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name Structure Reference Source Properties Activities Metabolism

7-(2-hydroxy-2-phenylacetamido)-3-{[(1-methyl-1H-1,2,3,4-tetrazol-5-yl)sulfanyl]methyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

AlkaPlorer ID: AK017282

Synonym: None

IUPAC Name: (6R,7R)-7-[[(2R)-2-hydroxy-2-phenylacetyl]amino]-3-[(1-methyltetrazol-5-yl)sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

Structure

SMILES: CN1N=NN=C1SCC1=C(C(=O)O)N2C(=O)[C@@H](NC(=O)[C@H](O)C3=CC=CC=C3)[C@H]2SC1

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InChI: InChI=1S/C18H18N6O5S2/c1-23-18(20-21-22-23)31-8-10-7-30-16-11(15(27)24(16)12(10)17(28)29)19-14(26)13(25)9-5-3-2-4-6-9/h2-6,11,13,16,25H,7-8H2,1H3,(H,19,26)(H,28,29)/t11-,13-,16-/m1/s1

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InChIKey: OLVCFLKTBJRLHI-AXAPSJFSSA-N

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Source

Species Genus Family Order Class Phylum Kingdom Domain
Apis cerana Apis Apidae Hymenoptera Insecta Arthropoda Metazoa Eukaryota

Properties Information

Molecule Weight: 462.5130000000001

TPSA？: 150.54

MolLogP？: -0.2255999999999989

Number of H-Donors: 3

Number of H-Acceptors: 10

RingCount: 4

Activities Information

Organism Target Name Standard Type Standard Value Standard Units doi
Campylobacter coli Campylobacter coli MIC 256.0 ug.mL-1 10.1128/aac.01655-08
Campylobacter coli Campylobacter coli MIC50 256.0 ug.mL-1 10.1128/aac.01655-08
Campylobacter coli Campylobacter coli MIC90 256.0 ug.mL-1 10.1128/aac.01655-08
Campylobacter jejuni Campylobacter jejuni MIC 8.0 ug.mL-1 10.1128/aac.01655-08
Campylobacter jejuni Campylobacter jejuni MIC50 256.0 ug.mL-1 10.1128/aac.01655-08
Campylobacter jejuni Campylobacter jejuni MIC90 256.0 ug.mL-1 10.1128/aac.01655-08
Cercopithecidae Monkey T1/2 0.5667 hr 10.1021/jm00074a002
Enterobacter Enterobacter MIC 50.0 ug.mL-1 10.1021/jm00214a018
Enterobacter cloacae Enterobacter cloacae MIC 3.1 ug.mL-1 10.1021/jm00193a001
Enterobacteriaceae Enterobacteriaceae MIC 0.39 ug.mL-1 10.1021/jm00214a018
Enterobacteriaceae Enterobacteriaceae MIC 50.0 ug.mL-1 10.1021/jm00214a018
Enterococcus Enterococcus MIC 50.0 ug.mL-1 10.1021/jm00214a018
Escherichia coli Escherichia coli Activity nan None 10.1128/aac.01677-09
Escherichia coli Escherichia coli MIC 0.063 ug.mL-1 10.1128/aac.01677-09
Escherichia coli Escherichia coli MIC 0.13 ug.mL-1 10.1128/aac.01677-09
Escherichia coli Escherichia coli MIC 0.25 ug.mL-1 10.1128/aac.01677-09
Escherichia coli Escherichia coli MIC 0.39 ug.mL-1 10.1021/jm00214a018
Escherichia coli Escherichia coli MIC 0.4 ug.mL-1 10.1021/jm00193a001
Escherichia coli Escherichia coli MIC 4.0 ug.mL-1 10.1016/j.ejmech.2012.03.008
Escherichia coli Escherichia coli Ratio 4.0 None 10.1016/j.ejmech.2012.03.008
Homo sapiens Adenosine A1 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Adenosine A2a receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Adenosine A3 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-1a adrenergic receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-2a adrenergic receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-2b adrenergic receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-2c adrenergic receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Beta-1 adrenergic receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Beta-2 adrenergic receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Bradykinin B2 receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Canalicular multispecific organic anion transporter 1 Activity 63.0 % 10.1021/jm7015683
Homo sapiens Canalicular multispecific organic anion transporter 1 Inhibition nan % 10.1124/dmd.111.041731
Homo sapiens Canalicular multispecific organic anion transporter 2 Inhibition nan % 10.1124/dmd.111.041731
Homo sapiens Cannabinoid CB1 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Cholecystokinin A receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Cholecystokinin B receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Cyclooxygenase-2 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Delta opioid receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine D1 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine D2 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine D3 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine transporter AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Endothelin receptor ET-A AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Equilibrative nucleoside transporter 1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Estrogen receptor alpha AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Gamma-aminobutyric acid receptor subunit alpha-1/alpha-2/beta-2/gamma-2 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Ghrelin receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Glucocorticoid receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens HERG AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Histamine H1 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Histamine H2 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Histamine H3 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Histone deacetylase 6 Inhibition -10.24 % 10.6019/CHEMBL4808148
Homo sapiens Histone deacetylase 6 Inhibition -5.03 % 10.6019/CHEMBL4808148
Homo sapiens Homo sapiens CL 0.012 mL.min-1.kg-1 10.1124/dmd.112.049312
Homo sapiens Homo sapiens CL 0.048 mL.min-1.kg-1 10.1124/dmd.112.049312
Homo sapiens Homo sapiens CL 3.6 mL.min-1.kg-1 10.1021/jm900403j
Homo sapiens Homo sapiens CL_renal 2.7 mL.min-1.kg-1 10.1021/jm900403j
Homo sapiens Homo sapiens T1/2 0.8 hr 10.1021/jm00074a002
Homo sapiens Kappa opioid receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Melanocortin receptor 3 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Monoamine oxidase A AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Motilin receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Multidrug resistance-associated protein 4 Inhibition nan % 10.1124/dmd.111.041731
Homo sapiens Mu opioid receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Muscarinic acetylcholine receptor M1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Muscarinic acetylcholine receptor M2 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Muscarinic acetylcholine receptor M3 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Neuronal acetylcholine receptor protein alpha-4 subunit AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Neuropeptide Y receptor type 1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Norepinephrine transporter AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Oligopeptide transporter small intestine isoform Ki 8100000.0 nM 10.1016/j.ejpb.2004.07.008
Homo sapiens Oligopeptide transporter small intestine isoform Ki 8100000.0 nM 10.1021/jm048982w
Homo sapiens Peroxisome proliferator-activated receptor gamma AC50 9700.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Peroxisome proliferator-activated receptor gamma AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Phosphodiesterase 3A AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Phosphodiesterase 4D AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Pregnane X receptor AC50 1500.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Pregnane X receptor AC50 1800.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Pregnane X receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Progesterone receptor AC50 3900.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Progesterone receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 1a (5-HT1a) receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2a (5-HT2a) receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2b (5-HT2b) receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2c (5-HT2c) receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 3a (5-HT3a) receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin transporter AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Solute carrier family 15 member 2 Ki 2800000.0 nM 10.1016/j.bmc.2011.06.027
Homo sapiens Solute carrier family 15 member 2 Ki 2818382.93 nM 10.1016/j.bmc.2011.06.027
Homo sapiens Solute carrier family 22 member 11 Ki 1140.0 nM 10.1016/s0014-2999(02)01306-7
Homo sapiens Solute carrier family 22 member 6 Ki 30.0 nM 10.1016/s0014-2999(02)01306-7
Homo sapiens Solute carrier family 22 member 7 IC50 1570000.0 nM 10.1016/s0014-2999(03)01381-5
Homo sapiens Solute carrier family 22 member 8 Ki 46.0 nM 10.1016/s0014-2999(02)01306-7
Homo sapiens Solute carrier organic anion transporter family member 1B1 Inhibition 30.2 % 10.1021/jm300212s
Homo sapiens Solute carrier organic anion transporter family member 1B3 Inhibition 16.5 % 10.1021/jm300212s
Homo sapiens Solute carrier organic anion transporter family member 2B1 Inhibition 2.7 % 10.1021/jm300212s
Homo sapiens Type-1 angiotensin II receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Vasopressin V1a receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Vasopressin V2 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Klebsiella Klebsiella MIC 1.56 ug.mL-1 10.1021/jm00214a018
Klebsiella pneumoniae Klebsiella pneumoniae MIC 0.4 ug.mL-1 10.1021/jm00193a001
Klebsiella pneumoniae Klebsiella pneumoniae MIC 100.0 ug.mL-1 10.1021/jm00193a001
Morganella morganii Morganella morganii MIC 6.25 ug.mL-1 10.1021/jm00214a018
Mus musculus Monoamine oxidase A Activity nan None 10.1021/jm800656v
Proteus mirabilis Proteus mirabilis MIC 0.8 ug.mL-1 10.1021/jm00193a001
Proteus mirabilis Proteus mirabilis MIC 6.25 ug.mL-1 10.1021/jm00214a018
Proteus vulgaris Proteus vulgaris MIC 0.8 ug.mL-1 10.1021/jm00193a001
Proteus vulgaris Proteus vulgaris MIC 1.56 ug.mL-1 10.1021/jm00214a018
Providencia Providencia MIC 3.12 ug.mL-1 10.1021/jm00214a018
Pseudomonas Pseudomonas MIC 100.0 ug.mL-1 10.1021/jm00214a018
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 100.0 ug.mL-1 10.1021/jm00193a001
Rattus norvegicus Androgen Receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Rattus norvegicus Cyclooxygenase-1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Rattus norvegicus GABA receptor alpha-1 subunit AC50 30000.0 nM 10.1038/s41467-023-40064-9
Rattus norvegicus Glutamate (NMDA) receptor subunit zeta 1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Rattus norvegicus Oligopeptide transporter, kidney isoform Ki 2800000.0 nM 10.1016/j.ejpb.2004.07.008
Rattus norvegicus Rattus norvegicus CL 5.0 mL.min-1.kg-1 10.1124/dmd.112.049312
Rattus norvegicus Rattus norvegicus CL 29.41 mL.min-1.kg-1 10.1124/dmd.112.049312
Rattus norvegicus Rattus norvegicus T1/2 0.25 hr 10.1021/jm00074a002
Rattus norvegicus Solute carrier family 22 member 6 Activity nan None None
Rattus norvegicus Solute carrier family 22 member 6 IC50 450000.0 nM 10.1016/s0024-3205(02)01500-x
Rattus norvegicus Solute carrier family 22 member 7 IC50 3180000.0 nM 10.1016/s0014-2999(03)01381-5
Rattus norvegicus Solute carrier family 22 member 8 IC50 90000.0 nM 10.1016/s0024-3205(02)01500-x
Salmonella enterica Salmonella enterica MIC 0.063 ug.mL-1 10.1128/aac.00371-09
Salmonella enterica Salmonella enterica MIC 0.25 ug.mL-1 10.1128/aac.00371-09
Salmonella enterica Salmonella enterica MIC 0.5 ug.mL-1 10.1128/aac.00371-09
Salmonella enterica Salmonella enterica MIC 1.0 ug.mL-1 10.1128/aac.00371-09
Salmonella enterica subsp. enterica serovar Typhimurium Salmonella typhimurium MIC 2.0 ug.mL-1 10.1128/aac.00079-09
Salmonella enterica subsp. enterica serovar Typhimurium Salmonella typhimurium MIC 64.0 ug.mL-1 10.1128/aac.00079-09
Salmonella enterica subsp. enterica serovar Typhimurium Salmonella typhimurium MIC 256.0 ug.mL-1 10.1128/aac.00079-09
Serratia Serratia MIC 100.0 ug.mL-1 10.1021/jm00214a018
Serratia marcescens Serratia marcescens MIC 50.0 ug.mL-1 10.1021/jm00193a001
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 IC50 19952.62 nM 10.6019/CHEMBL4651402
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 IC50 20000.0 nM 10.6019/CHEMBL4651402
Staphylococcus Staphylococcus Activity nan None 10.1128/aac.00275-10
Staphylococcus Staphylococcus FC 1.2 None 10.1128/aac.00275-10
Staphylococcus Staphylococcus FC 2.0 None 10.1128/aac.00275-10
Staphylococcus Staphylococcus MIC 0.00025 ug.mL-1 10.1128/aac.00275-10
Staphylococcus Staphylococcus MIC 0.001 ug.mL-1 10.1128/aac.00275-10
Staphylococcus Staphylococcus Ratio 0.62 None 10.1128/aac.00275-10
Staphylococcus Staphylococcus Ratio 0.63 None 10.1128/aac.00275-10
Staphylococcus Staphylococcus Ratio 0.65 None 10.1128/aac.00275-10
Staphylococcus Staphylococcus Ratio 0.86 None 10.1128/aac.00275-10
Staphylococcus Staphylococcus Ratio 1.06 None 10.1128/aac.00275-10
Staphylococcus Staphylococcus Ratio 1.07 None 10.1128/aac.00275-10
Staphylococcus Staphylococcus Ratio 1.12 None 10.1128/aac.00275-10
Staphylococcus Staphylococcus Ratio 1.27 None 10.1128/aac.00275-10
Staphylococcus Staphylococcus Ratio 1.29 None 10.1128/aac.00275-10
Staphylococcus aureus Staphylococcus aureus MIC 0.00025 ug.mL-1 10.1128/aac.00275-10
Staphylococcus aureus Staphylococcus aureus MIC 0.0005 ug.mL-1 10.1128/aac.00275-10
Staphylococcus aureus Staphylococcus aureus MIC 0.001 ug.mL-1 10.1128/aac.00275-10
Staphylococcus aureus Staphylococcus aureus MIC 0.1 ug.mL-1 10.1021/jm00193a001
Staphylococcus aureus Staphylococcus aureus MIC 0.39 ug.mL-1 10.1021/jm00214a018
Staphylococcus aureus Staphylococcus aureus MIC 0.4 ug.mL-1 10.1021/jm00193a001
Staphylococcus aureus Staphylococcus aureus MIC 0.4 ug.mL-1 10.1128/aac.00317-09
Staphylococcus aureus Staphylococcus aureus MIC 0.5 ug.mL-1 10.1128/aac.00317-09
Staphylococcus aureus Staphylococcus aureus MIC 0.6 ug.mL-1 10.1128/aac.00317-09
Staphylococcus aureus Staphylococcus aureus MIC 1.0 ug.mL-1 10.1128/aac.00317-09
Staphylococcus aureus Staphylococcus aureus MIC 1.3 ug.mL-1 10.1128/aac.00317-09
Staphylococcus aureus Staphylococcus aureus MIC 8.0 ug.mL-1 10.1128/aac.00317-09
Staphylococcus aureus Staphylococcus aureus MIC 13.6 ug.mL-1 10.1128/aac.00317-09
Staphylococcus aureus Staphylococcus aureus MIC 32.0 ug.mL-1 10.1128/aac.00317-09
Staphylococcus aureus Staphylococcus aureus MIC50 1.0 ug.mL-1 10.1128/aac.00317-09
Staphylococcus aureus Staphylococcus aureus MIC50 2.0 ug.mL-1 10.1128/aac.00317-09
Staphylococcus aureus Staphylococcus aureus MIC50 4.0 ug.mL-1 10.1128/aac.00317-09
Staphylococcus aureus Staphylococcus aureus MIC50 8.0 ug.mL-1 10.1128/aac.00317-09
Staphylococcus aureus Staphylococcus aureus MIC50 16.0 ug.mL-1 10.1128/aac.00317-09
Staphylococcus aureus Staphylococcus aureus MIC90 1.0 ug.mL-1 10.1128/aac.00317-09
Staphylococcus aureus Staphylococcus aureus MIC90 2.0 ug.mL-1 10.1128/aac.00317-09
Staphylococcus aureus Staphylococcus aureus MIC90 4.0 ug.mL-1 10.1128/aac.00317-09
Staphylococcus aureus Staphylococcus aureus MIC90 32.0 ug.mL-1 10.1128/aac.00317-09
Staphylococcus aureus Staphylococcus aureus MIC90 64.0 ug.mL-1 10.1128/aac.00317-09
Staphylococcus epidermidis Staphylococcus epidermidis MIC 0.00025 ug.mL-1 10.1128/aac.00275-10
Staphylococcus epidermidis Staphylococcus epidermidis MIC 0.0005 ug.mL-1 10.1128/aac.00275-10
Staphylococcus epidermidis Staphylococcus epidermidis MIC 0.002 ug.mL-1 10.1128/aac.00275-10
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.1 ug.mL-1 10.1021/jm00193a001
Streptococcus pyogenes Streptococcus pyogenes MIC 0.39 ug.mL-1 10.1021/jm00214a018
None ADMET CL 3.6 mL.min-1.kg-1 10.1124/dmd.108.020479
None ADMET Drug excretion 0.4 % 10.1124/dmd.112.049312
None ADMET Drug excretion 33.0 % 10.1124/dmd.112.049312
None ADMET MRT 0.75 hr 10.1124/dmd.108.020479
None ADMET T1/2 0.75 hr 10.1124/dmd.108.020479
None ADMET Vdss 0.16 L.kg-1 10.1124/dmd.108.020479
None Hepatotoxicity Alkaline Phosphatase Increase - Activity Score nan None 10.2174/1570163043334794
None Hepatotoxicity Alkaline Phosphatase Increase - Index Value 0.0 None 10.2174/1570163043334794
None Hepatotoxicity Alkaline Phosphatase Increase - Number of Reports 4.0 None 10.2174/1570163043334794
None Hepatotoxicity Composite Activity - Active 0.0 None 10.2174/1570163043334794
None Hepatotoxicity Composite Activity - Marginal 0.0 None 10.2174/1570163043334794
None Hepatotoxicity Composite Activity - Score nan None 10.2174/1570163043334794
None Hepatotoxicity GGT Increase - Activity Score nan None 10.2174/1570163043334794
None Hepatotoxicity GGT Increase - Index Value 0.0 None 10.2174/1570163043334794
None Hepatotoxicity GGT Increase - Number of Reports 4.0 None 10.2174/1570163043334794
None Hepatotoxicity LDH Increase - Activity Score nan None 10.2174/1570163043334794
None Hepatotoxicity LDH Increase - Index Value 0.0 None 10.2174/1570163043334794
None Hepatotoxicity LDH Increase - Number of Reports 4.0 None 10.2174/1570163043334794
None Hepatotoxicity SGOT Increase - Activity Score nan None 10.2174/1570163043334794
None Hepatotoxicity SGOT Increase - Index Value 0.0 None 10.2174/1570163043334794
None Hepatotoxicity SGOT Increase - Number of Reports 4.0 None 10.2174/1570163043334794
None Hepatotoxicity SGPT Increase - Activity Score nan None 10.2174/1570163043334794
None Hepatotoxicity SGPT Increase - Index Value 0.0 None 10.2174/1570163043334794
None Hepatotoxicity SGPT Increase - Number of Reports 4.0 None 10.2174/1570163043334794
None NON-PROTEIN TARGET Activity nan None 10.1128/aac.00427-09
None NON-PROTEIN TARGET Fu 0.25 None 10.1124/dmd.108.020479
None NON-PROTEIN TARGET Hepatotoxicity (acute) 2.4 % 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (animal toxicity known) nan None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (benign tumour) 0.0 None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (granulomatous hepatitis) 0.0 None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (mechanism) nan None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (moderate) 13.0 None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (moderate) 75.0 % 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (time to onset) nan None 10.1016/s0399-8320(04)95062-2
None No relevant target pKa 3.4 None 10.1007/s11095-013-1232-z
None No relevant target pKa_A1 3.29 None 10.6019/CHEMBL3301361
None Unchecked Hepatotoxicity (acute) 2.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (association with vascular disease) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (choleostasis) 1.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (chronic liver disease) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (cirrhosis) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (comment) nan None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (cytolytic) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (malignant tumour) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (severe hepatitis) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (steatosis) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (successful reintroduction) nan None 10.1016/s0399-8320(04)95062-2

Metabolism Information