2-Aminophenol; N-Ac
AlkaPlorer ID: AK019063
Synonym: 2-Acetamidophenol, 2-Hydroxyacetanilide, N-(2-Hydroxyphenyl)acetamide
IUPAC Name: N-(2-hydroxyphenyl)acetamide
Structure
SMILES: CC(O)=NC1=CC=CC=C1O
InChI: InChI=1S/C8H9NO2/c1-6(10)9-7-4-2-3-5-8(7)11/h2-5,11H,1H3,(H,9,10)
InChIKey: ADVGKWPZRIDURE-UHFFFAOYSA-N
Reference
α-Glucosidase inhibitors and phytotoxins from <i>Streptomyces xanthophaeus</i>
PubChem CID: 11972
CAS: 614-80-2
LOTUS: LTS0237119
SuperNatural Ⅲ: SN0002948
NPASS: NPC490883
COCONUT: CNP0144383
data_source: manually
Source
| Species | Genus | Family | Order | Class | Phylum | Kingdom | Domain |
|---|---|---|---|---|---|---|---|
| Actinokineospora sp. | Actinokineospora | Pseudonocardiaceae | Pseudonocardiales | Actinomycetes | Actinomycetota | None | Bacteria |
| Homo sapiens | Homo | Hominidae | Primates | Mammalia | Chordata | Metazoa | Eukaryota |
| Nocardiopsis sp. RV163 | Nocardiopsis | Nocardiopsaceae | Streptosporangiales | Actinomycetes | Actinomycetota | None | Bacteria |
Properties Information
Molecule Weight: 151.16499999999996
TPSA？: 52.82000000000001
MolLogP？: 2.0001
Number of H-Donors: 2
Number of H-Acceptors: 2
RingCount: 1
Activities Information
| Organism | Target Name | Standard Type | Standard Value | Standard Units | doi |
|---|---|---|---|---|---|
| Escherichia coli K-12 | Beta-lactamase AmpC | Potency | 44668.4 | nM | None |
| Homo sapiens | Bromodomain adjacent to zinc finger domain protein 2B | Potency | 100000.0 | nM | None |
| Homo sapiens | Cholesterol 24-hydroxylase | Activity | 103.0 | % | None |
| Homo sapiens | DNA-(apurinic or apyrimidinic site) lyase | Potency | 44668.4 | nM | None |
| Mus musculus | RAW264.7 | GI50 | 4204000.0 | nM | 10.1039/C3MD00251A |
| Mycobacterium tuberculosis | Mycobacterium tuberculosis | MIC | 132000.0 | nM | 10.1039/C3MD00251A |
| Mycobacterium tuberculosis variant bovis BCG | Mycobacterium tuberculosis variant bovis BCG | MIC | 132000.0 | nM | 10.1039/C3MD00251A |
| Mycolicibacterium smegmatis | Mycolicibacterium smegmatis | MIC | 600000.0 | nM | 10.1039/C3MD00251A |
| Simian virus 40 | Large T antigen | IC50 | 6200.0 | nM | None |
| None | Unchecked | AC50 | 18440.0 | nM | None |
| None | Unchecked | IC50 | 2630.0 | nM | None |
| None | Unchecked | Potency | 31622.8 | nM | None |
| None | Unchecked | Selectivity Index | 31.8 | None | 10.1039/C3MD00251A |