Terramycin
AlkaPlorer ID: AK022105
Synonym: None
IUPAC Name: (4S,4aR,5S,5aR,6S,12aR)-4-(dimethylamino)-1,5,6,10,11,12a-hexahydroxy-6-methyl-3,12-dioxo-4,4a,5,5a-tetrahydrotetracene-2-carboxamide
Structure
SMILES: CN(C)[C@@H]1C(=O)C(C(N)=O)=C(O)[C@@]2(O)C(=O)C3=C(O)C4=C(O)C=CC=C4[C@@](C)(O)[C@H]3[C@H](O)[C@@H]12
InChI: InChI=1S/C22H24N2O9/c1-21(32)7-5-4-6-8(25)9(7)15(26)10-12(21)17(28)13-14(24(2)3)16(27)11(20(23)31)19(30)22(13,33)18(10)29/h4-6,12-14,17,25-26,28,30,32-33H,1-3H3,(H2,23,31)/t12-,13-,14+,17+,21-,22+/m1/s1
InChIKey: OWFJMIVZYSDULZ-PXOLEDIWSA-N
Source
| Species | Genus | Family | Order | Class | Phylum | Kingdom | Domain |
|---|---|---|---|---|---|---|---|
| Sparticola junci | Sparticola | Sporormiaceae | Pleosporales | Dothideomycetes | Ascomycota | Fungi | Eukaryota |
Properties Information
Molecule Weight: 460.43900000000014
TPSA？: 201.85
MolLogP？: -1.4001999999999974
Number of H-Donors: 7
Number of H-Acceptors: 10
RingCount: 4
Activities Information
| Organism | Target Name | Standard Type | Standard Value | Standard Units | doi |
|---|---|---|---|---|---|
| Bacillus subtilis | Bacillus subtilis | MIC | 3.33 | ug.mL-1 | 10.1021/acs.jnatprod.1c00975 |
| Chromobacterium violaceum | Chromobacterium violaceum | MIC | 1.7 | ug.mL-1 | 10.1021/acs.jnatprod.1c00975 |
| Escherichia coli | Escherichia coli | MIC | 8.3 | ug.mL-1 | 10.1021/acs.jnatprod.1c00975 |
| Micrococcus luteus | Micrococcus luteus | MIC | 0.83 | ug.mL-1 | 10.1021/acs.jnatprod.1c00975 |
| Micrococcus luteus | Micrococcus luteus | MIC | 8.3 | ug.mL-1 | 10.1021/acs.jnatprod.7b00764 |
| Staphylococcus aureus | Staphylococcus aureus | MIC | 0.4 | ug.mL-1 | 10.1021/acs.jnatprod.1c00975 |
| Staphylococcus aureus | Staphylococcus aureus | MIC | 1.0 | ug.mL-1 | 10.1021/acs.jnatprod.7b00764 |