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Periglaucine C

AlkaPlorer ID: AK017134

Synonym: None

IUPAC Name: (1R,11R,13S,14S,15R)-14,15-dimethoxy-20-methyl-5,7,21-trioxa-20-azahexacyclo[11.4.3.111,14.01,13.02,10.04,8]henicosa-2,4(8),9-triene-16,19-dione

Structure

SMILES: CO[C@@H]1C(=O)C[C@]23CC(=O)N(C)[C@@]24C[C@@H](O[C@]14OC)C1=CC2=C(C=C13)OCO2

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InChI: InChI=1S/C20H21NO7/c1-21-16(23)8-18-6-12(22)17(24-2)20(25-3)19(18,21)7-15(28-20)10-4-13-14(5-11(10)18)27-9-26-13/h4-5,15,17H,6-9H2,1-3H3/t15-,17-,18-,19+,20-/m1/s1

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InChIKey: JCBUXRPOTHJGDK-RACLHMPKSA-N

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Source

Species Genus Family Order Class Phylum Kingdom Domain
Pericampylus glaucus Pericampylus Menispermaceae Ranunculales Magnoliopsida Streptophyta Viridiplantae Eukaryota

Properties Information

Molecule Weight: 387.3880000000002

TPSA？: 83.53000000000002

MolLogP？: 1.0595

Number of H-Donors: 0

Number of H-Acceptors: 7

RingCount: 6

Activities Information

Organism Target Name Standard Type Standard Value Standard Units doi
Hepatitis B virus Hepatitis B virus IC50 1720000.0 nM 10.1021/np070479+
Hepatitis B virus Hepatitis B virus IC50 3690000.0 nM 10.1021/np070479+
Homo sapiens C8166 CC50 516000.0 nM 10.1021/np070479+
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 162500.0 nM 10.1021/np070479+
None ADMET CC50 2360000.0 nM 10.1021/np070479+
None Unchecked Ratio CC50/EC50 3.29 None 10.1021/np070479+
None Unchecked Ratio CC50/IC50 1.0 None 10.1021/np070479+
None Unchecked Ratio CC50/IC50 1.37 None 10.1021/np070479+

Metabolism Information