holomycin
AlkaPlorer ID: AK019459
Synonym: None
IUPAC Name: N-(5-oxo-4H-dithiolo[4,3-b]pyrrol-6-yl)acetamide
Structure
SMILES: CC(O)=NC1=C2SSC=C2N=C1O
InChI: InChI=1S/C7H6N2O2S2/c1-3(10)8-5-6-4(2-12-13-6)9-7(5)11/h2H,1H3,(H,8,10)(H,9,11)
InChIKey: HBUNPJGMNVQSBX-UHFFFAOYSA-N
Reference
PubChem CID: 10262683
CAS: 488-04-0
LOTUS: LTS0212036
NPASS: NPC314800
COCONUT: CNP0213632
{NPAtlas: NPA013565
Source
| Species | Genus | Family | Order | Class | Phylum | Kingdom | Domain |
|---|---|---|---|---|---|---|---|
| Streptomyces sp. | Streptomyces | Streptomycetaceae | Kitasatosporales | Actinomycetes | Actinomycetota | None | Bacteria |
Properties Information
Molecule Weight: 214.271
TPSA？: 65.71000000000001
MolLogP？: 2.6229
Number of H-Donors: 2
Number of H-Acceptors: 5
RingCount: 2
Activities Information
| Organism | Target Name | Standard Type | Standard Value | Standard Units | doi |
|---|---|---|---|---|---|
| Staphylococcus epidermidis | Staphylococcus epidermidis | Activity | nan | None | 10.1128/aac.00343-07 |
| Staphylococcus epidermidis | Staphylococcus epidermidis | MBC | 50.0 | ug ml-1 | 10.1128/aac.00343-07 |
| Staphylococcus epidermidis | Staphylococcus epidermidis | MIC | 12.5 | ug.mL-1 | 10.1128/aac.00343-07 |
| Staphylococcus epidermidis | Staphylococcus epidermidis | Ratio | 4.0 | None | 10.1128/aac.00343-07 |
| None | Unchecked | IC50 | 100.0 | ug.mL-1 | 10.1128/aac.00343-07 |