mayamycin
AlkaPlorer ID: AK017059
Synonym: 'Mayamycin'
IUPAC Name: 1,6,8-trihydroxy-5-[(2R,4R,5S,6R)-5-(hydroxymethyl)-6-methyl-4-(methylamino)oxan-2-yl]-3-methylbenzo[a]anthracene-7,12-dione
Structure
SMILES: CN[C@@H]1C[C@H](C2=C(O)C3=C(C(=O)C4=CC=CC(O)=C4C3=O)C3=C(O)C=C(C)C=C23)O[C@H](C)[C@@H]1CO
InChI: InChI=1S/C27H27NO7/c1-11-7-14-20(18(31)8-11)23-24(26(33)21-13(25(23)32)5-4-6-17(21)30)27(34)22(14)19-9-16(28-3)15(10-29)12(2)35-19/h4-8,12,15-16,19,28-31,34H,9-10H2,1-3H3/t12-,15+,16-,19-/m1/s1
InChIKey: AQNPJKKYGQVMOS-BMHLXIAXSA-N
Source
| Species | Genus | Family | Order | Class | Phylum | Kingdom | Domain |
|---|---|---|---|---|---|---|---|
| None | None | Streptomycetaceae | Kitasatosporales | Actinomycetes | Actinomycetota | None | Bacteria |
Properties Information
Molecule Weight: 477.51300000000026
TPSA？: 136.32
MolLogP？: 3.0868200000000026
Number of H-Donors: 5
Number of H-Acceptors: 8
RingCount: 5
Activities Information
| Organism | Target Name | Standard Type | Standard Value | Standard Units | doi |
|---|---|---|---|---|---|
| Bacillus subtilis | Bacillus subtilis | IC50 | 8000.0 | nM | 10.1021/np100135b |
| Brevibacterium epidermidis | Brevibacterium epidermidis | IC50 | 7450.0 | nM | 10.1021/np100135b |
| Cutibacterium acnes | Cutibacterium acnes | IC50 | 31200.0 | nM | 10.1021/np100135b |
| Dermabacter hominis | Dermabacter hominis | IC50 | 8400.0 | nM | 10.1021/np100135b |
| Homo sapiens | HepG2 | IC50 | 200.0 | nM | 10.1021/np100135b |
| Homo sapiens | HT-29 | IC50 | 300.0 | nM | 10.1021/np100135b |
| Klebsiella pneumoniae | Klebsiella pneumoniae | IC50 | 2500.0 | nM | 10.1021/np100135b |
| Mammaliicoccus lentus | Mammaliicoccus lentus | IC50 | 8000.0 | nM | 10.1021/np100135b |
| Pseudomonas aeruginosa | Pseudomonas aeruginosa | IC50 | 2500.0 | nM | 10.1021/np100135b |
| Staphylococcus aureus | Staphylococcus aureus | IC50 | 1250.0 | nM | 10.1021/np100135b |
| Staphylococcus aureus | Staphylococcus aureus | IC50 | 2500.0 | nM | 10.1021/np100135b |
| Staphylococcus epidermidis | Staphylococcus epidermidis | IC50 | 310.0 | nM | 10.1021/np100135b |
| Xanthomonas campestris | Xanthomonas campestris | IC50 | 30000.0 | nM | 10.1021/np100135b |
| None | NON-PROTEIN TARGET | IC50 | 130.0 | nM | 10.1021/np100135b |
| None | NON-PROTEIN TARGET | IC50 | 150.0 | nM | 10.1021/np100135b |
| None | NON-PROTEIN TARGET | IC50 | 160.0 | nM | 10.1021/np100135b |
| None | NON-PROTEIN TARGET | IC50 | 200.0 | nM | 10.1021/np100135b |
| None | NON-PROTEIN TARGET | IC50 | 290.0 | nM | 10.1021/np100135b |
| None | NON-PROTEIN TARGET | IC50 | 330.0 | nM | 10.1021/np100135b |