Molecule

cinnamycin

AlkaPlorer ID: AK017706

Synonym: 'lanthiopeptin', 'Lanthiopeptin', 'Ro-09-0198', 'Cinnamycin', 'NSC-71936', 'NSC 71936', 'L-cysteinyl-L-arginyl-L-glutaminyl-D-cysteinyl-L-cysteinyl-3-aminoalanyl-L-phenylalanylglycyl-L-prolyl-L-phenylalanyl-(2S,3S)-2-amino-3-mercaptobutanoyl-L-phenylalanyl-L-valyl-L-cysteinyl-(3R)-3-hydroxy-L-a-aspartylglycyl-L-asparaginyl-(2S,3S)-2-amino-3-mercaptobutanoyl-L-lysine,cyclic (1->18),(4->14),(5->11)-tris(thioether),cyclic (6->19)-imine', 'Ro 09-0198', 'Ro 09‐0198'

IUPAC Name: (4S,16S,22S,25S,37S,41R,44R,47S,50S,65S)-44-amino-4,16,22-tribenzyl-47-(3-carbamimidamidopropyl)-31-[(R)-carboxy(hydroxy)methyl]-2,5,14,17,20,23,26,29,32,35,38,45,48,51,54,57,67-heptadecahydroxy-37-(2-hydroxy-2-iminoethyl)-50-(3-hydroxy-3-iminopropyl)-41,70-dimethyl-8-oxo-25-propan-2-yl-42,69,72-trithia-3,6,9,15,18,21,24,27,30,33,36,39,46,49,52,55,58,60,66-nonadecazapentacyclo[38.18.9.319,56.328,53.09,13]triheptaconta-2,5,14,17,20,23,26,29,32,35,38,45,48,51,54,57,66-heptadecaene-65-carboxylic acid

Structure

SMILES: CC1SCC2N=C(O)C3CSCC4N=C(O)[C@H](C(C)C)N=C(O)[C@H](CC5=CC=CC=C5)N=C(O)C1N=C(O)[C@H](CC1=CC=CC=C1)N=C(O)C1CCCN1C(=O)CN=C(O)[C@H](CC1=CC=CC=C1)N=C(O)C(CNCCCC[C@@H](C(=O)O)N=C(O)C(N=C(O)[C@H](CC(=N)O)N=C(O)CN=C(O)C([C@@H](O)C(=O)O)N=C4O)[C@@H](C)SC[C@H](N)C(O)=N[C@@H](CCCNC(=N)N)C(O)=N[C@@H](CCC(=N)O)C(O)=N3)N=C2O

InChI: InChI=1S/C89H125N25O25S3/c1-43(2)66-84(133)109-59-41-140-40-58-79(128)108-60-42-142-45(4)68(86(135)105-55(75(124)110-66)34-48-22-12-7-13-23-48)111-76(125)54(33-47-20-10-6-11-21-47)104-82(131)61-26-17-31-114(61)65(118)38-98-72(121)53(32-46-18-8-5-9-19-46)103-78(127)57(106-80(60)129)36-95-29-15-14-24-52(87(136)137)102-85(134)67(112-77(126)56(35-63(92)116)99-64(117)37-97-83(132)69(113-81(59)130)70(119)88(138)139)44(3)141-39-49(90)71(120)100-50(25-16-30-96-89(93)94)73(122)101-51(74(123)107-58)27-28-62(91)115/h5-13,18-23,43-45,49-61,66-70,95,119H,14-17,24-42,90H2,1-4H3,(H2,91,115)(H2,92,116)(H,97,132)(H,98,121)(H,99,117)(H,100,120)(H,101,122)(H,102,134)(H,103,127)(H,104,131)(H,105,135)(H,106,129)(H,107,123)(H,108,128)(H,109,133)(H,110,124)(H,111,125)(H,112,126)(H,113,130)(H,136,137)(H,138,139)(H4,93,94,96)/t44-,45?,49+,50+,51+,52+,53+,54+,55+,56+,57?,58?,59?,60?,61?,66+,67?,68?,69?,70-/m1/s1

InChIKey: QJDWKBINWOWJNZ-GHIWXMCHSA-N

Reference

Cloning and engineering of the cinnamycin biosynthetic gene cluster from <i>Streptomyces cinnamoneus cinnamoneus</i> DSM 40005

PubChem CID: 162857273

LOTUS: LTS0040342

Source

Species	Genus	Family	Order	Class	Phylum	Kingdom	Domain
Streptomyces longisporoflavus	Streptomyces	Streptomycetaceae	Kitasatosporales	Actinomycetes	Actinomycetota	None	Bacteria

Properties Information

Molecule Weight: 2041.330000000002

TPSA？: 857.2800000000003

MolLogP？: 6.30340999999999

Number of H-Donors: 29

Number of H-Acceptors: 29

RingCount: 8

Activities Information

Organism	Target Name	Standard Type	Standard Value	Standard Units	doi