Navigation

name Structure Reference Source Properties Activities Metabolism

6-[2-carboxy-2-(thiophen-3-yl)acetamido]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid

AlkaPlorer ID: AK019614

Synonym: None

IUPAC Name: (2S,5R,6R)-6-[[(2R)-2-carboxy-2-thiophen-3-ylacetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid

Structure

SMILES: CC1(C)S[C@@H]2[C@H](N=C(O)[C@H](C(=O)O)C3=CSC=C3)C(=O)N2[C@H]1C(=O)O

copy

InChI: InChI=1S/C15H16N2O6S2/c1-15(2)9(14(22)23)17-11(19)8(12(17)25-15)16-10(18)7(13(20)21)6-3-4-24-5-6/h3-5,7-9,12H,1-2H3,(H,16,18)(H,20,21)(H,22,23)/t7-,8-,9+,12-/m1/s1

copy

InChIKey: OHKOGUYZJXTSFX-KZFFXBSXSA-N

copy

Source

Species Genus Family Order Class Phylum Kingdom Domain

Properties Information

Molecule Weight: 384.4350000000001

TPSA？: 127.5

MolLogP？: 1.3883

Number of H-Donors: 3

Number of H-Acceptors: 6

RingCount: 3

Activities Information

Organism Target Name Standard Type Standard Value Standard Units doi
Acinetobacter Acinetobacter MIC 256.0 ug.mL-1 10.1128/aac.01115-07
Acinetobacter Acinetobacter MIC nan None 10.1128/aac.01115-07
Acinetobacter baumannii Acinetobacter baumannii MIC 1.0 ug.mL-1 10.1128/aac.00732-07
Acinetobacter baumannii Acinetobacter baumannii MIC 2.0 ug.mL-1 10.1128/aac.01037-09
Acinetobacter baumannii Acinetobacter baumannii MIC 4.0 ug.mL-1 10.1128/aac.00856-09
Acinetobacter baumannii Acinetobacter baumannii MIC 4.0 ug.mL-1 10.1128/aac.00978-07
Acinetobacter baumannii Acinetobacter baumannii MIC 6.0 ug.mL-1 10.1128/aac.01037-09
Acinetobacter baumannii Acinetobacter baumannii MIC 8.0 ug.mL-1 10.1039/C5MD00377F
Acinetobacter baumannii Acinetobacter baumannii MIC 8.0 ug.mL-1 10.1128/aac.00050-10
Acinetobacter baumannii Acinetobacter baumannii MIC 8.0 ug.mL-1 10.1128/aac.00393-08
Acinetobacter baumannii Acinetobacter baumannii MIC 8.0 ug.mL-1 10.1128/aac.00732-07
Acinetobacter baumannii Acinetobacter baumannii MIC 8.0 ug.mL-1 10.1128/aac.01037-09
Acinetobacter baumannii Acinetobacter baumannii MIC 8.0 ug.mL-1 10.1128/aac.01164-08
Acinetobacter baumannii Acinetobacter baumannii MIC 12.0 ug.mL-1 10.1128/aac.01037-09
Acinetobacter baumannii Acinetobacter baumannii MIC 16.0 ug.mL-1 10.1128/aac.00393-08
Acinetobacter baumannii Acinetobacter baumannii MIC 16.0 ug.mL-1 10.1128/aac.01037-09
Acinetobacter baumannii Acinetobacter baumannii MIC 24.0 ug.mL-1 10.1128/aac.01037-09
Acinetobacter baumannii Acinetobacter baumannii MIC 32.0 ug.mL-1 10.1039/C5MD00377F
Acinetobacter baumannii Acinetobacter baumannii MIC 32.0 ug.mL-1 10.1128/aac.01407-08
Acinetobacter baumannii Acinetobacter baumannii MIC 64.0 ug.mL-1 10.1039/C5MD00377F
Acinetobacter baumannii Acinetobacter baumannii MIC 64.0 ug.mL-1 10.1128/aac.00050-10
Acinetobacter baumannii Acinetobacter baumannii MIC 64.0 ug.mL-1 10.1128/aac.00978-07
Acinetobacter baumannii Acinetobacter baumannii MIC 128.0 ug.mL-1 10.1128/aac.00050-10
Acinetobacter baumannii Acinetobacter baumannii MIC 128.0 ug.mL-1 10.1128/aac.00838-06
Acinetobacter baumannii Acinetobacter baumannii MIC 256.0 ug.mL-1 10.1128/aac.00050-10
Acinetobacter baumannii Acinetobacter baumannii MIC 256.0 ug.mL-1 10.1128/aac.00267-07
Acinetobacter baumannii Acinetobacter baumannii MIC 256.0 ug.mL-1 10.1128/aac.00393-08
Acinetobacter baumannii Acinetobacter baumannii MIC 256.0 ug.mL-1 10.1128/aac.00732-07
Acinetobacter baumannii Acinetobacter baumannii MIC 256.0 ug.mL-1 10.1128/aac.00856-09
Acinetobacter baumannii Acinetobacter baumannii MIC 256.0 ug.mL-1 10.1128/aac.00861-09
Acinetobacter baumannii Acinetobacter baumannii MIC 256.0 ug.mL-1 10.1128/aac.01037-09
Acinetobacter baumannii Acinetobacter baumannii MIC 256.0 ug.mL-1 10.1128/aac.01164-08
Acinetobacter baumannii Acinetobacter baumannii MIC 512.0 ug.mL-1 10.1128/aac.00978-07
Acinetobacter baumannii Acinetobacter baumannii MIC 1024.0 ug.mL-1 10.1128/aac.00393-08
Acinetobacter haemolyticus Acinetobacter haemolyticus MIC 256.0 ug.mL-1 10.1128/aac.00267-07
Acinetobacter radioresistens Acinetobacter radioresistens MIC 4.0 ug.mL-1 10.1128/aac.00999-08
Acinetobacter radioresistens Acinetobacter radioresistens MIC 256.0 ug.mL-1 10.1128/aac.00999-08
Acinetobacter sp. Acinetobacter sp. MIC 128.0 ug.mL-1 10.1128/aac.00838-06
Aeromonas allosaccharophila Extended-spectrum beta-lactamase PER-6 Kcat 0.4 /s 10.1128/aac.01585-09
Aeromonas allosaccharophila Extended-spectrum beta-lactamase PER-6 Kcat/Km 50.0 /uM/s 10.1128/aac.01585-09
Aeromonas allosaccharophila Extended-spectrum beta-lactamase PER-6 Km 9000.0 nM 10.1128/aac.01585-09
Aeromonas caviae Aeromonas caviae MIC 2048.0 ug.mL-1 10.1128/aac.01462-06
Aeromonas caviae IMP-19 Kcat 683.0 /s 10.1128/aac.01462-06
Aeromonas caviae IMP-19 Kcat/Km 4.88 None 10.1128/aac.01462-06
Aeromonas caviae IMP-19 Km 140000.0 nM 10.1128/aac.01462-06
Aeromonas sp. Aeromonas sp. MIC 128.0 ug.mL-1 10.1128/aac.00770-08
Aeromonas sp. Aeromonas sp. MIC 256.0 ug.mL-1 10.1128/aac.00770-08
Bacillus clausii Beta-lactamase Activity 12.0 None 10.1128/aac.00537-07
Bacillus clausii Beta-lactamase Kcat 5.0 /s 10.1128/aac.00537-07
Bacillus clausii Beta-lactamase Kcat/Km 1.0 /uM/s 10.1128/aac.00537-07
Bacillus clausii Beta-lactamase Km 6000.0 nM 10.1128/aac.00537-07
Burkholderia cenocepacia Burkholderia cenocepacia MIC 512.0 ug.mL-1 10.1128/aac.00946-08
Burkholderia cenocepacia PenB class A beta-lactamase Kcat 15.0 /s 10.1128/aac.00946-08
Burkholderia cenocepacia PenB class A beta-lactamase Kcat/Km 250.0 /uM/s 10.1128/aac.00946-08
Burkholderia cenocepacia PenB class A beta-lactamase Km 60000.0 nM 10.1128/aac.00946-08
Burkholderia cepacia Burkholderia cepacia Activity 2.0 % 10.1128/aac.00954-06
Campylobacter coli Campylobacter coli MIC 8.0 ug.mL-1 10.1128/aac.01655-08
Campylobacter coli Campylobacter coli MIC 32.0 ug.mL-1 10.1128/aac.01655-08
Campylobacter coli Campylobacter coli MIC 64.0 ug.mL-1 10.1128/aac.01655-08
Campylobacter coli Campylobacter coli MIC50 64.0 ug.mL-1 10.1128/aac.01655-08
Campylobacter coli Campylobacter coli MIC90 128.0 ug.mL-1 10.1128/aac.01655-08
Campylobacter jejuni Campylobacter jejuni MIC 2.0 ug.mL-1 10.1128/aac.01655-08
Campylobacter jejuni Campylobacter jejuni MIC 4.0 ug.mL-1 10.1128/aac.01655-08
Campylobacter jejuni Campylobacter jejuni MIC 8.0 ug.mL-1 10.1128/aac.01655-08
Campylobacter jejuni Campylobacter jejuni MIC 32.0 ug.mL-1 10.1128/aac.01655-08
Campylobacter jejuni Campylobacter jejuni MIC 64.0 ug.mL-1 10.1128/aac.01655-08
Campylobacter jejuni Campylobacter jejuni MIC 128.0 ug.mL-1 10.1128/aac.01655-08
Campylobacter jejuni Campylobacter jejuni MIC50 64.0 ug.mL-1 10.1128/aac.01655-08
Campylobacter jejuni Campylobacter jejuni MIC90 128.0 ug.mL-1 10.1128/aac.01655-08
Carnobacterium divergens Carnobacterium divergens MIC 24.0 ug.mL-1 10.1128/aac.01145-07
Carnobacterium divergens Carnobacterium divergens MIC 32.0 ug.mL-1 10.1128/aac.01145-07
Carnobacterium divergens Carnobacterium divergens MIC 128.0 ug.mL-1 10.1128/aac.01145-07
Carnobacterium divergens Carnobacterium divergens MIC nan None 10.1128/aac.01145-07
Chryseobacterium indologenes Chryseobacterium indologenes MIC nan None 10.1128/aac.01607-08
Citrobacter freundii Citrobacter freundii MIC 512.0 ug.mL-1 10.1128/aac.01312-09
Citrobacter freundii Citrobacter freundii MIC 512.0 ug.mL-1 10.1128/aac.01337-07
Citrobacter gillenii Gil1 Kcat 100.0 /s 10.1128/aac.01152-06
Citrobacter gillenii Gil1 Kcat/Km 10000.0 /mM/s 10.1128/aac.01152-06
Citrobacter gillenii Gil1 Km 10000.0 nM 10.1128/aac.01152-06
Citrobacter gillenii Gil1 Ratio 180.0 None 10.1128/aac.01152-06
Dialister invisus Dialister invisus Activity 16.0 ug ml-1 10.1128/aac.00538-07
Dialister invisus Dialister invisus Activity 32.0 ug ml-1 10.1128/aac.00538-07
Dialister invisus Dialister invisus MIC 0.25 ug.mL-1 10.1128/aac.00538-07
Dialister micraerophilus Dialister micraerophilus Activity 16.0 ug ml-1 10.1128/aac.00538-07
Dialister micraerophilus Dialister micraerophilus Activity 32.0 ug ml-1 10.1128/aac.00538-07
Dialister micraerophilus Dialister micraerophilus MIC 0.06 ug.mL-1 10.1128/aac.00538-07
Dialister micraerophilus Dialister micraerophilus MIC50 0.06 ug.mL-1 10.1128/aac.00538-07
Dialister micraerophilus Dialister micraerophilus MIC90 0.5 ug.mL-1 10.1128/aac.00538-07
Dialister pneumosintes Dialister pneumosintes Activity 16.0 ug ml-1 10.1128/aac.00538-07
Dialister pneumosintes Dialister pneumosintes Activity 32.0 ug ml-1 10.1128/aac.00538-07
Dialister pneumosintes Dialister pneumosintes MIC 0.06 ug.mL-1 10.1128/aac.00538-07
Dialister pneumosintes Dialister pneumosintes MIC50 0.25 ug.mL-1 10.1128/aac.00538-07
Dialister pneumosintes Dialister pneumosintes MIC90 2.0 ug.mL-1 10.1128/aac.00538-07
Dialister propionicifaciens Dialister propionicifaciens Activity 16.0 ug ml-1 10.1128/aac.00538-07
Dialister propionicifaciens Dialister propionicifaciens Activity 32.0 ug ml-1 10.1128/aac.00538-07
Dialister propionicifaciens Dialister propionicifaciens MIC 0.06 ug.mL-1 10.1128/aac.00538-07
Elizabethkingia meningoseptica GOB-1 metallo-beta-lactamase Kcat/Km 5.2 10'5/M/s 10.1128/aac.01062-07
Enterobacter Enterobacter MIC 256.0 ug.mL-1 10.1128/aac.01614-06
Enterobacter cloacae Enterobacter cloacae MIC 256.0 ug.mL-1 10.1128/aac.00163-08
Enterobacter cloacae Enterobacter cloacae MIC 512.0 ug.mL-1 10.1128/aac.01082-06
Enterobacter cloacae Enterobacter cloacae MIC 512.0 ug.mL-1 10.1128/aac.01312-09
Escherichia coli Beta-lactamase SHV-1 Kcat 220.0 /s 10.1128/aac.01442-09
Escherichia coli Beta-lactamase SHV-1 Kcat/Km 20.0 /uM/s 10.1128/aac.01442-09
Escherichia coli Beta-lactamase SHV-1 Km 11000.0 nM 10.1128/aac.01442-09
Escherichia coli Beta-lactamase SHV-11 Kcat 2.0 /s 10.1128/aac.00387-08
Escherichia coli Beta-lactamase SHV-11 Kcat/Km 100.0 /uM/s 10.1128/aac.00387-08
Escherichia coli Beta-lactamase SHV-11 Km 20000.0 nM 10.1128/aac.00387-08
Escherichia coli Beta-lactamase TEM Kcat 135.0 /s 10.1128/aac.00614-07
Escherichia coli Beta-lactamase TEM Kcat/Km 3.8 None 10.1128/aac.00614-07
Escherichia coli Beta-lactamase TEM Km 36.0 /s/microM 10.1128/aac.00614-07
Escherichia coli BlaVIM-1 Kcat nan None 10.1128/aac.00017-09
Escherichia coli CMT-type beta lactamase Kcat 4.2 /s 10.1128/aac.00614-07
Escherichia coli CMT-type beta lactamase Kcat/Km 0.029 None 10.1128/aac.00614-07
Escherichia coli CMT-type beta lactamase Km 142.6 /s/microM 10.1128/aac.00614-07
Escherichia coli Escherichia coli Activity 100.0 % 10.1128/aac.01412-06
Escherichia coli Escherichia coli Activity nan None 10.1128/aac.00614-07
Escherichia coli Escherichia coli MIC 0.75 ug.mL-1 10.1128/aac.01145-07
Escherichia coli Escherichia coli MIC 1.0 ug.mL-1 10.1128/aac.00219-09
Escherichia coli Escherichia coli MIC 1.0 ug.mL-1 10.1128/aac.00608-08
Escherichia coli Escherichia coli MIC 1.0 ug.mL-1 10.1128/aac.00791-09
Escherichia coli Escherichia coli MIC 1.0 ug.mL-1 10.1128/aac.01152-06
Escherichia coli Escherichia coli MIC 1.5 ug.mL-1 10.1128/aac.00163-08
Escherichia coli Escherichia coli MIC 1.5 ug.mL-1 10.1128/aac.00771-10
Escherichia coli Escherichia coli MIC 1.5 ug.mL-1 10.1128/aac.01451-07
Escherichia coli Escherichia coli MIC 2.0 ug.mL-1 10.1128/aac.00017-09
Escherichia coli Escherichia coli MIC 2.0 ug.mL-1 10.1128/aac.00050-10
Escherichia coli Escherichia coli MIC 2.0 ug.mL-1 10.1128/aac.00219-09
Escherichia coli Escherichia coli MIC 2.0 ug.mL-1 10.1128/aac.00387-08
Escherichia coli Escherichia coli MIC 2.0 ug.mL-1 10.1128/aac.00427-09
Escherichia coli Escherichia coli MIC 2.0 ug.mL-1 10.1128/aac.00543-08
Escherichia coli Escherichia coli MIC 2.0 ug.mL-1 10.1128/aac.00608-08
Escherichia coli Escherichia coli MIC 2.0 ug.mL-1 10.1128/aac.00614-07
Escherichia coli Escherichia coli MIC 2.0 ug.mL-1 10.1128/aac.01058-06
Escherichia coli Escherichia coli MIC 2.0 ug.mL-1 10.1128/aac.01164-08
Escherichia coli Escherichia coli MIC 2.0 ug.mL-1 10.1128/aac.01180-07
Escherichia coli Escherichia coli MIC 2.0 ug.mL-1 10.1128/aac.01284-08
Escherichia coli Escherichia coli MIC 2.0 ug.mL-1 10.1128/aac.01312-09
Escherichia coli Escherichia coli MIC 2.0 ug.mL-1 10.1128/aac.01337-07
Escherichia coli Escherichia coli MIC 2.0 ug.mL-1 10.1128/aac.01439-06
Escherichia coli Escherichia coli MIC 2.0 ug.mL-1 10.1128/aac.01442-09
Escherichia coli Escherichia coli MIC 2.0 ug.mL-1 10.1128/aac.01451-07
Escherichia coli Escherichia coli MIC 2.0 ug.mL-1 10.1128/aac.01463-07
Escherichia coli Escherichia coli MIC 2.0 ug.mL-1 10.1128/aac.01561-09
Escherichia coli Escherichia coli MIC 2.0 ug.mL-1 10.1128/aac.01581-08
Escherichia coli Escherichia coli MIC 2.0 ug.mL-1 10.1128/aac.01600-06
Escherichia coli Escherichia coli MIC 4.0 ug.mL-1 10.1128/aac.00387-08
Escherichia coli Escherichia coli MIC 4.0 ug.mL-1 10.1128/aac.00458-09
Escherichia coli Escherichia coli MIC 4.0 ug.mL-1 10.1128/aac.00638-08
Escherichia coli Escherichia coli MIC 4.0 ug.mL-1 10.1128/aac.00770-08
Escherichia coli Escherichia coli MIC 4.0 ug.mL-1 10.1128/aac.00771-10
Escherichia coli Escherichia coli MIC 4.0 ug.mL-1 10.1128/aac.00856-09
Escherichia coli Escherichia coli MIC 4.0 ug.mL-1 10.1128/aac.00859-09
Escherichia coli Escherichia coli MIC 4.0 ug.mL-1 10.1128/aac.00878-10
Escherichia coli Escherichia coli MIC 4.0 ug.mL-1 10.1128/aac.00946-08
Escherichia coli Escherichia coli MIC 4.0 ug.mL-1 10.1128/aac.00961-09
Escherichia coli Escherichia coli MIC 4.0 ug.mL-1 10.1128/aac.01062-07
Escherichia coli Escherichia coli MIC 4.0 ug.mL-1 10.1128/aac.01082-06
Escherichia coli Escherichia coli MIC 4.0 ug.mL-1 10.1128/aac.01252-09
Escherichia coli Escherichia coli MIC 4.0 ug.mL-1 10.1128/aac.01312-09
Escherichia coli Escherichia coli MIC 4.0 ug.mL-1 10.1128/aac.01337-07
Escherichia coli Escherichia coli MIC 4.0 ug.mL-1 10.1128/aac.01381-07
Escherichia coli Escherichia coli MIC 4.0 ug.mL-1 10.1128/aac.01412-06
Escherichia coli Escherichia coli MIC 4.0 ug.mL-1 10.1128/aac.01456-09
Escherichia coli Escherichia coli MIC 4.0 ug.mL-1 10.1128/aac.01462-06
Escherichia coli Escherichia coli MIC 4.0 ug.mL-1 10.1128/aac.01463-07
Escherichia coli Escherichia coli MIC 4.0 ug.mL-1 10.1128/aac.01472-06
Escherichia coli Escherichia coli MIC 4.0 ug.mL-1 10.1128/aac.01581-08
Escherichia coli Escherichia coli MIC 4.0 ug.mL-1 10.1128/aac.01585-09
Escherichia coli Escherichia coli MIC 4.0 ug.mL-1 10.1128/aac.01607-08
Escherichia coli Escherichia coli MIC 4.0 ug.mL-1 10.1128/aac.01672-07
Escherichia coli Escherichia coli MIC 6.0 ug.mL-1 10.1128/aac.00771-10
Escherichia coli Escherichia coli MIC 8.0 ug.mL-1 10.1128/aac.00050-10
Escherichia coli Escherichia coli MIC 8.0 ug.mL-1 10.1128/aac.00393-08
Escherichia coli Escherichia coli MIC 8.0 ug.mL-1 10.1128/aac.00770-08
Escherichia coli Escherichia coli MIC 8.0 ug.mL-1 10.1128/aac.00771-10
Escherichia coli Escherichia coli MIC 8.0 ug.mL-1 10.1128/aac.00858-10
Escherichia coli Escherichia coli MIC 8.0 ug.mL-1 10.1128/aac.01062-07
Escherichia coli Escherichia coli MIC 8.0 ug.mL-1 10.1128/aac.01381-07
Escherichia coli Escherichia coli MIC 8.0 ug.mL-1 10.1128/aac.01472-06
Escherichia coli Escherichia coli MIC 8.0 ug.mL-1 10.1128/aac.01581-08
Escherichia coli Escherichia coli MIC 12.0 ug.mL-1 10.1128/aac.01585-09
Escherichia coli Escherichia coli MIC 16.0 ug.mL-1 10.1128/aac.00427-09
Escherichia coli Escherichia coli MIC 16.0 ug.mL-1 10.1128/aac.00771-10
Escherichia coli Escherichia coli MIC 16.0 ug.mL-1 10.1128/aac.00896-08
Escherichia coli Escherichia coli MIC 16.0 ug.mL-1 10.1128/aac.01164-08
Escherichia coli Escherichia coli MIC 16.0 ug.mL-1 10.1128/aac.01561-09
Escherichia coli Escherichia coli MIC 16.0 ug.mL-1 10.1128/aac.01585-09
Escherichia coli Escherichia coli MIC 32.0 ug.mL-1 10.1128/aac.01561-09
Escherichia coli Escherichia coli MIC 32.0 ug.mL-1 10.1128/aac.01581-08
Escherichia coli Escherichia coli MIC 64.0 ug.mL-1 10.1128/aac.00050-10
Escherichia coli Escherichia coli MIC 64.0 ug.mL-1 10.1128/aac.00608-08
Escherichia coli Escherichia coli MIC 64.0 ug.mL-1 10.1128/aac.00896-08
Escherichia coli Escherichia coli MIC 64.0 ug.mL-1 10.1128/aac.01252-09
Escherichia coli Escherichia coli MIC 128.0 ug.mL-1 10.1128/aac.00050-10
Escherichia coli Escherichia coli MIC 128.0 ug.mL-1 10.1128/aac.00387-08
Escherichia coli Escherichia coli MIC 128.0 ug.mL-1 10.1128/aac.00856-09
Escherichia coli Escherichia coli MIC 128.0 ug.mL-1 10.1128/aac.00961-09
Escherichia coli Escherichia coli MIC 128.0 ug.mL-1 10.1128/aac.01312-09
Escherichia coli Escherichia coli MIC 256.0 ug.mL-1 10.1128/aac.00050-10
Escherichia coli Escherichia coli MIC 256.0 ug.mL-1 10.1128/aac.00163-08
Escherichia coli Escherichia coli MIC 256.0 ug.mL-1 10.1128/aac.00387-08
Escherichia coli Escherichia coli MIC 256.0 ug.mL-1 10.1128/aac.00393-08
Escherichia coli Escherichia coli MIC 256.0 ug.mL-1 10.1128/aac.00427-09
Escherichia coli Escherichia coli MIC 256.0 ug.mL-1 10.1128/aac.00543-08
Escherichia coli Escherichia coli MIC 256.0 ug.mL-1 10.1128/aac.00608-08
Escherichia coli Escherichia coli MIC 256.0 ug.mL-1 10.1128/aac.00638-08
Escherichia coli Escherichia coli MIC 256.0 ug.mL-1 10.1128/aac.00770-08
Escherichia coli Escherichia coli MIC 256.0 ug.mL-1 10.1128/aac.00771-10
Escherichia coli Escherichia coli MIC 256.0 ug.mL-1 10.1128/aac.00858-10
Escherichia coli Escherichia coli MIC 256.0 ug.mL-1 10.1128/aac.00961-09
Escherichia coli Escherichia coli MIC 256.0 ug.mL-1 10.1128/aac.01145-07
Escherichia coli Escherichia coli MIC 256.0 ug.mL-1 10.1128/aac.01164-08
Escherichia coli Escherichia coli MIC 256.0 ug.mL-1 10.1128/aac.01180-07
Escherichia coli Escherichia coli MIC 256.0 ug.mL-1 10.1128/aac.01284-08
Escherichia coli Escherichia coli MIC 256.0 ug.mL-1 10.1128/aac.01312-09
Escherichia coli Escherichia coli MIC 256.0 ug.mL-1 10.1128/aac.01439-06
Escherichia coli Escherichia coli MIC 256.0 ug.mL-1 10.1128/aac.01451-07
Escherichia coli Escherichia coli MIC 256.0 ug.mL-1 10.1128/aac.01581-08
Escherichia coli Escherichia coli MIC 256.0 ug.mL-1 10.1128/aac.01585-09
Escherichia coli Escherichia coli MIC 256.0 ug.mL-1 10.1128/aac.01607-08
Escherichia coli Escherichia coli MIC 512.0 ug.mL-1 10.1128/aac.00219-09
Escherichia coli Escherichia coli MIC 512.0 ug.mL-1 10.1128/aac.00458-09
Escherichia coli Escherichia coli MIC 512.0 ug.mL-1 10.1128/aac.00791-09
Escherichia coli Escherichia coli MIC 512.0 ug.mL-1 10.1128/aac.00858-10
Escherichia coli Escherichia coli MIC 512.0 ug.mL-1 10.1128/aac.00859-09
Escherichia coli Escherichia coli MIC 512.0 ug.mL-1 10.1128/aac.00878-10
Escherichia coli Escherichia coli MIC 512.0 ug.mL-1 10.1128/aac.00946-08
Escherichia coli Escherichia coli MIC 512.0 ug.mL-1 10.1128/aac.00978-07
Escherichia coli Escherichia coli MIC 512.0 ug.mL-1 10.1128/aac.01082-06
Escherichia coli Escherichia coli MIC 512.0 ug.mL-1 10.1128/aac.01152-06
Escherichia coli Escherichia coli MIC 512.0 ug.mL-1 10.1128/aac.01312-09
Escherichia coli Escherichia coli MIC 512.0 ug.mL-1 10.1128/aac.01337-07
Escherichia coli Escherichia coli MIC 512.0 ug.mL-1 10.1128/aac.01456-09
Escherichia coli Escherichia coli MIC 512.0 ug.mL-1 10.1128/aac.01462-06
Escherichia coli Escherichia coli MIC 512.0 ug.mL-1 10.1128/aac.01561-09
Escherichia coli Escherichia coli MIC 512.0 ug.mL-1 10.1128/aac.01600-06
Escherichia coli Escherichia coli MIC 512.0 ug.mL-1 10.1128/aac.01672-07
Escherichia coli Escherichia coli MIC 514.0 ug.mL-1 10.1128/aac.01672-07
Escherichia coli Escherichia coli MIC 515.0 ug.mL-1 10.1128/aac.01672-07
Escherichia coli Escherichia coli MIC 1000.0 ug.mL-1 10.1128/aac.00537-07
Escherichia coli Escherichia coli MIC 1024.0 ug.mL-1 10.1128/aac.00393-08
Escherichia coli Escherichia coli MIC 1024.0 ug.mL-1 10.1128/aac.01381-07
Escherichia coli Escherichia coli MIC 1024.0 ug.mL-1 10.1128/aac.01442-09
Escherichia coli Escherichia coli MIC 1024.0 ug.mL-1 10.1128/aac.01462-06
Escherichia coli Escherichia coli MIC 2048.0 ug.mL-1 10.1128/aac.00017-09
Escherichia coli Escherichia coli MIC 2048.0 ug.mL-1 10.1128/aac.00387-08
Escherichia coli Escherichia coli MIC 2048.0 ug.mL-1 10.1128/aac.00614-07
Escherichia coli Escherichia coli MIC 2048.0 ug.mL-1 10.1128/aac.01058-06
Escherichia coli Escherichia coli MIC 4096.0 ug.mL-1 10.1128/aac.00387-08
Escherichia coli Escherichia coli MIC 4096.0 ug.mL-1 10.1128/aac.01412-06
Escherichia coli Escherichia coli MIC 4096.0 ug.mL-1 10.1128/aac.01442-09
Escherichia coli Escherichia coli MIC 8000.0 ug.mL-1 10.1128/aac.00537-07
Escherichia coli Escherichia coli MIC 512000.0 ug.mL-1 10.1128/aac.00537-07
Escherichia coli Escherichia coli MIC50 64.0 ug.mL-1 10.1128/aac.01412-06
Escherichia coli Escherichia coli MIC90 64.0 ug.mL-1 10.1128/aac.01412-06
Escherichia coli Metallo-beta-lactamase Kcat 31.7 /s 10.1128/aac.00017-09
Escherichia coli Metallo-beta-lactamase Kcat/Km 0.69 /s/microM 10.1128/aac.00017-09
Fluoribacter gormanii FEZ-1 protein Kcat/Km 1.3 10'4/M/s 10.1128/aac.01062-07
Homo sapiens Acetylcholinesterase AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Adenosine A1 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Adenosine A3 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-1a adrenergic receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-2a adrenergic receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Androgen Receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Bile salt export pump AC50 300000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Cyclooxygenase-1 AC50 15608.8 nM 10.1038/s41467-023-40064-9
Homo sapiens Cyclooxygenase-1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine D1 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine D3 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine transporter AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Estrogen receptor alpha AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens HERG AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Histamine H3 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Homo sapiens CL 2.2 mL.min-1.kg-1 10.1021/jm900403j
Homo sapiens Homo sapiens CL_renal 1.9 mL.min-1.kg-1 10.1021/jm900403j
Homo sapiens Monoamine oxidase A AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Mu opioid receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Muscarinic acetylcholine receptor M1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Muscarinic acetylcholine receptor M2 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Norepinephrine transporter AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens P-glycoprotein 1 Alpha max 0.0 None 10.1021/jm101421d
Homo sapiens P-glycoprotein 1 Inhibition nan % 10.1021/jm101421d
Homo sapiens Phosphodiesterase 3A AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Phosphodiesterase 4A AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Progesterone receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 1a (5-HT1a) receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2b (5-HT2b) receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin transporter AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Solute carrier family 22 member 8 Inhibition nan % 10.1124/dmd.112.049569
Homo sapiens Thrombin AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Thromboxane A2 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Vascular endothelial growth factor receptor 2 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Klebsiella pneumoniae Beta-lactamase SHV-1 Kcat 220.0 /s 10.1128/aac.01381-07
Klebsiella pneumoniae Beta-lactamase SHV-1 Kcat 220.0 /s 10.1128/aac.01525-07
Klebsiella pneumoniae Beta-lactamase SHV-1 Kcat/Km 20.0 /uM/s 10.1128/aac.01381-07
Klebsiella pneumoniae Beta-lactamase SHV-1 Kcat/Km 20.4 /uM/s 10.1128/aac.01525-07
Klebsiella pneumoniae Beta-lactamase SHV-1 Km 11000.0 nM 10.1128/aac.01381-07
Klebsiella pneumoniae Beta-lactamase SHV-1 Km 11000.0 nM 10.1128/aac.01525-07
Klebsiella pneumoniae Beta-lactamase SHV-55 Kcat 8.0 /s 10.1128/aac.01525-07
Klebsiella pneumoniae Beta-lactamase SHV-55 Kcat/Km 1.5 /uM/s 10.1128/aac.01525-07
Klebsiella pneumoniae Beta-lactamase SHV-55 Km 6000.0 nM 10.1128/aac.01525-07
Klebsiella pneumoniae Beta-lactamase SHV-72 Kcat 1279.0 /s 10.1128/aac.01381-07
Klebsiella pneumoniae Beta-lactamase SHV-72 Kcat/Km 35.5 /uM/s 10.1128/aac.01381-07
Klebsiella pneumoniae Beta-lactamase SHV-72 Km 36000.0 nM 10.1128/aac.01381-07
Klebsiella pneumoniae Klebsiella pneumoniae MIC 8.0 ug.mL-1 10.1128/aac.00690-09
Klebsiella pneumoniae Klebsiella pneumoniae MIC 256.0 ug.mL-1 10.1128/aac.00543-08
Klebsiella pneumoniae Klebsiella pneumoniae MIC 256.0 ug.mL-1 10.1128/aac.00690-09
Klebsiella pneumoniae Klebsiella pneumoniae MIC 256.0 ug.mL-1 10.1128/aac.01180-07
Klebsiella pneumoniae Klebsiella pneumoniae MIC 256.0 ug.mL-1 10.1128/aac.01284-08
Klebsiella pneumoniae Klebsiella pneumoniae MIC 256.0 ug.mL-1 10.1128/aac.01312-09
Klebsiella pneumoniae Klebsiella pneumoniae MIC 256.0 ug.mL-1 10.1128/aac.01451-07
Klebsiella pneumoniae Klebsiella pneumoniae MIC 512.0 ug.mL-1 10.1128/aac.00458-09
Klebsiella pneumoniae Klebsiella pneumoniae MIC 512.0 ug.mL-1 10.1128/aac.01312-09
Klebsiella pneumoniae Klebsiella pneumoniae MIC 512.0 ug.mL-1 10.1128/aac.01381-07
Klebsiella pneumoniae Klebsiella pneumoniae MIC 512.0 ug.mL-1 10.1128/aac.01672-07
Klebsiella pneumoniae Klebsiella pneumoniae MIC 1024.0 ug.mL-1 10.1128/aac.00387-08
Klebsiella pneumoniae Klebsiella pneumoniae MIC 2048.0 ug.mL-1 10.1128/aac.00017-09
Klebsiella pneumoniae Klebsiella pneumoniae MIC 4096.0 ug.mL-1 10.1128/aac.00387-08
Mus musculus Monoamine oxidase A Activity nan None 10.1021/jm800656v
Mus musculus Monoamine oxidase B Activity nan None 10.1021/jm800656v
Mus musculus Solute carrier family 22 member 20 Ki 533000.0 nM 10.1074/jbc.m703467200
Mus musculus Solute carrier family 22 member 20 Ki 537031.8 nM 10.1074/jbc.m703467200
Mus musculus Solute carrier family 22 member 6 Inhibition nan % 10.1124/dmd.112.049569
Mus musculus Solute carrier family 22 member 6 Ki 524807.46 nM 10.1074/jbc.m703467200
Mus musculus Solute carrier family 22 member 6 Ki 530000.0 nM 10.1074/jbc.m703467200
Mus musculus Solute carrier family 22 member 8 Drug uptake nan None 10.1124/dmd.112.049569
Mus musculus Solute carrier family 22 member 8 IC50 233000.0 nM 10.1124/dmd.112.049569
Mus musculus Solute carrier family 22 member 8 Inhibition nan % 10.1124/dmd.112.049569
Pectobacterium atrosepticum Pectobacterium atrosepticum MIC 4.0 ug.mL-1 10.1128/aac.01062-07
Proteus mirabilis Proteus mirabilis MIC 32.0 ug.mL-1 10.1128/aac.01399-07
Providencia rettgeri Providencia rettgeri MIC 256.0 ug.mL-1 10.1128/aac.01312-09
Providencia stuartii Providencia stuartii MIC 2048.0 ug.mL-1 10.1128/aac.00017-09
Pseudomonas aeruginosa Pseudomonas aeruginosa Activity 10.8 % 10.1128/aac.00503-07
Pseudomonas aeruginosa Pseudomonas aeruginosa Activity 11.0 % 10.1128/aac.00810-07
Pseudomonas aeruginosa Pseudomonas aeruginosa Activity 28.5 % 10.1128/aac.01483-06
Pseudomonas aeruginosa Pseudomonas aeruginosa Activity 34.0 % 10.1128/aac.00810-07
Pseudomonas aeruginosa Pseudomonas aeruginosa Activity 77.5 % 10.1128/aac.00503-07
Pseudomonas aeruginosa Pseudomonas aeruginosa FC 64.0 None 10.1128/aac.01024-08
Pseudomonas aeruginosa Pseudomonas aeruginosa FICI nan None 10.1128/aac.01071-07
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 0.25 ug.mL-1 10.1128/aac.01451-07
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 0.38 ug.mL-1 10.1128/aac.01451-07
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 0.5 ug.mL-1 10.1128/aac.01024-08
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 1.0 ug.mL-1 10.1128/aac.01024-08
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 2.0 ug.mL-1 10.1128/aac.01024-08
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 2.0 ug.mL-1 10.1128/aac.01107-07
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 4.0 ug.mL-1 10.1128/aac.00503-07
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 4.0 ug.mL-1 10.1128/aac.01107-07
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 8.0 ug.mL-1 10.1016/j.bmc.2015.08.031
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 8.0 ug.mL-1 10.1128/aac.00893-09
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 8.0 ug.mL-1 10.1128/aac.01107-07
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 12.0 ug.mL-1 10.1128/aac.00810-07
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 16.0 ug.mL-1 10.1128/aac.00110-10
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 16.0 ug.mL-1 10.1128/aac.00503-07
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 16.0 ug.mL-1 10.1128/aac.01024-08
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 16.0 ug.mL-1 10.1128/aac.01107-07
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 20.0 ug.mL-1 10.1128/aac.01071-07
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 32.0 ug.mL-1 10.1128/aac.00110-10
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 32.0 ug.mL-1 10.1128/aac.00503-07
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 32.0 ug.mL-1 10.1128/aac.00893-09
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 32.0 ug.mL-1 10.1128/aac.01024-08
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 64.0 ug.mL-1 10.1128/aac.00110-10
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 64.0 ug.mL-1 10.1128/aac.00503-07
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 64.0 ug.mL-1 10.1128/aac.01483-06
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 128.0 ug.mL-1 10.1128/aac.00503-07
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 128.0 ug.mL-1 10.1128/aac.01646-09
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 256.0 ug.mL-1 10.1128/aac.00503-07
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 256.0 ug.mL-1 10.1128/aac.00810-07
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 256.0 ug.mL-1 10.1128/aac.01451-07
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 256.0 ug.mL-1 10.1128/aac.01573-08
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 256.0 ug.mL-1 10.1128/aac.01646-09
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 512.0 ug.mL-1 10.1128/aac.00110-10
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 512.0 ug.mL-1 10.1128/aac.00859-09
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 512.0 ug.mL-1 10.1128/aac.01561-09
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 512.0 ug.mL-1 10.1128/aac.01646-09
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 1120.0 ug.mL-1 10.1128/aac.01071-07
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC nan None 10.1128/aac.01024-08
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC nan None 10.1128/aac.01107-07
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC50 32.0 ug.mL-1 10.1128/aac.00503-07
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC50 128.0 ug.mL-1 10.1021/acs.jmedchem.7b00377
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC90 128.0 ug.mL-1 10.1021/acs.jmedchem.7b00377
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC90 256.0 ug.mL-1 10.1128/aac.00503-07
Pseudomonas fluorescens Beta-lactamase Kcat/Km 60.0 /mM/s 10.1128/aac.00961-09
Pseudomonas fluorescens Pseudomonas fluorescens MIC 256.0 ug.mL-1 10.1128/aac.00961-09
Pseudomonas luteola Beta-lactamase Kcat 5.0 /s 10.1128/aac.00427-09
Pseudomonas luteola Beta-lactamase Kcat/Km 0.36 /s/microM 10.1128/aac.00427-09
Pseudomonas luteola Beta-lactamase Km 14000.0 nM 10.1128/aac.00427-09
Pseudomonas putida Pseudomonas putida MIC 128.0 ug.mL-1 10.1128/aac.00838-06
Pseudomonas stutzeri Metallo-beta-lactamase Kcat 250.0 /s 10.1128/aac.01456-09
Pseudomonas stutzeri Metallo-beta-lactamase Km 80000.0 nM 10.1128/aac.01456-09
Pseudomonas stutzeri Metallo-beta-lactamase Ratio 15000.0 None 10.1128/aac.01456-09
Rattus norvegicus GABA receptor alpha-1 subunit AC50 30000.0 nM 10.1038/s41467-023-40064-9
Salmonella enterica subsp. enterica serovar Typhimurium Salmonella typhimurium MIC 4.0 ug.mL-1 10.1128/aac.01472-06
Salmonella enterica subsp. enterica serovar Westhampton Extended-spectrum beta-lactamase CTX-M-53 Kcat 10.0 /s 10.1128/aac.01581-08
Salmonella enterica subsp. enterica serovar Westhampton Extended-spectrum beta-lactamase CTX-M-53 Kcat/Km 0.5 /s/microM 10.1128/aac.01581-08
Salmonella enterica subsp. enterica serovar Westhampton Extended-spectrum beta-lactamase CTX-M-53 Km 18000.0 nM 10.1128/aac.01581-08
Shouchella clausii Shouchella clausii MIC 8000.0 ug.mL-1 10.1128/aac.00537-07
Staphylococcus aureus Staphylococcus aureus MIC 1.0 ug.mL-1 10.1128/aac.01472-06
Staphylococcus aureus Staphylococcus aureus MIC 32.0 ug.mL-1 10.1128/aac.01472-06
Staphylococcus aureus Staphylococcus aureus MIC 512.0 ug.mL-1 10.1128/aac.01472-06
Stenotrophomonas maltophilia Beta-lactamase L1 Kcat/Km 2.7 10'6/M/s 10.1128/aac.01062-07
Stutzerimonas stutzeri Stutzerimonas stutzeri MIC 512.0 ug.mL-1 10.1128/aac.01456-09
None ADMET CL 1.8 mL.min-1.kg-1 10.1124/dmd.108.020479
None ADMET log10(%HIA +10) 1.176 None 10.1016/j.ejmech.2010.11.005
None ADMET MRT 1.5 hr 10.1124/dmd.108.020479
None ADMET T1/2 1.0 hr 10.1124/dmd.108.020479
None ADMET Vdss 0.16 L.kg-1 10.1124/dmd.108.020479
None NON-PROTEIN TARGET Fu 0.55 None 10.1124/dmd.108.020479
None NON-PROTEIN TARGET Hepatotoxicity (acute) 0.0 % 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (animal toxicity known) nan None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (benign tumour) 0.0 None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (granulomatous hepatitis) 0.0 None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (mechanism) nan None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (moderate) 5.0 % 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (moderate) 7.0 None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (time to onset) nan None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET MIC 0.125 ug.mL-1 10.1128/aac.01252-09
None NON-PROTEIN TARGET MIC 0.25 ug.mL-1 10.1128/aac.00791-09
None NON-PROTEIN TARGET MIC 1.0 ug.mL-1 10.1128/aac.01463-07
None NON-PROTEIN TARGET MIC 2.0 ug.mL-1 10.1128/aac.00427-09
None NON-PROTEIN TARGET MIC 4.0 ug.mL-1 10.1128/aac.00427-09
None NON-PROTEIN TARGET MIC 4.0 ug.mL-1 10.1128/aac.00791-09
None NON-PROTEIN TARGET MIC 4.0 ug.mL-1 10.1128/aac.00978-07
None NON-PROTEIN TARGET MIC 4.0 ug.mL-1 10.1128/aac.01463-07
None NON-PROTEIN TARGET MIC 8.0 ug.mL-1 10.1128/aac.00427-09
None NON-PROTEIN TARGET MIC 8.0 ug.mL-1 10.1128/aac.01252-09
None NON-PROTEIN TARGET MIC 16.0 ug.mL-1 10.1128/aac.00128-10
None NON-PROTEIN TARGET MIC 64.0 ug.mL-1 10.1128/aac.01152-06
None NON-PROTEIN TARGET MIC 64.0 ug.mL-1 10.1128/aac.01463-07
None NON-PROTEIN TARGET MIC 128.0 ug.mL-1 10.1128/aac.01581-08
None NON-PROTEIN TARGET MIC 256.0 ug.mL-1 10.1128/aac.00128-10
None NON-PROTEIN TARGET MIC 256.0 ug.mL-1 10.1128/aac.01284-08
None NON-PROTEIN TARGET MIC 256.0 ug.mL-1 10.1128/aac.01581-08
None NON-PROTEIN TARGET MIC 256.0 ug.mL-1 10.1128/aac.01585-09
None NON-PROTEIN TARGET MIC 512.0 ug.mL-1 10.1128/aac.00978-07
None NON-PROTEIN TARGET MIC 512.0 ug.mL-1 10.1128/aac.01600-06
None NON-PROTEIN TARGET MIC 1024.0 ug.mL-1 10.1128/aac.00128-10
None Unchecked Activity 94.0 % 10.1128/aac.01164-08
None Unchecked Activity 100.0 % 10.1128/aac.01164-08
None Unchecked FC 10.0 None 10.1128/aac.00537-07
None Unchecked Hepatotoxicity (acute) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (association with vascular disease) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (choleostasis) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (chronic liver disease) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (cirrhosis) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (comment) nan None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (cytolytic) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (malignant tumour) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (severe hepatitis) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (steatosis) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (successful reintroduction) nan None 10.1016/s0399-8320(04)95062-2
None Unchecked Kcat 0.1 /s 10.1128/aac.01463-07
None Unchecked Kcat 1.0 /s 10.1128/aac.00856-09
None Unchecked Kcat 1.1 /s 10.1128/aac.00858-10
None Unchecked Kcat 9.0 /s 10.1128/aac.01062-07
None Unchecked Kcat 15.0 /s 10.1128/aac.00961-09
None Unchecked Kcat 15.0 /s 10.1128/aac.01164-08
None Unchecked Kcat 19.0 /s 10.1128/aac.00614-07
None Unchecked Kcat 30.0 /s 10.1128/aac.00387-08
None Unchecked Kcat 30.0 /s 10.1128/aac.00858-10
None Unchecked Kcat 35.0 /s 10.1128/aac.01145-07
None Unchecked Kcat 35.0 /s 10.1128/aac.01600-06
None Unchecked Kcat 38.0 /s 10.1128/aac.01058-06
None Unchecked Kcat 42.0 /s 10.1128/aac.01058-06
None Unchecked Kcat 45.8 /s 10.1128/aac.00017-09
None Unchecked Kcat 51.0 /s 10.1128/aac.01058-06
None Unchecked Kcat 60.0 /s 10.1128/aac.01058-06
None Unchecked Kcat 125.0 /s 10.1128/aac.00614-07
None Unchecked Kcat 135.0 /s 10.1128/aac.01058-06
None Unchecked Kcat 176.0 /s 10.1128/aac.01058-06
None Unchecked Kcat 216.0 /s 10.1128/aac.01442-09
None Unchecked Kcat 252.0 /s 10.1128/aac.01462-06
None Unchecked Kcat nan None 10.1128/aac.00163-08
None Unchecked Kcat/Km 0.003 /s/microM 10.1128/aac.00856-09
None Unchecked Kcat/Km 0.36 None 10.1128/aac.01462-06
None Unchecked Kcat/Km 0.4 None 10.1128/aac.00614-07
None Unchecked Kcat/Km 0.7 /s/microM 10.1128/aac.00017-09
None Unchecked Kcat/Km 1.3 10'4/M/s 10.1128/aac.00409-10
None Unchecked Kcat/Km 1.3 10'4/M/s 10.1128/aac.01062-07
None Unchecked Kcat/Km 1.3 /uM/s 10.1128/aac.01058-06
None Unchecked Kcat/Km 1.4 /uM/s 10.1128/aac.01058-06
None Unchecked Kcat/Km 1.5 10'3/M/s 10.1128/aac.00858-10
None Unchecked Kcat/Km 1.5 10'5/M/s 10.1128/aac.00858-10
None Unchecked Kcat/Km 1.5 /uM/s 10.1128/aac.01164-08
None Unchecked Kcat/Km 1.6 None 10.1128/aac.00614-07
None Unchecked Kcat/Km 2.5 /uM/s 10.1128/aac.01442-09
None Unchecked Kcat/Km 2.7 10'6/M/s 10.1128/aac.00409-10
None Unchecked Kcat/Km 2.9 /uM/s 10.1128/aac.01058-06
None Unchecked Kcat/Km 3.0 /uM/s 10.1128/aac.01058-06
None Unchecked Kcat/Km 3.8 /uM/s 10.1128/aac.01058-06
None Unchecked Kcat/Km 4.2 /uM/s 10.1128/aac.01058-06
None Unchecked Kcat/Km 5.0 None 10.1128/aac.01145-07
None Unchecked Kcat/Km 5.2 10'5/M/s 10.1128/aac.00409-10
None Unchecked Kcat/Km 70.0 /uM/s 10.1128/aac.00387-08
None Unchecked Kcat/Km 330.0 /mM/s 10.1128/aac.01145-07
None Unchecked Kcat/Km 750.0 /mM/s 10.1128/aac.01082-06
None Unchecked Kcat/Km nan None 10.1128/aac.00163-08
None Unchecked Kcat/Km nan None 10.1128/aac.00961-09
None Unchecked Kcat/Km nan None 10.1128/aac.01062-07
None Unchecked Kcat/Km nan None 10.1128/aac.01585-09
None Unchecked Km 12.0 /s/microM 10.1128/aac.00614-07
None Unchecked Km 320.0 /s/microM 10.1128/aac.00614-07
None Unchecked Km 9000.0 nM 10.1128/aac.01058-06
None Unchecked Km 10000.0 nM 10.1128/aac.01164-08
None Unchecked Km 14000.0 nM 10.1128/aac.01058-06
None Unchecked Km 21000.0 nM 10.1128/aac.01058-06
None Unchecked Km 36000.0 nM 10.1128/aac.01058-06
None Unchecked Km 40000.0 nM 10.1128/aac.01082-06
None Unchecked Km 40000.0 nM 10.1128/aac.01463-07
None Unchecked Km 80000.0 nM 10.1128/aac.01600-06
None Unchecked Km 83000.0 nM 10.1128/aac.01442-09
None Unchecked Km 106000.0 nM 10.1128/aac.01145-07
None Unchecked Km 130000.0 nM 10.1128/aac.01058-06
None Unchecked Km 140000.0 nM 10.1128/aac.00409-10
None Unchecked Km 150000.0 nM 10.1128/aac.00409-10
None Unchecked Km 180000.0 nM 10.1128/aac.00858-10
None Unchecked Km 250000.0 nM 10.1128/aac.00961-09
None Unchecked Km 370000.0 nM 10.1128/aac.00856-09
None Unchecked Km 450000.0 nM 10.1128/aac.00387-08
None Unchecked Km 640000.0 nM 10.1128/aac.01062-07
None Unchecked Km 700000.0 nM 10.1128/aac.01462-06
None Unchecked Km 740000.0 nM 10.1128/aac.00858-10
None Unchecked Km 5000000.0 nM 10.1128/aac.00409-10
None Unchecked Km nan None 10.1128/aac.00163-08
None Unchecked Km nan None 10.1128/aac.00409-10
None Unchecked Ratio 2.5 None 10.1128/aac.01463-07
None Unchecked Ratio 8.0 None 10.1128/aac.00614-07
None Unchecked Ratio 450.0 /mM/s 10.1128/aac.01600-06
None Unchecked Ratio pKi 0.0 None 10.1074/jbc.m703467200

Metabolism Information