UNPD181512
AlkaPlorer ID: AK020636
Synonym: None
IUPAC Name: (4R,5S,6Z,10S)-4,10-dihydroxy-2-methoxy-3-methylidene-6-propylidene-2-azaspiro[4.5]dec-7-ene-1,9-dione
Structure
SMILES: C=C1[C@H](O)[C@@]2(C(=O)N1OC)/C(=C\CC)C=CC(=O)[C@H]2O
InChI: InChI=1S/C14H17NO5/c1-4-5-9-6-7-10(16)12(18)14(9)11(17)8(2)15(20-3)13(14)19/h5-7,11-12,17-18H,2,4H2,1,3H3/b9-5-/t11-,12+,14-/m0/s1
InChIKey: UEEZHRJFRYRGNC-VXJKQWIASA-N
Reference
Spirostaphylotrichins U and V from Curvularia pallescens
PubChem CID: 10333817
LOTUS: LTS0057373
SuperNatural Ⅲ: SN0368050-06
NPASS: NPC126719
Source
| Species | Genus | Family | Order | Class | Phylum | Kingdom | Domain |
|---|
Properties Information
Molecule Weight: 279.292
TPSA？: 87.07000000000001
MolLogP？: 0.0872
Number of H-Donors: 2
Number of H-Acceptors: 5
RingCount: 2
Activities Information
| Organism | Target Name | Standard Type | Standard Value | Standard Units | doi |
|---|---|---|---|---|---|
| Arabidopsis thaliana | Arabidopsis thaliana | Inhibition | nan | % | 10.1021/acs.jnatprod.8b00656 |
| Cynodon dactylon | Cynodon dactylon | Inhibition | nan | % | 10.1021/acs.jnatprod.8b00656 |
| Erysipelothrix rhusiopathiae | Erysipelothrix rhusiopathiae | MIC | 100.0 | ug.mL-1 | 10.1021/acs.jnatprod.8b00656 |
| Escherichia coli | Escherichia coli | MIC | 100.0 | ug.mL-1 | 10.1021/acs.jnatprod.8b00656 |
| Homo sapiens | 786-0 | IC50 | 50000.0 | nM | 10.1021/acs.jnatprod.8b00656 |
| Homo sapiens | ACHN | IC50 | 50000.0 | nM | 10.1021/acs.jnatprod.8b00656 |
| Homo sapiens | HepG2 | IC50 | 50000.0 | nM | 10.1021/acs.jnatprod.8b00656 |
| Homo sapiens | OS-RC-2 | IC50 | 50000.0 | nM | 10.1021/acs.jnatprod.8b00656 |
| Homo sapiens | SGC-7901 | IC50 | 50000.0 | nM | 10.1021/acs.jnatprod.8b00656 |
| Influenza A virus | Influenza A virus | IC50 | 21000.0 | nM | 10.1021/acs.jnatprod.8b00656 |
| Staphylococcus aureus | Staphylococcus aureus | MIC | 100.0 | ug.mL-1 | 10.1021/acs.jnatprod.8b00656 |
| None | Unchecked | MIC | 100.0 | ug.mL-1 | 10.1021/acs.jnatprod.8b00656 |