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name Structure Reference Source Properties Activities Metabolism

(+)-Murrayazoline

AlkaPlorer ID: AK022653

Synonym: 'Murrayazoline', 'Curryangin', 'Mahanimbidine', 'Curryangine', 'Mahanimbidin'

IUPAC Name: (14R,17S,19S)-3,13,13,17-tetramethyl-21-oxa-12-azahexacyclo[10.7.1.12,17.05,20.06,11.014,19]henicosa-1,3,5(20),6,8,10-hexaene

Structure

SMILES: CC1=C2O[C@@]3(C)CC[C@@H]4[C@H](C3)C2=C2C(=C1)C1=CC=CC=C1N2C4(C)C

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InChI: InChI=1S/C23H25NO/c1-13-11-15-14-7-5-6-8-18(14)24-20(15)19-16-12-23(4,25-21(13)19)10-9-17(16)22(24,2)3/h5-8,11,16-17H,9-10,12H2,1-4H3/t16-,17+,23-/m0/s1

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InChIKey: YPSWCORASQDCJM-MFEFFIJZSA-N

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Source

Species Genus Family Order Class Phylum Kingdom Domain
Murraya koenigii Murraya Rutaceae Sapindales Magnoliopsida Streptophyta Viridiplantae Eukaryota

Properties Information

Molecule Weight: 331.4590000000001

TPSA？: 14.16

MolLogP？: 5.8864200000000055

Number of H-Donors: 0

Number of H-Acceptors: 2

RingCount: 6

Activities Information

Organism Target Name Standard Type Standard Value Standard Units doi
Homo sapiens 786-0 LC50 25118.86 nM 10.1021/np000020e
Homo sapiens A498 LC50 25118.86 nM 10.1021/np000020e
Homo sapiens A549 LC50 25118.86 nM 10.1021/np000020e
Homo sapiens ACHN LC50 25118.86 nM 10.1021/np000020e
Homo sapiens BT-549 LC50 25118.86 nM 10.1021/np000020e
Homo sapiens CAKI-1 LC50 25118.86 nM 10.1021/np000020e
Homo sapiens CCRF-CEM LC50 25118.86 nM 10.1021/np000020e
Homo sapiens COLO 205 LC50 25118.86 nM 10.1021/np000020e
Homo sapiens DLD-1 LC50 25118.86 nM 10.1021/np000020e
Homo sapiens DMS-273 LC50 25118.86 nM 10.1021/np000020e
Homo sapiens DU-145 LC50 25118.86 nM 10.1021/np000020e
Homo sapiens EKVX LC50 25118.86 nM 10.1021/np000020e
Homo sapiens HCC 2998 LC50 25118.86 nM 10.1021/np000020e
Homo sapiens HCT-116 LC50 25118.86 nM 10.1021/np000020e
Homo sapiens HCT-15 LC50 25118.86 nM 10.1021/np000020e
Homo sapiens HOP-18 LC50 25118.86 nM 10.1021/np000020e
Homo sapiens HOP-62 LC50 25118.86 nM 10.1021/np000020e
Homo sapiens HOP-92 LC50 25118.86 nM 10.1021/np000020e
Homo sapiens Hs-578T LC50 25118.86 nM 10.1021/np000020e
Homo sapiens HT-29 LC50 25118.86 nM 10.1021/np000020e
Homo sapiens IGROV-1 LC50 25118.86 nM 10.1021/np000020e
Homo sapiens K562 LC50 25118.86 nM 10.1021/np000020e
Homo sapiens KM12 LC50 25118.86 nM 10.1021/np000020e
Homo sapiens KM-20L2 LC50 25118.86 nM 10.1021/np000020e
Homo sapiens LOX IMVI LC50 25118.86 nM 10.1021/np000020e
Homo sapiens M14 LC50 25118.86 nM 10.1021/np000020e
Homo sapiens M19-MEL LC50 25118.86 nM 10.1021/np000020e
Homo sapiens Malme-3M LC50 25118.86 nM 10.1021/np000020e
Homo sapiens MCF7 LC50 25118.86 nM 10.1021/np000020e
Homo sapiens MDA-MB-231 LC50 25118.86 nM 10.1021/np000020e
Homo sapiens MDA-MB-435 LC50 25118.86 nM 10.1021/np000020e
Homo sapiens MDA-N LC50 25118.86 nM 10.1021/np000020e
Homo sapiens MOLT-4 LC50 25118.86 nM 10.1021/np000020e
Homo sapiens NCI-H226 LC50 25118.86 nM 10.1021/np000020e
Homo sapiens NCI-H23 LC50 25118.86 nM 10.1021/np000020e
Homo sapiens NCI-H322M LC50 25118.86 nM 10.1021/np000020e
Homo sapiens NCI-H460 LC50 25118.86 nM 10.1021/np000020e
Homo sapiens NCI-H522 LC50 25118.86 nM 10.1021/np000020e
Homo sapiens PC-3 LC50 25118.86 nM 10.1021/np000020e
Homo sapiens RXF 393 LC50 25118.86 nM 10.1021/np000020e
Homo sapiens SF-268 LC50 25118.86 nM 10.1021/np000020e
Homo sapiens SF-295 LC50 25118.86 nM 10.1021/np000020e
Homo sapiens SF-539 LC50 25118.86 nM 10.1021/np000020e
Homo sapiens SK-MEL-2 LC50 25118.86 nM 10.1021/np000020e
Homo sapiens SK-MEL-28 LC50 25118.86 nM 10.1021/np000020e
Homo sapiens SK-MEL-5 LC50 25118.86 nM 10.1021/np000020e
Homo sapiens SK-OV-3 LC50 25118.86 nM 10.1021/np000020e
Homo sapiens SN12C LC50 25118.86 nM 10.1021/np000020e
Homo sapiens SNB-19 LC50 25118.86 nM 10.1021/np000020e
Homo sapiens SNB-75 LC50 25118.86 nM 10.1021/np000020e
Homo sapiens SR LC50 25118.86 nM 10.1021/np000020e
Homo sapiens SW-620 LC50 25118.86 nM 10.1021/np000020e
Homo sapiens T47D LC50 25118.86 nM 10.1021/np000020e
Homo sapiens TK-10 LC50 25118.86 nM 10.1021/np000020e
Homo sapiens U-251 LC50 25118.86 nM 10.1021/np000020e
Homo sapiens UACC-257 LC50 25118.86 nM 10.1021/np000020e
Homo sapiens UACC-62 LC50 25118.86 nM 10.1021/np000020e
Homo sapiens UO-31 LC50 25118.86 nM 10.1021/np000020e
Homo sapiens XF498 LC50 25118.86 nM 10.1021/np000020e
None NON-PROTEIN TARGET LC50 25118.86 nM 10.1021/np000020e

Metabolism Information