Patupilone
AlkaPlorer ID: AK017211
Synonym: None
IUPAC Name: (1S,3S,7S,10R,11S,12S,16R)-7,11-dihydroxy-8,8,10,12,16-pentamethyl-3-[(E)-1-(2-methyl-1,3-thiazol-4-yl)prop-1-en-2-yl]-4,17-dioxabicyclo[14.1.0]heptadecane-5,9-dione
Structure
SMILES: C/C(=C\C1=CSC(C)=N1)[C@@H]1C[C@@H]2O[C@]2(C)CCC[C@H](C)[C@H](O)[C@@H](C)C(=O)C(C)(C)[C@@H](O)CC(=O)O1
InChI: InChI=1S/C27H41NO6S/c1-15-9-8-10-27(7)22(34-27)12-20(16(2)11-19-14-35-18(4)28-19)33-23(30)13-21(29)26(5,6)25(32)17(3)24(15)31/h11,14-15,17,20-22,24,29,31H,8-10,12-13H2,1-7H3/b16-11+/t15-,17+,20-,21-,22-,24-,27+/m0/s1
InChIKey: QXRSDHAAWVKZLJ-PVYNADRNSA-N
Source
| Species | Genus | Family | Order | Class | Phylum | Kingdom | Domain |
|---|---|---|---|---|---|---|---|
| Apis cerana | Apis | Apidae | Hymenoptera | Insecta | Arthropoda | Metazoa | Eukaryota |
Properties Information
Molecule Weight: 507.6930000000003
TPSA？: 109.25
MolLogP？: 4.477520000000005
Number of H-Donors: 2
Number of H-Acceptors: 8
RingCount: 3
Activities Information
| Organism | Target Name | Standard Type | Standard Value | Standard Units | doi |
|---|---|---|---|---|---|
| Homo sapiens | 1A9 | IC50 | 0.06 | nM | 10.1021/acs.jmedchem.7b00315 |
| Homo sapiens | 1A9 | IC50 | 0.13 | nM | 10.1021/jm050524f |
| Homo sapiens | 1A9/ptx-10 | IC50 | 1.0 | nM | 10.1021/jm050524f |
| Homo sapiens | 1A9/ptx-22 | IC50 | 0.31 | nM | 10.1021/jm050524f |
| Homo sapiens | 23132-87 | IC50 | 3.665 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | 5637 | IC50 | 0.6382 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | 639-V | IC50 | 0.218 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | 647-V | IC50 | 2.416 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | 697 | IC50 | 1.781 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | 769-P | IC50 | 0.7534 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | 786-0 | GI50 | 0.1 | nM | None |
| Homo sapiens | 786-0 | IC50 | 0.1104 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | 8305C | IC50 | 2.324 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | 8505C | IC50 | 0.4507 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | 8-MG-BA | IC50 | 4.779 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | A101D | IC50 | 0.856 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | A 172 | IC50 | 1.924 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | A204 | IC50 | 3.12 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | A2058 | IC50 | 0.6008 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | A253 cell line | IC50 | 10.31 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | A2780 | EC50 | 4.0 | nM | 10.1016/j.bmcl.2019.04.035 |
| Homo sapiens | A2780 | EC50 | 5.2 | nM | 10.1016/j.bmcl.2019.04.035 |
| Homo sapiens | A2780 | IC50 | 2.09 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | A-375 | IC50 | 0.04997 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | A388 | IC50 | 0.9397 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | A3-KAW | IC50 | 6.057 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | A-427 | IC50 | 0.8277 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | A-431 | IC50 | 0.009861 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | A-431 | IC50 | 0.073 | nM | 10.1021/acs.jnatprod.7b00064 |
| Homo sapiens | A-431 | IC50 | 0.079 | nM | 10.1021/acs.jnatprod.9b00604 |
| Homo sapiens | A-431 | IC50 | 67000.0 | nM | 10.1021/acs.jnatprod.1c00975 |
| Homo sapiens | A498 | GI50 | 0.1 | nM | None |
| Homo sapiens | A498 | IC50 | 61.3 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | A4-Fuk | IC50 | 1.09 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | A549 | GI50 | 0.1 | nM | None |
| Homo sapiens | A549 | GI50 | 0.7 | nM | 10.1021/acsmedchemlett.7b00131 |
| Homo sapiens | A549 | IC50 | 0.069 | nM | 10.1021/acs.jnatprod.9b00604 |
| Homo sapiens | A549 | IC50 | 0.15 | nM | 10.1021/acs.jnatprod.7b00064 |
| Homo sapiens | A549 | IC50 | 4.0 | nM | 10.1021/acs.jnatprod.8b00708 |
| Homo sapiens | A549 | IC50 | 88000.0 | nM | 10.1021/acs.jnatprod.1c00975 |
| Homo sapiens | A673 | IC50 | 2.48 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | A704 | IC50 | 14.6 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | ABC-1 | IC50 | 1.675 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | ACHN | GI50 | 0.1 | nM | None |
| Homo sapiens | ACHN | IC50 | 0.7486 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | ACN | IC50 | 1.068 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | AGS | IC50 | 2.577 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | ALL-PO | IC50 | 1.469 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | AM-38 | IC50 | 7.564 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | AN3-CA | IC50 | 0.4522 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | ARH-77 | IC50 | 6.13 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | ASPC1 | IC50 | 143.67 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | ATN-1 | IC50 | 3.465 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | AU565 | IC50 | 4.095 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | BB30-HNC | IC50 | 0.2008 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | BB49-HNC | IC50 | 146.92 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | BB65-RCC | IC50 | 0.6306 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | BC-3 | IC50 | 8.389 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | BCPAP | IC50 | 0.5813 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | BE-13 | IC50 | 7.296 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | Becker | IC50 | 2.857 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | Bel-7402 | IC50 | 0.9 | nM | 10.1021/jm200848t |
| Homo sapiens | BEN | IC50 | 20.57 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | BFTC-905 | IC50 | 0.04994 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | BFTC-909 | IC50 | 1.557 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | BHT-101 | IC50 | 1.519 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | BHY | IC50 | 0.1954 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | BL-41 | IC50 | 1.353 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | BL-70 | IC50 | 2.16 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | BOKU | IC50 | 251.89 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | BPH-1 | IC50 | 0.5205 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | BT-20 | IC50 | 5.097 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | BT-474 | IC50 | 13.17 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | BT-549 | GI50 | 0.1 | nM | None |
| Homo sapiens | BV-173 | IC50 | 190.2 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | BXPC-3 | IC50 | 1.737 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | C2BBe1 | IC50 | 48.29 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | C32 | IC50 | 1912.59 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | C-33-A | IC50 | 3.272 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | C3A | IC50 | 3.415 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | C-4-II | IC50 | 5.367 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | C8166 | IC50 | 31.69 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | CA46 | IC50 | 9.61 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | Ca9-22 | IC50 | 1.131 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | CAKI-1 | GI50 | 0.1 | nM | None |
| Homo sapiens | CAKI-1 | IC50 | 17.34 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | CAL-120 | IC50 | 10.12 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | CAL-12T | IC50 | 0.2389 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | CAL-148 | IC50 | 6.258 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | CAL-27 | IC50 | 1.387 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | CAL-33 | IC50 | 1.515 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | CAL-39 | IC50 | 0.4113 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | CAL-51 | IC50 | 1.659 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | CAL-54 | IC50 | 170.76 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | CAL-62 | IC50 | 0.8749 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | CAL-72 | IC50 | 123.19 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | CAL-85-1 | IC50 | 0.6617 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | Calu-1 | IC50 | 10.61 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | Calu-3 | IC50 | 1.683 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | Calu-6 | IC50 | 7.137 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | CAMA-1 | IC50 | 12.93 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | Caov-3 cell line | IC50 | 13.87 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | CAPAN-1 | IC50 | 4.005 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | Capan-2 | IC50 | 30.05 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | CaR-1 | IC50 | 34.29 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | CAS-1 | IC50 | 24.47 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | Ca-Ski | IC50 | 3.851 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | CCF-STTG1 | IC50 | 5.826 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | CCRF-CEM | GI50 | 0.1 | nM | None |
| Homo sapiens | CCRF-CEM | IC50 | 2.94 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | CESS | IC50 | 3.379 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | CGTH-W-1 | IC50 | 2.803 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | ChaGo-K-1 | IC50 | 9.612 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | CHL-1 | IC50 | 0.979 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | CHP-126 | IC50 | 58.34 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | CHP-212 | IC50 | 5.828 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | CMK | IC50 | 1.326 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | COLO 205 | GI50 | 0.1 | nM | None |
| Homo sapiens | COLO 205 | IC50 | 0.8015 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | COLO-320-HSR | IC50 | 5.207 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | COLO-668 | IC50 | 39.75 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | COLO-678 | IC50 | 1253.12 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | COLO-679 | IC50 | 0.3939 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | COLO-680N | IC50 | 7.165 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | COLO-684 | IC50 | 6.97 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | COLO-741 | IC50 | 2.72 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | COLO-792 | IC50 | 467.37 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | COLO-800 | IC50 | 32.53 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | COLO-824 | IC50 | 23.31 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | COLO-829 | IC50 | 575.7 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | COR-L105 | IC50 | 9.538 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | COR-L23 | IC50 | 1.353 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | COR-L279 | IC50 | 9.273 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | COR-L88 | IC50 | 118.98 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | CP50-MEL-B | IC50 | 19.03 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | CP66-MEL | IC50 | 11.67 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | CPC-N | IC50 | 10.69 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | CTB-1 | IC50 | 8.305 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | CTV-1 | IC50 | 5.16 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | CW-2 | IC50 | 7006.87 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | CWR22R | IC50 | 8.411 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | D-263MG | IC50 | 35.8 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | D283 Med | IC50 | 186.47 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | D-392MG | IC50 | 115.01 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | D-502MG | IC50 | 111.01 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | D-542MG | IC50 | 1883.62 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | Daoy | IC50 | 0.02733 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | Daudi | IC50 | 24.77 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | DB | IC50 | 7.109 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | DBTRG-05MG | IC50 | 5.855 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | DEL | IC50 | 4.293 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | Detroit 562 | IC50 | 1.404 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | DG-75 | IC50 | 52.79 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | DJM-1 | IC50 | 3.133 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | DK-MG | IC50 | 35.82 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | DMS-114 | IC50 | 64.83 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | DMS-153 | IC50 | 29.33 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | DMS-273 | IC50 | 1.62 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | DMS-53 | IC50 | 1061.03 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | DMS-79 | IC50 | 562.93 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | DOHH-2 | IC50 | 8.37 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | DOK | IC50 | 955.06 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | DoTc2-4510 | IC50 | 0.8462 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | DSH1 | IC50 | 298.63 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | DU-145 | GI50 | 0.1 | nM | None |
| Homo sapiens | DU-145 | IC50 | 0.7212 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | DU-4475 | IC50 | 2.382 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | DV-90 | IC50 | 14.64 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | EB2 | IC50 | 3.693 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | EB-3 | IC50 | 97.89 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | ECC4 | IC50 | 57.36 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | EC-GI-10 | IC50 | 63.71 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | EFE-184 | IC50 | 115.95 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | EFM-19 | IC50 | 10.61 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | EFO-21 | IC50 | 9.824 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | EFO-27 | IC50 | 1.691 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | EGI-1 | IC50 | 73.4 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | EHEB | IC50 | 28.92 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | EKVX | GI50 | 0.1 | nM | None |
| Homo sapiens | EKVX | IC50 | 33.69 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | EM-2 | IC50 | 49.55 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | EOL1 | IC50 | 12.9 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | ES1 | IC50 | 0.2215 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | ES3 | IC50 | 15.02 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | ES4 | IC50 | 0.7395 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | ES5 | IC50 | 4177.96 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | ES6 | IC50 | 11.24 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | ES7 | IC50 | 5.871 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | ES8 | IC50 | 1.649 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | ESS-1 | IC50 | 1.516 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | ETK-1 | IC50 | 0.9788 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | EVSA-T | IC50 | 30.73 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | EW-1 | IC50 | 1.903 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | EW-11 | IC50 | 50.72 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | EW-13 | IC50 | 0.9028 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | EW-16 | IC50 | 1.063 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | EW-18 | IC50 | 2.629 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | EW-24 | IC50 | 68.73 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | EW-3 | IC50 | 274.73 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | EW-7 | IC50 | 2.245 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | FaDu | IC50 | 26.21 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | FTC-133 | IC50 | 30.46 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | G-361 | IC50 | 0.7013 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | G-401 | IC50 | 1.509 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | G-402 | IC50 | 5.265 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | GAK | IC50 | 13.53 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | GAMG | IC50 | 1.785 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | GB-1 | IC50 | 1.189 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | GCIY | IC50 | 6.592 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | GCT | IC50 | 6.612 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | GDM-1 | IC50 | 4.305 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | Geminin | Potency | 3349.8 | nM | None |
| Homo sapiens | GI-1 | IC50 | 2.431 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | GI-ME-N | IC50 | 6.085 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | GMS-10 | IC50 | 106.19 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | GOTO | IC50 | 73.03 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | GP5d | IC50 | 3.087 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | GR-ST | IC50 | 3.907 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | GT3TKB | IC50 | 0.6555 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | H4 | IC50 | 0.975 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | HAL-01 | IC50 | 5.017 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | HC-1 | IC50 | 3.981 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | HCC1143 | IC50 | 106.5 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | HCC1187 | IC50 | 22.63 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | HCC1395 | IC50 | 182.18 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | HCC1419 | IC50 | 61.19 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | HCC1569 | IC50 | 12.8 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | HCC1599 | IC50 | 11.89 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | HCC1806 | IC50 | 1.38 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | HCC1937 | IC50 | 40.11 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | HCC1937 | IC50 | 10000.0 | nM | 10.1016/j.bmcl.2015.03.081 |
| Homo sapiens | HCC1937 | Inhibition | 0.0 | % | 10.1016/j.bmcl.2015.03.081 |
| Homo sapiens | HCC1954 | IC50 | 9.187 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | HCC2157 | IC50 | 1.284 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | HCC2218 | IC50 | 30.8 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | HCC 2998 | GI50 | 0.1 | nM | None |
| Homo sapiens | HCC 2998 | IC50 | 1.051 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | HCC38 | IC50 | 3.833 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | HCC70 | IC50 | 4.791 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | HCE-4 | IC50 | 1.305 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | HCE-T | IC50 | 4.068 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | HCT-116 | GI50 | 0.1 | nM | None |
| Homo sapiens | HCT-116 | IC50 | 0.8 | nM | 10.1016/j.ejmech.2018.08.055 |
| Homo sapiens | HCT-116 | IC50 | 4.687 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | HCT-15 | GI50 | 0.1 | nM | None |
| Homo sapiens | HCT-15 | IC50 | 0.7166 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | HDLM-2 | IC50 | 19.46 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | HD-MY-Z | IC50 | 23.27 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | HEC-1 | IC50 | 9.093 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | HEL | IC50 | 4.136 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | HeLa | IC50 | 3.0 | nM | 10.1016/j.ejmech.2018.08.055 |
| Homo sapiens | HepG2 | IC50 | 44.7 | nM | 10.1021/jm200848t |
| Homo sapiens | HGC-27 | IC50 | 0.3383 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | HH | IC50 | 9.802 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | Histone deacetylase 6 | Inhibition | -5.6 | % | 10.6019/CHEMBL4808148 |
| Homo sapiens | Histone deacetylase 6 | Inhibition | 24.16 | % | 10.6019/CHEMBL4808148 |
| Homo sapiens | HL-60 | GI50 | 0.1 | nM | None |
| Homo sapiens | HL-60 | IC50 | 5.002 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | HLE | IC50 | 0.08261 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | HMV-2 cell line | IC50 | 0.3944 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | HN | IC50 | 303.5 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | HO-1-N-1 | IC50 | 1.656 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | HOP-62 | GI50 | 0.1 | nM | None |
| Homo sapiens | HOP-62 | IC50 | 1.044 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | HOP-92 | GI50 | 0.1 | nM | None |
| Homo sapiens | HOP-92 | IC50 | 91.49 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | HOS | IC50 | 0.2152 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | HPAF-II | IC50 | 20.98 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | Hs-578T | GI50 | 0.1 | nM | None |
| Homo sapiens | Hs-578T | IC50 | 3.0 | nM | 10.1016/j.ejmech.2018.08.055 |
| Homo sapiens | Hs-578T | IC50 | 115.35 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | HSC-2 | IC50 | 0.3625 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | HSC-3 | IC50 | 0.7862 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | HSC-4 | IC50 | 29.92 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | HT | IC50 | 20.47 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | HT-1080 | IC50 | 0.8424 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | HT1197 | IC50 | 34.55 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | HT-1376 | IC50 | 21.23 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | HT-144 | IC50 | 1.72 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | HT-29 | GI50 | 0.1 | nM | None |
| Homo sapiens | HT-29 | IC50 | 0.4993 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | HT-3 | IC50 | 14.97 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | HT55 | IC50 | 42.54 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | HTC-C3 | IC50 | 2.941 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | HuCCT-1 | IC50 | 2.609 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | Huh-7 | CC50 | 6250.0 | nM | 10.1073/pnas.0802982105 |
| Homo sapiens | Huh-7 | IC50 | 4.5 | nM | 10.1021/jm200848t |
| Homo sapiens | Huh-7 | IC50 | 7.111 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | HuO-3N1 | IC50 | 424.73 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | HuP-T3 | IC50 | 3.811 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | HuP-T4 | IC50 | 2.536 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | HuTu80 | IC50 | 0.3281 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | HUVEC | IC50 | 0.55 | nM | 10.1021/acs.jnatprod.6b00194 |
| Homo sapiens | IA-LM | IC50 | 0.3929 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | IGR-1 | IC50 | 0.8634 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | IGROV-1 | GI50 | 0.1 | nM | None |
| Homo sapiens | IGROV-1 | IC50 | 0.156 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | IM-9 | IC50 | 96.46 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | IMR-5 | IC50 | 9.506 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | IPC-298 | IC50 | 22.09 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | IST-MEL1 | IC50 | 4.064 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | IST-MES1 | IC50 | 54.65 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | IST-SL1 | IC50 | 6.374 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | IST-SL2 | IC50 | 7.032 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | J82 | IC50 | 1.41 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | JAR | IC50 | 1219.48 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | JEG-3 | IC50 | 5.014 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | JIYOYE | IC50 | 7.805 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | J-RT3-T3-5 | IC50 | 13.48 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | JVM-2 | IC50 | 3045.95 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | JVM-3 | IC50 | 5300.22 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | K052 | IC50 | 5.843 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | K5 | IC50 | 5.585 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | K562 | GI50 | 0.1 | nM | None |
| Homo sapiens | K562 | IC50 | 6.886 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | KALS-1 | IC50 | 3.194 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | KARPAS-299 | IC50 | 170.31 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | KARPAS-422 | IC50 | 10.63 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | KARPAS-45 | IC50 | 5.818 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | KB | IC50 | 0.18 | nM | 10.1016/s0960-894x(00)00555-2 |
| Homo sapiens | KB 3-1 | IC50 | 0.053 | nM | 10.1021/acs.jnatprod.8b00708 |
| Homo sapiens | KB 3-1 | IC50 | 0.061 | nM | 10.1021/acs.jnatprod.7b00064 |
| Homo sapiens | KB 3-1 | IC50 | 0.065 | nM | 10.1021/acs.jnatprod.8b01086 |
| Homo sapiens | KB 3-1 | IC50 | 0.089 | nM | 10.1021/acs.jnatprod.9b00604 |
| Homo sapiens | KB 3-1 | IC50 | 0.19 | nM | 10.1016/s0960-894x(00)00555-2 |
| Homo sapiens | KB 3-1 | IC50 | 0.22 | nM | 10.1021/acs.jnatprod.6b00194 |
| Homo sapiens | KB 3-1 | IC50 | 3.0 | nM | 10.1016/j.ejmech.2018.08.055 |
| Homo sapiens | KB 3-1 | IC50 | 8.9 | 10^-5 uM | 10.1021/acs.jnatprod.0c00486 |
| Homo sapiens | KB 3-1 | IC50 | 220.0 | nM | 10.1021/acs.jnatprod.7b00764 |
| Homo sapiens | KB 3-1 | IC50 | 69000.0 | nM | 10.1021/acs.jnatprod.1c00975 |
| Homo sapiens | KB-V1 | IC50 | 3.0 | nM | 10.1016/j.ejmech.2018.08.055 |
| Homo sapiens | KE-37 | IC50 | 1.914 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | KG-1 | IC50 | 5.098 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | KGN | IC50 | 0.6173 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | KINGS-1 | IC50 | 34.69 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | KLE | IC50 | 40.4 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | KM12 | GI50 | 0.1 | nM | None |
| Homo sapiens | KM12 | IC50 | 2.236 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | KM-H2 | IC50 | 9.061 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | KMOE-2 | IC50 | 64.56 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | KMS-12-PE | IC50 | 50.95 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | KNS-42 | IC50 | 3.915 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | KNS-81-FD | IC50 | 84.25 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | KOSC-2 | IC50 | 2.833 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | KP-4 | IC50 | 0.6818 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | KP-N-YN | IC50 | 69.64 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | KP-N-YS | IC50 | 3.934 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | KS-1 | IC50 | 1.759 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | KU-19-19 | IC50 | 1598.52 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | KU812 cell line | IC50 | 3.454 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | KURAMOCHI | IC50 | 6.054 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | KY821 | IC50 | 796.17 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | KYSE-140 | IC50 | 1.226 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | KYSE-150 cell line | IC50 | 0.4989 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | KYSE-180 | IC50 | 0.6007 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | KYSE-270 | IC50 | 0.4449 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | KYSE-410 | IC50 | 1.023 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | KYSE-450 | IC50 | 0.2674 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | KYSE-510 | IC50 | 0.07379 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | KYSE-520 cell line | IC50 | 10.44 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | KYSE-70 cell line | IC50 | 7.581 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | L-363 | IC50 | 5.879 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | L-428 | IC50 | 46.25 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | L-540 | IC50 | 10.73 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | LAMA-84 | IC50 | 18.88 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | LAN-6 | IC50 | 346.08 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | LB1047-RCC | IC50 | 1.998 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | LB2241-RCC | IC50 | 5.548 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | LB2518-MEL | IC50 | 17.61 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | LB373-MEL-D | IC50 | 18.13 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | LB647-SCLC | IC50 | 3.096 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | LB771-HNC | IC50 | 8.458 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | LB831-BLC | IC50 | 6.034 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | LB996-RCC | IC50 | 6.031 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | LC-1F | IC50 | 34.9 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | LC-2-ad | IC50 | 0.003774 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | LC4-1 | IC50 | 12.75 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | LCLC-103H cell line | IC50 | 0.3096 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | LCLC-97TM1 | IC50 | 0.4441 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | LK-2 | IC50 | 4.855 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | LN-405 | IC50 | 136.23 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | LNCaP-Clone-FGC | IC50 | 4.258 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | LOUCY | IC50 | 4.346 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | LoVo | IC50 | 1.847 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | LOX IMVI | GI50 | 0.1 | nM | None |
| Homo sapiens | LOX IMVI | IC50 | 383.55 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | LP-1 | IC50 | 200.47 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | LS-1034 | IC50 | 0.912 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | LS-123 | IC50 | 0.9602 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | LS-411N | IC50 | 23.62 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | LS-513 | IC50 | 32.95 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | LU-134-A | IC50 | 15.75 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | LU-139 | IC50 | 47.54 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | LU-165 | IC50 | 117.25 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | Lu-65 | IC50 | 21.01 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | LU-99A | IC50 | 5.329 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | LXF-289 cell line | IC50 | 0.2269 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | M059J | IC50 | 1.337 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | M14 | GI50 | 0.1 | nM | None |
| Homo sapiens | M14 | IC50 | 37.33 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | Malme-3M | GI50 | 10.0 | nM | None |
| Homo sapiens | MC116 | IC50 | 3.865 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | MC-CAR | IC50 | 9.733 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | MCF7 | Activity | 3.0 | % | 10.1016/j.bmc.2018.10.005 |
| Homo sapiens | MCF7 | Activity | nan | None | 10.1016/j.bmc.2018.10.005 |
| Homo sapiens | MCF7 | ED50 | 0.0015 | uM | 10.1016/j.bmcl.2009.04.077 |
| Homo sapiens | MCF7 | GI50 | 0.1 | nM | None |
| Homo sapiens | MCF7 | IC50 | 0.074 | nM | 10.1021/acs.jnatprod.8b00708 |
| Homo sapiens | MCF7 | IC50 | 0.08657 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | MCF7 | IC50 | 0.15 | nM | 10.1021/acs.jnatprod.7b00064 |
| Homo sapiens | MCF7 | IC50 | 0.24 | nM | 10.1021/acs.jnatprod.9b00604 |
| Homo sapiens | MCF7 | IC50 | 38.17 | nM | 10.1016/j.bmc.2018.10.005 |
| Homo sapiens | MCF7 | IC50 | 81000.0 | nM | 10.1021/acs.jnatprod.1c00975 |
| Homo sapiens | MC-IXC | IC50 | 3.056 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | MDA-MB-134-VI | IC50 | 116.4 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | MDA-MB-157 | IC50 | 945.71 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | MDA-MB-175-VII | IC50 | 421.11 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | MDA-MB-231 | GI50 | 0.1 | nM | None |
| Homo sapiens | MDA-MB-231 | IC50 | 24.61 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | MDA-MB-361 | IC50 | 16.53 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | MDA-MB-415 | IC50 | 20.0 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | MDA-MB-435 | GI50 | 0.1 | nM | None |
| Homo sapiens | MDA-MB-453 | IC50 | 83.15 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | MDA-MB-468 | IC50 | 1.753 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | MDA-N | GI50 | 0.1 | nM | None |
| Homo sapiens | ME-180 | IC50 | 5.737 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | MEG-01 | IC50 | 1.525 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | MEL-HO | IC50 | 1.688 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | MEL-JUSO | IC50 | 0.9276 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | MES-SA | IC50 | 1.975 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | MeWo | IC50 | 759.64 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | MFE-280 | IC50 | 82.01 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | MFE-296 | IC50 | 2.684 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | MFH-ino | IC50 | 0.8849 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | MFM-223 | IC50 | 1769.39 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | MG-63 | IC50 | 0.1647 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | MHH-CALL-2 | IC50 | 943.52 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | MHH-ES-1 | IC50 | 0.893 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | MHH-NB-11 | IC50 | 15.15 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | MHH-PREB-1 | IC50 | 7.508 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | MIA PaCa-2 | IC50 | 1.314 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | MKN-1 | IC50 | 2.648 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | MKN-28 | IC50 | 0.4616 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | MKN-45 | IC50 | 4.379 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | MKN-7 | IC50 | 82.83 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | ML-2 | IC50 | 2.463 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | MLMA | IC50 | 14.06 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | MM1.S | IC50 | 1.0 | nM | 10.1016/j.ejmech.2018.08.055 |
| Homo sapiens | MMAC-SF | IC50 | 23.04 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | MN-60 | IC50 | 290.38 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | Mo | IC50 | 653.83 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | MOLT-16 | IC50 | 3.413 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | MOLT-4 | GI50 | 0.1 | nM | None |
| Homo sapiens | MOLT-4 | IC50 | 2.516 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | MONO-MAC-6 | IC50 | 17.36 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | MPP-89 | IC50 | 8.289 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | MRK-nu-1 | IC50 | 0.9001 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | MS-1 | IC50 | 10.25 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | MSTO-211H | IC50 | 4670.91 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | MV4-11 | IC50 | 1.696 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | MZ1-PC | IC50 | 0.6069 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | MZ2-MEL | IC50 | 2.149 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | MZ7-mel | IC50 | 17.1 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NALM-6 | IC50 | 2.178 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NB1 | IC50 | 14.59 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NB10 | IC50 | 11.04 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NB12 | IC50 | 56.02 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NB13 | IC50 | 0.447 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NB5 | IC50 | 10.65 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NB6 | IC50 | 17.54 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NB69 | IC50 | 8.07 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCCIT | IC50 | 1.729 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI/ADR-RES | GI50 | 0.1 | nM | None |
| Homo sapiens | NCI-H1092 | IC50 | 111.33 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H1155 | IC50 | 57.89 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H1299 | IC50 | 0.88 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H1304 | IC50 | 17.51 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H1355 | IC50 | 0.9152 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H1395 | IC50 | 54.89 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H1417 | IC50 | 21.0 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H1436 | IC50 | 7.833 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H1437 | IC50 | 0.6893 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H1522 | IC50 | 153.99 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H1563 | IC50 | 41.84 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H1573 | IC50 | 6.416 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H1581 | IC50 | 45.09 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H1618 | IC50 | 7.621 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H1623 | IC50 | 16.87 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H1648 | IC50 | 0.9819 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H1650 | IC50 | 9.541 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H1651 | IC50 | 3.712 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H1693 | IC50 | 634.13 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H1694 | IC50 | 69.12 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H1703 | IC50 | 7.758 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H1734 | IC50 | 15.97 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H1755 | IC50 | 87.37 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H1770 | IC50 | 0.9066 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H1792 | IC50 | 8.278 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H1793 | IC50 | 21.02 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H1838 | IC50 | 1210.4 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H187 | IC50 | 4370.6 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H1882 | IC50 | 319.36 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H1963 | IC50 | 11.97 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H1993 | IC50 | 84.73 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H2009 | IC50 | 0.8623 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H2030 | IC50 | 0.6991 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H2052 | IC50 | 429.39 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H2081 | IC50 | 45.96 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H2087 | IC50 | 3.107 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H209 | IC50 | 20.86 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H2122 | IC50 | 0.4101 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H2126 | IC50 | 15.62 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H2141 | IC50 | 13.74 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H2170 | IC50 | 5.217 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H2171 | IC50 | 9.623 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H2196 | IC50 | 84.45 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H2227 | IC50 | 2937.33 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H2228 | IC50 | 0.4727 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H226 | GI50 | 0.1 | nM | None |
| Homo sapiens | NCI-H226 | IC50 | 42.05 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H23 | GI50 | 0.1 | nM | None |
| Homo sapiens | NCI-H23 | IC50 | 23.76 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H2342 | IC50 | 0.5766 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H2347 | IC50 | 38.51 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H2405 | IC50 | 12.65 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H2452 | IC50 | 278.65 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H28 | IC50 | 22.03 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H292 | IC50 | 1.419 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H322M | GI50 | 0.1 | nM | None |
| Homo sapiens | NCI-H322M | IC50 | 4464.24 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H345 | IC50 | 2111.57 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H358 | IC50 | 2.484 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H441 | IC50 | 2.526 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H446 | IC50 | 21.38 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H460 | GI50 | 0.1 | nM | None |
| Homo sapiens | NCI-H460 | IC50 | 0.3333 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H510A | IC50 | 11.85 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H520 | IC50 | 2.949 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H522 | GI50 | 0.1 | nM | None |
| Homo sapiens | NCI-H522 | IC50 | 0.6353 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H524 | IC50 | 23.13 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H526 | IC50 | 7.236 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H596 | IC50 | 11.63 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H64 | IC50 | 8.249 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H650 | IC50 | 0.1703 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H661 | IC50 | 30.09 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H69 | IC50 | 14.84 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H716 | IC50 | 3347.21 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H719 | IC50 | 206.03 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H720 | IC50 | 2316.81 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H727 | IC50 | 1.796 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H747 | IC50 | 2.539 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H748 | IC50 | 43.03 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H810 | IC50 | 0.3221 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H82 | IC50 | 36.63 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H838 | IC50 | 11.78 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H889 | IC50 | 36.02 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-N87 | IC50 | 30.3 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NEC8 | IC50 | 3.53 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NH-12 | IC50 | 0.8914 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NKM-1 | IC50 | 2.103 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NMC-G1 | IC50 | 1.755 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | no-10 | IC50 | 5.564 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | no-11 | IC50 | 51.73 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NOMO-1 | IC50 | 8.553 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NOS-1 | IC50 | 2.716 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NTERA-2-cl-D1 | IC50 | 0.7182 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NUGC-3 | IC50 | 1.161 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NY | IC50 | 1.564 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | OAW-28 | IC50 | 7.955 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | OAW-42 | IC50 | 2.179 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | OCI-AML2 | IC50 | 3.066 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | OCUB-M | IC50 | 1.025 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | OE19 | IC50 | 4.661 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | OE33 | IC50 | 7.633 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | OMC-1 | IC50 | 36.33 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | ONS-76 | IC50 | 4.099 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | OPM-2 | IC50 | 64.46 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | OS-RC-2 | IC50 | 1.206 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | OVCAR-3 | GI50 | 0.1 | nM | None |
| Homo sapiens | OVCAR-3 | IC50 | 4.132 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | OVCAR-4 | GI50 | 0.4581 | nM | None |
| Homo sapiens | OVCAR-4 | IC50 | 1.612 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | OVCAR-5 | GI50 | 0.1 | nM | None |
| Homo sapiens | OVCAR-5 | IC50 | 2.84 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | OVCAR-8 | GI50 | 0.1 | nM | None |
| Homo sapiens | OVCAR-8 | IC50 | 1.063 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | P12-Ichikawa | IC50 | 11.02 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | P30-OHK | IC50 | 4.49 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | P31-FUJ | IC50 | 6177.42 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | PA-1 | IC50 | 0.1737 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | PANC-03-27 | IC50 | 0.132 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | PANC-08-13 | IC50 | 31.13 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | Panc1005 | IC50 | 1.12 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | PC-14 | IC50 | 4.214 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | PC-3 | GI50 | 0.1 | nM | None |
| Homo sapiens | PC-3 | GI50 | 1.7 | nM | 10.1021/acsmedchemlett.7b00131 |
| Homo sapiens | PC-3 | IC50 | 0.25 | nM | 10.1021/acs.jnatprod.7b00064 |
| Homo sapiens | PC-3 | IC50 | 1.6 | nM | 10.1021/acs.jnatprod.9b00604 |
| Homo sapiens | PC-3 | IC50 | 2.2 | nM | 10.1021/acs.jnatprod.8b00708 |
| Homo sapiens | PC-3 | IC50 | 23.37 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | PC-3 | IC50 | 71000.0 | nM | 10.1021/acs.jnatprod.1c00975 |
| Homo sapiens | PF-382 | IC50 | 8.684 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | PFSK-1 | IC50 | 13.32 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | PLC-PRF-5 | IC50 | 62.91 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | Pregnane X receptor | Activity | nan | None | 10.1124/dmd.110.035105 |
| Homo sapiens | Pregnane X receptor | EC50 | 12600.0 | nM | 10.1124/dmd.110.035105 |
| Homo sapiens | Pregnane X receptor | EC50 | 31600.0 | nM | 10.1124/dmd.110.035105 |
| Homo sapiens | Pregnane X receptor | Efficacy | 62.5 | % | 10.1124/dmd.110.035105 |
| Homo sapiens | Pregnane X receptor | Efficacy | 89.9 | % | 10.1124/dmd.110.035105 |
| Homo sapiens | PSN1 | IC50 | 0.1731 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | QIMR-WIL | IC50 | 1.186 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | Raji | IC50 | 104.92 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | Ramos-2G6-4C10 | IC50 | 9.621 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | RCC10RGB | IC50 | 19.69 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | RCM-1 | IC50 | 15.22 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | RD | IC50 | 4.422 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | REH | IC50 | 1.76 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | RERF-LC-MS | IC50 | 24.5 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | RH-1 | IC50 | 0.9968 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | RKO | IC50 | 0.06474 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | RL | IC50 | 1660.4 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | RMG-I | IC50 | 35.3 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | RO82-W-1 | IC50 | 433.97 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | RPMI-2650 | IC50 | 2.083 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | RPMI-6666 | IC50 | 1.498 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | RPMI-7951 | IC50 | 1.049 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | RPMI-8226 | GI50 | 0.1 | nM | None |
| Homo sapiens | RPMI-8226 | IC50 | 1.0 | nM | 10.1016/j.ejmech.2018.08.055 |
| Homo sapiens | RPMI-8226 | IC50 | 6.712 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | RPMI 8402 | IC50 | 4.451 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | RPMI-8866 | IC50 | 19.84 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | RS4-11 | IC50 | 2.017 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | RT-112 | IC50 | 0.6143 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | RT-4 | IC50 | 202.57 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | RVH-421 | IC50 | 14.32 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | RXF 393 | GI50 | 0.1 | nM | None |
| Homo sapiens | RXF 393 | IC50 | 3.41 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | S-117 | IC50 | 2508.45 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SAOS-2 | IC50 | 1462.76 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SAS | IC50 | 344.06 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SBC-1 | IC50 | 920.42 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SBC-5 | IC50 | 0.9115 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SCC-15 | IC50 | 5.981 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SCC-25 | IC50 | 1.222 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SCC-3 | IC50 | 110.46 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SCC-4 | IC50 | 0.8766 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SCC-9 | IC50 | 122.4 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SCH | IC50 | 2022.54 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SCLC-21H | IC50 | 7.591 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SF-126 | IC50 | 3.466 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SF-268 | GI50 | 0.1 | nM | None |
| Homo sapiens | SF-268 | IC50 | 4.655 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SF-295 | GI50 | 0.1 | nM | None |
| Homo sapiens | SF-295 | IC50 | 1.918 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SF-539 | GI50 | 0.1 | nM | None |
| Homo sapiens | SF-539 | IC50 | 2.271 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SH-4 | IC50 | 7.728 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SHP77 | IC50 | 4.924 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SIG-M5 | IC50 | 0.1687 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SiHa | IC50 | 57.13 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SIMA | IC50 | 19.08 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SJRH30 | IC50 | 12.95 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SJSA-1 | IC50 | 2.086 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SK-CO-1 | IC50 | 9.13 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SKG-IIIa | IC50 | 32.31 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SK-HEP1 | IC50 | 1.112 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SK-LMS-1 | IC50 | 0.646 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SK-LU-1 | IC50 | 0.8665 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SK-MEL-1 | IC50 | 3670.91 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SK-MEL-2 | GI50 | 0.1 | nM | None |
| Homo sapiens | SK-MEL-2 | IC50 | 7.191 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SK-MEL-24 | IC50 | 952.59 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SK-MEL-28 | GI50 | 0.1 | nM | None |
| Homo sapiens | SK-MEL-28 | IC50 | 659.83 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SK-MEL3 | IC50 | 20.88 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SK-MEL-30 | IC50 | 1.343 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SK-MEL-5 | GI50 | 0.1 | nM | None |
| Homo sapiens | SK-MES-1 | IC50 | 1.244 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SK-MM-2 | IC50 | 17.25 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SK-N-AS | IC50 | 1055.68 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SK-N-DZ | IC50 | 7.593 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SK-NEP-1 | IC50 | 10.04 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SK-N-FI | IC50 | 953.88 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SK-OV-3 | GI50 | 0.1 | nM | None |
| Homo sapiens | SK-OV-3 | IC50 | 0.0236 | nM | 10.1021/acs.jnatprod.7b00064 |
| Homo sapiens | SK-OV-3 | IC50 | 0.24 | nM | 10.1021/acs.jnatprod.8b00708 |
| Homo sapiens | SK-OV-3 | IC50 | 0.28 | nM | 10.1021/acs.jnatprod.9b00604 |
| Homo sapiens | SK-OV-3 | IC50 | 1.495 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SK-OV-3 | IC50 | 290000.0 | nM | 10.1021/acs.jnatprod.1c00975 |
| Homo sapiens | SK-PN-DW | IC50 | 1.065 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SK-UT-1 | IC50 | 0.8923 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SMMC-7721 | IC50 | 2.3 | nM | 10.1021/jm200848t |
| Homo sapiens | SN12C | GI50 | 0.1 | nM | None |
| Homo sapiens | SN12C | IC50 | 9.392 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SNB-19 | GI50 | 0.1 | nM | None |
| Homo sapiens | SNB-75 | GI50 | 0.1 | nM | None |
| Homo sapiens | SNB-75 | IC50 | 3.009 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SNG-M | IC50 | 0.5713 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SNU1 | IC50 | 62.74 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SNU-16 | IC50 | 31.0 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SNU-387 | IC50 | 5.656 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SNU-387 | IC50 | 20.0 | nM | 10.1021/jm200848t |
| Homo sapiens | SNU-398 | Activity | 11.8 | % | 10.1021/jm200848t |
| Homo sapiens | SNU-398 | Activity | 13.7 | % | 10.1021/jm200848t |
| Homo sapiens | SNU-398 | Activity | 70.1 | % | 10.1021/jm200848t |
| Homo sapiens | SNU-398 | IC50 | 2.9 | nM | 10.1021/jm200848t |
| Homo sapiens | SNU-398 | IC50 | 5.0 | nM | 10.1021/jm200848t |
| Homo sapiens | SNU-423 | IC50 | 1.666 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SNU-423 | IC50 | 10.3 | nM | 10.1021/jm200848t |
| Homo sapiens | SNU-449 | IC50 | 1.905 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SNU-449 | IC50 | 19.9 | nM | 10.1021/jm200848t |
| Homo sapiens | SNU-475 | IC50 | 11.6 | nM | 10.1021/jm200848t |
| Homo sapiens | SNU-475 | IC50 | 42.74 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SNU-5 | IC50 | 30.44 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SNU-C1 | IC50 | 63.22 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SNU-C2B | IC50 | 4.297 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SR | GI50 | 0.1 | nM | None |
| Homo sapiens | SR | IC50 | 3.652 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | ST486 | IC50 | 0.7212 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SU-DHL-1 | IC50 | 516.49 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SUP-T1 | IC50 | 33.9 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SW1088 | IC50 | 5.791 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SW13 | IC50 | 5.012 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SW1417 | IC50 | 324.99 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SW1463 | IC50 | 51.7 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SW1573 | IC50 | 14.61 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SW1710 | IC50 | 0.02135 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SW1783 | IC50 | 1.484 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SW1990 | IC50 | 33.2 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SW48 | IC50 | 4.197 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SW-620 | GI50 | 0.1 | nM | None |
| Homo sapiens | SW-620 | IC50 | 0.6481 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SW626 | IC50 | 1.985 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SW684 | IC50 | 3094.52 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SW756 | IC50 | 38.94 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SW780 | IC50 | 4237.97 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SW837 | IC50 | 2.47 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SW872 | IC50 | 0.7737 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SW948 | IC50 | 17.77 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SW 954 | IC50 | 0.4357 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SW 962 | IC50 | 1.036 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SW982 | IC50 | 0.9994 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | T-24 | IC50 | 20.65 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | T47D | GI50 | 0.1 | nM | None |
| Homo sapiens | T47D | IC50 | 278.17 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | T84 | IC50 | 0.2398 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | T98G | IC50 | 19.96 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | TALL-1 | IC50 | 1863.1 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | TCC-SUP | IC50 | 4.497 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | TE-1 | IC50 | 2.021 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | TE-10 | IC50 | 0.7192 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | TE-11 | IC50 | 1.204 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | TE-12 | IC50 | 5.474 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | TE-15 | IC50 | 0.2254 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | TE-441-T | IC50 | 26.34 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | TE-5 | IC50 | 3.044 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | TE-6 | IC50 | 22.99 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | TE-8 | IC50 | 0.1111 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | TE-9 | IC50 | 1.568 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | TGBC1TKB | IC50 | 39.54 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | TGBC24TKB | IC50 | 2.752 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | TGW | IC50 | 13.48 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | THP-1 | IC50 | 23.54 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | TK-10 | GI50 | 0.1 | nM | None |
| Homo sapiens | TK-10 | IC50 | 2.047 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | TT | IC50 | 2580.7 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | Tubulin | IC50 | 3.5 | nM | 10.1016/j.ejmech.2018.08.055 |
| Homo sapiens | Tubulin beta-2 chain | TP | 98.0 | % | 10.1021/jm050524f |
| Homo sapiens | TUR | IC50 | 1.856 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | TYK-nu | IC50 | 61.36 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | U-118-MG | IC50 | 17.98 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | U-251 | GI50 | 0.1 | nM | None |
| Homo sapiens | U-251 | IC50 | 10.8 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | U-266 | IC50 | 1.0 | nM | 10.1016/j.ejmech.2018.08.055 |
| Homo sapiens | U-266 | IC50 | 9.719 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | U2OS | IC50 | 0.104 | nM | 10.1021/acs.jnatprod.7b00064 |
| Homo sapiens | U2OS | IC50 | 2004.75 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | U-698-M | IC50 | 7.758 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | U-87 MG | IC50 | 21.8 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | UACC-257 | GI50 | 0.1 | nM | None |
| Homo sapiens | UACC-257 | IC50 | 29.72 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | UACC-62 | GI50 | 0.1 | nM | None |
| Homo sapiens | UACC-62 | IC50 | 128.57 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | UACC-812 | IC50 | 1003.75 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | UACC-893 | IC50 | 45.5 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | UMC-11 | IC50 | 64.42 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | UMUC3 | IC50 | 1.853 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | UO-31 | GI50 | 0.1 | nM | None |
| Homo sapiens | UO-31 | IC50 | 3.116 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | VA-ES-BJ | IC50 | 4.345 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | VM-CUB-1 | IC50 | 3.087 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | VMRC-RCZ | IC50 | 0.1355 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | WM-115 | IC50 | 1139.14 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | WSU-NHL | IC50 | 4.146 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | YAPC | IC50 | 348.75 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | YKG-1 | IC50 | 1.238 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | YT | IC50 | 18.74 | nM | 10.6019/CHEMBL1201861 |
| Mus musculus | L929 | IC50 | 0.001 | ug.mL-1 | 10.1021/np000629f |
| Mus musculus | L929 | IC50 | 0.75 | nM | 10.1021/acs.jnatprod.8b00708 |
| Mus musculus | L929 | IC50 | 1.4 | nM | 10.1021/acs.jnatprod.9b00604 |
| Mus musculus | L929 | IC50 | 1.7 | nM | 10.1021/acs.jnatprod.7b00064 |
| Mus musculus | L929 | IC50 | 2.6 | nM | 10.1021/acs.jnatprod.0c00486 |
| Mus musculus | L929 | IC50 | 2.75 | nM | 10.1021/acs.jnatprod.8b01086 |
| Mus musculus | L929 | IC50 | 1400.0 | nM | 10.1021/acs.jnatprod.7b00764 |
| Mus musculus | L929 | IC50 | 1400000.0 | nM | 10.1021/acs.jnatprod.1c00975 |
| Mus musculus | Nuclear receptor ROR-gamma | Potency | 35481.3 | nM | None |
| Plasmodium falciparum | Plasmodium falciparum | EC50 | 4.09 | nM | 10.1073/pnas.0802982105 |
| Plasmodium falciparum | Plasmodium falciparum | EC50 | 1250.0 | nM | 10.1073/pnas.0802982105 |
| Plasmodium falciparum | Plasmodium falciparum | Potency | 1.3 | nM | None |
| Rattus norvegicus | Nuclear receptor subfamily 1 group I member 2 | EC50 | 10.0 | nM | 10.1124/dmd.110.035105 |
| Rattus norvegicus | Nuclear receptor subfamily 1 group I member 2 | Efficacy | 102.9 | % | 10.1124/dmd.110.035105 |
| Rattus norvegicus | Peripheral myelin protein 22 | Potency | 11.2 | nM | None |
| Rattus norvegicus | Peripheral myelin protein 22 | Potency | 57.3 | nM | None |
| Severe acute respiratory syndrome coronavirus 2 | Replicase polyprotein 1ab | Inhibition | 28.16 | % | 10.6019/CHEMBL4495564 |
| Severe acute respiratory syndrome coronavirus 2 | SARS-CoV-2 | Inhibition | -0.01 | % | 10.6019/CHEMBL4495565 |
| Sus scrofa | Sus scrofa | EC50 | 670.0 | nM | 10.1016/s0960-894x(00)00555-2 |
| Sus scrofa | Sus scrofa | Tubulin polymerization | 90.0 | % | 10.1016/s0960-894x(00)00555-2 |
| None | BC1 cell line | IC50 | 1.993 | nM | 10.6019/CHEMBL1201861 |
| None | Molecular identity unknown | Activity | 5.1 | % | 10.1021/jm200848t |
| None | Molecular identity unknown | Activity | 5.4 | % | 10.1021/jm200848t |
| None | Molecular identity unknown | Activity | 56.3 | % | 10.1021/jm200848t |
| None | NON-PROTEIN TARGET | ED50 | 0.0012 | uM | 10.1016/j.bmcl.2009.04.077 |
| None | NON-PROTEIN TARGET | IC50 | 0.17 | nM | 10.1016/j.bmcl.2015.03.081 |
| None | NON-PROTEIN TARGET | IC50 | 1.8 | nM | 10.1021/jm200848t |
| None | NON-PROTEIN TARGET | IC50 | 3.8 | nM | 10.1021/jm200848t |
| None | NON-PROTEIN TARGET | IC50 | 6.7 | nM | 10.1021/jm200848t |
| None | NON-PROTEIN TARGET | IC50 | 12.7 | nM | 10.1021/jm200848t |
| None | NON-PROTEIN TARGET | IC50 | 14.8 | nM | 10.1021/jm200848t |
| None | NON-PROTEIN TARGET | IC50 | 22.3 | nM | 10.1021/jm200848t |
| None | NON-PROTEIN TARGET | IC50 | 61.3 | nM | 10.1021/jm200848t |
| None | NON-PROTEIN TARGET | IC50 | 100.0 | nM | 10.1021/jm200848t |
| None | NON-PROTEIN TARGET | IC50 | nan | ug.mL-1 | 10.1016/s0960-894x(98)00546-0 |
| None | Unchecked | Activity | 9.0 | % | 10.1038/nchembio853 |
| None | Unchecked | Activity | 31.0 | % | 10.1038/nchembio853 |
| None | Unchecked | Activity | 33.0 | % | 10.1038/nchembio853 |
| None | Unchecked | Activity | 76.0 | % | 10.1038/nchembio853 |
| None | Unchecked | Activity | 79.0 | % | 10.1038/nchembio853 |
| None | Unchecked | Activity | nan | None | 10.1021/acs.jnatprod.7b00704 |
| None | Unchecked | ED50 | 1.0 | uM | 10.1016/j.bmcl.2009.04.077 |
| None | Unchecked | IC50 | 1.0 | nM | 10.1016/j.ejmech.2018.08.055 |
| None | Unchecked | IC50 | 3.3 | nM | 10.1016/j.ejmech.2018.08.055 |
| None | Unchecked | IC50 | 3.5 | nM | 10.1016/j.ejmech.2018.08.055 |
| None | Unchecked | IFI | 4.688 | % | 10.1073/pnas.0802982105 |
| None | Unchecked | Ka | 7.5 | 10'8/M | 10.1016/j.bmcl.2008.12.018 |
| None | Unchecked | Kd | 1.3 | nM | 10.1038/nchembio853 |
| None | Unchecked | Potency | 25574.8 | nM | None |