Oxypalmatine
AlkaPlorer ID: AK020658
Synonym: ''
IUPAC Name: 2,3,9,10-tetramethoxy-5,6-dihydroisoquinolino[2,1-b]isoquinolin-8-one
Structure
SMILES: COC1=C(OC)C=C2C(=C1)CCN1C2=CC2=CC=C(OC)C(OC)=C2C1=O
InChI: InChI=1S/C21H21NO5/c1-24-16-6-5-13-9-15-14-11-18(26-3)17(25-2)10-12(14)7-8-22(15)21(23)19(13)20(16)27-4/h5-6,9-11H,7-8H2,1-4H3
InChIKey: MZIUUCTTWZPXOV-UHFFFAOYSA-N
Reference
The isoindolobenzazepine alkaloids
PubChem CID: 10926678
CAS: 19716-59-7
LOTUS: LTS0238575
SuperNatural Ⅲ: SN0239397
COCONUT: CNP0204644
data_source: manually
Source
| Species | Genus | Family | Order | Class | Phylum | Kingdom | Domain |
|---|---|---|---|---|---|---|---|
| Coscinium fenestratum | Coscinium | Menispermaceae | Ranunculales | Magnoliopsida | Streptophyta | Viridiplantae | Eukaryota |
Properties Information
Molecule Weight: 367.4010000000001
TPSA？: 58.92000000000001
MolLogP？: 3.259000000000002
Number of H-Donors: 0
Number of H-Acceptors: 6
RingCount: 4
Activities Information
| Organism | Target Name | Standard Type | Standard Value | Standard Units | doi |
|---|---|---|---|---|---|
| Candida albicans | Candida albicans | MIC | 250.0 | ug.mL-1 | 10.1016/j.bmc.2018.04.025 |
| Escherichia coli | Escherichia coli | MIC | 250.0 | ug.mL-1 | 10.1016/j.bmc.2018.04.025 |
| Homo sapiens | HEK293 | Activity | nan | None | 10.1021/acs.jnatprod.6b00409 |
| Rattus norvegicus | IEC-6 | Survival | 70.0 | % | 10.1016/j.bmc.2018.04.025 |
| Staphylococcus aureus | Staphylococcus aureus | MIC | 250.0 | ug.mL-1 | 10.1016/j.bmc.2018.04.025 |
| None | Molecular identity unknown | IC50 | 600.0 | nM | 10.1021/acs.jnatprod.6b00409 |
| None | NON-PROTEIN TARGET | Activity | nan | None | 10.1021/acs.jnatprod.6b00409 |