Molecule

Lactimidomycin

AlkaPlorer ID: AK020157

Synonym: 'Lactimidomycin', 'Bu 4146T'

IUPAC Name: 4-[(E,2R,5S)-2-hydroxy-5-methyl-7-[(2R,3S,4Z,6E,10E)-3-methyl-12-oxo-1-oxacyclododeca-4,6,10-trien-2-yl]-4-oxooct-6-enyl]piperidine-2,6-dione

Structure

SMILES: C/C(=C\[C@H](C)C(=O)C[C@H](O)CC1CC(=O)N=C(O)C1)[C@@H]1OC(=O)/C=C/CC/C=C/C=C\[C@@H]1C

InChI: InChI=1S/C26H35NO6/c1-17-10-8-6-4-5-7-9-11-25(32)33-26(17)19(3)12-18(2)22(29)16-21(28)13-20-14-23(30)27-24(31)15-20/h4,6,8-12,17-18,20-21,26,28H,5,7,13-16H2,1-3H3,(H,27,30,31)/b6-4+,10-8-,11-9+,19-12+/t17-,18-,21+,26+/m0/s1

InChIKey: OYOKHBHOTQDIPM-BRHOHSSQSA-N

Reference

New Lactimidomycin Congeners Shed Insight into Lactimidomycin Biosynthesis in <i>Streptomyces </i><i>amphibiosporus</i>

PubChem CID: 11669726

LOTUS: LTS0183368

SuperNatural Ⅲ: SN0278585-13

Source

Species	Genus	Family	Order	Class	Phylum	Kingdom	Domain
Streptomyces amphibiosporus	Streptomyces	Streptomycetaceae	Kitasatosporales	Actinomycetes	Actinomycetota	None	Bacteria

Properties Information

Molecule Weight: 457.5670000000002

TPSA？: 113.26

MolLogP？: 4.182400000000003

Number of H-Donors: 2

Number of H-Acceptors: 5

RingCount: 2

Activities Information

Organism	Target Name	Standard Type	Standard Value	Standard Units	doi
dengue virus type 2	dengue virus type 2	EC50	400.0	nM	10.1016/j.ejmech.2019.05.010
Homo sapiens	BT-474	Activity	nan	None	10.1038/nchembio.304
Homo sapiens	Elongation factor 1-alpha 1	Activity	nan	None	10.1038/nchembio.304
Homo sapiens	Elongation factor 1-alpha 1	Inhibition	nan	%	10.1038/nchembio.304
Homo sapiens	Elongation factor 2	Inhibition	nan	%	10.1038/nchembio.304
Homo sapiens	HCC1395	Activity	nan	None	10.1038/nchembio.304
Homo sapiens	HCC1937	Activity	nan	None	10.1038/nchembio.304
Homo sapiens	HCC2218	Activity	nan	None	10.1038/nchembio.304
Homo sapiens	HEK-293T	Activity	nan	None	10.1038/nchembio.304
Homo sapiens	HeLa	Activity	nan	None	10.1038/nchembio.304
Homo sapiens	HeLa	IC50	37.82	nM	10.1038/nchembio.304
Homo sapiens	HeLa	IC50	10000.0	nM	10.1038/nchembio.304
Homo sapiens	HeLa	Inhibition	nan	%	10.1038/nchembio.304
Homo sapiens	Jurkat	Activity	nan	None	10.1038/nchembio.304
Homo sapiens	MCF-10A	Activity	nan	None	10.1038/nchembio.304
Homo sapiens	MCF7	Activity	nan	None	10.1038/nchembio.304
Homo sapiens	MDA-MB-231	Activity	nan	None	10.1038/nchembio.304
Saccharomyces cerevisiae	Saccharomyces cerevisiae	IC50	4.6	nM	10.1038/nchembio.304
Saccharomyces cerevisiae	Saccharomyces cerevisiae	IC50	58.0	nM	10.1038/nchembio.304
Saccharomyces cerevisiae	Saccharomyces cerevisiae	IC50	59.0	nM	10.1038/nchembio.304
Saccharomyces cerevisiae	Saccharomyces cerevisiae	IC50	488.0	nM	10.1038/nchembio.304
Saccharomyces cerevisiae	Saccharomyces cerevisiae	IC50	596.0	nM	10.1038/nchembio.304
Saccharomyces cerevisiae	Saccharomyces cerevisiae	IC50	1108.0	nM	10.1038/nchembio.304
Saccharomyces cerevisiae	Saccharomyces cerevisiae	IC50	1209.0	nM	10.1038/nchembio.304
Saccharomyces cerevisiae	Saccharomyces cerevisiae	IC50	6533.0	nM	10.1038/nchembio.304
Saccharomyces cerevisiae	Saccharomyces cerevisiae	Ratio IC50	10.3	None	10.1038/nchembio.304
Saccharomyces cerevisiae	Saccharomyces cerevisiae	Ratio IC50	13.4	None	10.1038/nchembio.304
Saccharomyces cerevisiae	Saccharomyces cerevisiae	Ratio IC50	20.5	None	10.1038/nchembio.304
Saccharomyces cerevisiae	Saccharomyces cerevisiae	Ratio IC50	241.0	None	10.1038/nchembio.304
None	NON-PROTEIN TARGET	Activity	nan	None	10.1038/nchembio.304
None	Unchecked	Activity	nan	None	10.1038/nchembio.304
None	Unchecked	Inhibition	nan	%	10.1038/nchembio.304
None	Unchecked	Kd	500.0	nM	10.1038/nchembio.304