Pyridomycin
AlkaPlorer ID: AK022317
Synonym: None
IUPAC Name: N-[(2Z,5R,6S,9S,10R,11R)-2-butan-2-ylidene-10-hydroxy-5,11-dimethyl-3,7,12-trioxo-9-(pyridin-3-ylmethyl)-1,4-dioxa-8-azacyclododec-6-yl]-3-hydroxypyridine-2-carboxamide
Structure
SMILES: CC/C(C)=C1\OC(=O)[C@H](C)[C@@H](O)[C@H](CC2=CC=CN=C2)N=C(O)[C@@H](N=C(O)C2=NC=CC=C2O)[C@@H](C)OC1=O
InChI: InChI=1S/C27H32N4O8/c1-5-14(2)23-27(37)38-16(4)20(31-25(35)21-19(32)9-7-11-29-21)24(34)30-18(12-17-8-6-10-28-13-17)22(33)15(3)26(36)39-23/h6-11,13,15-16,18,20,22,32-33H,5,12H2,1-4H3,(H,30,34)(H,31,35)/b23-14-/t15-,16-,18+,20+,22-/m1/s1
InChIKey: WHIKSLGSXKIHCA-QJJXMMRLSA-N
Source
| Species | Genus | Family | Order | Class | Phylum | Kingdom | Domain |
|---|---|---|---|---|---|---|---|
| Streptomyces pyridomyceticus | Streptomyces | Streptomycetaceae | Kitasatosporales | Actinomycetes | Actinomycetota | None | Bacteria |
Properties Information
Molecule Weight: 540.5730000000001
TPSA？: 184.02
MolLogP？: 2.5927000000000007
Number of H-Donors: 4
Number of H-Acceptors: 10
RingCount: 3
Activities Information
| Organism | Target Name | Standard Type | Standard Value | Standard Units | doi |
|---|---|---|---|---|---|
| Mycobacterium tuberculosis | Serine/threonine-protein kinase pknB | Inhibition | None | % | 10.1016/j.bmc.2018.04.045 |