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name Structure Reference Source Properties Activities Metabolism

Corypalmine

AlkaPlorer ID: AK018426

Synonym: 'Tetrahydrojatrorrhizine', 'Corypalmine', '(-)-Corypalmine'

IUPAC Name: (13aS)-2,9,10-trimethoxy-6,8,13,13a-tetrahydro-5H-isoquinolino[2,1-b]isoquinolin-3-ol

Structure

SMILES: COC1=CC2=C(C=C1O)CCN1CC3=C(C=CC(OC)=C3OC)C[C@@H]21

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InChI: InChI=1S/C20H23NO4/c1-23-18-5-4-12-8-16-14-10-19(24-2)17(22)9-13(14)6-7-21(16)11-15(12)20(18)25-3/h4-5,9-10,16,22H,6-8,11H2,1-3H3/t16-/m0/s1

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InChIKey: BMCZTYDZHNTKPR-INIZCTEOSA-N

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Source

Species Genus Family Order Class Phylum Kingdom Domain
Fibraurea recisa Fibraurea Menispermaceae Ranunculales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Photinus marginellus Photinus Lampyridae Coleoptera Insecta Arthropoda Metazoa Eukaryota
Sideritis ferrensis Sideritis Lamiaceae Lamiales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Corydalis yanhusuo Corydalis Papaveraceae Ranunculales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Grevillea hilliana Grevillea Proteaceae Proteales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Erythrophleum suaveolens Erythrophleum Fabaceae Fabales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Aglaia spectabilis Aglaia Meliaceae Sapindales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Piper retrofractum Piper Piperaceae Piperales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Cyclacanthia bellae Cyclacanthia Latrunculiidae Poecilosclerida Demospongiae Porifera Metazoa Eukaryota
Horsfieldia glabra Horsfieldia Myristicaceae Magnoliales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Radula voluta Radula Radulaceae Porellales Jungermanniopsida Streptophyta Viridiplantae Eukaryota
Dendrobium amplum Dendrobium Orchidaceae Asparagales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Dalbergia spruceana Dalbergia Fabaceae Fabales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Corydalis ternata Corydalis Papaveraceae Ranunculales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Cyperus nipponicus Cyperus Cyperaceae Poales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Micromelum ceylanicum Micromelum Rutaceae Sapindales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Lactarius chrysorrheus Lactarius Russulaceae Russulales Agaricomycetes Basidiomycota Fungi Eukaryota
Corydalis turtschaninovii Corydalis Papaveraceae Ranunculales Magnoliopsida Streptophyta Viridiplantae Eukaryota

Properties Information

Molecule Weight: 341.4070000000001

TPSA？: 51.16000000000001

MolLogP？: 3.073500000000002

Number of H-Donors: 1

Number of H-Acceptors: 5

RingCount: 4

Activities Information

Organism Target Name Standard Type Standard Value Standard Units doi
Homo sapiens Dopamine D1 receptor Inhibition 84.1 % 10.1016/j.bmc.2012.12.016
Homo sapiens Dopamine D1 receptor Ki 199.0 nM 10.1016/j.bmcl.2017.01.090
Homo sapiens Dopamine D1 receptor Ki 310.0 nM 10.1016/j.bmc.2012.12.016
Homo sapiens Dopamine D2 receptor Inhibition 63.2 % 10.1016/j.bmc.2012.12.016
Homo sapiens Dopamine D2 receptor Ki 42.4 nM 10.1016/j.bmcl.2017.01.090
Homo sapiens Dopamine D2 receptor Ki nan None 10.1016/j.bmc.2012.12.016
Homo sapiens Dopamine D3 receptor Ki 262.0 nM 10.1016/j.bmcl.2017.01.090
Homo sapiens Dopamine D4 receptor Ki 1000.0 nM 10.1016/j.bmcl.2017.01.090
Homo sapiens Dopamine D5 receptor Ki 313.0 nM 10.1016/j.bmcl.2017.01.090
Homo sapiens Serotonin 1a (5-HT1a) receptor Inhibition 50.5 % 10.1016/j.bmc.2012.12.016
Homo sapiens Serotonin 1a (5-HT1a) receptor Ki nan None 10.1016/j.bmc.2012.12.016
Homo sapiens Serotonin 2a (5-HT2a) receptor Inhibition 38.0 % 10.1016/j.bmc.2012.12.016
Homo sapiens Serotonin 2a (5-HT2a) receptor Ki nan None 10.1016/j.bmc.2012.12.016

Metabolism Information