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Kenidine

AlkaPlorer ID: AK019487

Synonym: 'Kenidine', 'Kenigicine', 'Koenidine', 'Kenimbidine', 'Koenimbidine'

IUPAC Name: 8,9-dimethoxy-3,3,5-trimethyl-11H-pyrano[3,2-a]carbazole

Structure

SMILES: COC1=CC2=C(C=C1OC)C1=CC(C)=C3OC(C)(C)C=CC3=C1N2

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InChI: InChI=1S/C20H21NO3/c1-11-8-14-13-9-16(22-4)17(23-5)10-15(13)21-18(14)12-6-7-20(2,3)24-19(11)12/h6-10,21H,1-5H3

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InChIKey: IUZVYLWUISSZCS-UHFFFAOYSA-N

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Source

Species Genus Family Order Class Phylum Kingdom Domain
Murraya koenigii Murraya Rutaceae Sapindales Magnoliopsida Streptophyta Viridiplantae Eukaryota

Properties Information

Molecule Weight: 323.392

TPSA？: 43.48

MolLogP？: 4.830920000000003

Number of H-Donors: 1

Number of H-Acceptors: 3

RingCount: 4

Activities Information

Organism Target Name Standard Type Standard Value Standard Units doi
Homo sapiens Pancreatic lipase IC50 428600.0 nM 10.1016/j.bmc.2016.11.031
Mus musculus Mus musculus Activity 44.3 % 10.1021/acs.jnatprod.5b00883
Mus musculus Mus musculus Inhibition 17.2 % 10.1021/acs.jnatprod.5b00883
None ADMET AUC 7447.67 ng.hr.mL-1 10.1021/acs.jnatprod.5b00883
None ADMET Cmax 2820.0 nM 10.1021/acs.jnatprod.5b00883
None ADMET K 0.003 /min 10.1021/acs.jnatprod.5b00883
None ADMET Stability 79.0 % 10.1021/acs.jnatprod.5b00883
None ADMET T1/2 3.108 hr 10.1021/acs.jnatprod.5b00883
None ADMET Tmax 4.0 hr 10.1021/acs.jnatprod.5b00883
None Molecular identity unknown Activity nan None 10.1021/acs.jnatprod.5b00883
None Molecular identity unknown FC 1.29 None 10.1021/acs.jnatprod.5b00883
None Molecular identity unknown FC 1.42 None 10.1021/acs.jnatprod.5b00883
None Molecular identity unknown FC 2.41 None 10.1021/acs.jnatprod.5b00883
None NON-PROTEIN TARGET Inhibition 21.8 % 10.1021/acs.jnatprod.5b00883
None NON-PROTEIN TARGET Inhibition 22.5 % 10.1021/acs.jnatprod.5b00883
None NON-PROTEIN TARGET Inhibition 28.5 % 10.1021/acs.jnatprod.5b00883
None NON-PROTEIN TARGET Inhibition 30.0 % 10.1021/acs.jnatprod.5b00883
None NON-PROTEIN TARGET Inhibition 40.5 % 10.1021/acs.jnatprod.5b00883
None NON-PROTEIN TARGET Inhibition nan % 10.1021/acs.jnatprod.5b00883
None Unchecked Activity nan None 10.1021/acs.jnatprod.5b00883

Metabolism Information