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name Structure Reference Source Properties Activities Metabolism

9-[2-(tert-butylamino)acetamido]-4,7-bis(dimethylamino)-3,10,12,12a-tetrahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide

AlkaPlorer ID: AK017969

Synonym: None

IUPAC Name: (4S,4aS,5aR,12aR)-9-[[2-(tert-butylamino)acetyl]amino]-4,7-bis(dimethylamino)-1,10,11,12a-tetrahydroxy-3,12-dioxo-4a,5,5a,6-tetrahydro-4H-tetracene-2-carboxamide

Structure

SMILES: CN(C)C1=C2C[C@H]3C[C@H]4[C@H](N(C)C)C(O)=C(C(=N)O)C(=O)[C@@]4(O)C(O)=C3C(=O)C2=C(O)C(N=C(O)CNC(C)(C)C)=C1

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InChI: InChI=1S/C29H39N5O8/c1-28(2,3)31-11-17(35)32-15-10-16(33(4)5)13-8-12-9-14-21(34(6)7)24(38)20(27(30)41)26(40)29(14,42)25(39)18(12)23(37)19(13)22(15)36/h10,12,14,21,31,36,38-39,42H,8-9,11H2,1-7H3,(H2,30,41)(H,32,35)/t12-,14-,21-,29-/m0/s1

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InChIKey: FPZLLRFZJZRHSY-HJYUBDRYSA-N

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Source

Species Genus Family Order Class Phylum Kingdom Domain
Apis cerana Apis Apidae Hymenoptera Insecta Arthropoda Metazoa Eukaryota

Properties Information

Molecule Weight: 585.6580000000002

TPSA？: 210.24

MolLogP？: 2.212670000000002

Number of H-Donors: 8

Number of H-Acceptors: 11

RingCount: 4

Activities Information

Organism Target Name Standard Type Standard Value Standard Units doi
Acinetobacter Acinetobacter MIC 0.12 ug.mL-1 10.1128/aac.01115-07
Acinetobacter Acinetobacter MIC 2.0 ug.mL-1 10.1128/aac.01115-07
Acinetobacter baumannii Acinetobacter baumannii Activity -1.2 log10CFU/g 10.1016/j.bmcl.2022.128648
Acinetobacter baumannii Acinetobacter baumannii Activity 4.2 log10CFU/g 10.1016/j.bmcl.2022.128648
Acinetobacter baumannii Acinetobacter baumannii Activity 20.0 % 10.1021/acsmedchemlett.9b00135
Acinetobacter baumannii Acinetobacter baumannii Activity 88.0 % 10.1128/aac.01099-06
Acinetobacter baumannii Acinetobacter baumannii Activity 100.0 % 10.1021/acs.jmedchem.2c01905
Acinetobacter baumannii Acinetobacter baumannii Activity nan None 10.1128/aac.00893-06
Acinetobacter baumannii Acinetobacter baumannii Activity nan None 10.1128/aac.01099-06
Acinetobacter baumannii Acinetobacter baumannii Activity nan None 10.1128/aac.01581-07
Acinetobacter baumannii Acinetobacter baumannii ED90 6.25 mg kg-1 10.1021/acs.jmedchem.8b00091
Acinetobacter baumannii Acinetobacter baumannii log10cfu 1.5 None 10.1128/aac.00647-08
Acinetobacter baumannii Acinetobacter baumannii log10cfu 2.0 None 10.1128/aac.00647-08
Acinetobacter baumannii Acinetobacter baumannii log10cfu 3.5 None 10.1128/aac.00647-08
Acinetobacter baumannii Acinetobacter baumannii MIC 0.03 ug.mL-1 10.1128/aac.01097-08
Acinetobacter baumannii Acinetobacter baumannii MIC 0.047 ug.mL-1 10.1128/aac.00732-07
Acinetobacter baumannii Acinetobacter baumannii MIC 0.06 ug.mL-1 10.1128/aac.00484-10
Acinetobacter baumannii Acinetobacter baumannii MIC 0.06 ug.mL-1 10.1128/aac.01581-07
Acinetobacter baumannii Acinetobacter baumannii MIC 0.09 ug.mL-1 10.1128/aac.01684-07
Acinetobacter baumannii Acinetobacter baumannii MIC 0.094 ug.mL-1 10.1128/aac.01037-09
Acinetobacter baumannii Acinetobacter baumannii MIC 0.12 ug.mL-1 10.1128/aac.01122-08
Acinetobacter baumannii Acinetobacter baumannii MIC 0.12 ug.mL-1 10.1128/aac.01197-09
Acinetobacter baumannii Acinetobacter baumannii MIC 0.12 ug.mL-1 10.1128/aac.01581-07
Acinetobacter baumannii Acinetobacter baumannii MIC 0.125 ug.mL-1 10.1128/aac.01037-09
Acinetobacter baumannii Acinetobacter baumannii MIC 0.125 ug.mL-1 10.1128/aac.01198-06
Acinetobacter baumannii Acinetobacter baumannii MIC 0.19 ug.mL-1 10.1128/aac.01684-07
Acinetobacter baumannii Acinetobacter baumannii MIC 0.25 ug.mL-1 10.1021/jm1015395
Acinetobacter baumannii Acinetobacter baumannii MIC 0.25 ug.mL-1 10.1128/aac.00484-10
Acinetobacter baumannii Acinetobacter baumannii MIC 0.25 ug.mL-1 10.1128/aac.01084-06
Acinetobacter baumannii Acinetobacter baumannii MIC 0.25 ug.mL-1 10.1128/aac.01097-08
Acinetobacter baumannii Acinetobacter baumannii MIC 0.25 ug.mL-1 10.1128/aac.01684-07
Acinetobacter baumannii Acinetobacter baumannii MIC 0.38 ug.mL-1 10.1128/aac.01037-09
Acinetobacter baumannii Acinetobacter baumannii MIC 0.5 ug.mL-1 10.1021/jm201465w
Acinetobacter baumannii Acinetobacter baumannii MIC 0.5 ug.mL-1 10.1128/aac.00732-07
Acinetobacter baumannii Acinetobacter baumannii MIC 0.5 ug.mL-1 10.1128/aac.01037-09
Acinetobacter baumannii Acinetobacter baumannii MIC 0.5 ug.mL-1 10.1128/aac.01097-08
Acinetobacter baumannii Acinetobacter baumannii MIC 0.5 ug.mL-1 10.1128/aac.01684-07
Acinetobacter baumannii Acinetobacter baumannii MIC 0.75 ug.mL-1 10.1128/aac.01684-07
Acinetobacter baumannii Acinetobacter baumannii MIC 1.0 ug.mL-1 10.1021/acs.jmedchem.9b00720
Acinetobacter baumannii Acinetobacter baumannii MIC 1.0 ug.mL-1 10.1128/aac.00178-09
Acinetobacter baumannii Acinetobacter baumannii MIC 1.0 ug.mL-1 10.1128/aac.00414-10
Acinetobacter baumannii Acinetobacter baumannii MIC 1.0 ug.mL-1 10.1128/aac.01198-06
Acinetobacter baumannii Acinetobacter baumannii MIC 1.0 ug.mL-1 10.1128/aac.01684-07
Acinetobacter baumannii Acinetobacter baumannii MIC 1.5 ug.mL-1 10.1128/aac.00732-07
Acinetobacter baumannii Acinetobacter baumannii MIC 1.5 ug.mL-1 10.1128/aac.01037-09
Acinetobacter baumannii Acinetobacter baumannii MIC 1.5 ug.mL-1 10.1128/aac.01684-07
Acinetobacter baumannii Acinetobacter baumannii MIC 2.0 ug.mL-1 10.1128/aac.00414-10
Acinetobacter baumannii Acinetobacter baumannii MIC 2.0 ug.mL-1 10.1128/aac.00732-07
Acinetobacter baumannii Acinetobacter baumannii MIC 2.0 ug.mL-1 10.1128/aac.01122-08
Acinetobacter baumannii Acinetobacter baumannii MIC 2.0 ug.mL-1 10.1128/aac.01198-06
Acinetobacter baumannii Acinetobacter baumannii MIC 2.0 ug.mL-1 10.1128/aac.01684-07
Acinetobacter baumannii Acinetobacter baumannii MIC 3.0 ug.mL-1 10.1128/aac.00414-10
Acinetobacter baumannii Acinetobacter baumannii MIC 3.0 ug.mL-1 10.1128/aac.00732-07
Acinetobacter baumannii Acinetobacter baumannii MIC 3.0 ug.mL-1 10.1128/aac.01037-09
Acinetobacter baumannii Acinetobacter baumannii MIC 3.0 ug.mL-1 10.1128/aac.01684-07
Acinetobacter baumannii Acinetobacter baumannii MIC 4.0 ug.mL-1 10.1021/acs.jmedchem.8b00091
Acinetobacter baumannii Acinetobacter baumannii MIC 4.0 ug.mL-1 10.1128/aac.00178-09
Acinetobacter baumannii Acinetobacter baumannii MIC 4.0 ug.mL-1 10.1128/aac.00414-10
Acinetobacter baumannii Acinetobacter baumannii MIC 4.0 ug.mL-1 10.1128/aac.00732-07
Acinetobacter baumannii Acinetobacter baumannii MIC 4.0 ug.mL-1 10.1128/aac.01198-06
Acinetobacter baumannii Acinetobacter baumannii MIC 4.0 ug.mL-1 10.1128/aac.01581-07
Acinetobacter baumannii Acinetobacter baumannii MIC 6.0 ug.mL-1 10.1128/aac.00414-10
Acinetobacter baumannii Acinetobacter baumannii MIC 6.0 ug.mL-1 10.1128/aac.01121-08
Acinetobacter baumannii Acinetobacter baumannii MIC 6.0 ug.mL-1 10.1128/aac.01198-06
Acinetobacter baumannii Acinetobacter baumannii MIC 8.0 ug.mL-1 10.1021/acs.jmedchem.5b00262
Acinetobacter baumannii Acinetobacter baumannii MIC 8.0 ug.mL-1 10.1021/acs.jmedchem.6b01903
Acinetobacter baumannii Acinetobacter baumannii MIC 8.0 ug.mL-1 10.1128/aac.00414-10
Acinetobacter baumannii Acinetobacter baumannii MIC 12.0 ug.mL-1 10.1128/aac.00414-10
Acinetobacter baumannii Acinetobacter baumannii MIC 16.0 ug.mL-1 10.1021/acs.jmedchem.2c01905
Acinetobacter baumannii Acinetobacter baumannii MIC 16.0 ug.mL-1 10.1128/aac.00414-10
Acinetobacter baumannii Acinetobacter baumannii MIC 16.0 ug.mL-1 10.1128/aac.01198-06
Acinetobacter baumannii Acinetobacter baumannii MIC 24.0 ug.mL-1 10.1128/aac.01198-06
Acinetobacter baumannii Acinetobacter baumannii MIC 64.0 ug.mL-1 10.1128/aac.01581-07
Acinetobacter baumannii Acinetobacter baumannii MIC50 0.25 ug.mL-1 10.1128/aac.00484-10
Acinetobacter baumannii Acinetobacter baumannii MIC50 0.5 ug.mL-1 10.1128/aac.00484-10
Acinetobacter baumannii Acinetobacter baumannii MIC50 1.0 ug.mL-1 10.1128/aac.01097-08
Acinetobacter baumannii Acinetobacter baumannii MIC50 1.0 ug.mL-1 10.1128/aac.01099-06
Acinetobacter baumannii Acinetobacter baumannii MIC50 1.0 ug.mL-1 10.1128/aac.01197-09
Acinetobacter baumannii Acinetobacter baumannii MIC50 2.0 ug.mL-1 10.1128/aac.00414-10
Acinetobacter baumannii Acinetobacter baumannii MIC50 2.0 ug.mL-1 10.1128/aac.01581-07
Acinetobacter baumannii Acinetobacter baumannii MIC50 8.0 ug.mL-1 10.1128/aac.01581-07
Acinetobacter baumannii Acinetobacter baumannii MIC50 16.0 ug.mL-1 10.1128/aac.00414-10
Acinetobacter baumannii Acinetobacter baumannii MIC90 2.0 ug.mL-1 10.1128/aac.00484-10
Acinetobacter baumannii Acinetobacter baumannii MIC90 2.0 ug.mL-1 10.1128/aac.01097-08
Acinetobacter baumannii Acinetobacter baumannii MIC90 2.0 ug.mL-1 10.1128/aac.01099-06
Acinetobacter baumannii Acinetobacter baumannii MIC90 2.0 ug.mL-1 10.1128/aac.01197-09
Acinetobacter baumannii Acinetobacter baumannii MIC90 4.0 ug.mL-1 10.1128/aac.00414-10
Acinetobacter baumannii Acinetobacter baumannii MIC90 8.0 ug.mL-1 10.1128/aac.00484-10
Acinetobacter baumannii Acinetobacter baumannii MIC90 16.0 ug.mL-1 10.1021/acs.jmedchem.9b01605
Acinetobacter baumannii Acinetobacter baumannii MIC90 32.0 ug.mL-1 10.1128/aac.00414-10
Acinetobacter baumannii Acinetobacter baumannii PAE 0.3 hr 10.1128/aac.01122-08
Acinetobacter baumannii Acinetobacter baumannii PAE 0.4 hr 10.1128/aac.01122-08
Acinetobacter baumannii Acinetobacter baumannii PAE 0.7 hr 10.1128/aac.01122-08
Acinetobacter baumannii Acinetobacter baumannii PAE 1.2 hr 10.1128/aac.01122-08
Acinetobacter baumannii Acinetobacter baumannii PAE 1.3 hr 10.1128/aac.01122-08
Acinetobacter baumannii Acinetobacter baumannii PAE 1.5 hr 10.1128/aac.01122-08
Acinetobacter baumannii Acinetobacter baumannii PAE 1.8 hr 10.1128/aac.01122-08
Acinetobacter baumannii Acinetobacter baumannii PAE 1.9 hr 10.1128/aac.01122-08
Acinetobacter baumannii Acinetobacter baumannii PAE 2.2 hr 10.1128/aac.01122-08
Acinetobacter baumannii Acinetobacter baumannii PAE 2.9 hr 10.1128/aac.01122-08
Acinetobacter baumannii Acinetobacter baumannii PAE 3.0 hr 10.1128/aac.01122-08
Acinetobacter baumannii Acinetobacter baumannii PAE 3.8 hr 10.1128/aac.01122-08
Acinetobacter baumannii Acinetobacter baumannii PAE 5.2 hr 10.1128/aac.01122-08
Acinetobacter baumannii Acinetobacter baumannii PAE 6.7 hr 10.1128/aac.01122-08
Acinetobacter baumannii Acinetobacter baumannii PAE 10.7 hr 10.1128/aac.01122-08
Acinetobacter baumannii Acinetobacter baumannii PAE 11.2 hr 10.1128/aac.01122-08
Acinetobacter baumannii Acinetobacter baumannii PD50 6.25 mg kg-1 10.1021/acs.jmedchem.8b00091
Acinetobacter calcoaceticus Acinetobacter calcoaceticus MIC 0.25 ug.mL-1 10.1128/aac.01084-06
Acinetobacter calcoaceticus Acinetobacter calcoaceticus MIC 0.5 ug.mL-1 10.1016/j.ejmech.2018.03.031
Acinetobacter calcoaceticus Acinetobacter calcoaceticus MIC 1.0 ug.mL-1 10.1016/j.ejmech.2018.03.031
Acinetobacter haemolyticus Acinetobacter haemolyticus MIC 0.5 ug.mL-1 10.1128/aac.01084-06
Acinetobacter lwoffii Acinetobacter lwoffii MIC 2.0 ug.mL-1 10.1128/aac.00598-10
Acinetobacter lwoffii Acinetobacter lwoffii MIC 4.0 ug.mL-1 10.1128/aac.00598-10
Acinetobacter lwoffii Acinetobacter lwoffii MIC 8.0 ug.mL-1 10.1128/aac.00598-10
Acinetobacter lwoffii Acinetobacter lwoffii MIC 16.0 ug.mL-1 10.1128/aac.00598-10
Acinetobacter pittii Acinetobacter pittii Activity 0.0 % 10.1128/aac.01624-09
Acinetobacter pittii Acinetobacter pittii MIC 0.12 ug.mL-1 10.1128/aac.01624-09
Acinetobacter pittii Acinetobacter pittii MIC50 0.12 ug.mL-1 10.1128/aac.01624-09
Acinetobacter pittii Acinetobacter pittii MIC90 0.5 ug.mL-1 10.1128/aac.01624-09
Acinetobacter sp. Acinetobacter sp. MIC50 2.0 ug.mL-1 10.1128/aac.00572-10
Acinetobacter sp. Acinetobacter sp. MIC90 16.0 ug.mL-1 10.1128/aac.00572-10
Aeromonas caviae Aeromonas caviae Activity 0.0 % 10.1128/aac.00002-08
Aeromonas caviae Aeromonas caviae Activity 1.6 % 10.1128/aac.00002-08
Aeromonas caviae Aeromonas caviae Activity 96.8 % 10.1128/aac.00002-08
Aeromonas caviae Aeromonas caviae Activity 98.4 % 10.1128/aac.00002-08
Aeromonas hydrophila Aeromonas hydrophila Activity 0.0 % 10.1128/aac.00002-08
Aeromonas hydrophila Aeromonas hydrophila Activity 1.2 % 10.1128/aac.00002-08
Aeromonas hydrophila Aeromonas hydrophila Activity 98.8 % 10.1128/aac.00002-08
Aeromonas hydrophila Aeromonas hydrophila Activity 100.0 % 10.1128/aac.00002-08
Aeromonas sobria Aeromonas sobria Activity 0.0 % 10.1128/aac.00002-08
Aeromonas sobria Aeromonas sobria Activity 100.0 % 10.1128/aac.00002-08
Bacteroides caccae Bacteroides caccae Activity 7.2 % 10.1128/aac.01435-06
Bacteroides caccae Bacteroides caccae Activity 16.1 % 10.1128/aac.00081-08
Bacteroides caccae Bacteroides caccae MIC 0.125 ug.mL-1 10.1128/aac.00081-08
Bacteroides caccae Bacteroides caccae MIC 1.51 ug.mL-1 10.1128/aac.01435-06
Bacteroides caccae Bacteroides caccae MIC50 1.0 ug.mL-1 10.1128/aac.00081-08
Bacteroides caccae Bacteroides caccae MIC90 8.0 ug.mL-1 10.1128/aac.01435-06
Bacteroides caccae Bacteroides caccae MIC90 16.0 ug.mL-1 10.1128/aac.00081-08
Bacteroides fragilis Bacteroides fragilis Activity 5.1 % 10.1128/aac.01435-06
Bacteroides fragilis Bacteroides fragilis Activity 6.5 % 10.1128/aac.00081-08
Bacteroides fragilis Bacteroides fragilis MIC 0.06 ug.mL-1 10.1128/aac.00081-08
Bacteroides fragilis Bacteroides fragilis MIC 1.59 ug.mL-1 10.1128/aac.01435-06
Bacteroides fragilis Bacteroides fragilis MIC50 1.0 ug.mL-1 10.1128/aac.00081-08
Bacteroides fragilis Bacteroides fragilis MIC90 8.0 ug.mL-1 10.1128/aac.00081-08
Bacteroides fragilis Bacteroides fragilis MIC90 8.0 ug.mL-1 10.1128/aac.01435-06
Bacteroides ovatus Bacteroides ovatus Activity 3.3 % 10.1128/aac.01435-06
Bacteroides ovatus Bacteroides ovatus Activity 7.2 % 10.1128/aac.00081-08
Bacteroides ovatus Bacteroides ovatus MIC 0.125 ug.mL-1 10.1128/aac.00081-08
Bacteroides ovatus Bacteroides ovatus MIC 1.52 ug.mL-1 10.1128/aac.01435-06
Bacteroides ovatus Bacteroides ovatus MIC50 2.0 ug.mL-1 10.1128/aac.00081-08
Bacteroides ovatus Bacteroides ovatus MIC90 8.0 ug.mL-1 10.1128/aac.00081-08
Bacteroides ovatus Bacteroides ovatus MIC90 8.0 ug.mL-1 10.1128/aac.01435-06
Bacteroides sp. Bacteroides sp. Activity 10.5 % 10.1128/aac.00081-08
Bacteroides sp. Bacteroides sp. MIC 0.125 ug.mL-1 10.1128/aac.00081-08
Bacteroides sp. Bacteroides sp. MIC50 1.0 ug.mL-1 10.1128/aac.00081-08
Bacteroides sp. Bacteroides sp. MIC90 8.0 ug.mL-1 10.1128/aac.00081-08
Bacteroides stercoris Bacteroides stercoris Activity 7.2 % 10.1128/aac.01435-06
Bacteroides stercoris Bacteroides stercoris Activity 10.5 % 10.1128/aac.00081-08
Bacteroides stercoris Bacteroides stercoris MIC 0.125 ug.mL-1 10.1128/aac.00081-08
Bacteroides stercoris Bacteroides stercoris MIC 1.51 ug.mL-1 10.1128/aac.01435-06
Bacteroides stercoris Bacteroides stercoris MIC50 1.0 ug.mL-1 10.1128/aac.00081-08
Bacteroides stercoris Bacteroides stercoris MIC90 8.0 ug.mL-1 10.1128/aac.00081-08
Bacteroides stercoris Bacteroides stercoris MIC90 8.0 ug.mL-1 10.1128/aac.01435-06
Bacteroides thetaiotaomicron Bacteroides thetaiotaomicron Activity 3.6 % 10.1128/aac.01435-06
Bacteroides thetaiotaomicron Bacteroides thetaiotaomicron Activity 7.5 % 10.1128/aac.00081-08
Bacteroides thetaiotaomicron Bacteroides thetaiotaomicron MIC 0.06 ug.mL-1 10.1128/aac.00081-08
Bacteroides thetaiotaomicron Bacteroides thetaiotaomicron MIC 1.57 ug.mL-1 10.1128/aac.01435-06
Bacteroides thetaiotaomicron Bacteroides thetaiotaomicron MIC50 1.0 ug.mL-1 10.1128/aac.00081-08
Bacteroides thetaiotaomicron Bacteroides thetaiotaomicron MIC90 8.0 ug.mL-1 10.1128/aac.00081-08
Bacteroides thetaiotaomicron Bacteroides thetaiotaomicron MIC90 8.0 ug.mL-1 10.1128/aac.01435-06
Bacteroides uniformis Bacteroides uniformis Activity 3.4 % 10.1128/aac.01435-06
Bacteroides uniformis Bacteroides uniformis Activity 9.1 % 10.1128/aac.00081-08
Bacteroides uniformis Bacteroides uniformis MIC 0.06 ug.mL-1 10.1128/aac.00081-08
Bacteroides uniformis Bacteroides uniformis MIC 0.77 ug.mL-1 10.1128/aac.01435-06
Bacteroides uniformis Bacteroides uniformis MIC50 1.0 ug.mL-1 10.1128/aac.00081-08
Bacteroides uniformis Bacteroides uniformis MIC90 4.0 ug.mL-1 10.1128/aac.01435-06
Bacteroides uniformis Bacteroides uniformis MIC90 8.0 ug.mL-1 10.1128/aac.00081-08
Burkholderia cenocepacia Burkholderia cenocepacia MIC 16.0 ug.mL-1 10.1021/acs.jmedchem.5b00262
Burkholderia cenocepacia Burkholderia cenocepacia MIC 16.0 ug.mL-1 10.1021/acs.jmedchem.6b01903
Burkholderia cepacia Burkholderia cepacia MIC 0.06 ug.mL-1 10.1128/aac.00484-10
Burkholderia cepacia Burkholderia cepacia MIC50 8.0 ug.mL-1 10.1128/aac.00484-10
Burkholderia cepacia Burkholderia cepacia MIC90 8.0 ug.mL-1 10.1128/aac.00484-10
Burkholderia cepacia Burkholderia cepacia MIC90 16.0 ug.mL-1 10.1021/acs.jmedchem.9b01605
Campylobacter coli Campylobacter coli Activity 0.0 % 10.1128/aac.00898-09
Campylobacter jejuni Campylobacter jejuni Activity 0.0 % 10.1128/aac.00898-09
Chlorocebus sabaeus Vero Activity nan None 10.1128/aac.01424-08
Citrobacter Citrobacter MIC50 0.5 ug.mL-1 10.1128/aac.00572-10
Citrobacter freundii Citrobacter freundii MIC 0.12 ug.mL-1 10.1128/aac.01114-07
Citrobacter freundii Citrobacter freundii MIC 0.13 ug.mL-1 10.1128/aac.01099-09
Citrobacter freundii Citrobacter freundii MIC 0.25 ug.mL-1 10.1128/aac.01114-07
Citrobacter freundii Citrobacter freundii MIC 0.25 ug.mL-1 10.1128/aac.01197-09
Citrobacter freundii Citrobacter freundii MIC 0.5 ug.mL-1 10.1128/aac.01084-06
Citrobacter freundii Citrobacter freundii MIC 0.5 ug.mL-1 10.1128/aac.01405-06
Citrobacter freundii Citrobacter freundii MIC 1.0 ug.mL-1 10.1128/aac.01099-09
Citrobacter freundii Citrobacter freundii MIC 1.0 ug.mL-1 10.1128/aac.01114-07
Citrobacter freundii Citrobacter freundii MIC50 0.25 ug.mL-1 10.1128/aac.01197-09
Citrobacter freundii Citrobacter freundii MIC90 0.5 ug.mL-1 10.1128/aac.01197-09
Citrobacter freundii Citrobacter freundii MIC90 1.0 ug.mL-1 10.1021/acs.jmedchem.9b01605
Citrobacter koseri Citrobacter koseri MIC 0.5 ug.mL-1 10.1128/aac.01084-06
Clostridioides difficile Clostridioides difficile MIC50 0.125 ug.mL-1 10.1128/aac.01623-06
Clostridioides difficile Clostridioides difficile MIC90 0.25 ug.mL-1 10.1128/aac.01623-06
Corynebacterium amycolatum Corynebacterium amycolatum MIC 0.015 ug.mL-1 10.1128/aac.01129-07
Corynebacterium amycolatum Corynebacterium amycolatum MIC50 0.125 ug.mL-1 10.1128/aac.01129-07
Corynebacterium amycolatum Corynebacterium amycolatum MIC90 0.25 ug.mL-1 10.1128/aac.01129-07
Corynebacterium jeikeium Corynebacterium jeikeium MIC 0.015 ug.mL-1 10.1128/aac.01129-07
Corynebacterium jeikeium Corynebacterium jeikeium MIC50 0.015 ug.mL-1 10.1128/aac.01129-07
Corynebacterium jeikeium Corynebacterium jeikeium MIC90 0.03 ug.mL-1 10.1128/aac.01129-07
Corynebacterium minutissimum Corynebacterium minutissimum MIC 0.003 ug.mL-1 10.1128/aac.01129-07
Corynebacterium minutissimum Corynebacterium minutissimum MIC50 0.015 ug.mL-1 10.1128/aac.01129-07
Corynebacterium pseudodiphtheriticum Corynebacterium pseudodiphtheriticum MIC 0.015 ug.mL-1 10.1128/aac.01129-07
Corynebacterium pseudodiphtheriticum Corynebacterium pseudodiphtheriticum MIC50 0.015 ug.mL-1 10.1128/aac.01129-07
Corynebacterium pseudodiphtheriticum Corynebacterium pseudodiphtheriticum MIC90 0.03 ug.mL-1 10.1128/aac.01129-07
Corynebacterium striatum Corynebacterium striatum MIC 0.015 ug.mL-1 10.1128/aac.01129-07
Corynebacterium striatum Corynebacterium striatum MIC50 0.5 ug.mL-1 10.1128/aac.01129-07
Corynebacterium striatum Corynebacterium striatum MIC90 1.0 ug.mL-1 10.1128/aac.01129-07
Corynebacterium urealyticum Corynebacterium urealyticum MIC 0.015 ug.mL-1 10.1128/aac.01129-07
Corynebacterium urealyticum Corynebacterium urealyticum MIC50 0.03 ug.mL-1 10.1128/aac.01129-07
Corynebacterium urealyticum Corynebacterium urealyticum MIC90 0.06 ug.mL-1 10.1128/aac.01129-07
Corynebacterium xerosis Corynebacterium xerosis MIC 0.015 ug.mL-1 10.1128/aac.01129-07
Corynebacterium xerosis Corynebacterium xerosis MIC50 0.125 ug.mL-1 10.1128/aac.01129-07
Coxiella burnetii Coxiella burnetii Activity nan None 10.1128/aac.01424-08
Coxiella burnetii Coxiella burnetii MIC 0.06 ug.mL-1 10.1128/aac.01424-08
Coxiella burnetii Coxiella burnetii MIC 0.125 ug.mL-1 10.1128/aac.01424-08
Coxiella burnetii Coxiella burnetii MIC 0.25 ug.mL-1 10.1128/aac.01424-08
Coxiella burnetii Coxiella burnetii MIC 0.5 ug.mL-1 10.1128/aac.01424-08
Enterobacter cloacae Enterobacter cloacae Activity 0.0 % 10.1128/aac.01538-07
Enterobacter cloacae Enterobacter cloacae Activity 0.6 % 10.1128/aac.01538-07
Enterobacter cloacae Enterobacter cloacae Activity 6.3 % 10.1128/aac.01538-07
Enterobacter cloacae Enterobacter cloacae Inhibition nan % 10.1128/aac.01452-08
Enterobacter cloacae Enterobacter cloacae MBC 0.5 ug ml-1 10.1128/aac.01452-08
Enterobacter cloacae Enterobacter cloacae MBC 2.0 ug ml-1 10.1128/aac.01452-08
Enterobacter cloacae Enterobacter cloacae MIC 0.064 ug.mL-1 10.1128/aac.00072-07
Enterobacter cloacae Enterobacter cloacae MIC 0.12 ug.mL-1 10.1128/aac.01114-07
Enterobacter cloacae Enterobacter cloacae MIC 0.125 ug.mL-1 10.1128/aac.00072-07
Enterobacter cloacae Enterobacter cloacae MIC 0.19 ug.mL-1 10.1128/aac.00072-07
Enterobacter cloacae Enterobacter cloacae MIC 0.25 ug.mL-1 10.1021/jm1015395
Enterobacter cloacae Enterobacter cloacae MIC 0.25 ug.mL-1 10.1021/jm201465w
Enterobacter cloacae Enterobacter cloacae MIC 0.25 ug.mL-1 10.1128/aac.01114-07
Enterobacter cloacae Enterobacter cloacae MIC 0.25 ug.mL-1 10.1128/aac.01197-09
Enterobacter cloacae Enterobacter cloacae MIC 0.25 ug.mL-1 10.1128/aac.01452-08
Enterobacter cloacae Enterobacter cloacae MIC 0.38 ug.mL-1 10.1128/aac.00072-07
Enterobacter cloacae Enterobacter cloacae MIC 0.5 ug.mL-1 10.1128/aac.00072-07
Enterobacter cloacae Enterobacter cloacae MIC 0.5 ug.mL-1 10.1128/aac.01099-09
Enterobacter cloacae Enterobacter cloacae MIC 0.5 ug.mL-1 10.1128/aac.01114-07
Enterobacter cloacae Enterobacter cloacae MIC 0.5 ug.mL-1 10.1128/aac.01122-08
Enterobacter cloacae Enterobacter cloacae MIC 0.5 ug.mL-1 10.1128/aac.01452-08
Enterobacter cloacae Enterobacter cloacae MIC 0.75 ug.mL-1 10.1128/aac.00072-07
Enterobacter cloacae Enterobacter cloacae MIC 1.0 ug.mL-1 10.1016/j.ejmech.2018.03.031
Enterobacter cloacae Enterobacter cloacae MIC 1.0 ug.mL-1 10.1128/aac.01084-06
Enterobacter cloacae Enterobacter cloacae MIC 1.0 ug.mL-1 10.1128/aac.01099-09
Enterobacter cloacae Enterobacter cloacae MIC 1.0 ug.mL-1 10.1128/aac.01592-08
Enterobacter cloacae Enterobacter cloacae MIC 2.0 ug.mL-1 10.1128/aac.00260-09
Enterobacter cloacae Enterobacter cloacae MIC 2.0 ug.mL-1 10.1128/aac.01592-08
Enterobacter cloacae Enterobacter cloacae MIC 3.0 ug.mL-1 10.1128/aac.01592-08
Enterobacter cloacae Enterobacter cloacae MIC 4.0 ug.mL-1 10.1021/acs.jmedchem.5b00262
Enterobacter cloacae Enterobacter cloacae MIC 4.0 ug.mL-1 10.1021/acs.jmedchem.6b01903
Enterobacter cloacae Enterobacter cloacae MIC 4.0 ug.mL-1 10.1128/aac.01099-09
Enterobacter cloacae Enterobacter cloacae MIC 4.0 ug.mL-1 10.1128/aac.01592-08
Enterobacter cloacae Enterobacter cloacae MIC 8.0 ug.mL-1 10.1016/j.ejmech.2018.03.031
Enterobacter cloacae Enterobacter cloacae MIC50 0.5 ug.mL-1 10.1128/aac.01197-09
Enterobacter cloacae Enterobacter cloacae MIC90 2.0 ug.mL-1 10.1128/aac.01197-09
Enterobacter cloacae Enterobacter cloacae MIC90 4.0 ug.mL-1 10.1021/acs.jmedchem.9b01605
Enterobacter cloacae Enterobacter cloacae PAE 0.2 hr 10.1128/aac.01122-08
Enterobacter cloacae Enterobacter cloacae PAE 0.4 hr 10.1128/aac.01122-08
Enterobacter cloacae Enterobacter cloacae PAE 1.0 hr 10.1128/aac.01122-08
Enterobacter cloacae Enterobacter cloacae PAE 1.2 hr 10.1128/aac.01122-08
Enterobacter cloacae Enterobacter cloacae PAE 2.0 hr 10.1128/aac.01122-08
Enterobacter cloacae Enterobacter cloacae PAE 2.7 hr 10.1128/aac.01122-08
Enterobacter cloacae Enterobacter cloacae PAE 2.9 hr 10.1128/aac.01122-08
Enterobacter cloacae Enterobacter cloacae PAE 3.6 hr 10.1128/aac.01122-08
Enterobacter cloacae Enterobacter cloacae PAE 4.9 hr 10.1128/aac.01122-08
Enterobacter cloacae Enterobacter cloacae PAE 5.0 hr 10.1128/aac.01122-08
Enterobacter cloacae Enterobacter cloacae PAE 6.9 hr 10.1128/aac.01122-08
Enterobacter cloacae Enterobacter cloacae PAE 7.2 hr 10.1128/aac.01122-08
Enterobacter hormaechei Enterobacter hormaechei MIC 2.0 ug.mL-1 10.1128/aac.01114-07
Enterobacter hormaechei Enterobacter hormaechei MIC 2.0 ug.mL-1 10.1128/aac.01592-08
Enterobacter hormaechei Enterobacter hormaechei MIC 4.0 ug.mL-1 10.1128/aac.01592-08
Enterobacteriaceae Enterobacteriaceae Activity 0.0 % 10.1128/aac.01114-07
Enterobacteriaceae Enterobacteriaceae Activity 2.0 ug ml-1 10.1128/aac.01624-09
Enterobacteriaceae Enterobacteriaceae Activity 4.0 ug ml-1 10.1128/aac.01624-09
Enterobacteriaceae Enterobacteriaceae Activity 8.0 ug ml-1 10.1128/aac.01624-09
Enterobacteriaceae Enterobacteriaceae Activity 100.0 % 10.1128/aac.01114-07
Enterobacteriaceae Enterobacteriaceae MIC 6e-05 ug.mL-1 10.1128/aac.00182-09
Enterobacteriaceae Enterobacteriaceae MIC50 0.00025 ug.mL-1 10.1128/aac.00182-09
Enterobacteriaceae Enterobacteriaceae MIC50 0.5 ug.mL-1 10.1128/aac.01114-07
Enterobacteriaceae Enterobacteriaceae MIC90 0.001 ug.mL-1 10.1128/aac.00182-09
Enterobacteriaceae Enterobacteriaceae MIC90 1.0 ug.mL-1 10.1128/aac.01114-07
Enterobacter sp. Enterobacter sp. Activity 0.0 % 10.1128/aac.01114-07
Enterobacter sp. Enterobacter sp. Activity 100.0 % 10.1128/aac.01114-07
Enterobacter sp. Enterobacter sp. MIC50 0.25 ug.mL-1 10.1128/aac.01114-07
Enterobacter sp. Enterobacter sp. MIC50 0.5 ug.mL-1 10.1128/aac.00572-10
Enterobacter sp. Enterobacter sp. MIC90 0.5 ug.mL-1 10.1128/aac.01114-07
Enterobacter sp. Enterobacter sp. MIC90 4.0 ug.mL-1 10.1128/aac.00572-10
Enterococcus Enterococcus MIC 0.06 ug.mL-1 10.1016/j.bmc.2020.115776
Enterococcus Enterococcus MIC 0.12 ug mg-1 10.1016/s0960-894x(99)00216-4
Enterococcus Enterococcus MIC50 0.25 ug.mL-1 10.1016/j.bmc.2020.115776
Enterococcus Enterococcus MIC90 0.5 ug.mL-1 10.1016/j.bmc.2020.115776
Enterococcus faecalis Enterococcus faecalis MIC 0.0313 ug.mL-1 10.1021/jm1015395
Enterococcus faecalis Enterococcus faecalis MIC 0.06 ug.mL-1 10.1128/aac.01122-08
Enterococcus faecalis Enterococcus faecalis MIC 0.06 ug.mL-1 10.1128/aac.01197-09
Enterococcus faecalis Enterococcus faecalis MIC 0.0625 ug.mL-1 10.1021/jm1015395
Enterococcus faecalis Enterococcus faecalis MIC 0.0625 ug.mL-1 10.1021/jm201465w
Enterococcus faecalis Enterococcus faecalis MIC 0.12 ug.mL-1 10.1016/j.bmc.2020.115776
Enterococcus faecalis Enterococcus faecalis MIC 0.12 ug.mL-1 10.1016/j.bmcl.2005.09.078
Enterococcus faecalis Enterococcus faecalis MIC 0.12 ug.mL-1 10.1128/aac.01084-06
Enterococcus faecalis Enterococcus faecalis MIC 0.125 ug.mL-1 10.1021/acs.jmedchem.5b00262
Enterococcus faecalis Enterococcus faecalis MIC 0.125 ug.mL-1 10.1021/acs.jmedchem.6b01903
Enterococcus faecalis Enterococcus faecalis MIC 0.25 ug.mL-1 10.1016/j.bmc.2020.115776
Enterococcus faecalis Enterococcus faecalis MIC50 0.25 ug.mL-1 10.1128/aac.01197-09
Enterococcus faecalis Enterococcus faecalis MIC90 0.25 ug.mL-1 10.1128/aac.01197-09
Enterococcus faecalis Enterococcus faecalis PAE 0.0 hr 10.1128/aac.01122-08
Enterococcus faecalis Enterococcus faecalis PAE 0.2 hr 10.1128/aac.01122-08
Enterococcus faecalis Enterococcus faecalis PAE 0.3 hr 10.1128/aac.01122-08
Enterococcus faecalis Enterococcus faecalis PAE 0.4 hr 10.1128/aac.01122-08
Enterococcus faecalis Enterococcus faecalis PAE 1.0 hr 10.1128/aac.01122-08
Enterococcus faecalis Enterococcus faecalis PAE 1.8 hr 10.1128/aac.01122-08
Enterococcus faecalis Enterococcus faecalis PAE 3.9 hr 10.1128/aac.01122-08
Enterococcus faecalis Enterococcus faecalis PAE 5.3 hr 10.1128/aac.01122-08
Enterococcus faecalis Enterococcus faecalis PAE 6.0 hr 10.1128/aac.01122-08
Enterococcus faecalis Enterococcus faecalis PAE 6.8 hr 10.1128/aac.01122-08
Enterococcus faecalis Enterococcus faecalis PAE 7.6 hr 10.1128/aac.01122-08
Enterococcus faecalis Enterococcus faecalis PAE 8.2 hr 10.1128/aac.01122-08
Enterococcus faecalis Enterococcus faecalis PAE 10.5 hr 10.1128/aac.01122-08
Enterococcus faecalis Enterococcus faecalis PAE 11.0 hr 10.1128/aac.01122-08
Enterococcus faecium Enterococcus faecium MIC 0.03 ug.mL-1 10.1128/aac.01197-09
Enterococcus faecium Enterococcus faecium MIC 0.0312 ug.mL-1 10.1021/acs.jmedchem.5b00262
Enterococcus faecium Enterococcus faecium MIC 0.0312 ug.mL-1 10.1021/acs.jmedchem.6b01903
Enterococcus faecium Enterococcus faecium MIC 0.06 ug.mL-1 10.1016/j.bmc.2020.115776
Enterococcus faecium Enterococcus faecium MIC 0.06 ug.mL-1 10.1128/aac.01084-06
Enterococcus faecium Enterococcus faecium MIC 0.12 ug.mL-1 10.1016/j.bmc.2020.115776
Enterococcus faecium Enterococcus faecium MIC50 0.06 ug.mL-1 10.1128/aac.01197-09
Enterococcus faecium Enterococcus faecium MIC90 0.12 ug.mL-1 10.1128/aac.01197-09
Enterococcus faecium Enterococcus faecium PAE 2.5 hr 10.1128/aac.01122-08
Enterococcus sp. Enterococcus sp. Activity 0.0 % 10.1128/aac.01538-07
Escherichia coli Escherichia coli Activity 0.0 % 10.1128/aac.01538-07
Escherichia coli Escherichia coli Activity 100.0 % 10.1128/aac.01176-07
Escherichia coli Escherichia coli Activity nan None 10.1128/aac.00625-07
Escherichia coli Escherichia coli IC50 0.47 ug.mL-1 10.1021/jm1015389
Escherichia coli Escherichia coli Inhibition nan % 10.1128/aac.01452-08
Escherichia coli Escherichia coli log10CFU/ml 2.0 None 10.1128/aac.01678-08
Escherichia coli Escherichia coli log10CFU/ml 2.05 None 10.1128/aac.01678-08
Escherichia coli Escherichia coli log10CFU/ml 2.3 None 10.1128/aac.01678-08
Escherichia coli Escherichia coli log10CFU/ml 2.4 None 10.1128/aac.01678-08
Escherichia coli Escherichia coli log10CFU/ml 2.54 None 10.1128/aac.01678-08
Escherichia coli Escherichia coli MBC 0.06 ug ml-1 10.1128/aac.01452-08
Escherichia coli Escherichia coli MBC 0.5 ug ml-1 10.1128/aac.01452-08
Escherichia coli Escherichia coli MBC 1.0 ug ml-1 10.1128/aac.01452-08
Escherichia coli Escherichia coli MIC 0.016 ug.mL-1 10.1128/aac.00299-07
Escherichia coli Escherichia coli MIC 0.0313 ug.mL-1 10.1021/jm1015395
Escherichia coli Escherichia coli MIC 0.06 ug.mL-1 10.1128/aac.00736-08
Escherichia coli Escherichia coli MIC 0.06 ug.mL-1 10.1128/aac.01099-09
Escherichia coli Escherichia coli MIC 0.06 ug.mL-1 10.1128/aac.01452-08
Escherichia coli Escherichia coli MIC 0.064 ug.mL-1 10.1128/aac.01099-09
Escherichia coli Escherichia coli MIC 0.065 ug.mL-1 10.1128/aac.00993-09
Escherichia coli Escherichia coli MIC 0.094 ug.mL-1 10.1128/aac.01818-09
Escherichia coli Escherichia coli MIC 0.12 ug mg-1 10.1016/s0960-894x(99)00216-4
Escherichia coli Escherichia coli MIC 0.12 ug.mL-1 10.1016/j.bmcl.2005.09.078
Escherichia coli Escherichia coli MIC 0.12 ug.mL-1 10.1128/aac.00484-10
Escherichia coli Escherichia coli MIC 0.12 ug.mL-1 10.1128/aac.00883-08
Escherichia coli Escherichia coli MIC 0.12 ug.mL-1 10.1128/aac.01114-07
Escherichia coli Escherichia coli MIC 0.12 ug.mL-1 10.1128/aac.01122-08
Escherichia coli Escherichia coli MIC 0.12 ug.mL-1 10.1128/aac.01176-07
Escherichia coli Escherichia coli MIC 0.12 ug.mL-1 10.1128/aac.01197-09
Escherichia coli Escherichia coli MIC 0.125 ug.mL-1 10.1021/acs.jmedchem.5b00262
Escherichia coli Escherichia coli MIC 0.125 ug.mL-1 10.1021/acs.jmedchem.6b01903
Escherichia coli Escherichia coli MIC 0.125 ug.mL-1 10.1021/jm1015389
Escherichia coli Escherichia coli MIC 0.125 ug.mL-1 10.1021/jm201465w
Escherichia coli Escherichia coli MIC 0.125 ug.mL-1 10.1021/jm201467r
Escherichia coli Escherichia coli MIC 0.125 ug.mL-1 10.1128/aac.00137-10
Escherichia coli Escherichia coli MIC 0.125 ug.mL-1 10.1128/aac.01099-09
Escherichia coli Escherichia coli MIC 0.125 ug.mL-1 10.1128/aac.01359-09
Escherichia coli Escherichia coli MIC 0.125 ug.mL-1 10.1128/aac.01452-08
Escherichia coli Escherichia coli MIC 0.125 ug.mL-1 10.1128/aac.01678-08
Escherichia coli Escherichia coli MIC 0.19 ug.mL-1 10.1128/aac.01359-09
Escherichia coli Escherichia coli MIC 0.25 ug mg-1 10.1016/s0960-894x(99)00216-4
Escherichia coli Escherichia coli MIC 0.25 ug.mL-1 10.1016/j.bmc.2020.115776
Escherichia coli Escherichia coli MIC 0.25 ug.mL-1 10.1016/j.bmcl.2005.09.078
Escherichia coli Escherichia coli MIC 0.25 ug.mL-1 10.1016/j.ejmech.2018.03.031
Escherichia coli Escherichia coli MIC 0.25 ug.mL-1 10.1021/acs.jmedchem.9b00720
Escherichia coli Escherichia coli MIC 0.25 ug.mL-1 10.1128/aac.00688-09
Escherichia coli Escherichia coli MIC 0.25 ug.mL-1 10.1128/aac.00883-08
Escherichia coli Escherichia coli MIC 0.25 ug.mL-1 10.1128/aac.00899-09
Escherichia coli Escherichia coli MIC 0.25 ug.mL-1 10.1128/aac.00993-09
Escherichia coli Escherichia coli MIC 0.25 ug.mL-1 10.1128/aac.01084-06
Escherichia coli Escherichia coli MIC 0.25 ug.mL-1 10.1128/aac.01099-09
Escherichia coli Escherichia coli MIC 0.25 ug.mL-1 10.1128/aac.01176-07
Escherichia coli Escherichia coli MIC 0.25 ug.mL-1 10.1128/aac.01678-08
Escherichia coli Escherichia coli MIC 0.38 ug.mL-1 10.1128/aac.00436-09
Escherichia coli Escherichia coli MIC 0.38 ug.mL-1 10.1128/aac.01359-09
Escherichia coli Escherichia coli MIC 0.5 ug mg-1 10.1016/s0960-894x(99)00216-4
Escherichia coli Escherichia coli MIC 0.5 ug.mL-1 10.1016/j.bmcl.2005.09.078
Escherichia coli Escherichia coli MIC 0.5 ug.mL-1 10.1016/j.ejmech.2018.03.031
Escherichia coli Escherichia coli MIC 0.5 ug.mL-1 10.1016/j.ejmech.2019.02.024
Escherichia coli Escherichia coli MIC 0.5 ug.mL-1 10.1021/acs.jmedchem.9b00720
Escherichia coli Escherichia coli MIC 0.5 ug.mL-1 10.1021/jm1015389
Escherichia coli Escherichia coli MIC 0.5 ug.mL-1 10.1021/jm1015395
Escherichia coli Escherichia coli MIC 0.5 ug.mL-1 10.1021/jm201467r
Escherichia coli Escherichia coli MIC 0.5 ug.mL-1 10.1128/aac.00158-08
Escherichia coli Escherichia coli MIC 0.5 ug.mL-1 10.1128/aac.00543-08
Escherichia coli Escherichia coli MIC 0.5 ug.mL-1 10.1128/aac.01180-07
Escherichia coli Escherichia coli MIC 0.5 ug.mL-1 10.1128/aac.01452-08
Escherichia coli Escherichia coli MIC 0.5 ug.mL-1 10.1128/aac.01678-08
Escherichia coli Escherichia coli MIC 0.75 ug.mL-1 10.1128/aac.01359-09
Escherichia coli Escherichia coli MIC 1.0 ug.mL-1 10.1021/acs.jmedchem.5b00262
Escherichia coli Escherichia coli MIC 1.0 ug.mL-1 10.1021/acs.jmedchem.6b01903
Escherichia coli Escherichia coli MIC 1.0 ug.mL-1 10.1021/jm201465w
Escherichia coli Escherichia coli MIC 1.0 ug.mL-1 10.1128/aac.01099-09
Escherichia coli Escherichia coli MIC 16.0 ug.mL-1 10.1016/j.ejmech.2019.02.024
Escherichia coli Escherichia coli MIC50 0.12 ug.mL-1 10.1128/aac.00484-10
Escherichia coli Escherichia coli MIC50 0.25 ug.mL-1 10.1021/jm1015389
Escherichia coli Escherichia coli MIC50 0.25 ug.mL-1 10.1128/aac.00572-10
Escherichia coli Escherichia coli MIC50 0.25 ug.mL-1 10.1128/aac.00625-07
Escherichia coli Escherichia coli MIC50 0.25 ug.mL-1 10.1128/aac.00883-08
Escherichia coli Escherichia coli MIC50 0.25 ug.mL-1 10.1128/aac.01176-07
Escherichia coli Escherichia coli MIC50 0.25 ug.mL-1 10.1128/aac.01197-09
Escherichia coli Escherichia coli MIC50 0.5 ug.mL-1 10.1128/aac.00625-07
Escherichia coli Escherichia coli MIC50 0.5 ug.mL-1 10.1128/aac.00883-08
Escherichia coli Escherichia coli MIC50 0.5 ug.mL-1 10.1128/aac.01176-07
Escherichia coli Escherichia coli MIC90 0.25 ug.mL-1 10.1128/aac.00484-10
Escherichia coli Escherichia coli MIC90 0.25 ug.mL-1 10.1128/aac.00625-07
Escherichia coli Escherichia coli MIC90 0.5 ug.mL-1 10.1021/jm1015389
Escherichia coli Escherichia coli MIC90 0.5 ug.mL-1 10.1128/aac.00572-10
Escherichia coli Escherichia coli MIC90 0.5 ug.mL-1 10.1128/aac.00625-07
Escherichia coli Escherichia coli MIC90 0.5 ug.mL-1 10.1128/aac.00883-08
Escherichia coli Escherichia coli MIC90 0.5 ug.mL-1 10.1128/aac.01176-07
Escherichia coli Escherichia coli MIC90 0.5 ug.mL-1 10.1128/aac.01197-09
Escherichia coli Escherichia coli MIC90 1.0 ug.mL-1 10.1021/acs.jmedchem.9b01605
Escherichia coli Escherichia coli MIC90 1.0 ug.mL-1 10.1128/aac.00625-07
Escherichia coli Escherichia coli MIC90 1.0 ug.mL-1 10.1128/aac.01176-07
Escherichia coli Escherichia coli MIC90 8.0 ug.mL-1 10.1128/aac.01197-09
Escherichia coli Escherichia coli PAE 0.0 hr 10.1128/aac.01122-08
Escherichia coli Escherichia coli PAE 0.1 hr 10.1128/aac.01122-08
Escherichia coli Escherichia coli PAE 1.9 hr 10.1128/aac.01122-08
Escherichia coli Escherichia coli PAE 2.0 hr 10.1128/aac.01122-08
Escherichia coli Escherichia coli PAE 2.2 hr 10.1128/aac.01122-08
Escherichia coli Escherichia coli PAE 2.4 hr 10.1128/aac.01122-08
Escherichia coli Escherichia coli PAE 2.9 hr 10.1128/aac.01122-08
Escherichia coli Escherichia coli PAE 3.3 hr 10.1128/aac.01122-08
Escherichia coli Escherichia coli PAE 3.5 hr 10.1128/aac.01122-08
Escherichia coli Escherichia coli PAE 4.9 hr 10.1128/aac.01122-08
Escherichia coli Escherichia coli PD50 2.1 mg kg-1 10.1021/jm1015389
Escherichia coli Escherichia coli PD50 3.5 mg kg-1 10.1021/jm201465w
Haemophilus influenzae Haemophilus influenzae Activity nan None 10.1128/aac.01538-07
Haemophilus influenzae Haemophilus influenzae ED50 2.31 mg.kg-1 10.1016/j.bmc.2016.07.029
Haemophilus influenzae Haemophilus influenzae MIC 0.06 ug.mL-1 10.1128/aac.01122-08
Haemophilus influenzae Haemophilus influenzae MIC 0.12 ug.mL-1 10.1128/aac.01122-08
Haemophilus influenzae Haemophilus influenzae MIC 0.12 ug.mL-1 10.1128/aac.01197-09
Haemophilus influenzae Haemophilus influenzae MIC 0.25 ug.mL-1 10.1016/j.bmc.2016.07.029
Haemophilus influenzae Haemophilus influenzae MIC 0.25 ug.mL-1 10.1021/jm1015389
Haemophilus influenzae Haemophilus influenzae MIC nan None 10.1016/j.bmc.2020.115776
Haemophilus influenzae Haemophilus influenzae MIC50 0.5 ug.mL-1 10.1021/jm1015389
Haemophilus influenzae Haemophilus influenzae MIC50 0.5 ug.mL-1 10.1128/aac.01197-09
Haemophilus influenzae Haemophilus influenzae MIC90 0.25 ug.mL-1 10.1021/acs.jmedchem.9b01605
Haemophilus influenzae Haemophilus influenzae MIC90 0.5 ug.mL-1 10.1021/jm1015389
Haemophilus influenzae Haemophilus influenzae MIC90 1.0 ug.mL-1 10.1128/aac.01197-09
Haemophilus influenzae Haemophilus influenzae PAE 0.0 hr 10.1128/aac.01122-08
Haemophilus influenzae Haemophilus influenzae PAE 0.8 hr 10.1128/aac.01122-08
Haemophilus influenzae Haemophilus influenzae PAE 1.1 hr 10.1128/aac.01122-08
Haemophilus influenzae Haemophilus influenzae PAE 1.9 hr 10.1128/aac.01122-08
Haemophilus influenzae Haemophilus influenzae PAE 2.8 hr 10.1128/aac.01122-08
Haemophilus influenzae Haemophilus influenzae PAE 3.7 hr 10.1128/aac.01122-08
Haemophilus influenzae Haemophilus influenzae PAE 3.9 hr 10.1128/aac.01122-08
Haemophilus influenzae Haemophilus influenzae PAE 4.7 hr 10.1128/aac.01122-08
Haemophilus influenzae Haemophilus influenzae PAE 5.4 hr 10.1128/aac.01122-08
Haemophilus influenzae Haemophilus influenzae PAE 7.7 hr 10.1128/aac.01122-08
Haemophilus influenzae Haemophilus influenzae PAE 7.9 hr 10.1128/aac.01122-08
Homo sapiens Adenosine A1 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Adenosine A2a receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Adenosine A3 receptor AC50 26920.3 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-1a adrenergic receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-2a adrenergic receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-2b adrenergic receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-2c adrenergic receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Beta-1 adrenergic receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Beta-2 adrenergic receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Bile salt export pump IC50 133000.0 nM 10.1093/toxsci/kft176
Homo sapiens Bradykinin B2 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Canalicular multispecific organic anion transporter 1 IC50 133000.0 nM 10.1093/toxsci/kft176
Homo sapiens Canalicular multispecific organic anion transporter 2 IC50 133000.0 nM 10.1093/toxsci/kft176
Homo sapiens Cannabinoid CB1 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Cholecystokinin A receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Cholecystokinin B receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Cyclooxygenase-2 AC50 189.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Delta opioid receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine D1 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine D2 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine D3 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine transporter AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Equilibrative nucleoside transporter 1 AC50 39510.3 nM 10.1038/s41467-023-40064-9
Homo sapiens Estrogen receptor alpha AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Ghrelin receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Glucocorticoid receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens HERG AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Histamine H1 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Histamine H2 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Histamine H3 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Homo sapiens AUC 2660.0 ng.hr.mL-1 10.1128/aac.01084-06
Homo sapiens Homo sapiens AUC 4700.0 ng.hr.mL-1 10.1128/aac.00979-08
Homo sapiens Homo sapiens AUC 5390.0 ng.hr.mL-1 10.1128/aac.01084-06
Homo sapiens Homo sapiens AUC 6190.0 ng.hr.mL-1 10.1128/aac.00182-09
Homo sapiens Homo sapiens CL 3.8 mL.min-1.kg-1 10.1021/jm900403j
Homo sapiens Homo sapiens CL 14.6 L/hr 10.1128/aac.00065-07
Homo sapiens Homo sapiens CL 16.1 L/hr 10.1128/aac.00182-09
Homo sapiens Homo sapiens CL 19.2 L/hr 10.1128/aac.01414-09
Homo sapiens Homo sapiens CLd 85.1 L/hr 10.1128/aac.01414-09
Homo sapiens Homo sapiens CL_renal 0.57 mL.min-1.kg-1 10.1021/jm900403j
Homo sapiens Homo sapiens Cmax 1075.71 nM 10.1128/aac.00979-08
Homo sapiens Homo sapiens DILI_Concern nan None 10.1016/j.drudis.2016.02.015
Homo sapiens Homo sapiens DILI_severity_class 8.0 None 10.1016/j.drudis.2016.02.015
Homo sapiens Homo sapiens Vc 65.2 l 10.1128/aac.01414-09
Homo sapiens Homo sapiens Vd 30.9 l 10.1128/aac.00065-07
Homo sapiens Homo sapiens Vdss 398.0 l 10.1128/aac.01414-09
Homo sapiens Kappa opioid receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Melanocortin receptor 3 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Melanocortin receptor 4 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens microRNA 21 Inhibition 40.0 % 10.1021/acsmedchemlett.9b00091
Homo sapiens Monoamine oxidase A AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Motilin receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Multidrug resistance-associated protein 4 IC50 133000.0 nM 10.1093/toxsci/kft176
Homo sapiens Mu opioid receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Muscarinic acetylcholine receptor M1 AC50 26999.8 nM 10.1038/s41467-023-40064-9
Homo sapiens Muscarinic acetylcholine receptor M2 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Muscarinic acetylcholine receptor M3 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Neuronal acetylcholine receptor protein alpha-4 subunit AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Neuropeptide Y receptor type 1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Norepinephrine transporter AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Phosphodiesterase 3A AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Phosphodiesterase 4D AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Plasma AUC 2650.0 ng.hr.mL-1 10.1128/aac.01051-10
Homo sapiens Plasma AUC 3990.0 ng.hr.mL-1 10.1128/aac.01051-10
Homo sapiens Plasma CL 4.667 mL.min-1.kg-1 10.1128/aac.01051-10
Homo sapiens Plasma Cmax 717.14 nM 10.1128/aac.01051-10
Homo sapiens Plasma Cmax 1707.48 nM 10.1128/aac.01145-08
Homo sapiens Plasma Cmax_unbound 0.16 ug ml-1 10.1128/aac.01051-10
Homo sapiens Plasma Fu 0.2 None 10.1128/aac.01145-08
Homo sapiens Plasma PPB 35.6 % 10.1128/aac.01051-10
Homo sapiens Plasma PPB 71.0 % 10.1128/aac.00647-08
Homo sapiens Plasma PPB 80.3 % 10.1128/aac.01051-10
Homo sapiens Plasma PPB 100.0 % 10.1128/aac.01051-10
Homo sapiens Plasma T1/2 9.73 hr 10.1128/aac.01051-10
Homo sapiens Plasma Tmax 1.13 hr 10.1128/aac.01051-10
Homo sapiens Plasma Vdss 3.95 L.kg-1 10.1128/aac.01051-10
Homo sapiens Pregnane X receptor AC50 2390.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Progesterone receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 1a (5-HT1a) receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2a (5-HT2a) receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2b (5-HT2b) receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2c (5-HT2c) receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 3a (5-HT3a) receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin transporter AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serum AUC 4840.0 ng.hr.mL-1 10.1128/aac.00065-07
Homo sapiens Serum AUC 5090.0 ng.hr.mL-1 10.1128/aac.00065-07
Homo sapiens Serum AUC 6160.0 ng.hr.mL-1 10.1128/aac.00065-07
Homo sapiens Serum AUC 8720.0 ng.hr.mL-1 10.1128/aac.00065-07
Homo sapiens Serum AUC 18500.0 ng.hr.mL-1 10.1128/aac.00065-07
Homo sapiens Serum Cmax 1075.71 nM 10.1128/aac.01097-08
Homo sapiens Serum Css 0.63 mg/L 10.1128/aac.00414-10
Homo sapiens Serum Drug uptake 0.6 ug ml-1 10.1128/aac.01122-08
Homo sapiens Serum PPB 71.0 % 10.1128/aac.00065-07
Homo sapiens Serum T1/2 40.0 hr 10.1128/aac.01122-08
Homo sapiens Thromboxane A2 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Type-1 angiotensin II receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Vasopressin V1a receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Vasopressin V2 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Klebsiella aerogenes Klebsiella aerogenes MIC 0.064 ug.mL-1 10.1128/aac.01099-09
Klebsiella aerogenes Klebsiella aerogenes MIC 1.0 ug.mL-1 10.1016/j.ejmech.2018.03.031
Klebsiella aerogenes Klebsiella aerogenes MIC 1.0 ug.mL-1 10.1128/aac.01099-09
Klebsiella aerogenes Klebsiella aerogenes MIC90 1.0 ug.mL-1 10.1021/acs.jmedchem.9b01605
Klebsiella oxytoca Klebsiella oxytoca MIC 0.12 ug.mL-1 10.1128/aac.01114-07
Klebsiella oxytoca Klebsiella oxytoca MIC 0.25 ug.mL-1 10.1128/aac.01114-07
Klebsiella oxytoca Klebsiella oxytoca MIC 0.25 ug.mL-1 10.1128/aac.01355-08
Klebsiella oxytoca Klebsiella oxytoca MIC 0.5 ug.mL-1 10.1128/aac.01084-06
Klebsiella oxytoca Klebsiella oxytoca MIC 0.5 ug.mL-1 10.1128/aac.01114-07
Klebsiella oxytoca Klebsiella oxytoca MIC 2.0 ug.mL-1 10.1128/aac.00260-09
Klebsiella oxytoca Klebsiella oxytoca MIC90 0.5 ug.mL-1 10.1021/acs.jmedchem.9b01605
Klebsiella pneumoniae Klebsiella pneumoniae Activity 90.2 % 10.1128/aac.00556-09
Klebsiella pneumoniae Klebsiella pneumoniae Activity 96.0 % 10.1128/aac.00556-09
Klebsiella pneumoniae Klebsiella pneumoniae Activity nan None 10.1128/aac.00893-06
Klebsiella pneumoniae Klebsiella pneumoniae Activity nan None 10.1128/aac.01538-07
Klebsiella pneumoniae Klebsiella pneumoniae Inhibition nan % 10.1128/aac.01452-08
Klebsiella pneumoniae Klebsiella pneumoniae log10CFU/ml 1.12 None 10.1128/aac.01678-08
Klebsiella pneumoniae Klebsiella pneumoniae log10CFU/ml 1.34 None 10.1128/aac.01678-08
Klebsiella pneumoniae Klebsiella pneumoniae log10CFU/ml 1.42 None 10.1128/aac.01678-08
Klebsiella pneumoniae Klebsiella pneumoniae log10CFU/ml 1.46 None 10.1128/aac.01678-08
Klebsiella pneumoniae Klebsiella pneumoniae log10CFU/ml 1.51 None 10.1128/aac.01678-08
Klebsiella pneumoniae Klebsiella pneumoniae log10CFU/ml 3.15 None 10.1128/aac.01678-08
Klebsiella pneumoniae Klebsiella pneumoniae MBC 0.5 ug ml-1 10.1128/aac.01452-08
Klebsiella pneumoniae Klebsiella pneumoniae MBC 1.0 ug ml-1 10.1128/aac.01452-08
Klebsiella pneumoniae Klebsiella pneumoniae MBC 2.0 ug ml-1 10.1128/aac.01452-08
Klebsiella pneumoniae Klebsiella pneumoniae MIC 0.015 ug.mL-1 10.1128/aac.00484-10
Klebsiella pneumoniae Klebsiella pneumoniae MIC 0.06 ug.mL-1 10.1128/aac.01099-09
Klebsiella pneumoniae Klebsiella pneumoniae MIC 0.064 ug.mL-1 10.1128/aac.01099-09
Klebsiella pneumoniae Klebsiella pneumoniae MIC 0.12 ug.mL-1 10.1128/aac.01114-07
Klebsiella pneumoniae Klebsiella pneumoniae MIC 0.125 ug.mL-1 10.1021/jm1015389
Klebsiella pneumoniae Klebsiella pneumoniae MIC 0.125 ug.mL-1 10.1021/jm1015395
Klebsiella pneumoniae Klebsiella pneumoniae MIC 0.125 ug.mL-1 10.1021/jm201467r
Klebsiella pneumoniae Klebsiella pneumoniae MIC 0.125 ug.mL-1 10.1128/aac.01099-09
Klebsiella pneumoniae Klebsiella pneumoniae MIC 0.125 ug.mL-1 10.1128/aac.01452-08
Klebsiella pneumoniae Klebsiella pneumoniae MIC 0.125 ug.mL-1 10.1128/aac.01818-09
Klebsiella pneumoniae Klebsiella pneumoniae MIC 0.13 ug.mL-1 10.1128/aac.01099-09
Klebsiella pneumoniae Klebsiella pneumoniae MIC 0.19 ug.mL-1 10.1128/aac.01818-09
Klebsiella pneumoniae Klebsiella pneumoniae MIC 0.25 ug.mL-1 10.1021/jm201465w
Klebsiella pneumoniae Klebsiella pneumoniae MIC 0.25 ug.mL-1 10.1128/aac.00883-08
Klebsiella pneumoniae Klebsiella pneumoniae MIC 0.25 ug.mL-1 10.1128/aac.01099-09
Klebsiella pneumoniae Klebsiella pneumoniae MIC 0.25 ug.mL-1 10.1128/aac.01114-07
Klebsiella pneumoniae Klebsiella pneumoniae MIC 0.25 ug.mL-1 10.1128/aac.01122-08
Klebsiella pneumoniae Klebsiella pneumoniae MIC 0.25 ug.mL-1 10.1128/aac.01197-09
Klebsiella pneumoniae Klebsiella pneumoniae MIC 0.25 ug.mL-1 10.1128/aac.01355-08
Klebsiella pneumoniae Klebsiella pneumoniae MIC 0.38 ug.mL-1 10.1128/aac.00137-10
Klebsiella pneumoniae Klebsiella pneumoniae MIC 0.38 ug.mL-1 10.1128/aac.00260-09
Klebsiella pneumoniae Klebsiella pneumoniae MIC 0.38 ug.mL-1 10.1128/aac.00736-08
Klebsiella pneumoniae Klebsiella pneumoniae MIC 0.5 ug.mL-1 10.1016/j.ejmech.2018.03.031
Klebsiella pneumoniae Klebsiella pneumoniae MIC 0.5 ug.mL-1 10.1016/j.ejmech.2019.02.024
Klebsiella pneumoniae Klebsiella pneumoniae MIC 0.5 ug.mL-1 10.1128/aac.00260-09
Klebsiella pneumoniae Klebsiella pneumoniae MIC 0.5 ug.mL-1 10.1128/aac.00299-07
Klebsiella pneumoniae Klebsiella pneumoniae MIC 0.5 ug.mL-1 10.1128/aac.00484-10
Klebsiella pneumoniae Klebsiella pneumoniae MIC 0.5 ug.mL-1 10.1128/aac.00736-08
Klebsiella pneumoniae Klebsiella pneumoniae MIC 0.5 ug.mL-1 10.1128/aac.00883-08
Klebsiella pneumoniae Klebsiella pneumoniae MIC 0.5 ug.mL-1 10.1128/aac.01084-06
Klebsiella pneumoniae Klebsiella pneumoniae MIC 0.5 ug.mL-1 10.1128/aac.01099-09
Klebsiella pneumoniae Klebsiella pneumoniae MIC 0.5 ug.mL-1 10.1128/aac.01247-10
Klebsiella pneumoniae Klebsiella pneumoniae MIC 0.5 ug.mL-1 10.1128/aac.01355-08
Klebsiella pneumoniae Klebsiella pneumoniae MIC 0.5 ug.mL-1 10.1128/aac.01452-08
Klebsiella pneumoniae Klebsiella pneumoniae MIC 0.5 ug.mL-1 10.1128/aac.01678-08
Klebsiella pneumoniae Klebsiella pneumoniae MIC 0.5 ug.mL-1 10.1128/aac.01818-09
Klebsiella pneumoniae Klebsiella pneumoniae MIC 0.75 ug.mL-1 10.1128/aac.01818-09
Klebsiella pneumoniae Klebsiella pneumoniae MIC 1.0 ug.mL-1 10.1016/j.ejmech.2018.03.031
Klebsiella pneumoniae Klebsiella pneumoniae MIC 1.0 ug.mL-1 10.1021/acs.jmedchem.5b00262
Klebsiella pneumoniae Klebsiella pneumoniae MIC 1.0 ug.mL-1 10.1021/acs.jmedchem.6b01903
Klebsiella pneumoniae Klebsiella pneumoniae MIC 1.0 ug.mL-1 10.1021/acs.jmedchem.9b00720
Klebsiella pneumoniae Klebsiella pneumoniae MIC 1.0 ug.mL-1 10.1021/jm1015395
Klebsiella pneumoniae Klebsiella pneumoniae MIC 1.0 ug.mL-1 10.1021/jm201465w
Klebsiella pneumoniae Klebsiella pneumoniae MIC 1.0 ug.mL-1 10.1128/aac.00260-09
Klebsiella pneumoniae Klebsiella pneumoniae MIC 1.0 ug.mL-1 10.1128/aac.01099-09
Klebsiella pneumoniae Klebsiella pneumoniae MIC 1.0 ug.mL-1 10.1128/aac.01114-07
Klebsiella pneumoniae Klebsiella pneumoniae MIC 1.0 ug.mL-1 10.1128/aac.01355-08
Klebsiella pneumoniae Klebsiella pneumoniae MIC 1.0 ug.mL-1 10.1128/aac.01818-09
Klebsiella pneumoniae Klebsiella pneumoniae MIC 1.5 ug.mL-1 10.1128/aac.00158-08
Klebsiella pneumoniae Klebsiella pneumoniae MIC 1.5 ug.mL-1 10.1128/aac.00543-08
Klebsiella pneumoniae Klebsiella pneumoniae MIC 1.5 ug.mL-1 10.1128/aac.01818-09
Klebsiella pneumoniae Klebsiella pneumoniae MIC 2.0 ug.mL-1 10.1016/j.ejmech.2019.02.024
Klebsiella pneumoniae Klebsiella pneumoniae MIC 2.0 ug.mL-1 10.1128/aac.00260-09
Klebsiella pneumoniae Klebsiella pneumoniae MIC 2.0 ug.mL-1 10.1128/aac.00299-07
Klebsiella pneumoniae Klebsiella pneumoniae MIC 2.0 ug.mL-1 10.1128/aac.00543-08
Klebsiella pneumoniae Klebsiella pneumoniae MIC 2.0 ug.mL-1 10.1128/aac.01099-09
Klebsiella pneumoniae Klebsiella pneumoniae MIC 2.0 ug.mL-1 10.1128/aac.01355-08
Klebsiella pneumoniae Klebsiella pneumoniae MIC 2.0 ug.mL-1 10.1128/aac.01678-08
Klebsiella pneumoniae Klebsiella pneumoniae MIC 2.0 ug.mL-1 10.1128/aac.01818-09
Klebsiella pneumoniae Klebsiella pneumoniae MIC 3.0 ug.mL-1 10.1128/aac.00436-09
Klebsiella pneumoniae Klebsiella pneumoniae MIC 3.0 ug.mL-1 10.1128/aac.01180-07
Klebsiella pneumoniae Klebsiella pneumoniae MIC 4.0 ug.mL-1 10.1021/acs.jmedchem.9b00720
Klebsiella pneumoniae Klebsiella pneumoniae MIC 4.0 ug.mL-1 10.1128/aac.00011-10
Klebsiella pneumoniae Klebsiella pneumoniae MIC 4.0 ug.mL-1 10.1128/aac.01099-09
Klebsiella pneumoniae Klebsiella pneumoniae MIC 4.0 ug.mL-1 10.1128/aac.01355-08
Klebsiella pneumoniae Klebsiella pneumoniae MIC 4.0 ug.mL-1 10.1128/aac.01818-09
Klebsiella pneumoniae Klebsiella pneumoniae MIC 8.0 ug.mL-1 10.1016/j.ejmech.2018.03.031
Klebsiella pneumoniae Klebsiella pneumoniae MIC 16.0 ug.mL-1 10.1128/aac.01099-09
Klebsiella pneumoniae Klebsiella pneumoniae MIC50 0.03 ug.mL-1 10.1128/aac.00484-10
Klebsiella pneumoniae Klebsiella pneumoniae MIC50 0.5 ug.mL-1 10.1128/aac.00883-08
Klebsiella pneumoniae Klebsiella pneumoniae MIC50 0.5 ug.mL-1 10.1128/aac.01197-09
Klebsiella pneumoniae Klebsiella pneumoniae MIC50 1.0 ug.mL-1 10.1128/aac.00484-10
Klebsiella pneumoniae Klebsiella pneumoniae MIC50 1.0 ug.mL-1 10.1128/aac.00556-09
Klebsiella pneumoniae Klebsiella pneumoniae MIC50 1.0 ug.mL-1 10.1128/aac.00883-08
Klebsiella pneumoniae Klebsiella pneumoniae MIC90 1.0 ug.mL-1 10.1128/aac.00883-08
Klebsiella pneumoniae Klebsiella pneumoniae MIC90 1.0 ug.mL-1 10.1128/aac.01197-09
Klebsiella pneumoniae Klebsiella pneumoniae MIC90 2.0 ug.mL-1 10.1128/aac.00484-10
Klebsiella pneumoniae Klebsiella pneumoniae MIC90 2.0 ug.mL-1 10.1128/aac.00556-09
Klebsiella pneumoniae Klebsiella pneumoniae MIC90 2.0 ug.mL-1 10.1128/aac.00883-08
Klebsiella pneumoniae Klebsiella pneumoniae MIC90 4.0 ug.mL-1 10.1021/acs.jmedchem.9b01605
Klebsiella pneumoniae Klebsiella pneumoniae MIC90 8.0 ug.mL-1 10.1128/aac.00484-10
Klebsiella pneumoniae Klebsiella pneumoniae PAE 0.1 hr 10.1128/aac.01122-08
Klebsiella pneumoniae Klebsiella pneumoniae PAE 0.4 hr 10.1128/aac.01122-08
Klebsiella pneumoniae Klebsiella pneumoniae PAE 0.7 hr 10.1128/aac.01122-08
Klebsiella pneumoniae Klebsiella pneumoniae PAE 1.7 hr 10.1128/aac.01122-08
Klebsiella pneumoniae Klebsiella pneumoniae PAE 1.8 hr 10.1128/aac.01122-08
Klebsiella pneumoniae Klebsiella pneumoniae PAE 1.9 hr 10.1128/aac.01122-08
Klebsiella pneumoniae Klebsiella pneumoniae PAE 2.0 hr 10.1128/aac.01122-08
Klebsiella pneumoniae Klebsiella pneumoniae PAE 2.3 hr 10.1128/aac.01122-08
Klebsiella pneumoniae Klebsiella pneumoniae PAE 2.6 hr 10.1128/aac.01122-08
Klebsiella sp. Klebsiella sp. Activity 0.0 % 10.1128/aac.01114-07
Klebsiella sp. Klebsiella sp. Activity 100.0 % 10.1128/aac.01114-07
Klebsiella sp. Klebsiella sp. MIC50 1.0 ug.mL-1 10.1128/aac.00572-10
Klebsiella sp. Klebsiella sp. MIC50 1.0 ug.mL-1 10.1128/aac.01114-07
Klebsiella sp. Klebsiella sp. MIC90 2.0 ug.mL-1 10.1128/aac.00572-10
Klebsiella sp. Klebsiella sp. MIC90 2.0 ug.mL-1 10.1128/aac.01114-07
Listeria monocytogenes Listeria monocytogenes MIC 0.03 ug.mL-1 10.1128/aac.01129-07
Listeria monocytogenes Listeria monocytogenes MIC50 0.06 ug.mL-1 10.1128/aac.01129-07
Listeria monocytogenes Listeria monocytogenes MIC90 0.125 ug.mL-1 10.1128/aac.01129-07
Moraxella catarrhalis Moraxella catarrhalis MIC90 0.5 ug.mL-1 10.1021/acs.jmedchem.9b01605
Morganella morganii Morganella morganii MIC90 8.0 ug.mL-1 10.1021/acs.jmedchem.9b01605
Mus musculus Mus musculus Activity nan None 10.1128/aac.00979-08
Mus musculus Mus musculus AUC 1200.0 ng.hr.mL-1 10.1128/aac.00647-08
Mus musculus Mus musculus AUC 2900.0 ng.hr.mL-1 10.1128/aac.00979-08
Mus musculus Mus musculus AUC 4800.0 ng.hr.mL-1 10.1128/aac.00647-08
Mus musculus Mus musculus AUC 4800.0 ng.hr.mL-1 10.1128/aac.01678-08
Mus musculus Mus musculus AUC 9100.0 ng.hr.mL-1 10.1128/aac.00647-08
Mus musculus Mus musculus AUC 9980.0 ng.hr.mL-1 10.1128/aac.00985-09
Mus musculus Mus musculus AUC 16520.0 ng.hr.mL-1 10.1128/aac.00985-09
Mus musculus Mus musculus AUC 25200.0 ng.hr.mL-1 10.1128/aac.00647-08
Mus musculus Mus musculus AUC 37490.0 ng.hr.mL-1 10.1128/aac.00985-09
Mus musculus Mus musculus AUC 49190.0 ng.hr.mL-1 10.1128/aac.00647-08
Mus musculus Mus musculus AUC 72520.0 ng.hr.mL-1 10.1128/aac.00985-09
Mus musculus Mus musculus Cmax 3.0 mg Kg-1 10.1128/aac.00979-08
Mus musculus Mus musculus Cmax 2680.74 nM 10.1128/aac.00985-09
Mus musculus Mus musculus Cmax 2868.56 nM 10.1128/aac.00647-08
Mus musculus Mus musculus Cmax 2902.71 nM 10.1128/aac.01678-08
Mus musculus Mus musculus Cmax 4063.79 nM 10.1128/aac.00647-08
Mus musculus Mus musculus Cmax 5276.1 nM 10.1128/aac.00985-09
Mus musculus Mus musculus Cmax 9100.84 nM 10.1128/aac.00647-08
Mus musculus Mus musculus Cmax 10227.78 nM 10.1128/aac.00985-09
Mus musculus Mus musculus Cmax 20899.5 nM 10.1128/aac.00647-08
Mus musculus Mus musculus Cmax 26978.11 nM 10.1128/aac.00985-09
Mus musculus Mus musculus F nan % 10.1021/jm201467r
Mus musculus Mus musculus PPB 85.0 % 10.1128/aac.00985-09
Mus musculus Mus musculus T1/2 7.13 hr 10.1128/aac.00985-09
Mus musculus Mus musculus T1/2 7.36 hr 10.1128/aac.00647-08
Mus musculus Mus musculus T1/2 9.9 hr 10.1128/aac.01678-08
Mus musculus Mus musculus T1/2 10.05 hr 10.1128/aac.00647-08
Mus musculus Mus musculus T1/2 10.53 hr 10.1128/aac.00647-08
Mus musculus Mus musculus T1/2 11.52 hr 10.1128/aac.00985-09
Mus musculus Mus musculus T1/2 11.8 hr 10.1128/aac.00647-08
Mus musculus Mus musculus T1/2 12.4 hr 10.1128/aac.00985-09
Mus musculus Mus musculus T1/2 12.43 hr 10.1128/aac.00985-09
Mus musculus Mus musculus Tmax 0.08 hr 10.1128/aac.00647-08
Mus musculus Mus musculus Tmax 0.27 hr 10.1128/aac.00985-09
Mus musculus Mus musculus Tmax 0.34 hr 10.1128/aac.00985-09
Mus musculus Mus musculus Tmax 0.35 hr 10.1128/aac.00985-09
Mus musculus Mus musculus Tmax 0.45 hr 10.1128/aac.00647-08
Mus musculus Mus musculus Tmax 0.53 hr 10.1128/aac.00647-08
Mus musculus Mus musculus Tmax 0.74 hr 10.1128/aac.00647-08
Mus musculus Mus musculus Tmax 0.74 hr 10.1128/aac.00985-09
Mus musculus Mus musculus Vd 2.62 L.kg-1 10.1128/aac.00985-09
Mus musculus Mus musculus Vd 2.77 L.kg-1 10.1128/aac.00985-09
Mus musculus Mus musculus Vd 3.44 L.kg-1 10.1128/aac.00985-09
Mus musculus Mus musculus Vd 3.62 L.kg-1 10.1128/aac.00985-09
Mus musculus Plasma PPB 81.2 % 10.1128/aac.00647-08
Mus musculus Serum fAUC 200.0 ng.hr.mL-1 10.1128/aac.00647-08
Mus musculus Serum PPB 65.7 % 10.1128/aac.00647-08
Mus musculus Serum PPB 81.2 % 10.1128/aac.00647-08
Mus musculus Serum PPB 82.7 % 10.1128/aac.00647-08
Mus musculus Serum PPB 87.2 % 10.1128/aac.00985-09
Mus musculus Serum PPB 87.9 % 10.1128/aac.00647-08
Mus musculus Serum PPB 92.0 % 10.1128/aac.00647-08
Mus musculus Serum PPB 92.5 % 10.1128/aac.00647-08
Mus musculus Serum PPB 92.9 % 10.1128/aac.00647-08
Mus musculus Serum PPB 93.1 % 10.1128/aac.00647-08
Mus musculus Serum PPB 93.7 % 10.1128/aac.00985-09
Mus musculus Serum PPB 95.9 % 10.1128/aac.00985-09
Mycobacteroides abscessus Mycobacteroides abscessus MIC50 0.06 ug.mL-1 10.1128/aac.00695-08
Mycobacteroides abscessus Mycobacteroides abscessus MIC90 0.5 ug.mL-1 10.1128/aac.00695-08
Mycobacteroides chelonae Mycobacteroides chelonae MIC50 0.12 ug.mL-1 10.1128/aac.00695-08
Mycobacteroides chelonae Mycobacteroides chelonae MIC90 0.5 ug.mL-1 10.1128/aac.00695-08
Mycolicibacterium fortuitum Mycolicibacterium fortuitum MIC50 0.03 ug.mL-1 10.1128/aac.00695-08
Mycolicibacterium fortuitum Mycolicibacterium fortuitum MIC90 0.25 ug.mL-1 10.1128/aac.00695-08
Mycolicibacterium mageritense Mycolicibacterium mageritense MIC 0.03 ug.mL-1 10.1128/aac.00695-08
Mycolicibacterium peregrinum Mycolicibacterium peregrinum MIC50 0.06 ug.mL-1 10.1128/aac.00695-08
Mycolicibacterium peregrinum Mycolicibacterium peregrinum MIC90 0.06 ug.mL-1 10.1128/aac.00695-08
Mycolicibacterium smegmatis Mycolicibacterium smegmatis MIC 0.03 ug.mL-1 10.1128/aac.00695-08
Mycoplasmoides pneumoniae Mycoplasmoides pneumoniae Activity nan None 10.1128/aac.00979-08
Mycoplasmoides pneumoniae Mycoplasmoides pneumoniae MIC 0.06 ug.mL-1 10.1128/aac.00979-08
Nocardia brasiliensis Nocardia brasiliensis MIC 6e-05 ug.mL-1 10.1128/aac.01102-06
Nocardia carnea Nocardia carnea MIC 6e-05 ug.mL-1 10.1128/aac.01102-06
Nocardia cyriacigeorgica Nocardia cyriacigeorgica MIC 6e-05 ug.mL-1 10.1128/aac.01102-06
Nocardia farcinica Nocardia farcinica MIC 0.001 ug.mL-1 10.1128/aac.01102-06
Nocardia nova Nocardia nova MIC 0.0005 ug.mL-1 10.1128/aac.01102-06
Nocardia otitidiscaviarum Nocardia otitidiscaviarum MIC 6e-05 ug.mL-1 10.1128/aac.01102-06
Nocardia sp. Nocardia sp. MIC 6e-05 ug.mL-1 10.1128/aac.01102-06
Nocardia transvalensis Nocardia transvalensis MIC 0.002 ug.mL-1 10.1128/aac.01102-06
Parabacteroides distasonis Parabacteroides distasonis Activity 2.1 % 10.1128/aac.01435-06
Parabacteroides distasonis Parabacteroides distasonis Activity 8.3 % 10.1128/aac.00081-08
Parabacteroides distasonis Parabacteroides distasonis MIC 0.125 ug.mL-1 10.1128/aac.00081-08
Parabacteroides distasonis Parabacteroides distasonis MIC 2.09 ug.mL-1 10.1128/aac.01435-06
Parabacteroides distasonis Parabacteroides distasonis MIC50 2.0 ug.mL-1 10.1128/aac.00081-08
Parabacteroides distasonis Parabacteroides distasonis MIC90 8.0 ug.mL-1 10.1128/aac.00081-08
Parabacteroides distasonis Parabacteroides distasonis MIC90 8.0 ug.mL-1 10.1128/aac.01435-06
Parabacteroides merdae Parabacteroides merdae Activity 7.2 % 10.1128/aac.01435-06
Parabacteroides merdae Parabacteroides merdae Activity 10.5 % 10.1128/aac.00081-08
Parabacteroides merdae Parabacteroides merdae MIC 0.125 ug.mL-1 10.1128/aac.00081-08
Parabacteroides merdae Parabacteroides merdae MIC 1.51 ug.mL-1 10.1128/aac.01435-06
Parabacteroides merdae Parabacteroides merdae MIC50 1.0 ug.mL-1 10.1128/aac.00081-08
Parabacteroides merdae Parabacteroides merdae MIC90 8.0 ug.mL-1 10.1128/aac.00081-08
Parabacteroides merdae Parabacteroides merdae MIC90 8.0 ug.mL-1 10.1128/aac.01435-06
Phocaeicola vulgatus Phocaeicola vulgatus Activity 1.6 % 10.1128/aac.01435-06
Phocaeicola vulgatus Phocaeicola vulgatus Activity 6.1 % 10.1128/aac.00081-08
Phocaeicola vulgatus Phocaeicola vulgatus MIC 0.125 ug.mL-1 10.1128/aac.00081-08
Phocaeicola vulgatus Phocaeicola vulgatus MIC 1.05 ug.mL-1 10.1128/aac.01435-06
Phocaeicola vulgatus Phocaeicola vulgatus MIC50 0.5 ug.mL-1 10.1128/aac.00081-08
Phocaeicola vulgatus Phocaeicola vulgatus MIC90 4.0 ug.mL-1 10.1128/aac.01435-06
Phocaeicola vulgatus Phocaeicola vulgatus MIC90 8.0 ug.mL-1 10.1128/aac.00081-08
Plasmodium falciparum Plasmodium falciparum IC50 699.11 nM 10.1128/aac.00312-09
Plasmodium falciparum Plasmodium falciparum IC90 5905.83 nM 10.1128/aac.00312-09
Plasmodium falciparum Plasmodium falciparum IC99 12416.87 nM 10.1128/aac.00312-09
Plasmodium falciparum Plasmodium falciparum Ratio IC50 49.0 None 10.1128/aac.00312-09
Pluralibacter gergoviae Pluralibacter gergoviae MIC 0.25 ug.mL-1 10.1128/aac.01114-07
Prescottella equi Prescottella equi MIC 0.015 ug.mL-1 10.1128/aac.01129-07
Prescottella equi Prescottella equi MIC50 0.25 ug.mL-1 10.1128/aac.01129-07
Prescottella equi Prescottella equi MIC90 0.5 ug.mL-1 10.1128/aac.01129-07
Proteus mirabilis Proteus mirabilis MIC 0.12 ug.mL-1 10.1128/aac.00484-10
Proteus mirabilis Proteus mirabilis MIC 0.5 ug.mL-1 10.1128/aac.00883-08
Proteus mirabilis Proteus mirabilis MIC 1.0 ug.mL-1 10.1128/aac.01197-09
Proteus mirabilis Proteus mirabilis MIC 2.0 ug.mL-1 10.1128/aac.00883-08
Proteus mirabilis Proteus mirabilis MIC 2.0 ug.mL-1 10.1128/aac.01084-06
Proteus mirabilis Proteus mirabilis MIC 4.0 ug.mL-1 10.1021/acs.jmedchem.5b00262
Proteus mirabilis Proteus mirabilis MIC 4.0 ug.mL-1 10.1021/acs.jmedchem.6b01903
Proteus mirabilis Proteus mirabilis MIC50 0.5 ug.mL-1 10.1128/aac.00484-10
Proteus mirabilis Proteus mirabilis MIC50 2.0 ug.mL-1 10.1128/aac.00883-08
Proteus mirabilis Proteus mirabilis MIC50 2.0 ug.mL-1 10.1128/aac.01197-09
Proteus mirabilis Proteus mirabilis MIC50 4.0 ug.mL-1 10.1128/aac.00572-10
Proteus mirabilis Proteus mirabilis MIC90 4.0 ug.mL-1 10.1021/acs.jmedchem.9b01605
Proteus mirabilis Proteus mirabilis MIC90 4.0 ug.mL-1 10.1128/aac.01197-09
Proteus mirabilis Proteus mirabilis MIC90 8.0 ug.mL-1 10.1128/aac.00572-10
Proteus mirabilis Proteus mirabilis MIC90 16.0 ug.mL-1 10.1128/aac.00883-08
Proteus mirabilis Proteus mirabilis MIC90 32.0 ug.mL-1 10.1128/aac.00484-10
Pseudomonas aeruginosa Pseudomonas aeruginosa Activity 0.0 % 10.1128/aac.01538-07
Pseudomonas aeruginosa Pseudomonas aeruginosa Activity 0.4 % 10.1128/aac.01538-07
Pseudomonas aeruginosa Pseudomonas aeruginosa Activity 2.0 % 10.1128/aac.01538-07
Pseudomonas aeruginosa Pseudomonas aeruginosa Activity 3.9 % 10.1128/aac.01538-07
Pseudomonas aeruginosa Pseudomonas aeruginosa Activity 4.2 deltalog10CFU 10.1021/acs.jmedchem.6b01903
Pseudomonas aeruginosa Pseudomonas aeruginosa Inhibition nan % 10.1128/aac.01452-08
Pseudomonas aeruginosa Pseudomonas aeruginosa MBC 8.0 ug ml-1 10.1128/aac.01452-08
Pseudomonas aeruginosa Pseudomonas aeruginosa MBC 32.0 ug ml-1 10.1128/aac.01452-08
Pseudomonas aeruginosa Pseudomonas aeruginosa MBC 128.0 ug ml-1 10.1128/aac.01452-08
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 0.25 ug.mL-1 10.1128/aac.00484-10
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 2.0 ug.mL-1 10.1128/aac.01197-09
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 2.0 ug.mL-1 10.1128/aac.01452-08
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 8.0 ug.mL-1 10.1021/acs.jmedchem.9b00720
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 8.0 ug.mL-1 10.1021/jm1015395
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 8.0 ug.mL-1 10.1128/aac.00899-09
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 8.0 ug.mL-1 10.1128/aac.01084-06
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 8.0 ug.mL-1 10.1128/aac.01452-08
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 16.0 ug.mL-1 10.1021/acs.jmedchem.5b00262
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 16.0 ug.mL-1 10.1021/acs.jmedchem.6b01903
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 16.0 ug.mL-1 10.1021/jm201465w
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 16.0 ug.mL-1 10.1128/aac.01405-06
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 16.0 ug.mL-1 10.1128/aac.01452-08
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 32.0 ug.mL-1 10.1128/aac.01452-08
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC50 0.5 ug.mL-1 10.1128/aac.00484-10
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC50 8.0 ug.mL-1 10.1128/aac.01197-09
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC50 16.0 ug.mL-1 10.1128/aac.00572-10
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC90 8.0 ug.mL-1 10.1128/aac.01197-09
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC90 16.0 ug.mL-1 10.1021/acs.jmedchem.5b01698
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC90 16.0 ug.mL-1 10.1021/acs.jmedchem.9b01605
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC90 16.0 ug.mL-1 10.1128/aac.00572-10
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC90 32.0 ug.mL-1 10.1128/aac.00484-10
Rattus norvegicus Androgen Receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Rattus norvegicus Cyclooxygenase-1 AC50 160.0 nM 10.1038/s41467-023-40064-9
Rattus norvegicus GABA receptor alpha-1 subunit AC50 30000.0 nM 10.1038/s41467-023-40064-9
Rattus norvegicus Glutamate (NMDA) receptor subunit zeta 1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Rattus norvegicus Plasma Drug uptake 1.87 ug ml-1 10.1128/aac.01612-08
Rattus norvegicus Rattus norvegicus AUC 107.0 ng.hr.mL-1 10.1021/jm201465w
Rattus norvegicus Rattus norvegicus AUC 1052.0 ng.hr.mL-1 10.1021/jm1015389
Rattus norvegicus Rattus norvegicus AUC 1052.0 ng.hr.mL-1 10.1021/jm1015395
Rattus norvegicus Rattus norvegicus AUC 1052.0 ng.hr.mL-1 10.1021/jm201465w
Rattus norvegicus Rattus norvegicus CL 15.48 mL.min-1.kg-1 10.1021/jm1015389
Rattus norvegicus Rattus norvegicus CL 15.48 mL.min-1.kg-1 10.1021/jm201465w
Rattus norvegicus Rattus norvegicus CL 15.5 mL.min-1.kg-1 10.1021/jm1015395
Rattus norvegicus Rattus norvegicus Cmax 730.8 nM 10.1021/jm1015395
Rattus norvegicus Rattus norvegicus F 1.0 % 10.1021/jm201465w
Rattus norvegicus Rattus norvegicus F 1.1 % 10.1021/jm1015389
Rattus norvegicus Rattus norvegicus F 1.1 % 10.1021/jm1015395
Rattus norvegicus Rattus norvegicus F 1.1 % 10.1021/jm201467r
Rattus norvegicus Rattus norvegicus T1/2 3.98 hr 10.1021/jm201465w
Rattus norvegicus Rattus norvegicus T1/2 4.6 hr 10.1021/jm1015389
Rattus norvegicus Rattus norvegicus T1/2 4.6 hr 10.1021/jm1015395
Rattus norvegicus Rattus norvegicus T1/2 4.6 hr 10.1021/jm201465w
Rattus norvegicus Rattus norvegicus Vd 6.119 L.kg-1 10.1021/jm1015389
Rattus norvegicus Rattus norvegicus Vd 6.12 L.kg-1 10.1021/jm1015395
Rattus norvegicus Rattus norvegicus Vd 6.12 L.kg-1 10.1021/jm201465w
Rattus norvegicus Voltage-gated L-type calcium channel alpha-1C subunit AC50 30000.0 nM 10.1038/s41467-023-40064-9
Salmonella Salmonella Activity 0.0 % 10.1128/aac.00002-08
Salmonella Salmonella Activity 100.0 % 10.1128/aac.00002-08
Salmonella enterica Salmonella enterica MIC 0.25 ug.mL-1 10.1128/aac.00993-09
Salmonella enterica subsp. enterica serovar Typhimurium Salmonella typhimurium Activity 0.0 % 10.1128/aac.00002-08
Salmonella enterica subsp. enterica serovar Typhimurium Salmonella typhimurium Activity 1.6 % 10.1128/aac.00002-08
Salmonella enterica subsp. enterica serovar Typhimurium Salmonella typhimurium Activity 98.4 % 10.1128/aac.00002-08
Salmonella enterica subsp. enterica serovar Typhimurium Salmonella typhimurium Activity 100.0 % 10.1128/aac.00002-08
Serratia marcescens Serratia marcescens MIC 0.25 ug.mL-1 10.1128/aac.00484-10
Serratia marcescens Serratia marcescens MIC 0.5 ug.mL-1 10.1128/aac.01114-07
Serratia marcescens Serratia marcescens MIC 1.0 ug.mL-1 10.1128/aac.01084-06
Serratia marcescens Serratia marcescens MIC50 0.5 ug.mL-1 10.1128/aac.00484-10
Serratia marcescens Serratia marcescens MIC90 2.0 ug.mL-1 10.1021/acs.jmedchem.9b01605
Serratia marcescens Serratia marcescens MIC90 2.0 ug.mL-1 10.1128/aac.00484-10
Serratia sp. Serratia sp. MIC50 2.0 ug.mL-1 10.1128/aac.00572-10
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Hit score 0.1712 None 10.1101/2020.04.21.054387
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 IC50 19952.62 nM 10.6019/CHEMBL4651402
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 IC50 20000.0 nM 10.6019/CHEMBL4651402
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Inhibition index 0.08555 None 10.1101/2020.04.03.023846
Staphylococcus Staphylococcus Activity nan None 10.1128/aac.00275-10
Staphylococcus Staphylococcus MIC 3e-05 ug.mL-1 10.1128/aac.00275-10
Staphylococcus Staphylococcus MIC 6e-05 ug.mL-1 10.1128/aac.00275-10
Staphylococcus Staphylococcus MIC 0.06 ug.mL-1 10.1128/aac.01197-09
Staphylococcus Staphylococcus MIC50 0.25 ug.mL-1 10.1128/aac.01197-09
Staphylococcus Staphylococcus MIC90 0.5 ug.mL-1 10.1128/aac.01197-09
Staphylococcus Staphylococcus Ratio 0.83 None 10.1128/aac.00275-10
Staphylococcus Staphylococcus Ratio 0.86 None 10.1128/aac.00275-10
Staphylococcus Staphylococcus Ratio 0.93 None 10.1128/aac.00275-10
Staphylococcus Staphylococcus Ratio 0.98 None 10.1128/aac.00275-10
Staphylococcus Staphylococcus Ratio 0.99 None 10.1128/aac.00275-10
Staphylococcus Staphylococcus Ratio 1.1 None 10.1128/aac.00275-10
Staphylococcus Staphylococcus Ratio 1.12 None 10.1128/aac.00275-10
Staphylococcus Staphylococcus Ratio 1.31 None 10.1128/aac.00275-10
Staphylococcus Staphylococcus Ratio 1.32 None 10.1128/aac.00275-10
Staphylococcus aureus Staphylococcus aureus Activity 0.0 % 10.1128/aac.00206-09
Staphylococcus aureus Staphylococcus aureus Activity 0.0 % 10.1128/aac.01538-07
Staphylococcus aureus Staphylococcus aureus Activity 3.0 mg kg-1 10.1021/jm201465w
Staphylococcus aureus Staphylococcus aureus Activity 17.3 mg kg-1 10.1021/jm201465w
Staphylococcus aureus Staphylococcus aureus Activity 44.4 % 10.1128/aac.00206-09
Staphylococcus aureus Staphylococcus aureus Activity 54.3 % 10.1128/aac.00206-09
Staphylococcus aureus Staphylococcus aureus Activity 90.2 % 10.1128/aac.00206-09
Staphylococcus aureus Staphylococcus aureus Activity 92.6 % 10.1128/aac.00206-09
Staphylococcus aureus Staphylococcus aureus Activity 100.0 % 10.1128/aac.00206-09
Staphylococcus aureus Staphylococcus aureus Activity nan None 10.1128/aac.00350-06
Staphylococcus aureus Staphylococcus aureus Activity nan None 10.1128/aac.00893-06
Staphylococcus aureus Staphylococcus aureus Activity nan None 10.1128/aac.00922-07
Staphylococcus aureus Staphylococcus aureus Activity nan None 10.1128/aac.01145-08
Staphylococcus aureus Staphylococcus aureus CFU 1.5 None 10.1128/aac.00647-08
Staphylococcus aureus Staphylococcus aureus ED50 0.45 mg.kg-1 10.1016/j.bmc.2016.07.029
Staphylococcus aureus Staphylococcus aureus ED50 0.46 mg.kg-1 10.1016/j.bmc.2016.07.029
Staphylococcus aureus Staphylococcus aureus FC 1.01 None 10.1128/aac.00155-09
Staphylococcus aureus Staphylococcus aureus FC 1.03 None 10.1128/aac.00155-09
Staphylococcus aureus Staphylococcus aureus FC 1.09 None 10.1128/aac.00155-09
Staphylococcus aureus Staphylococcus aureus FC 1.14 None 10.1128/aac.00155-09
Staphylococcus aureus Staphylococcus aureus FC 1.17 None 10.1128/aac.00155-09
Staphylococcus aureus Staphylococcus aureus FC 1.18 None 10.1128/aac.00155-09
Staphylococcus aureus Staphylococcus aureus FC 1.2 None 10.1128/aac.00155-09
Staphylococcus aureus Staphylococcus aureus FC 1.22 None 10.1128/aac.00155-09
Staphylococcus aureus Staphylococcus aureus FC 1.23 None 10.1128/aac.00155-09
Staphylococcus aureus Staphylococcus aureus FC 1.32 None 10.1128/aac.00155-09
Staphylococcus aureus Staphylococcus aureus FC 1.51 None 10.1128/aac.00155-09
Staphylococcus aureus Staphylococcus aureus FC 1.53 None 10.1128/aac.00155-09
Staphylococcus aureus Staphylococcus aureus FC 1.55 None 10.1128/aac.00155-09
Staphylococcus aureus Staphylococcus aureus FC 1.58 None 10.1128/aac.00155-09
Staphylococcus aureus Staphylococcus aureus FC 1.6 None 10.1128/aac.00155-09
Staphylococcus aureus Staphylococcus aureus FC 1.64 None 10.1128/aac.00155-09
Staphylococcus aureus Staphylococcus aureus FC 1.72 None 10.1128/aac.00155-09
Staphylococcus aureus Staphylococcus aureus FC 1.75 None 10.1128/aac.00155-09
Staphylococcus aureus Staphylococcus aureus FC 1.86 None 10.1128/aac.00155-09
Staphylococcus aureus Staphylococcus aureus FC 1.93 None 10.1128/aac.00155-09
Staphylococcus aureus Staphylococcus aureus FC 1.96 None 10.1128/aac.00155-09
Staphylococcus aureus Staphylococcus aureus FC 2.0 None 10.1128/aac.00922-07
Staphylococcus aureus Staphylococcus aureus FC 2.02 None 10.1128/aac.00155-09
Staphylococcus aureus Staphylococcus aureus FC 2.04 None 10.1128/aac.00155-09
Staphylococcus aureus Staphylococcus aureus FC 2.06 None 10.1128/aac.00155-09
Staphylococcus aureus Staphylococcus aureus FC 2.08 None 10.1128/aac.00155-09
Staphylococcus aureus Staphylococcus aureus FC 2.1 None 10.1128/aac.00155-09
Staphylococcus aureus Staphylococcus aureus FC 2.11 None 10.1128/aac.00155-09
Staphylococcus aureus Staphylococcus aureus FC 2.15 None 10.1128/aac.00155-09
Staphylococcus aureus Staphylococcus aureus FC 2.18 None 10.1128/aac.00155-09
Staphylococcus aureus Staphylococcus aureus FC 2.19 None 10.1128/aac.00155-09
Staphylococcus aureus Staphylococcus aureus FC 2.23 None 10.1128/aac.00155-09
Staphylococcus aureus Staphylococcus aureus FC 2.26 None 10.1128/aac.00155-09
Staphylococcus aureus Staphylococcus aureus FC 2.29 None 10.1128/aac.00155-09
Staphylococcus aureus Staphylococcus aureus FC 2.3 None 10.1128/aac.00155-09
Staphylococcus aureus Staphylococcus aureus FC 2.35 None 10.1128/aac.00155-09
Staphylococcus aureus Staphylococcus aureus FC 2.37 None 10.1128/aac.00155-09
Staphylococcus aureus Staphylococcus aureus FC 2.39 None 10.1128/aac.00155-09
Staphylococcus aureus Staphylococcus aureus FC 2.44 None 10.1128/aac.00155-09
Staphylococcus aureus Staphylococcus aureus FC 2.46 None 10.1128/aac.00155-09
Staphylococcus aureus Staphylococcus aureus FC 2.49 None 10.1128/aac.00155-09
Staphylococcus aureus Staphylococcus aureus FC 2.59 None 10.1128/aac.00155-09
Staphylococcus aureus Staphylococcus aureus FC 2.63 None 10.1128/aac.00155-09
Staphylococcus aureus Staphylococcus aureus FC 2.64 None 10.1128/aac.00155-09
Staphylococcus aureus Staphylococcus aureus FC 2.66 None 10.1128/aac.00155-09
Staphylococcus aureus Staphylococcus aureus FC 2.79 None 10.1128/aac.00155-09
Staphylococcus aureus Staphylococcus aureus FC 2.84 None 10.1128/aac.00155-09
Staphylococcus aureus Staphylococcus aureus FC 2.85 None 10.1128/aac.00155-09
Staphylococcus aureus Staphylococcus aureus FC 3.03 None 10.1128/aac.00155-09
Staphylococcus aureus Staphylococcus aureus FC 3.14 None 10.1128/aac.00155-09
Staphylococcus aureus Staphylococcus aureus FC 3.15 None 10.1128/aac.00155-09
Staphylococcus aureus Staphylococcus aureus FC 3.23 None 10.1128/aac.00155-09
Staphylococcus aureus Staphylococcus aureus FC 3.27 None 10.1128/aac.00155-09
Staphylococcus aureus Staphylococcus aureus FC 3.28 None 10.1128/aac.00155-09
Staphylococcus aureus Staphylococcus aureus FC 3.31 None 10.1128/aac.00155-09
Staphylococcus aureus Staphylococcus aureus FC 3.42 None 10.1128/aac.00155-09
Staphylococcus aureus Staphylococcus aureus FC 3.48 None 10.1128/aac.00155-09
Staphylococcus aureus Staphylococcus aureus FC 3.53 None 10.1128/aac.00155-09
Staphylococcus aureus Staphylococcus aureus FC 3.7 None 10.1128/aac.00155-09
Staphylococcus aureus Staphylococcus aureus FC 3.91 None 10.1128/aac.00155-09
Staphylococcus aureus Staphylococcus aureus FC 4.0 None 10.1128/aac.00155-09
Staphylococcus aureus Staphylococcus aureus FC 4.34 None 10.1128/aac.00155-09
Staphylococcus aureus Staphylococcus aureus FC 4.38 None 10.1128/aac.00155-09
Staphylococcus aureus Staphylococcus aureus FC 4.77 None 10.1128/aac.00155-09
Staphylococcus aureus Staphylococcus aureus FC 5.08 None 10.1128/aac.00155-09
Staphylococcus aureus Staphylococcus aureus FC 5.16 None 10.1128/aac.00155-09
Staphylococcus aureus Staphylococcus aureus FC 5.34 None 10.1128/aac.00155-09
Staphylococcus aureus Staphylococcus aureus FC 5.52 None 10.1128/aac.00155-09
Staphylococcus aureus Staphylococcus aureus FC 5.59 None 10.1128/aac.00155-09
Staphylococcus aureus Staphylococcus aureus FC 6.29 None 10.1128/aac.00155-09
Staphylococcus aureus Staphylococcus aureus FC 6.99 None 10.1128/aac.00155-09
Staphylococcus aureus Staphylococcus aureus FC 7.41 None 10.1128/aac.00155-09
Staphylococcus aureus Staphylococcus aureus FC 7.5 None 10.1128/aac.00155-09
Staphylococcus aureus Staphylococcus aureus FC 7.68 None 10.1128/aac.00155-09
Staphylococcus aureus Staphylococcus aureus FC 8.61 None 10.1128/aac.00155-09
Staphylococcus aureus Staphylococcus aureus FC 9.12 None 10.1128/aac.00155-09
Staphylococcus aureus Staphylococcus aureus FC 10.0 None 10.1128/aac.00155-09
Staphylococcus aureus Staphylococcus aureus FC 10.51 None 10.1128/aac.00155-09
Staphylococcus aureus Staphylococcus aureus FC 11.01 None 10.1128/aac.00155-09
Staphylococcus aureus Staphylococcus aureus FC 11.03 None 10.1128/aac.00155-09
Staphylococcus aureus Staphylococcus aureus FC 12.06 None 10.1128/aac.00155-09
Staphylococcus aureus Staphylococcus aureus FC 12.75 None 10.1128/aac.00155-09
Staphylococcus aureus Staphylococcus aureus FC 13.06 None 10.1128/aac.00155-09
Staphylococcus aureus Staphylococcus aureus FC 13.38 None 10.1128/aac.00155-09
Staphylococcus aureus Staphylococcus aureus FC 13.76 None 10.1128/aac.00155-09
Staphylococcus aureus Staphylococcus aureus FC 14.86 None 10.1128/aac.00155-09
Staphylococcus aureus Staphylococcus aureus FC 19.87 None 10.1128/aac.00155-09
Staphylococcus aureus Staphylococcus aureus log10cfu -1.11 None 10.1128/aac.01145-08
Staphylococcus aureus Staphylococcus aureus log10cfu 0.8 None 10.1128/aac.01145-08
Staphylococcus aureus Staphylococcus aureus log10cfu 1.0 None 10.1128/aac.01145-08
Staphylococcus aureus Staphylococcus aureus log10cfu 1.6 None 10.1128/aac.00647-08
Staphylococcus aureus Staphylococcus aureus log10cfu 1.8 None 10.1128/aac.00647-08
Staphylococcus aureus Staphylococcus aureus log10cfu 1.9 None 10.1128/aac.00647-08
Staphylococcus aureus Staphylococcus aureus log10CFU/ml -1.75 None 10.1128/aac.01145-08
Staphylococcus aureus Staphylococcus aureus log10CFU/ml -1.1 None 10.1128/aac.00647-08
Staphylococcus aureus Staphylococcus aureus log10CFU/ml 0.1 None 10.1128/aac.00647-08
Staphylococcus aureus Staphylococcus aureus log10CFU/ml 0.5 None 10.1128/aac.00647-08
Staphylococcus aureus Staphylococcus aureus log10CFU/ml 0.62 None 10.1128/aac.01612-08
Staphylococcus aureus Staphylococcus aureus log10CFU/ml 1.31 None 10.1128/aac.01145-08
Staphylococcus aureus Staphylococcus aureus log10CFU/ml 1.4 None 10.1128/aac.00647-08
Staphylococcus aureus Staphylococcus aureus log10CFU/ml 1.8 None 10.1128/aac.00647-08
Staphylococcus aureus Staphylococcus aureus log10CFU/ml 2.0 None 10.1128/aac.00647-08
Staphylococcus aureus Staphylococcus aureus log10CFU/ml 2.0 None 10.1128/aac.01612-08
Staphylococcus aureus Staphylococcus aureus log10CFU/ml 2.1 None 10.1128/aac.00647-08
Staphylococcus aureus Staphylococcus aureus log10CFU/ml 2.3 None 10.1128/aac.00647-08
Staphylococcus aureus Staphylococcus aureus log10CFU/ml 6.92 None 10.1128/aac.01612-08
Staphylococcus aureus Staphylococcus aureus MIC 6e-05 ug.mL-1 10.1128/aac.00275-10
Staphylococcus aureus Staphylococcus aureus MIC 0.000125 ug.mL-1 10.1128/aac.00275-10
Staphylococcus aureus Staphylococcus aureus MIC 0.001 ug.mL-1 10.1128/aac.00275-10
Staphylococcus aureus Staphylococcus aureus MIC 0.016 ug.mL-1 10.1021/jm1015389
Staphylococcus aureus Staphylococcus aureus MIC 0.032 ug.mL-1 10.1128/aac.00206-09
Staphylococcus aureus Staphylococcus aureus MIC 0.06 ug.mL-1 10.1016/j.bmc.2016.07.029
Staphylococcus aureus Staphylococcus aureus MIC 0.06 ug.mL-1 10.1128/aac.01084-06
Staphylococcus aureus Staphylococcus aureus MIC 0.06 ug.mL-1 10.1128/aac.01197-09
Staphylococcus aureus Staphylococcus aureus MIC 0.0625 ug.mL-1 10.1021/acs.jmedchem.5b00262
Staphylococcus aureus Staphylococcus aureus MIC 0.0625 ug.mL-1 10.1021/acs.jmedchem.6b01903
Staphylococcus aureus Staphylococcus aureus MIC 0.0625 ug.mL-1 10.1021/jm1015395
Staphylococcus aureus Staphylococcus aureus MIC 0.0625 ug.mL-1 10.1021/jm201465w
Staphylococcus aureus Staphylococcus aureus MIC 0.063 ug.mL-1 10.1021/jm1015389
Staphylococcus aureus Staphylococcus aureus MIC 0.063 ug.mL-1 10.1021/jm201467r
Staphylococcus aureus Staphylococcus aureus MIC 0.064 ug.mL-1 10.1128/aac.00206-09
Staphylococcus aureus Staphylococcus aureus MIC 0.09 ug.mL-1 10.1128/aac.00307-09
Staphylococcus aureus Staphylococcus aureus MIC 0.12 ug mg-1 10.1016/s0960-894x(99)00216-4
Staphylococcus aureus Staphylococcus aureus MIC 0.12 ug.mL-1 10.1016/j.bmcl.2005.09.078
Staphylococcus aureus Staphylococcus aureus MIC 0.12 ug.mL-1 10.1128/aac.01122-08
Staphylococcus aureus Staphylococcus aureus MIC 0.12 ug.mL-1 10.1128/aac.01197-09
Staphylococcus aureus Staphylococcus aureus MIC 0.125 ug.mL-1 10.1016/j.bmc.2016.07.029
Staphylococcus aureus Staphylococcus aureus MIC 0.125 ug.mL-1 10.1021/acs.jmedchem.5b00262
Staphylococcus aureus Staphylococcus aureus MIC 0.125 ug.mL-1 10.1021/acs.jmedchem.6b01903
Staphylococcus aureus Staphylococcus aureus MIC 0.125 ug.mL-1 10.1021/jm1015389
Staphylococcus aureus Staphylococcus aureus MIC 0.125 ug.mL-1 10.1021/jm1015395
Staphylococcus aureus Staphylococcus aureus MIC 0.125 ug.mL-1 10.1021/jm201465w
Staphylococcus aureus Staphylococcus aureus MIC 0.125 ug.mL-1 10.1128/aac.00062-10
Staphylococcus aureus Staphylococcus aureus MIC 0.125 ug.mL-1 10.1128/aac.00206-09
Staphylococcus aureus Staphylococcus aureus MIC 0.125 ug.mL-1 10.1128/aac.00647-08
Staphylococcus aureus Staphylococcus aureus MIC 0.125 ug.mL-1 10.1128/aac.00922-07
Staphylococcus aureus Staphylococcus aureus MIC 0.125 ug.mL-1 10.1128/aac.00985-09
Staphylococcus aureus Staphylococcus aureus MIC 0.125 ug.mL-1 10.1128/aac.01145-08
Staphylococcus aureus Staphylococcus aureus MIC 0.13 ug.mL-1 10.1021/jm201467r
Staphylococcus aureus Staphylococcus aureus MIC 0.25 ug mg-1 10.1016/s0960-894x(99)00216-4
Staphylococcus aureus Staphylococcus aureus MIC 0.25 ug.mL-1 10.1016/j.bmc.2020.115776
Staphylococcus aureus Staphylococcus aureus MIC 0.25 ug.mL-1 10.1016/j.bmcl.2005.09.078
Staphylococcus aureus Staphylococcus aureus MIC 0.25 ug.mL-1 10.1021/jm201465w
Staphylococcus aureus Staphylococcus aureus MIC 0.25 ug.mL-1 10.1128/aac.00062-10
Staphylococcus aureus Staphylococcus aureus MIC 0.25 ug.mL-1 10.1128/aac.00206-09
Staphylococcus aureus Staphylococcus aureus MIC 0.25 ug.mL-1 10.1128/aac.00985-09
Staphylococcus aureus Staphylococcus aureus MIC 0.5 ug mg-1 10.1016/s0960-894x(99)00216-4
Staphylococcus aureus Staphylococcus aureus MIC 0.5 ug.mL-1 10.1016/j.bmc.2020.115776
Staphylococcus aureus Staphylococcus aureus MIC 0.5 ug.mL-1 10.1016/j.bmcl.2005.09.078
Staphylococcus aureus Staphylococcus aureus MIC 0.5 ug.mL-1 10.1128/aac.00062-10
Staphylococcus aureus Staphylococcus aureus MIC 0.5 ug.mL-1 10.1128/aac.00206-09
Staphylococcus aureus Staphylococcus aureus MIC 0.5 ug.mL-1 10.1128/aac.00647-08
Staphylococcus aureus Staphylococcus aureus MIC 0.5 ug.mL-1 10.1128/aac.00985-09
Staphylococcus aureus Staphylococcus aureus MIC 0.5 ug.mL-1 10.1128/aac.01612-08
Staphylococcus aureus Staphylococcus aureus MIC 0.75 ug.mL-1 10.1128/aac.01098-07
Staphylococcus aureus Staphylococcus aureus MIC 1.0 ug.mL-1 10.1128/aac.01098-07
Staphylococcus aureus Staphylococcus aureus MIC nan None 10.1016/j.bmcl.2005.09.078
Staphylococcus aureus Staphylococcus aureus MIC100 0.25 ug ml-1 10.1021/acs.jmedchem.1c01073
Staphylococcus aureus Staphylococcus aureus MIC100 0.5 ug ml-1 10.1021/acs.jmedchem.1c01073
Staphylococcus aureus Staphylococcus aureus MIC100 1.0 ug ml-1 10.1021/acs.jmedchem.1c01073
Staphylococcus aureus Staphylococcus aureus MIC50 0.063 ug.mL-1 10.1021/jm1015389
Staphylococcus aureus Staphylococcus aureus MIC50 0.12 ug.mL-1 10.1128/aac.01197-09
Staphylococcus aureus Staphylococcus aureus MIC50 0.125 ug.mL-1 10.1128/aac.00206-09
Staphylococcus aureus Staphylococcus aureus MIC50 0.13 ug.mL-1 10.1128/aac.00307-09
Staphylococcus aureus Staphylococcus aureus MIC50 0.19 ug.mL-1 10.1128/aac.00307-09
Staphylococcus aureus Staphylococcus aureus MIC50 0.25 ug.mL-1 10.1016/j.bmc.2020.115776
Staphylococcus aureus Staphylococcus aureus MIC50 0.25 ug.mL-1 10.1128/aac.00206-09
Staphylococcus aureus Staphylococcus aureus MIC50 0.25 ug.mL-1 10.1128/aac.01197-09
Staphylococcus aureus Staphylococcus aureus MIC90 0.12 ug.mL-1 10.1128/aac.01051-10
Staphylococcus aureus Staphylococcus aureus MIC90 0.2 ug.mL-1 10.1128/aac.00307-09
Staphylococcus aureus Staphylococcus aureus MIC90 0.25 ug.mL-1 10.1128/aac.00206-09
Staphylococcus aureus Staphylococcus aureus MIC90 0.25 ug.mL-1 10.1128/aac.00307-09
Staphylococcus aureus Staphylococcus aureus MIC90 0.25 ug.mL-1 10.1128/aac.01197-09
Staphylococcus aureus Staphylococcus aureus MIC90 0.5 ug.mL-1 10.1128/aac.01197-09
Staphylococcus aureus Staphylococcus aureus MIC90 1.0 ug.mL-1 10.1021/jm1015389
Staphylococcus aureus Staphylococcus aureus MIC90 2.0 ug.mL-1 10.1016/j.bmc.2020.115776
Staphylococcus aureus Staphylococcus aureus PAE 0.2 hr 10.1128/aac.01122-08
Staphylococcus aureus Staphylococcus aureus PAE 0.9 hr 10.1128/aac.01122-08
Staphylococcus aureus Staphylococcus aureus PAE 2.0 hr 10.1128/aac.01122-08
Staphylococcus aureus Staphylococcus aureus PAE 2.9 hr 10.1128/aac.01122-08
Staphylococcus aureus Staphylococcus aureus PAE 3.2 hr 10.1128/aac.01122-08
Staphylococcus aureus Staphylococcus aureus PAE 3.6 hr 10.1128/aac.01122-08
Staphylococcus aureus Staphylococcus aureus PAE 3.7 hr 10.1128/aac.01122-08
Staphylococcus aureus Staphylococcus aureus PAE 4.0 hr 10.1128/aac.01122-08
Staphylococcus aureus Staphylococcus aureus PAE 4.9 hr 10.1128/aac.01122-08
Staphylococcus aureus Staphylococcus aureus PAE 5.2 hr 10.1128/aac.01122-08
Staphylococcus aureus Staphylococcus aureus PAE 5.6 hr 10.1128/aac.01122-08
Staphylococcus aureus Staphylococcus aureus PAE 6.6 hr 10.1128/aac.01122-08
Staphylococcus aureus Staphylococcus aureus PAE 6.7 hr 10.1128/aac.01122-08
Staphylococcus aureus Staphylococcus aureus PAE 6.9 hr 10.1128/aac.01122-08
Staphylococcus aureus Staphylococcus aureus PAE 9.8 hr 10.1128/aac.01122-08
Staphylococcus aureus Staphylococcus aureus PAE 9.9 hr 10.1128/aac.01122-08
Staphylococcus aureus Staphylococcus aureus PAE 10.0 hr 10.1128/aac.01122-08
Staphylococcus aureus Staphylococcus aureus PD50 0.35 mg kg-1 10.1021/jm1015389
Staphylococcus aureus Staphylococcus aureus PD50 0.35 mg kg-1 10.1021/jm1015395
Staphylococcus aureus Staphylococcus aureus PD50 nan None 10.1021/jm1015395
Staphylococcus aureus Staphylococcus aureus Survival 0.0 % 10.1021/jm201467r
Staphylococcus aureus Staphylococcus aureus Survival 100.0 % 10.1021/jm201467r
Staphylococcus epidermidis Staphylococcus epidermidis Activity nan None 10.1128/aac.00893-06
Staphylococcus epidermidis Staphylococcus epidermidis Activity nan None 10.1128/aac.01538-07
Staphylococcus epidermidis Staphylococcus epidermidis MIC 0.000125 ug.mL-1 10.1128/aac.00275-10
Staphylococcus epidermidis Staphylococcus epidermidis MIC 0.0005 ug.mL-1 10.1128/aac.00275-10
Staphylococcus epidermidis Staphylococcus epidermidis MIC 0.002 ug.mL-1 10.1128/aac.00275-10
Staphylococcus epidermidis Staphylococcus epidermidis MIC 0.06 ug.mL-1 10.1128/aac.01197-09
Staphylococcus epidermidis Staphylococcus epidermidis MIC50 0.25 ug.mL-1 10.1128/aac.01197-09
Staphylococcus epidermidis Staphylococcus epidermidis MIC90 0.5 ug.mL-1 10.1128/aac.01197-09
Staphylococcus sp. Staphylococcus sp. MIC50 0.25 ug.mL-1 10.1128/aac.00572-10
Staphylococcus sp. Staphylococcus sp. MIC90 0.5 ug.mL-1 10.1128/aac.00572-10
Stenotrophomonas maltophilia Stenotrophomonas maltophilia MIC 2.0 ug.mL-1 10.1021/acs.jmedchem.5b00262
Stenotrophomonas maltophilia Stenotrophomonas maltophilia MIC 2.0 ug.mL-1 10.1021/acs.jmedchem.6b01903
Stenotrophomonas maltophilia Stenotrophomonas maltophilia MIC90 4.0 ug.mL-1 10.1021/acs.jmedchem.9b01605
Streptococcus agalactiae Streptococcus agalactiae MIC 0.03 ug.mL-1 10.1128/aac.01197-09
Streptococcus agalactiae Streptococcus agalactiae MIC 0.06 ug.mL-1 10.1128/aac.01084-06
Streptococcus agalactiae Streptococcus agalactiae MIC50 0.03 ug.mL-1 10.1128/aac.01197-09
Streptococcus agalactiae Streptococcus agalactiae MIC90 0.06 ug.mL-1 10.1128/aac.01197-09
Streptococcus constellatus Streptococcus constellatus MIC 0.12 ug.mL-1 10.1128/aac.01084-06
Streptococcus dysgalactiae Streptococcus dysgalactiae MIC 0.12 ug.mL-1 10.1128/aac.01084-06
Streptococcus dysgalactiae subsp. equisimilis Streptococcus dysgalactiae subsp. equisimilis MIC 0.06 ug.mL-1 10.1128/aac.01084-06
Streptococcus intermedius Streptococcus intermedius MIC 0.06 ug.mL-1 10.1128/aac.01084-06
Streptococcus pneumoniae Streptococcus pneumoniae Activity 100.0 % 10.1128/aac.01384-06
Streptococcus pneumoniae Streptococcus pneumoniae Activity nan None 10.1128/aac.01538-07
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.015 ug.mL-1 10.1128/aac.00046-08
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.015 ug.mL-1 10.1128/aac.01197-09
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.0156 ug.mL-1 10.1021/acs.jmedchem.5b00262
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.0156 ug.mL-1 10.1021/acs.jmedchem.6b01903
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.0156 ug.mL-1 10.1021/jm1015395
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.0156 ug.mL-1 10.1021/jm201465w
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.016 ug.mL-1 10.1021/jm1015389
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.016 ug.mL-1 10.1021/jm201467r
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.016 ug.mL-1 10.1128/aac.00827-07
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.03 ug.mL-1 10.1128/aac.00827-07
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.03 ug.mL-1 10.1128/aac.01122-08
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.06 ug.mL-1 10.1016/j.bmc.2020.115776
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.06 ug.mL-1 10.1128/aac.00827-07
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.06 ug.mL-1 10.1128/aac.01122-08
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.08 ug.mL-1 10.1128/aac.01197-09
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.125 ug.mL-1 10.1016/j.bmc.2016.07.029
Streptococcus pneumoniae Streptococcus pneumoniae MIC50 0.015 ug.mL-1 10.1128/aac.00046-08
Streptococcus pneumoniae Streptococcus pneumoniae MIC50 0.015 ug.mL-1 10.1128/aac.01384-06
Streptococcus pneumoniae Streptococcus pneumoniae MIC50 0.016 ug.mL-1 10.1021/jm1015389
Streptococcus pneumoniae Streptococcus pneumoniae MIC50 0.03 ug.mL-1 10.1128/aac.01197-09
Streptococcus pneumoniae Streptococcus pneumoniae MIC50 0.06 ug.mL-1 10.1128/aac.01197-09
Streptococcus pneumoniae Streptococcus pneumoniae MIC90 0.016 ug.mL-1 10.1021/jm1015389
Streptococcus pneumoniae Streptococcus pneumoniae MIC90 0.03 ug.mL-1 10.1128/aac.00046-08
Streptococcus pneumoniae Streptococcus pneumoniae MIC90 0.03 ug.mL-1 10.1128/aac.01384-06
Streptococcus pneumoniae Streptococcus pneumoniae MIC90 0.06 ug.mL-1 10.1128/aac.01197-09
Streptococcus pneumoniae Streptococcus pneumoniae PAE 0.0 hr 10.1128/aac.01122-08
Streptococcus pneumoniae Streptococcus pneumoniae PAE 0.5 hr 10.1128/aac.01122-08
Streptococcus pneumoniae Streptococcus pneumoniae PAE 0.7 hr 10.1128/aac.01122-08
Streptococcus pneumoniae Streptococcus pneumoniae PAE 0.8 hr 10.1128/aac.01122-08
Streptococcus pneumoniae Streptococcus pneumoniae PAE 1.9 hr 10.1128/aac.01122-08
Streptococcus pneumoniae Streptococcus pneumoniae PAE 3.7 hr 10.1128/aac.01122-08
Streptococcus pneumoniae Streptococcus pneumoniae PAE 4.8 hr 10.1128/aac.01122-08
Streptococcus pneumoniae Streptococcus pneumoniae PAE 5.7 hr 10.1128/aac.01122-08
Streptococcus pneumoniae Streptococcus pneumoniae PAE 5.9 hr 10.1128/aac.01122-08
Streptococcus pneumoniae Streptococcus pneumoniae PAE 6.1 hr 10.1128/aac.01122-08
Streptococcus pneumoniae Streptococcus pneumoniae PAE 6.7 hr 10.1128/aac.01122-08
Streptococcus pneumoniae Streptococcus pneumoniae PAE 7.7 hr 10.1128/aac.01122-08
Streptococcus pneumoniae Streptococcus pneumoniae PAE 8.8 hr 10.1128/aac.01122-08
Streptococcus pneumoniae Streptococcus pneumoniae PAE 8.9 hr 10.1128/aac.01122-08
Streptococcus pneumoniae Streptococcus pneumoniae PAE 9.0 hr 10.1128/aac.01122-08
Streptococcus pneumoniae Streptococcus pneumoniae PAE 10.2 hr 10.1128/aac.01122-08
Streptococcus pneumoniae Streptococcus pneumoniae PD50 0.91 mg kg-1 10.1016/j.bmc.2016.07.029
Streptococcus pyogenes Streptococcus pyogenes MIC 0.015 ug.mL-1 10.1128/aac.01197-09
Streptococcus pyogenes Streptococcus pyogenes MIC 0.025 ug.mL-1 10.1128/aac.01536-09
Streptococcus pyogenes Streptococcus pyogenes MIC 0.06 ug.mL-1 10.1128/aac.01084-06
Streptococcus pyogenes Streptococcus pyogenes MIC50 0.03 ug.mL-1 10.1128/aac.01197-09
Streptococcus pyogenes Streptococcus pyogenes MIC50 0.064 ug.mL-1 10.1128/aac.01536-09
Streptococcus pyogenes Streptococcus pyogenes MIC90 0.047 ug.mL-1 10.1128/aac.01536-09
Streptococcus pyogenes Streptococcus pyogenes MIC90 0.06 ug.mL-1 10.1128/aac.01197-09
Streptococcus viridans Streptococcus viridans MIC 0.03 ug.mL-1 10.1128/aac.01197-09
Streptococcus viridans Streptococcus viridans MIC50 0.06 ug.mL-1 10.1128/aac.01197-09
Streptococcus viridans Streptococcus viridans MIC90 0.12 ug.mL-1 10.1128/aac.01197-09
Vibrio cholerae Vibrio cholerae Activity 0.0 % 10.1128/aac.00002-08
Vibrio cholerae Vibrio cholerae Activity 100.0 % 10.1128/aac.00002-08
Vibrio parahaemolyticus Vibrio parahaemolyticus Activity 0.0 % 10.1128/aac.00002-08
Vibrio parahaemolyticus Vibrio parahaemolyticus Activity 100.0 % 10.1128/aac.00002-08
Vibrio vulnificus Vibrio vulnificus Activity 0.0 % 10.1128/aac.00002-08
Vibrio vulnificus Vibrio vulnificus Activity 100.0 % 10.1128/aac.00002-08
None ADMET Activity 53.48 % 10.1128/aac.01051-10
None ADMET Activity 57.03 % 10.1128/aac.01051-10
None ADMET AUC 4.7 ng.hr.mL-1 10.1016/j.bmc.2016.07.029
None ADMET AUC 1650.0 ng.hr.mL-1 10.1128/aac.00065-07
None ADMET AUC 2520.0 ng.hr.mL-1 10.1128/aac.01051-10
None ADMET AUC 2600.0 ng.hr.mL-1 10.1128/aac.01051-10
None ADMET AUC 4300.0 ng.hr.mL-1 10.1128/aac.00065-07
None ADMET AUC 5190.0 ng.hr.mL-1 10.1128/aac.00065-07
None ADMET AUC 6440.0 ng.hr.mL-1 10.1128/aac.00065-07
None ADMET AUC 9030.0 ng.hr.mL-1 10.1128/aac.00065-07
None ADMET AUC 11000.0 ng.hr.mL-1 10.1128/aac.00985-09
None ADMET AUC 15600.0 ng.hr.mL-1 10.1128/aac.00065-07
None ADMET AUC 20400.0 ng.hr.mL-1 10.1128/aac.00985-09
None ADMET AUC 22300.0 ng.hr.mL-1 10.1128/aac.00065-07
None ADMET AUC 30400.0 ng.hr.mL-1 10.1128/aac.00065-07
None ADMET AUC 32400.0 ng.hr.mL-1 10.1128/aac.00065-07
None ADMET AUC 41900.0 ng.hr.mL-1 10.1128/aac.00985-09
None ADMET AUC 3367000.0 ng.hr.mL-1 10.1128/aac.00065-07
None ADMET CL 3.8 mL.min-1.kg-1 10.1124/dmd.108.020479
None ADMET CL 23.8 L/hr 10.1016/j.bmc.2016.07.029
None ADMET Cmax 273.2 nM 10.1128/aac.01051-10
None ADMET Cmax 307.35 nM 10.1128/aac.01051-10
None ADMET Cmax 1485.5 nM 10.1016/j.bmc.2016.07.029
None ADMET Drug uptake 0.33 ug ml-1 10.1128/aac.01612-08
None ADMET Drug uptake 0.39 ug ml-1 10.1128/aac.01612-08
None ADMET Drug uptake 74.0 % 10.1128/aac.01051-10
None ADMET Drug uptake 98.94 % 10.1128/aac.01051-10
None ADMET Drug uptake 100.0 % 10.1128/aac.01051-10
None ADMET MRT 53.0 hr 10.1124/dmd.108.020479
None ADMET Ratio 0.16 None 10.1128/aac.00065-07
None ADMET Ratio 0.561 None 10.1128/aac.00065-07
None ADMET Ratio 0.683 None 10.1128/aac.00065-07
None ADMET Ratio 0.823 None 10.1128/aac.00065-07
None ADMET Ratio 1.15 None 10.1128/aac.00065-07
None ADMET Ratio 1.73 None 10.1128/aac.00065-07
None ADMET Ratio 2.45 None 10.1128/aac.00065-07
None ADMET Ratio 3.91 None 10.1128/aac.00065-07
None ADMET Ratio 5.23 None 10.1128/aac.00065-07
None ADMET Ratio 7.02 None 10.1128/aac.00985-09
None ADMET Ratio 8.6 None 10.1128/aac.00979-08
None ADMET Ratio 15.11 None 10.1128/aac.00985-09
None ADMET Ratio 23.95 None 10.1128/aac.00985-09
None ADMET Ratio 199.0 None 10.1128/aac.00065-07
None ADMET Ratio AUC 78.0 None 10.1128/aac.00979-08
None ADMET RatioAUC/MIC 13.3 None 10.1128/aac.01084-06
None ADMET RatioAUC/MIC 32.5 None 10.1128/aac.01084-06
None ADMET T1/2 15.96 hr 10.1128/aac.01051-10
None ADMET T1/2 24.88 hr 10.1128/aac.01051-10
None ADMET T1/2 37.0 hr 10.1016/j.bmc.2016.07.029
None ADMET T1/2 48.0 hr 10.1124/dmd.108.020479
None ADMET Tmax 3.38 hr 10.1128/aac.01051-10
None ADMET Tmax 4.38 hr 10.1128/aac.01051-10
None ADMET Vd 35.2 l 10.1128/aac.00065-07
None ADMET Vd 50.5 l 10.1128/aac.00065-07
None ADMET Vdss 12.0 L.kg-1 10.1124/dmd.108.020479
None Hepatotoxicity HepSE_bilirubinemia 1.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_cholecystitis 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_cholelithiasis 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_cirrhosis 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_Combined Scores 4.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_elevated liver function tests 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_hepatic failure 1.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_hepatic necrosis 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_hepatitis 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_hepatomegaly 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_jaundice 1.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_liver disease 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_liver fatty 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_liver function tests abnormal 1.0 None 10.1371/journal.pcbi.1002310
None Molecular identity unknown Inhibition nan % 10.1128/aac.00788-09
None Molecular identity unknown PPB 69.0 % 10.1016/j.bmc.2016.07.029
None NON-PROTEIN TARGET Activity 0.0 % 10.1128/aac.00002-08
None NON-PROTEIN TARGET Activity 0.0 % 10.1128/aac.00898-09
None NON-PROTEIN TARGET Activity 0.5 ug ml-1 10.1128/aac.00898-09
None NON-PROTEIN TARGET Activity 1.6 % 10.1128/aac.00002-08
None NON-PROTEIN TARGET Activity 7.2 % 10.1128/aac.01435-06
None NON-PROTEIN TARGET Activity 10.5 % 10.1128/aac.00081-08
None NON-PROTEIN TARGET Activity 98.4 % 10.1128/aac.00002-08
None NON-PROTEIN TARGET Activity 100.0 % 10.1128/aac.00002-08
None NON-PROTEIN TARGET fAUC/MIC 0.5 None 10.1128/aac.00647-08
None NON-PROTEIN TARGET fAUC/MIC 0.6 None 10.1128/aac.00647-08
None NON-PROTEIN TARGET fAUC/MIC 0.877 None 10.1128/aac.00647-08
None NON-PROTEIN TARGET fAUC/MIC 0.954 None 10.1128/aac.00647-08
None NON-PROTEIN TARGET fAUC/MIC 0.957 None 10.1128/aac.00647-08
None NON-PROTEIN TARGET fAUC/MIC 0.966 None 10.1128/aac.00647-08
None NON-PROTEIN TARGET fAUC/MIC 0.97 None 10.1128/aac.00647-08
None NON-PROTEIN TARGET fAUC/MIC 0.983 None 10.1128/aac.00647-08
None NON-PROTEIN TARGET fAUC/MIC 0.997 None 10.1128/aac.00647-08
None NON-PROTEIN TARGET fAUC/MIC 1.5 None 10.1128/aac.00647-08
None NON-PROTEIN TARGET fAUC/MIC 1.6 None 10.1128/aac.00647-08
None NON-PROTEIN TARGET fAUC/MIC 1.7 None 10.1128/aac.00647-08
None NON-PROTEIN TARGET fAUC/MIC 1.8 None 10.1128/aac.00647-08
None NON-PROTEIN TARGET fAUC/MIC 2.2 None 10.1128/aac.00647-08
None NON-PROTEIN TARGET fAUC/MIC 2.5 None 10.1128/aac.00647-08
None NON-PROTEIN TARGET fAUC/MIC 2.6 None 10.1128/aac.00647-08
None NON-PROTEIN TARGET fAUC/MIC 2.8 None 10.1128/aac.00647-08
None NON-PROTEIN TARGET fAUC/MIC 3.2 None 10.1128/aac.00647-08
None NON-PROTEIN TARGET fAUC/MIC 3.5 None 10.1128/aac.00647-08
None NON-PROTEIN TARGET fAUC/MIC 3.6 None 10.1128/aac.00647-08
None NON-PROTEIN TARGET fAUC/MIC 4.1 None 10.1128/aac.00647-08
None NON-PROTEIN TARGET fAUC/MIC 4.2 None 10.1128/aac.00647-08
None NON-PROTEIN TARGET fAUC/MIC 5.0 None 10.1128/aac.00647-08
None NON-PROTEIN TARGET fAUC/MIC 5.1 None 10.1128/aac.00647-08
None NON-PROTEIN TARGET fAUC/MIC 5.3 None 10.1128/aac.00647-08
None NON-PROTEIN TARGET fAUC/MIC 5.7 None 10.1128/aac.01051-10
None NON-PROTEIN TARGET fAUC/MIC 7.0 None 10.1128/aac.00647-08
None NON-PROTEIN TARGET fAUC/MIC 7.2 None 10.1128/aac.00647-08
None NON-PROTEIN TARGET fAUC/MIC 8.8 None 10.1128/aac.00647-08
None NON-PROTEIN TARGET fAUC/MIC 13.0 None 10.1128/aac.00647-08
None NON-PROTEIN TARGET fCmax/MIC 0.508 None 10.1128/aac.00647-08
None NON-PROTEIN TARGET fCmax/MIC 0.704 None 10.1128/aac.00647-08
None NON-PROTEIN TARGET fCmax/MIC 0.77 None 10.1128/aac.00647-08
None NON-PROTEIN TARGET fCmax/MIC 0.88 None 10.1128/aac.00647-08
None NON-PROTEIN TARGET fCmax/MIC 0.892 None 10.1128/aac.00647-08
None NON-PROTEIN TARGET fCmax/MIC 0.953 None 10.1128/aac.00647-08
None NON-PROTEIN TARGET fCmax/MIC 0.974 None 10.1128/aac.00647-08
None NON-PROTEIN TARGET fT>MIC 0.341 % 10.1128/aac.00647-08
None NON-PROTEIN TARGET fT>MIC 0.483 % 10.1128/aac.00647-08
None NON-PROTEIN TARGET fT>MIC 0.511 % 10.1128/aac.00647-08
None NON-PROTEIN TARGET fT>MIC 0.552 % 10.1128/aac.00647-08
None NON-PROTEIN TARGET fT>MIC 0.699 % 10.1128/aac.00647-08
None NON-PROTEIN TARGET fT>MIC 0.872 % 10.1128/aac.00647-08
None NON-PROTEIN TARGET fT>MIC 0.894 % 10.1128/aac.00647-08
None NON-PROTEIN TARGET fT>MIC 50.0 % 10.1128/aac.00922-07
None NON-PROTEIN TARGET Fu 0.2 None 10.1124/dmd.108.020479
None NON-PROTEIN TARGET MBC 0.095 mg/ml 10.1128/aac.00788-09
None NON-PROTEIN TARGET MBC 0.195 mg/ml 10.1128/aac.00788-09
None NON-PROTEIN TARGET MIC 6e-05 ug.mL-1 10.1128/aac.01102-06
None NON-PROTEIN TARGET MIC 0.00012 ug.mL-1 10.1128/aac.01102-06
None NON-PROTEIN TARGET MIC 0.00025 ug.mL-1 10.1128/aac.01102-06
None NON-PROTEIN TARGET MIC 0.015 ug.mL-1 10.1128/aac.01129-07
None NON-PROTEIN TARGET MIC 0.03 ug.mL-1 10.1128/aac.00695-08
None NON-PROTEIN TARGET MIC 0.06 ug.mL-1 10.1128/aac.00695-08
None NON-PROTEIN TARGET MIC 0.06 ug.mL-1 10.1128/aac.01084-06
None NON-PROTEIN TARGET MIC 0.12 ug.mL-1 10.1128/aac.00695-08
None NON-PROTEIN TARGET MIC 0.125 ug.mL-1 10.1128/aac.00081-08
None NON-PROTEIN TARGET MIC 0.25 ug.mL-1 10.1128/aac.00899-09
None NON-PROTEIN TARGET MIC 0.5 ug.mL-1 10.1128/aac.00899-09
None NON-PROTEIN TARGET MIC 1.0 ug.mL-1 10.1128/aac.00899-09
None NON-PROTEIN TARGET MIC 1.51 ug.mL-1 10.1128/aac.01435-06
None NON-PROTEIN TARGET MIC 2.0 ug.mL-1 10.1128/aac.00899-09
None NON-PROTEIN TARGET MIC 2.0 ug.mL-1 10.1128/aac.00993-09
None NON-PROTEIN TARGET MIC 6.0 ug.mL-1 10.1128/aac.00788-09
None NON-PROTEIN TARGET MIC 16.0 ug.mL-1 10.1128/aac.00993-09
None NON-PROTEIN TARGET MIC50 0.008 ug.mL-1 10.1128/aac.00898-09
None NON-PROTEIN TARGET MIC50 0.015 ug.mL-1 10.1128/aac.01129-07
None NON-PROTEIN TARGET MIC50 1.0 ug.mL-1 10.1128/aac.00081-08
None NON-PROTEIN TARGET MIC50 1.0 ug.mL-1 10.1128/aac.00858-06
None NON-PROTEIN TARGET MIC50 2.0 ug.mL-1 10.1128/aac.00572-10
None NON-PROTEIN TARGET MIC50 2.0 ug.mL-1 10.1128/aac.00858-06
None NON-PROTEIN TARGET MIC90 0.015 ug.mL-1 10.1128/aac.01129-07
None NON-PROTEIN TARGET MIC90 0.023 ug.mL-1 10.1128/aac.00898-09
None NON-PROTEIN TARGET MIC90 0.032 ug.mL-1 10.1128/aac.00898-09
None NON-PROTEIN TARGET MIC90 2.0 ug.mL-1 10.1128/aac.00858-06
None NON-PROTEIN TARGET MIC90 8.0 ug.mL-1 10.1128/aac.00081-08
None NON-PROTEIN TARGET MIC90 8.0 ug.mL-1 10.1128/aac.00858-06
None NON-PROTEIN TARGET MIC90 8.0 ug.mL-1 10.1128/aac.01435-06
None NON-PROTEIN TARGET RatioAUC/MIC 21.0 None 10.1128/aac.01051-10
None NON-PROTEIN TARGET RatioAUC/MIC 22.1 None 10.1128/aac.01051-10
None Unchecked Activity 31.0 % 10.1128/aac.01198-06
None Unchecked Activity 52.0 % 10.1128/aac.01198-06
None Unchecked Activity 114.0 % 10.1128/aac.01198-06
None Unchecked Activity 115.0 % 10.1128/aac.01198-06
None Unchecked Activity 206.0 % 10.1128/aac.01198-06
None Unchecked fAUC/MIC 0.38 None 10.1128/aac.00985-09
None Unchecked fAUC/MIC 0.41 None 10.1128/aac.00985-09
None Unchecked fAUC/MIC 0.43 None 10.1128/aac.00985-09
None Unchecked fAUC/MIC 0.69 None 10.1128/aac.00985-09
None Unchecked fAUC/MIC 1.43 None 10.1128/aac.00985-09
None Unchecked fAUC/MIC 1.51 None 10.1128/aac.00985-09
None Unchecked fAUC/MIC 2.01 None 10.1128/aac.01678-08
None Unchecked fAUC/MIC 2.02 None 10.1128/aac.01678-08
None Unchecked fAUC/MIC 2.11 None 10.1128/aac.00985-09
None Unchecked fAUC/MIC 2.17 None 10.1128/aac.00985-09
None Unchecked fAUC/MIC 2.29 None 10.1128/aac.00985-09
None Unchecked fAUC/MIC 2.33 None 10.1128/aac.00985-09
None Unchecked fAUC/MIC 2.38 None 10.1128/aac.00985-09
None Unchecked fAUC/MIC 2.48 None 10.1128/aac.00985-09
None Unchecked fAUC/MIC 2.64 None 10.1128/aac.00985-09
None Unchecked fAUC/MIC 2.64 None 10.1128/aac.01678-08
None Unchecked fAUC/MIC 2.68 None 10.1128/aac.00985-09
None Unchecked fAUC/MIC 3.09 None 10.1128/aac.01678-08
None Unchecked fAUC/MIC 3.12 None 10.1128/aac.00985-09
None Unchecked fAUC/MIC 3.27 None 10.1128/aac.01678-08
None Unchecked fAUC/MIC 3.62 None 10.1128/aac.01678-08
None Unchecked fAUC/MIC 3.7 None 10.1128/aac.01678-08
None Unchecked fAUC/MIC 3.71 None 10.1128/aac.01678-08
None Unchecked fAUC/MIC 3.88 None 10.1128/aac.01678-08
None Unchecked fAUC/MIC 3.91 None 10.1128/aac.00985-09
None Unchecked fAUC/MIC 4.18 None 10.1128/aac.00985-09
None Unchecked fAUC/MIC 4.46 None 10.1128/aac.01678-08
None Unchecked fAUC/MIC 4.53 None 10.1128/aac.01678-08
None Unchecked fAUC/MIC 4.76 None 10.1128/aac.01678-08
None Unchecked fAUC/MIC 4.81 None 10.1128/aac.01678-08
None Unchecked fAUC/MIC 5.13 None 10.1128/aac.01678-08
None Unchecked fAUC/MIC 5.19 None 10.1128/aac.01678-08
None Unchecked fAUC/MIC 5.22 None 10.1128/aac.00985-09
None Unchecked fAUC/MIC 5.37 None 10.1128/aac.01678-08
None Unchecked fAUC/MIC 5.4 None 10.1128/aac.01678-08
None Unchecked fAUC/MIC 5.47 None 10.1128/aac.01678-08
None Unchecked fAUC/MIC 5.91 None 10.1128/aac.01678-08
None Unchecked fAUC/MIC 5.96 None 10.1128/aac.01678-08
None Unchecked fAUC/MIC 6.27 None 10.1128/aac.01678-08
None Unchecked fAUC/MIC 6.4 None 10.1128/aac.01678-08
None Unchecked fAUC/MIC 6.53 None 10.1128/aac.01678-08
None Unchecked fAUC/MIC 6.83 None 10.1128/aac.01678-08
None Unchecked fAUC/MIC 7.15 None 10.1128/aac.01678-08
None Unchecked fAUC/MIC 7.3 None 10.1128/aac.01678-08
None Unchecked fAUC/MIC 7.48 None 10.1128/aac.01678-08
None Unchecked fAUC/MIC 7.5 None 10.1128/aac.01678-08
None Unchecked fAUC/MIC 7.7 None 10.1128/aac.01678-08
None Unchecked fAUC/MIC 7.78 None 10.1128/aac.01678-08
None Unchecked fAUC/MIC 9.07 None 10.1128/aac.01678-08
None Unchecked fAUC/MIC 10.04 None 10.1128/aac.01678-08
None Unchecked fAUC/MIC 10.64 None 10.1128/aac.01678-08
None Unchecked MIC 0.06 ug.mL-1 10.1016/j.bmc.2020.115776
None Unchecked Ratio 21.8 None 10.1128/aac.00182-09
None Unchecked RatioAUC/MIC 17.9 None 10.1128/aac.01051-10
None Unchecked RatioAUC/MIC 21.7 None 10.1128/aac.01051-10
None Unchecked RatioAUC/MIC 33.25 None 10.1128/aac.01051-10

Metabolism Information

AKRT ID Reaction Reaction Link ID
AKRT010413 CN(C)c1cc(NC(=O)CNC(C)(C)C)c(O)c2c1C[C@H]1C[C@H]3[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]3(O)C(O)=C1C2=O>>CN(C)c1cc(NC(=O)CNC(C)(C)C)c(O)c2c1C[C@H]1C[C@H]3[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]3(O)C(=O)[C@@]1(O)C2=O RXN-17969