Ancistrotanzanine A
AlkaPlorer ID: AK019546
Synonym: None
IUPAC Name: 2-[(3S)-6,8-dimethoxy-1,3-dimethyl-3,4-dihydroisoquinolin-5-yl]-8-methoxy-3-methylnaphthalen-1-ol
Structure
SMILES: COC1=CC(OC)=C(C2=C(C)C=C3C=CC=C(OC)C3=C2O)C2=C1C(C)=N[C@@H](C)C2
InChI: InChI=1S/C25H27NO4/c1-13-10-16-8-7-9-18(28-4)23(16)25(27)21(13)24-17-11-14(2)26-15(3)22(17)19(29-5)12-20(24)30-6/h7-10,12,14,27H,11H2,1-6H3/t14-/m0/s1
InChIKey: QGIHYQPVZRSTNP-AWEZNQCLSA-N
Source
| Species | Genus | Family | Order | Class | Phylum | Kingdom | Domain |
|---|---|---|---|---|---|---|---|
| Ancistrocladus tanzaniensis | Ancistrocladus | Ancistrocladaceae | Caryophyllales | Magnoliopsida | Streptophyta | Viridiplantae | Eukaryota |
Properties Information
Molecule Weight: 405.4940000000002
TPSA？: 60.28
MolLogP？: 5.300220000000006
Number of H-Donors: 1
Number of H-Acceptors: 5
RingCount: 4
Activities Information
| Organism | Target Name | Standard Type | Standard Value | Standard Units | doi |
|---|---|---|---|---|---|
| Leishmania donovani | Leishmania donovani | IC50 | 1.8 | ug.mL-1 | 10.1021/np030077b |
| Leishmania donovani | Leishmania donovani | IC50 | 1.8 | ug.mL-1 | 10.1021/np800472q |
| Plasmodium falciparum | Plasmodium falciparum | IC50 | 0.3 | ug.mL-1 | 10.1021/np030077b |
| Plasmodium falciparum | Plasmodium falciparum | IC50 | nan | None | 10.1021/np030077b |
| Rattus norvegicus | L6 | MIC | 6.4 | ug.mL-1 | 10.1021/np030077b |
| Trypanosoma brucei rhodesiense | Trypanosoma brucei rhodesiense | IC50 | 0.7 | ug.mL-1 | 10.1021/np030077b |
| Trypanosoma cruzi | Trypanosoma cruzi | IC50 | 1.7 | ug.mL-1 | 10.1021/np030077b |