0	ug.mL-1	10.1021/jm00131a003
Homo sapiens	M21	IC50	119.0	ug.mL-1	10.1021/jm00131a003
Homo sapiens	M21	IC50	120.0	ug.mL-1	10.1021/jm00131a003
Homo sapiens	M21	IC50	121.0	ug.mL-1	10.1021/jm00131a003
Homo sapiens	Malme-3M	GI50	2355.05	nM	None
Homo sapiens	Malme-3M	IC50	1000.0	nM	10.1021/jm9606453
Homo sapiens	Malme-3M	IC50	1000.0	nM	10.1021/jm980477+
Homo sapiens	MAP kinase ERK1	IC50	nan	None	None
Homo sapiens	MAP kinase ERK1	Ki	nan	None	None
Homo sapiens	MAP kinase ERK2	IC50	nan	None	None
Homo sapiens	MAP kinase ERK2	Ki	nan	None	None
Homo sapiens	MAP kinase p38 alpha	IC50	nan	None	None
Homo sapiens	MAP kinase p38 alpha	Ki	nan	None	None
Homo sapiens	Matrix metalloproteinase-1	IC50	nan	None	None
Homo sapiens	Matrix metalloproteinase-1	Ki	nan	None	None
Homo sapiens	Matrix metalloproteinase 9	IC50	nan	None	None
Homo sapiens	Matrix metalloproteinase 9	Ki	nan	None	None
Homo sapiens	MC116	IC50	60.61	nM	10.6019/CHEMBL1201861
Homo sapiens	MCF7	Activity	0.1	pM (10e6*cells)-1	10.1021/jm00089a009
Homo sapiens	MCF7	Activity	0.3	pM (10e6*cells)-1	10.1021/jm00089a009
Homo sapiens	MCF7	Activity	0.4	pM (10e6*cells)-1	10.1021/jm00089a009
Homo sapiens	MCF7	Activity	0.6	pM (10e6*cells)-1	10.1021/jm00089a009
Homo sapiens	MCF7	Activity	0.8	pM (10e6*cells)-1	10.1021/jm00089a009
Homo sapiens	MCF7	Activity	1.6	pM (10e6*cells)-1	10.1021/jm00089a009
Homo sapiens	MCF7	Activity	4.1	pM (10e6*cells)-1	10.1021/jm00089a009
Homo sapiens	MCF7	Activity	50.0	%	10.1039/d0md00051e
Homo sapiens	MCF7	Activity	nan	None	10.1021/acs.jmedchem.7b01775
Homo sapiens	MCF7	EC50	900.0	nM	10.1016/j.bmcl.2010.07.024
Homo sapiens	MCF7	GI50	24.0	nM	10.1016/j.ejmech.2016.03.002
Homo sapiens	MCF7	GI50	24.0	nM	10.1021/acs.jmedchem.6b01253
Homo sapiens	MCF7	GI50	48.64	nM	None
Homo sapiens	MCF7	GI50	60.0	nM	10.1016/j.ejmech.2010.11.013
Homo sapiens	MCF7	GI50	60.0	nM	10.1016/j.ejmech.2013.06.001
Homo sapiens	MCF7	IC50	15.0	nM	10.1039/d0md00051e
Homo sapiens	MCF7	IC50	31.48	ug.mL-1	10.1016/j.bmc.2018.12.003
Homo sapiens	MCF7	IC50	36.0	nM	10.1021/jm9606453
Homo sapiens	MCF7	IC50	36.0	nM	10.1021/jm980477+
Homo sapiens	MCF7	IC50	50.0	nM	10.1021/jm801522j
Homo sapiens	MCF7	IC50	97.0	nM	10.1016/j.ejmech.2017.08.032
Homo sapiens	MCF7	IC50	800.0	nM	10.1016/j.ejmech.2016.03.034
Homo sapiens	MCF7	IC50	2260.0	nM	10.1007/s00044-012-0260-2
Homo sapiens	MCF7	IC50	16198.91	nM	10.6019/CHEMBL1201861
Homo sapiens	MCF7	IC50	22000.0	nM	10.1039/d0md00051e
Homo sapiens	MCF7	IC50	25320.0	nM	10.1016/j.ejmech.2022.114661
Homo sapiens	MCF7	IC50	27090.0	nM	10.1016/j.ejmech.2019.111587
Homo sapiens	MCF7	IC50	49220.0	nM	10.1016/j.bmc.2020.115540
Homo sapiens	MCF7	IC50	nan	None	10.1016/j.ejmech.2012.03.016
Homo sapiens	MCF7	IC50	nan	None	10.1021/np500836y
Homo sapiens	MCF7	Inhibition	82.8	%	10.1016/j.ejmech.2019.111965
Homo sapiens	MCF7	LC50	40.0	nM	10.1016/j.ejmech.2010.11.013
Homo sapiens	MCF7	LC50	100000.0	nM	10.1016/j.ejmech.2013.06.001
Homo sapiens	MCF7	LC50	100000.0	nM	10.1016/j.ejmech.2016.03.002
Homo sapiens	MCF7	LC50	100000.0	nM	10.1021/acs.jmedchem.6b01253
Homo sapiens	MCF7	TGI	55.0	%	10.1039/d0md00051e
Homo sapiens	MCF7	TGI	79.92	%	10.1039/d0md00051e
Homo sapiens	MCF7	TGI	100000.0	nM	10.1016/j.ejmech.2010.11.013
Homo sapiens	MCF7	TGI	100000.0	nM	10.1016/j.ejmech.2013.06.001
Homo sapiens	MC-IXC	IC50	9512.89	nM	10.6019/CHEMBL1201861
Homo sapiens	MDA-MB-157	IC50	3245.93	nM	10.6019/CHEMBL1201861
Homo sapiens	MDA-MB-175-VII	IC50	17429.65	nM	10.6019/CHEMBL1201861
Homo sapiens	MDA-MB-231	Activity	nan	None	10.1021/acs.jmedchem.6b00043
Homo sapiens	MDA-MB-231	Drug metabolism	32.0	%	10.1021/acs.jmedchem.7b00762
Homo sapiens	MDA-MB-231	EC50	80000.0	nM	10.1016/j.bmcl.2010.07.024
Homo sapiens	MDA-MB-231	GI50	38725.76	nM	None
Homo sapiens	MDA-MB-231	IC50	500.0	nM	10.1021/acs.jmedchem.6b00043
Homo sapiens	MDA-MB-231	IC50	501.19	nM	10.1021/acs.jmedchem.6b00043
Homo sapiens	MDA-MB-231	IC50	22897.96	nM	10.6019/CHEMBL1201861
Homo sapiens	MDA-MB-231	IC50	100000.0	nM	10.1016/j.ejmech.2016.03.034
Homo sapiens	MDA-MB-231	Inhibition	40.1	%	10.1016/j.ejmech.2019.111965
Homo sapiens	MDA-MB-231	Survival	35.0	%	10.1039/d0md00051e
Homo sapiens	MDA-MB-231	Survival	60.0	%	10.1039/d0md00051e
Homo sapiens	MDA-MB-361	IC50	12293.79	nM	10.6019/CHEMBL1201861
Homo sapiens	MDA-MB-415	IC50	8424.65	nM	10.6019/CHEMBL1201861
Homo sapiens	MDA-MB-435	GI50	34.12	nM	None
Homo sapiens	MDA-MB-435	IC50	1000.0	nM	10.1021/jm980477+
Homo sapiens	MDA-MB-453	IC50	5897.94	nM	10.6019/CHEMBL1201861
Homo sapiens	MDA-MB-468	Activity	nan	None	10.1021/acs.jmedchem.6b00043
Homo sapiens	MDA-MB-468	IC50	199.53	nM	10.1021/acs.jmedchem.6b00043
Homo sapiens	MDA-MB-468	IC50	200.0	nM	10.1021/acs.jmedchem.6b00043
Homo sapiens	MDA-N	GI50	44.87	nM	None
Homo sapiens	ME-180	IC50	587.74	nM	10.6019/CHEMBL1201861
Homo sapiens	MEG-01	IC50	99.44	nM	10.6019/CHEMBL1201861
Homo sapiens	Melanocortin receptor 3	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Melanocortin receptor 3	IC50	nan	None	None
Homo sapiens	Melanocortin receptor 3	Ki	nan	None	None
Homo sapiens	Melanocortin receptor 4	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Melanocortin receptor 4	IC50	nan	None	None
Homo sapiens	Melanocortin receptor 4	Ki	nan	None	None
Homo sapiens	Melanocortin receptor 5	IC50	nan	None	None
Homo sapiens	Melanocortin receptor 5	Ki	nan	None	None
Homo sapiens	MEL-HO	IC50	2928.93	nM	10.6019/CHEMBL1201861
Homo sapiens	MEL-JUSO	IC50	4744.18	nM	10.6019/CHEMBL1201861
Homo sapiens	Menin/Histone-lysine N-methyltransferase MLL	Potency	39810.7	nM	None
Homo sapiens	Methionine synthase	IC50	0.0	nM	10.1016/j.ejmech.2020.112113
Homo sapiens	MeWo	IC50	3735.22	nM	10.6019/CHEMBL1201861
Homo sapiens	MFE-280	IC50	13761.05	nM	10.6019/CHEMBL1201861
Homo sapiens	MFM-223	IC50	6060.13	nM	10.6019/CHEMBL1201861
Homo sapiens	MG-63	IC50	197.1	nM	10.6019/CHEMBL1201861
Homo sapiens	MHH-ES-1	IC50	107.01	nM	10.6019/CHEMBL1201861
Homo sapiens	MHH-NB-11	IC50	409.51	nM	10.6019/CHEMBL1201861
Homo sapiens	MHH-PREB-1	IC50	13.23	nM	10.6019/CHEMBL1201861
Homo sapiens	MIA PaCa-2	IC50	9125.28	nM	10.6019/CHEMBL1201861
Homo sapiens	Microtubule-associated protein tau	Potency	10000.0	nM	None
Homo sapiens	Microtubule-associated protein tau	Potency	17782.8	nM	None
Homo sapiens	Microtubule-associated protein tau	Potency	19952.6	nM	None
Homo sapiens	Microtubule-associated protein tau	Potency	39810.7	nM	None
Homo sapiens	MKN-1	IC50	2246.41	nM	10.6019/CHEMBL1201861
Homo sapiens	MKN-28	IC50	1333.91	nM	10.6019/CHEMBL1201861
Homo sapiens	MKN-45	IC50	872.29	nM	10.6019/CHEMBL1201861
Homo sapiens	MKN-7	IC50	12063.92	nM	10.6019/CHEMBL1201861
Homo sapiens	ML-2	IC50	4.967	nM	10.6019/CHEMBL1201861
Homo sapiens	MLMA	IC50	96.54	nM	10.6019/CHEMBL1201861
Homo sapiens	MMAC-SF	IC50	19553.18	nM	10.6019/CHEMBL1201861
Homo sapiens	MN-60	IC50	65.73	nM	10.6019/CHEMBL1201861
Homo sapiens	Mo	IC50	5491.03	nM	10.6019/CHEMBL1201861
Homo sapiens	MOLT-16	IC50	11.6	nM	10.6019/CHEMBL1201861
Homo sapiens	MOLT-4	GI50	32.58	nM	None
Homo sapiens	MOLT-4	IC50	21.17	nM	10.6019/CHEMBL1201861
Homo sapiens	MOLT-4	IC50	28.0	nM	10.1021/jm980477+
Homo sapiens	MOLT-4	IC50	48.0	nM	10.1016/S0960-894X(96)00486-6
Homo sapiens	MOLT-4	IC50	1400.0	nM	10.1021/jm00113a011
Homo sapiens	Monoamine oxidase A	AC50	10000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Monoamine oxidase A	IC50	nan	None	None
Homo sapiens	Monoamine oxidase A	Ki	nan	None	None
Homo sapiens	Monoamine oxidase B	Activity	nan	None	10.1021/jm800656v
Homo sapiens	MONO-MAC-6	Activity	140.0	%	10.1016/j.ejmech.2012.03.016
Homo sapiens	MONO-MAC-6	Activity	nan	None	10.1016/j.ejmech.2012.03.016
Homo sapiens	MONO-MAC-6	Inhibition	27.0	%	10.1016/j.ejmech.2012.03.016
Homo sapiens	MONO-MAC-6	Inhibition	29.0	%	10.1016/j.ejmech.2012.03.016
Homo sapiens	MONO-MAC-6	Inhibition	52.0	%	10.1016/j.ejmech.2012.03.016
Homo sapiens	MONO-MAC-6	Inhibition	60.0	%	10.1016/j.ejmech.2012.03.016
Homo sapiens	MONO-MAC-6	Inhibition	80.0	%	10.1016/j.ejmech.2012.03.016
Homo sapiens	MONO-MAC-6	Inhibition	89.0	%	10.1016/j.ejmech.2012.03.016
Homo sapiens	MONO-MAC-6	Inhibition	94.0	%	10.1016/j.ejmech.2012.03.016
Homo sapiens	MONO-MAC-6	Inhibition	96.0	%	10.1016/j.ejmech.2012.03.016
Homo sapiens	MONO-MAC-6	Inhibition	97.0	%	10.1016/j.ejmech.2012.03.016
Homo sapiens	MONO-MAC-6	Inhibition	101.0	%	10.1016/j.ejmech.2012.03.016
Homo sapiens	MONO-MAC-6	Inhibition	102.0	%	10.1016/j.ejmech.2012.03.016
Homo sapiens	MONO-MAC-6	Ratio	0.76	None	10.1016/j.ejmech.2012.03.016
Homo sapiens	MONO-MAC-6	Ratio	0.77	None	10.1016/j.ejmech.2012.03.016
Homo sapiens	MONO-MAC-6	Ratio	0.95	None	10.1016/j.ejmech.2012.03.016
Homo sapiens	MONO-MAC-6	Ratio	0.98	None	10.1016/j.ejmech.2012.03.016
Homo sapiens	Motilin receptor	AC50	10000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	M-phase phosphoprotein 8	Potency	79432.8	nM	None
Homo sapiens	MPP-89	IC50	11256.58	nM	10.6019/CHEMBL1201861
Homo sapiens	MS-1	IC50	45.26	nM	10.6019/CHEMBL1201861
Homo sapiens	MSTO-211H	IC50	518.65	nM	10.6019/CHEMBL1201861
Homo sapiens	Multidrug resistance associated protein	Activity	10.0	%	10.1152/ajpgi.00331.2002
Homo sapiens	Multidrug resistance associated protein	Activity	nan	None	10.1152/ajpgi.00331.2002
Homo sapiens	Multidrug resistance associated protein	Ki	1200000.0	nM	10.1023/a:1013699130991
Homo sapiens	Multidrug resistance associated protein	Km	620000.0	nM	None
Homo sapiens	Multidrug resistance associated protein	Km	776000.0	nM	None
Homo sapiens	Multidrug resistance associated protein	Km	910000.0	nM	10.1021/bi027347u
Homo sapiens	Multidrug resistance-associated protein 1	Activity	82.0	%	10.1016/s0005-2736(97)00003-5
Homo sapiens	Multidrug resistance-associated protein 1	Km	930000.0	nM	10.1021/bi027347u
Homo sapiens	Multidrug resistance-associated protein 1	Km	2150000.0	nM	None
Homo sapiens	Multidrug resistance-associated protein 4	Activity	39.0	%	10.1053/jhep.2003.50331
Homo sapiens	Multidrug resistance-associated protein 4	Activity	40.3	%	10.1074/jbc.m104833200
Homo sapiens	Multidrug resistance-associated protein 4	Activity	53.0	%	10.1016/s1357-2725(03)00236-x
Homo sapiens	Multidrug resistance-associated protein 4	Activity	nan	None	10.1038/nrd3028
Homo sapiens	Multidrug resistance-associated protein 4	IC50	133000.0	nM	10.1093/toxsci/kft176
Homo sapiens	Multidrug resistance-associated protein 4	Km	1300000.0	nM	10.1681/asn.v133595
Homo sapiens	Multidrug resistance-associated protein 7	Activity	74.0	%	10.1124/mol.63.2.351
Homo sapiens	Mu opioid receptor	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Mu opioid receptor	IC50	nan	None	None
Homo sapiens	Mu opioid receptor	Ki	nan	None	None
Homo sapiens	Muscarinic acetylcholine receptor M1	AC50	10000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Muscarinic acetylcholine receptor M1	IC50	nan	None	None
Homo sapiens	Muscarinic acetylcholine receptor M1	Ki	nan	None	None
Homo sapiens	Muscarinic acetylcholine receptor M2	AC50	10000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Muscarinic acetylcholine receptor M2	IC50	nan	None	None
Homo sapiens	Muscarinic acetylcholine receptor M2	Ki	nan	None	None
Homo sapiens	Muscarinic acetylcholine receptor M3	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Muscarinic acetylcholine receptor M3	IC50	nan	None	None
Homo sapiens	Muscarinic acetylcholine receptor M3	Ki	nan	None	None
Homo sapiens	Muscarinic acetylcholine receptor M4	IC50	nan	None	None
Homo sapiens	Muscarinic acetylcholine receptor M4	Ki	nan	None	None
Homo sapiens	Muscarinic acetylcholine receptor M5	IC50	nan	None	None
Homo sapiens	Muscarinic acetylcholine receptor M5	Ki	nan	None	None
Homo sapiens	Muscleblind-like protein 1	Potency	11220.2	nM	None
Homo sapiens	MV4-11	IC50	19.35	nM	10.6019/CHEMBL1201861
Homo sapiens	MZ1-PC	IC50	8833.46	nM	10.6019/CHEMBL1201861
Homo sapiens	MZ2-MEL	IC50	9826.77	nM	10.6019/CHEMBL1201861
Homo sapiens	MZ7-mel	IC50	11182.9	nM	10.6019/CHEMBL1201861
Homo sapiens	NB10	IC50	5512.18	nM	10.6019/CHEMBL1201861
Homo sapiens	NB12	IC50	19653.12	nM	10.6019/CHEMBL1201861
Homo sapiens	NB13	IC50	5260.73	nM	10.6019/CHEMBL1201861
Homo sapiens	NB14	IC50	75.01	nM	10.6019/CHEMBL1201861
Homo sapiens	NB17	IC50	16832.29	nM	10.6019/CHEMBL1201861
Homo sapiens	NB5	IC50	14227.49	nM	10.6019/CHEMBL1201861
Homo sapiens	NB6	IC50	25876.73	nM	10.6019/CHEMBL1201861
Homo sapiens	NB69	IC50	14732.09	nM	10.6019/CHEMBL1201861
Homo sapiens	NB7	IC50	447.6	nM	10.6019/CHEMBL1201861
Homo sapiens	NBsusSR	IC50	29.58	nM	10.6019/CHEMBL1201861
Homo sapiens	NCI/ADR-RES	GI50	92.9	nM	None
Homo sapiens	NCI/ADR-RES	IC50	78.0	nM	10.1021/jm9606453
Homo sapiens	NCI/ADR-RES	IC50	78.0	nM	10.1021/jm980477+
Homo sapiens	NCI-H1048	IC50	328.42	nM	10.6019/CHEMBL1201861
Homo sapiens	NCI-H1092	IC50	922.04	nM	10.6019/CHEMBL1201861
Homo sapiens	NCI-H1155	IC50	266.18	nM	10.6019/CHEMBL1201861
Homo sapiens	NCI-H1299	GI50	72.0	nM	10.1016/j.ejmech.2017.07.002
Homo sapiens	NCI-H1299	IC50	72.0	nM	10.1016/j.ejmech.2017.01.033
Homo sapiens	NCI-H1299	IC50	72.0	nM	10.1016/j.ejmech.2020.112113
Homo sapiens	NCI-H1299	IC50	250.03	nM	10.6019/CHEMBL1201861
Homo sapiens	NCI-H1304	IC50	2408.94	nM	10.6019/CHEMBL1201861
Homo sapiens	NCI-H1355	IC50	10878.01	nM	10.6019/CHEMBL1201861
Homo sapiens	NCI-H1395	IC50	7279.89	nM	10.6019/CHEMBL1201861
Homo sapiens	NCI-H1437	IC50	1677.36	nM	10.6019/CHEMBL1201861
Homo sapiens	NCI-H1563	IC50	1433.68	nM	10.6019/CHEMBL1201861
Homo sapiens	NCI-H1573	IC50	13217.74	nM	10.6019/CHEMBL1201861
Homo sapiens	NCI-H1581	IC50	8690.38	nM	10.6019/CHEMBL1201861
Homo sapiens	NCI-H1623	IC50	13117.5	nM	10.6019/CHEMBL1201861
Homo sapiens	NCI-H1648	IC50	14804.07	nM	10.6019/CHEMBL1201861
Homo sapiens	NCI-H1650	IC50	1628.66	nM	10.6019/CHEMBL1201861
Homo sapiens	NCI-H1651	IC50	7802.43	nM	10.6019/CHEMBL1201861
Homo sapiens	NCI-H1666	IC50	448.79	nM	10.6019/CHEMBL1201861
Homo sapiens	NCI-H1693	IC50	6680.28	nM	10.6019/CHEMBL1201861
Homo sapiens	NCI-H1703	IC50	20308.77	nM	10.6019/CHEMBL1201861
Homo sapiens	NCI-H1755	IC50	287.21	nM	10.6019/CHEMBL1201861
Homo sapiens	NCI-H1770	IC50	1.983	nM	10.6019/CHEMBL1201861
Homo sapiens	NCI-H1792	IC50	114.24	nM	10.6019/CHEMBL1201861
Homo sapiens	NCI-H1793	IC50	2340.4	nM	10.6019/CHEMBL1201861
Homo sapiens	NCI-H1838	IC50	2711.46	nM	10.6019/CHEMBL1201861
Homo sapiens	NCI-H1993	IC50	23188.35	nM	10.6019/CHEMBL1201861
Homo sapiens	NCI-H2029	IC50	25796.66	nM	10.6019/CHEMBL1201861
Homo sapiens	NCI-H2030	IC50	9183.52	nM	10.6019/CHEMBL1201861
Homo sapiens	NCI-H2052	IC50	2509.68	nM	10.6019/CHEMBL1201861
Homo sapiens	NCI-H2087	IC50	10166.71	nM	10.6019/CHEMBL1201861
Homo sapiens	NCI-H209	IC50	365.82	nM	10.6019/CHEMBL1201861
Homo sapiens	NCI-H2122	IC50	151.43	nM	10.6019/CHEMBL1201861
Homo sapiens	NCI-H2126	IC50	13715.83	nM	10.6019/CHEMBL1201861
Homo sapiens	NCI-H2170	IC50	7859.67	nM	10.6019/CHEMBL1201861
Homo sapiens	NCI-H2228	IC50	7687.12	nM	10.6019/CHEMBL1201861
Homo sapiens	NCI-H226	GI50	10250.0	nM	10.1016/j.bmcl.2011.07.009
Homo sapiens	NCI-H226	GI50	20044.72	nM	None
Homo sapiens	NCI-H226	IC50	1000.0	nM	10.1021/jm980477+
Homo sapiens	NCI-H226	IC50	5355.17	nM	10.6019/CHEMBL1201861
Homo sapiens	NCI-H2291	IC50	4340.85	nM	10.6019/CHEMBL1201861
Homo sapiens	NCI-H23	GI50	40.83	nM	None
Homo sapiens	NCI-H23	IC50	0.29	ug.mL-1	10.1021/jm0701977
Homo sapiens	NCI-H23	IC50	43.0	nM	10.1021/jm9606453
Homo sapiens	NCI-H23	IC50	43.0	nM	10.1021/jm980477+
Homo sapiens	NCI-H23	IC50	293.21	nM	10.6019/CHEMBL1201861
Homo sapiens	NCI-H2342	IC50	21618.45	nM	10.6019/CHEMBL1201861
Homo sapiens	NCI-H2347	IC50	9716.96	nM	10.6019/CHEMBL1201861
Homo sapiens	NCI-H2405	IC50	29089.52	nM	10.6019/CHEMBL1201861
Homo sapiens	NCI-H2452	IC50	650.63	nM	10.6019/CHEMBL1201861
Homo sapiens	NCI-H28	IC50	299.05	nM	10.6019/CHEMBL1201861
Homo sapiens	NCI-H292	IC50	6477.48	nM	10.6019/CHEMBL1201861
Homo sapiens	NCI-H322M	GI50	603.95	nM	None
Homo sapiens	NCI-H358	IC50	250.58	nM	10.6019/CHEMBL1201861
Homo sapiens	NCI-H441	IC50	672.92	nM	10.6019/CHEMBL1201861
Homo sapiens	NCI-H446	IC50	11165.82	nM	10.6019/CHEMBL1201861
Homo sapiens	NCI-H460	Activity	nan	None	10.1021/acs.jmedchem.7b01775
Homo sapiens	NCI-H460	GI50	27.99	nM	None
Homo sapiens	NCI-H460	IC50	9.5	nM	10.1021/jm9505122
Homo sapiens	NCI-H460	IC50	28.0	nM	10.1021/jm9606453
Homo sapiens	NCI-H460	IC50	28.0	nM	10.1021/jm980477+
Homo sapiens	NCI-H510A	IC50	4791.54	nM	10.6019/CHEMBL1201861
Homo sapiens	NCI-H520	IC50	1389.32	nM	10.6019/CHEMBL1201861
Homo sapiens	NCI-H522	GI50	250.03	nM	None
Homo sapiens	NCI-H522	IC50	229.0	nM	10.1021/jm9606453
Homo sapiens	NCI-H522	IC50	450.0	nM	10.1021/jm980477+
Homo sapiens	NCI-H526	IC50	0.6915	nM	10.6019/CHEMBL1201861
Homo sapiens	NCI-H596	IC50	833.44	nM	10.6019/CHEMBL1201861
Homo sapiens	NCI-H630	IC50	6518.61	nM	10.6019/CHEMBL1201861
Homo sapiens	NCI-H650	IC50	807.79	nM	10.6019/CHEMBL1201861
Homo sapiens	NCI-H661	IC50	3562.87	nM	10.6019/CHEMBL1201861
Homo sapiens	NCI-H727	IC50	1127.99	nM	10.6019/CHEMBL1201861
Homo sapiens	NCI-H747	IC50	13077.3	nM	10.6019/CHEMBL1201861
Homo sapiens	NCI-H810	IC50	14315.86	nM	10.6019/CHEMBL1201861
Homo sapiens	NCI-H82	IC50	789.92	nM	10.6019/CHEMBL1201861
Homo sapiens	NCI-N87	IC50	6032.26	nM	10.6019/CHEMBL1201861
Homo sapiens	NEC8	IC50	289.76	nM	10.6019/CHEMBL1201861
Homo sapiens	Neurokinin 1 receptor	IC50	nan	None	None
Homo sapiens	Neurokinin 1 receptor	Ki	nan	None	None
Homo sapiens	Neurokinin 2 receptor	IC50	nan	None	None
Homo sapiens	Neurokinin 2 receptor	Ki	nan	None	None
Homo sapiens	Neuronal acetylcholine receptor protein alpha-4 subunit	AC50	10000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Neuropeptide Y receptor type 1	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Neuropeptide Y receptor type 1	IC50	nan	None	None
Homo sapiens	Neuropeptide Y receptor type 1	Ki	nan	None	None
Homo sapiens	Neuropeptide Y receptor type 2	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Neuropeptide Y receptor type 2	IC50	nan	None	None
Homo sapiens	Neuropeptide Y receptor type 2	Ki	nan	None	None
Homo sapiens	Neurotensin receptor 1	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	NH-12	IC50	3506.5	nM	10.6019/CHEMBL1201861
Homo sapiens	NKM-1	IC50	7.702	nM	10.6019/CHEMBL1201861
Homo sapiens	NMC-G1	IC50	11348.21	nM	10.6019/CHEMBL1201861
Homo sapiens	no-10	IC50	7307.21	nM	10.6019/CHEMBL1201861
Homo sapiens	no-11	IC50	11195.57	nM	10.6019/CHEMBL1201861
Homo sapiens	NOMO-1	IC50	16.25	nM	10.6019/CHEMBL1201861
Homo sapiens	Norepinephrine transporter	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Norepinephrine transporter	IC50	nan	None	None
Homo sapiens	Norepinephrine transporter	Ki	nan	None	None
Homo sapiens	NOS-1	IC50	4555.51	nM	10.6019/CHEMBL1201861
Homo sapiens	NTERA-2-cl-D1	IC50	3148.74	nM	10.6019/CHEMBL1201861
Homo sapiens	Nuclear factor erythroid 2-related factor 2	Potency	153.6	nM	None
Homo sapiens	Nuclear factor erythroid 2-related factor 2	Potency	580.5	nM	None
Homo sapiens	Nuclear factor erythroid 2-related factor 2	Potency	1458.1	nM	None
Homo sapiens	Nuclear receptor coactivator 1	IC50	35879.0	nM	None
Homo sapiens	Nuclear receptor coactivator 3	IC50	210.97	nM	None
Homo sapiens	NUGC-3	IC50	6122.5	nM	10.6019/CHEMBL1201861
Homo sapiens	NY	IC50	722.99	nM	10.6019/CHEMBL1201861
Homo sapiens	OAW-28	IC50	13852.46	nM	10.6019/CHEMBL1201861
Homo sapiens	OAW-42	IC50	8417.44	nM	10.6019/CHEMBL1201861
Homo sapiens	OC-314	IC50	686.05	nM	10.6019/CHEMBL1201861
Homo sapiens	OCI-AML2	IC50	265.63	nM	10.6019/CHEMBL1201861
Homo sapiens	OCUB-M	IC50	22246.22	nM	10.6019/CHEMBL1201861
Homo sapiens	OE19	IC50	1544.6	nM	10.6019/CHEMBL1201861
Homo sapiens	OE33	IC50	281.67	nM	10.6019/CHEMBL1201861
Homo sapiens	OMC-1	IC50	24621.18	nM	10.6019/CHEMBL1201861
Homo sapiens	ONS-76	IC50	63.77	nM	10.6019/CHEMBL1201861
Homo sapiens	OS-RC-2	IC50	5320.83	nM	10.6019/CHEMBL1201861
Homo sapiens	OVCAR-3	GI50	432.51	nM	None
Homo sapiens	OVCAR-3	IC50	398.0	nM	10.1021/jm9606453
Homo sapiens	OVCAR-3	IC50	400.0	nM	10.1021/jm980477+
Homo sapiens	OVCAR-3	IC50	810.02	nM	10.6019/CHEMBL1201861
Homo sapiens	OVCAR-4	GI50	2.512	nM	10.1016/j.ejmech.2007.03.035
Homo sapiens	OVCAR-4	GI50	59566.21	nM	None
Homo sapiens	OVCAR-4	IC50	1000.0	nM	10.1021/jm980477+
Homo sapiens	OVCAR-4	IC50	4414.18	nM	10.6019/CHEMBL1201861
Homo sapiens	OVCAR-5	GI50	916.22	nM	None
Homo sapiens	OVCAR-5	IC50	980.0	nM	10.1021/jm980477+
Homo sapiens	OVCAR-5	IC50	1000.0	nM	10.1021/jm9606453
Homo sapiens	OVCAR-5	IC50	14668.74	nM	10.6019/CHEMBL1201861
Homo sapiens	OVCAR-8	GI50	29.24	nM	None
Homo sapiens	OVCAR-8	IC50	31.0	nM	10.1021/jm9606453
Homo sapiens	OVCAR-8	IC50	31.0	nM	10.1021/jm980477+
Homo sapiens	OVCAR-8	IC50	9990.71	nM	10.6019/CHEMBL1201861
Homo sapiens	P12-Ichikawa	IC50	41.3	nM	10.6019/CHEMBL1201861
Homo sapiens	P30-OHK	IC50	43.55	nM	10.6019/CHEMBL1201861
Homo sapiens	PA-1	IC50	9897.78	nM	10.6019/CHEMBL1201861
Homo sapiens	PANC-03-27	IC50	7927.15	nM	10.6019/CHEMBL1201861
Homo sapiens	PANC-08-13	IC50	3886.13	nM	10.6019/CHEMBL1201861
Homo sapiens	Panc1005	IC50	4317.58	nM	10.6019/CHEMBL1201861
Homo sapiens	Panel NCI-60 (60 carcinoma cell lines)	GI50	5.55	None	10.1021/jm051029m
Homo sapiens	PC-14	IC50	572.86	nM	10.6019/CHEMBL1201861
Homo sapiens	PC-3	GI50	86.5	nM	None
Homo sapiens	PC-3	GI50	100.0	nM	10.1016/j.ejmech.2010.11.013
Homo sapiens	PC-3	IC50	0.027	ug.mL-1	10.1021/jm0701977
Homo sapiens	PC-3	IC50	1.0	nM	10.1016/j.bmc.2010.05.072
Homo sapiens	PC-3	IC50	2.0	nM	10.1021/jm9606453
Homo sapiens	PC-3	IC50	27.0	nM	10.1021/jm980477+
Homo sapiens	PC-3	IC50	2637.41	nM	10.6019/CHEMBL1201861
Homo sapiens	PC-3	IC50	28780.0	nM	10.1016/j.ejmech.2022.114661
Homo sapiens	PC-3	IC50	nan	None	10.1021/np500836y
Homo sapiens	PC-3	LC50	100000.0	nM	10.1016/j.ejmech.2010.11.013
Homo sapiens	PC-3	TGI	100000.0	nM	10.1016/j.ejmech.2010.11.013
Homo sapiens	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	Potency	23934.1	nM	None
Homo sapiens	Peroxisome proliferator-activated receptor delta	Potency	1412.5	nM	None
Homo sapiens	Peroxisome proliferator-activated receptor gamma	Potency	281.8	nM	None
Homo sapiens	Peroxisome proliferator-activated receptor gamma	Potency	446.7	nM	None
Homo sapiens	PFSK-1	IC50	1206.31	nM	10.6019/CHEMBL1201861
Homo sapiens	P-glycoprotein 1	Activity	nan	None	10.1002/(sici)1097-0215(19960301)65:5<613::aid-ijc10>3.0.co;2-8
Homo sapiens	P-glycoprotein 1	% maximum response	4.25	%	None
Homo sapiens	P-glycoprotein 1	Papp	7.06	nm/s	None
Homo sapiens	P-glycoprotein 1	Papp	10.5	nm/s	None
Homo sapiens	P-glycoprotein 1	Ratio_ATPase activity	0.91	None	None
Homo sapiens	P-glycoprotein 1	Ratio_Papp	0.67	None	None
Homo sapiens	Phosphodiesterase 3A	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Phosphodiesterase 4D	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Phosphodiesterase 5A	IC50	nan	None	None
Homo sapiens	Phosphodiesterase 5A	Ki	nan	None	None
Homo sapiens	Plasma	fCmax	2.348	uM	10.1124/dmd.111.040758
Homo sapiens	Plasma	K(p,uu,CSF)	0.062	None	10.1021/jm901036q
Homo sapiens	Platelet activating factor receptor	IC50	nan	None	None
Homo sapiens	Platelet activating factor receptor	Ki	nan	None	None
Homo sapiens	PPC-1	IC50	10.0	nM	10.1016/j.bmc.2006.11.017
Homo sapiens	PPC-1	IC50	100.0	nM	10.1016/j.bmc.2006.11.017
Homo sapiens	Pregnane X receptor	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Prelamin-A/C	Potency	4.5	nM	None
Homo sapiens	Prelamin-A/C	Potency	28.2	nM	None
Homo sapiens	Prelamin-A/C	Potency	177.8	nM	None
Homo sapiens	Progesterone receptor	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Protein-arginine deiminase type-4	IC50	10000000.0	nM	10.1016/j.bmc.2007.10.021
Homo sapiens	Protein kinase C alpha	IC50	nan	None	None
Homo sapiens	Protein kinase C alpha	Ki	nan	None	None
Homo sapiens	Proton-coupled folate transporter	IC50	120.5	nM	10.1021/jm501113m
Homo sapiens	Proton-coupled folate transporter	IC50	121.0	nM	10.1021/acs.jmedchem.7b01708
Homo sapiens	PSN1	IC50	1586.64	nM	10.6019/CHEMBL1201861
Homo sapiens	QIMR-WIL	IC50	139.41	nM	10.6019/CHEMBL1201861
Homo sapiens	R1-CCRF-CEM	EC50	565.0	nM	10.1021/jm058276a
Homo sapiens	R1-CCRF-CEM	EC50	985.0	nM	10.1021/jm0203534
Homo sapiens	R2	EC50	2100.0	nM	10.1021/jm040144e
Homo sapiens	R2	EC50	2600.0	nM	10.1021/jm010575m
Homo sapiens	R2	IC50	120.5	nM	10.1021/jm401328u
Homo sapiens	R2	IC50	121.0	nM	10.1021/jm200739e
Homo sapiens	R2	IC50	121.0	nM	10.1021/jm401139z
Homo sapiens	R2	IC50	216.0	nM	10.1021/jm200739e
Homo sapiens	R2	IC50	216.0	nM	10.1021/jm501113m
Homo sapiens	R2	IC50	216.0	nM	10.1021/jm8003366
Homo sapiens	R2	IC50	1000.0	nM	10.1021/jm501113m
Homo sapiens	R2-CCRF-CEM	EC50	1700.0	nM	10.1021/jm058276a
Homo sapiens	R2-CCRF-CEM	EC50	2630.0	nM	10.1021/jm0203534
Homo sapiens	R30dm-CCRF-CEM	EC50	12.8	nM	10.1021/jm0203534
Homo sapiens	R30dm-CCRF-CEM	EC50	18.0	nM	10.1021/jm00034a015
Homo sapiens	Raji	IC50	40.0	nM	10.1016/j.bmc.2008.05.022
Homo sapiens	Raji	ID50	0.02	uM	10.1021/jm00083a017
Homo sapiens	Ramos-2G6-4C10	IC50	26.86	nM	10.6019/CHEMBL1201861
Homo sapiens	RCC10RGB	IC50	20210.19	nM	10.6019/CHEMBL1201861
Homo sapiens	RCM-1	IC50	1461.39	nM	10.6019/CHEMBL1201861
Homo sapiens	RD	IC50	8437.19	nM	10.6019/CHEMBL1201861
Homo sapiens	Receptor protein-tyrosine kinase erbB-2	IC50	nan	None	None
Homo sapiens	Receptor protein-tyrosine kinase erbB-2	Ki	nan	None	None
Homo sapiens	RERF-LC-MS	IC50	1110.7	nM	10.6019/CHEMBL1201861
Homo sapiens	Retinoid X receptor alpha	Potency	112.2	nM	None
Homo sapiens	RH-1	IC50	361.82	nM	10.6019/CHEMBL1201861
Homo sapiens	RH-18	IC50	15800.38	nM	10.6019/CHEMBL1201861
Homo sapiens	RKO	IC50	4762.89	nM	10.6019/CHEMBL1201861
Homo sapiens	RMG-I	IC50	10692.98	nM	10.6019/CHEMBL1201861
Homo sapiens	RO82-W-1	IC50	7240.89	nM	10.6019/CHEMBL1201861
Homo sapiens	RPMI-2650	IC50	6187.82	nM	10.6019/CHEMBL1201861
Homo sapiens	RPMI-7951	IC50	1952.97	nM	10.6019/CHEMBL1201861
Homo sapiens	RPMI-8226	GI50	66.07	nM	None
Homo sapiens	RPMI-8226	IC50	33.0	nM	10.1021/jm980477+
Homo sapiens	RPMI-8226	IC50	101.2	nM	10.6019/CHEMBL1201861
Homo sapiens	RPMI-8866	IC50	19.99	nM	10.6019/CHEMBL1201861
Homo sapiens	RS4-11	IC50	7.05	nM	10.6019/CHEMBL1201861
Homo sapiens	RT-112	IC50	142.31	nM	10.6019/CHEMBL1201861
Homo sapiens	RT-4	IC50	40.0	nM	10.1021/jm801522j
Homo sapiens	Runt-related transcription factor 1/Core-binding factor subunit beta	Potency	14125.4	nM	None
Homo sapiens	Runt-related transcription factor 1/Core-binding factor subunit beta	Potency	44668.4	nM	None
Homo sapiens	RVH-421	IC50	23044.27	nM	10.6019/CHEMBL1201861
Homo sapiens	RXF 393	GI50	20653.8	nM	None
Homo sapiens	RXF 393	IC50	1000.0	nM	10.1021/jm980477+
Homo sapiens	RXF 393	IC50	13852.68	nM	10.6019/CHEMBL1201861
Homo sapiens	RXF 631	GI50	44.06	nM	None
Homo sapiens	S-117	IC50	10816.64	nM	10.6019/CHEMBL1201861
Homo sapiens	SAOS-2	IC50	2963.6	nM	10.6019/CHEMBL1201861
Homo sapiens	SAS	IC50	3937.81	nM	10.6019/CHEMBL1201861
Homo sapiens	SBC-1	IC50	563.79	nM	10.6019/CHEMBL1201861
Homo sapiens	SBC-5	IC50	69.36	nM	10.6019/CHEMBL1201861
Homo sapiens	SCC-15	IC50	38.0	nM	10.1021/jm00402a013
Homo sapiens	SCC-15	IC50	580.0	nM	10.1021/jm00402a013
Homo sapiens	SCC-15	IC50	805.09	nM	10.6019/CHEMBL1201861
Homo sapiens	SCC-25	IC50	7.5	nM	10.1021/jm00040a008
Homo sapiens	SCC-25	IC50	7.5	nM	10.1021/jm00402a013
Homo sapiens	SCC-25	IC50	27.0	nM	10.1021/jm9606453
Homo sapiens	SCC-25	IC50	150.0	nM	10.1021/jm00402a013
Homo sapiens	SCC-25	IC50	6594.15	nM	10.6019/CHEMBL1201861
Homo sapiens	SCC-4	IC50	7609.07	nM	10.6019/CHEMBL1201861
Homo sapiens	SCC-9	IC50	7433.44	nM	10.6019/CHEMBL1201861
Homo sapiens	SCH	IC50	984.47	nM	10.6019/CHEMBL1201861
Homo sapiens	Serine/threonine protein phosphatase 2B catalytic subunit, alpha isoform	IC50	nan	None	None
Homo sapiens	Serine/threonine protein phosphatase 2B catalytic subunit, alpha isoform	Ki	nan	None	None
Homo sapiens	Serotonin 1a (5-HT1a) receptor	AC50	10000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Serotonin 2a (5-HT2a) receptor	AC50	10000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Serotonin 2a (5-HT2a) receptor	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Serotonin 2a (5-HT2a) receptor	IC50	nan	None	None
Homo sapiens	Serotonin 2a (5-HT2a) receptor	Ki	nan	None	None
Homo sapiens	Serotonin 2b (5-HT2b) receptor	AC50	10000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Serotonin 2b (5-HT2b) receptor	IC50	nan	None	None
Homo sapiens	Serotonin 2b (5-HT2b) receptor	Ki	nan	None	None
Homo sapiens	Serotonin 2c (5-HT2c) receptor	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Serotonin 2c (5-HT2c) receptor	IC50	nan	None	None
Homo sapiens	Serotonin 2c (5-HT2c) receptor	Ki	nan	None	None
Homo sapiens	Serotonin 3a (5-HT3a) receptor	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Serotonin 6 (5-HT6) receptor	IC50	nan	None	None
Homo sapiens	Serotonin 6 (5-HT6) receptor	Ki	nan	None	None
Homo sapiens	Serotonin transporter	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Serotonin transporter	IC50	nan	None	None
Homo sapiens	Serotonin transporter	Ki	nan	None	None
Homo sapiens	Serum	Retention_time	2.0	min	10.1021/jm00202a013
Homo sapiens	Serum albumin	K	820.0	/M	10.1039/d0md00051e
Homo sapiens	Serum albumin	Log K'	0.77	None	10.1021/jm010960b
Homo sapiens	SF-126	IC50	17962.51	nM	10.6019/CHEMBL1201861
Homo sapiens	SF-268	GI50	40.93	nM	None
Homo sapiens	SF-268	IC50	52.0	nM	10.1021/jm9606453
Homo sapiens	SF-268	IC50	52.0	nM	10.1021/jm980477+
Homo sapiens	SF-268	IC50	427.97	nM	10.6019/CHEMBL1201861
Homo sapiens	SF-295	GI50	38.28	nM	None
Homo sapiens	SF-295	IC50	36.0	nM	10.1021/jm980477+
Homo sapiens	SF-295	IC50	12419.8	nM	10.6019/CHEMBL1201861
Homo sapiens	SF-539	GI50	37.5	nM	None
Homo sapiens	SF-539	IC50	35.0	nM	10.1021/jm9606453
Homo sapiens	SF-539	IC50	35.0	nM	10.1021/jm980477+
Homo sapiens	SF-539	IC50	19090.24	nM	10.6019/CHEMBL1201861
Homo sapiens	SH-4	IC50	6942.67	nM	10.6019/CHEMBL1201861
Homo sapiens	SHP77	IC50	1914.59	nM	10.6019/CHEMBL1201861
Homo sapiens	Sialin	Inhibition	nan	%	10.1021/acs.jmedchem.9b02119
Homo sapiens	Sigma opioid receptor	IC50	nan	None	None
Homo sapiens	Sigma opioid receptor	Ki	nan	None	None
Homo sapiens	SiHa	IC50	8502.33	nM	10.6019/CHEMBL1201861
Homo sapiens	SJSA-1	IC50	15658.5	nM	10.6019/CHEMBL1201861
Homo sapiens	SKG-IIIa	IC50	6786.83	nM	10.6019/CHEMBL1201861
Homo sapiens	SK-HEP1	IC50	1053.35	nM	10.6019/CHEMBL1201861
Homo sapiens	SK-LU-1	IC50	7598.39	nM	10.6019/CHEMBL1201861
Homo sapiens	SK-MEL-1	IC50	500.44	nM	10.6019/CHEMBL1201861
Homo sapiens	SK-MEL-2	GI50	101624.87	nM	None
Homo sapiens	SK-MEL-2	IC50	1000.0	nM	10.1021/jm980477+
Homo sapiens	SK-MEL-2	IC50	17057.62	nM	10.6019/CHEMBL1201861
Homo sapiens	SK-MEL-24	IC50	1056.05	nM	10.6019/CHEMBL1201861
Homo sapiens	SK-MEL-28	GI50	4864.07	nM	None
Homo sapiens	SK-MEL-28	IC50	1000.0	nM	10.1021/jm9606453
Homo sapiens	SK-MEL-28	IC50	1000.0	nM	10.1021/jm980477+
Homo sapiens	SK-MEL-28	IC50	7394.01	nM	10.6019/CHEMBL1201861
Homo sapiens	SK-MEL3	IC50	1055.93	nM	10.6019/CHEMBL1201861
Homo sapiens	SK-MEL-30	IC50	3851.21	nM	10.6019/CHEMBL1201861
Homo sapiens	SK-MEL-5	GI50	89.95	nM	None
Homo sapiens	SK-MEL-5	IC50	87.0	nM	10.1021/jm9606453
Homo sapiens	SK-MEL-5	IC50	87.0	nM	10.1021/jm980477+
Homo sapiens	SK-MES-1	IC50	5069.11	nM	10.6019/CHEMBL1201861
Homo sapiens	SK-N-AS	IC50	1417.83	nM	10.6019/CHEMBL1201861
Homo sapiens	SK-N-DZ	IC50	743.08	nM	10.6019/CHEMBL1201861
Homo sapiens	SK-NEP-1	IC50	4.819	nM	10.6019/CHEMBL1201861
Homo sapiens	SK-N-FI	IC50	13184.17	nM	10.6019/CHEMBL1201861
Homo sapiens	SK-OV-3	GI50	20701.41	nM	None
Homo sapiens	SK-OV-3	IC50	60.0	nM	10.1016/j.ejmech.2012.09.027
Homo sapiens	SK-PN-DW	IC50	8356.61	nM	10.6019/CHEMBL1201861
Homo sapiens	SK-UT-1	IC50	12169.67	nM	10.6019/CHEMBL1201861
Homo sapiens	SN12C	GI50	32.14	nM	None
Homo sapiens	SN12C	IC50	5554.32	nM	10.6019/CHEMBL1201861
Homo sapiens	SN12K1	GI50	25.0	nM	None
Homo sapiens	SNB-19	GI50	590.2	nM	None
Homo sapiens	SNB-7	IC50	60.0	ug.mL-1	10.1021/jm0701977
Homo sapiens	SNB-75	GI50	21677.04	nM	None
Homo sapiens	SNB-75	IC50	1000.0	nM	10.1021/jm9606453
Homo sapiens	SNB-75	IC50	24775.05	nM	10.6019/CHEMBL1201861
Homo sapiens	SNB-78	GI50	117219.54	nM	None
Homo sapiens	SNU1	IC50	7.515	nM	10.6019/CHEMBL1201861
Homo sapiens	SNU-387	IC50	12342.58	nM	10.6019/CHEMBL1201861
Homo sapiens	SNU-423	IC50	16346.99	nM	10.6019/CHEMBL1201861
Homo sapiens	SNU-449	IC50	827.35	nM	10.6019/CHEMBL1201861
Homo sapiens	SNU-5	IC50	1499.68	nM	10.6019/CHEMBL1201861
Homo sapiens	SNU-C2B	IC50	144.74	nM	10.6019/CHEMBL1201861
Homo sapiens	Solute carrier family 22 member 1	Inhibition	26.3	%	10.1021/jm8003152
Homo sapiens	Solute carrier family 22 member 11	Km	17800.0	nM	10.1124/jpet.102.034330
Homo sapiens	Solute carrier family 22 member 6	Activity	nan	None	10.1038/nrd3028
Homo sapiens	Solute carrier family 22 member 6	Activity	nan	None	10.1152/ajprenal.1999.276.2.f295
Homo sapiens	Solute carrier family 22 member 6	Km	553800.0	nM	10.1124/jpet.102.034330
Homo sapiens	Solute carrier family 22 member 7	Activity	nan	None	10.1006/bbrc.2001.4774
Homo sapiens	Solute carrier family 22 member 8	Km	10900.0	nM	10.1124/mol.59.5.1277
Homo sapiens	Solute carrier family 22 member 8	Km	21100.0	nM	10.1124/jpet.102.034330
Homo sapiens	Solute carrier organic anion transporter family member 1A2	Activity	nan	None	10.1038/nrd3028
Homo sapiens	Solute carrier organic anion transporter family member 1B1	Activity	nan	None	10.1053/gast.2001.24804
Homo sapiens	Solute carrier organic anion transporter family member 1B1	Inhibition	27.4	%	10.1021/jm300212s
Homo sapiens	Solute carrier organic anion transporter family member 1B3	Activity	12.0	%	10.1016/j.ejmech.2015.01.011
Homo sapiens	Solute carrier organic anion transporter family member 1B3	Inhibition	17.2	%	10.1021/jm300212s
Homo sapiens	Solute carrier organic anion transporter family member 1B3	Km	24700.0	nM	10.1053/gast.2001.24804
Homo sapiens	Solute carrier organic anion transporter family member 1C1	Activity	nan	None	10.1210/me.2001-0309
Homo sapiens	Solute carrier organic anion transporter family member 2B1	Inhibition	-13.4	%	10.1021/jm300212s
Homo sapiens	Solute carrier organic anion transporter family member 3A1	Activity	nan	None	10.1152/ajprenal.00402.2002
Homo sapiens	Sphingomyelin phosphodiesterase	Potency	31622.8	nM	None
Homo sapiens	SR	GI50	37.33	nM	None
Homo sapiens	SR	IC50	33.0	nM	10.1021/jm980477+
Homo sapiens	Survival motor neuron protein	Potency	89.1	nM	None
Homo sapiens	Survival motor neuron protein	Potency	141.3	nM	None
Homo sapiens	SW1088	IC50	6443.97	nM	10.6019/CHEMBL1201861
Homo sapiens	SW 1116	IC50	2490.0	nM	10.1016/j.ejmech.2019.06.036
Homo sapiens	SW 1116	IC50	12884.1	nM	10.6019/CHEMBL1201861
Homo sapiens	SW13	IC50	8043.7	nM	10.6019/CHEMBL1201861
Homo sapiens	SW1417	IC50	1913.34	nM	10.6019/CHEMBL1201861
Homo sapiens	SW1463	IC50	11376.93	nM	10.6019/CHEMBL1201861
Homo sapiens	SW1573	IC50	11519.79	nM	10.6019/CHEMBL1201861
Homo sapiens	SW1710	IC50	5961.88	nM	10.6019/CHEMBL1201861
Homo sapiens	SW1783	IC50	15764.74	nM	10.6019/CHEMBL1201861
Homo sapiens	SW1990	IC50	18063.1	nM	10.6019/CHEMBL1201861
Homo sapiens	SW48	IC50	12952.45	nM	10.6019/CHEMBL1201861
Homo sapiens	SW480	IC50	15.0	nM	10.1021/jm00368a023
Homo sapiens	SW480	IC50	15.0	nM	10.1021/jm00391a042
Homo sapiens	SW-620	GI50	38.82	nM	None
Homo sapiens	SW-620	IC50	13.1	nM	10.1016/j.ejmech.2019.06.013
Homo sapiens	SW-620	IC50	22.0	nM	10.1016/j.ejmech.2017.08.032
Homo sapiens	SW-620	IC50	33.0	nM	10.1021/jm9606453
Homo sapiens	SW-620	IC50	541.93	nM	10.6019/CHEMBL1201861
Homo sapiens	SW626	IC50	16469.27	nM	10.6019/CHEMBL1201861
Homo sapiens	SW684	IC50	9281.87	nM	10.6019/CHEMBL1201861
Homo sapiens	SW756	IC50	13860.85	nM	10.6019/CHEMBL1201861
Homo sapiens	SW780	IC50	116.29	nM	10.6019/CHEMBL1201861
Homo sapiens	SW837	IC50	4590.68	nM	10.6019/CHEMBL1201861
Homo sapiens	SW872	IC50	4600.2	nM	10.6019/CHEMBL1201861
Homo sapiens	SW900	IC50	11239.92	nM	10.6019/CHEMBL1201861
Homo sapiens	SW948	IC50	18626.92	nM	10.6019/CHEMBL1201861
Homo sapiens	SW 954	IC50	213.15	nM	10.6019/CHEMBL1201861
Homo sapiens	SW 962	IC50	12996.33	nM	10.6019/CHEMBL1201861
Homo sapiens	SW982	IC50	11016.95	nM	10.6019/CHEMBL1201861
Homo sapiens	T-24	IC50	13954.82	nM	10.6019/CHEMBL1201861
Homo sapiens	T47D	Activity	nan	None	10.1021/acs.jmedchem.6b00043
Homo sapiens	T47D	GI50	27989.81	nM	None
Homo sapiens	T47D	IC50	0.16	ug.mL-1	10.1007/s00044-013-0773-3
Homo sapiens	T47D	IC50	0.16	ug.mL-1	10.1016/j.ejmech.2010.08.063
Homo sapiens	T47D	IC50	1000.0	nM	10.1021/jm980477+
Homo sapiens	T47D	IC50	15000.0	nM	10.1021/acs.jmedchem.6b00043
Homo sapiens	T47D	IC50	15848.93	nM	10.1021/acs.jmedchem.6b00043
Homo sapiens	T47D	IC50	24878.35	nM	10.6019/CHEMBL1201861
Homo sapiens	T47D	Inhibition	53.8	%	10.1016/j.ejmech.2019.111965
Homo sapiens	T84	IC50	17536.83	nM	10.6019/CHEMBL1201861
Homo sapiens	T98G	IC50	12845.93	nM	10.6019/CHEMBL1201861
Homo sapiens	TAR DNA-binding protein 43	Potency	1258.9	nM	None
Homo sapiens	TCC-SUP	IC50	8569.61	nM	10.6019/CHEMBL1201861
Homo sapiens	TE-1	IC50	388.24	nM	10.6019/CHEMBL1201861
Homo sapiens	TE-10	IC50	12658.54	nM	10.6019/CHEMBL1201861
Homo sapiens	TE-11	IC50	773.21	nM	10.6019/CHEMBL1201861
Homo sapiens	TE-12	IC50	510.68	nM	10.6019/CHEMBL1201861
Homo sapiens	TE-5	IC50	11992.34	nM	10.6019/CHEMBL1201861
Homo sapiens	TE-6	IC50	11032.73	nM	10.6019/CHEMBL1201861
Homo sapiens	TE-8	IC50	8756.99	nM	10.6019/CHEMBL1201861
Homo sapiens	TE-9	IC50	3470.42	nM	10.6019/CHEMBL1201861
Homo sapiens	TGBC11TKB	IC50	18254.62	nM	10.6019/CHEMBL1201861
Homo sapiens	TGBC1TKB	IC50	7617.41	nM	10.6019/CHEMBL1201861
Homo sapiens	TGBC24TKB	IC50	4585.3	nM	10.6019/CHEMBL1201861
Homo sapiens	Thromboxane A2 receptor	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Thromboxane-A synthase	IC50	nan	None	None
Homo sapiens	Thromboxane-A synthase	Ki	nan	None	None
Homo sapiens	Thymidylate synthase	IC50	3600.0	nM	10.1021/jm0100382
Homo sapiens	Thymidylate synthase	IC50	18000.0	nM	10.1016/j.bmc.2011.03.067
Homo sapiens	Thymidylate synthase	IC50	29000.0	nM	10.1016/j.bmc.2009.11.029
Homo sapiens	Thymidylate synthase	IC50	29000.0	nM	10.1021/jm058234m
Homo sapiens	Thymidylate synthase	IC50	29000.0	nM	10.1021/jm800244v
Homo sapiens	Thymidylate synthase	IC50	120000.0	nM	10.1021/jm00159a032
Homo sapiens	Thymidylate synthase	IC50	170000.0	nM	10.1021/jm00019a009
Homo sapiens	Thymidylate synthase	IC50	170000.0	nM	10.1021/jm00034a015
Homo sapiens	Thymidylate synthase	IC50	nan	nM	10.1021/jm058213s
Homo sapiens	Thymidylate synthase	IC50	nan	None	10.1021/jm000130i
Homo sapiens	Thymidylate synthase	IC50	nan	None	10.1021/jm040123k
Homo sapiens	Thymidylate synthase	IC50	nan	None	10.1021/jm040144e
Homo sapiens	Thymidylate synthase	IC50	nan	None	10.1021/jm058276a
Homo sapiens	Thymidylate synthase	IC50	nan	None	10.1021/jm701052u
Homo sapiens	Thymidylate synthase	IC50	nan	None	10.1021/jm8006933
Homo sapiens	Thymidylate synthase	IC50	nan	None	10.1021/jm900490a
Homo sapiens	Thymidylate synthase	Inhibition	0.00015	%	10.1021/jm00369a024
Homo sapiens	Thymidylate synthase	Inhibition	nan	%	10.1021/jm010575m
Homo sapiens	Thymidylate synthase	Ki	600.0	nM	10.1021/jm300563f
Homo sapiens	Thymidylate synthase/GAR transformylase/AICAR transformylase	IC50	10.0	nM	10.1016/j.ejmech.2017.08.032
Homo sapiens	TI-73	IC50	11605.08	nM	10.6019/CHEMBL1201861
Homo sapiens	TK-10	GI50	37411.06	nM	None
Homo sapiens	TK-10	IC50	1000.0	nM	10.1021/jm980477+
Homo sapiens	TK-10	IC50	26849.52	nM	10.6019/CHEMBL1201861
Homo sapiens	Toll-like receptor 4	IC50	1040.0	nM	10.1016/j.bmcl.2021.128315
Homo sapiens	Transcriptional regulator ERG	Potency	39810.7	nM	None
Homo sapiens	TYK-nu	IC50	197.27	nM	10.6019/CHEMBL1201861
Homo sapiens	Type-1 angiotensin II receptor	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Tyrosine-protein kinase FYN	IC50	nan	None	None
Homo sapiens	Tyrosine-protein kinase FYN	Ki	nan	None	None
Homo sapiens	Tyrosine-protein kinase LCK	IC50	nan	None	None
Homo sapiens	Tyrosine-protein kinase LCK	Ki	nan	None	None
Homo sapiens	Tyrosyl-DNA phosphodiesterase 1	Potency	10.3	nM	None
Homo sapiens	Tyrosyl-DNA phosphodiesterase 1	Potency	10.6	nM	None
Homo sapiens	Tyrosyl-DNA phosphodiesterase 1	Potency	21.1	nM	None
Homo sapiens	Tyrosyl-DNA phosphodiesterase 1	Potency	22.4	nM	None
Homo sapiens	Tyrosyl-DNA phosphodiesterase 1	Potency	41.1	nM	None
Homo sapiens	Tyrosyl-DNA phosphodiesterase 1	Potency	59.6	nM	None
Homo sapiens	Tyrosyl-DNA phosphodiesterase 1	Potency	125.9	nM	None
Homo sapiens	Tyrosyl-DNA phosphodiesterase 1	Potency	63095.7	nM	None
Homo sapiens	Tyrosyl-DNA phosphodiesterase 1	Potency	89125.1	nM	None
Homo sapiens	U-118-MG	IC50	4671.36	nM	10.6019/CHEMBL1201861
Homo sapiens	U-251	GI50	72.28	nM	None
Homo sapiens	U-251	IC50	63.0	nM	10.1021/jm980477+
Homo sapiens	U-251	IC50	12192.83	nM	10.6019/CHEMBL1201861
Homo sapiens	U-266	IC50	5528.57	nM	10.6019/CHEMBL1201861
Homo sapiens	U2OS	IC50	182.32	nM	10.6019/CHEMBL1201861
Homo sapiens	U373 MG	IC50	12.0	nM	10.1021/jm9505122
Homo sapiens	U-87 MG	IC50	22.0	nM	10.1021/jm9505122
Homo sapiens	U-87 MG	IC50	18560.6	nM	10.6019/CHEMBL1201861
Homo sapiens	UACC-257	GI50	835.6	nM	None
Homo sapiens	UACC-257	IC50	790.0	nM	10.1021/jm980477+
Homo sapiens	UACC-257	IC50	19229.51	nM	10.6019/CHEMBL1201861
Homo sapiens	UACC-62	GI50	28.58	nM	None
Homo sapiens	UACC-62	IC50	28.0	nM	10.1021/jm9606453
Homo sapiens	UACC-62	IC50	28.0	nM	10.1021/jm980477+
Homo sapiens	UACC-62	IC50	17915.82	nM	10.6019/CHEMBL1201861
Homo sapiens	UACC-893	IC50	1095.12	nM	10.6019/CHEMBL1201861
Homo sapiens	Ubiquitin carboxyl-terminal hydrolase 1	Potency	56234.1	nM	None
Homo sapiens	UMC-11	IC50	9583.54	nM	10.6019/CHEMBL1201861
Homo sapiens	UMUC3	IC50	7035.19	nM	10.6019/CHEMBL1201861
Homo sapiens	UO-31	GI50	226.99	nM	None
Homo sapiens	UO-31	IC50	191.0	nM	10.1021/jm9606453
Homo sapiens	UO-31	IC50	3643.4	nM	10.6019/CHEMBL1201861
Homo sapiens	VA-ES-BJ	IC50	5058.84	nM	10.6019/CHEMBL1201861
Homo sapiens	Vascular endothelial growth factor receptor 1	IC50	nan	None	None
Homo sapiens	Vascular endothelial growth factor receptor 1	Ki	nan	None	None
Homo sapiens	Vasoactive intestinal polypeptide receptor 1	IC50	nan	None	None
Homo sapiens	Vasoactive intestinal polypeptide receptor 1	Ki	nan	None	None
Homo sapiens	Vasopressin V1a receptor	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Vasopressin V1a receptor	IC50	nan	None	None
Homo sapiens	Vasopressin V1a receptor	Ki	nan	None	None
Homo sapiens	Vasopressin V2 receptor	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Vitamin D receptor	Potency	39810.7	nM	None
Homo sapiens	VM-CUB-1	IC50	374.42	nM	10.6019/CHEMBL1201861
Homo sapiens	VMRC-RCZ	IC50	5079.77	nM	10.6019/CHEMBL1201861
Homo sapiens	WiDr	IC50	25.0	nM	10.1021/jm00368a023
Homo sapiens	WiDr	IC50	25.0	nM	10.1021/jm00391a042
Homo sapiens	WM-115	IC50	1827.33	nM	10.6019/CHEMBL1201861
Homo sapiens	XF498	GI50	68548.82	nM	None
Homo sapiens	YAPC	IC50	665.75	nM	10.6019/CHEMBL1201861
Homo sapiens	YH-13	IC50	21406.55	nM	10.6019/CHEMBL1201861
Homo sapiens	YKG-1	IC50	23243.0	nM	10.6019/CHEMBL1201861
Homo sapiens	ZR-75-1	IC50	60.0	ug.mL-1	10.1021/jm0701977
Homo sapiens	ZR-75-30	IC50	2232.94	nM	10.6019/CHEMBL1201861
Lacticaseibacillus casei	Lacticaseibacillus casei	Concentration	0.01	ng ml-1	10.1021/jm00352a026
Lacticaseibacillus casei	Lacticaseibacillus casei	Concentration	500000.0	ng ml-1	10.1021/jm00352a026
Lacticaseibacillus casei	Lacticaseibacillus casei	IC50	9e-06	ug.mL-1	10.1021/jm00159a039
Lacticaseibacillus casei	Lacticaseibacillus casei	IC50	1e-05	nM	10.1021/jm00396a022
Lacticaseibacillus casei	Lacticaseibacillus casei	IC50	1e-05	ug.mL-1	10.1021/jm00141a010
Lacticaseibacillus casei	Lacticaseibacillus casei	IC50	1e-05	ug.mL-1	10.1021/jm00193a022
Lacticaseibacillus casei	Lacticaseibacillus casei	IC50	1.2e-05	ug.mL-1	10.1021/jm00156a029
Lacticaseibacillus casei	Lacticaseibacillus casei	IC50	1.3e-05	ug.mL-1	10.1021/jm00156a026
Lacticaseibacillus casei	Lacticaseibacillus casei	IC50	1.7e-05	ug.mL-1	10.1021/jm00358a030
Lacticaseibacillus casei	Lacticaseibacillus casei	IC50	2e-05	nM	10.1021/jm00126a022
Lacticaseibacillus casei	Lacticaseibacillus casei	IC50	2e-05	ug.mL-1	10.1021/jm00157a600
Lacticaseibacillus casei	Lacticaseibacillus casei	IC50	7e-05	ug.mL-1	10.1021/jm00175a011
Lacticaseibacillus casei	Lacticaseibacillus casei	IC50	0.01	nM	10.1021/jm00212a010
Lacticaseibacillus casei	Lacticaseibacillus casei	IC50	0.03	nM	10.1021/jm00159a032
Lacticaseibacillus casei	Lacticaseibacillus casei	IC50	0.03	nM	10.1021/jm00396a029
Lacticaseibacillus casei	Lacticaseibacillus casei	IC50	0.05	nM	10.1021/jm00396a022
Lacticaseibacillus casei	Lacticaseibacillus casei	IC50	0.06	nM	10.1021/jm00212a010
Lacticaseibacillus casei	Lacticaseibacillus casei	IC50	0.09	nM	10.1021/jm00396a029
Lacticaseibacillus casei	Lacticaseibacillus casei	IC50	0.18	nM	10.1021/jm00396a029
Lacticaseibacillus casei	Lacticaseibacillus casei	IC50	0.2	nM	10.1021/jm00396a029
Lacticaseibacillus casei	Lacticaseibacillus casei	IC50	0.28	nM	10.1021/jm00396a029
Lacticaseibacillus casei	Lacticaseibacillus casei	IC50	0.8	nM	10.1021/jm00396a029
Lacticaseibacillus casei	Lacticaseibacillus casei	IC50	0.85	nM	10.1021/jm00396a029
Lacticaseibacillus casei	Lacticaseibacillus casei	IC50	1.1	nM	10.1021/jm00396a029
Lacticaseibacillus casei	Lacticaseibacillus casei	IC50	2.2	nM	10.1021/jm00396a029
Lacticaseibacillus casei	Lacticaseibacillus casei	IC50	3.4	nM	10.1021/jm00396a029
Lacticaseibacillus casei	Lacticaseibacillus casei	IC50	6.0	nM	10.1021/jm00396a029
Lacticaseibacillus casei	Lacticaseibacillus casei	IC50	13.0	nM	10.1021/jm00349a024
Lacticaseibacillus casei	Lacticaseibacillus casei	IC50	27.0	nM	10.1021/jm00396a029
Lacticaseibacillus casei	Lacticaseibacillus casei	IC50	100.0	nM	10.1021/jm00396a029
Lacticaseibacillus casei	Lacticaseibacillus casei	IC50	500.0	ug.mL-1	10.1021/jm00156a029
Lacticaseibacillus casei	Lacticaseibacillus casei	IC50	500.0	ug.mL-1	10.1021/jm00157a600
Lacticaseibacillus casei	Lacticaseibacillus casei	IC50	500.0	ug.mL-1	10.1021/jm00159a039
Lacticaseibacillus casei	Lacticaseibacillus casei	IC50	500.0	ug.mL-1	10.1021/jm00175a011
Lacticaseibacillus casei	Lacticaseibacillus casei	IC50	500.0	ug.mL-1	10.1021/jm00358a030
Lacticaseibacillus casei	Lacticaseibacillus casei	IC50	560.0	nM	10.1021/jm00396a029
Lacticaseibacillus casei	Lacticaseibacillus casei	IC50	1200.0	nM	10.1021/jm00396a029
Lacticaseibacillus casei	Lacticaseibacillus casei	IC50	2600.0	nM	10.1021/jm00396a029
Lacticaseibacillus casei	Lacticaseibacillus casei	IC50	8000.0	nM	10.1021/jm00396a029
Lacticaseibacillus casei	Lacticaseibacillus casei	IC50	1000000.0	nM	10.1021/jm00159a032
Lacticaseibacillus casei	Lacticaseibacillus casei	IC50	10000000.0	nM	10.1021/jm00349a024
Lacticaseibacillus casei	Lacticaseibacillus casei	ID50	0.01	ug ml-1	10.1021/jm00193a023
Lacticaseibacillus casei	Lacticaseibacillus casei	Inhibition	0.005	%	10.1021/jm00369a024
Lacticaseibacillus casei	Lacticaseibacillus casei	Inhibition	5.0	%	10.1021/jm00369a024
Lacticaseibacillus casei	Lacticaseibacillus casei	Inhibition	nan	%	10.1021/jm00212a010
Lacticaseibacillus casei	Lacticaseibacillus casei	Ratio IC50	0.17	None	10.1021/jm00212a010
Lacticaseibacillus rhamnosus	Lacticaseibacillus rhamnosus	GI50	0.04	nM	10.1021/jm00220a019
Lactobacillus casei	Dihydrofolate reductase	Concentration	1e-08	ng ml-1	10.1021/jm00352a026
Lactobacillus casei	Dihydrofolate reductase	IC50	3.3e-12	ug.mL-1	10.1021/jm00141a010
Lactobacillus casei	Dihydrofolate reductase	IC50	0.0016	ug.mL-1	10.1021/jm00156a029
Lactobacillus casei	Dihydrofolate reductase	IC50	1.3	nM	10.1021/jm00037a012
Lactobacillus casei	Dihydrofolate reductase	IC50	2.2	nM	10.1021/jm950786p
Lactobacillus casei	Dihydrofolate reductase	IC50	3.0	nM	10.1021/jm00193a022
Lactobacillus casei	Dihydrofolate reductase	IC50	3.0	nM	10.1021/jm00220a019
Lactobacillus casei	Dihydrofolate reductase	IC50	4.5	nM	10.1021/jm00228a018
Lactobacillus casei	Dihydrofolate reductase	IC50	5.0	nM	10.1016/j.bmc.2010.05.072
Lactobacillus casei	Dihydrofolate reductase	IC50	6.0	nM	10.1021/jm00019a009
Lactobacillus casei	Dihydrofolate reductase	IC50	6.0	nM	10.1021/jm00034a015
Lactobacillus casei	Dihydrofolate reductase	IC50	6.0	nM	10.1021/jm0701977
Lactobacillus casei	Dihydrofolate reductase	IC50	8.0	nM	10.1021/jm00157a600
Lactobacillus casei	Dihydrofolate reductase	IC50	8.0	nM	10.1021/jm00358a030
Lactobacillus casei	Dihydrofolate reductase	IC50	8.5	nM	10.1021/jm00159a032
Lactobacillus casei	Dihydrofolate reductase	IC50	9.6	nM	10.1021/jm00182a017
Lactobacillus casei	Dihydrofolate reductase	IC50	10.0	nM	10.1021/jm00156a026
Lactobacillus casei	Dihydrofolate reductase	IC50	10.0	nM	10.1021/jm00159a039
Lactobacillus casei	Dihydrofolate reductase	IC50	11.0	nM	10.1021/jm000130i
Lactobacillus casei	Dihydrofolate reductase	IC50	12.0	nM	10.1021/jm00349a024
Lactobacillus casei	Dihydrofolate reductase	IC50	15.0	nM	10.1021/jm00396a029
Lactobacillus casei	Dihydrofolate reductase	IC50	16.0	nM	10.1021/jm00119a018
Lactobacillus casei	Dihydrofolate reductase	IC50	16.0	nM	10.1021/jm00396a022
Lactobacillus casei	Dihydrofolate reductase	IC50	16.0	nM	10.1021/jm00396a029
Lactobacillus casei	Dihydrofolate reductase	IC50	22.0	nM	10.1021/jm0203534
Lactobacillus casei	Dihydrofolate reductase	IC50	22.0	nM	10.1021/jm040123k
Lactobacillus casei	Dihydrofolate reductase	IC50	22.0	nM	10.1021/jm058213s
Lactobacillus casei	Dihydrofolate reductase	IC50	26.0	nM	10.1021/jm00396a029
Lactobacillus casei	Dihydrofolate reductase	IC50	44.0	nM	10.1021/jm000200l
Lactobacillus casei	Dihydrofolate reductase	IC50	55.0	nM	10.1021/jm950786p
Lactobacillus casei	Dihydrofolate reductase	ID50	0.021	uM	10.1021/jm00137a016
Lactobacillus casei	Dihydrofolate reductase	ID50	6.2	nM	10.1021/jm00350a015
Lactobacillus casei	Dihydrofolate reductase	ID50	11.0	nM	10.1021/jm00366a012
Lactobacillus casei	Dihydrofolate reductase	ID50	16.0	nM	10.1021/jm00350a015
Lactobacillus casei	Dihydrofolate reductase	I / E100	1.0	None	10.1021/jm00355a023
Lactobacillus casei	Dihydrofolate reductase	Inhibition	1e-08	%	10.1021/jm00369a024
Lactobacillus casei	Dihydrofolate reductase	Ki	0.004	nM	10.1021/jm00378a025
Lactobacillus casei	Dihydrofolate reductase	pK	7.8	None	10.1021/jm00378a025
Lactobacillus casei	Thymidylate synthase	Concentration	8e-05	ng ml-1	10.1021/jm00352a026
Lactobacillus casei	Thymidylate synthase	IC50	0.0012	ug.mL-1	10.1021/jm00156a029
Lactobacillus casei	Thymidylate synthase	IC50	40000.0	nM	10.1021/jm00182a017
Lactobacillus casei	Thymidylate synthase	IC50	75000.0	nM	10.1021/jm00349a024
Lactobacillus casei	Thymidylate synthase	IC50	86000.0	nM	10.1021/jm00396a022
Lactobacillus casei	Thymidylate synthase	IC50	100000.0	nM	10.1021/jm00159a039
Lactobacillus casei	Thymidylate synthase	IC50	100000.0	nM	10.1021/jm00193a022
Lactobacillus casei	Thymidylate synthase	IC50	100000.0	nM	10.1021/jm00220a019
Lactobacillus casei	Thymidylate synthase	IC50	120000.0	nM	10.1021/jm00119a018
Lactobacillus casei	Thymidylate synthase	IC50	170000.0	nM	10.1021/jm00159a032
Lactobacillus casei	Thymidylate synthase	IC50	190000.0	nM	10.1021/jm00145a012
Lactobacillus casei	Thymidylate synthase	IC50	600000.0	nM	10.1021/jm00157a600
Lactobacillus casei	Thymidylate synthase	IC50	nan	nM	10.1021/jm058213s
Lactobacillus casei	Thymidylate synthase	IC50	nan	None	10.1021/jm000130i
Lactobacillus casei	Thymidylate synthase	IC50	nan	None	10.1021/jm040123k
Lactobacillus casei	Thymidylate synthase	Inhibition	8e-05	%	10.1021/jm00369a024
Leishmania major	Dihydrofolate reductase	Ki	0.1288	nM	10.1021/jm00390a017
Leishmania major	Leishmania major	EC50	1000.0	nM	10.1021/jm00390a017
Leishmania major	Pteridine reductase 1	Ki	39.0	nM	10.1021/jm901059x
Leishmania major	Pteridine reductase 1	Ki	180.0	nM	10.1021/jm300563f
Leishmania mexicana	Glucose transporter	Inhibition	-0.37	%	10.6019/CHEMBL3433997
Leishmania mexicana	Glucose transporter	Inhibition	1.34	%	10.6019/CHEMBL3433997
Leishmania mexicana	Glucose transporter	Inhibition	3.42	%	10.6019/CHEMBL3433997
Mus musculus	B16	ID50	0.1	ug ml-1	10.1021/jm00077a017
Mus musculus	B16-F10	Inhibition	nan	%	10.1016/j.bmc.2012.12.045
Mus musculus	Brain	CL	0.02023	mL.min-1.g-1	10.1124/dmd.112.049254
Mus musculus	Brain	Kel	0.0238	/min	10.1124/dmd.112.049254
Mus musculus	Brain	Ratio	0.05	None	10.1124/dmd.112.049254
Mus musculus	Brain	Vd	0.85	ml	10.1124/dmd.112.049254
Mus musculus	CCRF S-180	ED50	0.016	uM	10.1021/jm00177a025
Mus musculus	CCRF S-180	IC50	5.4	nM	10.1021/jm00358a030
Mus musculus	CCRF S-180	IC50	10.0	nM	10.1021/jm00078a004
Mus musculus	CCRF S-180	Influx Ki	11.4	uM	10.1021/jm00146a008
Mus musculus	Colon 26	IC50	40000.0	nM	10.1021/jm00037a012
Mus musculus	Dihydrofolate reductase	IC50	6.6	nM	10.1021/jm00037a012
Mus musculus	Dihydrofolate reductase	IC50	20.0	nM	10.1021/jm00159a023
Mus musculus	Dihydrofolate reductase	IC50	25.0	nM	10.1021/jm00106a016
Mus musculus	Dihydrofolate reductase	IC50	25.0	nM	10.1021/jm00391a031
Mus musculus	Dihydrofolate reductase	IC50	25.0	nM	10.1021/jm00402a013
Mus musculus	Dihydrofolate reductase	IC50	25.0	nM	10.1021/jm00402a014
Mus musculus	Dihydrofolate reductase	IC50	35.0	nM	10.1021/jm00155a012
Mus musculus	Dihydrofolate reductase	IC50	35.0	nM	10.1021/jm00160a014
Mus musculus	Dihydrofolate reductase	IC50	45.0	nM	10.1021/jm00380a011
Mus musculus	Dihydrofolate reductase	IC50	50.0	nM	10.1021/jm00373a014
Mus musculus	Dihydrofolate reductase	IC50	73.0	nM	10.1021/jm960250j
Mus musculus	Dihydrofolate reductase	IC50/[E]	0.5	None	10.1021/jm00159a023
Mus musculus	Dihydrofolate reductase	IC50/[E]	0.5	None	10.1021/jm00160a014
Mus musculus	Dihydrofolate reductase	ID50	0.0068	uM	10.1021/jm00137a016
Mus musculus	Dihydrofolate reductase	ID50	0.05	uM	10.1021/jm00371a008
Mus musculus	Dihydrofolate reductase	ID50	2.0	nM	10.1021/jm00366a012
Mus musculus	Dihydrofolate reductase	ID50	2.7	nM	10.1021/jm00350a015
Mus musculus	Dihydrofolate reductase	ID50	9.0	nM	10.1021/jm00366a012
Mus musculus	Dihydrofolate reductase	ID50	32.0	nM	10.1021/jm00366a012
Mus musculus	Dihydrofolate reductase	Ki	5.62e-09	nM	10.1021/jm00401a023
Mus musculus	Dihydrofolate reductase	Ki	0.003	nM	10.1016/j.bmc.2009.08.044
Mus musculus	Dihydrofolate reductase	Ki	0.0032	nM	10.1021/jm00352a026
Mus musculus	Dihydrofolate reductase	Ki	0.0043	nM	10.1021/jm00344a018
Mus musculus	Dihydrofolate reductase	Ki	0.00442	nM	10.1021/jm00156a026
Mus musculus	Dihydrofolate reductase	Ki	0.00482	nM	10.1021/jm00078a004
Mus musculus	Dihydrofolate reductase	Ki	0.00482	nM	10.1021/jm00094a011
Mus musculus	Dihydrofolate reductase	Ki	0.00528	nM	10.1021/jm00080a019
Mus musculus	Dihydrofolate reductase	Ki	0.00545	nM	10.1021/jm00119a018
Mus musculus	Dihydrofolate reductase	Ki	0.00548	nM	10.1021/jm00156a029
Mus musculus	Dihydrofolate reductase	Ki	0.0056	nM	10.1021/jm00163a035
Mus musculus	Dihydrofolate reductase	Ki	0.00575	nM	10.1021/jm00067a020
Mus musculus	Dihydrofolate reductase	Ki	0.00581	nM	10.1021/jm00146a008
Mus musculus	Dihydrofolate reductase	Ki	0.006	nM	10.1021/jm00080a017
Mus musculus	Dihydrofolate reductase	Ki	0.006	nM	10.1021/jm00146a008
Mus musculus	Dihydrofolate reductase	Ki	0.006	nM	10.1021/jm00164a033
Mus musculus	Dihydrofolate reductase	Ki	0.006	nM	10.1021/jm00349a024
Mus musculus	Dihydrofolate reductase	Ki	3900.0	nM	10.1021/jm00163a035
Mus musculus	Dihydrofolate reductase	Log 1/C	2.93	None	10.1021/jm00369a019
Mus musculus	Dihydrofolate reductase	Log 1/C	8.73	None	10.1021/jm00369a019
Mus musculus	Dihydrofolate reductase	Relative activity	1.0	None	10.1021/jm00373a014
Mus musculus	Ehrlich	IC50	12.6	nM	10.1021/jm00358a030
Mus musculus	Ehrlich	Influx Ki	10.1	uM	10.1021/jm00146a008
Mus musculus	Ehrlich	Ki	10100.0	nM	10.1021/jm00141a010
Mus musculus	Ehrlich	Km	10100.0	nM	10.1021/jm00349a024
Mus musculus	EL4	IC50	1570.0	nM	10.1021/jm970085n
Mus musculus	EL4	IC50	5100.0	nM	10.1021/np500836y
Mus musculus	Folylpoly-gamma-glutamate synthetase	Concentration	47.0	uM	10.1021/jm00376a005
Mus musculus	Folylpoly-gamma-glutamate synthetase	FPGS activity	2.64	nM hr-1 mg-1	10.1021/jm9605288
Mus musculus	Folylpoly-gamma-glutamate synthetase	Ki	166000.0	nM	10.1021/jm00155a012
Mus musculus	Folylpoly-gamma-glutamate synthetase	Km	165000.0	nM	10.1021/jm00123a037
Mus musculus	Folylpoly-gamma-glutamate synthetase	Reaction rate	1.71	nM hr-1	10.1021/jm00376a005
Mus musculus	Folylpoly-gamma-glutamate synthetase	Specific activity	0.38	pM hr-1 (mg of protein)-1	10.1021/jm00078a004
Mus musculus	GAR transformylase	IC50	20000.0	nM	10.1021/jm00119a018
Mus musculus	L1210	EC50	3.2	nM	10.1021/jm00362a019
Mus musculus	L1210	ED50	0.016	uM	10.1021/jm00177a025
Mus musculus	L1210	Effllux	0.23	min-1	10.1021/jm00146a008
Mus musculus	L1210	Efflux Ki	0.203	min-1	10.1021/jm00146a008
Mus musculus	L1210	IC50	0.005	nM	10.1021/jm00391a031
Mus musculus	L1210	IC50	0.84	nM	10.1021/jm00358a030
Mus musculus	L1210	IC50	2.0	nM	10.1021/jm00155a012
Mus musculus	L1210	IC50	2.0	nM	10.1021/jm00159a023
Mus musculus	L1210	IC50	2.0	nM	10.1021/jm50001a021
Mus musculus	L1210	IC50	2.1	nM	10.1021/jm00119a018
Mus musculus	L1210	IC50	2.5	nM	10.1021/jm00159a039
Mus musculus	L1210	IC50	2.55	nM	10.1021/jm00156a029
Mus musculus	L1210	IC50	2.7	nM	10.1021/jm00141a010
Mus musculus	L1210	IC50	2.7	nM	10.1021/jm00146a008
Mus musculus	L1210	IC50	2.7	nM	10.1021/jm00349a024
Mus musculus	L1210	IC50	3.28	nM	10.1021/jm00146a008
Mus musculus	L1210	IC50	3.4	nM	10.1021/jm00094a011
Mus musculus	L1210	IC50	3.9	nM	10.1021/jm00080a017
Mus musculus	L1210	IC50	3.9	nM	10.1021/jm00396a022
Mus musculus	L1210	IC50	3.92	nM	10.1021/jm00164a033
Mus musculus	L1210	IC50	4.4	nM	10.1021/jm00124a019
Mus musculus	L1210	IC50	4.5	nM	10.1021/jm00401a023
Mus musculus	L1210	IC50	4.51	nM	10.1021/jm00080a019
Mus musculus	L1210	IC50	4.6	nM	10.1021/jm00105a031
Mus musculus	L1210	IC50	4.6	nM	10.1021/jm00106a016
Mus musculus	L1210	IC50	4.6	nM	10.1021/jm00402a013
Mus musculus	L1210	IC50	4.6	nM	10.1021/jm00402a014
Mus musculus	L1210	IC50	5.0	nM	10.1021/jm00163a035
Mus musculus	L1210	IC50	5.0	nM	10.1021/jm00399a013
Mus musculus	L1210	IC50	7.0	nM	10.1021/jm960250j
Mus musculus	L1210	IC50	9.0	nM	10.1021/jm00078a004
Mus musculus	L1210	IC50	9.0	nM	10.1021/jm00105a036
Mus musculus	L1210	IC50	9.0	nM	10.1021/jm00123a001
Mus musculus	L1210	IC50	9.5	nM	10.1021/jm00067a020
Mus musculus	L1210	IC50	10.0	nM	10.1021/jm00145a012
Mus musculus	L1210	IC50	12.0	nM	10.1021/jm00380a011
Mus musculus	L1210	IC50	20.0	nM	10.1021/jm9505526
Mus musculus	L1210	IC50	20.0	nM	10.1021/jm950553y
Mus musculus	L1210	IC50	24.0	nM	10.1021/jm00373a014
Mus musculus	L1210	IC50	30.0	nM	10.1021/jm00159a023
Mus musculus	L1210	IC50	200.0	nM	10.1021/jm00160a014
Mus musculus	L1210	IC50	200.0	nM	10.1021/jm00391a031
Mus musculus	L1210	IC50	1000.0	nM	10.1021/jm00380a011
Mus musculus	L1210	IC50	1300.0	nM	10.1021/jm960250j
Mus musculus	L1210	IC50	19000.0	nM	10.1021/jm50001a021
Mus musculus	L1210	IC50	60000.0	nM	10.1021/jm00159a032
Mus musculus	L1210	IC50	186000.0	nM	10.1021/jm00124a019
Mus musculus	L1210	IC50	200000.0	nM	10.1021/jm00105a031
Mus musculus	L1210	IC50	220000.0	nM	10.1021/jm00159a023
Mus musculus	L1210	IC50	220000.0	nM	10.1021/jm50001a021
Mus musculus	L1210	ID50	0.01	uM	10.1021/jm00137a016
Mus musculus	L1210	ID50	0.01	uM	10.1021/jm00144a016
Mus musculus	L1210	ID50	0.012	uM	10.1021/jm00371a008
Mus musculus	L1210	ID50	0.04	uM	10.1021/jm00083a017
Mus musculus	L1210	ID50	20.0	nM	10.1021/jm00366a012
Mus musculus	L1210	ILS	48.0	%	10.1021/jm00344a018
Mus musculus	L1210	ILS	70.0	%	10.1021/jm00220a019
Mus musculus	L1210	ILS	72.0	%	10.1021/jm00137a016
Mus musculus	L1210	ILS	72.0	%	10.1021/jm00193a021
Mus musculus	L1210	ILS	77.0	%	10.1021/jm00364a017
Mus musculus	L1210	ILS	83.0	%	10.1021/jm00137a016
Mus musculus	L1210	ILS	85.0	%	10.1021/jm00145a012
Mus musculus	L1210	ILS	88.0	%	10.1021/jm00193a022
Mus musculus	L1210	ILS	88.0	%	10.1021/jm00364a017
Mus musculus	L1210	ILS	95.0	%	10.1021/jm00402a014
Mus musculus	L1210	ILS	100.0	%	10.1021/jm00137a016
Mus musculus	L1210	ILS	100.0	%	10.1021/jm00364a017
Mus musculus	L1210	ILS	139.0	%	10.1021/jm00352a026
Mus musculus	L1210	ILS	151.0	%	10.1021/jm00352a026
Mus musculus	L1210	ILS	152.0	%	10.1021/jm00349a024
Mus musculus	L1210	ILS	173.0	%	10.1021/jm00146a008
Mus musculus	L1210	Increased life span	122.0	%	10.1021/jm00380a011
Mus musculus	L1210	Increased life span	135.0	%	10.1021/jm00380a011
Mus musculus	L1210	Influx Ki	3.7	uM	10.1021/jm00146a008
Mus musculus	L1210	Influx Ki	4.57	uM	10.1021/jm00146a008
Mus musculus	L1210	Inhibition	95.0	%	10.1021/jm00159a032
Mus musculus	L1210	Inhibition	98.0	%	10.1021/jm00159a032
Mus musculus	L1210	k	0.21	min-1	10.1021/jm00080a019
Mus musculus	L1210	k	0.213	min-1	10.1021/jm00156a026
Mus musculus	L1210	k	0.22	min-1	10.1021/jm00119a018
Mus musculus	L1210	k	0.23	M-1 min-1	10.1021/jm00344a018
Mus musculus	L1210	k	0.23	min-1	10.1021/jm00349a024
Mus musculus	L1210	K	0.33	min-1	10.1021/jm00156a029
Mus musculus	L1210	Ki	0.0032	nM	10.1021/jm00159a039
Mus musculus	L1210	Ki	3500.0	nM	10.1021/jm00344a018
Mus musculus	L1210	Ki	3650.0	nM	10.1021/jm00141a010
Mus musculus	L1210	Ki	3930.0	nM	10.1021/jm00078a004
Mus musculus	L1210	Ki	5610.0	nM	10.1021/jm00156a026
Mus musculus	L1210	Km	3300.0	nM	10.1021/jm00156a029
Mus musculus	L1210	Km	3300.0	nM	10.1021/jm00344a018
Mus musculus	L1210	Km	3510.0	nM	10.1021/jm00094a011
Mus musculus	L1210	Km	3700.0	nM	10.1021/jm00349a024
Mus musculus	L1210	Km	3950.0	nM	10.1021/jm00119a018
Mus musculus	L1210	Km	4860.0	nM	10.1021/jm00080a019
Mus musculus	L1210	Log CR	2.55	None	10.1021/jm00169a014
Mus musculus	L1210	Mean survival time	16.4	day	10.1021/jm00380a011
Mus musculus	L1210	Mean survival time	17.4	day	10.1021/jm00380a011
Mus musculus	L1210	MIC50	2.48	nM	10.1021/jm00156a026
Mus musculus	L1210	MIC50	2.71	nM	10.1021/jm00352a026
Mus musculus	L1210	MST	15.8	day	10.1021/jm00352a026
Mus musculus	L1210	MST	16.6	day	10.1021/jm00352a026
Mus musculus	L1210	MST	17.1	day	10.1021/jm00349a024
Mus musculus	L1210	MTX equivalent	nan	None	10.1021/jm00137a016
Mus musculus	L1210	Range	22.0	None	10.1021/jm00364a017
Mus musculus	L1210	Range	23.0	day	10.1021/jm00402a014
Mus musculus	L1210	Range	23.0	None	10.1021/jm00364a017
Mus musculus	L1210	Range	28.0	None	10.1021/jm00364a017
Mus musculus	L1210	Rate	56.3	pM min-1 (g dry weight)-1	10.1021/jm00156a029
Mus musculus	L1210	Relative activity	1.0	None	10.1021/jm00373a014
Mus musculus	L1210	Survival	17.2	day	10.1021/jm00402a014
Mus musculus	L1210	Survival	48.0	%	10.1021/jm00221a008
Mus musculus	L1210	Survival	61.0	%	10.1021/jm00221a008
Mus musculus	L1210	Survival	68.0	%	10.1021/jm00221a008
Mus musculus	L1210	Survival	81.0	%	10.1021/jm00221a008
Mus musculus	L1210	T/C	9.0	None	10.1021/jm00364a017
Mus musculus	L1210	T/C	175.0	%	10.1021/jm00106a016
Mus musculus	L1210	T/C	188.0	%	10.1021/jm00106a016
Mus musculus	L1210	T/C	200.0	%	10.1021/jm00106a016
Mus musculus	L1210	T/C	213.0	%	10.1021/jm00106a016
Mus musculus	L1210	Weight at term	19.8	g	10.1021/jm00349a024
Mus musculus	L1210	Weight change	8.0	%	10.1021/jm00402a014
Mus musculus	L1210 ( R81)	IC50	197000.0	nM	10.1021/jm00402a014
Mus musculus	L1210 ( R81)	IC50	200000.0	nM	10.1021/jm00402a013
Mus musculus	L1210 ( R81)	IC50	205000.0	nM	10.1021/jm00380a011
Mus musculus	L1210 ( R81)	IC50	220000.0	nM	10.1021/jm00155a012
Mus musculus	L5178Y	Log 1/C	2.9	None	10.1021/jm00344a013
Mus musculus	L5178Y	Log 1/C	8.89	None	10.1021/jm00344a012
Mus musculus	Liver	Drug metabolism	nan	None	10.1021/jm00217a012
Mus musculus	MC-38	IC50	66.0	nM	10.1021/jm00037a012
Mus musculus	MEF	IC50	120.0	nM	10.1016/j.bmcl.2007.03.012
Mus musculus	Mus musculus	30 days survivors	0.0	None	10.1021/jm00156a026
Mus musculus	Mus musculus	7-day weight change	-9.0	%	10.1021/jm00373a014
Mus musculus	Mus musculus	7-day weight change	0.0	%	10.1021/jm00373a014
Mus musculus	Mus musculus	Activity	0.17	mm	10.1016/j.bmcl.2008.10.116
Mus musculus	Mus musculus	Activity	0.46	mm	10.1016/j.bmcl.2008.10.116
Mus musculus	Mus musculus	Activity	15.0	mg kg-1	10.1021/jm00220a019
Mus musculus	Mus musculus	Activity	16.8	None	10.1021/jm051029m
Mus musculus	Mus musculus	Activity	21.4	g	10.1016/j.ejmech.2016.11.010
Mus musculus	Mus musculus	Activity	21.62	g	10.1016/j.ejmech.2016.11.010
Mus musculus	Mus musculus	Activity	21.85	g	10.1016/j.ejmech.2016.11.010
Mus musculus	Mus musculus	Activity	23.98	g	10.1016/j.ejmech.2016.11.010
Mus musculus	Mus musculus	Activity	24.88	g	10.1016/j.ejmech.2016.11.010
Mus musculus	Mus musculus	Activity	25.28	g	10.1016/j.ejmech.2016.11.010
Mus musculus	Mus musculus	Activity	25.47	g	10.1016/j.ejmech.2016.11.010
Mus musculus	Mus musculus	Activity	60.0	%	10.1021/acs.jmedchem.9b00794
Mus musculus	Mus musculus	Activity	63.0	%	10.1016/j.bmcl.2016.07.047
Mus musculus	Mus musculus	Activity	78.0	%	10.1021/jm00371a008
Mus musculus	Mus musculus	Activity	83.0	%	10.1016/j.bmcl.2016.07.047
Mus musculus	Mus musculus	Activity	100.0	%	10.1021/jm00371a008
Mus musculus	Mus musculus	Activity	133.0	%	10.1021/jm00371a008
Mus musculus	Mus musculus	Activity	nan	None	10.1016/j.bmc.2015.03.043
Mus musculus	Mus musculus	Activity	nan	None	10.1016/j.ejmech.2018.07.045
Mus musculus	Mus musculus	Activity	nan	None	10.1021/acs.jmedchem.7b01046
Mus musculus	Mus musculus	Activity	nan	None	10.1021/acs.jmedchem.7b01775
Mus musculus	Mus musculus	Activity	nan	None	10.1021/acs.jmedchem.9b00794
Mus musculus	Mus musculus	Animals	0.0	%	10.1021/jm9505526
Mus musculus	Mus musculus	Animals	0.0	%	10.1021/jm950553y
Mus musculus	Mus musculus	Animals	12.0	%	10.1021/jm9505526
Mus musculus	Mus musculus	Animals	12.0	%	10.1021/jm950553y
Mus musculus	Mus musculus	Animals	14.0	%	10.1021/jm9505526
Mus musculus	Mus musculus	Animals	25.0	%	10.1021/jm9505526
Mus musculus	Mus musculus	Animals	25.0	%	10.1021/jm950553y
Mus musculus	Mus musculus	Average tumor volume	4.0	mm**3	10.1021/jm00067a020
Mus musculus	Mus musculus	Average tumor volume	19.0	mm**3	10.1021/jm00067a020
Mus musculus	Mus musculus	Average tumor volume	34.0	mm**3	10.1021/jm00067a020
Mus musculus	Mus musculus	Average tumor volume	113.0	mm**3	10.1021/jm00067a020
Mus musculus	Mus musculus	Average tumor volume	187.0	mm**3	10.1021/jm00067a020
Mus musculus	Mus musculus	Average tumor volume	310.0	mm**3	10.1021/jm00067a020
Mus musculus	Mus musculus	Average tumor volume	382.0	mm**3	10.1021/jm00067a020
Mus musculus	Mus musculus	Average tumor volume	1260.0	mm**3	10.1021/jm00067a020
Mus musculus	Mus musculus	Average weight	23.1	None	10.1021/jm00364a017
Mus musculus	Mus musculus	Average weight	23.9	None	10.1021/jm00364a017
Mus musculus	Mus musculus	Average weight	24.6	None	10.1021/jm00364a017
Mus musculus	Mus musculus	AWC	-0.4	g	10.1021/jm00080a019
Mus musculus	Mus musculus	AWC	0.8	g	10.1021/jm00080a019
Mus musculus	Mus musculus	BEI	13.7	%	10.1124/dmd.112.049254
Mus musculus	Mus musculus	BEI	21.4	%	10.1124/dmd.112.049254
Mus musculus	Mus musculus	BEI	24.2	%	10.1124/dmd.112.049254
Mus musculus	Mus musculus	BEI	37.9	%	10.1124/dmd.112.049254
Mus musculus	Mus musculus	BEI	46.4	%	10.1124/dmd.112.049254
Mus musculus	Mus musculus	BEI	57.2	%	10.1124/dmd.112.049254
Mus musculus	Mus musculus	BEI	63.8	%	10.1124/dmd.112.049254
Mus musculus	Mus musculus	BEI	72.7	%	10.1124/dmd.112.049254
Mus musculus	Mus musculus	BEI	90.0	%	10.1124/dmd.112.049254
Mus musculus	Mus musculus	Deaths/total	0.0	None	10.1021/jm00080a019
Mus musculus	Mus musculus	FC	2.0	None	10.1016/j.bmc.2015.03.043
Mus musculus	Mus musculus	FC	2.1	None	10.1016/j.bmc.2015.03.043
Mus musculus	Mus musculus	FC	2.8	None	10.1016/j.bmc.2015.03.043
Mus musculus	Mus musculus	IC50	3.28	nM	10.1021/jm00146a008
Mus musculus	Mus musculus	IC50	31.0	nM	10.1021/jm00037a012
Mus musculus	Mus musculus	ILS	46.0	%	10.1021/jm00156a026
Mus musculus	Mus musculus	ILS	63.0	%	10.1021/jm00366a012
Mus musculus	Mus musculus	ILS	78.0	%	10.1021/jm00366a012
Mus musculus	Mus musculus	ILS	89.0	%	10.1021/jm00366a012
Mus musculus	Mus musculus	ILS	100.0	%	10.1021/jm00366a012
Mus musculus	Mus musculus	ILS	100.0	%	10.1021/jm00373a014
Mus musculus	Mus musculus	ILS	111.0	%	10.1021/jm00373a014
Mus musculus	Mus musculus	ILS	119.0	%	10.1021/jm00156a026
Mus musculus	Mus musculus	ILS	122.0	%	10.1021/jm00366a012
Mus musculus	Mus musculus	ILS	133.0	%	10.1021/jm00366a012
Mus musculus	Mus musculus	ILS	137.0	%	10.1021/jm00156a026
Mus musculus	Mus musculus	ILS	147.0	%	10.1021/jm00156a026
Mus musculus	Mus musculus	ILS	152.0	%	10.1021/jm00146a008
Mus musculus	Mus musculus	ILS	187.0	%	10.1021/jm00369a024
Mus musculus	Mus musculus	Inhibition	38.0	%	10.1016/j.bmc.2015.03.043
Mus musculus	Mus musculus	Inhibition	49.0	%	10.1016/j.bmc.2015.03.043
Mus musculus	Mus musculus	Inhibition	66.0	%	10.1016/j.bmc.2015.03.043
Mus musculus	Mus musculus	Inhibition	76.0	%	10.1016/j.bmc.2015.03.043
Mus musculus	Mus musculus	Inhibition	nan	%	10.1021/jm500192s
Mus musculus	Mus musculus	Kd	220.0	None	10.1021/jm950793d
Mus musculus	Mus musculus	Kd	nan	None	10.1021/jm950793d
Mus musculus	Mus musculus	Ki	0.004	None	10.1021/jm950793d
Mus musculus	Mus musculus	Ki	0.13	None	10.1021/jm950793d
Mus musculus	Mus musculus	Ki	4200.0	nM	10.1021/jm00067a020
Mus musculus	Mus musculus	Km	339000.0	nM	10.1021/jm00349a024
Mus musculus	Mus musculus	LD10	15.0	mg kg-1	10.1021/jm00369a024
Mus musculus	Mus musculus	Log2	4.0	None	10.1021/jm970085n
Mus musculus	Mus musculus	Log2	4.2	None	10.1021/jm970085n
Mus musculus	Mus musculus	Log2	5.4	None	10.1021/jm970085n
Mus musculus	Mus musculus	Median T/C	15.5	day	10.1021/jm00137a016
Mus musculus	Mus musculus	Median T/C	16.5	day	10.1021/jm00137a016
Mus musculus	Mus musculus	Median T/C	18.0	day	10.1021/jm00137a016
Mus musculus	Mus musculus	MST	9.6	day	10.1021/jm00156a026
Mus musculus	Mus musculus	MST	14.5	day	10.1021/jm00156a026
Mus musculus	Mus musculus	MST	15.7	day	10.1021/jm00156a026
Mus musculus	Mus musculus	MST	16.3	day	10.1021/jm00156a026
Mus musculus	Mus musculus	MST	17.1	day	10.1021/jm00146a008
Mus musculus	Mus musculus	MST	20.4	day	10.1021/jm00369a024
Mus musculus	Mus musculus	MTD	17.5	mg kg-1	10.1021/jm00195a002
Mus musculus	Mus musculus	MTD	108.0	mg kg-1	10.1021/jm00195a002
Mus musculus	Mus musculus	Paw swelling	2.14	mM	10.1021/jm9505526
Mus musculus	Mus musculus	Paw swelling	2.14	mM	10.1021/jm950553y
Mus musculus	Mus musculus	Paw swelling	2.16	mM	10.1021/jm9505526
Mus musculus	Mus musculus	Paw swelling	2.16	mM	10.1021/jm950553y
Mus musculus	Mus musculus	Paw swelling	2.18	mM	10.1021/jm9505526
Mus musculus	Mus musculus	Paw swelling	2.18	mM	10.1021/jm950553y
Mus musculus	Mus musculus	Paw swelling	2.22	mM	10.1021/jm9505526
Mus musculus	Mus musculus	Paw swelling	2.24	mM	10.1021/jm9505526
Mus musculus	Mus musculus	Paw swelling	2.24	mM	10.1021/jm950553y
Mus musculus	Mus musculus	Paw swelling	2.26	mM	10.1021/jm9505526
Mus musculus	Mus musculus	Paw swelling	2.27	mM	10.1021/jm9505526
Mus musculus	Mus musculus	Paw swelling	2.28	mM	10.1021/jm9505526
Mus musculus	Mus musculus	Plasma level	6.0	mg ml-1	10.1021/jm00349a024
Mus musculus	Mus musculus	Plasma level	9.0	mg ml-1	10.1021/jm00349a024
Mus musculus	Mus musculus	Plasma level	19.0	mg ml-1	10.1021/jm00349a024
Mus musculus	Mus musculus	Plasma level	31.0	mg ml-1	10.1021/jm00349a024
Mus musculus	Mus musculus	Plasma level	93.0	mg ml-1	10.1021/jm00349a024
Mus musculus	Mus musculus	Plasma level	820.0	mg ml-1	10.1021/jm00349a024
Mus musculus	Mus musculus	Plasma level	7600.0	mg ml-1	10.1021/jm00349a024
Mus musculus	Mus musculus	Suppressive dose	0.625	mg kg-1	10.1021/jm970085n
Mus musculus	Mus musculus	Survival days	3.0	None	10.1021/jm00371a008
Mus musculus	Mus musculus	Survival days	15.0	None	10.1021/jm00371a008
Mus musculus	Mus musculus	Survival days	16.0	None	10.1021/jm00371a008
Mus musculus	Mus musculus	Survival days	18.0	None	10.1021/jm00371a008
Mus musculus	Mus musculus	Survival days	21.0	None	10.1021/jm00371a008
Mus musculus	Mus musculus	Survival range	20.0	None	10.1021/jm00373a014
Mus musculus	Mus musculus	Survival range	22.0	None	10.1021/jm00373a014
Mus musculus	Mus musculus	Survivors	0.0	None	10.1021/jm00145a012
Mus musculus	Mus musculus	Survivors	5.0	None	10.1021/jm970055k
Mus musculus	Mus musculus	Survivors	nan	None	10.1021/jm00131a009
Mus musculus	Mus musculus	T1/2	0.48	hr	10.1124/dmd.112.049254
Mus musculus	Mus musculus	T/C	0.74	None	10.1021/jm00080a019
Mus musculus	Mus musculus	T/C	0.79	None	10.1021/jm00080a019
Mus musculus	Mus musculus	T/C	2.0	%	10.1021/jm00067a020
Mus musculus	Mus musculus	T/C	3.0	%	10.1021/jm00067a020
Mus musculus	Mus musculus	T/C	13.0	None	10.1021/jm00366a012
Mus musculus	Mus musculus	T/C	15.0	%	10.1021/jm00067a020
Mus musculus	Mus musculus	T/C	16.0	None	10.1021/jm00366a012
Mus musculus	Mus musculus	T/C	17.0	None	10.1021/jm00366a012
Mus musculus	Mus musculus	T/C	18.0	%	10.1021/jm00067a020
Mus musculus	Mus musculus	T/C	18.0	None	10.1021/jm00373a014
Mus musculus	Mus musculus	T/C	19.0	None	10.1021/jm00373a014
Mus musculus	Mus musculus	T/C	20.0	None	10.1021/jm00366a012
Mus musculus	Mus musculus	T/C	21.0	None	10.1021/jm00366a012
Mus musculus	Mus musculus	T/C	26.0	%	10.1021/jm00067a020
Mus musculus	Mus musculus	T/C	30.0	%	10.1021/jm00078a004
Mus musculus	Mus musculus	T/C	31.0	%	10.1021/jm00037a012
Mus musculus	Mus musculus	T/C	31.0	%	10.1021/jm00078a004
Mus musculus	Mus musculus	T/C	35.0	%	10.1021/jm00037a012
Mus musculus	Mus musculus	T/C	49.0	%	10.1021/jm00078a004
Mus musculus	Mus musculus	T/C	53.0	%	10.1021/jm00037a012
Mus musculus	Mus musculus	T/C	61.0	%	10.1021/jm00067a020
Mus musculus	Mus musculus	T/C	65.0	%	10.1021/jm00037a012
Mus musculus	Mus musculus	T/C	71.0	%	10.1021/jm00037a012
Mus musculus	Mus musculus	T/C	81.0	%	10.1021/jm00078a004
Mus musculus	Mus musculus	T/C	83.0	%	10.1021/jm00078a004
Mus musculus	Mus musculus	T/C	86.0	%	10.1021/jm00067a020
Mus musculus	Mus musculus	T/C	92.0	%	10.1021/jm00131a009
Mus musculus	Mus musculus	T/C	92.0	%	10.1021/jm970055k
Mus musculus	Mus musculus	T/C	100.0	%	10.1021/jm00037a012
Mus musculus	Mus musculus	T/C	100.0	%	10.1021/jm00078a004
Mus musculus	Mus musculus	T/C	122.0	%	10.1021/jm00037a012
Mus musculus	Mus musculus	T/C	137.0	%	10.1021/jm00037a012
Mus musculus	Mus musculus	T/C	149.0	%	10.1021/jm00037a012
Mus musculus	Mus musculus	T/C	168.0	%	10.1021/jm00037a012
Mus musculus	Mus musculus	T/C	172.0	%	10.1021/jm00037a012
Mus musculus	Mus musculus	TGD	5.0	day	10.1021/jm9606453
Mus musculus	Mus musculus	TIME	288.0	hr	10.1021/jm9606453
Mus musculus	Mus musculus	Toxic deaths	0.0	None	10.1021/jm00080a019
Mus musculus	Mus musculus	Toxic deaths	0.0	None	10.1021/jm00156a026
Mus musculus	Mus musculus	Toxic deaths	1.0	None	10.1021/jm00156a026
Mus musculus	Mus musculus	Toxic deaths	6.0	None	10.1021/jm00156a026
Mus musculus	Mus musculus	Toxic deaths	10.0	None	10.1021/jm00156a026
Mus musculus	Mus musculus	Tumor free/total	0.0	None	10.1021/jm00080a019
Mus musculus	Mus musculus	Tumor size	1.6	mM	10.1021/jm9606453
Mus musculus	Mus musculus	Tumor size	7.3	mM	10.1021/jm9606453
Mus musculus	Mus musculus	Tumor volume	108.0	mm**3	10.1021/jm00078a004
Mus musculus	Mus musculus	Tumor volume	180.0	mm**3	10.1021/jm00078a004
Mus musculus	Mus musculus	Tumor volume	187.0	mm**3	10.1021/jm00078a004
Mus musculus	Mus musculus	Tumor volume	347.0	mm**3	10.1021/jm00131a009
Mus musculus	Mus musculus	Tumor volume	389.0	mm**3	10.1021/jm00131a009
Mus musculus	Mus musculus	Tumor volume	411.0	mm**3	10.1021/jm00131a009
Mus musculus	Mus musculus	Tumor volume	540.0	mm**3	10.1021/jm00078a004
Mus musculus	Mus musculus	Tumor volume	624.0	mm**3	10.1021/jm00078a004
Mus musculus	Mus musculus	Tumor volume	987.0	mm**3	10.1021/jm00131a009
Mus musculus	Mus musculus	Tumor volume	1437.0	mm**3	10.1021/jm00078a004
Mus musculus	Mus musculus	Tumor volume	1914.0	mm**3	10.1021/jm00131a009
Mus musculus	Mus musculus	Tumor volume	2270.0	mm**3	10.1021/jm00131a009
Mus musculus	Mus musculus	Tumor volume	nan	None	10.1021/jm00131a009
Mus musculus	Mus musculus	WEIGHT	19.8	g	10.1021/jm00146a008
Mus musculus	Mus musculus	Weight change	-8.0	%	10.1021/jm00371a008
Mus musculus	Mus musculus	Weight change	-5.0	%	10.1021/jm00371a008
Mus musculus	Mus musculus	Weight change	-2.0	g mouse-1	10.1021/jm00366a012
Mus musculus	Mus musculus	Weight change	-1.0	%	10.1021/jm00371a008
Mus musculus	Mus musculus	Weight change	0.6	None	10.1021/jm00364a017
Mus musculus	Mus musculus	Weight change	1.0	g mouse-1	10.1021/jm00366a012
Mus musculus	Mus musculus	Weight change	1.3	None	10.1021/jm00364a017
Mus musculus	Mus musculus	Weight change	2.1	None	10.1021/jm00364a017
Mus musculus	Mus musculus	Weight change	3.0	g mouse-1	10.1021/jm00366a012
Mus musculus	Mus musculus	Weight change	3.9	None	10.1021/jm00131a009
Mus musculus	Mus musculus	Weight change	6.0	g mouse-1	10.1021/jm00366a012
Mus musculus	Mus musculus	Weight change	8.0	g mouse-1	10.1021/jm00366a012
Mus musculus	Mus musculus	Weight change	11.0	g mouse-1	10.1021/jm00366a012
Mus musculus	NIH3T3	IC50	0.24	ug.mL-1	10.1007/s00044-013-0773-3
Mus musculus	Nitric oxide synthase, inducible	IC50	nan	None	None
Mus musculus	Nitric oxide synthase, inducible	Ki	nan	None	None
Mus musculus	P388	Activity	56.0	mg kg-1	10.1021/jm00195a002
Mus musculus	P388	Activity	102.0	mg kg-1	10.1021/jm00195a002
Mus musculus	P388	Activity	nan	None	10.1021/np50063a010
Mus musculus	P388	GI50	25.0	nM	None
Mus musculus	P388	IC50	0.002	ug.mL-1	10.1021/np990140q
Mus musculus	P388	IC50	4.8	nM	10.1021/jm9505122
Mus musculus	P388	IC50	23.0	nM	10.1021/jm00037a012
Mus musculus	P388	IC50	66.0	nM	10.1021/np50063a010
Mus musculus	P388	IC50	223.0	nM	10.1021/jm00037a012
Mus musculus	P388	IZ	27.5	mm	10.1021/np50063a010
Mus musculus	P388	IZ	40.0	mm	10.1021/np50063a010
Mus musculus	P388	MED	1.5	mg kg-1	10.1021/jm00195a002
Mus musculus	P388	MED	27.9	mg kg-1	10.1021/jm00195a002
Mus musculus	P388	Survival time	19.7	day	10.1021/jm00156a029
Mus musculus	P388	Survival time	20.3	day	10.1021/jm00156a029
Mus musculus	P388	T/C	118.0	%	10.1021/jm00156a029
Mus musculus	P388	T/C	182.0	%	10.1021/jm00156a029
Mus musculus	P388/ADR	GI50	25.0	nM	None
Mus musculus	Plasma	Drug metabolism	nan	None	10.1021/jm00217a012
Mus musculus	R1	EC50	680.0	nM	10.1021/jm040144e
Mus musculus	R1	EC50	720.0	nM	10.1021/jm00034a015
Mus musculus	R1	EC50	1050.0	nM	10.1021/jm010575m
Mus musculus	RAW264.7	IC50	5020.0	nM	10.1016/j.ejmech.2019.06.036
Mus musculus	RAW264.7	IC50	159200.0	nM	10.1016/j.ejmech.2019.06.036
Mus musculus	RAW264.7	Ratio IC50	31.9	None	10.1016/j.ejmech.2019.06.036
Mus musculus	SCC-7	IC50	5.8	nM	10.1021/jm00040a008
Mus musculus	ScN2a	EC50	nan	None	10.1021/jm061045z
Mus musculus	ScN2a	LD50	nan	None	10.1021/jm061045z
Mus musculus	Solute carrier family 22 member 20	Ki	597000.0	nM	10.1074/jbc.m703467200
Mus musculus	Solute carrier family 22 member 20	Ki	602559.59	nM	10.1074/jbc.m703467200
Mus musculus	Solute carrier family 22 member 20	Vmax	nan	None	10.1074/jbc.m703467200
Mus musculus	Solute carrier family 22 member 6	Activity	nan	None	10.1074/jbc.274.3.1519
Mus musculus	Solute carrier family 22 member 6	Ki	891250.94	nM	10.1074/jbc.m703467200
Mus musculus	Solute carrier family 22 member 6	Ki	901000.0	nM	10.1074/jbc.m703467200
Mus musculus	Solute carrier family 22 member 6	Vmax	38.3	pmol/hr	10.1074/jbc.m703467200
Mus musculus	Solute carrier family 22 member 8	Activity	48.4	%	10.1124/jpet.103.063370
Mus musculus	Solute carrier family 22 member 8	Activity	nan	None	10.1124/jpet.103.063370
Mus musculus	TA3	ID50	0.008	M	10.1021/jm00346a018
Mus musculus	Thymidylate synthase	IC50	20000.0	nM	10.1021/jm00124a019
Mus musculus	Thymidylate synthase	IC50	20000.0	nM	10.1021/jm00397a031
Mus musculus	Thymidylate synthase	Ki	45000.0	nM	10.1021/jm00347a007
Mycobacterium tuberculosis	Dihydrofolate reductase	IC50	8.25	nM	10.1021/acsmedchemlett.5b00367
Mycobacterium tuberculosis	Dihydrofolate reductase	IC50	8.8	nM	10.1016/j.bmc.2019.02.053
Mycobacterium tuberculosis	Dihydrofolate reductase	IC50	35.0	nM	10.1016/j.ejmech.2017.12.017
Mycobacterium tuberculosis	Mycobacterium tuberculosis	MIC	968.0	nM	10.1021/acsmedchemlett.5b00367
Mycobacterium tuberculosis	Mycobacterium tuberculosis	MIC	3380.0	nM	10.1016/j.bmc.2019.02.053
Mycolicibacterium smegmatis	Mycolicibacterium smegmatis	MIC	2200000.0	nM	10.1016/j.bmc.2019.04.032
Oryctolagus cuniculus	Angiotensin-converting enzyme	IC50	nan	None	None
Oryctolagus cuniculus	Angiotensin-converting enzyme	Ki	nan	None	None
Oryctolagus cuniculus	Arachidonate 15-lipoxygenase	IC50	nan	None	None
Oryctolagus cuniculus	Arachidonate 15-lipoxygenase	Ki	nan	None	None
Oryctolagus cuniculus	Dihydrofolate reductase	ID50	9.0	10'-9mol/L	10.1021/jm00202a013
Oryctolagus cuniculus	Oryctolagus cuniculus	Activity	0.006	None	10.1021/jm9505122
Oryctolagus cuniculus	Oryctolagus cuniculus	Activity	0.05	None	10.1021/jm9505122
Plasmodium berghei	Plasmodium berghei	MCD	640.0	mg kg-1	10.1021/jm00212a010
Plasmodium berghei	Plasmodium berghei	MED	640.0	mg kg-1	10.1021/jm00212a010
Plasmodium falciparum	Hexose transporter 1	Inhibition	0.06	%	10.6019/CHEMBL3433997
Plasmodium falciparum	Hexose transporter 1	Inhibition	2.33	%	10.6019/CHEMBL3433997
Plasmodium falciparum	Hexose transporter 1	Inhibition	2.91	%	10.6019/CHEMBL3433997
Plasmodium falciparum	Plasmodium falciparum	IC50	0.04	nM	10.1038/nchembio.215
Plasmodium falciparum	Plasmodium falciparum	IC50	0.07	nM	10.1038/nchembio.215
Plasmodium falciparum	Plasmodium falciparum	IC50	0.09	nM	10.1038/nchembio.215
Plasmodium falciparum	Plasmodium falciparum	IC50	0.11	nM	10.1038/nchembio.215
Plasmodium falciparum	Plasmodium falciparum	IC50	31.62	nM	10.1038/nchembio.215
Plasmodium falciparum	Plasmodium falciparum	IC50	39.81	nM	10.1038/nchembio.215
Plasmodium falciparum	Plasmodium falciparum	IC50	40.0	nM	10.1128/aac.00308-09
Plasmodium falciparum	Plasmodium falciparum	IC50	49.9	nM	10.1128/aac.00308-09
Plasmodium falciparum	Plasmodium falciparum	IC50	56.63	nM	10.1128/aac.00308-09
Plasmodium falciparum	Plasmodium falciparum	IC50	63.0	nM	10.1128/aac.01689-08
Plasmodium falciparum	Plasmodium falciparum	IC50	79.43	nM	10.1038/nchembio.215
Plasmodium falciparum	Plasmodium falciparum	IC50	83.59	nM	10.1128/aac.00308-09
Plasmodium falciparum	Plasmodium falciparum	IC50	83.6	nM	10.1128/aac.00308-09
Plasmodium falciparum	Plasmodium falciparum	IC50	84.89	nM	10.1128/aac.00308-09
Plasmodium falciparum	Plasmodium falciparum	IC50	100.0	nM	10.1038/nchembio.215
Plasmodium falciparum	Plasmodium falciparum	Inhibition	0.0	%	10.1038/nature09107
Plasmodium falciparum	Plasmodium falciparum	Inhibition	1.0	%	10.1038/nature09107
Plasmodium falciparum	Plasmodium falciparum	Inhibition	44.0	%	10.1038/nature09107
Plasmodium falciparum	Plasmodium falciparum	Inhibition	66.0	%	10.1038/nature09107
Plasmodium falciparum	Plasmodium falciparum	Inhibition	91.0	%	10.1038/nature09107
Plasmodium falciparum	Plasmodium falciparum	Inhibition	92.0	%	10.1038/nature09107
Plasmodium falciparum	Plasmodium falciparum	Inhibition	nan	%	10.1038/nature09107
Plasmodium falciparum	Plasmodium falciparum	Potency	42.6	nM	None
Plasmodium falciparum	Plasmodium falciparum	Potency	1694.4	nM	None
Plasmodium falciparum	Plasmodium falciparum	XC50	100.06	nM	10.1038/nature09107
Plasmodium falciparum	Plasmodium falciparum	XC50	177.55	nM	10.1038/nature09107
Plasmodium falciparum	Plasmodium falciparum	XC50	nan	nM	10.1038/nature09107
Plasmodium falciparum K1	Dihydrofolate reductase	IC50	84.0	nM	10.1016/j.bmc.2017.10.017
Pneumocystis carinii	Dihydrofolate reductase	IC50	1.0	nM	10.1021/jm00012a016
Pneumocystis carinii	Dihydrofolate reductase	IC50	1.0	nM	10.1021/jm00034a015
Pneumocystis carinii	Dihydrofolate reductase	IC50	1.0	nM	10.1021/jm960717q
Pneumocystis carinii	Dihydrofolate reductase	IC50	1.0	nM	10.1021/jm9705420
Pneumocystis carinii	Dihydrofolate reductase	IC50	1.1	nM	10.1021/jm0202369
Pneumocystis carinii	Dihydrofolate reductase	IC50	1.3	nM	10.1021/jm00024a001
Pneumocystis carinii	Dihydrofolate reductase	IC50	1.3	nM	10.1021/jm400086g
Pneumocystis carinii	Dihydrofolate reductase	IC50	1.3	nM	10.1021/jm950786p
Pneumocystis carinii	Dihydrofolate reductase	IC50	1.3	nM	10.1021/jm970055k
Pneumocystis carinii	Dihydrofolate reductase	IC50	13.8	nM	10.1021/jm000200l
Pneumocystis carinii	Dihydrofolate reductase	IC50	880.0	nM	10.1021/jm00024a001
Pneumocystis carinii	Dihydrofolate reductase	Ki	0.008	nM	10.1021/jm00024a001
Pneumocystis carinii	Dihydrofolate reductase; P. carinii vs rat	Selectivity ratio	1.9	None	10.1021/jm950786p
Pneumocystis carinii	Dihydrofolate reductase; P. carinii vs rat	Selectivity ratio	1.9	None	10.1021/jm970055k
Pseudomonas aeruginosa	Pseudomonas aeruginosa	IZ	8.0	mm	10.1016/j.ejmech.2013.05.039
Rattus norvegicus	Aldose reductase	IC50	nan	None	None
Rattus norvegicus	Aldose reductase	Ki	nan	None	None
Rattus norvegicus	Alpha-1a adrenergic receptor	IC50	nan	None	None
Rattus norvegicus	Alpha-1a adrenergic receptor	Ki	nan	None	None
Rattus norvegicus	Alpha-1b adrenergic receptor	IC50	nan	None	None
Rattus norvegicus	Alpha-1b adrenergic receptor	Ki	nan	None	None
Rattus norvegicus	Androgen Receptor	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Rattus norvegicus	Androgen Receptor	IC50	nan	None	None
Rattus norvegicus	Androgen Receptor	Ki	nan	None	None
Rattus norvegicus	Bile salt export pump	IC50	1000000.0	nM	10.1124/dmd.111.040758
Rattus norvegicus	Brain	Fu	0.89	None	10.1124/dmd.110.035998
Rattus norvegicus	Brain	Kp	0.61	None	10.1124/dmd.110.035998
Rattus norvegicus	Brain	Vd	0.68	L.kg-1	10.1124/dmd.110.035998
Rattus norvegicus	Brain	Vdu	0.68	ml	10.1021/jm901036q
Rattus norvegicus	Canalicular multispecific organic anion transporter 1	Activity	nan	None	10.1023/a:1022238506509
Rattus norvegicus	Canalicular multispecific organic anion transporter 1	Ki	236000.0	nM	None
Rattus norvegicus	Canalicular multispecific organic anion transporter 1	Ki	326000.0	nM	None
Rattus norvegicus	Canalicular multispecific organic anion transporter 1	Ki	462000.0	nM	10.1023/a:1011064806507
Rattus norvegicus	Canalicular multispecific organic anion transporter 1	Km	296000.0	nM	None
Rattus norvegicus	Canalicular multispecific organic anion transporter 2	Activity	10.7	%	10.1074/jbc.274.21.15181
Rattus norvegicus	Canalicular multispecific organic anion transporter 2	Activity	18.5	%	10.1074/jbc.274.21.15181
Rattus norvegicus	Canalicular multispecific organic anion transporter 2	Activity	nan	None	10.1074/jbc.274.21.15181
Rattus norvegicus	Canalicular multispecific organic anion transporter 2	Ki	90000.0	nM	10.1023/a:1013699130991
Rattus norvegicus	Canalicular multispecific organic anion transporter 2	Km	4500.0	nM	10.1152/ajpgi.00424.2002
Rattus norvegicus	Canalicular multispecific organic anion transporter 2	Km	11700.0	nM	10.1152/ajpgi.00424.2002
Rattus norvegicus	Cyclooxygenase-1	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Rattus norvegicus	Dihydrofolate reductase	IC50	1.0	nM	10.1021/jm00214a030
Rattus norvegicus	Dihydrofolate reductase	IC50	2.0	nM	10.1021/jm0009639
Rattus norvegicus	Dihydrofolate reductase	IC50	2.5	nM	10.1021/jm021062y
Rattus norvegicus	Dihydrofolate reductase	IC50	2.5	nM	10.1021/jm400086g
Rattus norvegicus	Dihydrofolate reductase	IC50	2.5	nM	10.1021/jm950786p
Rattus norvegicus	Dihydrofolate reductase	IC50	2.5	nM	10.1021/jm970055k
Rattus norvegicus	Dihydrofolate reductase	IC50	3.0	nM	10.1021/jm00012a016
Rattus norvegicus	Dihydrofolate reductase	IC50	3.0	nM	10.1021/jm00034a015
Rattus norvegicus	Dihydrofolate reductase	IC50	3.0	nM	10.1021/jm960717q
Rattus norvegicus	Dihydrofolate reductase	IC50	3.0	nM	10.1021/jm9705420
Rattus norvegicus	Dihydrofolate reductase	IC50	4.6	nM	10.1021/jm00380a011
Rattus norvegicus	Dihydrofolate reductase	Ki	0.073	nM	10.1016/j.bmc.2009.08.044
Rattus norvegicus	Dihydrofolate reductase	Log 1/C	8.13	None	10.1021/jm00361a012
Rattus norvegicus	Dihydrofolate reductase	Log 1/C	8.13	None	10.1021/jm00373a016
Rattus norvegicus	GABA receptor alpha-1 subunit	AC50	10000.0	nM	10.1038/s41467-023-40064-9
Rattus norvegicus	Glutamate (NMDA) receptor subunit zeta 1	AC50	10000.0	nM	10.1038/s41467-023-40064-9
Rattus norvegicus	Glycine receptor	IC50	nan	None	None
Rattus norvegicus	Glycine receptor	Ki	nan	None	None
Rattus norvegicus	H35	IC50	10.0	nM	10.1021/jm00373a014
Rattus norvegicus	H35	Relative activity	1.0	None	10.1021/jm00373a014
Rattus norvegicus	H35R0.3	IC50	85.0	nM	10.1021/jm00105a035
Rattus norvegicus	H35R0.3	IC50	906.0	nM	10.1021/jm00126a023
Rattus norvegicus	H35R0.3	IC50	1800.0	nM	10.1021/jm00373a014
Rattus norvegicus	H35R0.3	IC50	18000.0	nM	10.1021/jm00105a035
Rattus norvegicus	H35R0.3	Relative activity	1.0	None	10.1021/jm00373a014
Rattus norvegicus	Insulin receptor	IC50	nan	None	None
Rattus norvegicus	Insulin receptor	Ki	nan	None	None
Rattus norvegicus	Monocarboxylate transporter 1	Activity	nan	None	10.1211/0022357991776804
Rattus norvegicus	Nitric-oxide synthase, brain	IC50	nan	None	None
Rattus norvegicus	Nitric-oxide synthase, brain	Ki	nan	None	None
Rattus norvegicus	Peripheral myelin protein 22	Potency	99.9	nM	None
Rattus norvegicus	Plasma	Cp(f)	2.9	uM	10.1021/jm901036q
Rattus norvegicus	Plasma	Fu	0.37	None	10.1021/jm901371v
Rattus norvegicus	Plasma	Fu	1.0	None	10.1021/jm901036q
Rattus norvegicus	Plasma	K(p,uu,CSF)	0.007	None	10.1021/jm901036q
Rattus norvegicus	Rattus norvegicus	Activity	0.2795	inches	10.1021/ml500389m
Rattus norvegicus	Rattus norvegicus	Activity	20.0	%	10.1016/j.bmcl.2008.10.116
Rattus norvegicus	Rattus norvegicus	Activity	181.7	g	10.1021/ml500389m
Rattus norvegicus	Rattus norvegicus	Activity	nan	None	10.1016/j.bmc.2019.115247
Rattus norvegicus	Rattus norvegicus	Activity	nan	None	10.1016/j.bmcl.2012.04.129
Rattus norvegicus	Rattus norvegicus	Activity	nan	None	10.1016/j.bmcl.2018.01.009
Rattus norvegicus	Rattus norvegicus	Activity	nan	None	10.1016/j.bmcl.2019.04.011
Rattus norvegicus	Rattus norvegicus	Activity	nan	None	10.1016/j.ejmech.2021.113514
Rattus norvegicus	Rattus norvegicus	Activity	nan	None	10.1021/acs.jnatprod.6b00554
Rattus norvegicus	Rattus norvegicus	Activity	nan	None	10.1021/jm501127s
Rattus norvegicus	Rattus norvegicus	ALB	33000.0	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	ALB	34300.0	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	ALB	39000.0	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	ALB	39300.0	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	ALB	39700.0	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	ALB	40500.0	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	ALB	41700.0	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	ALB	42000.0	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	ALB	43000.0	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	ALP	111.0	U.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	ALP	155.5	U.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	ALP	163.0	U.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	ALP	284.5	U.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	ALP	317.17	U.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	ALP	347.0	U.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	ALP	402.5	U.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	ALP	442.33	U.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	ALP	510.0	U.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	ALP	597.33	U.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	ALT	18.0	U.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	ALT	18.33	U.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	ALT	26.33	U.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	ALT	52.33	U.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	ALT	52.5	U.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	ALT	62.83	U.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	ALT	69.0	U.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	ALT	76.67	U.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	ALT	76.83	U.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	ALT	93.67	U.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	AST	57.67	U.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	AST	64.25	U.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	AST	80.33	U.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	AST	81.17	U.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	AST	81.33	U.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	AST	92.5	U.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	AST	97.17	U.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	AST	107.0	U.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	AST	118.33	U.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	AST	122.83	U.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	AUC	838.0	nM l-1 hr-1	10.1021/jm0009639
Rattus norvegicus	Rattus norvegicus	AUC inf	1559.0	nM l-1 hr-1	10.1021/jm0009639
Rattus norvegicus	Rattus norvegicus	BASO	0.0	cells.uL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	BASOLE	0.0	%	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	BILI	1.3	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	BILI	1.8	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	BILI	2.0	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	BILI	2.5	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	BUN	100.0	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	BUN	123.3	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	BUN	140.0	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	BUN	143.3	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	BUN	147.5	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	BUN	153.3	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	BUN	160.0	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	BUN	200.0	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	BUN	230.0	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	CHLORIDE	94.5	mEq.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	CHLORIDE	95.33	mEq.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	CHLORIDE	95.5	mEq.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	CHLORIDE	98.33	mEq.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	CHLORIDE	98.5	mEq.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	CHLORIDE	99.5	mEq.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	CHLORIDE	100.33	mEq.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	CHLORIDE	100.67	mEq.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	CHLORIDE	101.83	mEq.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	CHLORIDE	102.33	mEq.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	CHOL	360.0	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	CHOL	380.0	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	CHOL	423.3	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	CHOL	575.0	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	CHOL	671.7	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	CHOL	686.7	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	CHOL	721.7	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	CHOL	748.3	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	CHOL	950.0	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	CHOL	1055.0	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	CK	132.0	U.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	CK	140.33	U.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	CK	216.83	U.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	CK	305.17	U.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	CK	312.33	U.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	CK	448.33	U.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	CK	556.67	U.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	CK	659.17	U.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	CK	1224.33	U.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	CK	1782.67	U.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	CL	9.6	mL.min-1.kg-1	10.1124/dmd.112.049312
Rattus norvegicus	Rattus norvegicus	CL	11.0	mL.min-1.kg-1	10.1021/jm0009639
Rattus norvegicus	Rattus norvegicus	CL	12.47	mL.min-1.kg-1	10.1124/dmd.112.049312
Rattus norvegicus	Rattus norvegicus	Cmax	266.0	nM l-1 hr-1	10.1021/jm0009639
Rattus norvegicus	Rattus norvegicus	Cmax	8257.0	nM l-1 hr-1	10.1021/jm0009639
Rattus norvegicus	Rattus norvegicus	CO2	18670000.0	nM	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	CO2	20000000.0	nM	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	CO2	24000000.0	nM	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	CO2	25330000.0	nM	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	CO2	25500000.0	nM	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	CO2	26000000.0	nM	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	CO2	26400000.0	nM	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	CO2	31170000.0	nM	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	CO2	31250000.0	nM	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	CO2	33670000.0	nM	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	CREAT	1.0	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	CREAT	1.1	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	CREAT	1.3	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	CREAT	1.9	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	CREAT	2.1	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	CREAT	2.3	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	CREAT	3.2	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	CREAT	3.7	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	ED50	0.058	mg.kg-1	10.1021/jm970085n
Rattus norvegicus	Rattus norvegicus	EOS	0.0	cells.uL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	EOS	14.67	cells.uL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	EOS	33.0	cells.uL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	EOS	36.33	cells.uL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	EOS	68.0	cells.uL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	EOS	94.0	cells.uL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	EOS	104.17	cells.uL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	EOS	124.67	cells.uL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	EOS	331.5	cells.uL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	EOSLE	0.0	%	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	EOSLE	0.17	%	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	EOSLE	0.5	%	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	EOSLE	0.67	%	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	EOSLE	1.0	%	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	EOSLE	1.33	%	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	EOSLE	1.83	%	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	F	5.8	%	10.1021/jm0009639
Rattus norvegicus	Rattus norvegicus	GLUC	1420.0	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	GLUC	1580.0	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	GLUC	1606.7	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	GLUC	1641.7	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	GLUC	1655.0	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	GLUC	1656.7	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	GLUC	1657.5	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	GLUC	1913.3	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	GLUC	2076.7	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	GLUC	2376.7	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	HCT	31.57	%	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	HCT	32.87	%	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	HCT	33.22	%	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	HCT	33.67	%	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	HCT	33.82	%	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	HCT	37.2	%	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	HCT	37.7	%	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	HCT	39.4	%	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	HCT	41.87	%	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	HCT	43.93	%	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	HGB	122000.0	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	HGB	129500.0	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	HGB	132000.0	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	HGB	133800.0	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	HGB	134800.0	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	HGB	143000.0	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	HGB	152800.0	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	HGB	163300.0	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	HGB	172700.0	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	Inhibition	nan	%	10.1016/j.ejmech.2019.04.020
Rattus norvegicus	Rattus norvegicus	LDH	83.5	U.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	LDH	94.5	U.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	LDH	131.67	U.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	LDH	155.83	U.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	LDH	171.0	U.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	LDH	246.67	U.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	LDH	271.5	U.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	LDH	290.67	U.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	LDH	368.67	U.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	LDH	410.67	U.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	LIPASE	6.67	U.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	LIPASE	6.83	U.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	LIPASE	8.0	U.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	LIPASE	9.17	U.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	LIPASE	9.83	U.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	LIPASE	11.67	U.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	LIPASE	16.0	U.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	LIPASE	37.0	U.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	LIPASE	85.83	U.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	LYM	2213.67	cells.uL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	LYM	2276.25	cells.uL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	LYM	3442.0	cells.uL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	LYM	6455.33	cells.uL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	LYM	6857.33	cells.uL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	LYM	7221.33	cells.uL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	LYM	9048.5	cells.uL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	LYM	9629.83	cells.uL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	LYM	14547.0	cells.uL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	LYM	15021.67	cells.uL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	LYMLE	66.75	%	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	LYMLE	69.0	%	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	LYMLE	70.0	%	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	LYMLE	79.67	%	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	LYMLE	82.33	%	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	LYMLE	84.67	%	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	LYMLE	86.67	%	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	LYMLE	87.5	%	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	LYMLE	89.17	%	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	LYMLE	90.17	%	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	MCH	22.43	pg	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	MCH	23.57	pg	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	MCH	23.72	pg	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	MCH	24.03	pg	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	MCH	24.07	pg	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	MCH	24.27	pg	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	MCH	24.77	pg	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	MCH	25.05	pg	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	MCH	25.17	pg	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	MCH	25.28	pg	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	MCHC	379300.0	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	MCHC	384700.0	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	MCHC	386800.0	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	MCHC	388000.0	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	MCHC	390700.0	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	MCHC	393000.0	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	MCHC	394000.0	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	MCHC	397300.0	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	MCHC	397800.0	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	MCHC	399200.0	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	MCV	57.8	fL	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	MCV	60.18	fL	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	MCV	60.33	fL	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	MCV	61.23	fL	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	MCV	62.17	fL	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	MCV	62.97	fL	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	MCV	63.3	fL	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	MCV	63.38	fL	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	MCV	63.93	fL	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	MCV	64.33	fL	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	MONO	0.0	cells.uL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	MONO	4.67	cells.uL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	MONO	25.67	cells.uL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	MONO	42.0	cells.uL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	MONO	72.5	cells.uL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	MONO	80.17	cells.uL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	MONO	172.67	cells.uL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	MONO	225.67	cells.uL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	MONO	292.0	cells.uL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	MONO	376.5	cells.uL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	MONOLE	0.0	%	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	MONOLE	0.33	%	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	MONOLE	0.67	%	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	MONOLE	0.83	%	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	MONOLE	1.0	%	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	MONOLE	1.67	%	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	MONOLE	1.83	%	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	MONOLE	2.0	%	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	MONOLE	2.67	%	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	NEUTLE	9.0	%	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	NEUTLE	10.0	%	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	NEUTLE	12.33	%	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	NEUTLE	13.67	%	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	NEUTLE	15.0	%	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	NEUTLE	16.5	%	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	NEUTLE	27.67	%	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	NEUTLE	29.0	%	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	NEUTLE	33.25	%	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	NEUTSG	381.67	cells.uL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	NEUTSG	716.0	cells.uL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	NEUTSG	959.0	cells.uL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	NEUTSG	1049.67	cells.uL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	NEUTSG	1198.75	cells.uL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	NEUTSG	1521.67	cells.uL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	NEUTSG	1640.17	cells.uL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	NEUTSG	1648.0	cells.uL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	NEUTSG	2345.33	cells.uL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	NEUTSG	3070.33	cells.uL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	PHOS	81.8	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	PHOS	101.0	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	PHOS	104.0	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	PHOS	106.5	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	PHOS	110.3	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	PHOS	115.0	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	PHOS	121.0	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	PHOS	135.8	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	PHOS	136.8	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	PHOS	146.3	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	PLAT	923330.0	cells.uL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	PLAT	997670.0	cells.uL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	PLAT	1097000.0	cells.uL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	PLAT	1137670.0	cells.uL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	PLAT	1142670.0	cells.uL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	PLAT	1149000.0	cells.uL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	PLAT	1170250.0	cells.uL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	PLAT	1211330.0	cells.uL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	PLAT	1274500.0	cells.uL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	PLAT	1275330.0	cells.uL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	POTASSIUM	5.16	mEq.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	POTASSIUM	5.46	mEq.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	POTASSIUM	5.6	mEq.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	POTASSIUM	5.79	mEq.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	POTASSIUM	5.95	mEq.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	POTASSIUM	6.28	mEq.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	POTASSIUM	6.38	mEq.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	POTASSIUM	6.55	mEq.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	POTASSIUM	6.72	mEq.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	POTASSIUM	6.83	mEq.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	PROT	47300.0	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	PROT	52700.0	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	PROT	55500.0	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	PROT	56300.0	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	PROT	57200.0	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	PROT	58800.0	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	PROT	60000.0	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	PROT	61000.0	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	PROT	62700.0	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	PROT	63200.0	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	RBC	5080000.0	cells.uL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	RBC	5240000.0	cells.uL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	RBC	5350000.0	cells.uL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	RBC	5360000.0	cells.uL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	RBC	5460000.0	cells.uL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	RBC	5780000.0	cells.uL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	RBC	5900000.0	cells.uL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	RBC	6820000.0	cells.uL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	RBC	6930000.0	cells.uL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	RBC	7170000.0	cells.uL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	RBCNUC	0.0	/100WBC	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	RBCNUC	0.17	/100WBC	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	RBCNUC	0.33	/100WBC	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	SODIUM	137.0	mEq.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	SODIUM	139.5	mEq.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	SODIUM	139.65	mEq.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	SODIUM	141.9	mEq.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	SODIUM	142.1	mEq.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	SODIUM	143.02	mEq.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	SODIUM	144.0	mEq.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	SODIUM	145.97	mEq.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	SODIUM	147.55	mEq.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	SODIUM	149.5	mEq.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	Suppression	75.0	%	10.1021/jm9605288
Rattus norvegicus	Rattus norvegicus	Suppression	92.0	%	10.1021/jm9605288
Rattus norvegicus	Rattus norvegicus	T1/2	0.9	hr	10.1021/jm0009639
Rattus norvegicus	Rattus norvegicus	Tissue Severity Score	nan	None	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	Tmax	0.67	hr	10.1021/jm0009639
Rattus norvegicus	Rattus norvegicus	URATE	5.3	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	URATE	6.8	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	URATE	8.0	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	URATE	10.2	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	URATE	11.2	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	URATE	13.7	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	URATE	14.7	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	URATE	16.7	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	URATE	17.0	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	URATE	24.0	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	Vdss	0.36	L.kg-1	10.1021/jm0009639
Rattus norvegicus	Rattus norvegicus	WBC	2600.0	cells.uL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	WBC	3480.0	cells.uL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	WBC	5200.0	cells.uL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	WBC	7230.0	cells.uL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	WBC	8170.0	cells.uL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	WBC	9830.0	cells.uL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	WBC	10680.0	cells.uL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	WBC	10770.0	cells.uL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	WBC	16580.0	cells.uL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	WBC	18800.0	cells.uL-1	10.6019/CHEMBL3885881
Rattus norvegicus	RBL-1	ID50	0.003	uM	10.1021/jm00137a016
Rattus norvegicus	Serotonin 1a (5-HT1a) receptor	IC50	nan	None	None
Rattus norvegicus	Serotonin 1a (5-HT1a) receptor	Ki	nan	None	None
Rattus norvegicus	Serotonin 1b (5-HT1b) receptor	IC50	nan	None	None
Rattus norvegicus	Serotonin 1b (5-HT1b) receptor	Ki	nan	None	None
Rattus norvegicus	Serum	Drug metabolism	nan	None	10.1021/jm00217a012
Rattus norvegicus	Solute carrier family 22 member 6	Activity	nan	None	10.1016/s0014-5793(98)01328-3
Rattus norvegicus	Solute carrier family 22 member 6	Activity	nan	None	10.1074/jbc.272.30.18526
Rattus norvegicus	Solute carrier family 22 member 7	Activity	nan	None	10.1016/s0014-5793(98)00585-7
Rattus norvegicus	Solute carrier family 22 member 8	Activity	nan	None	10.1074/jbc.274.19.13675
Rattus norvegicus	Solute carrier organic anion transporter family member 1A1	Activity	nan	None	10.1007/s004240100697
Rattus norvegicus	Solute carrier organic anion transporter family member 1A3	Activity	nan	None	None
Rattus norvegicus	Solute carrier organic anion transporter family member 1A3	Km	1000.0	nM	10.1074/jbc.271.34.20719
Rattus norvegicus	Solute carrier organic anion transporter family member 1A3	Km	1800.0	nM	None
Rattus norvegicus	Solute carrier organic anion transporter family member 1A3	Km	2100.0	nM	10.1016/s0014-5793(99)01221-1
Rattus norvegicus	Solute carrier organic anion transporter family member 1A4	Activity	nan	None	10.1073/pnas.94.19.10346
Rattus norvegicus	Solute carrier organic anion transporter family member 1A5	Activity	nan	None	10.1007/s004240100697
Rattus norvegicus	Solute carrier organic anion transporter family member 1B2	Activity	nan	None	10.1007/s004240100697
Rattus norvegicus	Thioredoxin reductase 1, cytoplasmic	IC50	nan	None	10.1021/acs.jmedchem.6b01253
Rattus norvegicus	Thioredoxin reductase 1, cytoplasmic	Potency	17782.8	nM	None
Rattus norvegicus	Thioredoxin reductase 1, cytoplasmic	Potency	18887.6	nM	None
Rattus norvegicus	Thioredoxin reductase 1, cytoplasmic	Potency	25118.9	nM	None
Rattus norvegicus	Thioredoxin reductase 1, cytoplasmic	Potency	56234.1	nM	None
Rattus norvegicus	Thymidylate synthase	IC50	nan	None	10.1021/jm000130i
Rattus norvegicus	Voltage-gated L-type calcium channel alpha-1C subunit	AC50	10000.0	nM	10.1038/s41467-023-40064-9
Rattus norvegicus	Voltage-gated N-type calcium channel alpha-1B subunit	AC50	10000.0	nM	10.1038/s41467-023-40064-9
Rattus norvegicus	W256	ED50	0.02	uM	10.1021/jm00177a025
Saccharomyces cerevisiae	Saccharomyces cerevisiae	IZ	1.0	mm	10.1016/j.ejmech.2010.07.050
Saccharomyces cerevisiae	Saccharomyces cerevisiae	IZ	8.0	mm	10.1016/j.ejmech.2010.07.050
Saccharomyces cerevisiae	Saccharomyces cerevisiae	Potency	7307.8	nM	None
Severe acute respiratory syndrome coronavirus 2	Replicase polyprotein 1ab	Inhibition	-4.284	%	10.6019/CHEMBL4495564
Severe acute respiratory syndrome coronavirus 2	Replicase polyprotein 1ab	Inhibition	16.96	%	10.6019/CHEMBL4495564
Severe acute respiratory syndrome coronavirus 2	SARS-CoV-2	Hit score	0.1078	None	10.1101/2020.04.21.054387
Severe acute respiratory syndrome coronavirus 2	SARS-CoV-2	IC50	50.0	nM	10.6019/CHEMBL4495565
Severe acute respiratory syndrome coronavirus 2	SARS-CoV-2	IC50 relative	0.0551	uM	10.6019/EOS300033
Severe acute respiratory syndrome coronavirus 2	SARS-CoV-2	Inhibition	-4.89	%	10.21203/rs.3.rs-23951/v1
Severe acute respiratory syndrome coronavirus 2	SARS-CoV-2	Inhibition	45.35	%	10.6019/CHEMBL4495565
Severe acute respiratory syndrome coronavirus 2	SARS-CoV-2	Inhibition	49.83	%	10.6019/CHEMBL4495565
Staphylococcus aureus	Dihydrofolate reductase	Ki	0.004	nM	10.1021/jm401204g
Staphylococcus aureus	Dihydrofolate reductase	Ki	1.0	nM	10.1021/acsmedchemlett.6b00120
Staphylococcus aureus	Staphylococcus aureus	IZ	8.0	mm	10.1016/j.ejmech.2013.05.039
Staphylococcus aureus	Staphylococcus aureus	MIC	40.0	ug.mL-1	10.1021/acsmedchemlett.6b00120
Staphylococcus aureus	Staphylococcus aureus	MIC	64.0	ug.mL-1	10.1021/jm401204g
Staphylococcus aureus	Staphylococcus aureus	MIC50	20.0	ug.mL-1	10.1021/acsmedchemlett.6b00120
Staphylococcus aureus	Staphylococcus aureus	MIC90	100.0	ug.mL-1	10.1021/acsmedchemlett.6b00120
Toxoplasma gondii	Dihydrofolate reductase	Activity	0.33	None	10.1021/jm061027h
Toxoplasma gondii	Dihydrofolate reductase	IC50	1.4	nM	10.1021/jm970055k
Toxoplasma gondii	Dihydrofolate reductase	IC50	11.0	nM	10.1016/j.bmc.2009.11.029
Toxoplasma gondii	Dihydrofolate reductase	IC50	11.0	nM	10.1021/jm010575m
Toxoplasma gondii	Dihydrofolate reductase	IC50	11.0	nM	10.1021/jm058234m
Toxoplasma gondii	Dihydrofolate reductase	IC50	11.0	nM	10.1021/jm800244v
Toxoplasma gondii	Dihydrofolate reductase	IC50	14.0	nM	10.1021/jm00012a016
Toxoplasma gondii	Dihydrofolate reductase	IC50	14.0	nM	10.1021/jm00034a015
Toxoplasma gondii	Dihydrofolate reductase	IC50	14.0	nM	10.1021/jm950786p
Toxoplasma gondii	Dihydrofolate reductase	IC50	14.0	nM	10.1021/jm960717q
Toxoplasma gondii	Dihydrofolate reductase	IC50	14.0	nM	10.1021/jm9705420
Toxoplasma gondii	Dihydrofolate reductase	IC50	22.0	nM	10.1016/j.bmc.2011.03.067
Toxoplasma gondii	Dihydrofolate reductase	IC50	22.0	nM	10.1021/jm000130i
Toxoplasma gondii	Dihydrofolate reductase	IC50	22.0	nM	10.1021/jm000200l
Toxoplasma gondii	Dihydrofolate reductase	IC50	22.0	nM	10.1021/jm0202369
Toxoplasma gondii	Dihydrofolate reductase	IC50	22.0	nM	10.1021/jm950786p
Toxoplasma gondii	Dihydrofolate reductase	IC50	33.0	nM	10.1016/j.bmc.2012.05.068
Toxoplasma gondii	Dihydrofolate reductase	IC50	33.0	nM	10.1021/jm8006933
Toxoplasma gondii	Dihydrofolate reductase	IC50	33.0	nM	10.1021/jm900490a
Toxoplasma gondii	Dihydrofolate reductase	IC50	71.0	nM	10.1021/acsmedchemlett.6b00328
Toxoplasma gondii	Dihydrofolate reductase	IC50	78.3	nM	10.1021/acs.jmedchem.8b01754
Toxoplasma gondii	Dihydrofolate reductase	IC50	1100.0	nM	10.1021/jm0100382
Toxoplasma gondii	Dihydrofolate reductase	IC50	14000.0	nM	10.1021/jm061027h
Toxoplasma gondii	Dihydrofolate reductase	IC50	18000.0	nM	10.1016/j.bmc.2009.11.029
Toxoplasma gondii	Dihydrofolate reductase	IC50	18000.0	nM	10.1016/j.bmc.2011.03.067
Toxoplasma gondii	Dihydrofolate reductase	IC50	18000.0	nM	10.1021/jm058234m
Toxoplasma gondii	Dihydrofolate reductase	IC50	18000.0	nM	10.1021/jm800244v
Toxoplasma gondii	Dihydrofolate reductase	IC50	nan	None	10.1021/jm8006933
Toxoplasma gondii	Dihydrofolate reductase	IC50	nan	None	10.1021/jm900490a
Toxoplasma gondii	Dihydrofolate reductase; T. gondii vs rat	Selectivity ratio	0.18	None	10.1021/jm970055k
Toxoplasma gondii	Dihydrofolate reductase; T. gondii vs rat	Selectivity ratio	0.2	None	10.1021/jm950786p
Trypanosoma brucei	6-phospho-1-fructokinase	Potency	37933.0	nM	None
Trypanosoma brucei	Trypanosoma brucei	Activity	24.25	%	10.1016/j.ejmech.2018.01.043
Trypanosoma brucei	Trypanosoma brucei	EC50	3500.0	nM	10.1016/j.ejmech.2018.01.043
Trypanosoma brucei	Trypanosoma brucei	EC50	3600.0	nM	10.1016/j.ejmech.2018.01.043
Trypanosoma brucei brucei	Trypanosoma brucei brucei	GI	19.0	%	10.1016/j.ejmech.2020.112047
Trypanosoma brucei brucei	Trypanosoma brucei brucei	IC50	11.0	nM	10.1021/jm500483b
Trypanosoma brucei brucei	Trypanosoma brucei brucei	IC50	3660.0	nM	10.1021/jm500483b
Trypanosoma cruzi	Bifunctional dihydrofolate reductase-thymidylate synthase	IC50	110.0	nM	10.1016/j.bmc.2021.116577
None	ADMET	Activity	53.85	%	10.1007/s00044-012-9979-z
None	ADMET	Activity	nan	None	10.1016/j.bmcl.2019.04.011
None	ADMET	AUC	181.78	ng.hr.mL-1	10.1021/acs.jmedchem.1c01403
None	ADMET	AUC	272.67	ng.hr.mL-1	10.1021/acs.jmedchem.1c01403
None	ADMET	B(DPB)	49.9	%	10.1021/jm040760a
None	ADMET	Binding energy	12.9	kCal mol-1	10.1021/jm00378a021
None	ADMET	BPR	0.004	None	10.1021/jm901036q
None	ADMET	CL	1.2	mL.min-1.kg-1	10.1002/jps.20373
None	ADMET	CL	1.5	mL.min-1.kg-1	10.1016/j.bmc.2019.115247
None	ADMET	CL	2.1	mL.min-1.kg-1	10.1124/dmd.108.020479
None	ADMET	CL	2.5	mL.min-1.kg-1	10.1002/jps.20373
None	ADMET	CL	8.0	mL.min-1.kg-1	10.1002/jps.20373
None	ADMET	CL	12.0	mL.min-1.kg-1	10.1002/jps.20373
None	ADMET	Cmax	100.0	nM	10.1021/acs.jmedchem.1c01403
None	ADMET	Cmax	200.0	nM	10.1021/acs.jmedchem.1c01403
None	ADMET	Cmax	1000000.0	nM	10.1021/acs.jnatprod.6b00362
None	ADMET	delta logD	0.9	None	10.1021/jm0000564
None	ADMET	Drug excretion	10.0	%	10.1124/dmd.112.049312
None	ADMET	Drug excretion	64.0	%	10.1124/dmd.112.049312
None	ADMET	Drugexcretion	8.7	%	10.1039/d0md00051e
None	ADMET	Drug metabolism	55.4	%	10.1021/acs.jmedchem.7b00762
None	ADMET	Drug metabolism	98.0	%	10.1039/d0md00051e
None	ADMET	Drug uptake	3.2	%	10.1124/dmd.112.049254
None	ADMET	Drug uptake	36.2	%	10.1124/dmd.112.049254
None	ADMET	Drug uptake	75.8	%	10.1124/dmd.112.049254
None	ADMET	Drug uptake	90.0	%	10.1124/dmd.112.049254
None	ADMET	F	18.0	%	10.1039/d0md00051e
None	ADMET	F	42.0	%	10.1039/d0md00051e
None	ADMET	F	79.0	%	10.1021/jm0000564
None	ADMET	FA	59.0	%	10.1021/jm049711o
None	ADMET	GI50	nan	None	10.1016/j.ejmech.2010.11.013
None	ADMET	IC50	0.00502	ug.mL-1	10.1021/jm00106a012
None	ADMET	IC50	24.0	nM	10.1021/jm9605288
None	ADMET	IC50	180.0	nM	10.1016/j.bmcl.2007.03.012
None	ADMET	IC50	216.0	nM	10.1021/jm401139z
None	ADMET	IC50	1000.0	nM	10.1021/jm200739e
None	ADMET	IC50	1000.0	nM	10.1021/jm401139z
None	ADMET	IC50	9200.0	nM	10.1016/s0960-894x(99)00213-9
None	ADMET	IC50	14500.0	nM	10.1021/jm950514m
None	ADMET	IC50	nan	None	10.1021/np500836y
None	ADMET	K	0.19	min-1	10.1021/jm00352a026
None	ADMET	Km	166.0	None	10.1021/jm00105a070
None	ADMET	Km	42000.0	nM	10.1021/jm00078a004
None	ADMET	Km	42000.0	nM	10.1021/jm00165a021
None	ADMET	K(p,uu,brain)	0.006	None	10.1021/jm901036q
None	ADMET	LC50	nan	None	10.1016/j.ejmech.2010.11.013
None	ADMET	LD50	0.82	mg.kg-1	10.1021/jm970085n
None	ADMET	LD50	5.0	mg.kg-1	10.1016/j.ejmech.2019.01.017
None	ADMET	Lethal dose	40.0	mg kg-1	10.1021/jm970085n
None	ADMET	log Pe	-8.0	None	10.1021/jm061045z
None	ADMET	Log Pe	-4.7	cm s-1	10.1021/jm001020e
None	ADMET	MRT	3.4	hr	10.1124/dmd.108.020479
None	ADMET	Papp	0.02	cm/s * 10E6	10.1021/jm049711o
None	ADMET	Papp	0.03	cm/s * 10E6	10.1021/jm049711o
None	ADMET	Papp	1.1	ucm/s	10.1124/dmd.110.034629
None	ADMET	Papp	1.2	ucm/s	10.1124/dmd.110.034629
None	ADMET	Papp	1.5	ucm/s	10.1124/dmd.110.034629
None	ADMET	Papp	5.2	cm/s * 10E6	10.1021/jm049711o
None	ADMET	Papp	92.0	cm/s * 10E6	10.1021/jm049711o
None	ADMET	pBBB	1.7	%	10.1039/d0md00051e
None	ADMET	permeability	150.0	10'-6 cm/s	10.1016/j.bmc.2019.115247
None	ADMET	PPB	46.55	%	10.6019/CHEMBL3301361
None	ADMET	Rate constant	0.9	None	10.1021/jm00101a023
None	ADMET	Ratio	-11.0	None	10.1124/dmd.110.034629
None	ADMET	Ratio	0.024	None	10.1021/jm00165a021
None	ADMET	Ratio	0.8	None	10.1124/dmd.110.034629
None	ADMET	Ratio	0.9	None	10.1021/jm00105a070
None	ADMET	Ratio	0.9	None	10.1124/dmd.110.034629
None	ADMET	Ratio	14.0	None	10.1124/dmd.110.034629
None	ADMET	Ratio	30.0	None	10.1124/dmd.110.034629
None	ADMET	Ratio IC50	1.0	None	10.1016/j.bmcl.2016.04.096
None	ADMET	Relative Vmax	0.6	None	10.1021/jm00078a004
None	ADMET	Relative Vmax	0.99	None	10.1021/jm00105a070
None	ADMET	Relative Vmax	1.0	None	10.1021/jm00165a021
None	ADMET	Selectivity index	1.0	None	10.6019/CHEMBL4495565
None	ADMET	Stability	nan	%	10.1016/j.bmc.2019.115247
None	ADMET	t1/2	nan	None	10.1016/j.bmc.2019.115247
None	ADMET	T1/2	2.0	hr	10.1039/d0md00051e
None	ADMET	T1/2	3.9	hr	10.1124/dmd.108.020479
None	ADMET	T1/2	24.0	hr	10.1016/j.bmc.2019.115247
None	ADMET	TGI	nan	None	10.1016/j.ejmech.2010.11.013
None	ADMET	TI	4.0	None	10.1021/jm00195a002
None	ADMET	TI	11.0	None	10.1021/jm00195a002
None	ADMET	Tmax	1.0	hr	10.1021/acs.jmedchem.1c01403
None	ADMET	Vdss	0.4	mL/min/kg	10.1002/jps.20373
None	ADMET	Vdss	0.43	L.kg-1	10.1124/dmd.108.020479
None	ADMET	Vdss	0.54	L.kg-1	10.1002/jps.20373
None	ADMET	Vdss	0.67	L.kg-1	10.1002/jps.20373
None	ADMET	Vdss	1.2	L.kg-1	10.1002/jps.20373
None	ADMET	V/K	0.015	None	10.1021/jm00078a004
None	ADMET	Vmax	0.82	None	10.1021/jm0202369
None	ADMET	Vmax	7.77	nM min-1 g-1	10.1021/jm00352a026
None	carcinoma cell line	EC50	13.8	nM	10.1021/jm000200l
None	carcinoma cell line	EC50	14.5	nM	10.1021/jm000200l
None	EBV-positive nasopharyngeal cell line	Reduction	60.0	%	10.1021/jm00366a004
None	EBV-positive nasopharyngeal cell line	Reduction	99.0	%	10.1021/jm00366a004
None	EBV-positive nasopharyngeal cell line	Survival	0.01	None	10.1021/jm00366a004
None	EBV-positive nasopharyngeal cell line	Survival	0.4	None	10.1021/jm00366a004
None	Epidermoid carcinoma cell line	ED50	0.001	uM	10.1021/jm00142a025
None	Epithelial cell	Influx Ki	339.0	uM	10.1021/jm00146a008
None	Hepatotoxicity	Alkaline Phosphatase Increase - Activity Score	nan	None	10.2174/1570163043334794
None	Hepatotoxicity	Alkaline Phosphatase Increase - Index Value	nan	None	10.2174/1570163043334794
None	Hepatotoxicity	Alkaline Phosphatase Increase - Number of Reports	nan	None	10.2174/1570163043334794
None	Hepatotoxicity	Composite Activity - Active	2.0	None	10.2174/1570163043334794
None	Hepatotoxicity	Composite Activity - Marginal	1.0	None	10.2174/1570163043334794
None	Hepatotoxicity	Composite Activity - Score	nan	None	10.2174/1570163043334794
None	Hepatotoxicity	GGT Increase - Activity Score	nan	None	10.2174/1570163043334794
None	Hepatotoxicity	GGT Increase - Index Value	nan	None	10.2174/1570163043334794
None	Hepatotoxicity	GGT Increase - Number of Reports	nan	None	10.2174/1570163043334794
None	Hepatotoxicity	Hepatotoxicity	nan	None	10.1021/tx1000865
None	Hepatotoxicity	Hepatotoxicity	nan	None	10.1021/tx900326k
None	Hepatotoxicity	Hepatotoxicity	nan	None	10.1124/dmd.110.035113
None	Hepatotoxicity	HepSE_bilirubinemia	1.0	None	10.1371/journal.pcbi.1002310
None	Hepatotoxicity	HepSE_cholecystitis	0.0	None	10.1371/journal.pcbi.1002310
None	Hepatotoxicity	HepSE_cholelithiasis	0.0	None	10.1371/journal.pcbi.1002310
None	Hepatotoxicity	HepSE_cirrhosis	1.0	None	10.1371/journal.pcbi.1002310
None	Hepatotoxicity	HepSE_Combined Scores	5.0	None	10.1371/journal.pcbi.1002310
None	Hepatotoxicity	HepSE_elevated liver function tests	1.0	None	10.1371/journal.pcbi.1002310
None	Hepatotoxicity	HepSE_hepatic failure	1.0	None	10.1371/journal.pcbi.1002310
None	Hepatotoxicity	HepSE_hepatic necrosis	0.0	None	10.1371/journal.pcbi.1002310
None	Hepatotoxicity	HepSE_hepatitis	1.0	None	10.1371/journal.pcbi.1002310
None	Hepatotoxicity	HepSE_hepatomegaly	0.0	None	10.1371/journal.pcbi.1002310
None	Hepatotoxicity	HepSE_jaundice	0.0	None	10.1371/journal.pcbi.1002310
None	Hepatotoxicity	HepSE_liver disease	0.0	None	10.1371/journal.pcbi.1002310
None	Hepatotoxicity	HepSE_liver fatty	0.0	None	10.1371/journal.pcbi.1002310
None	Hepatotoxicity	HepSE_liver function tests abnormal	0.0	None	10.1371/journal.pcbi.1002310
None	Hepatotoxicity	LDH Increase - Activity Score	nan	None	10.2174/1570163043334794
None	Hepatotoxicity	LDH Increase - Index Value	3.5	None	10.2174/1570163043334794
None	Hepatotoxicity	LDH Increase - Number of Reports	4.0	None	10.2174/1570163043334794
None	Hepatotoxicity	LTKB_BD DILI severity score	3.0	None	10.1016/j.drudis.2011.05.007
None	Hepatotoxicity	SGOT Increase - Activity Score	nan	None	10.2174/1570163043334794
None	Hepatotoxicity	SGOT Increase - Index Value	5.3	None	10.2174/1570163043334794
None	Hepatotoxicity	SGOT Increase - Number of Reports	4.0	None	10.2174/1570163043334794
None	Hepatotoxicity	SGPT Increase - Activity Score	nan	None	10.2174/1570163043334794
None	Hepatotoxicity	SGPT Increase - Index Value	6.4	None	10.2174/1570163043334794
None	Hepatotoxicity	SGPT Increase - Number of Reports	4.0	None	10.2174/1570163043334794
None	L1210 (1565)	ID50	0.1	ug ml-1	10.1021/jm00077a017
None	Molecular identity unknown	IC50	13.0	nM	10.1021/jm50001a021
None	Molecular identity unknown	IC50	14.0	nM	10.1021/jm50001a021
None	Molecular identity unknown	IC50	32.0	nM	10.1021/jm50001a021
None	Molecular identity unknown	IC50	71.0	nM	10.1021/jm50001a021
None	Molecular identity unknown	IC50	150.0	nM	10.1021/jm50001a021
None	Molecular identity unknown	IC50	250.0	nM	10.1021/jm50001a021
None	Molecular identity unknown	Potency	44.7	nM	None
None	NON-PROTEIN TARGET	AbsAC35_uM	0.0224	uM	None
None	NON-PROTEIN TARGET	AbsAC35_uM	0.0275	uM	None
None	NON-PROTEIN TARGET	Activity	54.08	%	10.1007/s00044-012-9979-z
None	NON-PROTEIN TARGET	Activity	64.6	%	10.1007/s00044-012-9979-z
None	NON-PROTEIN TARGET	Activity	78.66	%	10.1007/s00044-012-9979-z
None	NON-PROTEIN TARGET	Activity	115.14	mm3	10.1016/j.ejmech.2016.11.010
None	NON-PROTEIN TARGET	Activity	153.09	mm3	10.1016/j.ejmech.2016.11.010
None	NON-PROTEIN TARGET	Activity	189.83	mm3	10.1016/j.ejmech.2016.11.010
None	NON-PROTEIN TARGET	Activity	223.6	mm3	10.1016/j.ejmech.2016.11.010
None	NON-PROTEIN TARGET	Activity	271.71	mm3	10.1016/j.ejmech.2016.11.010
None	NON-PROTEIN TARGET	Activity	335.97	mm3	10.1016/j.ejmech.2016.11.010
None	NON-PROTEIN TARGET	Activity	440.75	mm3	10.1016/j.ejmech.2016.11.010
None	NON-PROTEIN TARGET	Activity	nan	None	10.1016/j.bmcl.2016.08.029
None	NON-PROTEIN TARGET	EC50	16.0	nM	10.1021/jm0202369
None	NON-PROTEIN TARGET	EC50	595.0	nM	10.1021/jm0202369
None	NON-PROTEIN TARGET	EC50	1700.0	nM	10.1021/jm0202369
None	NON-PROTEIN TARGET	Fu	0.37	None	10.1124/dmd.108.020479
None	NON-PROTEIN TARGET	GI50	15.0	nM	10.1016/j.ejmech.2016.03.002
None	NON-PROTEIN TARGET	GI50	100.0	nM	10.1016/j.bmcl.2011.07.009
None	NON-PROTEIN TARGET	Hepatotoxicity (acute)	35.0	%	10.1016/s0399-8320(04)95062-2
None	NON-PROTEIN TARGET	Hepatotoxicity (animal toxicity known)	nan	None	10.1016/s0399-8320(04)95062-2
None	NON-PROTEIN TARGET	Hepatotoxicity (benign tumour)	0.0	None	10.1016/s0399-8320(04)95062-2
None	NON-PROTEIN TARGET	Hepatotoxicity (granulomatous hepatitis)	8.0	None	10.1016/s0399-8320(04)95062-2
None	NON-PROTEIN TARGET	Hepatotoxicity (mechanism)	nan	None	10.1016/s0399-8320(04)95062-2
None	NON-PROTEIN TARGET	Hepatotoxicity (moderate)	88.0	%	10.1016/s0399-8320(04)95062-2
None	NON-PROTEIN TARGET	Hepatotoxicity (moderate)	173.0	None	10.1016/s0399-8320(04)95062-2
None	NON-PROTEIN TARGET	Hepatotoxicity (time to onset)	nan	None	10.1016/s0399-8320(04)95062-2
None	NON-PROTEIN TARGET	IC50	0.01	ug.mL-1	10.1021/np990140q
None	NON-PROTEIN TARGET	IC50	8.0	nM	10.1016/j.bmc.2006.11.017
None	NON-PROTEIN TARGET	IC50	8.3	nM	10.1021/jm9505122
None	NON-PROTEIN TARGET	IC50	9.0	nM	10.1021/jm9505122
None	NON-PROTEIN TARGET	IC50	12.0	nM	10.1021/jm200739e
None	NON-PROTEIN TARGET	IC50	12.0	nM	10.1021/jm401139z
None	NON-PROTEIN TARGET	IC50	12.0	nM	10.1021/jm8003366
None	NON-PROTEIN TARGET	IC50	13.0	nM	10.1016/j.ejmech.2016.03.032
None	NON-PROTEIN TARGET	IC50	13.0	nM	10.1021/jm00105a031
None	NON-PROTEIN TARGET	IC50	14.0	nM	10.1021/jm9505526
None	NON-PROTEIN TARGET	IC50	14.0	nM	10.1021/jm950553y
None	NON-PROTEIN TARGET	IC50	24.0	nM	10.1016/j.bmcl.2012.08.091
None	NON-PROTEIN TARGET	IC50	25.0	nM	10.1021/jm801522j
None	NON-PROTEIN TARGET	IC50	84.0	nM	10.1016/j.bmcl.2012.08.091
None	NON-PROTEIN TARGET	IC50	100.0	nM	10.1016/j.bmc.2006.11.017
None	NON-PROTEIN TARGET	IC50	106.0	nM	10.1021/jm200739e
None	NON-PROTEIN TARGET	IC50	106.0	nM	10.1021/jm401139z
None	NON-PROTEIN TARGET	IC50	106.0	nM	10.1021/jm8003366
None	NON-PROTEIN TARGET	IC50	114.0	nM	10.1021/jm200739e
None	NON-PROTEIN TARGET	IC50	114.0	nM	10.1021/jm401139z
None	NON-PROTEIN TARGET	IC50	114.0	nM	10.1021/jm8003366
None	NON-PROTEIN TARGET	IC50	211.0	nM	10.1021/jm200739e
None	NON-PROTEIN TARGET	IC50	211.0	nM	10.1021/jm401139z
None	NON-PROTEIN TARGET	IC50	211.0	nM	10.1021/jm8003366
None	NON-PROTEIN TARGET	IC50	250.0	nM	10.1016/j.ejmech.2016.11.010
None	NON-PROTEIN TARGET	IC50	340.0	nM	10.1016/j.bmcl.2012.08.091
None	NON-PROTEIN TARGET	IC50	400.0	nM	10.1021/jm00212a010
None	NON-PROTEIN TARGET	IC50	410.0	nM	10.1016/j.ejmech.2016.11.010
None	NON-PROTEIN TARGET	IC50	461.0	nM	10.1021/jm200739e
None	NON-PROTEIN TARGET	IC50	461.0	nM	10.1021/jm401139z
None	NON-PROTEIN TARGET	IC50	461.0	nM	10.1021/jm8003366
None	NON-PROTEIN TARGET	IC50	534.0	nM	10.1016/j.bmcl.2012.08.091
None	NON-PROTEIN TARGET	IC50	750.0	nM	10.1016/j.ejmech.2016.11.010
None	NON-PROTEIN TARGET	IC50	1000.0	nM	10.1021/jm401328u
None	NON-PROTEIN TARGET	IC50	1090.0	nM	10.1016/j.ejmech.2016.11.010
None	NON-PROTEIN TARGET	IC50	1500.0	nM	10.1021/jm00212a010
None	NON-PROTEIN TARGET	IC50	2200.0	nM	10.1007/s00044-012-0260-2
None	NON-PROTEIN TARGET	IC50	2400.0	nM	10.1016/j.bmc.2016.03.031
None	NON-PROTEIN TARGET	IC50	5250.0	nM	10.1016/j.bmcl.2013.07.059
None	NON-PROTEIN TARGET	IC50	9490.0	nM	10.1016/j.ejmech.2016.11.010
None	NON-PROTEIN TARGET	IC50	15800.0	nM	10.1021/acs.jnatprod.6b00109
None	NON-PROTEIN TARGET	ID50	0.003	ug ml-1	10.1021/jm00217a012
None	NON-PROTEIN TARGET	Inhibition	nan	%	10.1021/jm00212a010
None	NON-PROTEIN TARGET	LC50	100000.0	nM	10.1016/j.ejmech.2016.03.002
None	NON-PROTEIN TARGET	MTX ratio	1.0	None	10.1021/jm00344a018
None	NON-PROTEIN TARGET	Potency	39.8	nM	None
None	NON-PROTEIN TARGET	Potency	70.8	nM	None
None	NON-PROTEIN TARGET	Potency	79.4	nM	None
None	NON-PROTEIN TARGET	Potency	125.9	nM	None
None	NON-PROTEIN TARGET	Safety index	64.0	None	10.1021/jm970085n
None	NON-PROTEIN TARGET	TGI	24.65	%	10.1016/j.ejmech.2016.11.010
None	NON-PROTEIN TARGET	TGI	29.19	%	10.1016/j.ejmech.2016.11.010
None	NON-PROTEIN TARGET	TGI	32.69	%	10.1016/j.ejmech.2016.11.010
None	NON-PROTEIN TARGET	TGI	44.97	%	10.1016/j.ejmech.2016.11.010
None	NON-PROTEIN TARGET	TGI	50.65	%	10.1016/j.ejmech.2016.11.010
None	NON-PROTEIN TARGET	TGI	50.84	%	10.1016/j.ejmech.2016.11.010
None	No relevant target	LogD	-4.55	None	10.1021/jm0000564
None	No relevant target	LogD	-3.0	None	10.1021/jm001020e
None	No relevant target	LogD	-2.59	None	10.1021/jm00369a019
None	No relevant target	LogD	-2.52	None	10.1021/jm00169a014
None	No relevant target	LogD7.4	-2.52	None	10.1021/jm040760a
None	No relevant target	LogP	-2.2	None	10.1016/j.ejmech.2009.12.043
None	No relevant target	log Pe	8.5	None	10.1021/acs.jmedchem.8b01957
None	No relevant target	Peff	0.007	10'-6 cm/s	10.1021/acs.jnatprod.8b00284
None	No relevant target	Peff	0.037	10'-6 cm/s	10.1021/acs.jnatprod.8b00284
None	No relevant target	pKa	3.1	None	10.1124/dmd.110.035998
None	No relevant target	pKa	3.36	None	10.1021/jm00354a013
None	No relevant target	pKa	3.8	None	10.1021/jm0000564
None	No relevant target	pKa	4.7	None	10.1021/jm00354a013
None	No relevant target	pKa	4.7	None	10.1039/d0md00051e
None	No relevant target	pKa	5.4	None	10.1124/dmd.110.035998
None	No relevant target	pKa	5.5	None	10.1021/jm00193a021
None	No relevant target	pKa	5.6	None	10.1021/jm040760a
None	No relevant target	Solubility	10.0	ug.mL-1	10.1039/d0md00051e
None	No relevant target	Solubility	400000.0	nM	10.1021/jm061045z
None	No relevant target	Solubility	2137000.0	nM	10.1021/acs.jmedchem.7b01775
None	No relevant target	Stability	nan	%	10.1016/j.ejmech.2018.07.045
None	No relevant target	t1/2	nan	None	10.1016/j.bmc.2019.115247
None	No relevant target	T1/2	24.0	hr	10.1016/j.bmc.2019.115247
None	Phospholipidosis	Phospholipidosis	nan	None	10.1021/ci6004542
None	Phospholipidosis	Phospholipidosis	nan	None	10.1021/mp100103e
None	SNB-	IC50	1000.0	nM	10.1021/jm980477+
None	T-cell	IC50	0.0061	ug.mL-1	10.1021/jm970085n
None	Unchecked	AbsAC35_uM	0.018	uM	None
None	Unchecked	Ac50	0.2818	uM	None
None	Unchecked	Ac50	8.913	uM	None
None	Unchecked	Ac50	14.13	uM	None
None	Unchecked	Ac50	31.62	uM	None
None	Unchecked	Ac50	39.81	uM	None
None	Unchecked	AC50	160.0	nM	None
None	Unchecked	AC50	290.0	nM	None
None	Unchecked	AC50	8912.5	nM	None
None	Unchecked	AC50	14125.4	nM	None
None	Unchecked	AC50	31622.8	nM	None
None	Unchecked	AC50	39810.7	nM	None
None	Unchecked	Activity	0.32	None	10.1021/jm061027h
None	Unchecked	Activity	88.0	%	10.1021/acs.jmedchem.7b01046
None	Unchecked	Activity	nan	None	10.1016/j.bmcl.2021.128315
None	Unchecked	Activity	nan	None	10.1016/j.ejmech.2010.07.050
None	Unchecked	Activity	nan	None	10.1021/jm061475p
None	Unchecked	CC50	10000.0	nM	10.1021/acs.jmedchem.9b00775
None	Unchecked	CC50	400000.0	nM	10.1016/j.ejmech.2021.113351
None	Unchecked	Drug metabolism	87.6	%	10.1021/acs.jmedchem.7b00762
None	Unchecked	EC50	14.0	nM	10.1021/jm000130i
None	Unchecked	EC50	15.0	nM	10.1021/jm010575m
None	Unchecked	EC50	280.0	nM	10.1021/acs.jmedchem.9b00775
None	Unchecked	EC50	675.0	nM	10.1021/jm000130i
None	Unchecked	EC50	1600.0	nM	10.1021/jm000130i
None	Unchecked	Hepatotoxicity (acute)	26.0	None	10.1016/s0399-8320(04)95062-2
None	Unchecked	Hepatotoxicity (association with vascular disease)	5.0	None	10.1016/s0399-8320(04)95062-2
None	Unchecked	Hepatotoxicity (choleostasis)	2.0	None	10.1016/s0399-8320(04)95062-2
None	Unchecked	Hepatotoxicity (chronic liver disease)	45.0	None	10.1016/s0399-8320(04)95062-2
None	Unchecked	Hepatotoxicity (cirrhosis)	42.0	None	10.1016/s0399-8320(04)95062-2
None	Unchecked	Hepatotoxicity (comment)	nan	None	10.1016/s0399-8320(04)95062-2
None	Unchecked	Hepatotoxicity (cytolytic)	21.0	None	10.1016/s0399-8320(04)95062-2
None	Unchecked	Hepatotoxicity (malignant tumour)	8.0	None	10.1016/s0399-8320(04)95062-2
None	Unchecked	Hepatotoxicity (severe hepatitis)	5.0	None	10.1016/s0399-8320(04)95062-2
None	Unchecked	Hepatotoxicity (steatosis)	16.0	None	10.1016/s0399-8320(04)95062-2
None	Unchecked	Hepatotoxicity (successful reintroduction)	nan	None	10.1016/s0399-8320(04)95062-2
None	Unchecked	IC50	0.0125	ug.mL-1	10.1021/jm970085n
None	Unchecked	IC50	0.038	nM	10.1016/j.bmc.2021.116577
None	Unchecked	IC50	0.22	nM	10.1021/jm400086g
None	Unchecked	IC50	1.0	nM	None
None	Unchecked	IC50	4.5	nM	10.1021/jm950793d
None	Unchecked	IC50	5.1	nM	10.1021/jm400086g
None	Unchecked	IC50	6.6	nM	10.1016/j.bmcl.2017.02.018
None	Unchecked	IC50	6.6	nM	10.1021/jm058276a
None	Unchecked	IC50	6.6	nM	10.1021/jm070165j
None	Unchecked	IC50	8.8	nM	10.1021/jm701052u
None	Unchecked	IC50	9.0	nM	10.1021/jm00368a023
None	Unchecked	IC50	9.0	nM	10.1021/jm00380a011
None	Unchecked	IC50	10.0	nM	10.1021/jm00126a023
None	Unchecked	IC50	11.6	nM	None
None	Unchecked	IC50	12.0	nM	10.1016/j.bmc.2020.115544
None	Unchecked	IC50	13.0	nM	10.1021/jm00105a036
None	Unchecked	IC50	13.0	nM	10.1021/jm00123a001
None	Unchecked	IC50	14.0	nM	10.1021/acs.jmedchem.1c01569
None	Unchecked	IC50	15.0	nM	10.1021/jm00380a011
None	Unchecked	IC50	15.0	nM	10.1021/jm980477+
None	Unchecked	IC50	18.0	nM	10.1021/jm00380a011
None	Unchecked	IC50	19.0	nM	10.1021/jm9011142
None	Unchecked	IC50	20.0	nM	10.1021/jm950793d
None	Unchecked	IC50	24.0	nM	10.1021/jm00106a016
None	Unchecked	IC50	25.0	nM	10.1021/jm00380a011
None	Unchecked	IC50	26.0	nM	10.1021/jm00193a021
None	Unchecked	IC50	26.5	nM	None
None	Unchecked	IC50	30.0	nM	10.1021/jm950793d
None	Unchecked	IC50	33.0	nM	10.1021/jm701052u
None	Unchecked	IC50	61.0	nM	10.1021/jm9605288
None	Unchecked	IC50	68.6	nM	10.1128/aac.00384-08
None	Unchecked	IC50	106.0	nM	10.1016/j.bmc.2020.115544
None	Unchecked	IC50	114.0	nM	10.1016/j.bmc.2020.115544
None	Unchecked	IC50	114.0	nM	10.1021/acs.jmedchem.6b00594
None	Unchecked	IC50	114.0	nM	10.1021/acs.jmedchem.7b01708
None	Unchecked	IC50	121.0	nM	10.1016/j.bmc.2020.115544
None	Unchecked	IC50	216.0	nM	10.1016/j.bmc.2020.115544
None	Unchecked	IC50	600.0	nM	10.1021/jm8006933
None	Unchecked	IC50	1000.0	nM	10.1021/acs.jmedchem.7b01708
None	Unchecked	IC50	1800.0	nM	10.1021/acsmedchemlett.0c00105
None	Unchecked	IC50	2900.0	nM	10.1021/acsmedchemlett.0c00105
None	Unchecked	IC50	5480.0	nM	10.1016/j.bmcl.2020.127754
None	Unchecked	IC50	10000.0	nM	None
None	Unchecked	IC50	20000.0	nM	None
None	Unchecked	IC50	23000.0	nM	10.1021/jm061027h
None	Unchecked	IC50	60000.0	nM	10.1021/jm00358a030
None	Unchecked	IC50	90000.0	nM	10.1016/j.bmc.2009.11.029
None	Unchecked	IC50	100000.0	nM	10.1016/j.ejmech.2016.03.002
None	Unchecked	IC50	149880.0	nM	10.1016/j.ejmech.2019.111587
None	Unchecked	IC50	150000.0	nM	10.1021/jm00358a030
None	Unchecked	IC50	nan	None	10.1021/jm701052u
None	Unchecked	IC50	nan	None	None
None	Unchecked	ID50	0.03	uM	10.1021/jm00083a017
None	Unchecked	IFI	0.0	%	10.1038/nature09107
None	Unchecked	IFI	0.74	%	10.1038/nature09107
None	Unchecked	IFI	1.46	%	10.1038/nature09107
None	Unchecked	ILS	78.0	%	10.1021/jm00349a024
None	Unchecked	ILS	82.0	%	10.1021/jm00349a024
None	Unchecked	Inhibition	190.0	%	10.1021/jm00369a024
None	Unchecked	Inhibition	nan	%	10.1016/j.bmcl.2021.128315
None	Unchecked	Inhibition	nan	%	10.1016/j.ejmech.2017.01.022
None	Unchecked	Inhibition	nan	%	10.1038/nchembio873
None	Unchecked	Inhibition	nan	%	10.1128/aac.00384-08
None	Unchecked	Kd	10.0	None	10.1021/jm950793d
None	Unchecked	Kd	nan	None	10.1021/jm950793d
None	Unchecked	Ki	0.027	None	10.1021/jm950793d
None	Unchecked	Ki	0.35	nM	10.1016/j.bmc.2019.04.032
None	Unchecked	Ki	4.4	None	10.1021/jm950793d
None	Unchecked	Ki	10.0	nM	10.1021/acsmedchemlett.0c00393
None	Unchecked	Ki	152.0	nM	10.1021/jm901059x
None	Unchecked	Ki	5190.0	nM	10.1016/j.bmc.2021.116093
None	Unchecked	Ki	500000.0	nM	10.1021/acsmedchemlett.0c00393
None	Unchecked	Ki	nan	None	None
None	Unchecked	Km	3420.0	nM	10.1021/jm00352a026
None	Unchecked	Km	4840.0	nM	10.1021/jm00366a012
None	Unchecked	Km	11400.0	nM	10.1021/jm00349a024
None	Unchecked	Max_Activity	26.0	uM	None
None	Unchecked	MST	17.8	day	10.1021/jm00349a024
None	Unchecked	MST	21.4	day	10.1021/jm00349a024
None	Unchecked	Potency	39.8	nM	None
None	Unchecked	Potency	46.1	nM	None
None	Unchecked	Potency	141.3	nM	None
None	Unchecked	Potency	145.8	nM	None
None	Unchecked	Potency	631.0	nM	None
None	Unchecked	Potency	891.3	nM	None
None	Unchecked	Potency	1000.0	nM	None
None	Unchecked	Potency	3162.3	nM	None
None	Unchecked	Potency	5623.4	nM	None
None	Unchecked	Potency	11220.2	nM	None
None	Unchecked	Potency	15848.9	nM	None
None	Unchecked	Potency	28183.8	nM	None
None	Unchecked	Ratio	1.0	None	10.1021/jm00105a035
None	Unchecked	Ratio	1.0	None	10.1021/jm00193a021
None	Unchecked	Ratio	1.0	None	10.1021/jm0202369
None	Unchecked	Ratio	2.1	None	10.1021/jm00040a008
None	Unchecked	Ratio	3.7	None	10.1021/jm0202369
None	Unchecked	Ratio	4.3	None	10.1016/0960-894X(96)00053-4
None	Unchecked	Ratio	10.0	None	10.1021/jm901059x
None	Unchecked	Ratio	20.0	None	10.1021/jm0202369
None	Unchecked	Ratio	243.0	None	10.1021/jm00040a008
None	Unchecked	Ratio	1000.0	None	10.1021/jm901059x
None	Unchecked	Ratio	11714.0	None	10.1016/j.bmc.2019.04.032
None	Unchecked	Ratio IC50	0.061	None	10.1021/acs.jmedchem.8b01754
None	Unchecked	Ratio IC50	0.066	None	10.1021/acsmedchemlett.6b00328
None	Unchecked	Ratio IC50	0.194	None	10.1016/j.bmc.2019.02.053
None	Unchecked	Ratio IC50	0.194	None	10.1021/acsmedchemlett.5b00367
None	Unchecked	Ratio IC50	0.2	None	10.1016/j.ejmech.2017.12.017
None	Unchecked	Ratio IC50	0.34	None	10.1021/jm400086g
None	Unchecked	Ratio IC50	0.6	None	10.1021/jm701052u
None	Unchecked	Ratio IC50	0.6	None	10.1021/jm900490a
None	Unchecked	Ratio IC50	1.6	None	10.1021/acsmedchemlett.0c00105
None	Unchecked	Ratio IC50	1.9	None	10.1021/acsmedchemlett.0c00105
None	Unchecked	Ratio IC50	1.9	None	10.1021/jm400086g
None	Unchecked	Ratio IC50	2.0	None	10.1021/jm800244v
None	Unchecked	Ratio IC50	2.2	None	10.1021/acsmedchemlett.0c00105
None	Unchecked	Ratio IC50	3.0	None	10.1016/j.bmc.2011.03.067
None	Unchecked	Ratio IC50	3.3	None	10.1021/jm800244v
None	Unchecked	Ratio IC50	3.33	None	10.1021/jm070165j
None	Unchecked	Ratio IC50	4.0	None	10.1016/j.bmcl.2012.08.091
None	Unchecked	Ratio IC50	4.0	None	10.1021/jm00212a010
None	Unchecked	Ratio IC50	11.0	None	10.1021/jm400086g
None	Unchecked	Ratio IC50	22.0	None	10.1016/j.bmcl.2012.08.091
None	Unchecked	Ratio Ki	0.0	None	10.1021/jm300563f
None	Unchecked	Ratio Ki	3.0	None	10.1021/jm300563f
None	Unchecked	Ratio pKi	0.18	None	10.1074/jbc.m703467200
None	Unchecked	Relative growth	12.0	None	10.1021/jm000200l
None	Unchecked	Relative growth	14.5	None	10.1021/jm000200l
None	Unchecked	Relative growth	15.5	None	10.1021/jm000200l
None	Unchecked	Relative growth	80.0	None	10.1021/jm000200l
None	Unchecked	Relative influx	1.0	None	10.1021/jm00080a017
None	Unchecked	Relative influx	1.0	None	10.1021/jm00164a033
None	Unchecked	Resistance	44000.0	None	10.1021/jm00391a031
None	Unchecked	Safety index	14.1	None	10.1021/jm970085n
None	Unchecked	Selectivity	1.0	None	10.1021/jm00024a001
None	Unchecked	Selectivity	4.7	None	10.1016/s0960-894x(99)00213-9
None	Unchecked	Selectivity Index	1.0	None	10.1016/j.ejmech.2021.113351
None	Unchecked	Selectivity ratio	0.014	None	10.1021/jm9705420
None	Unchecked	Selectivity ratio	0.21	None	10.1021/jm00012a016
None	Unchecked	Selectivity ratio	0.21	None	10.1021/jm9705420
None	Unchecked	Selectivity ratio	0.7	None	10.1021/jm950786p
None	Unchecked	Selectivity ratio	1.4	None	10.1021/jm950786p
None	Unchecked	Selectivity ratio	3.0	None	10.1021/jm00012a016
None	Unchecked	Selectivity ratio	17.0	None	10.1021/jm950786p
None	Unchecked	Vmax	0.134	min-1	10.1021/jm00366a012
None	Unchecked	Vmax / Km	4.3	None	10.1016/s0960-894x(98)00683-0
None	Unchecked	Weight at term	24.1	g	10.1021/jm00349a024
None	Unchecked	Weight at term	24.4	g	10.1021/jm00349a024

Metabolism Information

AKRT ID	Reaction	Reaction Link ID
AKRT010466	CN(Cc1cnc2nc(=N)[nH]c(N)c2n1)c1ccc(C(=O)NC(CCC(=O)O)C(=O)NC(Cc2ccccc2)C(=O)O)cc1>>CN(Cc1cnc2nc(=N)[nH]c(N)c2n1)c1ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)cc1	enzymemap_67456
AKRT010468	CN(Cc1cnc2nc(=N)[nH]c(N)c2n1)c1ccc(C(=O)NC(CCC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(=O)O)cc1>>CN(Cc1cnc2nc(=N)[nH]c(N)c2n1)c1ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)cc1	enzymemap_67473
AKRT010471	CN(Cc1cnc2nc(=N)[nH]c(N)c2n1)c1ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc2cccc3ccccc23)C(=O)O)cc1>>CN(Cc1cnc2nc(=N)[nH]c(N)c2n1)c1ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)cc1	enzymemap_67472
AKRT010472	CN(Cc1cnc2nc(=N)[nH]c(N)c2n1)c1ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)cc1.N[C@@H](CCC(=O)O)C(=O)O>>CN(Cc1cnc2nc(=N)[nH]c(N)c2n1)c1ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)O)cc1	enzymemap_90363
AKRT010473	CN(Cc1cnc2nc(=N)[nH]c(N)c2n1)c1ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)cc1.N[C@H](C(=O)O)C(F)(F)CC(=O)O>>CN(Cc1cnc2nc(=N)[nH]c(N)c2n1)c1ccc(C(=O)N[C@@H](CCC(=O)N[C@H](C(=O)O)C(F)(F)CC(=O)O)C(=O)O)cc1	enzymemap_90461
AKRT010474	CN(Cc1cnc2nc(=N)[nH]c(N)c2n1)c1ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)cc1>>CN(Cc1cnc2nc(=N)[nH]c(N)c2n1)c1ccc(C(=O)O)cc1	enzymemap_67545
AKRT010475	CN(Cc1cnc2nc(=N)[nH]c(N)c2n1)c1ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)cc1>>N[C@@H](CCC(=O)O)C(=O)O	enzymemap_67545
AKRT010477	CN(Cc1cnc2nc(N)nc(N)c2n1)c1ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc2cccc3ccccc23)C(=O)O)cc1>>CN(Cc1cnc2nc(N)nc(N)c2n1)c1ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)cc1	enzymemap_67472
AKRT010478	CN(Cc1cnc2nc(N)nc(N)c2n1)c1ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(=O)O)cc1>>CN(Cc1cnc2nc(N)nc(N)c2n1)c1ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)cc1	enzymemap_67473
AKRT010480	CN(Cc1cnc2nc(N)nc(N)c2n1)c1ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)cc1.N[C@@H](CCC(=O)O)C(=O)O>>CN(Cc1cnc2nc(N)nc(N)c2n1)c1ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)O)cc1	enzymemap_90363
AKRT010481	CN(Cc1cnc2nc(N)nc(N)c2n1)c1ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)cc1>>CN(Cc1cnc2nc(=N)[nH]c(N)c2n1)c1ccc(C(=O)O)cc1	MNXR131606
AKRT010482	CN(Cc1cnc2nc(N)nc(N)c2n1)c1ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)cc1>>CN(Cc1cnc2nc(N)nc(N)c2n1)c1ccc(C(=O)O)cc1	enzymemap_67545
AKRT010483	CN(Cc1cnc2nc(N)nc(N)c2n1)c1ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)cc1>>N[C@@H](CCC(=O)O)C(=O)O	MNXR131606