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N-Phenyl-1-naphthylamine 

AlkaPlorer ID: AK022564

Synonym: 1-Anilinonaphthalene, Antioxidant PAN, Neozone A, Nocrac PA, Nonox A, Nonox AN, Vulkanox PAN

IUPAC Name: N-phenylnaphthalen-1-amine

Structure

SMILES: C1=CC=C(NC2=CC=CC3=C2C=CC=C3)C=C1

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InChI: InChI=1S/C16H13N/c1-2-9-14(10-3-1)17-16-12-6-8-13-7-4-5-11-15(13)16/h1-12,17H

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InChIKey: XQVWYOYUZDUNRW-UHFFFAOYSA-N

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Properties Information

Molecule Weight: 219.287

TPSA？: 12.03

MolLogP？: 4.583400000000003

Number of H-Donors: 1

Number of H-Acceptors: 1

RingCount: 3

Activities Information

Organism Target Name Standard Type Standard Value Standard Units doi
Bacillus anthracis Anthrax lethal factor Potency 25118.9 nM None
Homo sapiens 15-hydroxyprostaglandin dehydrogenase [NAD+] Potency 10000.0 nM None
Homo sapiens Aldehyde dehydrogenase 1A1 Potency 31622.8 nM None
Homo sapiens Androgen Receptor Potency 19952.6 nM None
Homo sapiens Androgen Receptor Potency 28183.8 nM None
Homo sapiens Androgen Receptor Potency 31622.8 nM None
Homo sapiens Arachidonate 15-lipoxygenase Potency 31622.8 nM None
Homo sapiens Aryl hydrocarbon receptor Potency 44668.4 nM None
Homo sapiens ATPase family AAA domain-containing protein 5 Potency 16353.5 nM None
Homo sapiens Cellular tumor antigen p53 Potency 3.2 nM None
Homo sapiens Cytochrome P450 3A4 Potency 31622.8 nM None
Homo sapiens DNA dC->dU-editing enzyme APOBEC-3F Potency 19952.6 nM None
Homo sapiens DNA dC->dU-editing enzyme APOBEC-3G Potency 15848.9 nM None
Homo sapiens Dual specificity phosphatase Cdc25B Inhibition nan % 10.1021/acs.jmedchem.9b00632
Homo sapiens Dual specificity phosphatase Cdc25B Ki 32000.0 nM 10.1021/acs.jmedchem.9b00632
Homo sapiens Endoplasmic reticulum-associated amyloid beta-peptide-binding protein Potency 31622.8 nM None
Homo sapiens Estrogen receptor alpha Potency 10000.0 nM None
Homo sapiens Estrogen receptor alpha Potency 22387.2 nM None
Homo sapiens Estrogen receptor alpha Potency 28183.8 nM None
Homo sapiens Geminin Potency 20596.2 nM None
Homo sapiens Glucagon-like peptide 1 receptor Potency 10000.0 nM None
Homo sapiens Glucocorticoid receptor Potency 2.5 nM None
Homo sapiens Glucocorticoid receptor Potency 44668.4 nM None
Homo sapiens HepG2 Potency 35481.3 nM None
Homo sapiens HERG Potency 28183.8 nM None
Homo sapiens Interleukin-8 Potency 74978.0 nM None
Homo sapiens Nuclear factor erythroid 2-related factor 2 Potency 16785.5 nM None
Homo sapiens Nuclear factor erythroid 2-related factor 2 Potency 24336.5 nM None
Homo sapiens Nuclear factor erythroid 2-related factor 2 Potency 42163.2 nM None
Homo sapiens Nuclear factor NF-kappa-B p105 subunit Potency 50118.7 nM None
Homo sapiens Peroxisome proliferator-activated receptor alpha Potency 50118.7 nM None
Homo sapiens Peroxisome proliferator-activated receptor gamma Potency 39810.7 nM None
Homo sapiens Peroxisome proliferator-activated receptor gamma Potency 44668.4 nM None
Homo sapiens Rap guanine nucleotide exchange factor 4 Potency 39810.7 nM None
Homo sapiens Serine-protein kinase ATM Potency 35481.3 nM None
Homo sapiens Sphingomyelin phosphodiesterase Potency 25118.9 nM None
Homo sapiens Thyroid stimulating hormone receptor Potency 63095.7 nM None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 25929.0 nM None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 29092.9 nM None
Homo sapiens Vitamin D receptor Potency 28183.8 nM None
Homo sapiens Vitamin D receptor Potency 39810.7 nM None
Rattus norvegicus Nuclear receptor subfamily 1 group I member 2 Potency 70794.6 nM None
Rattus norvegicus Thioredoxin reductase 1, cytoplasmic Potency 25118.9 nM None
Trypanosoma cruzi Cruzipain Potency 39810.7 nM None
None Molecular identity unknown Potency 44668.4 nM None
None Molecular identity unknown Potency 70794.6 nM None
None Molecular identity unknown Potency 74978.0 nM None
None Unchecked Fold_reduction 2.3 None 10.1016/j.bmcl.2003.12.015
None Unchecked Kd 32.0 nM 10.1021/jm500325k
None Unchecked Potency 25929.0 nM None
None Unchecked Potency 31622.8 nM None

Metabolism Information