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Ganciclovir

AlkaPlorer ID: AK019563

Synonym: None

IUPAC Name: 2-amino-9-(1,3-dihydroxypropan-2-yloxymethyl)-1H-purin-6-one

Structure

SMILES: N=C1N=C(O)C2=C(N1)N(COC(CO)CO)C=N2

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InChI: InChI=1S/C9H13N5O4/c10-9-12-7-6(8(17)13-9)11-3-14(7)4-18-5(1-15)2-16/h3,5,15-16H,1-2,4H2,(H3,10,12,13,17)

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InChIKey: IRSCQMHQWWYFCW-UHFFFAOYSA-N

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Source

Species Genus Family Order Class Phylum Kingdom Domain
Homo sapiens Homo Hominidae Primates Mammalia Chordata Metazoa Eukaryota

Properties Information

Molecule Weight: 255.234

TPSA？: 140.27

MolLogP？: -1.7282300000000006

Number of H-Donors: 5

Number of H-Acceptors: 8

RingCount: 2

Activities Information

Organism Target Name Standard Type Standard Value Standard Units doi
Acinetobacter baumannii Acinetobacter baumannii Inhibition 17.44 % 10.6019/CHEMBL4513141
Acinetobacter baumannii Acinetobacter baumannii MIC 20000.0 nM 10.6019/CHEMBL4513161
Anas sp. Anas sp. EC50 1.5 ug.mL-1 10.1021/jm010410d
Bacillus anthracis Bacillus anthracis IC50 nan None 10.1128/aac.01029-10
Bacillus subtilis (strain 168) ATP-dependent Clp protease proteolytic subunit Potency 707.9 nM None
Bos taurus Monoamine oxidase A Activity nan None 10.1021/jm800656v
Bos taurus Monoamine oxidase B Activity nan None 10.1021/jm800656v
Bos taurus Progesterone receptor IC50 nan None None
Bos taurus Progesterone receptor Ki nan None None
Candida albicans Candida albicans Inhibition 0.0 % 10.6019/CHEMBL4513141
Candida albicans Candida albicans MIC 20000.0 nM 10.6019/CHEMBL4513161
Canis lupus familiaris MDCK MCC nan None 10.1016/j.bmc.2015.12.008
Cavia porcellus Leukotriene C4 synthase IC50 nan None None
Cavia porcellus Leukotriene C4 synthase Ki nan None None
Cavia porcellus Serotonin 4 (5-HT4) receptor IC50 nan None None
Cavia porcellus Serotonin 4 (5-HT4) receptor Ki nan None None
Caviid betaherpesvirus 2 Caviid betaherpesvirus 2 EC50 25900.0 nM 10.1128/aac.00134-08
Chlorocebus sabaeus Vero CC50 100000.0 nM 10.1021/jm050162b
Chlorocebus sabaeus Vero CC50 666000.0 nM 10.1128/aac.01284-06
Chlorocebus sabaeus Vero CC50 nan None 10.1021/jm060102l
Chlorocebus sabaeus Vero CC50% 100.0 ug ml-1 10.1016/j.bmcl.2005.01.050
Chlorocebus sabaeus Vero CCID50 500.0 uM 10.1016/s0960-894x(01)00352-3
Chlorocebus sabaeus Vero CCID50 500.0 uM 10.1021/jm030810w
Chlorocebus sabaeus Vero Cytotoxicity 100.0 None 10.1021/jm991171l
Chlorocebus sabaeus Vero EC50 50000.0 nM 10.1021/jm040093l
Chlorocebus sabaeus Vero EC50 nan ug.mL-1 10.1016/s0960-894x(01)00589-3
Chlorocebus sabaeus Vero IC50 1.22 ug.mL-1 10.1016/j.bmcl.2005.01.050
Chlorocebus sabaeus Vero IC50 1.274 ug.mL-1 10.1016/j.bmcl.2005.01.050
Chlorocebus sabaeus Vero IC50 nan nM 10.1021/jm050162b
Chlorocebus sabaeus Vero IC50 nan ug.mL-1 10.1016/S0960-894X(01)80693-4
Chlorocebus sabaeus Vero ID50 0.2 uM 10.1021/jm00155a015
Chlorocebus sabaeus Vero ID50 0.2 uM 10.1021/jm00158a011
Chlorocebus sabaeus Vero ID50 0.2 uM 10.1021/jm00381a015
Chlorocebus sabaeus Vero ID50 1.6 uM 10.1021/jm00155a015
Chlorocebus sabaeus Vero ID50 10.0 uM 10.1021/jm00155a015
Chlorocebus sabaeus Vero ID50 100.0 ug ml-1 10.1021/jm00168a039
Chlorocebus sabaeus Vero ID50 125.0 uM 10.1021/jm00155a015
Chlorocebus sabaeus Vero ID50 450.0 uM 10.1021/jm00155a015
Chlorocebus sabaeus Vero ID50 500.0 uM 10.1021/jm00147a020
Chlorocebus sabaeus Vero MCC nan None 10.1016/j.bmc.2015.12.008
Chlorocebus sabaeus Vero MCC nan None 10.1021/jm050772b
Chlorocebus sabaeus Vero TC50 270.0 ug ml-1 10.1021/jm00020a009
Coxsackievirus Coxsackievirus EC50 nan nM 10.1021/jm0493966
Coxsackievirus B4 Coxsackievirus B4 Activity nan None 10.1016/j.ejmech.2011.11.021
Coxsackievirus B4 Coxsackievirus B4 MIC50 nan None 10.1021/jm050772b
Cryptococcus neoformans Cryptococcus neoformans Inhibition -0.42 % 10.6019/CHEMBL4513141
Cryptococcus neoformans Cryptococcus neoformans MIC 20000.0 nM 10.6019/CHEMBL4513161
Cytomegalovirus Cytomegalovirus EC50 0.24 ug.mL-1 10.1021/jm040869i
Cytomegalovirus Cytomegalovirus EC50 0.34 ug.mL-1 10.1021/jm040869i
Cytomegalovirus Cytomegalovirus EC50 0.37 ug.mL-1 10.1021/jm040878r
Cytomegalovirus Cytomegalovirus EC50 0.62 ug.mL-1 10.1016/s0960-894x(01)00270-0
Cytomegalovirus Cytomegalovirus EC50 0.77 ug.mL-1 10.1016/s0960-894x(01)00270-0
Cytomegalovirus Cytomegalovirus EC50 1.7 ug.mL-1 10.1016/j.ejmech.2009.02.030
Cytomegalovirus Cytomegalovirus EC50 2.6 nM 10.1016/j.ejmech.2021.113193
Cytomegalovirus Cytomegalovirus EC50 3.2 ug.mL-1 10.1021/jm051023x
Cytomegalovirus Cytomegalovirus EC50 7.5 ug.mL-1 10.1016/s0960-894x(01)00270-0
Cytomegalovirus Cytomegalovirus EC50 10.8 ug.mL-1 10.1016/s0960-894x(01)00270-0
Cytomegalovirus Cytomegalovirus EC50 250.0 nM 10.1016/j.ejmech.2016.04.034
Cytomegalovirus Cytomegalovirus EC50 380.0 nM 10.1016/j.ejmech.2013.06.036
Cytomegalovirus Cytomegalovirus EC50 400.0 nM 10.1016/j.ejmech.2016.04.034
Cytomegalovirus Cytomegalovirus EC50 1000.0 nM 10.1021/acs.jmedchem.2c00203
Cytomegalovirus Cytomegalovirus EC50 2300.0 nM 10.1016/j.ejmech.2019.111739
Cytomegalovirus Cytomegalovirus EC50 2600.0 nM 10.1016/j.ejmech.2018.03.076
Cytomegalovirus Cytomegalovirus EC50 2700.0 nM 10.1016/j.bmc.2013.04.027
Cytomegalovirus Cytomegalovirus EC50 3100.0 nM 10.1016/j.ejmech.2013.06.036
Cytomegalovirus Cytomegalovirus EC50 3150.0 nM 10.1016/j.ejmech.2019.111739
Cytomegalovirus Cytomegalovirus EC50 4440.0 nM 10.1021/acsmedchemlett.0c00090
Cytomegalovirus Cytomegalovirus EC50 5980.0 nM 10.1016/j.ejmech.2013.05.046
Cytomegalovirus Cytomegalovirus EC50 6300.0 nM 10.1016/j.bmc.2015.04.079
Cytomegalovirus Cytomegalovirus EC50 6500.0 nM 10.1016/j.ejmech.2016.10.002
Cytomegalovirus Cytomegalovirus EC50 7100.0 nM 10.1016/j.bmc.2015.04.079
Cytomegalovirus Cytomegalovirus EC50 7870.0 nM 10.1016/j.ejmech.2013.05.046
Cytomegalovirus Cytomegalovirus EC50 13000.0 nM 10.1021/acsmedchemlett.0c00090
Cytomegalovirus Cytomegalovirus EC50 14900.0 nM 10.1016/j.ejmech.2016.10.002
Cytomegalovirus Cytomegalovirus IC50 0.5 ug.mL-1 10.1021/jm981051y
Cytomegalovirus Cytomegalovirus IC50 0.6 ug.mL-1 10.1016/s0960-894x(01)00270-0
Cytomegalovirus Cytomegalovirus IC50 590.0 nM 10.1016/j.ejmech.2020.112652
Cytomegalovirus Cytomegalovirus IC50 1900.0 nM 10.1016/j.ejmech.2021.113867
Cytomegalovirus Cytomegalovirus IC50 3400.0 nM 10.1021/jm00396a021
Cytomegalovirus Cytomegalovirus IC50 8800.0 nM 10.1021/jm00403a005
Cytomegalovirus Cytomegalovirus MIC 0.5 ug.mL-1 10.1021/jm9507901
Cytomegalovirus Cytomegalovirus MIC 0.6 ug.mL-1 10.1021/jm991171l
Cytomegalovirus Cytomegalovirus MIC 0.8 ug.mL-1 10.1021/jm991171l
Cytomegalovirus Cytomegalovirus MIC 0.9 ug.mL-1 10.1021/jm00045a025
Cytomegalovirus Cytomegalovirus MIC 1.0 ug.mL-1 10.1016/S0960-894X(96)00244-2
Cytomegalovirus Cytomegalovirus MIC 3.0 ug.mL-1 10.1021/jm00066a013
Cytomegalovirus Cytomegalovirus MIC 6.2 ug.mL-1 10.1021/jm00066a013
Cytomegalovirus Cytomegalovirus Ratio IC50 256.0 None 10.1016/j.ejmech.2020.112652
Duck hepatitis B virus Duck hepatitis B virus Inhibition nan % 10.1016/s0960-894x(01)00589-3
Escherichia coli Escherichia coli Inhibition 0.63 % 10.6019/CHEMBL4513141
Escherichia coli Escherichia coli MIC 20000.0 nM 10.6019/CHEMBL4513161
Escherichia coli K-12 Endonuclease 4 Potency 12589.3 nM None
Felid alphaherpesvirus 1 Felid alphaherpesvirus 1 Activity nan None 10.1016/j.ejmech.2011.11.021
Felid alphaherpesvirus 1 Felid alphaherpesvirus 1 EC50 0.8 ug.mL-1 10.1016/j.ejmech.2010.07.058
Felid alphaherpesvirus 1 Felid alphaherpesvirus 1 EC50 100.0 ug.mL-1 10.1016/j.ejmech.2010.09.065
Felid alphaherpesvirus 1 Felid alphaherpesvirus 1 EC50 900.0 nM 10.1016/j.ejmech.2013.06.036
Felid alphaherpesvirus 1 Felid alphaherpesvirus 1 EC50 1150.0 nM 10.1016/j.ejmech.2012.07.027
Felid alphaherpesvirus 1 Felid alphaherpesvirus 1 EC50 1200.0 nM 10.1016/j.ejmech.2012.08.042
Felid alphaherpesvirus 1 Felid alphaherpesvirus 1 EC50 1200.0 nM 10.1021/jm801470b
Felid alphaherpesvirus 1 Felid alphaherpesvirus 1 EC50 2600.0 nM 10.1016/j.ejmech.2009.12.002
Felid alphaherpesvirus 1 Felid alphaherpesvirus 1 EC50 4100.0 nM 10.1016/j.ejmech.2012.03.007
Felid alphaherpesvirus 1 Felid alphaherpesvirus 1 EC50 4100.0 nM 10.1016/j.ejmech.2013.05.046
Felid alphaherpesvirus 1 Felid alphaherpesvirus 1 EC50 7300.0 nM 10.1007/s00044-012-0184-x
Felid alphaherpesvirus 1 Felid alphaherpesvirus 1 EC50 7400.0 nM 10.1016/j.bmc.2015.12.008
Felid alphaherpesvirus 1 Felid alphaherpesvirus 1 EC50 8100.0 nM 10.1016/j.bmc.2011.04.016
Feline coronavirus Feline coronavirus Activity nan None 10.1016/j.ejmech.2011.11.021
Feline coronavirus Feline coronavirus EC50 1.7 ug.mL-1 10.1016/j.ejmech.2010.09.065
Feline coronavirus Feline coronavirus EC50 100000.0 nM 10.1016/j.bmc.2015.12.008
Feline coronavirus Feline coronavirus EC50 100000.0 nM 10.1016/j.ejmech.2009.12.002
Feline coronavirus Feline coronavirus EC50 100000.0 nM 10.1016/j.ejmech.2013.05.046
Feline coronavirus Feline coronavirus EC50 100000.0 nM 10.1016/j.ejmech.2013.06.036
Feline coronavirus Feline coronavirus EC50 100000.0 nM 10.1021/jm801470b
Feline infectious peritonitis virus Feline infectious peritonitis virus EC50 100000.0 nM 10.1007/s00044-012-0184-x
Hepacivirus hominis Hepatitis C virus Activity nan None 10.1021/jm900126v
Hepatitis B virus Hepatitis B virus Activity nan None 10.1021/jm900126v
Hepatitis B virus Hepatitis B virus EC50 4000.0 nM 10.1021/jm010227k
Hepatitis B virus Hepatitis B virus IC50 45.0 ug.mL-1 10.1016/s0960-894x(01)00270-0
Hepatitis B virus Hepatitis B virus Inhibition nan % 10.1021/jm060102l
Hepatitis C virus genotype 1a (isolate 1) (HCV) Hepatitis C virus polyprotein IC50 nan nM 10.1016/s0960-894x(00)00402-9
Herpes simplex virus (type 1 / strain 17) Human herpesvirus 1 DNA polymerase DP 10.0 % 10.1021/jm00120a010
Herpes simplex virus (type 1 / strain 17) Human herpesvirus 1 DNA polymerase Inhibition 60.0 % 10.1021/jm00120a010
Herpes simplex virus (type 1 / strain 17) Human herpesvirus 1 DNA polymerase MP 3.0 % 10.1021/jm00120a010
Herpes simplex virus (type 1 / strain 17) Human herpesvirus 1 DNA polymerase MP 90.0 % 10.1021/jm00120a010
Herpes simplex virus (type 1 / strain 17) Human herpesvirus 1 DNA polymerase TP 84.0 % 10.1021/jm00120a010
Homo sapiens Acetylcholinesterase IC50 nan None None
Homo sapiens Acetylcholinesterase Ki nan None None
Homo sapiens Adenosine A1 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Adenosine A1 receptor IC50 nan None None
Homo sapiens Adenosine A1 receptor Ki nan None None
Homo sapiens Adenosine A2a receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Adenosine A2a receptor IC50 nan None None
Homo sapiens Adenosine A2a receptor Ki nan None None
Homo sapiens Adenosine A3 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Adenosine A3 receptor IC50 nan None None
Homo sapiens Adenosine A3 receptor Ki nan None None
Homo sapiens Aldehyde dehydrogenase 1A1 Potency 39810.7 nM None
Homo sapiens Alpha-1a adrenergic receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-1d adrenergic receptor IC50 nan None None
Homo sapiens Alpha-1d adrenergic receptor Ki nan None None
Homo sapiens Alpha-2a adrenergic receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-2a adrenergic receptor IC50 nan None None
Homo sapiens Alpha-2a adrenergic receptor Ki nan None None
Homo sapiens Alpha-2b adrenergic receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-2b adrenergic receptor IC50 nan None None
Homo sapiens Alpha-2b adrenergic receptor Ki nan None None
Homo sapiens Alpha-2c adrenergic receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-2c adrenergic receptor IC50 nan None None
Homo sapiens Alpha-2c adrenergic receptor Ki nan None None
Homo sapiens Angiotensin II type 2 (AT-2) receptor IC50 nan None None
Homo sapiens Angiotensin II type 2 (AT-2) receptor Ki nan None None
Homo sapiens Beta-1 adrenergic receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Beta-1 adrenergic receptor IC50 nan None None
Homo sapiens Beta-1 adrenergic receptor Ki nan None None
Homo sapiens Beta-2 adrenergic receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Beta-2 adrenergic receptor IC50 nan None None
Homo sapiens Beta-2 adrenergic receptor Ki nan None None
Homo sapiens Beta-3 adrenergic receptor IC50 nan None None
Homo sapiens Beta-3 adrenergic receptor Ki nan None None
Homo sapiens Bile salt export pump AC50 300000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Bile salt export pump IC50 133000.0 nM 10.1093/toxsci/kft176
Homo sapiens Bile salt export pump IC50 135000.0 nM 10.1093/toxsci/kfq269
Homo sapiens Bloom syndrome protein Potency 3.2 nM None
Homo sapiens Bradykinin B2 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Bradykinin B2 receptor IC50 nan None None
Homo sapiens Bradykinin B2 receptor Ki nan None None
Homo sapiens Caco-2 logPapp -6.32 None 10.1016/j.bmc.2011.03.011
Homo sapiens Caco-2 logPapp -6.27 None 10.1016/j.bmc.2009.08.022
Homo sapiens Calcitonin receptor IC50 nan None None
Homo sapiens Calcitonin receptor Ki nan None None
Homo sapiens Canalicular multispecific organic anion transporter 1 IC50 133000.0 nM 10.1093/toxsci/kft176
Homo sapiens Canalicular multispecific organic anion transporter 2 IC50 133000.0 nM 10.1093/toxsci/kft176
Homo sapiens Cannabinoid CB1 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Cannabinoid CB1 receptor IC50 nan None None
Homo sapiens Cannabinoid CB1 receptor Ki nan None None
Homo sapiens Carbonic anhydrase II IC50 nan None None
Homo sapiens Carbonic anhydrase II Ki nan None None
Homo sapiens Caspase-1 IC50 nan None None
Homo sapiens Caspase-1 Ki nan None None
Homo sapiens Cathepsin G IC50 nan None None
Homo sapiens Cathepsin G Ki nan None None
Homo sapiens C-C chemokine receptor type 2 IC50 nan None None
Homo sapiens C-C chemokine receptor type 2 Ki nan None None
Homo sapiens C-C chemokine receptor type 4 IC50 nan None None
Homo sapiens C-C chemokine receptor type 4 Ki nan None None
Homo sapiens C-C chemokine receptor type 5 IC50 nan None None
Homo sapiens C-C chemokine receptor type 5 Ki nan None None
Homo sapiens CCRF-CEM CC50 5000.0 nM 10.1021/jm040093l
Homo sapiens CCRF-CEM CC50 100000.0 nM 10.1021/acs.jmedchem.7b01009
Homo sapiens CCRF-CEM CC50 200000.0 nM 10.1016/j.bmcl.2003.09.033
Homo sapiens CCRF-CEM EC50 200000.0 nM 10.1016/j.bmcl.2003.09.033
Homo sapiens CCRF-CEM IC50 390000.0 nM 10.1016/s0960-894x(01)00735-1
Homo sapiens CCRF-CEM IC50 nan nM 10.1016/s0960-894x(01)00735-1
Homo sapiens CCRF-HSB-2 IC50 17.0 ug.mL-1 10.1021/jm9701536
Homo sapiens Cell line CC50 nan ug.mL-1 10.1021/jm040878r
Homo sapiens Cell line MCC 400.0 ug.mL-1 10.1021/jm040878r
Homo sapiens Cerebroside-sulfatase Potency 30.1 nM None
Homo sapiens Cholecystokinin A receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Cholecystokinin A receptor IC50 nan None None
Homo sapiens Cholecystokinin A receptor Ki nan None None
Homo sapiens Cholecystokinin B receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Cyclooxygenase-1 IC50 nan None None
Homo sapiens Cyclooxygenase-1 Ki nan None None
Homo sapiens Cyclooxygenase-2 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Cyclooxygenase-2 IC50 nan None None
Homo sapiens Cyclooxygenase-2 Ki nan None None
Homo sapiens Cysteinyl leukotriene receptor 1 IC50 nan None None
Homo sapiens Cysteinyl leukotriene receptor 1 Ki nan None None
Homo sapiens Cytochrome P450 1A2 AC50 nan None None
Homo sapiens Cytochrome P450 1A2 IC50 nan None None
Homo sapiens Cytochrome P450 1A2 Ki nan None None
Homo sapiens Cytochrome P450 2A6 IC50 nan None None
Homo sapiens Cytochrome P450 2A6 Ki nan None None
Homo sapiens Cytochrome P450 2C19 AC50 nan None None
Homo sapiens Cytochrome P450 2C19 IC50 nan None None
Homo sapiens Cytochrome P450 2C19 Ki nan None None
Homo sapiens Cytochrome P450 2C9 AC50 nan None None
Homo sapiens Cytochrome P450 2C9 FC 1.0 None 10.1016/j.bmcl.2016.06.088
Homo sapiens Cytochrome P450 2C9 IC50 nan None None
Homo sapiens Cytochrome P450 2C9 Ki nan None None
Homo sapiens Cytochrome P450 2D6 AC50 nan None None
Homo sapiens Cytochrome P450 2D6 FC 1.0 None 10.1016/j.bmcl.2016.06.088
Homo sapiens Cytochrome P450 2D6 IC50 nan None None
Homo sapiens Cytochrome P450 2D6 Ki nan None None
Homo sapiens Cytochrome P450 2E1 IC50 nan None None
Homo sapiens Cytochrome P450 2E1 Ki nan None None
Homo sapiens Cytochrome P450 3A4 AC50 25118.86 nM None
Homo sapiens Cytochrome P450 3A4 AC50 nan None None
Homo sapiens Cytochrome P450 3A4 FC 1.0 None 10.1016/j.bmcl.2016.06.088
Homo sapiens Cytochrome P450 3A4 IC50 nan None None
Homo sapiens Cytochrome P450 3A4 Ki nan None None
Homo sapiens Cytochrome P450 3A4 Potency 25118.9 nM None
Homo sapiens Delta opioid receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Delta opioid receptor IC50 nan None None
Homo sapiens Delta opioid receptor Ki nan None None
Homo sapiens DNA-(apurinic or apyrimidinic site) lyase Potency 14125.4 nM None
Homo sapiens DNA polymerase alpha subunit IC50 nan nM 10.1016/s0960-894x(00)00402-9
Homo sapiens DNA polymerase alpha subunit Inhibition 17.0 % 10.1021/jm00155a039
Homo sapiens DNA polymerase iota Potency 39810.7 nM None
Homo sapiens Dopamine D1 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine D1 receptor IC50 nan None None
Homo sapiens Dopamine D1 receptor Ki nan None None
Homo sapiens Dopamine D2 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine D2 receptor IC50 nan None None
Homo sapiens Dopamine D2 receptor Ki nan None None
Homo sapiens Dopamine D3 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine D3 receptor IC50 nan None None
Homo sapiens Dopamine D3 receptor Ki nan None None
Homo sapiens Dopamine D4 receptor IC50 nan None None
Homo sapiens Dopamine D4 receptor Ki nan None None
Homo sapiens Dopamine transporter AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine transporter IC50 nan None None
Homo sapiens Dopamine transporter Ki nan None None
Homo sapiens E6SM CC50 100.0 ug.mL-1 10.1021/jm9507901
Homo sapiens E6SM Cytotoxicity 50.0 None 10.1021/jm991171l
Homo sapiens E6SM EC50 0.003 ug.mL-1 10.1021/jm049806q
Homo sapiens E6SM EC50 0.004 ug.mL-1 10.1021/jm049806q
Homo sapiens E6SM EC50 1.2 nM 10.1021/jm0108350
Homo sapiens E6SM EC50 2.4 ug.mL-1 10.1021/jm049806q
Homo sapiens E6SM EC50 100.0 ug.mL-1 10.1021/jm049806q
Homo sapiens E6SM EC50 100000.0 nM 10.1021/jm0108350
Homo sapiens E6SM MCC 100.0 ug.mL-1 10.1016/j.ejmech.2007.04.010
Homo sapiens E6SM MCC 100.0 ug.mL-1 10.1016/s0960-894x(01)00838-1
Homo sapiens E6SM MCC 100.0 ug.mL-1 10.1021/jm0108404
Homo sapiens E6SM MCC 100.0 ug.mL-1 10.1021/jm025569k
Homo sapiens E6SM MCC 100.0 ug.mL-1 10.1021/jm049806q
Homo sapiens E6SM MCC 100.0 ug.mL-1 10.1021/jm0701472
Homo sapiens E6SM MIC 0.001 ug.mL-1 10.1021/jm960500w
Homo sapiens E6SM MIC 0.002 ug.mL-1 10.1021/jm960500w
Homo sapiens E6SM MIC 0.003 ug.mL-1 10.1021/jm960500w
Homo sapiens E6SM MIC 0.004 ug.mL-1 10.1021/jm0108404
Homo sapiens E6SM MIC 0.006 ug.mL-1 10.1021/jm960500w
Homo sapiens E6SM MIC 0.0064 ug.mL-1 10.1016/s0960-894x(01)00838-1
Homo sapiens E6SM MIC 0.019 ug.mL-1 10.1016/s0960-894x(01)00838-1
Homo sapiens E6SM MIC 0.019 ug.mL-1 10.1021/jm0108404
Homo sapiens E6SM MIC 1.92 ug.mL-1 10.1021/jm0108404
Homo sapiens E6SM MIC 5.0 ug.mL-1 10.1021/jm960500w
Homo sapiens E6SM MIC 9.6 ug.mL-1 10.1016/s0960-894x(01)00838-1
Homo sapiens E6SM MIC 100.0 ug.mL-1 10.1016/s0960-894x(01)00838-1
Homo sapiens E6SM MIC 100.0 ug.mL-1 10.1021/jm0108404
Homo sapiens E6SM MIC 270.0 ug.mL-1 10.1021/jm00045a025
Homo sapiens E6SM MIC 100000.0 nM 10.1016/j.bmc.2006.10.046
Homo sapiens E6SM MIC 1600000.0 nM 10.1021/jm0108350
Homo sapiens Endothelin receptor ET-A AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Endothelin receptor ET-A IC50 nan None None
Homo sapiens Endothelin receptor ET-A Ki nan None None
Homo sapiens Epidermal growth factor receptor erbB1 IC50 nan None None
Homo sapiens Epidermal growth factor receptor erbB1 Ki nan None None
Homo sapiens Equilibrative nucleoside transporter 1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Estrogen receptor alpha AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Estrogen receptor alpha IC50 nan None None
Homo sapiens Estrogen receptor alpha Ki nan None None
Homo sapiens Estrogen receptor beta IC50 nan None None
Homo sapiens Estrogen receptor beta Ki nan None None
Homo sapiens F2002 cell line CD50 100.0 ug ml-1 10.1016/S0960-894X(97)00245-X
Homo sapiens F2002 cell line CD50 100.0 ug ml-1 10.1016/s0960-894x(98)00648-9
Homo sapiens F2002 cell line IC50 0.1 ug.mL-1 10.1016/S0960-894X(01)80693-4
Homo sapiens F2002 cell line IC50 0.1 ug.mL-1 10.1016/s0960-894x(98)00648-9
Homo sapiens F2002 cell line IC50 0.2 ug.mL-1 10.1016/s0960-894x(98)00648-9
Homo sapiens F2002 cell line PD50 0.1 ug ml-1 10.1016/S0960-894X(97)00245-X
Homo sapiens Geminin Potency 3264.3 nM None
Homo sapiens Ghrelin receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Glucocorticoid receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Glucocorticoid receptor IC50 nan None None
Homo sapiens Glucocorticoid receptor Ki nan None None
Homo sapiens HEK293 CC50 20000.0 nM 10.6019/CHEMBL4513161
Homo sapiens HEL Activity 83.6 ug ml-1 10.1021/jm061281+
Homo sapiens HEL Activity 100.0 ug ml-1 10.1016/j.ejmech.2010.07.058
Homo sapiens HEL Activity 100.0 ug ml-1 10.1021/jm061281+
Homo sapiens HEL CC 100.0 ug ml-1 10.1021/jm981051y
Homo sapiens HEL CC50 34.0 ug.mL-1 10.1021/jm051023x
Homo sapiens HEL CC50 50.0 ug.mL-1 10.1016/s0960-894x(02)00535-8
Homo sapiens HEL CC50 50.0 ug.mL-1 10.1021/jm980327z
Homo sapiens HEL CC50 60.5 ug.mL-1 10.1007/s00044-011-9776-0
Homo sapiens HEL CC50 65.4 ug.mL-1 10.1021/jm040869i
Homo sapiens HEL CC50 80.0 ug.mL-1 10.1016/j.ejmech.2009.02.030
Homo sapiens HEL CC50 87.0 ug.mL-1 10.1016/j.ejmech.2007.04.010
Homo sapiens HEL CC50 122.0 ug.mL-1 10.1021/jm0707166
Homo sapiens HEL CC50 146.0 ug.mL-1 10.1016/j.bmc.2007.03.061
Homo sapiens HEL CC50 146.0 ug.mL-1 10.1016/j.bmc.2008.09.027
Homo sapiens HEL CC50 200.0 ug.mL-1 10.1016/S0960-894X(01)80538-2
Homo sapiens HEL CC50 200.0 ug.mL-1 10.1021/jm00005a010
Homo sapiens HEL CC50 400.0 ug.mL-1 10.1016/j.ejmech.2009.02.030
Homo sapiens HEL CC50 100000.0 nM 10.1016/j.ejmech.2009.12.002
Homo sapiens HEL CC50 100000.0 nM 10.1021/jm060030y
Homo sapiens HEL CC50 130000.0 nM 10.1016/j.ejmech.2012.04.001
Homo sapiens HEL CC50 134000.0 nM 10.1021/jm8014662
Homo sapiens HEL CC50 150000.0 nM 10.1016/j.bmcl.2003.08.028
Homo sapiens HEL CC50 150000.0 nM 10.1016/j.bmcl.2004.02.010
Homo sapiens HEL CC50 150000.0 nM 10.1021/jm030857h
Homo sapiens HEL CC50 150000.0 nM 10.1021/jm0492812
Homo sapiens HEL CC50 164000.0 nM 10.1021/jm1011462
Homo sapiens HEL CC50 172000.0 nM 10.1016/j.ejmech.2007.09.001
Homo sapiens HEL CC50 172000.0 nM 10.1021/jm0614329
Homo sapiens HEL CC50 197000.0 nM 10.1021/jm050867d
Homo sapiens HEL CC50 200000.0 nM 10.1016/j.bmc.2013.05.009
Homo sapiens HEL CC50 200000.0 nM 10.1021/jm070210n
Homo sapiens HEL CC50 221000.0 nM 10.1016/j.ejmech.2009.03.005
Homo sapiens HEL CC50 231000.0 nM 10.1016/j.ejmech.2012.07.027
Homo sapiens HEL CC50 231220.0 nM 10.1021/acsmedchemlett.0c00485
Homo sapiens HEL CC50 250000.0 nM 10.1016/j.ejmech.2010.12.017
Homo sapiens HEL CC50 262000.0 nM 10.1021/jm070324z
Homo sapiens HEL CC50 273000.0 nM 10.1021/acs.jmedchem.7b01009
Homo sapiens HEL CC50 300000.0 nM 10.1016/j.ejmech.2021.113467
Homo sapiens HEL CC50 308000.0 nM 10.1016/j.bmc.2017.06.046
Homo sapiens HEL CC50 319000.0 nM 10.1016/j.bmc.2015.09.033
Homo sapiens HEL CC50 319000.0 nM 10.1021/acsmedchemlett.8b00079
Homo sapiens HEL CC50 328500.0 nM 10.1016/j.ejmech.2015.08.008
Homo sapiens HEL CC50 350000.0 nM 10.1016/j.ejmech.2013.06.053
Homo sapiens HEL CC50 350000.0 nM 10.1016/j.ejmech.2016.10.002
Homo sapiens HEL CC50 350000.0 nM 10.1016/j.ejmech.2018.01.086
Homo sapiens HEL CC50 391000.0 nM 10.1016/j.ejmech.2018.03.008
Homo sapiens HEL CC50 391000.0 nM 10.1021/acs.jmedchem.7b00416
Homo sapiens HEL CC50 394000.0 nM 10.1021/acsmedchemlett.0c00090
Homo sapiens HEL CC50 394000.0 nM 10.1021/jm000118q
Homo sapiens HEL CC50 400000.0 nM 10.1016/j.bmcl.2003.09.033
Homo sapiens HEL CC50 435000.0 nM 10.1016/j.bmc.2011.04.016
Homo sapiens HEL CC50 543000.0 nM 10.1016/j.bmc.2011.06.045
Homo sapiens HEL CC50 1077000.0 nM 10.1021/jm901828c
Homo sapiens HEL CC50 nan ug.mL-1 10.1016/s0960-894x(02)00535-8
Homo sapiens HEL Cytotoxicity 50.0 None 10.1021/jm991171l
Homo sapiens HEL EC50 0.00056 ug.mL-1 10.1021/jm0707166
Homo sapiens HEL EC50 0.9 ug.mL-1 10.1021/jm0707166
Homo sapiens HEL EC50 60.0 nM 10.1016/j.bmcl.2003.09.033
Homo sapiens HEL EC50 500.0 nM 10.1021/jm049806q
Homo sapiens HEL EC50 800.0 nM 10.1016/j.bmcl.2004.02.010
Homo sapiens HEL EC50 900.0 nM 10.1016/j.bmcl.2004.02.010
Homo sapiens HEL EC50 1500.0 nM 10.1021/jm0492812
Homo sapiens HEL EC50 1500.0 nM 10.1021/jm049806q
Homo sapiens HEL EC50 2700.0 nM 10.1021/jm030857h
Homo sapiens HEL EC50 3900.0 nM 10.1021/jm030857h
Homo sapiens HEL EC50 7800.0 nM 10.1021/jm0108350
Homo sapiens HEL EC50 11800.0 nM 10.1021/jm0108350
Homo sapiens HEL EC50 nan nM 10.1016/j.bmcl.2003.09.033
Homo sapiens HEL EC50 nan None 10.1021/jm000118q
Homo sapiens HEL IC50 0.02 ug.mL-1 10.1021/jm00005a010
Homo sapiens HEL IC50 0.072 ug.mL-1 10.1021/jm00005a010
Homo sapiens HEL IC50 0.1 ug.mL-1 10.1021/jm00005a010
Homo sapiens HEL IC50 0.9 ug.mL-1 10.1021/jm00005a010
Homo sapiens HEL IC50 1.2 ug.mL-1 10.1016/S0960-894X(97)00149-2
Homo sapiens HEL IC50 1.3 ug.mL-1 10.1016/S0960-894X(97)00149-2
Homo sapiens HEL IC50 1.5 ug.mL-1 10.1016/S0960-894X(01)80538-2
Homo sapiens HEL IC50 2.0 ug.mL-1 10.1016/S0960-894X(01)80538-2
Homo sapiens HEL IC50 2.7 ug.mL-1 10.1016/j.bmcl.2005.01.050
Homo sapiens HEL IC50 2.9 ug.mL-1 10.1021/jm00005a010
Homo sapiens HEL IC50 6.2 ug.mL-1 10.1021/jm00005a010
Homo sapiens HEL IC50 500.0 nM 10.1021/jm00010a026
Homo sapiens HEL IC50 1000.0 nM 10.1021/jm991017z
Homo sapiens HEL IC50 5000.0 nM 10.1021/jm991017z
Homo sapiens HEL IC50 7000.0 nM 10.1021/jm00010a026
Homo sapiens HEL IC50 50000.0 nM 10.1021/jm991017z
Homo sapiens HEL IC50 nan nM 10.1021/jm991017z
Homo sapiens HEL IC50 nan ug.mL-1 10.1021/jm981051y
Homo sapiens HEL IC90 2100.0 nM 10.1021/jm00010a026
Homo sapiens HEL MCC 50.0 ug.mL-1 10.1016/s0960-894x(01)00838-1
Homo sapiens HEL MCC 50.0 ug.mL-1 10.1016/s0960-894x(02)00535-8
Homo sapiens HEL MCC 50.0 ug.mL-1 10.1021/jm980327z
Homo sapiens HEL MCC 89.0 ug.mL-1 10.1021/jm00090a007
Homo sapiens HEL MCC 100.0 ug.mL-1 10.1007/s00044-011-9776-0
Homo sapiens HEL MCC 100.0 ug.mL-1 10.1007/s00044-012-0127-6
Homo sapiens HEL MCC 100.0 ug.mL-1 10.1016/j.bmc.2007.03.061
Homo sapiens HEL MCC 100.0 ug.mL-1 10.1016/j.bmc.2008.09.027
Homo sapiens HEL MCC 100.0 ug.mL-1 10.1016/j.ejmech.2007.04.010
Homo sapiens HEL MCC 100.0 ug.mL-1 10.1016/j.ejmech.2008.08.010
Homo sapiens HEL MCC 100.0 ug.mL-1 10.1016/j.ejmech.2009.02.030
Homo sapiens HEL MCC 100.0 ug.mL-1 10.1016/j.ejmech.2009.03.038
Homo sapiens HEL MCC 100.0 ug.mL-1 10.1016/j.ejmech.2010.09.065
Homo sapiens HEL MCC 100.0 ug.mL-1 10.1016/S0960-894X(01)80538-2
Homo sapiens HEL MCC 100.0 ug.mL-1 10.1021/jm050772b
Homo sapiens HEL MCC 100.0 ug.mL-1 10.1021/jm0707166
Homo sapiens HEL MCC 400.0 ug.mL-1 10.1021/jm040869i
Homo sapiens HEL MCC 400.0 ug.mL-1 10.1021/jm051023x
Homo sapiens HEL MCC 39200.0 nM 10.1021/acsmedchemlett.8b00079
Homo sapiens HEL MCC 100000.0 nM 10.1007/s00044-009-9248-y
Homo sapiens HEL MCC 100000.0 nM 10.1007/s00044-012-0184-x
Homo sapiens HEL MCC 100000.0 nM 10.1016/j.bmc.2008.08.041
Homo sapiens HEL MCC 100000.0 nM 10.1016/j.bmc.2011.05.037
Homo sapiens HEL MCC 100000.0 nM 10.1016/j.bmc.2015.04.079
Homo sapiens HEL MCC 100000.0 nM 10.1016/j.bmc.2015.12.008
Homo sapiens HEL MCC 100000.0 nM 10.1016/j.bmc.2018.05.034
Homo sapiens HEL MCC 100000.0 nM 10.1016/j.bmcl.2012.09.079
Homo sapiens HEL MCC 100000.0 nM 10.1016/j.bmcl.2018.09.019
Homo sapiens HEL MCC 100000.0 nM 10.1016/j.ejmech.2012.03.007
Homo sapiens HEL MCC 100000.0 nM 10.1016/j.ejmech.2013.05.046
Homo sapiens HEL MCC 100000.0 nM 10.1016/j.ejmech.2013.06.036
Homo sapiens HEL MCC 100000.0 nM 10.1016/j.ejmech.2016.10.002
Homo sapiens HEL MCC 100000.0 nM 10.1016/j.ejmech.2022.114618
Homo sapiens HEL MCC 100000.0 nM 10.1021/acs.jmedchem.7b01009
Homo sapiens HEL MCC 100000.0 nM 10.1021/jm1011462
Homo sapiens HEL MCC 100000.0 nM 10.1021/jm801470b
Homo sapiens HEL MCC 100000.0 nM 10.1021/ml2001054
Homo sapiens HEL MCC 150000.0 nM 10.1016/j.bmcl.2003.08.028
Homo sapiens HEL MCC 150000.0 nM 10.1021/jm000118q
Homo sapiens HEL MCC 150000.0 nM 10.1021/jm030857h
Homo sapiens HEL MCC 197000.0 nM 10.1021/jm050867d
Homo sapiens HEL MCC 200000.0 nM 10.1021/jm0701472
Homo sapiens HEL MCC 200000.0 nM 10.1021/jm070210n
Homo sapiens HEL MCC 250000.0 nM 10.1016/j.bmc.2019.02.005
Homo sapiens HEL MCC 250000.0 nM 10.1016/j.ejmech.2010.12.017
Homo sapiens HEL MCC 350000.0 nM 10.1016/j.bmc.2015.09.033
Homo sapiens HEL MCC 350000.0 nM 10.1016/j.bmc.2017.06.046
Homo sapiens HEL MCC 350000.0 nM 10.1016/j.ejmech.2012.04.001
Homo sapiens HEL MCC 350000.0 nM 10.1016/j.ejmech.2015.08.008
Homo sapiens HEL MCC 350000.0 nM 10.1016/j.ejmech.2016.10.002
Homo sapiens HEL MCC 350000.0 nM 10.1016/j.ejmech.2018.01.086
Homo sapiens HEL MCC 350000.0 nM 10.1021/acsmedchemlett.0c00485
Homo sapiens HEL MCC 391000.0 nM 10.1016/j.ejmech.2018.03.008
Homo sapiens HEL MCC 391000.0 nM 10.1021/acs.jmedchem.7b00416
Homo sapiens HEL MCC 392000.0 nM 10.1016/j.bmc.2011.04.016
Homo sapiens HEL MCC 392000.0 nM 10.1021/jm901828c
Homo sapiens HEL MCC 394000.0 nM 10.1016/j.bmc.2011.06.045
Homo sapiens HEL MCC 394000.0 nM 10.1016/j.bmc.2013.05.009
Homo sapiens HEL MCC 394000.0 nM 10.1016/j.ejmech.2012.07.027
Homo sapiens HEL MCC 394000.0 nM 10.1021/acsmedchemlett.0c00090
Homo sapiens HEL MCC 400000.0 nM 10.1021/jm8014662
Homo sapiens HEL MCC 1500000.0 nM 10.1021/jm0492812
Homo sapiens HEL MCC 1575000.0 nM 10.1016/j.ejmech.2007.09.001
Homo sapiens HEL MCC 1575000.0 nM 10.1016/j.ejmech.2009.03.005
Homo sapiens HEL MCC 1575000.0 nM 10.1021/jm0614329
Homo sapiens HEL MCC 1575000.0 nM 10.1021/jm070324z
Homo sapiens HEL MCC nan ug.mL-1 10.1016/s0960-894x(02)00535-8
Homo sapiens HEL MIC 0.13 ug.mL-1 10.1021/jm960770e
Homo sapiens HEL MIC 0.3 ug.mL-1 10.1021/jm00090a007
Homo sapiens HEL MIC 0.8 ug.mL-1 10.1021/jm00090a007
Homo sapiens HEL MIC 1.0 ug.mL-1 10.1021/jm00112a010
Homo sapiens HEL MIC 1.5 ug.mL-1 10.1021/jm960770e
Homo sapiens HEL MIC 2.0 ug.mL-1 10.1016/s0960-894x(01)00838-1
Homo sapiens HEL MIC 3.0 ug.mL-1 10.1021/jm00090a007
Homo sapiens HEL MIC 85.0 ug.mL-1 10.1021/jm00066a013
Homo sapiens HEL MIC 90.0 ug.mL-1 10.1021/jm00112a010
Homo sapiens HEL MIC 200.0 ug.mL-1 10.1021/jm00045a025
Homo sapiens HEL MIC 150000.0 nM 10.1021/jm0108350
Homo sapiens HEL MIC nan ug.mL-1 10.1021/jm00112a010
Homo sapiens HEL 299 CC50 10.0 ug.mL-1 10.1021/jm000342f
Homo sapiens HEL 299 CC50 400.0 ug.mL-1 10.1016/S0960-894X(00)80078-5
Homo sapiens HEL 299 CC50 50000.0 nM 10.1016/j.ejmech.2021.113640
Homo sapiens HEL 299 CC50 100000.0 nM 10.1021/jm980321+
Homo sapiens HeLa CC50 50.0 ug.mL-1 10.1016/j.ejmech.2009.02.030
Homo sapiens HeLa CC50 50.0 ug.mL-1 10.1016/S0960-894X(97)00149-2
Homo sapiens HeLa CC50 190.0 ug.mL-1 10.1016/j.ejmech.2009.02.030
Homo sapiens HeLa CC50 221800.0 nM 10.1016/j.ejmech.2012.03.007
Homo sapiens HeLa EC50 100000.0 nM 10.1021/jm0108350
Homo sapiens HeLa MCC 100000.0 nM 10.1016/j.ejmech.2013.06.036
Homo sapiens HeLa MCC nan None 10.1016/j.bmc.2015.12.008
Homo sapiens HeLa MCC nan None 10.1021/jm050772b
Homo sapiens HEp-2 Concentration 3200.0 uM 10.1021/jm00117a021
Homo sapiens HepG2 CC50 nan None 10.1021/jm060102l
Homo sapiens HERG AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens HERG IC50 nan None None
Homo sapiens HERG Ki nan None None
Homo sapiens HFF CC50 50000.0 nM 10.1021/acs.jmedchem.2c00203
Homo sapiens HFF CC50 100000.0 nM 10.1016/j.bmc.2007.11.082
Homo sapiens HFF CC50 100000.0 nM 10.1016/j.bmc.2015.07.039
Homo sapiens HFF CC50 100000.0 nM 10.1016/j.bmcl.2007.01.109
Homo sapiens HFF CC50 100000.0 nM 10.1016/j.bmcl.2007.03.102
Homo sapiens HFF CC50 100000.0 nM 10.1016/j.bmcl.2008.06.060
Homo sapiens HFF CC50 100000.0 nM 10.1016/j.bmcl.2010.03.115
Homo sapiens HFF CC50 100000.0 nM 10.1016/j.ejmech.2011.02.014
Homo sapiens HFF CC50 100000.0 nM 10.1021/jm040093l
Homo sapiens HFF CC50 100000.0 nM 10.1021/jm040149b
Homo sapiens HFF CC50 100000.0 nM 10.1021/jm050162b
Homo sapiens HFF CC50 100000.0 nM 10.1021/jm0607404
Homo sapiens HFF CC50 100000.0 nM 10.1021/jm900126v
Homo sapiens HFF CC50 150000.0 nM 10.1021/acs.jmedchem.2c00667
Homo sapiens HFF CC50 150000.0 nM 10.1039/d1md00086a
Homo sapiens HFF CC50 200000.0 nM 10.1021/acs.jmedchem.9b01501
Homo sapiens HFF CC50 300000.0 nM 10.1016/j.bmc.2012.04.049
Homo sapiens HFF CC50 392000.0 nM 10.1021/jm030316s
Homo sapiens HFF CC50 392000.0 nM 10.1021/jm040093l
Homo sapiens HFF CC50 392000.0 nM 10.1021/jm040149b
Homo sapiens HFF CC50 550000.0 nM 10.1128/aac.00988-08
Homo sapiens HFF CC50 550000.0 nM 10.1128/aac.01730-09
Homo sapiens HFF CC50 nan None 10.1016/j.ejmech.2011.02.014
Homo sapiens HFF CC50 nan None 10.1021/acs.jmedchem.2c00667
Homo sapiens HFF IC50 4.4 ug.mL-1 10.1021/jm00020a009
Homo sapiens HFF IC50 52.0 ug.mL-1 10.1021/jm00020a009
Homo sapiens HFF IC50 600.0 nM 10.1016/s0960-894x(00)00402-9
Homo sapiens HFF IC50 800.0 nM 10.1021/jm050162b
Homo sapiens HFF IC50 1200.0 nM 10.1021/jm0400606
Homo sapiens HFF IC50 1300.0 nM 10.1021/jm050162b
Homo sapiens HFF IC50 2500.0 nM 10.1021/jm0400606
Homo sapiens HFF IC50 2600.0 nM 10.1021/jm9705723
Homo sapiens HFF IC50 4100.0 nM 10.1021/jm990195p
Homo sapiens HFF IC50 4500.0 nM 10.1021/jm990195p
Homo sapiens HFF IC50 7400.0 nM 10.1021/jm040032n
Homo sapiens HFF IC50 7400.0 nM 10.1021/jm0400606
Homo sapiens HFF IC50 7400.0 nM 10.1021/jm9705723
Homo sapiens HFF IC50 7400.0 nM 10.1021/jm990195p
Homo sapiens HFF IC50 7400.0 nM 10.1021/jm990219s
Homo sapiens HFF IC50 7400.0 nM 10.1021/jm990290y
Homo sapiens HFF IC50 7400.0 nM 10.1021/jm990320x
Homo sapiens HFF IC50 7700.0 nM 10.1021/jm960631x
Homo sapiens HFF IC50 8400.0 nM 10.1016/S0960-894X(00)80470-9
Homo sapiens HFF IC50 100000.0 nM 10.1016/j.bmcl.2006.06.066
Homo sapiens HFF IC50 100000.0 nM 10.1016/S0960-894X(00)80628-9
Homo sapiens HFF IC50 100000.0 nM 10.1021/jm00020a025
Homo sapiens HFF IC50 100000.0 nM 10.1021/jm00020a026
Homo sapiens HFF IC50 100000.0 nM 10.1021/jm00020a027
Homo sapiens HFF IC50 100000.0 nM 10.1021/jm00076a011
Homo sapiens HFF IC50 100000.0 nM 10.1021/jm00119a006
Homo sapiens HFF IC50 100000.0 nM 10.1021/jm00169a027
Homo sapiens HFF IC50 100000.0 nM 10.1021/jm00174a011
Homo sapiens HFF IC50 100000.0 nM 10.1021/jm00403a005
Homo sapiens HFF IC50 100000.0 nM 10.1021/jm0400146
Homo sapiens HFF IC50 100000.0 nM 10.1021/jm040016q
Homo sapiens HFF IC50 100000.0 nM 10.1021/jm040032n
Homo sapiens HFF IC50 100000.0 nM 10.1021/jm0400606
Homo sapiens HFF IC50 100000.0 nM 10.1021/jm2001426
Homo sapiens HFF IC50 100000.0 nM 10.1021/jm950556a
Homo sapiens HFF IC50 100000.0 nM 10.1021/jm950835y
Homo sapiens HFF IC50 100000.0 nM 10.1021/jm960157v
Homo sapiens HFF IC50 100000.0 nM 10.1021/jm960462g
Homo sapiens HFF IC50 100000.0 nM 10.1021/jm9604888
Homo sapiens HFF IC50 100000.0 nM 10.1021/jm960533b
Homo sapiens HFF IC50 100000.0 nM 10.1021/jm960631x
Homo sapiens HFF IC50 100000.0 nM 10.1021/jm970532z
Homo sapiens HFF IC50 100000.0 nM 10.1021/jm990195p
Homo sapiens HFF IC50 100000.0 nM 10.1021/jm990219s
Homo sapiens HFF IC50 100000.0 nM 10.1021/jm990290y
Homo sapiens HFF IC50 100000.0 nM 10.1021/jm990320x
Homo sapiens HFF IC50 nan nM 10.1021/jm050162b
Homo sapiens HFF IC50 nan nM 10.1021/jm9705723
Homo sapiens HFF IC90 1600.0 nM 10.1021/jm9705723
Homo sapiens HFF IC90 1600.0 nM 10.1021/jm990195p
Homo sapiens HFF IC90 1600.0 nM 10.1021/jm990219s
Homo sapiens HFF IC90 1600.0 nM 10.1021/jm990290y
Homo sapiens HFF IC90 1600.0 nM 10.1021/jm990320x
Homo sapiens HFF IC90 1800.0 nM 10.1021/jm960631x
Homo sapiens HFF IC90 3300.0 nM 10.1021/jm990195p
Homo sapiens HFF IC90 3600.0 nM 10.1021/jm990195p
Homo sapiens HFF TC50 1000.0 ug ml-1 10.1021/jm00020a009
Homo sapiens Histamine H1 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Histamine H1 receptor IC50 nan None None
Homo sapiens Histamine H1 receptor Ki nan None None
Homo sapiens Histamine H2 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Histamine H2 receptor IC50 nan None None
Homo sapiens Histamine H2 receptor Ki nan None None
Homo sapiens Histamine H3 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Histone deacetylase 6 Inhibition -10.61 % 10.6019/CHEMBL4808148
Homo sapiens Histone deacetylase 6 Inhibition -1.6 % 10.6019/CHEMBL4808148
Homo sapiens Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 Potency 22.4 nM None
Homo sapiens HMG-CoA reductase IC50 nan None None
Homo sapiens HMG-CoA reductase Ki nan None None
Homo sapiens Homo sapiens CL 0.5 mL.min-1.kg-1 10.1021/jm901371v
Homo sapiens Homo sapiens CL 4.6 mL.min-1.kg-1 10.1021/jm900403j
Homo sapiens Homo sapiens CL 4.6 mL.min-1.kg-1 10.1021/jm901371v
Homo sapiens Homo sapiens CL 6.34 L/hr 10.1128/aac.00085-09
Homo sapiens Homo sapiens CL 7.49 L/hr 10.1128/aac.00085-09
Homo sapiens Homo sapiens CL 9.65 L/hr 10.1128/aac.00085-09
Homo sapiens Homo sapiens CL 10.2 L/hr 10.1128/aac.00085-09
Homo sapiens Homo sapiens CL_renal 4.1 mL.min-1.kg-1 10.1021/jm901371v
Homo sapiens Homo sapiens CL_renal 4.14 mL.min-1.kg-1 10.1021/jm900403j
Homo sapiens Homo sapiens Cytotoxicity 0.0 None 10.1021/jm00394a017
Homo sapiens Homo sapiens DILI_Concern nan None 10.1016/j.drudis.2016.02.015
Homo sapiens Homo sapiens DILI_severity_class 7.0 None 10.1016/j.drudis.2016.02.015
Homo sapiens Homo sapiens EC50 500.0 nM 10.1021/jm00069a004
Homo sapiens Homo sapiens EC50 nan nM 10.1021/jm00069a004
Homo sapiens Homo sapiens EC50 nan ug.mL-1 10.1016/s0960-894x(01)00589-3
Homo sapiens Homo sapiens F 0.76 % 10.1128/aac.00085-09
Homo sapiens Homo sapiens F 0.825 % 10.1128/aac.00085-09
Homo sapiens Homo sapiens F 7.3 % 10.1021/jm901421c
Homo sapiens Homo sapiens Fa 0.09 None 10.1021/jm901371v
Homo sapiens Homo sapiens F_fraction 0.09 None 10.1021/jm901371v
Homo sapiens Homo sapiens Fg 1.02 None 10.1021/jm901371v
Homo sapiens Homo sapiens Fh 0.98 None 10.1021/jm901371v
Homo sapiens Homo sapiens IC50 100000.0 nM 10.1021/jm00127a003
Homo sapiens Homo sapiens IC50 100000.0 nM 10.1021/jm970545c
Homo sapiens Homo sapiens IC50 168000.0 nM 10.1021/jm00069a004
Homo sapiens Homo sapiens IC50 390000.0 nM 10.1021/jm00069a004
Homo sapiens Homo sapiens Ka 0.895 /hr 10.1128/aac.00085-09
Homo sapiens Homo sapiens Ka 0.971 /hr 10.1128/aac.00085-09
Homo sapiens Homo sapiens Reduction 0.0 None 10.1021/jm00394a017
Homo sapiens Homo sapiens Reduction 24.0 % 10.1021/jm00394a017
Homo sapiens Homo sapiens Reduction 35.0 % 10.1021/jm00394a017
Homo sapiens Homo sapiens Reduction 56.0 % 10.1021/jm00394a017
Homo sapiens Homo sapiens Reduction 82.0 % 10.1021/jm00394a017
Homo sapiens Homo sapiens Reduction 97.0 % 10.1021/jm00394a017
Homo sapiens Homo sapiens Vd 31.1 l 10.1128/aac.00085-09
Homo sapiens Homo sapiens Vd 31.9 l 10.1128/aac.00085-09
Homo sapiens Homo sapiens Vd 32.0 l 10.1128/aac.00085-09
Homo sapiens Homo sapiens Vdss 1.0 L.kg-1 10.1021/jm901371v
Homo sapiens HS27 CC50 333000.0 nM 10.1128/aac.01596-09
Homo sapiens Hs68 CC50 12.5 ug.mL-1 10.1016/s0960-894x(00)00265-1
Homo sapiens Hs68 CC50 12.5 ug.mL-1 10.1021/jm9902483
Homo sapiens Hypoxia-inducible factor 1 alpha Potency 3981.1 nM None
Homo sapiens Interleukin-8 receptor A IC50 nan None None
Homo sapiens Interleukin-8 receptor A Ki nan None None
Homo sapiens Interleukin-8 receptor B IC50 nan None None
Homo sapiens Interleukin-8 receptor B Ki nan None None
Homo sapiens Jurkat CC50 100000.0 nM 10.1016/j.bmcl.2007.01.109
Homo sapiens Jurkat IC50 100000.0 nM 10.1016/j.bmcl.2006.06.066
Homo sapiens Kappa opioid receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Kappa opioid receptor IC50 nan None None
Homo sapiens Kappa opioid receptor Ki nan None None
Homo sapiens KB IC50 3500.0 nM 10.1021/jm960631x
Homo sapiens KB IC50 100000.0 nM 10.1021/jm00020a025
Homo sapiens KB IC50 100000.0 nM 10.1021/jm00020a026
Homo sapiens KB IC50 100000.0 nM 10.1021/jm00020a027
Homo sapiens KB IC50 100000.0 nM 10.1021/jm00081a014
Homo sapiens KB IC50 100000.0 nM 10.1021/jm040016q
Homo sapiens KB IC50 100000.0 nM 10.1021/jm950556a
Homo sapiens KB IC50 100000.0 nM 10.1021/jm960157v
Homo sapiens KB IC50 100000.0 nM 10.1021/jm960462g
Homo sapiens KB IC50 100000.0 nM 10.1021/jm9604888
Homo sapiens KB IC50 100000.0 nM 10.1021/jm960533b
Homo sapiens KB IC50 100000.0 nM 10.1021/jm960631x
Homo sapiens KB IC50 100000.0 nM 10.1021/jm970532z
Homo sapiens KB IC50 100000.0 nM 10.1021/jm970545c
Homo sapiens KB IC50 100000.0 nM 10.1021/jm990195p
Homo sapiens KB IC50 320000.0 nM 10.1021/jm950835y
Homo sapiens KB IC50 nan nM 10.1021/jm9705723
Homo sapiens KB IC50 nan None 10.1021/jm2001426
Homo sapiens Leukocyte common antigen IC50 nan None None
Homo sapiens Leukocyte common antigen Ki nan None None
Homo sapiens Leukocyte elastase IC50 nan None None
Homo sapiens Leukocyte elastase Ki nan None None
Homo sapiens MAP kinase ERK1 IC50 nan None None
Homo sapiens MAP kinase ERK1 Ki nan None None
Homo sapiens MAP kinase ERK2 IC50 nan None None
Homo sapiens MAP kinase ERK2 Ki nan None None
Homo sapiens MAP kinase p38 alpha IC50 nan None None
Homo sapiens MAP kinase p38 alpha Ki nan None None
Homo sapiens Matrix metalloproteinase-1 IC50 nan None None
Homo sapiens Matrix metalloproteinase-1 Ki nan None None
Homo sapiens Matrix metalloproteinase 9 IC50 nan None None
Homo sapiens Matrix metalloproteinase 9 Ki nan None None
Homo sapiens Melanocortin receptor 3 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Melanocortin receptor 3 IC50 nan None None
Homo sapiens Melanocortin receptor 3 Ki nan None None
Homo sapiens Melanocortin receptor 4 IC50 nan None None
Homo sapiens Melanocortin receptor 4 Ki nan None None
Homo sapiens Melanocortin receptor 5 IC50 nan None None
Homo sapiens Melanocortin receptor 5 Ki nan None None
Homo sapiens Menin/Histone-lysine N-methyltransferase MLL Potency 10000.0 nM None
Homo sapiens Monoamine oxidase A AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Monoamine oxidase A IC50 nan None None
Homo sapiens Monoamine oxidase A Ki nan None None
Homo sapiens Motilin receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens MRC5 CC50 100.0 ug.mL-1 10.1016/s0960-894x(98)00649-0
Homo sapiens MRC5 CC50 98000.0 nM 10.1021/jm000033p
Homo sapiens MRC5 CC50 100000.0 nM 10.1016/j.bmc.2023.117276
Homo sapiens MRC5 CC50 333000.0 nM 10.1128/aac.01596-09
Homo sapiens MRC5 CC50% 1000.0 ug ml-1 10.1016/j.bmcl.2005.01.050
Homo sapiens MRC5 CD50 125.0 uM 10.1021/jm9802057
Homo sapiens MRC5 EC50 9400.0 nM 10.1021/jm0203276
Homo sapiens MRC5 HCMV yield 2.4 pfu/ml 10.1021/jm00166a020
Homo sapiens MRC5 HCMV yield reduction 3.0 pfu/ml 10.1021/jm00166a020
Homo sapiens MRC5 IC50 1.2 ug.mL-1 10.1016/j.bmcl.2005.01.050
Homo sapiens MRC5 IC50 2.1 ug.mL-1 10.1016/s0960-894x(98)00649-0
Homo sapiens MRC5 IC50 2.2 ug.mL-1 10.1016/j.bmcl.2005.01.050
Homo sapiens MRC5 IC50 3.2 ug.mL-1 10.1021/jm00020a009
Homo sapiens MRC5 IC50 7.8 ug.mL-1 10.1016/j.bmcl.2005.01.050
Homo sapiens MRC5 IC50 8.7 ug.mL-1 10.1016/j.bmcl.2005.01.050
Homo sapiens MRC5 IC50 1400.0 nM 10.1016/s0960-894x(01)00352-3
Homo sapiens MRC5 IC50 1500.0 nM 10.1016/s0960-894x(01)00352-3
Homo sapiens MRC5 IC50 1600.0 nM 10.1016/s0960-894x(01)00352-3
Homo sapiens MRC5 IC50 1700.0 nM 10.1021/jm00035a018
Homo sapiens MRC5 IC50 3000.0 nM 10.1016/s0960-894x(01)00352-3
Homo sapiens MRC5 IC50 4000.0 nM 10.1021/jm00094a005
Homo sapiens MRC5 IC50 6300.0 nM 10.1021/jm9802057
Homo sapiens MRC5 IC50 10000.0 nM 10.1016/s0960-894x(01)00352-3
Homo sapiens MRC5 IC50 970000.0 nM 10.1016/j.bmcl.2006.12.085
Homo sapiens MRC5 IC50 nan nM 10.1016/s0960-894x(01)00352-3
Homo sapiens MRC5 ID50 5.0 uM 10.1021/jm00155a015
Homo sapiens MRC5 TC50 500.0 ug ml-1 10.1021/jm00020a009
Homo sapiens MRC5 TC50 1000.0 ug ml-1 10.1021/jm00020a009
Homo sapiens MT4 CC50 nan None 10.1016/j.bmc.2015.12.008
Homo sapiens MT4 IC50 50000.0 nM 10.1021/acs.jmedchem.7b01009
Homo sapiens Multidrug resistance-associated protein 4 IC50 133000.0 nM 10.1093/toxsci/kft176
Homo sapiens Mu opioid receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Mu opioid receptor IC50 nan None None
Homo sapiens Mu opioid receptor Ki nan None None
Homo sapiens Muscarinic acetylcholine receptor M1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Muscarinic acetylcholine receptor M1 IC50 nan None None
Homo sapiens Muscarinic acetylcholine receptor M1 Ki nan None None
Homo sapiens Muscarinic acetylcholine receptor M2 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Muscarinic acetylcholine receptor M2 IC50 nan None None
Homo sapiens Muscarinic acetylcholine receptor M2 Ki nan None None
Homo sapiens Muscarinic acetylcholine receptor M3 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Muscarinic acetylcholine receptor M3 IC50 nan None None
Homo sapiens Muscarinic acetylcholine receptor M3 Ki nan None None
Homo sapiens Muscarinic acetylcholine receptor M4 IC50 nan None None
Homo sapiens Muscarinic acetylcholine receptor M4 Ki nan None None
Homo sapiens Muscarinic acetylcholine receptor M5 IC50 nan None None
Homo sapiens Muscarinic acetylcholine receptor M5 Ki nan None None
Homo sapiens Neoplastic cell line IC50 100000.0 nM 10.1021/jm00169a028
Homo sapiens Neurokinin 1 receptor IC50 nan None None
Homo sapiens Neurokinin 1 receptor Ki nan None None
Homo sapiens Neurokinin 2 receptor IC50 nan None None
Homo sapiens Neurokinin 2 receptor Ki nan None None
Homo sapiens Neuronal acetylcholine receptor protein alpha-4 subunit AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Neuropeptide Y receptor type 1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Neuropeptide Y receptor type 1 IC50 nan None None
Homo sapiens Neuropeptide Y receptor type 1 Ki nan None None
Homo sapiens Neuropeptide Y receptor type 2 IC50 nan None None
Homo sapiens Neuropeptide Y receptor type 2 Ki nan None None
Homo sapiens NHDF CC50 333000.0 nM 10.1128/aac.01596-09
Homo sapiens Norepinephrine transporter AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Norepinephrine transporter IC50 nan None None
Homo sapiens Norepinephrine transporter Ki nan None None
Homo sapiens Nuclear factor NF-kappa-B p105 subunit Potency 10000.0 nM None
Homo sapiens Phosphodiesterase 3A AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Phosphodiesterase 4D AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Phosphodiesterase 5A IC50 nan None None
Homo sapiens Phosphodiesterase 5A Ki nan None None
Homo sapiens Platelet activating factor receptor IC50 nan None None
Homo sapiens Platelet activating factor receptor Ki nan None None
Homo sapiens POU domain, class 2, transcription factor 2 Drug transport nan None 10.1124/dmd.111.042036
Homo sapiens POU domain, class 2, transcription factor 2 Jmax 1838.0 pmol/min 10.1124/dmd.111.042036
Homo sapiens POU domain, class 2, transcription factor 2 Km 264000.0 nM 10.1124/dmd.111.042036
Homo sapiens POU domain, class 2, transcription factor 2 Ratio 7.0 uL/min 10.1124/dmd.111.042036
Homo sapiens Pregnane X receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Prelamin-A/C Potency 3162.3 nM None
Homo sapiens Progesterone receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Protein kinase C alpha IC50 nan None None
Homo sapiens Protein kinase C alpha Ki nan None None
Homo sapiens Protein kinase C (PKC) Inhibition nan % 10.1016/s0960-894x(01)00352-3
Homo sapiens Raji EC50 nan nM 10.1021/jm00069a004
Homo sapiens Receptor protein-tyrosine kinase erbB-2 IC50 nan None None
Homo sapiens Receptor protein-tyrosine kinase erbB-2 Ki nan None None
Homo sapiens Serine/threonine protein phosphatase 2B catalytic subunit, alpha isoform IC50 nan None None
Homo sapiens Serine/threonine protein phosphatase 2B catalytic subunit, alpha isoform Ki nan None None
Homo sapiens Serotonin 1a (5-HT1a) receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2a (5-HT2a) receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2a (5-HT2a) receptor IC50 nan None None
Homo sapiens Serotonin 2a (5-HT2a) receptor Ki nan None None
Homo sapiens Serotonin 2b (5-HT2b) receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2b (5-HT2b) receptor IC50 nan None None
Homo sapiens Serotonin 2b (5-HT2b) receptor Ki nan None None
Homo sapiens Serotonin 2c (5-HT2c) receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2c (5-HT2c) receptor IC50 nan None None
Homo sapiens Serotonin 2c (5-HT2c) receptor Ki nan None None
Homo sapiens Serotonin 3a (5-HT3a) receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 6 (5-HT6) receptor IC50 nan None None
Homo sapiens Serotonin 6 (5-HT6) receptor Ki nan None None
Homo sapiens Serotonin transporter AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin transporter IC50 nan None None
Homo sapiens Serotonin transporter Ki nan None None
Homo sapiens Sigma opioid receptor IC50 nan None None
Homo sapiens Sigma opioid receptor Ki nan None None
Homo sapiens Solute carrier family 22 member 1 Activity 88.3 % 10.1124/jpet.300.3.918
Homo sapiens Solute carrier family 22 member 1 Inhibition 10.5 % 10.1021/jm8003152
Homo sapiens Solute carrier family 22 member 1 Km 516200.0 nM 10.1124/jpet.300.3.918
Homo sapiens Solute carrier family 22 member 6 Activity 87.1 % 10.1124/jpet.300.3.918
Homo sapiens Solute carrier family 22 member 6 Drug transport nan None 10.1124/dmd.111.042036
Homo sapiens Solute carrier family 22 member 6 Km 895500.0 nM 10.1124/jpet.300.3.918
Homo sapiens Solute carrier family 22 member 7 Activity 63.3 % 10.1124/jpet.300.3.918
Homo sapiens Solute carrier family 22 member 7 FC 12.0 None 10.1124/dmd.111.042036
Homo sapiens Solute carrier family 22 member 8 Activity 74.3 % 10.1124/jpet.300.3.918
Homo sapiens Solute carrier family 22 member 8 Drug transport nan None 10.1124/dmd.111.042036
Homo sapiens Survival motor neuron protein Potency 1584.9 nM None
Homo sapiens Survival motor neuron protein Potency 35481.3 nM None
Homo sapiens Thromboxane A2 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Thromboxane-A synthase IC50 nan None None
Homo sapiens Thromboxane-A synthase Ki nan None None
Homo sapiens Thymidine kinase, cytosolic Activity 98.0 % 10.1021/jm00158a011
Homo sapiens Thymidine kinase, cytosolic k cat 0.1 s-1 10.1021/jm030241s
Homo sapiens Transitional endoplasmic reticulum ATPase IC50 1300.0 nM 10.1016/j.ejmech.2021.113446
Homo sapiens Type-1 angiotensin II receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Tyrosine-protein kinase FYN IC50 nan None None
Homo sapiens Tyrosine-protein kinase FYN Ki nan None None
Homo sapiens Tyrosine-protein kinase LCK IC50 nan None None
Homo sapiens Tyrosine-protein kinase LCK Ki nan None None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 1013.7 nM None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 1299.5 nM None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 1606.7 nM None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 2592.9 nM None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 3548.1 nM None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 5011.9 nM None
Homo sapiens Vascular endothelial growth factor receptor 1 IC50 nan None None
Homo sapiens Vascular endothelial growth factor receptor 1 Ki nan None None
Homo sapiens Vasoactive intestinal polypeptide receptor 1 IC50 nan None None
Homo sapiens Vasoactive intestinal polypeptide receptor 1 Ki nan None None
Homo sapiens Vasopressin V1a receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Vasopressin V1a receptor IC50 nan None None
Homo sapiens Vasopressin V1a receptor Ki nan None None
Homo sapiens Vasopressin V2 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Human adenovirus 2 Human adenovirus 2 EC50 nan None 10.1016/j.ejmech.2022.114618
Human adenovirus 2 Human adenovirus 2 IC50 35000.0 nM 10.1016/j.bmc.2008.11.075
Human alphaherpesvirus 1 Human alphaherpesvirus 1 Activity nan None 10.1016/j.ejmech.2011.11.021
Human alphaherpesvirus 1 Human alphaherpesvirus 1 Average survival 9.8 day 10.1021/jm00145a014
Human alphaherpesvirus 1 Human alphaherpesvirus 1 Average survival 12.6 day 10.1021/jm00145a014
Human alphaherpesvirus 1 Human alphaherpesvirus 1 EC50 0.00038 ug.mL-1 10.1021/jm061281+
Human alphaherpesvirus 1 Human alphaherpesvirus 1 EC50 0.002 ug.mL-1 10.1021/jm0701472
Human alphaherpesvirus 1 Human alphaherpesvirus 1 EC50 0.019 ug.mL-1 10.1021/jm025569k
Human alphaherpesvirus 1 Human alphaherpesvirus 1 EC50 0.02 ug.mL-1 10.1021/jm0701472
Human alphaherpesvirus 1 Human alphaherpesvirus 1 EC50 0.03 ug.mL-1 10.1016/j.ejmech.2010.09.065
Human alphaherpesvirus 1 Human alphaherpesvirus 1 EC50 0.05 ug.mL-1 10.1016/j.ejmech.2010.07.058
Human alphaherpesvirus 1 Human alphaherpesvirus 1 EC50 0.06 ug.mL-1 10.1016/j.ejmech.2008.08.010
Human alphaherpesvirus 1 Human alphaherpesvirus 1 EC50 0.08 ug.mL-1 10.1016/j.ejmech.2009.03.038
Human alphaherpesvirus 1 Human alphaherpesvirus 1 EC50 0.7 ug.mL-1 10.1021/jm0701472
Human alphaherpesvirus 1 Human alphaherpesvirus 1 EC50 0.91 ug.mL-1 10.1021/jm061281+
Human alphaherpesvirus 1 Human alphaherpesvirus 1 EC50 1.0 ug.mL-1 10.1016/j.ejmech.2008.08.010
Human alphaherpesvirus 1 Human alphaherpesvirus 1 EC50 2.0 ug.mL-1 10.1016/j.ejmech.2010.07.058
Human alphaherpesvirus 1 Human alphaherpesvirus 1 EC50 6.0 ug.mL-1 10.1016/j.ejmech.2009.03.038
Human alphaherpesvirus 1 Human alphaherpesvirus 1 EC50 10.0 nM 10.1016/j.bmcl.2018.09.019
Human alphaherpesvirus 1 Human alphaherpesvirus 1 EC50 10.0 nM 10.1016/j.ejmech.2010.12.017
Human alphaherpesvirus 1 Human alphaherpesvirus 1 EC50 10.0 nM 10.1021/ml2001054
Human alphaherpesvirus 1 Human alphaherpesvirus 1 EC50 15.0 nM 10.1016/j.bmcl.2012.09.079
Human alphaherpesvirus 1 Human alphaherpesvirus 1 EC50 17.0 nM 10.1016/j.bmc.2011.06.045
Human alphaherpesvirus 1 Human alphaherpesvirus 1 EC50 19.0 nM 10.1021/jm060030y
Human alphaherpesvirus 1 Human alphaherpesvirus 1 EC50 20.0 nM 10.1016/j.bmc.2015.04.079
Human alphaherpesvirus 1 Human alphaherpesvirus 1 EC50 20.0 nM 10.1016/j.bmc.2018.05.034
Human alphaherpesvirus 1 Human alphaherpesvirus 1 EC50 20.0 nM 10.1016/j.ejmech.2012.03.007
Human alphaherpesvirus 1 Human alphaherpesvirus 1 EC50 20.0 nM 10.1016/j.ejmech.2022.114618
Human alphaherpesvirus 1 Human alphaherpesvirus 1 EC50 20.0 nM 10.1021/jm801470b
Human alphaherpesvirus 1 Human alphaherpesvirus 1 EC50 25.0 nM 10.1016/j.ejmech.2020.112790
Human alphaherpesvirus 1 Human alphaherpesvirus 1 EC50 25.0 nM 10.1021/acs.jnatprod.9b00545
Human alphaherpesvirus 1 Human alphaherpesvirus 1 EC50 27.0 nM 10.1016/j.ejmech.2012.07.027
Human alphaherpesvirus 1 Human alphaherpesvirus 1 EC50 30.0 nM 10.1016/j.bmc.2011.04.016
Human alphaherpesvirus 1 Human alphaherpesvirus 1 EC50 30.0 nM 10.1016/j.bmc.2011.05.037
Human alphaherpesvirus 1 Human alphaherpesvirus 1 EC50 30.0 nM 10.1016/j.ejmech.2009.12.002
Human alphaherpesvirus 1 Human alphaherpesvirus 1 EC50 30.0 nM 10.1016/j.ejmech.2013.05.046
Human alphaherpesvirus 1 Human alphaherpesvirus 1 EC50 30.0 nM 10.1016/j.ejmech.2018.07.062
Human alphaherpesvirus 1 Human alphaherpesvirus 1 EC50 30.0 nM 10.1021/acs.jmedchem.7b01009
Human alphaherpesvirus 1 Human alphaherpesvirus 1 EC50 32.0 nM 10.1016/j.ejmech.2016.10.002
Human alphaherpesvirus 1 Human alphaherpesvirus 1 EC50 40.0 nM 10.1016/j.bmc.2017.06.046
Human alphaherpesvirus 1 Human alphaherpesvirus 1 EC50 40.0 nM 10.1021/acs.jmedchem.9b01501
Human alphaherpesvirus 1 Human alphaherpesvirus 1 EC50 45.0 nM 10.1016/j.ejmech.2018.03.008
Human alphaherpesvirus 1 Human alphaherpesvirus 1 EC50 57.0 nM 10.1021/acsmedchemlett.8b00079
Human alphaherpesvirus 1 Human alphaherpesvirus 1 EC50 58.0 ug.mL-1 10.1016/j.ejmech.2010.09.065
Human alphaherpesvirus 1 Human alphaherpesvirus 1 EC50 60.0 nM 10.1021/jm0493966
Human alphaherpesvirus 1 Human alphaherpesvirus 1 EC50 60.0 nM 10.1021/jm0504306
Human alphaherpesvirus 1 Human alphaherpesvirus 1 EC50 70.0 nM 10.1016/j.bmc.2019.02.005
Human alphaherpesvirus 1 Human alphaherpesvirus 1 EC50 70.0 nM 10.1016/j.ejmech.2019.111739
Human alphaherpesvirus 1 Human alphaherpesvirus 1 EC50 80.0 nM 10.1007/s00044-009-9248-y
Human alphaherpesvirus 1 Human alphaherpesvirus 1 EC50 80.0 nM 10.1021/jm1011462
Human alphaherpesvirus 1 Human alphaherpesvirus 1 EC50 90.0 nM 10.1007/s00044-012-0184-x
Human alphaherpesvirus 1 Human alphaherpesvirus 1 EC50 90.0 nM 10.1016/j.ejmech.2016.09.014
Human alphaherpesvirus 1 Human alphaherpesvirus 1 EC50 100.0 nM 10.1016/j.bmc.2017.06.046
Human alphaherpesvirus 1 Human alphaherpesvirus 1 EC50 100.0 nM 10.1016/j.bmcl.2021.128405
Human alphaherpesvirus 1 Human alphaherpesvirus 1 EC50 100.0 nM 10.1016/j.ejmech.2010.12.017
Human alphaherpesvirus 1 Human alphaherpesvirus 1 EC50 120.0 nM 10.1016/j.bmc.2011.06.045
Human alphaherpesvirus 1 Human alphaherpesvirus 1 EC50 200.0 nM 10.1016/j.bmcl.2018.09.019
Human alphaherpesvirus 1 Human alphaherpesvirus 1 EC50 480.0 nM 10.1021/jm060030y
Human alphaherpesvirus 1 Human alphaherpesvirus 1 EC50 500.0 nM 10.1016/j.bmc.2015.04.079
Human alphaherpesvirus 1 Human alphaherpesvirus 1 EC50 500.0 nM 10.1016/j.ejmech.2018.07.062
Human alphaherpesvirus 1 Human alphaherpesvirus 1 EC50 700.0 nM 10.1128/aac.01284-06
Human alphaherpesvirus 1 Human alphaherpesvirus 1 EC50 800.0 nM 10.1016/j.bmc.2011.05.037
Human alphaherpesvirus 1 Human alphaherpesvirus 1 EC50 800.0 nM 10.1016/j.bmc.2018.05.034
Human alphaherpesvirus 1 Human alphaherpesvirus 1 EC50 800.0 nM 10.1016/j.bmc.2019.02.005
Human alphaherpesvirus 1 Human alphaherpesvirus 1 EC50 800.0 nM 10.1016/j.ejmech.2019.111739
Human alphaherpesvirus 1 Human alphaherpesvirus 1 EC50 800.0 nM 10.1016/j.ejmech.2022.114618
Human alphaherpesvirus 1 Human alphaherpesvirus 1 EC50 900.0 nM 10.1021/acs.jmedchem.5b00804
Human alphaherpesvirus 1 Human alphaherpesvirus 1 EC50 1000.0 nM 10.1021/ml2001054
Human alphaherpesvirus 1 Human alphaherpesvirus 1 EC50 1500.0 nM 10.1016/j.ejmech.2006.11.002
Human alphaherpesvirus 1 Human alphaherpesvirus 1 EC50 3000.0 nM 10.1021/jm1011462
Human alphaherpesvirus 1 Human alphaherpesvirus 1 EC50 3910.0 nM 10.1016/j.ejmech.2018.03.008
Human alphaherpesvirus 1 Human alphaherpesvirus 1 EC50 4000.0 nM 10.1016/j.bmcl.2012.09.079
Human alphaherpesvirus 1 Human alphaherpesvirus 1 EC50 4000.0 nM 10.1016/j.ejmech.2013.05.046
Human alphaherpesvirus 1 Human alphaherpesvirus 1 EC50 4000.0 nM 10.1016/j.ejmech.2016.10.002
Human alphaherpesvirus 1 Human alphaherpesvirus 1 EC50 4300.0 nM 10.1021/acs.jmedchem.7b01009
Human alphaherpesvirus 1 Human alphaherpesvirus 1 EC50 6000.0 nM 10.1007/s00044-009-9248-y
Human alphaherpesvirus 1 Human alphaherpesvirus 1 EC50 9000.0 nM 10.1021/jm801470b
Human alphaherpesvirus 1 Human alphaherpesvirus 1 EC50 14700.0 nM 10.1016/j.ejmech.2012.07.027
Human alphaherpesvirus 1 Human alphaherpesvirus 1 EC50 15700.0 nM 10.1016/j.bmc.2011.04.016
Human alphaherpesvirus 1 Human alphaherpesvirus 1 EC50 19300.0 nM 10.1128/aac.01435-08
Human alphaherpesvirus 1 Human alphaherpesvirus 1 EC50 20000.0 nM 10.1007/s00044-012-0184-x
Human alphaherpesvirus 1 Human alphaherpesvirus 1 EC50 29500.0 nM 10.1021/acsmedchemlett.8b00079
Human alphaherpesvirus 1 Human alphaherpesvirus 1 EC50 100000.0 nM 10.1016/j.ejmech.2012.03.007
Human alphaherpesvirus 1 Human alphaherpesvirus 1 EC50 100000.0 nM 10.1016/j.ejmech.2013.06.036
Human alphaherpesvirus 1 Human alphaherpesvirus 1 EC50 100000.0 nM 10.1016/j.ejmech.2016.09.014
Human alphaherpesvirus 1 Human alphaherpesvirus 1 EC50 nan nM 10.1016/s0960-894x(01)00735-1
Human alphaherpesvirus 1 Human alphaherpesvirus 1 EC50 nan ug.mL-1 10.1016/s0960-894x(98)00122-x
Human alphaherpesvirus 1 Human alphaherpesvirus 1 ED50 0.016 ug ml-1 10.1021/jm9701536
Human alphaherpesvirus 1 Human alphaherpesvirus 1 ED50 1.0 ug ml-1 10.1021/jm00145a014
Human alphaherpesvirus 1 Human alphaherpesvirus 1 ED50 1.0 uM 10.1021/jm00117a021
Human alphaherpesvirus 1 Human alphaherpesvirus 1 IC50 0.001 ug.mL-1 10.1016/s0960-894x(01)00270-0
Human alphaherpesvirus 1 Human alphaherpesvirus 1 IC50 0.48 ug.mL-1 10.1016/s0960-894x(01)00270-0
Human alphaherpesvirus 1 Human alphaherpesvirus 1 IC50 100.0 nM 10.1021/jm00396a021
Human alphaherpesvirus 1 Human alphaherpesvirus 1 IC50 1200.0 nM 10.1021/jm00169a028
Human alphaherpesvirus 1 Human alphaherpesvirus 1 IC50 1800.0 nM 10.1021/jm970532z
Human alphaherpesvirus 1 Human alphaherpesvirus 1 IC50 2300.0 nM 10.1021/jm00127a003
Human alphaherpesvirus 1 Human alphaherpesvirus 1 IC50 2300.0 nM 10.1021/jm00169a027
Human alphaherpesvirus 1 Human alphaherpesvirus 1 IC50 3000.0 nM 10.1021/jm00119a006
Human alphaherpesvirus 1 Human alphaherpesvirus 1 IC50 3000.0 nM 10.1021/jm00403a005
Human alphaherpesvirus 1 Human alphaherpesvirus 1 IC50 3000.0 nM 10.1021/jm950835y
Human alphaherpesvirus 1 Human alphaherpesvirus 1 IC50 3500.0 nM 10.1016/S0960-894X(00)80628-9
Human alphaherpesvirus 1 Human alphaherpesvirus 1 IC50 3500.0 nM 10.1021/jm00020a025
Human alphaherpesvirus 1 Human alphaherpesvirus 1 IC50 3500.0 nM 10.1021/jm00020a026
Human alphaherpesvirus 1 Human alphaherpesvirus 1 IC50 3500.0 nM 10.1021/jm00020a027
Human alphaherpesvirus 1 Human alphaherpesvirus 1 IC50 3500.0 nM 10.1021/jm00044a015
Human alphaherpesvirus 1 Human alphaherpesvirus 1 IC50 3500.0 nM 10.1021/jm00076a011
Human alphaherpesvirus 1 Human alphaherpesvirus 1 IC50 3500.0 nM 10.1021/jm0400146
Human alphaherpesvirus 1 Human alphaherpesvirus 1 IC50 3500.0 nM 10.1021/jm040016q
Human alphaherpesvirus 1 Human alphaherpesvirus 1 IC50 3500.0 nM 10.1021/jm950556a
Human alphaherpesvirus 1 Human alphaherpesvirus 1 IC50 3500.0 nM 10.1021/jm960157v
Human alphaherpesvirus 1 Human alphaherpesvirus 1 IC50 3500.0 nM 10.1021/jm960462g
Human alphaherpesvirus 1 Human alphaherpesvirus 1 IC50 3500.0 nM 10.1021/jm9604888
Human alphaherpesvirus 1 Human alphaherpesvirus 1 IC50 3500.0 nM 10.1021/jm960533b
Human alphaherpesvirus 1 Human alphaherpesvirus 1 IC50 3500.0 nM 10.1021/jm970545c
Human alphaherpesvirus 1 Human alphaherpesvirus 1 IC50 3500.0 nM 10.1021/jm990195p
Human alphaherpesvirus 1 Human alphaherpesvirus 1 IC50 3500.0 nM 10.1021/jm990219s
Human alphaherpesvirus 1 Human alphaherpesvirus 1 IC50 3500.0 nM 10.1021/jm990290y
Human alphaherpesvirus 1 Human alphaherpesvirus 1 IC50 4500.0 nM 10.1021/jm00081a014
Human alphaherpesvirus 1 Human alphaherpesvirus 1 IC50 4500.0 nM 10.1021/jm00169a028
Human alphaherpesvirus 1 Human alphaherpesvirus 1 IC50 4500.0 nM 10.1021/jm00174a011
Human alphaherpesvirus 1 Human alphaherpesvirus 1 IC50 nan None 10.1016/j.bmc.2008.10.081
Human alphaherpesvirus 1 Human alphaherpesvirus 1 IC50 nan None 10.1016/j.bmcl.2007.03.102
Human alphaherpesvirus 1 Human alphaherpesvirus 1 IC50 nan None 10.1016/j.bmcl.2007.05.010
Human alphaherpesvirus 1 Human alphaherpesvirus 1 IC50 nan None 10.1016/j.bmcl.2008.06.060
Human alphaherpesvirus 1 Human alphaherpesvirus 1 IC50 nan None 10.1016/j.bmcl.2010.03.115
Human alphaherpesvirus 1 Human alphaherpesvirus 1 IC50 nan None 10.1021/jm2001426
Human alphaherpesvirus 1 Human alphaherpesvirus 1 IC90 1200.0 nM 10.1021/jm00174a011
Human alphaherpesvirus 1 Human alphaherpesvirus 1 ID50 0.04 uM 10.1021/jm00108a026
Human alphaherpesvirus 1 Human alphaherpesvirus 1 ID50 0.2 ug ml-1 10.1021/jm00168a039
Human alphaherpesvirus 1 Human alphaherpesvirus 1 ID50 0.23 ug ml-1 10.1021/jm00127a010
Human alphaherpesvirus 1 Human alphaherpesvirus 1 ID50 0.3 uM 10.1021/jm00147a020
Human alphaherpesvirus 1 Human alphaherpesvirus 1 ID50 10.0 ug ml-1 10.1021/jm00127a010
Human alphaherpesvirus 1 Human alphaherpesvirus 1 Inhibition 55.0 % 10.1021/jm00145a014
Human alphaherpesvirus 1 Human alphaherpesvirus 1 Inhibition 60.0 % 10.1021/jm00155a039
Human alphaherpesvirus 1 Human alphaherpesvirus 1 Inhibition nan % 10.1021/acs.jnatprod.9b00545
Human alphaherpesvirus 1 Human alphaherpesvirus 1 MIC 0.0007 ug.mL-1 10.1016/S0960-894X(96)00244-2
Human alphaherpesvirus 1 Human alphaherpesvirus 1 MIC 0.001 ug.mL-1 10.1021/jm00066a013
Human alphaherpesvirus 1 Human alphaherpesvirus 1 MIC 0.001 ug.mL-1 10.1021/jm991171l
Human alphaherpesvirus 1 Human alphaherpesvirus 1 MIC 0.002 ug.mL-1 10.1021/jm991171l
Human alphaherpesvirus 1 Human alphaherpesvirus 1 MIC 0.004 ug.mL-1 10.1021/jm00045a025
Human alphaherpesvirus 1 Human alphaherpesvirus 1 MIC 0.004 ug.mL-1 10.1021/jm00066a013
Human alphaherpesvirus 1 Human alphaherpesvirus 1 MIC 0.004 ug.mL-1 10.1021/jm010922s
Human alphaherpesvirus 1 Human alphaherpesvirus 1 MIC 0.006 ug.mL-1 10.1021/jm010922s
Human alphaherpesvirus 1 Human alphaherpesvirus 1 MIC 0.007 ug.mL-1 10.1021/jm00066a013
Human alphaherpesvirus 1 Human alphaherpesvirus 1 MIC 0.032 ug.mL-1 10.1016/j.ejmech.2007.04.010
Human alphaherpesvirus 1 Human alphaherpesvirus 1 MIC 0.07 ug.mL-1 10.1021/jm010922s
Human alphaherpesvirus 1 Human alphaherpesvirus 1 MIC 0.08 ug.mL-1 10.1021/jm00045a025
Human alphaherpesvirus 1 Human alphaherpesvirus 1 MIC 0.1 ug.mL-1 10.1021/jm00167a019
Human alphaherpesvirus 1 Human alphaherpesvirus 1 MIC 0.2 ug.mL-1 10.1021/jm00167a019
Human alphaherpesvirus 1 Human alphaherpesvirus 1 MIC 0.48 ug.mL-1 10.1007/s00044-012-0127-6
Human alphaherpesvirus 1 Human alphaherpesvirus 1 MIC 0.48 ug.mL-1 10.1021/jm010922s
Human alphaherpesvirus 1 Human alphaherpesvirus 1 MIC 2.0 ug.mL-1 10.1021/jm00066a013
Human alphaherpesvirus 1 Human alphaherpesvirus 1 MIC 2.4 ug.mL-1 10.1016/j.ejmech.2007.04.010
Human alphaherpesvirus 1 Human alphaherpesvirus 1 MIC 4.5 ug.mL-1 10.1021/jm00045a025
Human alphaherpesvirus 1 Human alphaherpesvirus 1 MIC 10.0 ug.mL-1 10.1021/jm00167a019
Human alphaherpesvirus 1 Human alphaherpesvirus 1 MIC 12.0 ug.mL-1 10.1007/s00044-012-0127-6
Human alphaherpesvirus 1 Human alphaherpesvirus 1 MIC 20.0 ug.mL-1 10.1021/jm00167a019
Human alphaherpesvirus 1 Human alphaherpesvirus 1 MIC 32.0 nM 10.1021/jm070324z
Human alphaherpesvirus 1 Human alphaherpesvirus 1 MIC 96.0 nM 10.1016/j.bmc.2006.10.046
Human alphaherpesvirus 1 Human alphaherpesvirus 1 MIC 800.0 nM 10.1016/j.bmc.2006.10.046
Human alphaherpesvirus 1 Human alphaherpesvirus 1 MIC50 0.02 ug.mL-1 10.1021/jm950891z
Human alphaherpesvirus 1 Human alphaherpesvirus 1 MIC50 0.032 ug.mL-1 10.1016/j.ejmech.2009.02.030
Human alphaherpesvirus 1 Human alphaherpesvirus 1 MIC50 0.096 ug.mL-1 10.1021/jm050772b
Human alphaherpesvirus 1 Human alphaherpesvirus 1 MIC50 0.48 ug.mL-1 10.1021/jm050772b
Human alphaherpesvirus 1 Human alphaherpesvirus 1 MIC50 2.4 ug.mL-1 10.1016/j.ejmech.2009.02.030
Human alphaherpesvirus 1 Human alphaherpesvirus 1 MIC50 200.0 ug.mL-1 10.1021/jm950891z
Human alphaherpesvirus 1 Human alphaherpesvirus 1 Survivors 3.0 None 10.1021/jm00145a014
Human alphaherpesvirus 1 Human alphaherpesvirus 1 Survivors 5.0 None 10.1021/jm00145a014
Human alphaherpesvirus 1 Human alphaherpesvirus 1 Survivors 7.0 None 10.1021/jm00145a014
Human alphaherpesvirus 1 Human alphaherpesvirus 1 VR 1.4 None 10.1021/jm00117a021
Human alphaherpesvirus 2 Human alphaherpesvirus 2 Activity nan None 10.1016/j.ejmech.2011.11.021
Human alphaherpesvirus 2 Human alphaherpesvirus 2 EC50 0.0014 ug.mL-1 10.1021/jm061281+
Human alphaherpesvirus 2 Human alphaherpesvirus 2 EC50 0.0014 ug.mL-1 10.1021/jm0707166
Human alphaherpesvirus 2 Human alphaherpesvirus 2 EC50 0.0036 ug.mL-1 10.1021/jm0707166
Human alphaherpesvirus 2 Human alphaherpesvirus 2 EC50 0.007 ug.mL-1 10.1021/jm0701472
Human alphaherpesvirus 2 Human alphaherpesvirus 2 EC50 0.0096 ug.mL-1 10.1021/jm061281+
Human alphaherpesvirus 2 Human alphaherpesvirus 2 EC50 0.03 ug.mL-1 10.1016/j.ejmech.2010.09.065
Human alphaherpesvirus 2 Human alphaherpesvirus 2 EC50 0.06 ug.mL-1 10.1016/j.ejmech.2008.08.010
Human alphaherpesvirus 2 Human alphaherpesvirus 2 EC50 0.07 ug.mL-1 10.1016/j.ejmech.2010.07.058
Human alphaherpesvirus 2 Human alphaherpesvirus 2 EC50 0.08 ug.mL-1 10.1016/j.ejmech.2009.03.038
Human alphaherpesvirus 2 Human alphaherpesvirus 2 EC50 10.0 nM 10.1016/j.bmcl.2018.09.019
Human alphaherpesvirus 2 Human alphaherpesvirus 2 EC50 10.0 nM 10.1021/ml2001054
Human alphaherpesvirus 2 Human alphaherpesvirus 2 EC50 13.0 nM 10.1016/j.bmcl.2012.09.079
Human alphaherpesvirus 2 Human alphaherpesvirus 2 EC50 19.0 nM 10.1016/j.ejmech.2018.03.008
Human alphaherpesvirus 2 Human alphaherpesvirus 2 EC50 20.0 nM 10.1016/j.bmc.2018.05.034
Human alphaherpesvirus 2 Human alphaherpesvirus 2 EC50 20.0 nM 10.1016/j.ejmech.2022.114618
Human alphaherpesvirus 2 Human alphaherpesvirus 2 EC50 23.0 nM 10.1016/j.bmc.2011.06.045
Human alphaherpesvirus 2 Human alphaherpesvirus 2 EC50 27.0 nM 10.1016/j.bmc.2011.04.016
Human alphaherpesvirus 2 Human alphaherpesvirus 2 EC50 29.0 nM 10.1016/j.ejmech.2012.07.027
Human alphaherpesvirus 2 Human alphaherpesvirus 2 EC50 30.0 nM 10.1016/j.bmc.2011.05.037
Human alphaherpesvirus 2 Human alphaherpesvirus 2 EC50 30.0 nM 10.1016/j.bmc.2015.04.079
Human alphaherpesvirus 2 Human alphaherpesvirus 2 EC50 30.0 nM 10.1016/j.bmc.2017.06.046
Human alphaherpesvirus 2 Human alphaherpesvirus 2 EC50 30.0 nM 10.1016/j.ejmech.2009.12.002
Human alphaherpesvirus 2 Human alphaherpesvirus 2 EC50 30.0 nM 10.1016/j.ejmech.2012.03.007
Human alphaherpesvirus 2 Human alphaherpesvirus 2 EC50 30.0 nM 10.1016/j.ejmech.2013.05.046
Human alphaherpesvirus 2 Human alphaherpesvirus 2 EC50 30.0 nM 10.1016/j.ejmech.2016.09.014
Human alphaherpesvirus 2 Human alphaherpesvirus 2 EC50 30.0 nM 10.1016/j.ejmech.2018.07.062
Human alphaherpesvirus 2 Human alphaherpesvirus 2 EC50 32.0 nM 10.1021/jm060030y
Human alphaherpesvirus 2 Human alphaherpesvirus 2 EC50 40.0 nM 10.1016/j.ejmech.2010.12.017
Human alphaherpesvirus 2 Human alphaherpesvirus 2 EC50 40.0 nM 10.1021/acs.jmedchem.7b01009
Human alphaherpesvirus 2 Human alphaherpesvirus 2 EC50 50.0 nM 10.1021/jm1011462
Human alphaherpesvirus 2 Human alphaherpesvirus 2 EC50 51.0 nM 10.1021/acsmedchemlett.8b00079
Human alphaherpesvirus 2 Human alphaherpesvirus 2 EC50 55.0 nM 10.1016/j.ejmech.2016.10.002
Human alphaherpesvirus 2 Human alphaherpesvirus 2 EC50 60.0 nM 10.1021/jm0504306
Human alphaherpesvirus 2 Human alphaherpesvirus 2 EC50 70.0 nM 10.1007/s00044-012-0184-x
Human alphaherpesvirus 2 Human alphaherpesvirus 2 EC50 80.0 nM 10.1007/s00044-009-9248-y
Human alphaherpesvirus 2 Human alphaherpesvirus 2 EC50 200.0 nM 10.1021/jm801470b
Human alphaherpesvirus 2 Human alphaherpesvirus 2 EC50 230.0 nM 10.1021/jm010226s
Human alphaherpesvirus 2 Human alphaherpesvirus 2 EC50 300.0 nM 10.1016/j.ejmech.2019.111739
Human alphaherpesvirus 2 Human alphaherpesvirus 2 EC50 400.0 nM 10.1016/j.bmc.2019.02.005
Human alphaherpesvirus 2 Human alphaherpesvirus 2 EC50 580.0 nM 10.1021/acs.jmedchem.9b01501
Human alphaherpesvirus 2 Human alphaherpesvirus 2 EC50 900.0 nM 10.1016/j.ejmech.2013.06.036
Human alphaherpesvirus 2 Human alphaherpesvirus 2 EC50 1400.0 nM 10.1021/acs.jmedchem.5b00804
Human alphaherpesvirus 2 Human alphaherpesvirus 2 EC50 1500.0 nM 10.1016/j.ejmech.2006.11.002
Human alphaherpesvirus 2 Human alphaherpesvirus 2 EC50 19300.0 nM 10.1128/aac.01435-08
Human alphaherpesvirus 2 Human alphaherpesvirus 2 EC50 50000.0 nM 10.1021/jm040093l
Human alphaherpesvirus 2 Human alphaherpesvirus 2 EC50 nan nM 10.1016/s0960-894x(01)00735-1
Human alphaherpesvirus 2 Human alphaherpesvirus 2 EC50 nan ug.mL-1 10.1016/s0960-894x(98)00122-x
Human alphaherpesvirus 2 Human alphaherpesvirus 2 ED50 0.039 ug ml-1 10.1021/jm9701536
Human alphaherpesvirus 2 Human alphaherpesvirus 2 ED50 1.0 uM 10.1021/jm00117a021
Human alphaherpesvirus 2 Human alphaherpesvirus 2 ED50 3.0 ug ml-1 10.1021/jm00145a014
Human alphaherpesvirus 2 Human alphaherpesvirus 2 IC50 0.002 ug.mL-1 10.1016/s0960-894x(01)00270-0
Human alphaherpesvirus 2 Human alphaherpesvirus 2 IC50 100.0 nM 10.1021/jm00396a021
Human alphaherpesvirus 2 Human alphaherpesvirus 2 IC50 32000.0 nM 10.1021/jm00170a019
Human alphaherpesvirus 2 Human alphaherpesvirus 2 ID50 0.04 uM 10.1021/jm00108a026
Human alphaherpesvirus 2 Human alphaherpesvirus 2 ID50 0.94 ug ml-1 10.1021/jm00127a010
Human alphaherpesvirus 2 Human alphaherpesvirus 2 ID50 1.3 uM 10.1021/jm00147a020
Human alphaherpesvirus 2 Human alphaherpesvirus 2 ID50 1.6 ug ml-1 10.1021/jm00168a039
Human alphaherpesvirus 2 Human alphaherpesvirus 2 Inhibition 13.0 % 10.1021/jm00145a014
Human alphaherpesvirus 2 Human alphaherpesvirus 2 MIC 0.002 ug.mL-1 10.1016/S0960-894X(96)00244-2
Human alphaherpesvirus 2 Human alphaherpesvirus 2 MIC 0.004 ug.mL-1 10.1021/jm00066a013
Human alphaherpesvirus 2 Human alphaherpesvirus 2 MIC 0.01 ug.mL-1 10.1021/jm010922s
Human alphaherpesvirus 2 Human alphaherpesvirus 2 MIC 0.02 ug.mL-1 10.1021/jm00066a013
Human alphaherpesvirus 2 Human alphaherpesvirus 2 MIC 0.02 ug.mL-1 10.1021/jm00167a019
Human alphaherpesvirus 2 Human alphaherpesvirus 2 MIC 0.02 ug.mL-1 10.1021/jm010922s
Human alphaherpesvirus 2 Human alphaherpesvirus 2 MIC 0.032 ug.mL-1 10.1016/j.ejmech.2007.04.010
Human alphaherpesvirus 2 Human alphaherpesvirus 2 MIC 0.04 ug.mL-1 10.1021/jm010922s
Human alphaherpesvirus 2 Human alphaherpesvirus 2 MIC 0.07 ug.mL-1 10.1021/jm00167a019
Human alphaherpesvirus 2 Human alphaherpesvirus 2 MIC 0.1 ug.mL-1 10.1021/jm00167a019
Human alphaherpesvirus 2 Human alphaherpesvirus 2 MIC 4.0 ug.mL-1 10.1007/s00044-012-0127-6
Human alphaherpesvirus 2 Human alphaherpesvirus 2 MIC 6.4 nM 10.1021/jm070324z
Human alphaherpesvirus 2 Human alphaherpesvirus 2 MIC 96.0 nM 10.1016/j.bmc.2006.10.046
Human alphaherpesvirus 2 Human alphaherpesvirus 2 MIC50 0.002 ug.mL-1 10.1021/jm950891z
Human alphaherpesvirus 2 Human alphaherpesvirus 2 MIC50 0.0064 ug.mL-1 10.1016/j.ejmech.2009.02.030
Human alphaherpesvirus 2 Human alphaherpesvirus 2 MIC50 0.032 ug.mL-1 10.1021/jm050772b
Human alphaherpesvirus 2 Human alphaherpesvirus 2 VR 1.6 None 10.1021/jm00117a021
Human alphaherpesvirus 3 Human alphaherpesvirus 3 Activity nan None 10.1016/j.ejmech.2011.11.021
Human alphaherpesvirus 3 Human alphaherpesvirus 3 EC50 1.0 ug.mL-1 10.1016/j.ejmech.2009.02.030
Human alphaherpesvirus 3 Human alphaherpesvirus 3 EC50 15.0 ug.mL-1 10.1016/j.ejmech.2009.02.030
Human alphaherpesvirus 3 Human alphaherpesvirus 3 EC50 26.7 ug.mL-1 10.1021/np9703914
Human alphaherpesvirus 3 Human alphaherpesvirus 3 EC50 590.0 nM 10.1016/j.ejmech.2009.03.005
Human alphaherpesvirus 3 Human alphaherpesvirus 3 EC50 1100.0 nM 10.1016/j.ejmech.2009.03.005
Human alphaherpesvirus 3 Human alphaherpesvirus 3 EC50 2300.0 nM 10.1021/jm070210n
Human alphaherpesvirus 3 Human alphaherpesvirus 3 EC50 2500.0 nM 10.1016/j.ejmech.2009.03.005
Human alphaherpesvirus 3 Human alphaherpesvirus 3 EC50 11100.0 nM 10.1021/acs.jmedchem.5b00804
Human alphaherpesvirus 3 Human alphaherpesvirus 3 EC50 nan nM 10.1016/s0960-894x(01)00735-1
Human alphaherpesvirus 3 Human alphaherpesvirus 3 EC50 nan ug.mL-1 10.1021/jm040869i
Human alphaherpesvirus 3 Human alphaherpesvirus 3 EC50 nan None 10.1016/j.bmc.2007.03.061
Human alphaherpesvirus 3 Human alphaherpesvirus 3 EC50 nan None 10.1016/j.bmc.2008.09.027
Human alphaherpesvirus 3 Human alphaherpesvirus 3 EC50 nan None 10.1016/j.bmc.2011.04.016
Human alphaherpesvirus 3 Human alphaherpesvirus 3 EC50 nan None 10.1016/j.bmc.2011.06.045
Human alphaherpesvirus 3 Human alphaherpesvirus 3 EC50 nan None 10.1016/j.bmc.2017.06.046
Human alphaherpesvirus 3 Human alphaherpesvirus 3 EC50 nan None 10.1016/j.bmc.2019.02.005
Human alphaherpesvirus 3 Human alphaherpesvirus 3 EC50 nan None 10.1016/j.ejmech.2011.02.014
Human alphaherpesvirus 3 Human alphaherpesvirus 3 EC50 nan None 10.1016/j.ejmech.2012.07.027
Human alphaherpesvirus 3 Human alphaherpesvirus 3 EC50 nan None 10.1016/j.ejmech.2018.01.086
Human alphaherpesvirus 3 Human alphaherpesvirus 3 EC50 nan None 10.1016/j.ejmech.2018.03.008
Human alphaherpesvirus 3 Human alphaherpesvirus 3 EC50 nan None 10.1016/j.ejmech.2018.07.062
Human alphaherpesvirus 3 Human alphaherpesvirus 3 EC50 nan None 10.1016/j.ejmech.2022.114618
Human alphaherpesvirus 3 Human alphaherpesvirus 3 EC50 nan None 10.1016/j.ejmech.2022.114857
Human alphaherpesvirus 3 Human alphaherpesvirus 3 EC50 nan None 10.1021/acs.jmedchem.2c00667
Human alphaherpesvirus 3 Human alphaherpesvirus 3 EC50 nan None 10.1021/acs.jmedchem.7b00416
Human alphaherpesvirus 3 Human alphaherpesvirus 3 EC50 nan None 10.1021/acs.jmedchem.7b01009
Human alphaherpesvirus 3 Human alphaherpesvirus 3 EC50 nan None 10.1021/acsmedchemlett.0c00090
Human alphaherpesvirus 3 Human alphaherpesvirus 3 EC50 nan None 10.1021/acsmedchemlett.0c00485
Human alphaherpesvirus 3 Human alphaherpesvirus 3 EC50 nan None 10.1021/acsmedchemlett.8b00079
Human alphaherpesvirus 3 Human alphaherpesvirus 3 EC50 nan None 10.1021/jm050867d
Human alphaherpesvirus 3 Human alphaherpesvirus 3 EC50 nan None 10.1021/jm070210n
Human alphaherpesvirus 3 Human alphaherpesvirus 3 EC50 nan None 10.1039/d1md00086a
Human alphaherpesvirus 3 Human alphaherpesvirus 3 EC90 nan None 10.1016/j.ejmech.2011.02.014
Human alphaherpesvirus 3 Human alphaherpesvirus 3 EC90 nan None 10.1021/acs.jmedchem.2c00667
Human alphaherpesvirus 3 Human alphaherpesvirus 3 EC90 nan None 10.1039/d1md00086a
Human alphaherpesvirus 3 Human alphaherpesvirus 3 ED50 0.21 ug ml-1 10.1021/jm9701536
Human alphaherpesvirus 3 Human alphaherpesvirus 3 ED50 1.0 ug ml-1 10.1021/jm00145a014
Human alphaherpesvirus 3 Human alphaherpesvirus 3 IC50 2800.0 nM 10.1021/jm00396a021
Human alphaherpesvirus 3 Human alphaherpesvirus 3 IC50 nan ug.mL-1 10.1016/s0960-894x(01)00270-0
Human alphaherpesvirus 3 Human alphaherpesvirus 3 IC50 nan ug.mL-1 10.1016/s0960-894x(02)00535-8
Human alphaherpesvirus 3 Human alphaherpesvirus 3 IC50 nan None 10.1016/j.bmcl.2007.03.102
Human alphaherpesvirus 3 Human alphaherpesvirus 3 IC50 nan None 10.1016/j.bmcl.2007.05.010
Human alphaherpesvirus 3 Human alphaherpesvirus 3 IC50 nan None 10.1016/j.bmcl.2008.06.060
Human alphaherpesvirus 3 Human alphaherpesvirus 3 IC50 nan None 10.1016/j.bmcl.2010.03.115
Human alphaherpesvirus 3 Human alphaherpesvirus 3 ID50 2.0 uM 10.1021/jm00108a026
Human alphaherpesvirus 3 Human alphaherpesvirus 3 MIC 0.01 ug.mL-1 10.1021/jm991171l
Human alphaherpesvirus 3 Human alphaherpesvirus 3 MIC 0.02 ug.mL-1 10.1021/jm00066a013
Human alphaherpesvirus 3 Human alphaherpesvirus 3 MIC 0.072 ug.mL-1 10.1021/jm00066a013
Human alphaherpesvirus 3 Human alphaherpesvirus 3 MIC 0.1 ug.mL-1 10.1021/jm00066a013
Human alphaherpesvirus 3 Human alphaherpesvirus 3 MIC 0.5 ug.mL-1 10.1021/jm00045a025
Human alphaherpesvirus 3 Human alphaherpesvirus 3 MIC 0.9 ug.mL-1 10.1021/jm00066a013
Human alphaherpesvirus 3 Human alphaherpesvirus 3 MIC 1.4 ug.mL-1 10.1021/jm00045a025
Human alphaherpesvirus 3 Human alphaherpesvirus 3 MIC 1.5 ug.mL-1 10.1021/jm00045a025
Human alphaherpesvirus 3 Human alphaherpesvirus 3 MIC 120.0 ug.mL-1 10.1021/jm00045a025
Human alphaherpesvirus 3 Human alphaherpesvirus 3 MIC nan ug.mL-1 10.1016/S0960-894X(96)00244-2
Human betaherpesvirus 5 Human betaherpesvirus 5 Activity nan None 10.1016/j.ejmech.2011.11.021
Human betaherpesvirus 5 Human betaherpesvirus 5 Activity nan None 10.1021/acs.jmedchem.9b01501
Human betaherpesvirus 5 Human betaherpesvirus 5 Activity nan None 10.1128/aac.01596-09
Human betaherpesvirus 5 Human betaherpesvirus 5 Activity nan None 10.1128/aac.01730-09
Human betaherpesvirus 5 Human betaherpesvirus 5 CC50 100.0 ug.mL-1 10.1016/S0960-894X(97)10048-8
Human betaherpesvirus 5 Human betaherpesvirus 5 CC50 98000.0 nM 10.1016/s0960-894x(99)00538-7
Human betaherpesvirus 5 Human betaherpesvirus 5 CC50 100000.0 nM 10.1021/jm030316s
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 0.1 ug.mL-1 10.1016/S0960-894X(97)00082-6
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 0.51 ug.mL-1 10.1016/j.bmc.2007.03.061
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 0.51 ug.mL-1 10.1016/j.bmc.2008.09.027
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 0.54 ug.mL-1 10.1021/jm800050t
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 0.61 ug.mL-1 10.1021/jm000342f
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 0.64 ug.mL-1 10.1016/j.ejmech.2007.04.010
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 0.74 ug.mL-1 10.1016/s0960-894x(98)00122-x
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 0.8 ug.mL-1 10.1016/j.bmc.2007.03.061
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 0.8 ug.mL-1 10.1016/j.bmc.2008.09.027
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 0.8 ug.mL-1 10.1016/S0960-894X(00)80078-5
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 0.98 ug.mL-1 10.1016/s0960-894x(01)00006-3
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 1.09 ug.mL-1 10.1021/jm000342f
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 1.29 ug.mL-1 10.1021/jm0707166
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 1.4 ug.mL-1 10.1016/j.ejmech.2009.02.030
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 1.5 ug.mL-1 10.1021/jm061281+
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 1.5 ug.mL-1 10.1021/jm800050t
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 1.68 ug.mL-1 10.1021/jm0707166
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 1.79 ug.mL-1 10.1007/s00044-011-9776-0
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 1.9 ug.mL-1 10.1016/j.ejmech.2007.04.010
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 1.9 ug.mL-1 10.1016/S0960-894X(00)80078-5
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 2.68 ug.mL-1 10.1007/s00044-011-9776-0
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 3.4 ug.mL-1 10.1021/np9601871
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 4.07 ug.mL-1 10.1016/s0960-894x(01)00006-3
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 4.9 ug.mL-1 10.1021/jm800050t
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 6.0 ug.mL-1 10.1021/jm800050t
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 6.2 ug.mL-1 10.1021/jm800050t
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 7.6 ug.mL-1 10.1021/jm800050t
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 9.1 ug.mL-1 10.1021/jm800050t
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 9.4 ug.mL-1 10.1021/jm800050t
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 40.0 nM 10.1016/j.ejmech.2011.02.014
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 40.0 nM 10.1021/jm900126v
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 150.0 nM 10.1021/jm0607404
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 230.0 nM 10.1021/jm010227k
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 320.0 nM 10.1128/aac.01596-09
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 630.0 nM 10.1016/j.ejmech.2022.114618
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 630.0 nM 10.1021/jm980321+
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 660.0 nM 10.1021/jm8014662
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 680.0 nM 10.1128/aac.01596-09
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 690.0 nM 10.1021/jm8014662
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 700.0 nM 10.1021/jm8014662
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 720.0 nM 10.1021/acs.jmedchem.9b01501
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 770.0 nM 10.1128/aac.00186-10
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 780.0 nM 10.1016/s0960-894x(01)00735-1
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 800.0 nM 10.1128/aac.01730-09
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 860.0 nM 10.1021/acs.jmedchem.2c00667
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 940.0 nM 10.1128/aac.00186-10
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 950.0 nM 10.1128/aac.00186-10
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 960.0 nM 10.1128/aac.00186-10
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 990.0 nM 10.1128/aac.00186-10
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 990.0 nM 10.1128/aac.01596-09
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 1000.0 nM 10.1128/aac.00186-10
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 1000.0 nM 10.1128/aac.01730-09
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 1010.0 nM 10.1016/j.ejmech.2006.11.002
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 1020.0 nM 10.1128/aac.00186-10
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 1050.0 nM 10.1128/aac.00186-10
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 1060.0 nM 10.1128/aac.00186-10
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 1090.0 nM 10.1128/aac.00186-10
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 1100.0 nM 10.1128/aac.00186-10
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 1100.0 nM 10.1128/aac.00736-07
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 1100.0 nM 10.1128/aac.01596-09
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 1110.0 nM 10.1128/aac.00186-10
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 1130.0 nM 10.1128/aac.00186-10
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 1140.0 nM 10.1128/aac.00186-10
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 1200.0 nM 10.1021/jm8014662
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 1200.0 nM 10.1021/jm900126v
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 1220.0 nM 10.1128/aac.00186-10
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 1230.0 nM 10.1128/aac.00186-10
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 1240.0 nM 10.1128/aac.00186-10
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 1260.0 nM 10.1128/aac.00186-10
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 1300.0 nM 10.1016/j.ejmech.2007.09.001
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 1300.0 nM 10.1021/jm0614329
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 1330.0 nM 10.1128/aac.00186-10
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 1400.0 nM 10.1128/aac.00134-08
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 1500.0 nM 10.1128/aac.00186-10
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 1600.0 nM 10.1021/jm040149b
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 1650.0 nM 10.1016/j.ejmech.2012.03.007
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 1650.0 nM 10.1016/j.ejmech.2022.114857
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 1650.0 nM 10.1128/aac.01596-09
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 1730.0 nM 10.1128/aac.01596-09
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 1740.0 nM 10.1128/aac.01596-09
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 1790.0 nM 10.1016/j.ejmech.2021.113467
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 1800.0 nM 10.1021/jm0607404
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 1850.0 nM 10.1128/aac.00186-10
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 1900.0 nM 10.1128/aac.00988-08
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 1900.0 nM 10.1128/aac.01730-09
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 1910.0 nM 10.1128/aac.01596-09
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 2000.0 nM 10.1021/jm8014662
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 2070.0 nM 10.1128/aac.01596-09
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 2100.0 nM 10.1021/acs.jmedchem.9b01501
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 2100.0 nM 10.1021/jm040093l
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 2100.0 nM 10.1021/jm040149b
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 2140.0 nM 10.1021/acs.jmedchem.5b00804
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 2200.0 nM 10.1021/jm040093l
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 2210.0 nM 10.1128/aac.01596-09
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 2290.0 nM 10.1016/j.bmc.2018.05.034
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 2300.0 nM 10.1021/jm030316s
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 2330.0 nM 10.1128/aac.01596-09
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 2390.0 nM 10.1128/aac.01596-09
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 2500.0 nM 10.1016/j.bmc.2007.11.082
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 2500.0 nM 10.1016/j.ejmech.2009.03.005
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 2600.0 nM 10.1016/j.bmc.2018.05.041
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 2600.0 nM 10.1016/j.bmc.2018.11.018
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 2600.0 nM 10.1021/acsmedchemlett.7b00412
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 2600.0 nM 10.1021/acsmedchemlett.8b00381
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 2600.0 nM 10.1021/jm070324z
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 2600.0 nM 10.1021/jm8014662
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 2600.0 nM 10.1128/aac.00736-07
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 2700.0 nM 10.1128/aac.00736-07
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 2700.0 nM 10.1128/aac.01596-09
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 2750.0 nM 10.1021/jm0701472
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 2760.0 nM 10.1128/aac.00186-10
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 2960.0 nM 10.1016/j.bmc.2017.06.046
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 2980.0 nM 10.1128/aac.00186-10
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 3000.0 nM 10.1128/aac.00134-08
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 3000.0 nM 10.1128/aac.00186-10
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 3020.0 nM 10.1128/aac.00186-10
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 3100.0 nM 10.1016/j.ejmech.2016.09.014
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 3300.0 nM 10.1128/aac.00417-09
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 3310.0 nM 10.1021/acsmedchemlett.8b00079
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 3310.0 nM 10.1128/aac.00186-10
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 3360.0 nM 10.1128/aac.00186-10
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 3500.0 nM 10.1021/jm8014662
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 3500.0 nM 10.1128/aac.00736-07
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 3600.0 nM 10.1021/jm8014662
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 3900.0 nM 10.1128/aac.00736-07
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 4000.0 nM 10.1016/j.bmcl.2003.08.028
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 4000.0 nM 10.1021/jm8014662
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 4050.0 nM 10.1016/j.ejmech.2018.01.086
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 4100.0 nM 10.1021/jm030316s
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 4100.0 nM 10.1128/aac.00468-10
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 4300.0 nM 10.1021/jm8014662
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 4300.0 nM 10.1128/aac.01596-09
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 4600.0 nM 10.1016/j.bmc.2019.02.005
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 4720.0 nM 10.1016/j.ejmech.2015.08.008
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 4800.0 nM 10.1016/j.ejmech.2007.09.001
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 4800.0 nM 10.1021/jm0614329
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 4830.0 nM 10.1016/j.ejmech.2018.03.008
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 5000.0 nM 10.1016/j.ejmech.2022.114857
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 5000.0 nM 10.1128/aac.01596-09
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 5100.0 nM 10.1016/j.bmc.2011.06.045
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 5100.0 nM 10.1021/jm050867d
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 5100.0 nM 10.1021/jm070210n
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 5200.0 nM 10.1021/jm1011462
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 5260.0 nM 10.1128/aac.01596-09
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 5630.0 nM 10.1016/j.ejmech.2018.01.086
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 5700.0 nM 10.1016/j.bmcl.2003.08.028
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 5900.0 nM 10.1016/j.bmc.2011.06.045
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 5900.0 nM 10.1016/j.ejmech.2012.07.027
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 6000.0 nM 10.1016/j.bmc.2011.04.016
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 6100.0 nM 10.1128/aac.00736-07
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 6120.0 nM 10.1016/j.ejmech.2015.08.008
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 6300.0 nM 10.1021/jm0701472
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 6460.0 nM 10.1016/j.ejmech.2018.03.008
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 6500.0 nM 10.1016/j.bmc.2019.02.005
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 6500.0 nM 10.1021/jm070324z
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 6510.0 nM 10.1128/aac.01596-09
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 6520.0 nM 10.1016/j.ejmech.2018.07.062
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 6540.0 nM 10.1016/j.bmc.2011.04.016
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 6600.0 nM 10.1128/aac.00736-07
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 6790.0 nM 10.1016/j.bmc.2017.06.046
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 7000.0 nM 10.1016/j.bmc.2010.12.052
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 7000.0 nM 10.1016/j.bmc.2013.05.009
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 7100.0 nM 10.1016/j.ejmech.2012.04.001
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 7200.0 nM 10.1128/aac.00417-09
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 7300.0 nM 10.1021/acs.jmedchem.7b01009
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 7400.0 nM 10.1021/acs.jmedchem.7b01009
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 7410.0 nM 10.1021/acsmedchemlett.8b00079
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 7500.0 nM 10.1016/j.ejmech.2012.04.001
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 7800.0 nM 10.1016/j.bmc.2015.09.033
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 7810.0 nM 10.1128/aac.00186-10
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 8180.0 nM 10.1128/aac.00186-10
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 8200.0 nM 10.1016/j.ejmech.2013.06.053
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 8270.0 nM 10.1016/j.ejmech.2022.114618
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 8300.0 nM 10.1016/j.bmc.2013.05.009
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 8400.0 nM 10.1128/aac.00736-07
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 8480.0 nM 10.1128/aac.00186-10
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 8520.0 nM 10.1128/aac.00186-10
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 8700.0 nM 10.1021/acs.jmedchem.7b00416
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 8700.0 nM 10.1021/jm050867d
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 8700.0 nM 10.1021/jm070210n
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 9100.0 nM 10.1016/j.ejmech.2012.07.027
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 9240.0 nM 10.1128/aac.00186-10
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 9400.0 nM 10.1021/jm901828c
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 9800.0 nM 10.1128/aac.00417-09
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 10000.0 nM 10.1016/j.bmc.2023.117276
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 10200.0 nM 10.1021/jm901828c
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 11430.0 nM 10.1016/j.bmc.2018.05.034
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 11750.0 nM 10.1016/j.ejmech.2018.07.062
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 12600.0 nM 10.1016/j.ejmech.2009.03.005
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 13900.0 nM 10.1016/j.bmc.2015.09.033
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 14000.0 nM 10.1128/aac.01596-09
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 15000.0 nM 10.1128/aac.00417-09
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 15000.0 nM 10.1128/aac.01596-09
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 16500.0 nM 10.1021/acs.jmedchem.7b00416
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 19000.0 nM 10.1016/j.ejmech.2021.113467
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 22000.0 nM 10.1021/jm900126v
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 29700.0 nM 10.1021/acs.jmedchem.9b01501
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 42000.0 nM 10.1021/jm900126v
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 44000.0 nM 10.1128/aac.00417-09
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 53000.0 nM 10.1128/aac.00417-09
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 230000.0 nM 10.1128/aac.00417-09
Human betaherpesvirus 5 Human betaherpesvirus 5 EC50 2600000.0 nM 10.1016/j.ejmech.2019.03.004
Human betaherpesvirus 5 Human betaherpesvirus 5 EC90 10.7 uM 10.1128/aac.01596-09
Human betaherpesvirus 5 Human betaherpesvirus 5 EC90 18.3 uM 10.1128/aac.01596-09
Human betaherpesvirus 5 Human betaherpesvirus 5 EC90 74.23 uM 10.1021/acs.jmedchem.2c00667
Human betaherpesvirus 5 Human betaherpesvirus 5 EC90 nan None 10.1016/j.ejmech.2011.02.014
Human betaherpesvirus 5 Human betaherpesvirus 5 EC99.9 5.0 uM 10.1016/j.bmcl.2007.01.109
Human betaherpesvirus 5 Human betaherpesvirus 5 ED50 0.21 ug ml-1 10.1021/jm9701536
Human betaherpesvirus 5 Human betaherpesvirus 5 ED50 0.4 ug ml-1 10.1021/jm00145a014
Human betaherpesvirus 5 Human betaherpesvirus 5 ED50 1.0 ug ml-1 10.1021/jm00167a002
Human betaherpesvirus 5 Human betaherpesvirus 5 ED50 2.4 ug ml-1 10.1021/jm00167a002
Human betaherpesvirus 5 Human betaherpesvirus 5 ED50 2.7 ug ml-1 10.1021/jm00167a002
Human betaherpesvirus 5 Human betaherpesvirus 5 ED50 2.8 ug ml-1 10.1021/jm00167a002
Human betaherpesvirus 5 Human betaherpesvirus 5 ED50 3.1 ug ml-1 10.1021/jm00167a002
Human betaherpesvirus 5 Human betaherpesvirus 5 ED50 3.6 ug ml-1 10.1021/jm00167a002
Human betaherpesvirus 5 Human betaherpesvirus 5 FC 2.0 None 10.1128/aac.00736-07
Human betaherpesvirus 5 Human betaherpesvirus 5 FC 2.6 None 10.1128/aac.00736-07
Human betaherpesvirus 5 Human betaherpesvirus 5 FC 5.0 None 10.1128/aac.00736-07
Human betaherpesvirus 5 Human betaherpesvirus 5 IC100 5.0 uM 10.1016/j.bmcl.2006.06.066
Human betaherpesvirus 5 Human betaherpesvirus 5 IC100 10.0 uM 10.1016/j.bmcl.2006.06.066
Human betaherpesvirus 5 Human betaherpesvirus 5 IC50 0.1 ug.mL-1 10.1016/S0960-894X(97)10048-8
Human betaherpesvirus 5 Human betaherpesvirus 5 IC50 0.3 ug.mL-1 10.1016/s0960-894x(00)00265-1
Human betaherpesvirus 5 Human betaherpesvirus 5 IC50 0.3 ug.mL-1 10.1016/s0960-894x(02)00535-8
Human betaherpesvirus 5 Human betaherpesvirus 5 IC50 0.3 ug.mL-1 10.1021/jm9902483
Human betaherpesvirus 5 Human betaherpesvirus 5 IC50 0.4 ug.mL-1 10.1016/s0960-894x(02)00535-8
Human betaherpesvirus 5 Human betaherpesvirus 5 IC50 0.5 ug.mL-1 10.1021/jm981051y
Human betaherpesvirus 5 Human betaherpesvirus 5 IC50 1.2 ug.mL-1 10.1021/jm980327z
Human betaherpesvirus 5 Human betaherpesvirus 5 IC50 1.9 ug.mL-1 10.1021/jm980327z
Human betaherpesvirus 5 Human betaherpesvirus 5 IC50 140.0 nM 10.1021/jm2001426
Human betaherpesvirus 5 Human betaherpesvirus 5 IC50 720.0 nM 10.1021/jm030810w
Human betaherpesvirus 5 Human betaherpesvirus 5 IC50 880.0 nM 10.1021/jm990195p
Human betaherpesvirus 5 Human betaherpesvirus 5 IC50 910.0 nM 10.1016/j.bmcl.2006.12.085
Human betaherpesvirus 5 Human betaherpesvirus 5 IC50 1000.0 nM 10.1016/j.bmcl.2007.01.109
Human betaherpesvirus 5 Human betaherpesvirus 5 IC50 1300.0 nM 10.1016/j.bmcl.2007.03.102
Human betaherpesvirus 5 Human betaherpesvirus 5 IC50 1300.0 nM 10.1016/j.bmcl.2007.05.010
Human betaherpesvirus 5 Human betaherpesvirus 5 IC50 1300.0 nM 10.1016/j.bmcl.2008.06.060
Human betaherpesvirus 5 Human betaherpesvirus 5 IC50 1300.0 nM 10.1016/j.bmcl.2010.01.094
Human betaherpesvirus 5 Human betaherpesvirus 5 IC50 1300.0 nM 10.1021/acs.jmedchem.9b01318
Human betaherpesvirus 5 Human betaherpesvirus 5 IC50 1300.0 nM 10.1128/aac.00633-06
Human betaherpesvirus 5 Human betaherpesvirus 5 IC50 1400.0 nM 10.1128/aac.00633-06
Human betaherpesvirus 5 Human betaherpesvirus 5 IC50 1800.0 nM 10.1021/jm00169a028
Human betaherpesvirus 5 Human betaherpesvirus 5 IC50 1900.0 nM 10.1128/aac.00633-06
Human betaherpesvirus 5 Human betaherpesvirus 5 IC50 2000.0 nM 10.1021/jm990195p
Human betaherpesvirus 5 Human betaherpesvirus 5 IC50 2100.0 nM 10.1016/j.bmc.2012.04.049
Human betaherpesvirus 5 Human betaherpesvirus 5 IC50 2200.0 nM 10.1021/jm950835y
Human betaherpesvirus 5 Human betaherpesvirus 5 IC50 2600.0 nM 10.1016/j.bmc.2015.07.048
Human betaherpesvirus 5 Human betaherpesvirus 5 IC50 3000.0 nM 10.1016/j.bmcl.2006.11.012
Human betaherpesvirus 5 Human betaherpesvirus 5 IC50 3000.0 nM 10.1016/j.bmcl.2011.04.126
Human betaherpesvirus 5 Human betaherpesvirus 5 IC50 3000.0 nM 10.1016/s0960-894x(01)00352-3
Human betaherpesvirus 5 Human betaherpesvirus 5 IC50 3220.0 nM 10.1016/j.bmc.2008.10.081
Human betaherpesvirus 5 Human betaherpesvirus 5 IC50 3600.0 nM 10.1016/j.bmc.2015.07.039
Human betaherpesvirus 5 Human betaherpesvirus 5 IC50 3700.0 nM 10.1021/jm000118q
Human betaherpesvirus 5 Human betaherpesvirus 5 IC50 3900.0 nM 10.1016/s0960-894x(99)00538-7
Human betaherpesvirus 5 Human betaherpesvirus 5 IC50 4100.0 nM 10.1021/jm000118q
Human betaherpesvirus 5 Human betaherpesvirus 5 IC50 4100.0 nM 10.1128/aac.00633-06
Human betaherpesvirus 5 Human betaherpesvirus 5 IC50 4900.0 nM 10.1128/aac.00633-06
Human betaherpesvirus 5 Human betaherpesvirus 5 IC50 5400.0 nM 10.1128/aac.00633-06
Human betaherpesvirus 5 Human betaherpesvirus 5 IC50 5600.0 nM 10.1128/aac.00633-06
Human betaherpesvirus 5 Human betaherpesvirus 5 IC50 5700.0 nM 10.1016/j.bmc.2012.12.027
Human betaherpesvirus 5 Human betaherpesvirus 5 IC50 5900.0 nM 10.1016/s0960-894x(99)00538-7
Human betaherpesvirus 5 Human betaherpesvirus 5 IC50 5900.0 nM 10.1021/jm000033p
Human betaherpesvirus 5 Human betaherpesvirus 5 IC50 5900.0 nM 10.1021/jm000118q
Human betaherpesvirus 5 Human betaherpesvirus 5 IC50 6200.0 nM 10.1021/jm000118q
Human betaherpesvirus 5 Human betaherpesvirus 5 IC50 6300.0 nM 10.1016/j.bmc.2012.12.027
Human betaherpesvirus 5 Human betaherpesvirus 5 IC50 7100.0 nM 10.1128/aac.00633-06
Human betaherpesvirus 5 Human betaherpesvirus 5 IC50 7400.0 nM 10.1021/jm00020a025
Human betaherpesvirus 5 Human betaherpesvirus 5 IC50 7400.0 nM 10.1021/jm00020a026
Human betaherpesvirus 5 Human betaherpesvirus 5 IC50 7400.0 nM 10.1021/jm00044a015
Human betaherpesvirus 5 Human betaherpesvirus 5 IC50 7400.0 nM 10.1021/jm0400146
Human betaherpesvirus 5 Human betaherpesvirus 5 IC50 7400.0 nM 10.1021/jm040016q
Human betaherpesvirus 5 Human betaherpesvirus 5 IC50 7400.0 nM 10.1021/jm950556a
Human betaherpesvirus 5 Human betaherpesvirus 5 IC50 7400.0 nM 10.1021/jm960157v
Human betaherpesvirus 5 Human betaherpesvirus 5 IC50 7400.0 nM 10.1021/jm960462g
Human betaherpesvirus 5 Human betaherpesvirus 5 IC50 7400.0 nM 10.1021/jm9604888
Human betaherpesvirus 5 Human betaherpesvirus 5 IC50 7400.0 nM 10.1021/jm960533b
Human betaherpesvirus 5 Human betaherpesvirus 5 IC50 7400.0 nM 10.1021/jm970545c
Human betaherpesvirus 5 Human betaherpesvirus 5 IC50 7700.0 nM 10.1021/jm00020a027
Human betaherpesvirus 5 Human betaherpesvirus 5 IC50 7700.0 nM 10.1021/jm00076a011
Human betaherpesvirus 5 Human betaherpesvirus 5 IC50 7700.0 nM 10.1021/jm970532z
Human betaherpesvirus 5 Human betaherpesvirus 5 IC50 7900.0 nM 10.1016/S0960-894X(00)80628-9
Human betaherpesvirus 5 Human betaherpesvirus 5 IC50 7900.0 nM 10.1021/jm00127a003
Human betaherpesvirus 5 Human betaherpesvirus 5 IC50 8200.0 nM 10.1021/jm000118q
Human betaherpesvirus 5 Human betaherpesvirus 5 IC50 8400.0 nM 10.1021/jm00081a014
Human betaherpesvirus 5 Human betaherpesvirus 5 IC50 8700.0 nM 10.1021/jm00169a027
Human betaherpesvirus 5 Human betaherpesvirus 5 IC50 8700.0 nM 10.1021/jm00169a028
Human betaherpesvirus 5 Human betaherpesvirus 5 IC50 8700.0 nM 10.1021/jm950835y
Human betaherpesvirus 5 Human betaherpesvirus 5 IC50 8800.0 nM 10.1021/jm00119a006
Human betaherpesvirus 5 Human betaherpesvirus 5 IC50 8800.0 nM 10.1021/jm00122a019
Human betaherpesvirus 5 Human betaherpesvirus 5 IC50 9200.0 nM 10.1021/jm00174a011
Human betaherpesvirus 5 Human betaherpesvirus 5 IC50 10000.0 nM 10.1128/aac.00633-06
Human betaherpesvirus 5 Human betaherpesvirus 5 IC50 12400.0 nM 10.1128/aac.00633-06
Human betaherpesvirus 5 Human betaherpesvirus 5 IC50 16400.0 nM 10.1016/j.bmc.2008.10.081
Human betaherpesvirus 5 Human betaherpesvirus 5 IC50 30100.0 nM 10.1128/aac.00633-06
Human betaherpesvirus 5 Human betaherpesvirus 5 IC50 30200.0 nM 10.1128/aac.00633-06
Human betaherpesvirus 5 Human betaherpesvirus 5 IC50 100000.0 nM 10.1021/jm00044a015
Human betaherpesvirus 5 Human betaherpesvirus 5 IC50 nan None 10.1016/j.bmc.2008.10.081
Human betaherpesvirus 5 Human betaherpesvirus 5 IC90 1.8 PuM 10.1021/jm00174a011
Human betaherpesvirus 5 Human betaherpesvirus 5 IC90 1600.0 nM 10.1021/jm00020a025
Human betaherpesvirus 5 Human betaherpesvirus 5 IC90 1600.0 nM 10.1021/jm00020a026
Human betaherpesvirus 5 Human betaherpesvirus 5 IC90 1600.0 nM 10.1021/jm00044a015
Human betaherpesvirus 5 Human betaherpesvirus 5 IC90 1600.0 nM 10.1021/jm950556a
Human betaherpesvirus 5 Human betaherpesvirus 5 IC90 1600.0 nM 10.1021/jm960157v
Human betaherpesvirus 5 Human betaherpesvirus 5 IC90 1600.0 nM 10.1021/jm960462g
Human betaherpesvirus 5 Human betaherpesvirus 5 IC90 1600.0 nM 10.1021/jm9604888
Human betaherpesvirus 5 Human betaherpesvirus 5 IC90 1600.0 nM 10.1021/jm960533b
Human betaherpesvirus 5 Human betaherpesvirus 5 IC90 1600.0 nM 10.1021/jm970545c
Human betaherpesvirus 5 Human betaherpesvirus 5 IC90 1800.0 nM 10.1021/jm00020a027
Human betaherpesvirus 5 Human betaherpesvirus 5 IC90 1800.0 nM 10.1021/jm00076a011
Human betaherpesvirus 5 Human betaherpesvirus 5 IC90 1800.0 nM 10.1021/jm00081a014
Human betaherpesvirus 5 Human betaherpesvirus 5 IC90 2000.0 nM 10.1016/S0960-894X(00)80628-9
Human betaherpesvirus 5 Human betaherpesvirus 5 ID50 1.8 ug ml-1 10.1021/jm00127a010
Human betaherpesvirus 5 Human betaherpesvirus 5 ID50 2.0 uM 10.1021/jm00108a026
Human betaherpesvirus 5 Human betaherpesvirus 5 ID50 5.0 ug ml-1 10.1021/jm00168a039
Human betaherpesvirus 5 Human betaherpesvirus 5 ID50 6.0 uM 10.1021/jm00147a020
Human betaherpesvirus 5 Human betaherpesvirus 5 ID50 100.0 ug ml-1 10.1021/jm00167a002
Human betaherpesvirus 5 Human betaherpesvirus 5 Inhibition 30.0 % 10.1021/jm800787b
Human betaherpesvirus 5 Human betaherpesvirus 5 Inhibition 98.0 % 10.1128/aac.01730-09
Human betaherpesvirus 5 Human betaherpesvirus 5 MIC 1.5 ug.mL-1 10.1021/jm00045a025
Human betaherpesvirus 5 Human betaherpesvirus 5 MIC50 0.7 ug.mL-1 10.1021/jm950891z
Human betaherpesvirus 5 Human betaherpesvirus 5 NA nan None 10.1021/jm00171a022
Human betaherpesvirus 5 Human betaherpesvirus 5 Ratio EC50 0.8 None 10.1128/aac.00186-10
Human betaherpesvirus 5 Human betaherpesvirus 5 Ratio EC50 0.9 None 10.1128/aac.00186-10
Human betaherpesvirus 5 Human betaherpesvirus 5 Ratio EC50 1.0 None 10.1128/aac.00186-10
Human betaherpesvirus 5 Human betaherpesvirus 5 Ratio EC50 1.1 None 10.1128/aac.00186-10
Human betaherpesvirus 5 Human betaherpesvirus 5 Ratio EC50 1.2 None 10.1128/aac.00186-10
Human betaherpesvirus 5 Human betaherpesvirus 5 Ratio EC50 1.3 None 10.1128/aac.00186-10
Human betaherpesvirus 5 Human betaherpesvirus 5 Ratio EC50 1.4 None 10.1128/aac.00186-10
Human betaherpesvirus 5 Human betaherpesvirus 5 Ratio EC50 1.9 None 10.1128/aac.00186-10
Human betaherpesvirus 5 Human betaherpesvirus 5 Ratio EC50 2.5 None 10.1128/aac.00186-10
Human betaherpesvirus 5 Human betaherpesvirus 5 Ratio EC50 2.7 None 10.1128/aac.00186-10
Human betaherpesvirus 5 Human betaherpesvirus 5 Ratio EC50 3.0 None 10.1128/aac.00186-10
Human betaherpesvirus 5 Human betaherpesvirus 5 Ratio EC50 7.9 None 10.1128/aac.00186-10
Human betaherpesvirus 5 Human betaherpesvirus 5 Ratio EC50 8.3 None 10.1128/aac.00186-10
Human betaherpesvirus 5 Human betaherpesvirus 5 Ratio EC50 8.6 None 10.1128/aac.00186-10
Human betaherpesvirus 5 Human betaherpesvirus 5 Ratio EC50 9.3 None 10.1128/aac.00186-10
Human betaherpesvirus 6 Human betaherpesvirus 6 EC50 nan None 10.1021/jm901828c
Human cytomegalovirus Tripartite terminase subunit 3 Delta Tm -0.1 degrees C 10.1016/j.ejmech.2021.113640
Human gammaherpesvirus 4 Human gammaherpesvirus 4 Activity nan None 10.1021/jm00396a021
Human gammaherpesvirus 4 Human gammaherpesvirus 4 EC50 5000.0 nM 10.1021/jm040093l
Human gammaherpesvirus 4 Human gammaherpesvirus 4 EC50 5000.0 nM 10.1021/jm040149b
Human gammaherpesvirus 4 Human gammaherpesvirus 4 EC50 5000.0 nM 10.1021/jm0607404
Human gammaherpesvirus 4 Human gammaherpesvirus 4 EC50 5200.0 nM 10.1021/acs.jmedchem.9b01501
Human gammaherpesvirus 4 Human gammaherpesvirus 4 EC50 50000.0 nM 10.1021/jm9806749
Human gammaherpesvirus 4 Human gammaherpesvirus 4 EC50 nan nM 10.1016/s0960-894x(01)00735-1
Human gammaherpesvirus 4 Human gammaherpesvirus 4 IC50 50.0 nM 10.1021/jm00396a021
Human gammaherpesvirus 4 Human gammaherpesvirus 4 IC50 nan None 10.1016/j.bmcl.2008.06.060
Human gammaherpesvirus 8 Human gammaherpesvirus 8 IC50 70000.0 nM 10.1021/jm070032y
Human gammaherpesvirus 8 Human gammaherpesvirus 8 IC50 81000.0 nM 10.1021/jm070032y
Human herpesvirus 5 strain AD169 Human herpesvirus 5 strain AD169 EC50 12000.0 nM 10.1128/aac.01596-09
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Activity nan None 10.1016/j.ejmech.2011.11.021
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 5000.0 nM 10.1021/acs.jmedchem.7b01009
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 50000.0 nM 10.1021/acs.jmedchem.7b01009
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 50000.0 nM 10.1021/jm0504306
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 nan ug.mL-1 10.1016/s0960-894x(98)00122-x
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 nan None 10.1016/j.ejmech.2006.11.002
Human immunodeficiency virus 1 Human immunodeficiency virus 1 NA nan None 10.1021/jm00171a022
Human immunodeficiency virus 2 Human immunodeficiency virus 2 Activity nan None 10.1016/j.ejmech.2011.11.021
Human immunodeficiency virus 2 Human immunodeficiency virus 2 EC50 50000.0 nM 10.1021/jm0504306
Human respirovirus 3 Human respirovirus 3 Activity nan None 10.1016/j.ejmech.2011.11.021
Human respirovirus 3 Human respirovirus 3 MIC50 nan None 10.1021/jm050772b
Influenza A virus Influenza A virus Activity nan None 10.1016/j.ejmech.2011.11.021
Influenza B virus Influenza B virus Activity nan None 10.1016/j.ejmech.2011.11.021
Klebsiella pneumoniae Klebsiella pneumoniae Inhibition 11.05 % 10.6019/CHEMBL4513141
Klebsiella pneumoniae Klebsiella pneumoniae MIC 20000.0 nM 10.6019/CHEMBL4513161
Leishmania donovani Leishmania donovani IC50 117540.0 nM 10.6019/CHEMBL3392926
Leishmania donovani Leishmania donovani IC50 391800.0 nM 10.6019/CHEMBL3392926
Macacine alphaherpesvirus 1 Macacine alphaherpesvirus 1 Activity 100.0 % 10.1128/aac.01435-08
Macacine alphaherpesvirus 1 Macacine alphaherpesvirus 1 EC50 14500.0 nM 10.1128/aac.01284-06
Macacine alphaherpesvirus 1 Macacine alphaherpesvirus 1 EC50 19200.0 nM 10.1128/aac.01284-06
Macacine alphaherpesvirus 1 Macacine alphaherpesvirus 1 EC50 19300.0 nM 10.1128/aac.01435-08
Macacine alphaherpesvirus 1 Macacine alphaherpesvirus 1 EC50 23500.0 nM 10.1128/aac.01284-06
Macacine herpesvirus 1 Thymidine kinase Activity nan None 10.1128/aac.01284-06
Macacine herpesvirus 1 Thymidine kinase IC50 800000.0 nM 10.1128/aac.01284-06
Maize chlorotic mottle virus Maize chlorotic mottle virus EC50 5.0 ug.mL-1 10.1021/np9703914
Mammalian orthoreovirus 1 Mammalian orthoreovirus 1 Activity nan None 10.1016/j.ejmech.2011.11.021
Mammalian orthoreovirus 1 Mammalian orthoreovirus 1 MIC50 nan None 10.1021/jm050772b
Murid betaherpesvirus 1 Murid betaherpesvirus 1 Activity 5.7 day 10.1016/j.bmc.2012.02.031
Murid betaherpesvirus 1 Murid betaherpesvirus 1 Activity 6.0 day 10.1016/j.bmc.2012.02.031
Murid betaherpesvirus 1 Murid betaherpesvirus 1 Activity 6.3 day 10.1016/j.bmc.2012.02.031
Murid betaherpesvirus 1 Murid betaherpesvirus 1 Activity 6.4 day 10.1016/j.bmc.2012.02.031
Murid betaherpesvirus 1 Murid betaherpesvirus 1 Activity 6.8 day 10.1016/j.bmc.2012.02.031
Murid betaherpesvirus 1 Murid betaherpesvirus 1 Activity 7.0 % 10.1016/j.bmc.2012.02.031
Murid betaherpesvirus 1 Murid betaherpesvirus 1 Activity 7.3 day 10.1016/j.bmc.2012.02.031
Murid betaherpesvirus 1 Murid betaherpesvirus 1 Activity 20.0 % 10.1016/j.bmc.2012.02.031
Murid betaherpesvirus 1 Murid betaherpesvirus 1 Activity 53.0 % 10.1016/j.bmc.2012.02.031
Murid betaherpesvirus 1 Murid betaherpesvirus 1 Activity 87.0 % 10.1016/j.bmc.2012.02.031
Murid betaherpesvirus 1 Murid betaherpesvirus 1 Activity 93.0 % 10.1016/j.bmc.2012.02.031
Murid betaherpesvirus 1 Murid betaherpesvirus 1 CC50 35000.0 nM 10.1021/jm030316s
Murid betaherpesvirus 1 Murid betaherpesvirus 1 EC50 5.0 ug.mL-1 10.1021/np9601871
Murid betaherpesvirus 1 Murid betaherpesvirus 1 EC50 13.8 ug.mL-1 10.1021/np9601871
Murid betaherpesvirus 1 Murid betaherpesvirus 1 EC50 5500.0 nM 10.1021/jm900126v
Murid betaherpesvirus 1 Murid betaherpesvirus 1 ED50 1.9 mg kg-1 day-1 10.1021/jm00167a002
Murid betaherpesvirus 1 Murid betaherpesvirus 1 ID50 4.0 uM 10.1021/jm00108a026
Murid betaherpesvirus 1 Murid betaherpesvirus 1 ID50 100.0 ug ml-1 10.1021/jm00167a002
Murid betaherpesvirus 1 Murid betaherpesvirus 1 MDD 7.6 None 10.1021/jm00167a002
Murid betaherpesvirus 1 Murid betaherpesvirus 1 Survivors / treated 10.0 None 10.1021/jm00167a002
Murid betaherpesvirus 1 Murid betaherpesvirus 1 Survivors / treated 15.0 None 10.1021/jm00167a002
Mus musculus J774.A1 Activity nan None 10.1128/aac.01029-10
Mus musculus MEF CC50 392000.0 nM 10.1021/jm040149b
Mus musculus MEF EC50 5000.0 nM 10.1021/jm030316s
Mus musculus MEF IC50 3400.0 nM 10.1021/jm9705723
Mus musculus MEF IC50 nan nM 10.1021/jm9705723
Mus musculus Mus musculus Activity 4.0 None 10.1021/jm00169a028
Mus musculus Mus musculus Activity 5.0 None 10.1021/jm00169a028
Mus musculus Mus musculus Activity 7.0 None 10.1021/jm00169a028
Mus musculus Mus musculus Activity 8.0 None 10.1021/jm00169a028
Mus musculus Mus musculus Activity 10.0 None 10.1021/jm00169a028
Mus musculus Mus musculus Activity 11.0 None 10.1021/jm00169a028
Mus musculus Mus musculus Activity 12.0 None 10.1021/jm00169a028
Mus musculus Mus musculus Activity 14.0 None 10.1021/jm00169a028
Mus musculus Mus musculus Average survival 14.6 day 10.1021/jm00145a014
Mus musculus Mus musculus MDD 3.8 None 10.1021/jm00169a028
Mus musculus Mus musculus MDD 4.2 None 10.1021/jm00169a028
Mus musculus Mus musculus MDD 4.6 None 10.1021/jm00169a028
Mus musculus Mus musculus MDD 4.9 None 10.1021/jm00169a028
Mus musculus Mus musculus MDD 5.3 None 10.1021/jm00169a028
Mus musculus Mus musculus MDD 5.4 None 10.1021/jm00169a028
Mus musculus Mus musculus MDD 5.5 None 10.1021/jm00169a028
Mus musculus Mus musculus Mean day appearance of lesions 8.2 None 10.1021/jm00167a019
Mus musculus Mus musculus Mean day appearance of lesions 12.0 None 10.1021/jm00167a019
Mus musculus Mus musculus Mean day appearance of lesions 14.2 None 10.1021/jm00167a019
Mus musculus Mus musculus Mean day appearance of lesions 16.7 None 10.1021/jm00167a019
Mus musculus Mus musculus Mean day appearance of lesions 17.0 None 10.1021/jm00167a019
Mus musculus Mus musculus Mean day appearance of lesions 29.0 None 10.1021/jm00167a019
Mus musculus Mus musculus Mean day of death for total dead 3.6 None 10.1021/jm00108a026
Mus musculus Mus musculus Mean day of death for total dead 4.4 None 10.1021/jm00108a026
Mus musculus Mus musculus Mean day of death for total dead 4.8 None 10.1021/jm00108a026
Mus musculus Mus musculus Mean day of death for total dead 5.7 None 10.1021/jm00108a026
Mus musculus Mus musculus Mean survival time 0.001 None 10.1021/jm00147a020
Mus musculus Mus musculus Mean survival time 11.2 day 10.1021/jm00147a020
Mus musculus Mus musculus Mean survival time 12.4 day 10.1021/jm00147a020
Mus musculus Mus musculus Mean survival time 13.8 day 10.1021/jm00147a020
Mus musculus Mus musculus Mean survival time nan None 10.1021/jm00147a020
Mus musculus Mus musculus Mortality 27.0 % 10.1021/jm00169a028
Mus musculus Mus musculus Mortality 33.0 % 10.1021/jm00169a028
Mus musculus Mus musculus Mortality 47.0 % 10.1021/jm00169a028
Mus musculus Mus musculus Mortality 53.0 % 10.1021/jm00169a028
Mus musculus Mus musculus Mortality 67.0 % 10.1021/jm00169a028
Mus musculus Mus musculus Mortality 73.0 % 10.1021/jm00169a028
Mus musculus Mus musculus Mortality 80.0 % 10.1021/jm00169a028
Mus musculus Mus musculus Mortality 93.0 % 10.1021/jm00169a028
Mus musculus Mus musculus MST 10.9 day 10.1021/jm00155a015
Mus musculus Mus musculus MST 11.3 day 10.1021/jm00155a015
Mus musculus Mus musculus MST 11.9 day 10.1021/jm00155a015
Mus musculus Mus musculus MST 12.4 day 10.1021/jm00155a015
Mus musculus Mus musculus MST 13.5 day 10.1021/jm00158a011
Mus musculus Mus musculus MST 13.8 day 10.1021/jm00155a015
Mus musculus Mus musculus MST 21.0 day 10.1021/jm00155a015
Mus musculus Mus musculus MST increase 0.001 None 10.1021/jm00155a015
Mus musculus Mus musculus MST increase 0.01 None 10.1021/jm00155a015
Mus musculus Mus musculus MST increase 0.025 None 10.1021/jm00155a015
Mus musculus Mus musculus MTS 11.6 day 10.1021/jm00167a019
Mus musculus Mus musculus MTS 22.2 day 10.1021/jm00167a019
Mus musculus Mus musculus MTS 23.2 day 10.1021/jm00167a019
Mus musculus Mus musculus MTS 35.6 day 10.1021/jm00167a019
Mus musculus Mus musculus MTS 40.4 day 10.1021/jm00167a019
Mus musculus Mus musculus MTS 43.4 day 10.1021/jm00167a019
Mus musculus Mus musculus PD50 12.5 mg kg-1 day-1 10.1021/jm00108a026
Mus musculus Mus musculus PD50 57.0 mg kg-1 day-1 10.1021/jm00108a026
Mus musculus Mus musculus Survival 5.0 None 10.1021/jm00381a015
Mus musculus Mus musculus Survival 8.0 None 10.1021/jm00381a015
Mus musculus Mus musculus Survival time 9.9 day 10.1021/jm00381a015
Mus musculus Mus musculus Survival time 10.9 day 10.1021/jm00381a015
Mus musculus Mus musculus Survival time 13.8 day 10.1021/jm00381a015
Mus musculus Mus musculus Survivor increase 0.001 None 10.1021/jm00155a015
Mus musculus Mus musculus Survivor increase 0.005 None 10.1021/jm00155a015
Mus musculus Mus musculus Survivor increase 0.01 None 10.1021/jm00155a015
Mus musculus Mus musculus Survivor increase nan None 10.1021/jm00155a015
Mus musculus Mus musculus Survivors 0.0 None 10.1021/jm00155a015
Mus musculus Mus musculus Survivors 4.0 None 10.1021/jm00147a020
Mus musculus Mus musculus Survivors 6.0 None 10.1021/jm00155a015
Mus musculus Mus musculus Survivors 7.0 None 10.1021/jm00147a020
Mus musculus Mus musculus Survivors 8.0 None 10.1021/jm00155a015
Mus musculus Mus musculus Survivors 10.0 None 10.1021/jm00155a015
Mus musculus Mus musculus Survivors 10.0 None 10.1021/jm00158a011
Mus musculus Mus musculus Survivors 11.0 None 10.1021/jm00155a015
Mus musculus Mus musculus Survivors 12.0 None 10.1021/jm00147a020
Mus musculus Mus musculus Survivors 15.0 None 10.1021/jm00155a015
Mus musculus Mus musculus Survivors alive/total 1.0 None 10.1021/jm00108a026
Mus musculus Mus musculus Survivors alive/total 5.0 None 10.1021/jm00108a026
Mus musculus Mus musculus Survivors alive/total 7.0 None 10.1021/jm00108a026
Mus musculus Mus musculus Survivors alive/total 10.0 None 10.1021/jm00108a026
Mus musculus Nitric oxide synthase, inducible IC50 nan None None
Mus musculus Nitric oxide synthase, inducible Ki nan None None
Mycobacterium tuberculosis Purine nucleoside phosphorylase Kd 15848.93 nM 10.1016/j.bmc.2010.05.009
Oryctolagus cuniculus Angiotensin-converting enzyme IC50 nan None None
Oryctolagus cuniculus Angiotensin-converting enzyme Ki nan None None
Oryctolagus cuniculus Arachidonate 15-lipoxygenase IC50 nan None None
Oryctolagus cuniculus Arachidonate 15-lipoxygenase Ki nan None None
Oryctolagus cuniculus Oryctolagus cuniculus ED50 3.0 ug ml-1 10.1021/jm00120a010
Oryctolagus cuniculus Oryctolagus cuniculus MCC 400.0 ug.mL-1 10.1021/jm00167a019
Plasmodium falciparum Plasmodium falciparum EC50 nan None 10.1016/j.bmc.2018.11.018
Plasmodium falciparum Plasmodium falciparum IC50 195900.0 nM 10.6019/CHEMBL3392926
Pseudomonas aeruginosa Pseudomonas aeruginosa Inhibition 9.56 % 10.6019/CHEMBL4513141
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 20000.0 nM 10.6019/CHEMBL4513161
Punta Toro virus Punta Toro virus Activity nan None 10.1016/j.ejmech.2011.11.021
Punta Toro virus Punta Toro virus MIC50 nan None 10.1021/jm050772b
Rattus norvegicus Aldose reductase IC50 nan None None
Rattus norvegicus Aldose reductase Ki nan None None
Rattus norvegicus Alpha-1a adrenergic receptor IC50 nan None None
Rattus norvegicus Alpha-1a adrenergic receptor Ki nan None None
Rattus norvegicus Alpha-1b adrenergic receptor IC50 nan None None
Rattus norvegicus Alpha-1b adrenergic receptor Ki nan None None
Rattus norvegicus Androgen Receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Rattus norvegicus Androgen Receptor IC50 nan None None
Rattus norvegicus Androgen Receptor Ki nan None None
Rattus norvegicus Brain AUC 170.0 ng.hr.mL-1 10.1124/dmd.112.046391
Rattus norvegicus Brain AUC 182.0 ng.hr.mL-1 10.1124/dmd.112.046391
Rattus norvegicus Cerebrospinal fluid AUC 78.4 ng.hr.mL-1 10.1124/dmd.112.046391
Rattus norvegicus Cerebrospinal fluid AUC 82.5 ng.hr.mL-1 10.1124/dmd.112.046391
Rattus norvegicus Cyclooxygenase-1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Rattus norvegicus GABA receptor alpha-1 subunit AC50 30000.0 nM 10.1038/s41467-023-40064-9
Rattus norvegicus Glutamate (NMDA) receptor subunit zeta 1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Rattus norvegicus Glycine receptor IC50 nan None None
Rattus norvegicus Glycine receptor Ki nan None None
Rattus norvegicus Insulin receptor IC50 nan None None
Rattus norvegicus Insulin receptor Ki nan None None
Rattus norvegicus Nitric-oxide synthase, brain IC50 nan None None
Rattus norvegicus Nitric-oxide synthase, brain Ki nan None None
Rattus norvegicus Plasma AUC 1700.0 ng.hr.mL-1 10.1124/dmd.112.046391
Rattus norvegicus Plasma AUC 1720.0 ng.hr.mL-1 10.1124/dmd.112.046391
Rattus norvegicus Plasma Fu 0.99 None 10.1021/jm901371v
Rattus norvegicus Rattus norvegicus ALB 41700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALB 42000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALB 43000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 313.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 319.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 323.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 345.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALT 42.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALT 45.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALT 47.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALT 48.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AST 76.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AST 78.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AST 91.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AST 96.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AUC 209.7 None 10.1016/0960-894X(96)00294-6
Rattus norvegicus Rattus norvegicus BASO 0.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BASOLE 0.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BILI 1.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BILI 2.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BUN 180.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BUN 190.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BUN 193.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BUN 196.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHLORIDE 102.33 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHLORIDE 103.0 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHLORIDE 103.67 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHLORIDE 106.33 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 653.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 676.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 746.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 796.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CK 220.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CK 222.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CK 428.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CK 635.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CO2 24000000.0 nM 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CO2 25330000.0 nM 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CO2 27330000.0 nM 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CO2 29330000.0 nM 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CREAT 1.5 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CREAT 1.8 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CREAT 2.1 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CREAT 2.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus Dose 3.0 % 10.1021/jm980321+
Rattus norvegicus Rattus norvegicus EOS 86.67 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOS 152.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOS 164.33 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOS 180.33 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOSLE 0.67 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOSLE 1.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOSLE 1.67 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus F 3.6 % 10.1016/0960-894X(96)00294-6
Rattus norvegicus Rattus norvegicus GLUC 1506.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus GLUC 1570.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus GLUC 1650.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 33.9 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 34.33 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 35.17 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 35.37 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HGB 129000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HGB 131300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HGB 131700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HGB 132300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LD50 80.0 mg.kg-1 10.1007/s00044-013-0819-6
Rattus norvegicus Rattus norvegicus LDH 181.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LDH 239.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LDH 646.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LDH 720.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LIPASE 8.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LIPASE 9.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYM 11979.33 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYM 12632.33 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYM 12965.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYM 13318.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYMLE 85.67 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYMLE 86.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYMLE 87.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCH 23.27 pg 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCH 23.37 pg 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCH 23.43 pg 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCH 23.93 pg 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 374700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 380700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 382700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 61.57 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 62.13 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 62.37 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 62.6 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONO 137.33 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONO 365.67 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONO 432.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONO 505.67 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONOLE 1.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONOLE 2.33 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONOLE 3.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONOLE 3.33 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTLE 8.33 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTLE 10.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTLE 10.67 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTLE 11.33 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTSG 1155.33 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTSG 1530.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTSG 1544.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTSG 1652.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOS 114.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOS 117.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOS 123.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOS 142.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 1168000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 1216670.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 1360000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 1439000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 5.57 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 6.13 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 6.54 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 6.69 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PROT 57700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PROT 59000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PROT 59300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBC 5490000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBC 5520000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBC 5640000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBC 5690000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBCNUC 0.0 /100WBC 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBCNUC 0.33 /100WBC 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus SODIUM 145.5 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus SODIUM 145.57 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus SODIUM 145.77 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus SODIUM 145.9 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus URATE 8.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus URATE 12.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus URATE 14.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus URATE 22.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WBC 13730.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WBC 14400.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WBC 15170.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WBC 15500.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus RG2 CC50 377000.0 nM 10.1021/jm800501d
Rattus norvegicus Serotonin 1a (5-HT1a) receptor IC50 nan None None
Rattus norvegicus Serotonin 1a (5-HT1a) receptor Ki nan None None
Rattus norvegicus Serotonin 1b (5-HT1b) receptor IC50 nan None None
Rattus norvegicus Serotonin 1b (5-HT1b) receptor Ki nan None None
Rattus norvegicus Thioredoxin reductase 1, cytoplasmic Potency 7079.5 nM None
Rattus norvegicus Voltage-gated L-type calcium channel alpha-1C subunit AC50 30000.0 nM 10.1038/s41467-023-40064-9
Respiratory syncytial virus Respiratory syncytial virus Activity nan None 10.1016/j.ejmech.2011.11.021
Respiratory syncytial virus Respiratory syncytial virus MIC50 nan None 10.1021/jm050772b
Severe acute respiratory syndrome coronavirus 2 Replicase polyprotein 1ab Inhibition 6.335 % 10.6019/CHEMBL4495564
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Hit score 0.1061 None 10.1101/2020.04.21.054387
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 IC50 19952.62 nM 10.6019/CHEMBL4651402
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 IC50 20000.0 nM 10.6019/CHEMBL4651402
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Inhibition -0.14 % 10.6019/CHEMBL4495565
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Inhibition 3.23 % 10.21203/rs.3.rs-23951/v1
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Inhibition index 0.1348 None 10.1101/2020.04.03.023846
Sindbis virus Sindbis virus Activity nan None 10.1016/j.ejmech.2011.11.021
Sindbis virus Sindbis virus MIC50 nan None 10.1021/jm050772b
Staphylococcus aureus Staphylococcus aureus Inhibition 7.88 % 10.6019/CHEMBL4513141
Staphylococcus aureus Staphylococcus aureus MIC 20000.0 nM 10.6019/CHEMBL4513161
Trypanosoma brucei rhodesiense Trypanosoma brucei rhodesiense IC50 251530.0 nM 10.6019/CHEMBL3392926
Trypanosoma cruzi Trypanosoma cruzi IC50 240170.0 nM 10.6019/CHEMBL3392926
Vaccinia virus Vaccinia virus Activity nan None 10.1016/j.ejmech.2011.11.021
Vaccinia virus Vaccinia virus EC50 100.0 ug.mL-1 10.1016/j.ejmech.2008.08.010
Vaccinia virus Vaccinia virus EC50 100.0 ug.mL-1 10.1016/j.ejmech.2009.03.038
Vaccinia virus Vaccinia virus EC50 100.0 ug.mL-1 10.1016/j.ejmech.2010.07.058
Vaccinia virus Vaccinia virus EC50 100.0 ug.mL-1 10.1016/j.ejmech.2010.09.065
Vaccinia virus Vaccinia virus EC50 100.0 ug.mL-1 10.1021/jm025569k
Vaccinia virus Vaccinia virus EC50 100.0 ug.mL-1 10.1021/jm0701472
Vaccinia virus Vaccinia virus EC50 93000.0 nM 10.1016/j.ejmech.2012.07.027
Vaccinia virus Vaccinia virus EC50 100000.0 nM 10.1007/s00044-009-9248-y
Vaccinia virus Vaccinia virus EC50 100000.0 nM 10.1007/s00044-012-0184-x
Vaccinia virus Vaccinia virus EC50 100000.0 nM 10.1016/j.bmc.2011.05.037
Vaccinia virus Vaccinia virus EC50 100000.0 nM 10.1016/j.bmc.2011.06.045
Vaccinia virus Vaccinia virus EC50 100000.0 nM 10.1016/j.bmc.2015.04.079
Vaccinia virus Vaccinia virus EC50 100000.0 nM 10.1016/j.bmc.2015.12.008
Vaccinia virus Vaccinia virus EC50 100000.0 nM 10.1016/j.bmc.2017.06.046
Vaccinia virus Vaccinia virus EC50 100000.0 nM 10.1016/j.bmc.2018.05.034
Vaccinia virus Vaccinia virus EC50 100000.0 nM 10.1016/j.bmcl.2012.09.079
Vaccinia virus Vaccinia virus EC50 100000.0 nM 10.1016/j.bmcl.2018.09.019
Vaccinia virus Vaccinia virus EC50 100000.0 nM 10.1016/j.ejmech.2009.12.002
Vaccinia virus Vaccinia virus EC50 100000.0 nM 10.1016/j.ejmech.2010.12.017
Vaccinia virus Vaccinia virus EC50 100000.0 nM 10.1016/j.ejmech.2012.03.007
Vaccinia virus Vaccinia virus EC50 100000.0 nM 10.1016/j.ejmech.2013.05.046
Vaccinia virus Vaccinia virus EC50 100000.0 nM 10.1016/j.ejmech.2018.07.062
Vaccinia virus Vaccinia virus EC50 100000.0 nM 10.1016/j.ejmech.2019.111739
Vaccinia virus Vaccinia virus EC50 100000.0 nM 10.1016/j.ejmech.2022.114618
Vaccinia virus Vaccinia virus EC50 100000.0 nM 10.1021/jm060030y
Vaccinia virus Vaccinia virus EC50 100000.0 nM 10.1021/jm1011462
Vaccinia virus Vaccinia virus EC50 100000.0 nM 10.1021/jm801470b
Vaccinia virus Vaccinia virus EC50 100000.0 nM 10.1021/ml2001054
Vaccinia virus Vaccinia virus EC50 250000.0 nM 10.1016/j.bmc.2011.04.016
Vaccinia virus Vaccinia virus EC50 nan None 10.1016/j.ejmech.2011.02.014
Vaccinia virus Vaccinia virus EC50 nan None 10.1021/jm901828c
Vaccinia virus Vaccinia virus EC90 nan None 10.1016/j.ejmech.2011.02.014
Vaccinia virus Vaccinia virus IC50 392000.0 nM 10.1016/j.bmc.2008.11.075
Vaccinia virus Vaccinia virus IC50 nan None 10.1021/jm2001426
Vaccinia virus Vaccinia virus MIC 70.0 ug.mL-1 10.1021/jm00066a013
Vaccinia virus Vaccinia virus MIC 80.0 ug.mL-1 10.1021/jm00045a025
Vaccinia virus Vaccinia virus MIC 100.0 ug.mL-1 10.1007/s00044-012-0127-6
Vaccinia virus Vaccinia virus MIC 100.0 ug.mL-1 10.1016/j.ejmech.2007.04.010
Vaccinia virus Vaccinia virus MIC 100.0 ug.mL-1 10.1021/jm010922s
Vaccinia virus Vaccinia virus MIC 150.0 ug.mL-1 10.1021/jm00167a019
Vaccinia virus Vaccinia virus MIC 60000.0 nM 10.1016/j.bmc.2006.10.046
Vaccinia virus Vaccinia virus MIC 100000.0 nM 10.1021/jm070324z
Vaccinia virus Vaccinia virus MIC50 100.0 ug.mL-1 10.1016/j.ejmech.2009.02.030
Vaccinia virus Vaccinia virus MIC50 100.0 ug.mL-1 10.1021/jm050772b
Vaccinia virus Vaccinia virus MIC50 100.0 ug.mL-1 10.1021/jm950891z
Vesicular stomatitis virus Vesicular stomatitis virus Activity nan None 10.1016/j.ejmech.2011.11.021
Vesicular stomatitis virus Vesicular stomatitis virus EC50 100.0 ug.mL-1 10.1016/j.ejmech.2008.08.010
Vesicular stomatitis virus Vesicular stomatitis virus EC50 100.0 ug.mL-1 10.1016/j.ejmech.2009.03.038
Vesicular stomatitis virus Vesicular stomatitis virus EC50 100.0 ug.mL-1 10.1016/j.ejmech.2010.07.058
Vesicular stomatitis virus Vesicular stomatitis virus EC50 100.0 ug.mL-1 10.1016/j.ejmech.2010.09.065
Vesicular stomatitis virus Vesicular stomatitis virus EC50 100.0 ug.mL-1 10.1021/jm025569k
Vesicular stomatitis virus Vesicular stomatitis virus EC50 100000.0 nM 10.1007/s00044-009-9248-y
Vesicular stomatitis virus Vesicular stomatitis virus EC50 100000.0 nM 10.1007/s00044-012-0184-x
Vesicular stomatitis virus Vesicular stomatitis virus EC50 100000.0 nM 10.1016/j.bmcl.2012.09.079
Vesicular stomatitis virus Vesicular stomatitis virus EC50 100000.0 nM 10.1016/j.ejmech.2009.12.002
Vesicular stomatitis virus Vesicular stomatitis virus EC50 100000.0 nM 10.1016/j.ejmech.2012.03.007
Vesicular stomatitis virus Vesicular stomatitis virus EC50 100000.0 nM 10.1016/j.ejmech.2013.05.046
Vesicular stomatitis virus Vesicular stomatitis virus EC50 100000.0 nM 10.1021/jm060030y
Vesicular stomatitis virus Vesicular stomatitis virus EC50 100000.0 nM 10.1021/jm801470b
Vesicular stomatitis virus Vesicular stomatitis virus MIC 100.0 ug.mL-1 10.1007/s00044-012-0127-6
Vesicular stomatitis virus Vesicular stomatitis virus MIC 100.0 ug.mL-1 10.1016/j.ejmech.2007.04.010
Vesicular stomatitis virus Vesicular stomatitis virus MIC 100.0 ug.mL-1 10.1021/jm010922s
Vesicular stomatitis virus Vesicular stomatitis virus MIC 400.0 ug.mL-1 10.1021/jm00066a013
Vesicular stomatitis virus Vesicular stomatitis virus MIC 400.0 ug.mL-1 10.1021/jm00167a019
Vesicular stomatitis virus Vesicular stomatitis virus MIC 100000.0 nM 10.1016/j.bmc.2006.10.046
Vesicular stomatitis virus Vesicular stomatitis virus MIC50 100.0 ug.mL-1 10.1016/j.ejmech.2009.02.030
Vesicular stomatitis virus Vesicular stomatitis virus MIC50 100.0 ug.mL-1 10.1021/jm050772b
Vesicular stomatitis virus Vesicular stomatitis virus MIC50 100.0 ug.mL-1 10.1021/jm950891z
Vesicular stomatitis virus Vesicular stomatitis virus MIC50 nan None 10.1021/jm050772b
None ADMET CC50 100.0 ug.mL-1 10.1016/j.ejmech.2010.07.058
None ADMET CC50 100.0 ug.mL-1 10.1016/j.ejmech.2010.09.065
None ADMET CC50 100.0 ug.mL-1 10.1016/S0960-894X(01)80693-4
None ADMET CC50 5860.0 nM 10.1021/jm800501d
None ADMET CC50 30000.0 nM 10.1016/j.bmcl.2007.01.109
None ADMET CC50 100000.0 nM 10.1007/s00044-012-0184-x
None ADMET CC50 100000.0 nM 10.1016/j.bmc.2008.08.041
None ADMET CC50 100000.0 nM 10.1016/j.ejmech.2009.12.002
None ADMET CC50 100000.0 nM 10.1016/j.ejmech.2012.03.007
None ADMET CC50 100000.0 nM 10.1016/j.ejmech.2012.08.042
None ADMET CC50 100000.0 nM 10.1016/j.ejmech.2013.05.046
None ADMET CC50 100000.0 nM 10.1021/acs.jmedchem.5b00804
None ADMET CC50 100000.0 nM 10.1021/jm801470b
None ADMET CC50 150000.0 nM 10.1021/jm049806q
None ADMET CC50 333000.0 nM 10.1128/aac.01596-09
None ADMET CC50 394000.0 nM 10.1016/j.bmc.2011.04.016
None ADMET CC50 580000.0 nM 10.1016/j.bmc.2010.12.052
None ADMET CL 4.6 mL.min-1.kg-1 10.1124/dmd.108.020479
None ADMET Cytotoxicity 100.0 uM 10.1016/S0960-894X(00)80470-9
None ADMET Drug transport nan None 10.1124/dmd.111.042036
None ADMET EC50 0.019 ug.mL-1 10.1021/jm025569k
None ADMET EC50 2.4 ug.mL-1 10.1021/jm025569k
None ADMET FA 5.0 % 10.1021/jm049711o
None ADMET IC50 1.9 nM 10.1021/jm0610550
None ADMET IC50 18.0 nM 10.1021/jm0610550
None ADMET IC50 33.0 nM 10.1021/jm0610550
None ADMET IC50 41.0 nM 10.1021/jm0610550
None ADMET IC50 50.0 nM 10.1021/jm0610550
None ADMET IC50 81.0 nM 10.1021/jm0610550
None ADMET IC50 100.0 ug.mL-1 10.1021/np9703914
None ADMET IC50 110.0 nM 10.1021/jm0610550
None ADMET IC50 150.0 nM 10.1021/jm070791g
None ADMET IC50 840.0 ug.mL-1 10.1021/np9703914
None ADMET IC50 3000.0 nM 10.1021/jm00122a019
None ADMET IC50 3500.0 nM 10.1021/jm040032n
None ADMET IC50 3500.0 nM 10.1021/jm0400606
None ADMET IC50 3500.0 nM 10.1021/jm990320x
None ADMET IC50 29000.0 nM 10.1021/jm00035a018
None ADMET IC50 100000.0 nM 10.1021/jm00076a011
None ADMET IC50 100000.0 nM 10.1021/jm00081a014
None ADMET IC50 100000.0 nM 10.1021/jm00119a006
None ADMET IC50 100000.0 nM 10.1021/jm00122a019
None ADMET IC50 100000.0 nM 10.1021/jm00127a003
None ADMET IC50 100000.0 nM 10.1021/jm00169a027
None ADMET IC50 100000.0 nM 10.1021/jm00169a028
None ADMET IC50 100000.0 nM 10.1021/jm00174a011
None ADMET IC50 100000.0 nM 10.1021/jm00403a005
None ADMET IC50 100000.0 nM 10.1021/jm0400146
None ADMET IC50 100000.0 nM 10.1021/jm040032n
None ADMET IC50 100000.0 nM 10.1021/jm0400606
None ADMET IC50 100000.0 nM 10.1021/jm070032y
None ADMET IC50 100000.0 nM 10.1021/jm990219s
None ADMET IC50 100000.0 nM 10.1021/jm990290y
None ADMET IC50 100000.0 nM 10.1021/jm990320x
None ADMET IC50 156000.0 nM 10.1021/jm010227k
None ADMET IC50 270000.0 nM 10.1021/jm070791g
None ADMET IC50 1000000.0 nM 10.1021/jm00122a019
None ADMET IC50 1000000.0 nM 10.1021/jm00127a003
None ADMET IC50 1000000.0 nM 10.1021/jm00169a027
None ADMET IC50 1000000.0 nM 10.1021/jm00403a005
None ADMET ID50 75.0 uM 10.1021/jm9806749
None ADMET Inhibition 1000.0 % 10.1021/jm00119a006
None ADMET log10(%HIA +10) 1.134 None 10.1016/j.ejmech.2010.11.005
None ADMET MCC 100000.0 nM 10.1016/j.ejmech.2013.06.036
None ADMET MCC 150000.0 nM 10.1021/jm049806q
None ADMET MCC 1575000.0 nM 10.1016/j.bmc.2010.12.052
None ADMET MCC nan None 10.1021/jm901828c
None ADMET MIC 0.001 ug.mL-1 10.1021/jm991171l
None ADMET MRT 3.7 hr 10.1124/dmd.108.020479
None ADMET NT nan None 10.1016/S0960-894X(97)00368-5
None ADMET Papp 0.23 cm/s * 10E6 10.1021/jm049711o
None ADMET Papp 8.7 cm/s * 10E6 10.1021/jm049711o
None ADMET Papp 97.0 cm/s * 10E6 10.1021/jm049711o
None ADMET permeability 0.7 10'-6 cm/s 10.1021/jm901421c
None ADMET Permeability coefficient 4.88 None 10.1021/jm960163r
None ADMET Ratio 0.09 None 10.1124/dmd.112.046391
None ADMET Ratio 1.85 None 10.1124/dmd.112.046391
None ADMET Ratio CC50/EC50 175.0 None 10.1021/acs.jmedchem.2c00667
None ADMET Ratio CC50/EC50 nan None 10.1021/acs.jmedchem.2c00667
None ADMET Selectivity Index 53.0 None 10.1016/j.ejmech.2021.113640
None ADMET Selectivity Index 54.0 None 10.1021/acs.jmedchem.2c00203
None ADMET Solubility 4300.0 ug.mL-1 10.1021/jm980321+
None ADMET T1/2 3.7 hr 10.1124/dmd.108.020479
None ADMET Therapeutic index 200.0 None 10.1016/S0960-894X(00)80078-5
None ADMET Therapeutic index 500.0 None 10.1016/S0960-894X(00)80078-5
None ADMET TI 20.0 uM 10.1021/jm9802057
None ADMET Vdss 1.0 L.kg-1 10.1124/dmd.108.020479
None CFU-GM IC50 19000.0 nM 10.1021/jm00035a018
None Erythrocyte HC10 20.0 uM 10.6019/CHEMBL4513161
None ESM MIC 0.004 ug.mL-1 10.1021/jm00112a010
None ESM MIC 1.0 ug.mL-1 10.1021/jm00112a010
None ESM MIC 7.0 ug.mL-1 10.1021/jm00112a010
None ESM MIC 20.0 ug.mL-1 10.1021/jm00112a010
None ESM MIC 200.0 ug.mL-1 10.1021/jm00112a010
None ESM MIC 400.0 ug.mL-1 10.1021/jm00112a010
None HEF MIC50 100.0 ug.mL-1 10.1021/jm950891z
None Hepatotoxicity Alkaline Phosphatase Increase - Activity Score nan None 10.2174/1570163043334794
None Hepatotoxicity Alkaline Phosphatase Increase - Index Value 4.2 None 10.2174/1570163043334794
None Hepatotoxicity Alkaline Phosphatase Increase - Number of Reports 4.0 None 10.2174/1570163043334794
None Hepatotoxicity Composite Activity - Active 1.0 None 10.2174/1570163043334794
None Hepatotoxicity Composite Activity - Marginal 0.0 None 10.2174/1570163043334794
None Hepatotoxicity Composite Activity - Score nan None 10.2174/1570163043334794
None Hepatotoxicity GGT Increase - Activity Score nan None 10.2174/1570163043334794
None Hepatotoxicity GGT Increase - Index Value 0.8 None 10.2174/1570163043334794
None Hepatotoxicity GGT Increase - Number of Reports 4.0 None 10.2174/1570163043334794
None Hepatotoxicity Hepatotoxicity nan None 10.1021/tx900326k
None Hepatotoxicity HepSE_bilirubinemia 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_cholecystitis 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_cholelithiasis 1.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_cirrhosis 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_Combined Scores 4.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_elevated liver function tests 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_hepatic failure 1.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_hepatic necrosis 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_hepatitis 1.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_hepatomegaly 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_jaundice 1.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_liver disease 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_liver fatty 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_liver function tests abnormal 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity LDH Increase - Activity Score nan None 10.2174/1570163043334794
None Hepatotoxicity LDH Increase - Index Value 1.9 None 10.2174/1570163043334794
None Hepatotoxicity LDH Increase - Number of Reports 4.0 None 10.2174/1570163043334794
None Hepatotoxicity LTKB_BD DILI severity score 7.0 None 10.1016/j.drudis.2011.05.007
None Hepatotoxicity SGOT Increase - Activity Score nan None 10.2174/1570163043334794
None Hepatotoxicity SGOT Increase - Index Value 2.7 None 10.2174/1570163043334794
None Hepatotoxicity SGOT Increase - Number of Reports 4.0 None 10.2174/1570163043334794
None Hepatotoxicity SGPT Increase - Activity Score nan None 10.2174/1570163043334794
None Hepatotoxicity SGPT Increase - Index Value 2.3 None 10.2174/1570163043334794
None Hepatotoxicity SGPT Increase - Number of Reports 4.0 None 10.2174/1570163043334794
None Molecular identity unknown EC50 0.24 ug.mL-1 10.1021/jm040869i
None Molecular identity unknown EC50 0.34 ug.mL-1 10.1021/jm040869i
None Neutrophil Activity 39.43 % 10.1007/s00044-013-0819-6
None Neutrophil Activity 53.21 % 10.1007/s00044-013-0819-6
None Neutrophil Activity 55.89 % 10.1007/s00044-013-0819-6
None Neutrophil Activity 58.23 % 10.1007/s00044-013-0819-6
None Neutrophil Activity 60.11 % 10.1007/s00044-013-0819-6
None NON-PROTEIN TARGET Activity nan None 10.1016/S0960-894X(97)00325-9
None NON-PROTEIN TARGET CC50 75000.0 nM 10.1021/jm030241s
None NON-PROTEIN TARGET CC50 200000.0 nM 10.1021/jm030241s
None NON-PROTEIN TARGET CC50 300000.0 nM 10.1021/jm030241s
None NON-PROTEIN TARGET EC50 100.0 ug.mL-1 10.1016/j.ejmech.2010.07.058
None NON-PROTEIN TARGET EC50 2100.0 nM 10.1016/j.ejmech.2016.09.014
None NON-PROTEIN TARGET EC50 2100.0 nM 10.1021/jm040149b
None NON-PROTEIN TARGET EC50 5700.0 nM 10.1128/aac.00134-08
None NON-PROTEIN TARGET EC50 100000.0 nM 10.1016/j.ejmech.2012.03.007
None NON-PROTEIN TARGET EC50 nan None 10.1016/j.ejmech.2011.02.014
None NON-PROTEIN TARGET EC90 nan None 10.1016/j.ejmech.2011.02.014
None NON-PROTEIN TARGET Fu 0.99 None 10.1124/dmd.108.020479
None NON-PROTEIN TARGET Hepatotoxicity (acute) 0.0 % 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (animal toxicity known) nan None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (benign tumour) 0.0 None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (granulomatous hepatitis) 0.0 None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (mechanism) nan None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (moderate) 9.0 None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (moderate) 55.0 % 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (time to onset) nan None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET IC50 10.0 ug.mL-1 10.1016/s0960-894x(98)00122-x
None NON-PROTEIN TARGET IC50 117540.0 nM 10.6019/CHEMBL3392926
None NON-PROTEIN TARGET IC50 179440.0 nM 10.6019/CHEMBL3392926
None NON-PROTEIN TARGET IC50 nan None 10.1021/jm2001426
None NON-PROTEIN TARGET ID50 100.0 ug ml-1 10.1021/jm00168a039
None NON-PROTEIN TARGET MCC 100.0 ug.mL-1 10.1021/jm010922s
None NON-PROTEIN TARGET MCC 100.0 ug.mL-1 10.1021/jm960500w
None NON-PROTEIN TARGET MCC 100000.0 nM 10.1016/j.ejmech.2016.09.014
None NON-PROTEIN TARGET MCC 392000.0 nM 10.1021/jm020827z
None NON-PROTEIN TARGET MIC 0.001 ug.mL-1 10.1021/jm991171l
None NON-PROTEIN TARGET MIC 0.003 ug.mL-1 10.1021/jm00045a025
None NON-PROTEIN TARGET MIC 0.004 ug.mL-1 10.1021/jm00045a025
None NON-PROTEIN TARGET MIC 0.02 ug.mL-1 10.1021/jm00045a025
None NON-PROTEIN TARGET MIC 0.04 ug.mL-1 10.1021/jm00045a025
None NON-PROTEIN TARGET MIC 0.48 ug.mL-1 10.1021/jm991171l
None NON-PROTEIN TARGET MIC 30.0 nM 10.1021/jm020827z
None NON-PROTEIN TARGET MIC 40.0 nM 10.1021/jm020827z
None NON-PROTEIN TARGET MIC 45.0 nM 10.1021/jm020827z
None NON-PROTEIN TARGET MIC 60.0 nM 10.1021/jm020827z
None NON-PROTEIN TARGET MIC 100.0 nM 10.1021/jm020827z
None NON-PROTEIN TARGET MIC 7500.0 nM 10.1021/jm020827z
None NON-PROTEIN TARGET Potency 0.7 nM None
None NON-PROTEIN TARGET Potency 3.8 nM None
None NON-PROTEIN TARGET Potency 595.2 nM None
None NON-PROTEIN TARGET Selectivity index 200.0 None 10.1021/jm981051y
None No relevant target LogP -8.1 None 10.1021/jm010289a
None No relevant target LogP -3.0 None 10.1021/jm010289a
None No relevant target LogP -2.07 None 10.1021/jm010289a
None No relevant target Solubility 2000.0 ug.mL-1 10.1021/acs.jmedchem.1c00790
None No relevant target Solubility 4960.0 ug.mL-1 10.1021/acs.jmedchem.5b00804
None Nucleic Acid BPR 0.1 None 10.1124/dmd.112.046391
None Nucleic Acid EC50 1.5 ug.mL-1 10.1016/s0960-894x(01)00589-3
None Nucleic Acid Ratio 0.05 None 10.1124/dmd.112.046391
None Osteoclast-like IC50 30000.0 nM 10.1016/j.bmcl.2006.06.066
None Unchecked Ac50 0.2818 uM None
None Unchecked Ac50 0.7079 uM None
None Unchecked Ac50 10.0 uM None
None Unchecked Ac50 19.95 uM None
None Unchecked AC50 290.0 nM None
None Unchecked AC50 707.9 nM None
None Unchecked AC50 10000.0 nM None
None Unchecked AC50 19952.6 nM None
None Unchecked CC50 75000.0 nM 10.1021/jm030241s
None Unchecked CC50 100000.0 nM 10.1016/j.bmc.2015.12.008
None Unchecked CC50 350000.0 nM 10.1016/j.ejmech.2019.111739
None Unchecked CC50 nan None 10.1016/j.ejmech.2018.07.062
None Unchecked EC50 0.019 ug.mL-1 10.1021/jm025569k
None Unchecked EC50 0.032 ug.mL-1 10.1021/jm025569k
None Unchecked EC50 200.0 nM 10.1016/j.bmc.2015.12.008
None Unchecked EC50 500.0 nM 10.1016/j.bmc.2015.12.008
None Unchecked EC50 900.0 nM 10.1039/d1md00086a
None Unchecked EC50 930.0 nM 10.1016/j.ejmech.2021.113640
None Unchecked EC50 960.0 nM 10.1021/acs.jmedchem.9b01501
None Unchecked EC50 1670.0 nM 10.1021/acsmedchemlett.0c00485
None Unchecked EC50 2600.0 nM 10.1016/j.bmcl.2020.127514
None Unchecked EC50 2770.0 nM 10.1021/acsmedchemlett.0c00485
None Unchecked EC90 74.2 uM 10.1039/d1md00086a
None Unchecked Hepatotoxicity (acute) 1.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (association with vascular disease) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (choleostasis) 1.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (chronic liver disease) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (cirrhosis) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (comment) nan None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (cytolytic) 1.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (malignant tumour) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (severe hepatitis) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (steatosis) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (successful reintroduction) nan None 10.1016/s0399-8320(04)95062-2
None Unchecked IC50 1300.0 nM 10.1016/j.bmcl.2010.03.115
None Unchecked IC50 nan None None
None Unchecked Inhibition 22.0 % 10.1021/jm00120a010
None Unchecked Inhibition nan % 10.1016/S0960-894X(97)00325-9
None Unchecked Inhibition nan % 10.1038/nchembio873
None Unchecked Ki nan None None
None Unchecked MCC 100000.0 nM 10.1016/j.ejmech.2018.07.062
None Unchecked MCC 250000.0 nM 10.1016/j.ejmech.2019.111739
None Unchecked MCC nan None 10.1016/j.ejmech.2022.114857
None Unchecked Papp 6.7 cm/s * 10E6 10.1021/jm049711o
None Unchecked Potency 125.9 nM None
None Unchecked Ratio CC50/EC50 175.0 None 10.1039/d1md00086a
None Unchecked Ratio CC50/EC50 289.0 None 10.1128/aac.00988-08
None Unchecked Ratio CC50/IC50 1100.0 None 10.1016/j.bmcl.2006.12.085
None Unchecked Ratio EC50 100.0 None 10.1021/ml2001054
None Unchecked Ratio IC50/EC50 20.0 None 10.1021/np9703914
None Unchecked Ratio IC50/EC50 74.0 None 10.1021/np9703914
None Unchecked Selectivity Index 139.0 None 10.1128/aac.01596-09
None Unchecked Selectivity Index 161.0 None 10.1128/aac.01596-09
None Unchecked Selectivity Index 174.0 None 10.1128/aac.01596-09
None Unchecked Selectivity Index 202.0 None 10.1128/aac.01596-09
None Unchecked Selectivity Index 289.0 None 10.1128/aac.01730-09
None Unchecked Selectivity Index 1044.0 None 10.1128/aac.01596-09
None Unchecked Selectivity Index 2500.0 None 10.1016/j.ejmech.2011.02.014
None Unchecked Selectivity Index nan None 10.1016/j.ejmech.2011.02.014

Metabolism Information

AKRT ID Reaction Reaction Link ID
AKRT002614 CC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)OCC(CO)OCn1cnc2c(=O)[nH]c(=N)[nH]c21>>N=c1[nH]c(=O)c2ncn(COC(CO)CO)c2[nH]1 enzymemap_71568
AKRT006302 CC(C)[C@H](N)C(=O)O.Nc1nc2c(ncn2COC(CO)CO)c(=O)[nH]1>>CC(C)[C@H](N)C(=O)OCC(CO)OCn1cnc2c(=O)nc(N)[nH]c21 MNXR141772
AKRT006334 CC(C)[C@H](N)C(=O)OCC(CO)OCn1cnc2c(=O)[nH]c(=N)[nH]c21>>N=c1[nH]c(=O)c2ncn(COC(CO)CO)c2[nH]1 enzymemap_52924
AKRT006336 CC(C)[C@H](N)C(=O)OCC(CO)OCn1cnc2c(=O)[nH]c(N)nc21>>Nc1nc2c(ncn2COC(CO)CO)c(=O)[nH]1 enzymemap_52924
AKRT016374 N=c1[nH]c(=O)c2ncn(COC(CO)CO)c2[nH]1>>N=c1[nH]c(=O)c2ncn(COC(CO)COP(=O)(O)O)c2[nH]1 enzymemap_43254
AKRT016764 N=c1nc(O)c2ncn(COC(CO)CO)c2[nH]1>>Nc1nc2c(ncn2COC(CO)CO)c(=O)[nH]1 MNXR133496
AKRT021260 Nc1nc2c(ncn2COC(CO)CO)c(=O)[nH]1>>Nc1nc2c(ncn2COC(CO)COP(=O)(O)O)c(=O)[nH]1 enzymemap_43254