Norisoboldine
AlkaPlorer ID: AK016987
Synonym: 'Norisoboldine', '', '(+)-Norisoboldine', '(S)-(+)-Laurelliptine', '(+)-N-Norisoboldine', '(+)-Laurelliptine', 'Laurelliptine'
IUPAC Name: (6aS)-2,10-dimethoxy-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-1,9-diol
Structure
SMILES: COC1=CC2=C(C=C1O)C[C@@H]1NCCC3=CC(OC)=C(O)C2=C31
InChI: InChI=1S/C18H19NO4/c1-22-14-8-11-10(6-13(14)20)5-12-16-9(3-4-19-12)7-15(23-2)18(21)17(11)16/h6-8,12,19-21H,3-5H2,1-2H3/t12-/m0/s1
InChIKey: HORZNQYQXBFWNZ-LBPRGKRZSA-N
Reference
Aporphine alkaloids from Ocotea caesia
PubChem CID: 14539911
LOTUS: LTS0266234
SuperNatural Ⅲ: SN0131363-02
Source
| Species | Genus | Family | Order | Class | Phylum | Kingdom | Domain |
|---|---|---|---|---|---|---|---|
| Stephania cephalantha | Stephania | Menispermaceae | Ranunculales | Magnoliopsida | Streptophyta | Viridiplantae | Eukaryota |
Properties Information
Molecule Weight: 313.35300000000007
TPSA？: 70.95
MolLogP？: 2.524900000000001
Number of H-Donors: 3
Number of H-Acceptors: 5
RingCount: 4
Activities Information
| Organism | Target Name | Standard Type | Standard Value | Standard Units | doi |
|---|---|---|---|---|---|
| Mus musculus | EL4 | Activity | nan | None | 10.1016/j.bmcl.2021.127844 |
| Mus musculus | Mus musculus | Activity | 6.58 | % | 10.1016/j.bmcl.2021.127844 |
| Mus musculus | Mus musculus | Activity | 7.41 | % | 10.1016/j.bmcl.2021.127844 |
| Mus musculus | Mus musculus | Activity | 9.8 | % | 10.1016/j.bmcl.2021.127844 |
| Mus musculus | Mus musculus | Activity | 12.25 | % | 10.1016/j.bmcl.2021.127844 |
| Mus musculus | Mus musculus | Activity | 14.89 | % | 10.1016/j.bmcl.2021.127844 |
| Mus musculus | Mus musculus | Activity | 15.87 | % | 10.1016/j.bmcl.2021.127844 |
| Mus musculus | Mus musculus | Activity | nan | None | 10.1016/j.bmcl.2021.127844 |
| None | T-cell | Activity | 24.4 | % | 10.1016/j.bmcl.2021.127844 |
| None | T-cell | Activity | 31.8 | % | 10.1016/j.bmcl.2021.127844 |
| None | T-cell | Activity | 44.2 | % | 10.1016/j.bmcl.2021.127844 |
| None | T-cell | Activity | nan | None | 10.1016/j.bmcl.2021.127844 |