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veprisine

AlkaPlorer ID: AK019490

Synonym: '7,8-Dimethoxy-N-methylflindersine', 'Veprisine', 'NSC 363785', 'ConMedNP.1126'

IUPAC Name: 7,8-dimethoxy-2,2,6-trimethylpyrano[3,2-c]quinolin-5-one

Structure

SMILES: COC1=CC=C2C3=C(C=CC(C)(C)O3)C(=O)N(C)C2=C1OC

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InChI: InChI=1S/C17H19NO4/c1-17(2)9-8-11-14(22-17)10-6-7-12(20-4)15(21-5)13(10)18(3)16(11)19/h6-9H,1-5H3

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InChIKey: DWZSQRJGZJNUEK-UHFFFAOYSA-N

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Source

Species Genus Family Order Class Phylum Kingdom Domain
Vepris stolzii Vepris Rutaceae Sapindales Magnoliopsida Streptophyta Viridiplantae Eukaryota

Properties Information

Molecule Weight: 301.34200000000004

TPSA？: 49.69

MolLogP？: 2.7399000000000004

Number of H-Donors: 0

Number of H-Acceptors: 5

RingCount: 3

Activities Information

Organism Target Name Standard Type Standard Value Standard Units doi
Homo sapiens 786-0 GI50 43052.66 nM None
Homo sapiens A498 GI50 17947.34 nM None
Homo sapiens A549 GI50 44668.36 nM None
Homo sapiens ACHN GI50 13708.82 nM None
Homo sapiens BT-549 GI50 22080.05 nM None
Homo sapiens CAKI-1 GI50 13520.73 nM None
Homo sapiens CCRF-CEM GI50 23173.95 nM None
Homo sapiens COLO 205 GI50 19724.23 nM None
Homo sapiens DU-145 GI50 43651.58 nM None
Homo sapiens EKVX GI50 23933.16 nM None
Homo sapiens HCC 2998 GI50 29512.09 nM None
Homo sapiens HCT-116 GI50 29853.83 nM None
Homo sapiens HCT-15 GI50 13365.96 nM None
Homo sapiens HL-60 GI50 11194.38 nM None
Homo sapiens HOP-62 GI50 80167.81 nM None
Homo sapiens HOP-92 GI50 17988.71 nM None
Homo sapiens Hs-578T GI50 23496.33 nM None
Homo sapiens HT-29 GI50 24043.63 nM None
Homo sapiens IGROV-1 GI50 36140.99 nM None
Homo sapiens KM12 GI50 21627.19 nM None
Homo sapiens LOX IMVI GI50 33651.16 nM None
Homo sapiens M14 GI50 48305.88 nM None
Homo sapiens Malme-3M GI50 50350.06 nM None
Homo sapiens MCF7 GI50 36812.9 nM None
Homo sapiens MDA-MB-231 GI50 21978.6 nM None
Homo sapiens MDA-MB-435 GI50 38282.47 nM None
Homo sapiens MDA-N GI50 21677.04 nM None
Homo sapiens MOLT-4 GI50 24434.31 nM None
Homo sapiens NCI/ADR-RES GI50 18030.18 nM None
Homo sapiens NCI-H226 GI50 22181.96 nM None
Homo sapiens NCI-H23 GI50 22803.42 nM None
Homo sapiens NCI-H322M GI50 89949.76 nM None
Homo sapiens NCI-H522 GI50 34514.37 nM None
Homo sapiens OVCAR-3 GI50 47973.34 nM None
Homo sapiens OVCAR-4 GI50 19142.56 nM None
Homo sapiens OVCAR-5 GI50 82035.15 nM None
Homo sapiens OVCAR-8 GI50 23933.16 nM None
Homo sapiens PC-3 GI50 33728.73 nM None
Homo sapiens RPMI-8226 GI50 10046.16 nM None
Homo sapiens RXF 393 GI50 26485.0 nM None
Homo sapiens SF-268 GI50 26791.68 nM None
Homo sapiens SF-295 GI50 36728.23 nM None
Homo sapiens SF-539 GI50 39174.19 nM None
Homo sapiens SK-MEL-2 GI50 42559.84 nM None
Homo sapiens SK-MEL-28 GI50 41879.36 nM None
Homo sapiens SK-MEL-5 GI50 13304.54 nM None
Homo sapiens SK-OV-3 GI50 32136.61 nM None
Homo sapiens SN12C GI50 12676.52 nM None
Homo sapiens SNB-19 GI50 20653.8 nM None
Homo sapiens SNB-75 GI50 2779.71 nM None
Homo sapiens SR GI50 3459.39 nM None
Homo sapiens SW-620 GI50 28379.19 nM None
Homo sapiens T47D GI50 25763.21 nM None
Homo sapiens TK-10 GI50 28773.98 nM None
Homo sapiens U-251 GI50 30619.63 nM None
Homo sapiens UACC-257 GI50 35318.32 nM None
Homo sapiens UACC-62 GI50 37844.26 nM None
Homo sapiens UO-31 GI50 20941.12 nM None
Mus musculus N1E-115 BK 55.0 % 10.1021/jm001007u
Mus musculus N1E-115 BNa 12.0 % 10.1021/jm001007u
Mus musculus Voltage-gated potassium channel subunit Kv1.3 BK 41.0 % 10.1021/jm001007u

Metabolism Information