Molecule

SF-2370

AlkaPlorer ID: AK020978

Synonym: None

IUPAC Name: methyl (15S,16R,18R)-16-hydroxy-15-methyl-3-oxo-28-oxa-4,14,19-triazaoctacyclo[12.11.2.115,18.02,6.07,27.08,13.019,26.020,25]octacosa-1,6,8,10,12,20,22,24,26-nonaene-16-carboxylate

Structure

SMILES: COC(=O)[C@@]1(O)C[C@H]2O[C@]1(C)N1C3=CC=CC=C3C3=C4CNC(=O)C4=C4C5=CC=CC=C5N2C4=C31

InChI: InChI=1S/C27H21N3O5/c1-26-27(33,25(32)34-2)11-18(35-26)29-16-9-5-3-7-13(16)20-21-15(12-28-24(21)31)19-14-8-4-6-10-17(14)30(26)23(19)22(20)29/h3-10,18,33H,11-12H2,1-2H3,(H,28,31)/t18-,26+,27+/m1/s1

InChIKey: KOZFSFOOLUUIGY-SOLYNIJKSA-N

Reference

K-252a, a potent inhibitor of protein kinase C from microbial origin.

PubChem CID: 3035817

CAS: 99533-80-9

LOTUS: LTS0265204

SuperNatural Ⅲ: SN0191517-08

NPASS: NPC94428

{

NPAtlas: NPA020870

Source

Species	Genus	Family	Order	Class	Phylum	Kingdom	Domain
Actinomadura sp.	Actinomadura	Thermomonosporaceae	Streptosporangiales	Actinomycetes	Actinomycetota	None	Bacteria

Properties Information

Molecule Weight: 467.4810000000003

TPSA？: 94.72

MolLogP？: 3.655100000000002

Number of H-Donors: 2

Number of H-Acceptors: 7

RingCount: 8

Activities Information

Organism	Target Name	Standard Type	Standard Value	Standard Units	doi
Gallus gallus	Myosin light chain kinase, smooth muscle	IC50	0.02	nM	10.1021/jm970031d
Homo sapiens	26S protease regulatory subunit 6B	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	3-phosphoinositide dependent protein kinase-1	Residual Activity	-1.0	%	10.1042/bj20121418
Homo sapiens	3-phosphoinositide dependent protein kinase-1	Residual Activity	0.0	%	10.1042/bj20121418
Homo sapiens	Actin-related protein 2	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	Actin-related protein 3	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	Activin receptor type-1	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	Activin receptor type-1B	Kd	15258.0	nM	10.1126/science.aan4368
Homo sapiens	Activin receptor type-1B	Residual Activity	0.0	%	10.1042/bj20121418
Homo sapiens	Activin receptor type-1B	Residual Activity	24.0	%	10.1042/bj20121418
Homo sapiens	Activin receptor type-2B	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	Acyl-CoA dehydrogenase family member 10	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	Acyl-CoA dehydrogenase family member 11	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	Adaptor-associated kinase	Kd	5.0	nM	10.1126/science.aan4368
Homo sapiens	Adenosine kinase	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	Adenylate kinase 2	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	ADP/ATP translocase 2	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	ADP/ATP translocase 3	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	ALK tyrosine kinase receptor	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	ALK tyrosine kinase receptor	Residual Activity	1.0	%	10.1042/bj20121418
Homo sapiens	ALK tyrosine kinase receptor	Residual Activity	10.0	%	10.1042/bj20121418
Homo sapiens	AMP-activated protein kinase, alpha-1 subunit	Kd	461.0	nM	10.1126/science.aan4368
Homo sapiens	AMP-activated protein kinase, AMPK	Residual Activity	-5.0	%	10.1042/bj20121418
Homo sapiens	AMP-activated protein kinase, AMPK	Residual Activity	1.0	%	10.1042/bj20121418
Homo sapiens	AMP-activated protein kinase (AMPK) alpha-1/beta-1/gamma-1	Residual Activity	-1.0	%	10.1042/bj20121418
Homo sapiens	AMP-activated protein kinase (AMPK) alpha-1/beta-1/gamma-1	Residual Activity	0.0	%	10.1042/bj20121418
Homo sapiens	AMP-activated protein kinase, gamma-1 subunit	Kd	352.0	nM	10.1126/science.aan4368
Homo sapiens	AMP-activated protein kinase, gamma-2 subunit	Kd	868.0	nM	10.1126/science.aan4368
Homo sapiens	ATP-dependent RNA helicase DDX1	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	ATP-dependent RNA helicase DDX3X	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	ATP-dependent RNA helicase DDX42	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	ATP-dependent RNA helicase DHX30	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	BMP-2-inducible protein kinase	Kd	90.0	nM	10.1126/science.aan4368
Homo sapiens	Bone morphogenetic protein receptor type-1A	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	Bone morphogenetic protein receptor type-1B	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	Bone morphogenetic protein receptor type-2	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	Brain glycogen phosphorylase	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	Breakpoint cluster region protein	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	BR serine/threonine-protein kinase 1	Residual Activity	-1.0	%	10.1042/bj20121418
Homo sapiens	BR serine/threonine-protein kinase 1	Residual Activity	0.0	%	10.1042/bj20121418
Homo sapiens	BR serine/threonine-protein kinase 2	Residual Activity	0.0	%	10.1042/bj20121418
Homo sapiens	BR serine/threonine-protein kinase 2	Residual Activity	1.0	%	10.1042/bj20121418
Homo sapiens	CaM kinase I alpha	Residual Activity	1.0	%	10.1042/bj20121418
Homo sapiens	CaM kinase I alpha	Residual Activity	6.0	%	10.1042/bj20121418
Homo sapiens	CaM kinase I delta	Residual Activity	0.0	%	10.1042/bj20121418
Homo sapiens	CaM kinase I delta	Residual Activity	5.0	%	10.1042/bj20121418
Homo sapiens	CaM kinase II beta	Residual Activity	-1.0	%	10.1042/bj20121418
Homo sapiens	CaM kinase II beta	Residual Activity	0.0	%	10.1042/bj20121418
Homo sapiens	CaM kinase II delta	Kd	190.0	nM	10.1126/science.aan4368
Homo sapiens	CaM kinase II delta	Residual Activity	0.0	%	10.1042/bj20121418
Homo sapiens	CaM kinase II delta	Residual Activity	1.0	%	10.1042/bj20121418
Homo sapiens	CaM kinase II gamma	Kd	173.0	nM	10.1126/science.aan4368
Homo sapiens	CaM kinase II gamma	Residual Activity	0.0	%	10.1042/bj20121418
Homo sapiens	CaM kinase II gamma	Residual Activity	1.0	%	10.1042/bj20121418
Homo sapiens	CaM kinase IV	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	CaM kinase IV	Residual Activity	11.0	%	10.1042/bj20121418
Homo sapiens	CaM kinase IV	Residual Activity	24.0	%	10.1042/bj20121418
Homo sapiens	CaM-kinase kinase beta	Kd	2277.0	nM	10.1126/science.aan4368
Homo sapiens	cAMP-dependent protein kinase alpha-catalytic subunit	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	cAMP-dependent protein kinase alpha-catalytic subunit	Residual Activity	3.0	%	10.1042/bj20121418
Homo sapiens	cAMP-dependent protein kinase alpha-catalytic subunit	Residual Activity	7.0	%	10.1042/bj20121418
Homo sapiens	cAMP-dependent protein kinase beta-1 catalytic subunit	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	cAMP-dependent protein kinase, gamma catalytic subunit	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	cAMP-dependent protein kinase (PKA)	IC50	nan	nM	10.1016/S0960-894X(00)80167-5
Homo sapiens	cAMP-dependent protein kinase type II-alpha regulatory subunit	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	Casein kinase I alpha	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	Casein kinase I delta	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	Casein kinase I delta	Residual Activity	37.0	%	10.1042/bj20121418
Homo sapiens	Casein kinase I delta	Residual Activity	79.0	%	10.1042/bj20121418
Homo sapiens	Casein kinase I epsilon	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	Casein kinase I gamma 1	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	Casein kinase I gamma 1	Residual Activity	57.0	%	10.1042/bj20121418
Homo sapiens	Casein kinase I gamma 1	Residual Activity	93.0	%	10.1042/bj20121418
Homo sapiens	Casein kinase I gamma 2	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	Casein kinase I gamma 2	Residual Activity	60.0	%	10.1042/bj20121418
Homo sapiens	Casein kinase I gamma 2	Residual Activity	101.0	%	10.1042/bj20121418
Homo sapiens	Casein kinase II	Residual Activity	82.0	%	10.1042/bj20121418
Homo sapiens	Casein kinase II	Residual Activity	93.0	%	10.1042/bj20121418
Homo sapiens	Casein kinase II alpha (prime)	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	Casein kinase II alpha (prime)	Residual Activity	90.0	%	10.1042/bj20121418
Homo sapiens	Casein kinase II alpha (prime)	Residual Activity	108.0	%	10.1042/bj20121418
Homo sapiens	Casein kinase I isoform gamma-3	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	Casein kinase I isoform gamma-3	Residual Activity	58.0	%	10.1042/bj20121418
Homo sapiens	Casein kinase I isoform gamma-3	Residual Activity	99.0	%	10.1042/bj20121418
Homo sapiens	CDK3/cyclin E	Residual Activity	2.0	%	10.1042/bj20121418
Homo sapiens	CDK3/cyclin E	Residual Activity	27.0	%	10.1042/bj20121418
Homo sapiens	CDK6/cyclin D3	Residual Activity	4.0	%	10.1042/bj20121418
Homo sapiens	CDK6/cyclin D3	Residual Activity	15.0	%	10.1042/bj20121418
Homo sapiens	CDK9/cyclin T1	Residual Activity	2.0	%	10.1042/bj20121418
Homo sapiens	CDK9/cyclin T1	Residual Activity	10.0	%	10.1042/bj20121418
Homo sapiens	cGMP-dependent protein kinase 1 beta	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	cGMP-dependent protein kinase 1 beta	Residual Activity	1.0	%	10.1042/bj20121418
Homo sapiens	cGMP-dependent protein kinase 1 beta	Residual Activity	2.0	%	10.1042/bj20121418
Homo sapiens	cGMP-dependent protein kinase 1 beta	Residual Activity	9.0	%	10.1042/bj20121418
Homo sapiens	cGMP-dependent protein kinase 1 beta	Residual Activity	10.0	%	10.1042/bj20121418
Homo sapiens	Chaperone activity of bc1 complex-like, mitochondrial	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	Chromodomain-helicase-DNA-binding protein 4	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	Citron Rho-interacting kinase	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	c-Jun N-terminal kinase 1	Kd	551.0	nM	10.1126/science.aan4368
Homo sapiens	c-Jun N-terminal kinase 1	Residual Activity	-20.0	%	10.1042/bj20121418
Homo sapiens	c-Jun N-terminal kinase 1	Residual Activity	-12.0	%	10.1042/bj20121418
Homo sapiens	c-Jun N-terminal kinase 2	Kd	986.0	nM	10.1126/science.aan4368
Homo sapiens	c-Jun N-terminal kinase 2	Residual Activity	-11.0	%	10.1042/bj20121418
Homo sapiens	c-Jun N-terminal kinase 2	Residual Activity	5.0	%	10.1042/bj20121418
Homo sapiens	c-Jun N-terminal kinase 3	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	c-Jun N-terminal kinase 3	Residual Activity	-3.0	%	10.1042/bj20121418
Homo sapiens	c-Jun N-terminal kinase 3	Residual Activity	-1.0	%	10.1042/bj20121418
Homo sapiens	Cyclin-dependent kinase 1	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	Cyclin-dependent kinase 10	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	Cyclin-dependent kinase 12	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	Cyclin-dependent kinase 13	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	Cyclin-dependent kinase 1/cyclin B1	Residual Activity	-1.0	%	10.1042/bj20121418
Homo sapiens	Cyclin-dependent kinase 1/cyclin B1	Residual Activity	5.0	%	10.1042/bj20121418
Homo sapiens	Cyclin-dependent kinase 2	Kd	101.0	nM	10.1126/science.aan4368
Homo sapiens	Cyclin-dependent kinase 2/cyclin A	Residual Activity	0.0	%	10.1042/bj20121418
Homo sapiens	Cyclin-dependent kinase 2/cyclin A	Residual Activity	1.0	%	10.1042/bj20121418
Homo sapiens	Cyclin-dependent kinase 2/cyclin E	Residual Activity	0.0	%	10.1042/bj20121418
Homo sapiens	Cyclin-dependent kinase 2/cyclin E	Residual Activity	6.0	%	10.1042/bj20121418
Homo sapiens	Cyclin-dependent kinase 3	Kd	32.0	nM	10.1126/science.aan4368
Homo sapiens	Cyclin-dependent kinase 4	Kd	14.0	nM	10.1126/science.aan4368
Homo sapiens	Cyclin-dependent kinase 5	Kd	911.0	nM	10.1126/science.aan4368
Homo sapiens	Cyclin-dependent kinase 5/CDK5 activator 1	Residual Activity	1.0	%	10.1042/bj20121418
Homo sapiens	Cyclin-dependent kinase 5/CDK5 activator 1	Residual Activity	3.0	%	10.1042/bj20121418
Homo sapiens	Cyclin-dependent kinase 5/CDK5 activator 1	Residual Activity	4.0	%	10.1042/bj20121418
Homo sapiens	Cyclin-dependent kinase 6	Kd	399.0	nM	10.1126/science.aan4368
Homo sapiens	Cyclin-dependent kinase 7	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	Cyclin-dependent kinase 7/ cyclin H	Residual Activity	16.0	%	10.1042/bj20121418
Homo sapiens	Cyclin-dependent kinase 7/ cyclin H	Residual Activity	55.0	%	10.1042/bj20121418
Homo sapiens	Cyclin-dependent kinase 9	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	Cyclin-dependent kinase-like 5	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	Cytochrome c1, heme protein, mitochondrial	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	dCTP pyrophosphatase 1	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	Death-associated protein kinase 1	Residual Activity	10.0	%	10.1042/bj20121418
Homo sapiens	Death-associated protein kinase 1	Residual Activity	48.0	%	10.1042/bj20121418
Homo sapiens	Death-associated protein kinase 2	Residual Activity	-3.0	%	10.1042/bj20121418
Homo sapiens	Death-associated protein kinase 2	Residual Activity	12.0	%	10.1042/bj20121418
Homo sapiens	Death-associated protein kinase 3	Residual Activity	2.0	%	10.1042/bj20121418
Homo sapiens	Death-associated protein kinase 3	Residual Activity	12.0	%	10.1042/bj20121418
Homo sapiens	Delta(24)-sterol reductase	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	Deoxycytidine kinase	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	Discoidin domain-containing receptor 2	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	Discoidin domain-containing receptor 2	Residual Activity	17.0	%	10.1042/bj20121418
Homo sapiens	Discoidin domain-containing receptor 2	Residual Activity	56.0	%	10.1042/bj20121418
Homo sapiens	DnaJ homolog subfamily A member 1	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	DNA replication licensing factor MCM4	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	DNA topoisomerase II alpha	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	DNA topoisomerase II beta	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	Dual specificity mitogen-activated protein kinase kinase 1	Kd	1747.0	nM	10.1126/science.aan4368
Homo sapiens	Dual specificity mitogen-activated protein kinase kinase 1	Residual Activity	0.0	%	10.1042/bj20121418
Homo sapiens	Dual specificity mitogen-activated protein kinase kinase 2	Kd	474.0	nM	10.1126/science.aan4368
Homo sapiens	Dual specificity mitogen-activated protein kinase kinase 3	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	Dual specificity mitogen-activated protein kinase kinase 4	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	Dual specificity mitogen-activated protein kinase kinase 5	Kd	2033.0	nM	10.1126/science.aan4368
Homo sapiens	Dual specificity mitogen-activated protein kinase kinase 6	Kd	88.0	nM	10.1126/science.aan4368
Homo sapiens	Dual specificity mitogen-activated protein kinase kinase 6	Residual Activity	0.0	%	10.1042/bj20121418
Homo sapiens	Dual specificity mitogen-activated protein kinase kinase 6	Residual Activity	26.0	%	10.1042/bj20121418
Homo sapiens	Dual specificity mitogen-activated protein kinase kinase 7	Residual Activity	0.0	%	10.1042/bj20121418
Homo sapiens	Dual specificity mitogen-activated protein kinase kinase 7	Residual Activity	7.0	%	10.1042/bj20121418
Homo sapiens	Dual specificity protein kinase CLK2	Kd	3809.0	nM	10.1126/science.aan4368
Homo sapiens	Dual specificity protein kinase CLK2	Residual Activity	1.0	%	10.1042/bj20121418
Homo sapiens	Dual specificity protein kinase CLK2	Residual Activity	4.0	%	10.1042/bj20121418
Homo sapiens	Dual specificity protein kinase CLK3	Residual Activity	33.0	%	10.1042/bj20121418
Homo sapiens	Dual specificity protein kinase CLK3	Residual Activity	72.0	%	10.1042/bj20121418
Homo sapiens	Dual specificity protein kinase CLK4	Kd	15.0	nM	10.1126/science.aan4368
Homo sapiens	Dual specificity protein kinase TTK	Kd	30.0	nM	10.1126/science.aan4368
Homo sapiens	Dual specificity testis-specific protein kinase 1	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	Dual specificity testis-specific protein kinase 2	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	Dual-specificity tyrosine-phosphorylation regulated kinase 1A	Kd	4852.0	nM	10.1126/science.aan4368
Homo sapiens	Dual specificity tyrosine-phosphorylation-regulated kinase 1B	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	Dual-specificity tyrosine-phosphorylation regulated kinase 2	Residual Activity	-4.0	%	10.1042/bj20121418
Homo sapiens	Dual-specificity tyrosine-phosphorylation regulated kinase 2	Residual Activity	2.0	%	10.1042/bj20121418
Homo sapiens	Dual specificty protein kinase CLK1	Kd	10.0	nM	10.1126/science.aan4368
Homo sapiens	Dynamin-like 120 kDa protein, mitochondrial	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	Electron transfer flavoprotein subunit beta	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	Elongation factor Tu, mitochondrial	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	Ephrin type-A receptor 1	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	Ephrin type-A receptor 1	Residual Activity	0.0	%	10.1042/bj20121418
Homo sapiens	Ephrin type-A receptor 1	Residual Activity	3.0	%	10.1042/bj20121418
Homo sapiens	Ephrin type-A receptor 2	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	Ephrin type-A receptor 2	Residual Activity	8.0	%	10.1042/bj20121418
Homo sapiens	Ephrin type-A receptor 2	Residual Activity	44.0	%	10.1042/bj20121418
Homo sapiens	Ephrin type-A receptor 3	Residual Activity	5.0	%	10.1042/bj20121418
Homo sapiens	Ephrin type-A receptor 3	Residual Activity	42.0	%	10.1042/bj20121418
Homo sapiens	Ephrin type-A receptor 4	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	Ephrin type-A receptor 4	Residual Activity	43.0	%	10.1042/bj20121418
Homo sapiens	Ephrin type-A receptor 4	Residual Activity	83.0	%	10.1042/bj20121418
Homo sapiens	Ephrin type-A receptor 5	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	Ephrin type-A receptor 5	Residual Activity	13.0	%	10.1042/bj20121418
Homo sapiens	Ephrin type-A receptor 5	Residual Activity	66.0	%	10.1042/bj20121418
Homo sapiens	Ephrin type-A receptor 7	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	Ephrin type-A receptor 7	Residual Activity	4.0	%	10.1042/bj20121418
Homo sapiens	Ephrin type-A receptor 7	Residual Activity	32.0	%	10.1042/bj20121418
Homo sapiens	Ephrin type-A receptor 8	Residual Activity	40.0	%	10.1042/bj20121418
Homo sapiens	Ephrin type-A receptor 8	Residual Activity	78.0	%	10.1042/bj20121418
Homo sapiens	Ephrin type-B receptor 1	Residual Activity	4.0	%	10.1042/bj20121418
Homo sapiens	Ephrin type-B receptor 1	Residual Activity	39.0	%	10.1042/bj20121418
Homo sapiens	Ephrin type-B receptor 2	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	Ephrin type-B receptor 2	Residual Activity	55.0	%	10.1042/bj20121418
Homo sapiens	Ephrin type-B receptor 2	Residual Activity	114.0	%	10.1042/bj20121418
Homo sapiens	Ephrin type-B receptor 3	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	Ephrin type-B receptor 3	Residual Activity	100.0	%	10.1042/bj20121418
Homo sapiens	Ephrin type-B receptor 3	Residual Activity	110.0	%	10.1042/bj20121418
Homo sapiens	Ephrin type-B receptor 4	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	Ephrin type-B receptor 4	Residual Activity	22.0	%	10.1042/bj20121418
Homo sapiens	Ephrin type-B receptor 4	Residual Activity	71.0	%	10.1042/bj20121418
Homo sapiens	Ephrin type-B receptor 6	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	Epidermal growth factor receptor erbB1	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	Epidermal growth factor receptor erbB1	Residual Activity	47.0	%	10.1042/bj20121418
Homo sapiens	Epidermal growth factor receptor erbB1	Residual Activity	72.0	%	10.1042/bj20121418
Homo sapiens	Epithelial discoidin domain-containing receptor 1	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	Eukaryotic translation initiation factor 2-alpha kinase 1	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	Eukaryotic translation initiation factor 5B	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	Exosome RNA helicase MTR4	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	Ferrochelatase, mitochondrial	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	Fibroblast growth factor receptor 1	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	Fibroblast growth factor receptor 1	Residual Activity	10.0	%	10.1042/bj20121418
Homo sapiens	Fibroblast growth factor receptor 1	Residual Activity	11.0	%	10.1042/bj20121418
Homo sapiens	Fibroblast growth factor receptor 2	Residual Activity	2.0	%	10.1042/bj20121418
Homo sapiens	Fibroblast growth factor receptor 2	Residual Activity	20.0	%	10.1042/bj20121418
Homo sapiens	Fibroblast growth factor receptor 3	Residual Activity	2.0	%	10.1042/bj20121418
Homo sapiens	Fibroblast growth factor receptor 3	Residual Activity	17.0	%	10.1042/bj20121418
Homo sapiens	Fibroblast growth factor receptor 4	Residual Activity	36.0	%	10.1042/bj20121418
Homo sapiens	Fibroblast growth factor receptor 4	Residual Activity	88.0	%	10.1042/bj20121418
Homo sapiens	Focal adhesion kinase 1	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	Focal adhesion kinase 1	Residual Activity	5.0	%	10.1042/bj20121418
Homo sapiens	Focal adhesion kinase 1	Residual Activity	39.0	%	10.1042/bj20121418
Homo sapiens	General transcription and DNA repair factor IIH helicase subunit XPD	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	Glycine--tRNA ligase	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	Glycogen synthase kinase-3 alpha	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	Glycogen synthase kinase-3 alpha	Residual Activity	3.0	%	10.1042/bj20121418
Homo sapiens	Glycogen synthase kinase-3 alpha	Residual Activity	14.0	%	10.1042/bj20121418
Homo sapiens	Glycogen synthase kinase-3 beta	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	Glycogen synthase kinase-3 beta	Residual Activity	10.0	%	10.1042/bj20121418
Homo sapiens	Glycogen synthase kinase-3 beta	Residual Activity	29.0	%	10.1042/bj20121418
Homo sapiens	G-protein coupled receptor kinase 2	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	G protein-coupled receptor kinase 5	Residual Activity	5.0	%	10.1042/bj20121418
Homo sapiens	G protein-coupled receptor kinase 5	Residual Activity	40.0	%	10.1042/bj20121418
Homo sapiens	G protein-coupled receptor kinase 6	Residual Activity	5.0	%	10.1042/bj20121418
Homo sapiens	G protein-coupled receptor kinase 6	Residual Activity	36.0	%	10.1042/bj20121418
Homo sapiens	G protein-coupled receptor kinase 7	Residual Activity	4.0	%	10.1042/bj20121418
Homo sapiens	GTP-binding nuclear protein Ran	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	Heme oxygenase 2	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	Hepatocyte growth factor receptor	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	Hepatocyte growth factor receptor	Residual Activity	6.0	%	10.1042/bj20121418
Homo sapiens	Hepatocyte growth factor receptor	Residual Activity	13.0	%	10.1042/bj20121418
Homo sapiens	Homeodomain-interacting protein kinase 1	Residual Activity	15.0	%	10.1042/bj20121418
Homo sapiens	Homeodomain-interacting protein kinase 1	Residual Activity	78.0	%	10.1042/bj20121418
Homo sapiens	Homeodomain-interacting protein kinase 2	Residual Activity	-1.0	%	10.1042/bj20121418
Homo sapiens	Homeodomain-interacting protein kinase 2	Residual Activity	22.0	%	10.1042/bj20121418
Homo sapiens	Homeodomain-interacting protein kinase 3	Residual Activity	-4.0	%	10.1042/bj20121418
Homo sapiens	Homeodomain-interacting protein kinase 3	Residual Activity	54.0	%	10.1042/bj20121418
Homo sapiens	Inhibitor of nuclear factor kappa B kinase alpha subunit	Residual Activity	2.0	%	10.1042/bj20121418
Homo sapiens	Inhibitor of nuclear factor kappa B kinase alpha subunit	Residual Activity	3.0	%	10.1042/bj20121418
Homo sapiens	Inhibitor of nuclear factor kappa B kinase beta subunit	Residual Activity	3.0	%	10.1042/bj20121418
Homo sapiens	Inhibitor of nuclear factor kappa B kinase beta subunit	Residual Activity	17.0	%	10.1042/bj20121418
Homo sapiens	Inhibitor of nuclear factor kappa B kinase epsilon subunit	Kd	494.0	nM	10.1126/science.aan4368
Homo sapiens	Inosine-5'-monophosphate dehydrogenase 2	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	Insulin-like growth factor I receptor	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	Insulin-like growth factor I receptor	Residual Activity	3.0	%	10.1042/bj20121418
Homo sapiens	Insulin-like growth factor I receptor	Residual Activity	14.0	%	10.1042/bj20121418
Homo sapiens	Insulin-like growth factor I receptor	Residual Activity	23.0	%	10.1042/bj20121418
Homo sapiens	Insulin-like growth factor I receptor	Residual Activity	77.0	%	10.1042/bj20121418
Homo sapiens	Insulin receptor	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	Insulin receptor	Residual Activity	0.0	%	10.1042/bj20121418
Homo sapiens	Insulin receptor	Residual Activity	7.0	%	10.1042/bj20121418
Homo sapiens	Insulin receptor	Residual Activity	20.0	%	10.1042/bj20121418
Homo sapiens	Insulin receptor	Residual Activity	42.0	%	10.1042/bj20121418
Homo sapiens	Insulin receptor-related protein	Residual Activity	1.0	%	10.1042/bj20121418
Homo sapiens	Insulin receptor-related protein	Residual Activity	6.0	%	10.1042/bj20121418
Homo sapiens	Interleukin-1 receptor-associated kinase 1	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	Interleukin-1 receptor-associated kinase 1	Residual Activity	0.0	%	10.1042/bj20121418
Homo sapiens	Interleukin-1 receptor-associated kinase 1	Residual Activity	1.0	%	10.1042/bj20121418
Homo sapiens	Interleukin-1 receptor-associated kinase 3	Kd	254.0	nM	10.1126/science.aan4368
Homo sapiens	Interleukin-1 receptor-associated kinase 4	Kd	9.0	nM	10.1126/science.aan4368
Homo sapiens	Interleukin-1 receptor-associated kinase 4	Residual Activity	-2.0	%	10.1042/bj20121418
Homo sapiens	Interleukin-1 receptor-associated kinase 4	Residual Activity	0.0	%	10.1042/bj20121418
Homo sapiens	LIM domain kinase 1	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	LIM domain kinase 1	Residual Activity	3.0	%	10.1042/bj20121418
Homo sapiens	LIM domain kinase 1	Residual Activity	6.0	%	10.1042/bj20121418
Homo sapiens	LIM domain kinase 2	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	Liver glycogen phosphorylase	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	Long-chain-fatty-acid--CoA ligase 5	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	Macrophage colony stimulating factor receptor	Residual Activity	1.0	%	10.1042/bj20121418
Homo sapiens	Macrophage colony stimulating factor receptor	Residual Activity	2.0	%	10.1042/bj20121418
Homo sapiens	Macrophage-stimulating protein receptor	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	Macrophage-stimulating protein receptor	Residual Activity	3.0	%	10.1042/bj20121418
Homo sapiens	Macrophage-stimulating protein receptor	Residual Activity	33.0	%	10.1042/bj20121418
Homo sapiens	MAP kinase-activated protein kinase 2	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	MAP kinase-activated protein kinase 2	Residual Activity	-6.0	%	10.1042/bj20121418
Homo sapiens	MAP kinase-activated protein kinase 2	Residual Activity	0.0	%	10.1042/bj20121418
Homo sapiens	MAP kinase-activated protein kinase 3	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	MAP kinase-activated protein kinase 3	Residual Activity	2.0	%	10.1042/bj20121418
Homo sapiens	MAP kinase-activated protein kinase 3	Residual Activity	47.0	%	10.1042/bj20121418
Homo sapiens	MAP kinase-activated protein kinase 5	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	MAP kinase-activated protein kinase 5	Residual Activity	0.0	%	10.1042/bj20121418
Homo sapiens	MAP kinase-activated protein kinase 5	Residual Activity	19.0	%	10.1042/bj20121418
Homo sapiens	MAP kinase ERK1	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	MAP kinase ERK1	Residual Activity	-1.0	%	10.1042/bj20121418
Homo sapiens	MAP kinase ERK1	Residual Activity	10.0	%	10.1042/bj20121418
Homo sapiens	MAP kinase ERK2	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	MAP kinase ERK2	Residual Activity	-3.0	%	10.1042/bj20121418
Homo sapiens	MAP kinase ERK2	Residual Activity	5.0	%	10.1042/bj20121418
Homo sapiens	MAP kinase p38 alpha	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	MAP kinase p38 alpha	Residual Activity	67.0	%	10.1042/bj20121418
Homo sapiens	MAP kinase p38 alpha	Residual Activity	92.0	%	10.1042/bj20121418
Homo sapiens	MAP kinase p38 beta	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	MAP kinase p38 beta	Residual Activity	29.0	%	10.1042/bj20121418
Homo sapiens	MAP kinase p38 beta	Residual Activity	77.0	%	10.1042/bj20121418
Homo sapiens	MAP kinase p38 delta	Residual Activity	10.0	%	10.1042/bj20121418
Homo sapiens	MAP kinase p38 delta	Residual Activity	58.0	%	10.1042/bj20121418
Homo sapiens	MAP kinase p38 gamma	Residual Activity	2.0	%	10.1042/bj20121418
Homo sapiens	MAP kinase p38 gamma	Residual Activity	23.0	%	10.1042/bj20121418
Homo sapiens	MAP kinase signal-integrating kinase 2	Residual Activity	0.0	%	10.1042/bj20121418
Homo sapiens	MAP/microtubule affinity-regulating kinase 2	Kd	704.0	nM	10.1126/science.aan4368
Homo sapiens	MAP/microtubule affinity-regulating kinase 2	Residual Activity	-2.0	%	10.1042/bj20121418
Homo sapiens	MAP/microtubule affinity-regulating kinase 2	Residual Activity	1.0	%	10.1042/bj20121418
Homo sapiens	MAP/microtubule affinity-regulating kinase 4	Kd	28.0	nM	10.1126/science.aan4368
Homo sapiens	Maternal embryonic leucine zipper kinase	Kd	83.0	nM	10.1126/science.aan4368
Homo sapiens	Maternal embryonic leucine zipper kinase	Residual Activity	-1.0	%	10.1042/bj20121418
Homo sapiens	Maternal embryonic leucine zipper kinase	Residual Activity	1.0	%	10.1042/bj20121418
Homo sapiens	Membrane-associated progesterone receptor component 1	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	Midasin	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	Misshapen-like kinase 1	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	Misshapen-like kinase 1	Residual Activity	0.0	%	10.1042/bj20121418
Homo sapiens	Misshapen-like kinase 1	Residual Activity	1.0	%	10.1042/bj20121418
Homo sapiens	Mitogen-activated protein kinase 15	Kd	167.0	nM	10.1126/science.aan4368
Homo sapiens	Mitogen-activated protein kinase 7	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	Mitogen-activated protein kinase kinase kinase 1	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	Mitogen-activated protein kinase kinase kinase 11	Kd	572.0	nM	10.1126/science.aan4368
Homo sapiens	Mitogen-activated protein kinase kinase kinase 2	Kd	4118.0	nM	10.1126/science.aan4368
Homo sapiens	Mitogen-activated protein kinase kinase kinase 3	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	Mitogen-activated protein kinase kinase kinase 4	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	Mitogen-activated protein kinase kinase kinase 5	Kd	182.0	nM	10.1126/science.aan4368
Homo sapiens	Mitogen-activated protein kinase kinase kinase 5	Residual Activity	0.0	%	10.1042/bj20121418
Homo sapiens	Mitogen-activated protein kinase kinase kinase 6	Kd	335.0	nM	10.1126/science.aan4368
Homo sapiens	Mitogen-activated protein kinase kinase kinase 7	Residual Activity	-5.0	%	10.1042/bj20121418
Homo sapiens	Mitogen-activated protein kinase kinase kinase 7	Residual Activity	-1.0	%	10.1042/bj20121418
Homo sapiens	Mitogen-activated protein kinase kinase kinase 9	Residual Activity	0.0	%	10.1042/bj20121418
Homo sapiens	Mitogen-activated protein kinase kinase kinase 9	Residual Activity	1.0	%	10.1042/bj20121418
Homo sapiens	Mitogen-activated protein kinase kinase kinase kinase 1	Kd	452.0	nM	10.1126/science.aan4368
Homo sapiens	Mitogen-activated protein kinase kinase kinase kinase 2	Kd	131.0	nM	10.1126/science.aan4368
Homo sapiens	Mitogen-activated protein kinase kinase kinase kinase 2	Residual Activity	0.0	%	10.1042/bj20121418
Homo sapiens	Mitogen-activated protein kinase kinase kinase kinase 2	Residual Activity	1.0	%	10.1042/bj20121418
Homo sapiens	Mitogen-activated protein kinase kinase kinase kinase 3	Kd	2374.0	nM	10.1126/science.aan4368
Homo sapiens	Mitogen-activated protein kinase kinase kinase kinase 4	Kd	19.0	nM	10.1126/science.aan4368
Homo sapiens	Mitogen-activated protein kinase kinase kinase kinase 5	Kd	193.0	nM	10.1126/science.aan4368
Homo sapiens	Mitotic checkpoint serine/threonine-protein kinase BUB1	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	Mixed lineage kinase 7	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	Multifunctional protein ADE2	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	Muscle, skeletal receptor tyrosine protein kinase	Residual Activity	2.0	%	10.1042/bj20121418
Homo sapiens	Muscle, skeletal receptor tyrosine protein kinase	Residual Activity	18.0	%	10.1042/bj20121418
Homo sapiens	Myelin transcription factor 1	Activity	5.0	%	10.1016/j.ejmech.2012.06.007
Homo sapiens	Myelin transcription factor 1	IC50	nan	None	10.1016/j.ejmech.2012.06.007
Homo sapiens	Myosin-14	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	Myosin light chain kinase	Kd	98.0	nM	10.1126/science.aan4368
Homo sapiens	Myosin light chain kinase, smooth muscle	IC50	22.0	nM	10.1016/s0960-894x(02)00638-8
Homo sapiens	Myosin light chain kinase, smooth muscle	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	Myosin light chain kinase, smooth muscle	Ki	20.0	nM	10.1016/j.bmc.2010.11.007
Homo sapiens	Myosin light chain kinase, smooth muscle	Residual Activity	1.0	%	10.1042/bj20121418
Homo sapiens	Myosin light chain kinase, smooth muscle	Residual Activity	2.0	%	10.1042/bj20121418
Homo sapiens	Myotonin-protein kinase	Residual Activity	65.0	%	10.1042/bj20121418
Homo sapiens	Myotonin-protein kinase	Residual Activity	116.0	%	10.1042/bj20121418
Homo sapiens	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	Nerve growth factor receptor Trk-A	IC50	2.4	nM	10.1021/jm970031d
Homo sapiens	Nerve growth factor receptor Trk-A	IC50	13.0	nM	10.1016/s0960-894x(02)00638-8
Homo sapiens	Nerve growth factor receptor Trk-A	IC50	13.0	nM	10.1021/jm040178m
Homo sapiens	Nerve growth factor receptor Trk-A	IC50	25.0	nM	10.1039/d2md00067a
Homo sapiens	Nerve growth factor receptor Trk-A	Kd	1739.0	nM	10.1126/science.aan4368
Homo sapiens	Nerve growth factor receptor Trk-A	Residual Activity	0.0	%	10.1042/bj20121418
Homo sapiens	Nerve growth factor receptor Trk-A	Residual Activity	1.0	%	10.1042/bj20121418
Homo sapiens	Neurotrophic tyrosine kinase receptor type 2	Residual Activity	0.0	%	10.1042/bj20121418
Homo sapiens	Non-receptor tyrosine-protein kinase TNK1	Kd	287.0	nM	10.1126/science.aan4368
Homo sapiens	NUAK family SNF1-like kinase 1	Residual Activity	1.0	%	10.1042/bj20121418
Homo sapiens	NUAK family SNF1-like kinase 2	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	Nucleolar GTP-binding protein 1	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	PAS domain-containing serine/threonine-protein kinase	Residual Activity	4.0	%	10.1042/bj20121418
Homo sapiens	PAS domain-containing serine/threonine-protein kinase	Residual Activity	14.0	%	10.1042/bj20121418
Homo sapiens	Peroxisomal acyl-coenzyme A oxidase 1	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	Peroxisomal acyl-coenzyme A oxidase 3	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	Phenylalanine--tRNA ligase beta subunit	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	Phosphatidylinositol-5-phosphate 4-kinase type-2 alpha	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	Phosphatidylinositol-5-phosphate 4-kinase type-2 gamma	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	Phosphofructokinase platelet type	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	Phosphorylase kinase	IC50	1.7	nM	10.1021/acs.jmedchem.8b00294
Homo sapiens	Phosphorylase kinase	IC50	1.7	nM	10.1021/jm00079a024
Homo sapiens	Phosphorylase kinase gamma subunit 2	Kd	3263.0	nM	10.1126/science.aan4368
Homo sapiens	Phosphorylase kinase gamma subunit 2	Residual Activity	0.0	%	10.1042/bj20121418
Homo sapiens	Phosphorylase kinase gamma subunit 2	Residual Activity	1.0	%	10.1042/bj20121418
Homo sapiens	Platelet-derived growth factor receptor alpha	Residual Activity	8.0	%	10.1042/bj20121418
Homo sapiens	Platelet-derived growth factor receptor alpha	Residual Activity	32.0	%	10.1042/bj20121418
Homo sapiens	Platelet-derived growth factor receptor beta	Kd	1006.0	nM	10.1126/science.aan4368
Homo sapiens	Platelet-derived growth factor receptor beta	Residual Activity	8.0	%	10.1042/bj20121418
Homo sapiens	Platelet-derived growth factor receptor beta	Residual Activity	46.0	%	10.1042/bj20121418
Homo sapiens	Probable ATP-dependent RNA helicase DDX6	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	Protein kinase C alpha	Kd	2280.0	nM	10.1126/science.aan4368
Homo sapiens	Protein kinase C alpha	Residual Activity	0.0	%	10.1042/bj20121418
Homo sapiens	Protein kinase C alpha	Residual Activity	19.0	%	10.1042/bj20121418
Homo sapiens	Protein kinase C beta	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	Protein kinase C beta	Residual Activity	13.0	%	10.1042/bj20121418
Homo sapiens	Protein kinase C beta	Residual Activity	18.0	%	10.1042/bj20121418
Homo sapiens	Protein kinase C beta	Residual Activity	53.0	%	10.1042/bj20121418
Homo sapiens	Protein kinase C beta	Residual Activity	67.0	%	10.1042/bj20121418
Homo sapiens	Protein kinase C delta	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	Protein kinase C delta	Residual Activity	3.0	%	10.1042/bj20121418
Homo sapiens	Protein kinase C delta	Residual Activity	18.0	%	10.1042/bj20121418
Homo sapiens	Protein kinase C epsilon	Residual Activity	10.0	%	10.1042/bj20121418
Homo sapiens	Protein kinase C epsilon	Residual Activity	51.0	%	10.1042/bj20121418
Homo sapiens	Protein kinase C eta	Residual Activity	7.0	%	10.1042/bj20121418
Homo sapiens	Protein kinase C eta	Residual Activity	36.0	%	10.1042/bj20121418
Homo sapiens	Protein kinase C gamma	Residual Activity	2.0	%	10.1042/bj20121418
Homo sapiens	Protein kinase C gamma	Residual Activity	19.0	%	10.1042/bj20121418
Homo sapiens	Protein kinase C iota	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	Protein kinase C iota	Residual Activity	69.0	%	10.1042/bj20121418
Homo sapiens	Protein kinase C iota	Residual Activity	107.0	%	10.1042/bj20121418
Homo sapiens	Protein kinase C mu	Residual Activity	0.0	%	10.1042/bj20121418
Homo sapiens	Protein kinase C mu	Residual Activity	1.0	%	10.1042/bj20121418
Homo sapiens	Protein kinase C nu	Kd	38.0	nM	10.1126/science.aan4368
Homo sapiens	Protein kinase C (PKC)	IC50	25.0	nM	10.1016/S0960-894X(01)80407-8
Homo sapiens	Protein kinase C (PKC)	IC50	33.0	nM	10.1016/S0960-894X(00)80167-5
Homo sapiens	Protein kinase C (PKC)	IC50	60.0	nM	10.1016/0960-894X(94)80024-3
Homo sapiens	Protein kinase C (PKC)	IC50	250.0	nM	10.1016/s0960-894x(02)00638-8
Homo sapiens	Protein kinase C theta	IC50	530.0	nM	10.1021/acs.jmedchem.0c01271
Homo sapiens	Protein kinase C theta	Inhibition	50.0	%	10.1021/acs.jmedchem.0c01271
Homo sapiens	Protein kinase C theta	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	Protein kinase C theta	Residual Activity	5.0	%	10.1042/bj20121418
Homo sapiens	Protein kinase C theta	Residual Activity	10.0	%	10.1042/bj20121418
Homo sapiens	Protein kinase C zeta	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	Protein kinase C zeta	Residual Activity	8.0	%	10.1042/bj20121418
Homo sapiens	Protein kinase C zeta	Residual Activity	52.0	%	10.1042/bj20121418
Homo sapiens	Protein kinase N1	Kd	264.0	nM	10.1126/science.aan4368
Homo sapiens	Protein kinase N2	Kd	361.0	nM	10.1126/science.aan4368
Homo sapiens	Protein kinase N2	Residual Activity	1.0	%	10.1042/bj20121418
Homo sapiens	Protein tyrosine kinase 2 beta	Kd	1360.0	nM	10.1126/science.aan4368
Homo sapiens	Protein tyrosine kinase 2 beta	Residual Activity	-1.0	%	10.1042/bj20121418
Homo sapiens	Protein tyrosine kinase 2 beta	Residual Activity	3.0	%	10.1042/bj20121418
Homo sapiens	Proto-oncogene tyrosine-protein kinase MER	Kd	41.0	nM	10.1126/science.aan4368
Homo sapiens	Proto-oncogene tyrosine-protein kinase MER	Residual Activity	0.0	%	10.1042/bj20121418
Homo sapiens	Proto-oncogene tyrosine-protein kinase MER	Residual Activity	2.0	%	10.1042/bj20121418
Homo sapiens	Proto-oncogene tyrosine-protein kinase ROS	Residual Activity	3.0	%	10.1042/bj20121418
Homo sapiens	Proto-oncogene tyrosine-protein kinase ROS	Residual Activity	21.0	%	10.1042/bj20121418
Homo sapiens	Putative heat shock protein HSP 90-beta 2	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	Pyridoxal kinase	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	Quinone reductase 2	Kd	4031.0	nM	10.1126/science.aan4368
Homo sapiens	Rab-like protein 3	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	Ras-related protein Rab-10	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	Ras-related protein Rab-27A	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	Ras-related protein Rab-6A	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	Receptor-interacting serine/threonine-protein kinase 3	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	Receptor protein-tyrosine kinase erbB-4	Residual Activity	19.0	%	10.1042/bj20121418
Homo sapiens	Receptor protein-tyrosine kinase erbB-4	Residual Activity	64.0	%	10.1042/bj20121418
Homo sapiens	Rho-associated protein kinase 1	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	Rho-associated protein kinase 1	Residual Activity	12.0	%	10.1042/bj20121418
Homo sapiens	Rho-associated protein kinase 1	Residual Activity	50.0	%	10.1042/bj20121418
Homo sapiens	Rho-associated protein kinase 2	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	Rho-associated protein kinase 2	Residual Activity	2.0	%	10.1042/bj20121418
Homo sapiens	Rho-associated protein kinase 2	Residual Activity	15.0	%	10.1042/bj20121418
Homo sapiens	Ribosomal protein S6 kinase 1	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	Ribosomal protein S6 kinase 1	Residual Activity	1.0	%	10.1042/bj20121418
Homo sapiens	Ribosomal protein S6 kinase 1	Residual Activity	6.0	%	10.1042/bj20121418
Homo sapiens	Ribosomal protein S6 kinase alpha 1	Kd	2994.0	nM	10.1126/science.aan4368
Homo sapiens	Ribosomal protein S6 kinase alpha 1	Residual Activity	1.0	%	10.1042/bj20121418
Homo sapiens	Ribosomal protein S6 kinase alpha 1	Residual Activity	2.0	%	10.1042/bj20121418
Homo sapiens	Ribosomal protein S6 kinase alpha 2	Residual Activity	0.0	%	10.1042/bj20121418
Homo sapiens	Ribosomal protein S6 kinase alpha 2	Residual Activity	1.0	%	10.1042/bj20121418
Homo sapiens	Ribosomal protein S6 kinase alpha 3	Kd	2990.0	nM	10.1126/science.aan4368
Homo sapiens	Ribosomal protein S6 kinase alpha 3	Residual Activity	1.0	%	10.1042/bj20121418
Homo sapiens	Ribosomal protein S6 kinase alpha 4	Kd	432.0	nM	10.1126/science.aan4368
Homo sapiens	Ribosomal protein S6 kinase alpha 4	Residual Activity	-1.0	%	10.1042/bj20121418
Homo sapiens	Ribosomal protein S6 kinase alpha 4	Residual Activity	0.0	%	10.1042/bj20121418
Homo sapiens	Ribosomal protein S6 kinase alpha 5	Kd	14659.0	nM	10.1126/science.aan4368
Homo sapiens	Ribosomal protein S6 kinase alpha 5	Residual Activity	0.0	%	10.1042/bj20121418
Homo sapiens	Ribosomal protein S6 kinase alpha 5	Residual Activity	5.0	%	10.1042/bj20121418
Homo sapiens	Ribosomal protein S6 kinase alpha 6	Kd	2181.0	nM	10.1126/science.aan4368
Homo sapiens	Ribosomal protein S6 kinase alpha 6	Residual Activity	-2.0	%	10.1042/bj20121418
Homo sapiens	Ribosomal protein S6 kinase alpha 6	Residual Activity	3.0	%	10.1042/bj20121418
Homo sapiens	RNA cytidine acetyltransferase	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	S-adenosylmethionine synthase isoform type-2	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	Septin-9	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	Serine/threonine-protein kinase 10	Kd	481.0	nM	10.1126/science.aan4368
Homo sapiens	Serine/threonine-protein kinase 10	Residual Activity	1.0	%	10.1042/bj20121418
Homo sapiens	Serine/threonine-protein kinase 10	Residual Activity	3.0	%	10.1042/bj20121418
Homo sapiens	Serine/threonine-protein kinase 11	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	Serine/threonine-protein kinase 11	Residual Activity	74.0	%	10.1042/bj20121418
Homo sapiens	Serine/threonine-protein kinase 11	Residual Activity	97.0	%	10.1042/bj20121418
Homo sapiens	Serine/threonine-protein kinase 16	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	Serine/threonine-protein kinase 17A	Residual Activity	0.0	%	10.1042/bj20121418
Homo sapiens	Serine/threonine-protein kinase 17A	Residual Activity	1.0	%	10.1042/bj20121418
Homo sapiens	Serine/threonine-protein kinase 2	Kd	3305.0	nM	10.1126/science.aan4368
Homo sapiens	Serine/threonine-protein kinase 24	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	Serine/threonine-protein kinase 24	Residual Activity	0.0	%	10.1042/bj20121418
Homo sapiens	Serine/threonine-protein kinase 24	Residual Activity	14.0	%	10.1042/bj20121418
Homo sapiens	Serine/threonine-protein kinase 33	Residual Activity	0.0	%	10.1042/bj20121418
Homo sapiens	Serine/threonine-protein kinase 33	Residual Activity	7.0	%	10.1042/bj20121418
Homo sapiens	Serine/threonine-protein kinase 38	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	Serine/threonine-protein kinase 38-like	Kd	2137.0	nM	10.1126/science.aan4368
Homo sapiens	Serine/threonine-protein kinase AKT	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	Serine/threonine-protein kinase AKT	Residual Activity	37.0	%	10.1042/bj20121418
Homo sapiens	Serine/threonine-protein kinase AKT	Residual Activity	101.0	%	10.1042/bj20121418
Homo sapiens	Serine/threonine-protein kinase AKT2	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	Serine/threonine-protein kinase AKT2	Residual Activity	22.0	%	10.1042/bj20121418
Homo sapiens	Serine/threonine-protein kinase AKT2	Residual Activity	67.0	%	10.1042/bj20121418
Homo sapiens	Serine/threonine-protein kinase AKT3	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	Serine/threonine-protein kinase AKT3	Residual Activity	3.0	%	10.1042/bj20121418
Homo sapiens	Serine/threonine-protein kinase AKT3	Residual Activity	11.0	%	10.1042/bj20121418
Homo sapiens	Serine/threonine-protein kinase A-Raf	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	Serine/threonine-protein kinase Aurora-A	Kd	20.0	nM	10.1126/science.aan4368
Homo sapiens	Serine/threonine-protein kinase Aurora-A	Residual Activity	-1.0	%	10.1042/bj20121418
Homo sapiens	Serine/threonine-protein kinase Aurora-A	Residual Activity	2.0	%	10.1042/bj20121418
Homo sapiens	Serine/threonine-protein kinase Aurora-B	Kd	353.0	nM	10.1126/science.aan4368
Homo sapiens	Serine/threonine-protein kinase Aurora-B	Residual Activity	0.0	%	10.1042/bj20121418
Homo sapiens	Serine/threonine-protein kinase Aurora-C	Residual Activity	1.0	%	10.1042/bj20121418
Homo sapiens	Serine/threonine-protein kinase Aurora-C	Residual Activity	2.0	%	10.1042/bj20121418
Homo sapiens	Serine/threonine-protein kinase B-raf	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	Serine/threonine-protein kinase Chk1	Kd	122.0	nM	10.1126/science.aan4368
Homo sapiens	Serine/threonine-protein kinase Chk1	Residual Activity	-1.0	%	10.1042/bj20121418
Homo sapiens	Serine/threonine-protein kinase Chk1	Residual Activity	1.0	%	10.1042/bj20121418
Homo sapiens	Serine/threonine-protein kinase Chk2	Residual Activity	1.0	%	10.1042/bj20121418
Homo sapiens	Serine/threonine-protein kinase Chk2	Residual Activity	3.0	%	10.1042/bj20121418
Homo sapiens	Serine/threonine-protein kinase c-TAK1	Kd	384.0	nM	10.1126/science.aan4368
Homo sapiens	Serine/threonine-protein kinase D2	Kd	30.0	nM	10.1126/science.aan4368
Homo sapiens	Serine/threonine-protein kinase D2	Residual Activity	0.0	%	10.1042/bj20121418
Homo sapiens	Serine/threonine-protein kinase D2	Residual Activity	2.0	%	10.1042/bj20121418
Homo sapiens	Serine/threonine-protein kinase DCLK2	Residual Activity	41.0	%	10.1042/bj20121418
Homo sapiens	Serine/threonine-protein kinase DCLK2	Residual Activity	75.0	%	10.1042/bj20121418
Homo sapiens	Serine/threonine-protein kinase EEF2K	Residual Activity	115.0	%	10.1042/bj20121418
Homo sapiens	Serine/threonine-protein kinase EEF2K	Residual Activity	124.0	%	10.1042/bj20121418
Homo sapiens	Serine/threonine-protein kinase/endoribonuclease IRE1	Kd	19.0	nM	10.1126/science.aan4368
Homo sapiens	Serine/threonine-protein kinase/endoribonuclease IRE2	Kd	908.0	nM	10.1126/science.aan4368
Homo sapiens	Serine/threonine-protein kinase GAK	Kd	1269.0	nM	10.1126/science.aan4368
Homo sapiens	Serine/threonine-protein kinase haspin	Residual Activity	5.0	%	10.1042/bj20121418
Homo sapiens	Serine/threonine-protein kinase haspin	Residual Activity	8.0	%	10.1042/bj20121418
Homo sapiens	Serine/threonine-protein kinase ICK	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	Serine/threonine-protein kinase ILK-1	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	Serine/threonine-protein kinase LATS1	Kd	67.0	nM	10.1126/science.aan4368
Homo sapiens	Serine/threonine-protein kinase LMTK3	IC50	79.43	nM	None
Homo sapiens	Serine/threonine-protein kinase LMTK3	Inhibition	98.91	%	None
Homo sapiens	Serine/threonine-protein kinase MARK1	Residual Activity	0.0	%	10.1042/bj20121418
Homo sapiens	Serine/threonine-protein kinase MRCK-A	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	Serine/threonine-protein kinase MRCK-A	Residual Activity	23.0	%	10.1042/bj20121418
Homo sapiens	Serine/threonine-protein kinase MRCK-A	Residual Activity	71.0	%	10.1042/bj20121418
Homo sapiens	Serine/threonine-protein kinase MRCK beta	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	Serine/threonine-protein kinase MRCK beta	Residual Activity	5.0	%	10.1042/bj20121418
Homo sapiens	Serine/threonine-protein kinase MRCK beta	Residual Activity	33.0	%	10.1042/bj20121418
Homo sapiens	Serine/threonine-protein kinase MRCK gamma	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	Serine/threonine-protein kinase MST1	Kd	29.0	nM	10.1126/science.aan4368
Homo sapiens	Serine/threonine-protein kinase MST1	Residual Activity	1.0	%	10.1042/bj20121418
Homo sapiens	Serine/threonine-protein kinase MST1	Residual Activity	5.0	%	10.1042/bj20121418
Homo sapiens	Serine/threonine-protein kinase MST2	Kd	43.0	nM	10.1126/science.aan4368
Homo sapiens	Serine/threonine-protein kinase MST2	Residual Activity	1.0	%	10.1042/bj20121418
Homo sapiens	Serine/threonine-protein kinase MST2	Residual Activity	2.0	%	10.1042/bj20121418
Homo sapiens	Serine/threonine-protein kinase MST4	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	Serine/threonine-protein kinase mTOR	Residual Activity	70.0	%	10.1042/bj20121418
Homo sapiens	Serine/threonine-protein kinase mTOR	Residual Activity	79.0	%	10.1042/bj20121418
Homo sapiens	Serine/threonine-protein kinase mTOR	Residual Activity	89.0	%	10.1042/bj20121418
Homo sapiens	Serine/threonine-protein kinase mTOR	Residual Activity	90.0	%	10.1042/bj20121418
Homo sapiens	Serine/threonine-protein kinase N3	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	Serine/threonine-protein kinase Nek1	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	Serine/threonine-protein kinase Nek11	Residual Activity	9.0	%	10.1042/bj20121418
Homo sapiens	Serine/threonine-protein kinase Nek11	Residual Activity	34.0	%	10.1042/bj20121418
Homo sapiens	Serine/threonine-protein kinase NEK2	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	Serine/threonine-protein kinase NEK2	Residual Activity	29.0	%	10.1042/bj20121418
Homo sapiens	Serine/threonine-protein kinase NEK2	Residual Activity	75.0	%	10.1042/bj20121418
Homo sapiens	Serine/threonine-protein kinase Nek3	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	Serine/threonine-protein kinase Nek3	Residual Activity	53.0	%	10.1042/bj20121418
Homo sapiens	Serine/threonine-protein kinase Nek3	Residual Activity	65.0	%	10.1042/bj20121418
Homo sapiens	Serine/threonine-protein kinase NEK6	Residual Activity	104.0	%	10.1042/bj20121418
Homo sapiens	Serine/threonine-protein kinase NEK6	Residual Activity	120.0	%	10.1042/bj20121418
Homo sapiens	Serine/threonine-protein kinase NEK7	Kd	3.0	nM	10.1126/science.aan4368
Homo sapiens	Serine/threonine-protein kinase NEK7	Residual Activity	95.0	%	10.1042/bj20121418
Homo sapiens	Serine/threonine-protein kinase NEK7	Residual Activity	103.0	%	10.1042/bj20121418
Homo sapiens	Serine/threonine-protein kinase NEK9	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	Serine/threonine protein kinase NLK	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	Serine/threonine protein kinase NLK	Residual Activity	10.0	%	10.1042/bj20121418
Homo sapiens	Serine/threonine protein kinase NLK	Residual Activity	42.0	%	10.1042/bj20121418
Homo sapiens	Serine/threonine-protein kinase PAK 2	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	Serine/threonine-protein kinase PAK 2	Residual Activity	2.0	%	10.1042/bj20121418
Homo sapiens	Serine/threonine-protein kinase PAK 2	Residual Activity	19.0	%	10.1042/bj20121418
Homo sapiens	Serine/threonine-protein kinase PAK 3	Residual Activity	3.0	%	10.1042/bj20121418
Homo sapiens	Serine/threonine-protein kinase PAK 3	Residual Activity	4.0	%	10.1042/bj20121418
Homo sapiens	Serine/threonine-protein kinase PAK 4	Kd	344.0	nM	10.1126/science.aan4368
Homo sapiens	Serine/threonine-protein kinase PAK 4	Residual Activity	0.0	%	10.1042/bj20121418
Homo sapiens	Serine/threonine-protein kinase PAK 4	Residual Activity	3.0	%	10.1042/bj20121418
Homo sapiens	Serine/threonine-protein kinase PAK6	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	Serine/threonine-protein kinase PAK6	Residual Activity	-1.0	%	10.1042/bj20121418
Homo sapiens	Serine/threonine-protein kinase PAK6	Residual Activity	0.0	%	10.1042/bj20121418
Homo sapiens	Serine/threonine-protein kinase PAK7	Residual Activity	1.0	%	10.1042/bj20121418
Homo sapiens	Serine/threonine-protein kinase PAK7	Residual Activity	6.0	%	10.1042/bj20121418
Homo sapiens	Serine/threonine-protein kinase PCTAIRE-1	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	Serine/threonine-protein kinase PCTAIRE-2	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	Serine/threonine-protein kinase PIM1	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	Serine/threonine-protein kinase PIM1	Residual Activity	1.0	%	10.1042/bj20121418
Homo sapiens	Serine/threonine-protein kinase PIM1	Residual Activity	10.0	%	10.1042/bj20121418
Homo sapiens	Serine/threonine-protein kinase PIM2	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	Serine/threonine-protein kinase PIM2	Residual Activity	-2.0	%	10.1042/bj20121418
Homo sapiens	Serine/threonine-protein kinase PIM2	Residual Activity	2.0	%	10.1042/bj20121418
Homo sapiens	Serine/threonine-protein kinase PIM3	Residual Activity	5.0	%	10.1042/bj20121418
Homo sapiens	Serine/threonine-protein kinase PIM3	Residual Activity	31.0	%	10.1042/bj20121418
Homo sapiens	Serine/threonine-protein kinase PLK1	Residual Activity	17.0	%	10.1042/bj20121418
Homo sapiens	Serine/threonine-protein kinase PLK1	Residual Activity	50.0	%	10.1042/bj20121418
Homo sapiens	Serine/threonine-protein kinase PLK2	Residual Activity	36.0	%	10.1042/bj20121418
Homo sapiens	Serine/threonine-protein kinase PLK2	Residual Activity	72.0	%	10.1042/bj20121418
Homo sapiens	Serine/threonine-protein kinase PLK3	Residual Activity	54.0	%	10.1042/bj20121418
Homo sapiens	Serine/threonine-protein kinase PLK3	Residual Activity	90.0	%	10.1042/bj20121418
Homo sapiens	Serine/threonine-protein kinase PLK4	Kd	73.0	nM	10.1126/science.aan4368
Homo sapiens	Serine/threonine-protein kinase PRKX	Residual Activity	0.0	%	10.1042/bj20121418
Homo sapiens	Serine/threonine-protein kinase PRKX	Residual Activity	2.0	%	10.1042/bj20121418
Homo sapiens	Serine/threonine-protein kinase RAF	Residual Activity	69.0	%	10.1042/bj20121418
Homo sapiens	Serine/threonine-protein kinase RAF	Residual Activity	78.0	%	10.1042/bj20121418
Homo sapiens	Serine/threonine-protein kinase RIPK2	Kd	526.0	nM	10.1126/science.aan4368
Homo sapiens	Serine/threonine-protein kinase RIPK2	Residual Activity	3.0	%	10.1042/bj20121418
Homo sapiens	Serine/threonine-protein kinase RIPK2	Residual Activity	5.0	%	10.1042/bj20121418
Homo sapiens	Serine/threonine-protein kinase Sgk1	Residual Activity	1.0	%	10.1042/bj20121418
Homo sapiens	Serine/threonine-protein kinase Sgk1	Residual Activity	4.0	%	10.1042/bj20121418
Homo sapiens	Serine/threonine-protein kinase Sgk2	Residual Activity	1.0	%	10.1042/bj20121418
Homo sapiens	Serine/threonine-protein kinase Sgk2	Residual Activity	7.0	%	10.1042/bj20121418
Homo sapiens	Serine/threonine-protein kinase Sgk3	Residual Activity	13.0	%	10.1042/bj20121418
Homo sapiens	Serine/threonine-protein kinase Sgk3	Residual Activity	47.0	%	10.1042/bj20121418
Homo sapiens	Serine/threonine-protein kinase SIK1	Residual Activity	0.0	%	10.1042/bj20121418
Homo sapiens	Serine/threonine-protein kinase SIK2	Kd	58.0	nM	10.1126/science.aan4368
Homo sapiens	Serine/threonine-protein kinase SIK3	Kd	4027.0	nM	10.1126/science.aan4368
Homo sapiens	Serine/threonine-protein kinase SRPK1	Residual Activity	14.0	%	10.1042/bj20121418
Homo sapiens	Serine/threonine-protein kinase SRPK1	Residual Activity	67.0	%	10.1042/bj20121418
Homo sapiens	Serine/threonine-protein kinase SRPK2	Residual Activity	52.0	%	10.1042/bj20121418
Homo sapiens	Serine/threonine-protein kinase SRPK2	Residual Activity	97.0	%	10.1042/bj20121418
Homo sapiens	Serine/threonine-protein kinase SRPK3	Residual Activity	2.0	%	10.1042/bj20121418
Homo sapiens	Serine/threonine-protein kinase SRPK3	Residual Activity	11.0	%	10.1042/bj20121418
Homo sapiens	Serine/threonine-protein kinase TAO1	Kd	18757.0	nM	10.1126/science.aan4368
Homo sapiens	Serine/threonine-protein kinase TAO1	Residual Activity	3.0	%	10.1042/bj20121418
Homo sapiens	Serine/threonine-protein kinase TAO1	Residual Activity	5.0	%	10.1042/bj20121418
Homo sapiens	Serine/threonine-protein kinase TAO2	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	Serine/threonine-protein kinase TAO2	Residual Activity	2.0	%	10.1042/bj20121418
Homo sapiens	Serine/threonine-protein kinase TAO2	Residual Activity	16.0	%	10.1042/bj20121418
Homo sapiens	Serine/threonine-protein kinase TAO3	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	Serine/threonine-protein kinase TAO3	Residual Activity	3.0	%	10.1042/bj20121418
Homo sapiens	Serine/threonine-protein kinase TAO3	Residual Activity	10.0	%	10.1042/bj20121418
Homo sapiens	Serine/threonine-protein kinase TBK1	Kd	1157.0	nM	10.1126/science.aan4368
Homo sapiens	Serine/threonine-protein kinase TBK1	Residual Activity	-1.0	%	10.1042/bj20121418
Homo sapiens	Serine/threonine-protein kinase TBK1	Residual Activity	3.0	%	10.1042/bj20121418
Homo sapiens	Serine/threonine-protein kinase tousled-like 2	Residual Activity	0.0	%	10.1042/bj20121418
Homo sapiens	Serine/threonine-protein kinase tousled-like 2	Residual Activity	1.0	%	10.1042/bj20121418
Homo sapiens	Serine/threonine-protein kinase ULK1	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	Serine/threonine-protein kinase ULK2	Residual Activity	0.0	%	10.1042/bj20121418
Homo sapiens	Serine/threonine-protein kinase ULK2	Residual Activity	7.0	%	10.1042/bj20121418
Homo sapiens	Serine/threonine-protein kinase ULK3	Kd	107.0	nM	10.1126/science.aan4368
Homo sapiens	Serine/threonine-protein kinase ULK3	Residual Activity	0.0	%	10.1042/bj20121418
Homo sapiens	Serine/threonine-protein kinase ULK3	Residual Activity	1.0	%	10.1042/bj20121418
Homo sapiens	Serine/threonine-protein kinase VRK2	Residual Activity	100.0	%	10.1042/bj20121418
Homo sapiens	Serine/threonine-protein kinase VRK2	Residual Activity	101.0	%	10.1042/bj20121418
Homo sapiens	Serine/threonine-protein kinase WEE1	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	Serine/threonine-protein kinase WNK2	Residual Activity	12.0	%	10.1042/bj20121418
Homo sapiens	Serine/threonine-protein kinase WNK2	Residual Activity	63.0	%	10.1042/bj20121418
Homo sapiens	Serine/threonine-protein kinase WNK3	Residual Activity	8.0	%	10.1042/bj20121418
Homo sapiens	Serine/threonine-protein kinase WNK3	Residual Activity	70.0	%	10.1042/bj20121418
Homo sapiens	STE20-related kinase adapter protein alpha	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	Stem cell growth factor receptor	Residual Activity	20.0	%	10.1042/bj20121418
Homo sapiens	Stem cell growth factor receptor	Residual Activity	76.0	%	10.1042/bj20121418
Homo sapiens	Structural maintenance of chromosomes protein 1A	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	Structural maintenance of chromosomes protein 2	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	Testis-specific serine/threonine-protein kinase 1	Residual Activity	-1.0	%	10.1042/bj20121418
Homo sapiens	Testis-specific serine/threonine-protein kinase 1	Residual Activity	0.0	%	10.1042/bj20121418
Homo sapiens	Testis-specific serine/threonine-protein kinase 2	Residual Activity	0.0	%	10.1042/bj20121418
Homo sapiens	Testis-specific serine/threonine-protein kinase 2	Residual Activity	8.0	%	10.1042/bj20121418
Homo sapiens	TGF-beta receptor type I	Kd	2179.0	nM	10.1126/science.aan4368
Homo sapiens	TGF-beta receptor type I	Residual Activity	8.0	%	10.1042/bj20121418
Homo sapiens	TGF-beta receptor type I	Residual Activity	49.0	%	10.1042/bj20121418
Homo sapiens	TGF-beta receptor type II	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	Thyroid hormone receptor-associated protein 3	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	TP53-regulating kinase	Kd	3840.0	nM	10.1126/science.aan4368
Homo sapiens	TRAF2- and NCK-interacting kinase	Kd	10.0	nM	10.1126/science.aan4368
Homo sapiens	Tyrosine- and threonine-specific cdc2-inhibitory kinase	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	Tyrosine kinase non-receptor protein 2	Kd	1717.0	nM	10.1126/science.aan4368
Homo sapiens	Tyrosine kinase non-receptor protein 2	Residual Activity	0.0	%	10.1042/bj20121418
Homo sapiens	Tyrosine-protein kinase ABL	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	Tyrosine-protein kinase ABL	Residual Activity	51.0	%	10.1042/bj20121418
Homo sapiens	Tyrosine-protein kinase ABL	Residual Activity	80.0	%	10.1042/bj20121418
Homo sapiens	Tyrosine-protein kinase ABL2	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	Tyrosine-protein kinase ABL2	Residual Activity	35.0	%	10.1042/bj20121418
Homo sapiens	Tyrosine-protein kinase ABL2	Residual Activity	79.0	%	10.1042/bj20121418
Homo sapiens	Tyrosine-protein kinase BLK	Residual Activity	0.0	%	10.1042/bj20121418
Homo sapiens	Tyrosine-protein kinase BLK	Residual Activity	1.0	%	10.1042/bj20121418
Homo sapiens	Tyrosine-protein kinase BMX	Residual Activity	1.0	%	10.1042/bj20121418
Homo sapiens	Tyrosine-protein kinase BMX	Residual Activity	2.0	%	10.1042/bj20121418
Homo sapiens	Tyrosine-protein kinase BRK	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	Tyrosine-protein kinase BRK	Residual Activity	1.0	%	10.1042/bj20121418
Homo sapiens	Tyrosine-protein kinase BRK	Residual Activity	19.0	%	10.1042/bj20121418
Homo sapiens	Tyrosine-protein kinase BTK	Kd	1567.0	nM	10.1126/science.aan4368
Homo sapiens	Tyrosine-protein kinase BTK	Residual Activity	-1.0	%	10.1042/bj20121418
Homo sapiens	Tyrosine-protein kinase CSK	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	Tyrosine-protein kinase CSK	Residual Activity	18.0	%	10.1042/bj20121418
Homo sapiens	Tyrosine-protein kinase CSK	Residual Activity	71.0	%	10.1042/bj20121418
Homo sapiens	Tyrosine-protein kinase FER	Kd	455.0	nM	10.1126/science.aan4368
Homo sapiens	Tyrosine-protein kinase FER	Residual Activity	0.0	%	10.1042/bj20121418
Homo sapiens	Tyrosine-protein kinase FER	Residual Activity	2.0	%	10.1042/bj20121418
Homo sapiens	Tyrosine-protein kinase FES	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	Tyrosine-protein kinase FES	Residual Activity	1.0	%	10.1042/bj20121418
Homo sapiens	Tyrosine-protein kinase FES	Residual Activity	7.0	%	10.1042/bj20121418
Homo sapiens	Tyrosine-protein kinase FGR	Residual Activity	-1.0	%	10.1042/bj20121418
Homo sapiens	Tyrosine-protein kinase FGR	Residual Activity	3.0	%	10.1042/bj20121418
Homo sapiens	Tyrosine-protein kinase FRK	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	Tyrosine-protein kinase FRK	Residual Activity	6.0	%	10.1042/bj20121418
Homo sapiens	Tyrosine-protein kinase FRK	Residual Activity	25.0	%	10.1042/bj20121418
Homo sapiens	Tyrosine-protein kinase FYN	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	Tyrosine-protein kinase FYN	Residual Activity	0.0	%	10.1042/bj20121418
Homo sapiens	Tyrosine-protein kinase FYN	Residual Activity	4.0	%	10.1042/bj20121418
Homo sapiens	Tyrosine-protein kinase HCK	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	Tyrosine-protein kinase HCK	Residual Activity	1.0	%	10.1042/bj20121418
Homo sapiens	Tyrosine-protein kinase HCK	Residual Activity	3.0	%	10.1042/bj20121418
Homo sapiens	Tyrosine-protein kinase HCK	Residual Activity	4.0	%	10.1042/bj20121418
Homo sapiens	Tyrosine-protein kinase ITK/TSK	Residual Activity	1.0	%	10.1042/bj20121418
Homo sapiens	Tyrosine-protein kinase ITK/TSK	Residual Activity	15.0	%	10.1042/bj20121418
Homo sapiens	Tyrosine-protein kinase JAK1	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	Tyrosine-protein kinase JAK2	Residual Activity	-1.0	%	10.1042/bj20121418
Homo sapiens	Tyrosine-protein kinase JAK2	Residual Activity	2.0	%	10.1042/bj20121418
Homo sapiens	Tyrosine-protein kinase JAK3	Residual Activity	0.0	%	10.1042/bj20121418
Homo sapiens	Tyrosine-protein kinase LCK	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	Tyrosine-protein kinase LCK	Residual Activity	2.0	%	10.1042/bj20121418
Homo sapiens	Tyrosine-protein kinase LCK	Residual Activity	6.0	%	10.1042/bj20121418
Homo sapiens	Tyrosine-protein kinase LCK	Residual Activity	8.0	%	10.1042/bj20121418
Homo sapiens	Tyrosine-protein kinase LCK	Residual Activity	9.0	%	10.1042/bj20121418
Homo sapiens	Tyrosine-protein kinase Lyn	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	Tyrosine-protein kinase Lyn	Residual Activity	0.0	%	10.1042/bj20121418
Homo sapiens	Tyrosine-protein kinase Lyn	Residual Activity	3.0	%	10.1042/bj20121418
Homo sapiens	Tyrosine-protein kinase receptor FLT3	Kd	227.0	nM	10.1126/science.aan4368
Homo sapiens	Tyrosine-protein kinase receptor FLT3	Residual Activity	0.0	%	10.1042/bj20121418
Homo sapiens	Tyrosine-protein kinase receptor FLT3	Residual Activity	1.0	%	10.1042/bj20121418
Homo sapiens	Tyrosine-protein kinase receptor RET	Kd	669.0	nM	10.1126/science.aan4368
Homo sapiens	Tyrosine-protein kinase receptor RET	Residual Activity	1.0	%	10.1042/bj20121418
Homo sapiens	Tyrosine-protein kinase receptor RET	Residual Activity	2.0	%	10.1042/bj20121418
Homo sapiens	Tyrosine-protein kinase receptor TYRO3	Residual Activity	2.0	%	10.1042/bj20121418
Homo sapiens	Tyrosine-protein kinase receptor TYRO3	Residual Activity	6.0	%	10.1042/bj20121418
Homo sapiens	Tyrosine-protein kinase receptor UFO	Residual Activity	-3.0	%	10.1042/bj20121418
Homo sapiens	Tyrosine-protein kinase receptor UFO	Residual Activity	4.0	%	10.1042/bj20121418
Homo sapiens	Tyrosine-protein kinase SRC	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	Tyrosine-protein kinase SRC	Residual Activity	5.0	%	10.1042/bj20121418
Homo sapiens	Tyrosine-protein kinase SRC	Residual Activity	35.0	%	10.1042/bj20121418
Homo sapiens	Tyrosine-protein kinase SYK	Kd	545.0	nM	10.1126/science.aan4368
Homo sapiens	Tyrosine-protein kinase SYK	Residual Activity	1.0	%	10.1042/bj20121418
Homo sapiens	Tyrosine-protein kinase SYK	Residual Activity	2.0	%	10.1042/bj20121418
Homo sapiens	Tyrosine-protein kinase TEC	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	Tyrosine-protein kinase TEC	Residual Activity	2.0	%	10.1042/bj20121418
Homo sapiens	Tyrosine-protein kinase TEC	Residual Activity	3.0	%	10.1042/bj20121418
Homo sapiens	Tyrosine-protein kinase TIE-2	Residual Activity	3.0	%	10.1042/bj20121418
Homo sapiens	Tyrosine-protein kinase TIE-2	Residual Activity	20.0	%	10.1042/bj20121418
Homo sapiens	Tyrosine-protein kinase TXK	Residual Activity	5.0	%	10.1042/bj20121418
Homo sapiens	Tyrosine-protein kinase TXK	Residual Activity	35.0	%	10.1042/bj20121418
Homo sapiens	Tyrosine-protein kinase TYK2	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	Tyrosine-protein kinase YES	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	Tyrosine-protein kinase YES	Residual Activity	1.0	%	10.1042/bj20121418
Homo sapiens	Tyrosine-protein kinase YES	Residual Activity	11.0	%	10.1042/bj20121418
Homo sapiens	Tyrosine-protein kinase ZAP-70	Residual Activity	2.0	%	10.1042/bj20121418
Homo sapiens	Tyrosine-protein kinase ZAP-70	Residual Activity	16.0	%	10.1042/bj20121418
Homo sapiens	Tyrosyl-tRNA synthetase	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	U5 small nuclear ribonucleoprotein 200 kDa helicase	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	Uncharacterized aarF domain-containing protein kinase 1	Kd	6090.0	nM	10.1126/science.aan4368
Homo sapiens	Uncharacterized aarF domain-containing protein kinase 5	Kd	30000.0	nM	10.1126/science.aan4368
Homo sapiens	Uncharacterized protein FLJ45252	Kd	21.0	nM	10.1126/science.aan4368
Homo sapiens	Vascular endothelial growth factor receptor 1	Residual Activity	0.0	%	10.1042/bj20121418
Homo sapiens	Vascular endothelial growth factor receptor 2	IC50	43.0	nM	10.1016/s0960-894x(02)00638-8
Homo sapiens	Vascular endothelial growth factor receptor 2	IC50	43.0	nM	10.1021/jm040178m
Homo sapiens	Vascular endothelial growth factor receptor 2	Residual Activity	0.0	%	10.1042/bj20121418
Homo sapiens	Vascular endothelial growth factor receptor 2	Residual Activity	3.0	%	10.1042/bj20121418
Homo sapiens	Vascular endothelial growth factor receptor 3	Residual Activity	0.0	%	10.1042/bj20121418
Homo sapiens	Vascular endothelial growth factor receptor 3	Residual Activity	1.0	%	10.1042/bj20121418
Homo sapiens	Very long-chain specific acyl-CoA dehydrogenase, mitochondrial	Kd	30000.0	nM	10.1126/science.aan4368
Oryctolagus cuniculus	cAMP-dependent protein kinase alpha-catalytic subunit	IC50	0.016	nM	10.1021/jm970031d
Rattus norvegicus	Choline acetylase	Control	120.0	%	10.1021/jm970031d
Rattus norvegicus	Choline acetylase	Control	148.0	%	10.1021/jm970031d
Rattus norvegicus	Choline acetylase	Control	186.0	%	10.1021/jm970031d
Rattus norvegicus	Choline acetylase	Control	325.0	%	10.1021/jm970031d
Rattus norvegicus	Protein kinase C gamma	IC50	470.0	nM	10.1021/jm00079a024
Rattus norvegicus	Protein kinase C (PKC)	IC50	0.028	nM	10.1021/jm970031d
Rattus norvegicus	Protein kinase C (PKC)	IC50	60.0	nM	10.1016/S0960-894X(00)80013-X
Rattus norvegicus	Protein kinase C (PKC)	IC50	60.0	nM	10.1016/S0960-894X(01)80356-5
Rattus norvegicus	Protein kinase C (PKC)	IC50	250.0	nM	10.1021/jm9702037
None	Unchecked	IC50	1.8	nM	10.1021/acs.jmedchem.8b00294
None	Unchecked	IC50	250.0	nM	10.1021/jm040178m
None	Unchecked	IC50	270.0	nM	10.1021/jm00079a024
None	Unchecked	Kd	38.0	nM	10.1126/science.aan4368
None	Unchecked	Kd	2436.0	nM	10.1126/science.aan4368
None	Unchecked	Kd	30000.0	nM	10.1126/science.aan4368
None	Unchecked	Ratio	19.0	None	10.1021/jm040178m