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name Structure Reference Source Properties Activities Metabolism

1-Piperoylpiperidine; (2E,4E)-form, 2,3,4,5-Tetrahydro 

AlkaPlorer ID: AK020682

Synonym: 1-[5-(3,4-Methylenedioxyphenyl)pentanoyl]piperidine, Tetrahydropiperine

IUPAC Name: 5-(1,3-benzodioxol-5-yl)-1-piperidin-1-ylpentan-1-one

Structure

SMILES: O=C(CCCCC1=CC=C2OCOC2=C1)N1CCCCC1

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InChI: InChI=1S/C17H23NO3/c19-17(18-10-4-1-5-11-18)7-3-2-6-14-8-9-15-16(12-14)21-13-20-15/h8-9,12H,1-7,10-11,13H2

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InChIKey: APZYKUZPJCQGPP-UHFFFAOYSA-N

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Source

Species Genus Family Order Class Phylum Kingdom Domain
Piper longum Piper Piperaceae Piperales Magnoliopsida Streptophyta Viridiplantae Eukaryota

Properties Information

Molecule Weight: 289.37500000000006

TPSA？: 38.77

MolLogP？: 3.140600000000002

Number of H-Donors: 0

Number of H-Acceptors: 3

RingCount: 3

Activities Information

Organism Target Name Standard Type Standard Value Standard Units doi
Homo sapiens Vanilloid receptor Activity nan None 10.1016/j.bmc.2010.03.013
Homo sapiens Vanilloid receptor EC50 6309.57 nM 10.1016/j.bmc.2010.03.013
Homo sapiens Vanilloid receptor Emax 90.0 % 10.1016/j.bmc.2010.03.013
Rattus norvegicus Monoamine oxidase A IC50 100000.0 nM 10.1016/j.bmcl.2012.02.090
Rattus norvegicus Monoamine oxidase B IC50 1970.0 nM 10.1016/j.bmcl.2012.02.090
Staphylococcus aureus Quinolone resistance protein norA FC 0.0 None 10.1016/j.bmc.2008.09.042
Staphylococcus aureus Quinolone resistance protein norA FC 2.0 None 10.1016/j.bmc.2008.09.042
Staphylococcus aureus Quinolone resistance protein norA FC 2.0 None 10.1016/j.ejmech.2009.05.004
Staphylococcus aureus Quinolone resistance protein norA logPF 1.3 None 10.1016/j.ejmech.2009.05.004
Staphylococcus aureus Quinolone resistance protein norA MEC 50.0 ug ml-1 10.1016/j.ejmech.2009.05.004
Staphylococcus aureus Quinolone resistance protein norA MIC 100.0 ug.mL-1 10.1016/j.ejmech.2009.05.004
Staphylococcus aureus Quinolone resistance protein norA PF 20.0 None 10.1016/j.ejmech.2009.05.004
Trypanosoma cruzi Trypanosoma cruzi IC50 11520.0 nM 10.1016/j.bmcl.2004.04.019
Trypanosoma cruzi Trypanosoma cruzi IC50 19000.0 nM 10.1016/j.bmc.2010.01.068
Trypanosoma cruzi Trypanosoma cruzi IC50 19410.0 nM 10.1016/j.bmcl.2004.04.019
Trypanosoma cruzi Trypanosoma cruzi IC50 nan None 10.1007/s00044-008-9161-9

Metabolism Information