Lucidamine A
AlkaPlorer ID: AK016904
Synonym: None
IUPAC Name: 1-[(6S)-2,3-dihydroxy-7,8-dimethoxy-5-methyl-6H-benzo[c]phenanthridin-6-yl]propan-2-one
Structure
SMILES: COC1=CC=C2C3=CC=C4C=C(O)C(O)=CC4=C3N(C)[C@@H](CC(C)=O)C2=C1OC
InChI: InChI=1S/C23H23NO5/c1-12(25)9-17-21-14(7-8-20(28-3)23(21)29-4)15-6-5-13-10-18(26)19(27)11-16(13)22(15)24(17)2/h5-8,10-11,17,26-27H,9H2,1-4H3/t17-/m0/s1
InChIKey: OZFFCUIRRDOAHH-KRWDZBQOSA-N
Reference
Trypanocidal and Antileishmanial Dihydrochelerythrine Derivatives from <i>Garcinia lucida</i>
PubChem CID: 23656474
LOTUS: LTS0018264
NPASS: NPC17677
Source
| Species | Genus | Family | Order | Class | Phylum | Kingdom | Domain |
|---|---|---|---|---|---|---|---|
| Garcinia lucida | Garcinia | Clusiaceae | Malpighiales | Magnoliopsida | Streptophyta | Viridiplantae | Eukaryota |
Properties Information
Molecule Weight: 393.4390000000002
TPSA？: 79.23
MolLogP？: 4.405200000000004
Number of H-Donors: 2
Number of H-Acceptors: 6
RingCount: 4
Activities Information
| Organism | Target Name | Standard Type | Standard Value | Standard Units | doi |
|---|---|---|---|---|---|
| Chlorocebus sabaeus | Vero | IC50 | 11600.0 | nM | 10.1021/np0702281 |
| Leishmania donovani | Leishmania donovani | Activity | nan | None | 10.1021/np0702281 |
| Leishmania donovani | Leishmania donovani | IC50 | 10800.0 | nM | 10.1021/np0702281 |
| Leishmania donovani | Leishmania donovani | Inhibition | 23.0 | % | 10.1021/np0702281 |
| Leishmania donovani | Leishmania donovani | Inhibition | 76.0 | % | 10.1021/np0702281 |
| Leishmania donovani | Leishmania donovani | Inhibition | 100.0 | % | 10.1021/np0702281 |
| Mus musculus | RAW | Activity | nan | None | 10.1021/np0702281 |
| Trypanosoma brucei brucei | Trypanosoma brucei brucei | IC50 | 14100.0 | nM | 10.1021/np0702281 |