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name Structure Reference Source Properties Activities Metabolism

1,2,3,4-Tetrahydro-6,7-dihydroxyisoquinoline; 6-Me ether, N-Me 

AlkaPlorer ID: AK020779

Synonym: 1,2,3,4-Tetrahydro-6-methoxy-2-methyl-7-isoquinolinol, 1,2,3,4-Tetrahydro-7-hydroxy-6-methoxy-2-methylisoquinoline, Corypalline

IUPAC Name: 6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-2-ium-7-ol

Structure

SMILES: COC1=C(O)C=C2C[NH+](C)CCC2=C1

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InChI: InChI=1S/C11H15NO2/c1-12-4-3-8-6-11(14-2)10(13)5-9(8)7-12/h5-6,13H,3-4,7H2,1-2H3/p+1

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InChIKey: FELOSQQXIHRUSH-UHFFFAOYSA-O

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Source

Species Genus Family Order Class Phylum Kingdom Domain
Ulex airensis Ulex Fabaceae Fabales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Stachys plumosa Stachys Lamiaceae Lamiales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Koenigia coriaria Koenigia Polygonaceae Caryophyllales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Piper methysticum Piper Piperaceae Piperales Magnoliopsida Streptophyta Viridiplantae Eukaryota
None Thalictrum Ranunculaceae Ranunculales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Artabotrys maingayi Artabotrys Annonaceae Magnoliales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Diospyros ebenum Diospyros Ebenaceae Ericales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Doryphora sassafras Doryphora Atherospermataceae Laurales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Cryptostegia madagascariensis Cryptostegia Apocynaceae Gentianales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Ligularia sagitta Ligularia Asteraceae Asterales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Angelica dahurica Angelica Apiaceae Apiales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Lappula echinata Lappula Boraginaceae Boraginales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Corydalis ophiocarpa Corydalis Papaveraceae Ranunculales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Thuja plicata Thuja Cupressaceae Cupressales Pinopsida Streptophyta Viridiplantae Eukaryota
Papaver bracteatum Papaver Papaveraceae Ranunculales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Thalictrum dasycarpum Thalictrum Ranunculaceae Ranunculales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Corydalis ternata Corydalis Papaveraceae Ranunculales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Stereocaulon alpinum Stereocaulon Stereocaulaceae Lecanorales Lecanoromycetes Ascomycota Fungi Eukaryota
Labidiaster annulatus Labidiaster Labidiasteridae Forcipulatida Asteroidea Echinodermata Metazoa Eukaryota
Copris tripartitus Copris Scarabaeidae Coleoptera Insecta Arthropoda Metazoa Eukaryota
Senna spectabilis Senna Fabaceae Fabales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Chaetomorpha moniligera Chaetomorpha Cladophoraceae Cladophorales Ulvophyceae Chlorophyta Viridiplantae Eukaryota
Lasius niger Lasius Formicidae Hymenoptera Insecta Arthropoda Metazoa Eukaryota
Coleonema pulchellum Coleonema Rutaceae Sapindales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Tamarix chinensis Tamarix Tamaricaceae Caryophyllales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Corydalis pallida Corydalis Papaveraceae Ranunculales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Streptomyces aizunensis Streptomyces Streptomycetaceae Kitasatosporales Actinomycetes Actinomycetota None Bacteria
Symphytum officinale Symphytum Boraginaceae Boraginales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Dictyostelium longosporum Dictyostelium Dictyosteliaceae Dictyosteliales Eumycetozoa Evosea None Eukaryota
Corydalis aurea Corydalis Papaveraceae Ranunculales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Psacalium peltatum Psacalium Asteraceae Asterales Magnoliopsida Streptophyta Viridiplantae Eukaryota
None Thalictrum Ranunculaceae Ranunculales Magnoliopsida Streptophyta Viridiplantae Eukaryota
None Thalictrum Ranunculaceae Ranunculales Magnoliopsida Streptophyta Viridiplantae Eukaryota

Properties Information

Molecule Weight: 194.254

TPSA？: 33.9

MolLogP？: -0.0284000000000002

Number of H-Donors: 2

Number of H-Acceptors: 2

RingCount: 2

Activities Information

Organism Target Name Standard Type Standard Value Standard Units doi
Homo sapiens Neuronal acetylcholine receptor protein alpha-7 subunit EC50 100000.0 nM 10.1021/acs.jmedchem.7b01895
Homo sapiens Neuronal acetylcholine receptor protein alpha-7 subunit IC50 100000.0 nM 10.1021/acs.jmedchem.7b01895
Mus musculus Nicotinic acetylcholine receptor alpha-4/beta-2 IC50 4400.0 nM 10.1021/acs.jmedchem.7b01895
Mus musculus Nicotinic acetylcholine receptor alpha-4/beta-2 IC50 4400.0 nM 10.1021/jm4013592
Rattus norvegicus Neuronal acetylcholine receptor; alpha3/beta4 IC50 100000.0 nM 10.1021/acs.jmedchem.7b01895
Rattus norvegicus Neuronal acetylcholine receptor; alpha3/beta4 IC50 1000000.0 nM 10.1021/jm4013592
Rattus norvegicus Neuronal acetylcholine receptor; alpha3/beta4 Ki 100000.0 nM 10.1021/acs.jmedchem.7b01895
Rattus norvegicus Neuronal acetylcholine receptor; alpha3/beta4 Ki 300000.0 nM 10.1021/jm4013592
Rattus norvegicus Neuronal acetylcholine receptor; alpha4/beta2 Inhibition nan % 10.1021/jm4013592
Rattus norvegicus Neuronal acetylcholine receptor; alpha4/beta2 Ki 1700.0 nM 10.1021/acs.jmedchem.7b01895
Rattus norvegicus Neuronal acetylcholine receptor; alpha4/beta2 Ki 1700.0 nM 10.1021/jm4013592
Rattus norvegicus Neuronal acetylcholine receptor; alpha4/beta4 Ki 100000.0 nM 10.1021/acs.jmedchem.7b01895
Rattus norvegicus Neuronal acetylcholine receptor; alpha4/beta4 Ki 100000.0 nM 10.1021/jm4013592
Saccharomyces cerevisiae S288c NAD-dependent deacetylase HST2 Activity 98.0 % 10.1016/j.bmc.2009.07.073
Saccharomyces cerevisiae S288c NAD-dependent deacetylase HST2 Activity 100.0 % 10.1016/j.bmc.2009.07.073
None Unchecked Ki 500000.0 nM 10.1021/jm4013592

Metabolism Information