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name Structure Reference Source Properties Activities Metabolism

(3R)-3-(ammoniomethyl)-5-methylhexanoate

AlkaPlorer ID: AK022945

Synonym: None

IUPAC Name: (3S)-3-(aminomethyl)-5-methylhexanoic acid

Structure

SMILES: CC(C)C[C@H](CN)CC(=O)O

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InChI: InChI=1S/C8H17NO2/c1-6(2)3-7(5-9)4-8(10)11/h6-7H,3-5,9H2,1-2H3,(H,10,11)/t7-/m0/s1

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InChIKey: AYXYPKUFHZROOJ-ZETCQYMHSA-N

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Reference

PubChem CID: 5486971

CAS: 148553-50-8

NPASS: NPC484296

Source

Species Genus Family Order Class Phylum Kingdom Domain
Olea europaea Olea Oleaceae Lamiales Magnoliopsida Streptophyta Viridiplantae Eukaryota

Properties Information

Molecule Weight: 159.229

TPSA？: 63.32000000000001

MolLogP？: 1.0821

Number of H-Donors: 2

Number of H-Acceptors: 2

RingCount: 0

Activities Information

Organism Target Name Standard Type Standard Value Standard Units doi
Homo sapiens 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase Activity 2.98 % 10.1021/acs.jmedchem.0c01762
Homo sapiens 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase Activity 97.0 % 10.1021/acs.jmedchem.0c01762
Homo sapiens Acetylcholinesterase AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Adenosine A1 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Adenosine A2a receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Adenosine A3 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-1a adrenergic receptor AC50 3671.6 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-1a adrenergic receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-2a adrenergic receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-2b adrenergic receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-2c adrenergic receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Beta-1 adrenergic receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Beta-2 adrenergic receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Beta-3 adrenergic receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Bile salt export pump AC50 300000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Bile salt export pump IC50 133000.0 nM 10.1093/toxsci/kft176
Homo sapiens Bradykinin B1 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Bradykinin B2 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Canalicular multispecific organic anion transporter 1 IC50 133000.0 nM 10.1093/toxsci/kft176
Homo sapiens Canalicular multispecific organic anion transporter 2 IC50 133000.0 nM 10.1093/toxsci/kft176
Homo sapiens Cannabinoid CB1 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Cholecystokinin A receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Cholecystokinin B receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Corticotropin releasing factor receptor 1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Corticotropin releasing factor receptor 2 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Cyclooxygenase-2 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Cytochrome P450 3A4 Inhibition 43.0 % 10.1021/acsmedchemlett.1c00416
Homo sapiens Delta opioid receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine D1 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine D2 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine D3 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine transporter AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Endothelin receptor ET-A AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Endothelin receptor ET-B AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Epidermal growth factor receptor erbB1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Equilibrative nucleoside transporter 1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Estrogen receptor alpha AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Estrogen receptor beta AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Gamma-aminobutyric acid receptor subunit alpha-1/alpha-2/beta-2/gamma-2 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Gastric inhibitory polypeptide receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Ghrelin receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Glucagon receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Glucocorticoid receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens HERG AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Histamine H1 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Histamine H2 receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Histamine H3 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Histone deacetylase 6 Inhibition 1.67 % 10.6019/CHEMBL4808148
Homo sapiens Histone deacetylase 6 Inhibition 14.57 % 10.6019/CHEMBL4808148
Homo sapiens Homo sapiens DILI_Concern nan None 10.1016/j.drudis.2016.02.015
Homo sapiens Homo sapiens DILI_severity_class 0.0 None 10.1016/j.drudis.2016.02.015
Homo sapiens Kappa opioid receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Melanocortin receptor 3 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Melanocortin receptor 4 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Monoamine oxidase A AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Motilin receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Multidrug resistance-associated protein 4 IC50 133000.0 nM 10.1093/toxsci/kft176
Homo sapiens Mu opioid receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Muscarinic acetylcholine receptor M1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Muscarinic acetylcholine receptor M2 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Muscarinic acetylcholine receptor M3 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Neuronal acetylcholine receptor protein alpha-4 subunit AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Neuropeptide Y receptor type 1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Neuropeptide Y receptor type 2 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Neurotensin receptor 1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Norepinephrine transporter AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Norepinephrine transporter IC50 10000.0 nM 10.1021/acs.jmedchem.0c01867
Homo sapiens Norepinephrine transporter Ki 10000.0 nM 10.1021/acs.jmedchem.0c01867
Homo sapiens Peroxisome proliferator-activated receptor gamma AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Phosphodiesterase 3A AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Phosphodiesterase 4D AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Pregnane X receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Progesterone receptor AC50 20219.9 nM 10.1038/s41467-023-40064-9
Homo sapiens Progesterone receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Receptor protein-tyrosine kinase erbB-2 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 1a (5-HT1a) receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 1a (5-HT1a) receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2a (5-HT2a) receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2a (5-HT2a) receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2b (5-HT2b) receptor AC50 28000.1 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2b (5-HT2b) receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2c (5-HT2c) receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 3a (5-HT3a) receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin transporter AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Solute carrier organic anion transporter family member 1B1 Inhibition 120.58 % 10.1124/mol.112.084152
Homo sapiens Solute carrier organic anion transporter family member 1B3 Inhibition 101.4 % 10.1124/mol.112.084152
Homo sapiens Thromboxane A2 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Type-1 angiotensin II receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Vascular endothelial growth factor receptor 2 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Vasopressin V1a receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Vasopressin V2 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Voltage-gated calcium channel alpha2/delta subunit 1 INH 0.039 uM 10.1016/j.bmcl.2018.05.006
Homo sapiens Voltage-gated calcium channel alpha2/delta subunit 1 Ki 19.0 nM 10.1021/acs.jmedchem.0c01867
Homo sapiens Voltage-gated calcium channel alpha2/delta subunit 1 Ki 19.0 nM 10.1021/acsmedchemlett.1c00416
Homo sapiens Voltage-gated calcium channel alpha2/delta subunit 1 T1/2 1.5 hr 10.1021/acs.jmedchem.1c00208
Homo sapiens Voltage-gated calcium channel alpha2/delta subunit 2 Ki 99.0 nM 10.1021/acs.jmedchem.0c01867
Homo sapiens Voltage-gated calcium channel alpha2/delta subunit 2 T1/2 1.5 hr 10.1021/acs.jmedchem.1c00208
Mus musculus Mus musculus Activity 34.0 % 10.1021/acsmedchemlett.1c00416
Mus musculus Mus musculus Activity 98.0 % 10.1016/j.bmcl.2018.05.006
Mus musculus Mus musculus Activity 100.0 % 10.1016/j.bmcl.2005.06.090
Mus musculus Mus musculus Activity 100.0 % 10.1016/j.bmcl.2006.03.083
Mus musculus Mus musculus Activity 100.0 % 10.1016/j.bmcl.2008.10.101
Mus musculus Mus musculus Activity nan None 10.1016/j.bmcl.2012.10.001
Mus musculus Mus musculus Activity nan None 10.1016/j.bmcl.2018.05.006
Mus musculus Mus musculus Activity nan None 10.1016/j.ejmech.2019.05.026
Mus musculus Mus musculus Activity nan None 10.1016/j.ejmech.2022.114413
Mus musculus Mus musculus Activity nan None 10.1021/acs.jmedchem.6b01496
Mus musculus Mus musculus Activity nan None 10.1021/acs.jmedchem.9b02163
Mus musculus Mus musculus Activity nan None 10.1021/acs.jnatprod.0c00793
Mus musculus Mus musculus Activity nan None 10.1021/jm3007323
Mus musculus Mus musculus Activity nan None 10.1021/np300783a
Mus musculus Mus musculus AUC 18940000.0 ng.hr.mL-1 10.1016/j.bmcl.2018.05.006
Mus musculus Mus musculus CL 7.77 mL.min-1.kg-1 10.1016/j.bmcl.2018.05.006
Mus musculus Mus musculus Cmax 8415.5 nM 10.1016/j.bmcl.2018.05.006
Mus musculus Mus musculus ED50 20.0 mg.kg-1 10.1016/S0960-894X(01)80855-6
Mus musculus Mus musculus Efficacy 57.0 % 10.1016/j.bmc.2013.08.031
Mus musculus Mus musculus Efficacy 69.0 % 10.1016/j.bmc.2013.08.031
Mus musculus Mus musculus Efficacy 73.0 % 10.1016/j.bmc.2013.08.031
Mus musculus Mus musculus F 88.0 % 10.1016/j.bmcl.2018.05.006
Mus musculus Mus musculus Inhibition nan % 10.1021/jm3007323
Mus musculus Mus musculus Protection 100.0 % 10.1021/jm049762l
Mus musculus Mus musculus T1/2 2.54 hr 10.1016/j.bmcl.2018.05.006
Rattus norvegicus Androgen Receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Rattus norvegicus Brain Drug uptake 7360.0 ng/ml 10.1016/j.bmcl.2008.10.101
Rattus norvegicus Cyclooxygenase-1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Rattus norvegicus GABA receptor alpha-1 subunit AC50 30000.0 nM 10.1038/s41467-023-40064-9
Rattus norvegicus Glutamate (NMDA) receptor subunit zeta 1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Rattus norvegicus P2X purinoceptor 7 Inhibition 31.0 % 10.1021/jm500324g
Rattus norvegicus Rattus norvegicus Activity 5.8 g 10.1021/acsmedchemlett.5b00059
Rattus norvegicus Rattus norvegicus Activity 58.0 % 10.1021/jm301056k
Rattus norvegicus Rattus norvegicus Activity 100.0 % 10.1016/j.bmcl.2005.06.090
Rattus norvegicus Rattus norvegicus Activity nan None 10.1016/j.bmcl.2010.05.026
Rattus norvegicus Rattus norvegicus Activity nan None 10.1016/j.bmcl.2012.10.001
Rattus norvegicus Rattus norvegicus Activity nan None 10.1016/j.bmcl.2019.04.015
Rattus norvegicus Rattus norvegicus Activity nan None 10.1016/j.ejmech.2018.09.021
Rattus norvegicus Rattus norvegicus Activity nan None 10.1039/C7MD00131B
Rattus norvegicus Rattus norvegicus Activity nan None None
Rattus norvegicus Rattus norvegicus AUC 5.8 g.hr 10.1016/j.bmcl.2018.05.006
Rattus norvegicus Rattus norvegicus AUC 18.0 g.hr 10.1016/j.bmcl.2018.05.006
Rattus norvegicus Rattus norvegicus AUC 14800.0 ng.hr.mL-1 10.1016/j.bmcl.2008.10.101
Rattus norvegicus Rattus norvegicus B/P 0.22 None 10.1021/jm0491086
Rattus norvegicus Rattus norvegicus Brain level 4330.0 ng ml-1 10.1021/jm0491086
Rattus norvegicus Rattus norvegicus CITH 52.0 None 10.1021/jm049762l
Rattus norvegicus Rattus norvegicus CL 2.9 mL.min-1.kg-1 10.1016/j.bmcl.2008.10.101
Rattus norvegicus Rattus norvegicus Cp 25643.0 ng/ml 10.1016/j.bmcl.2008.10.101
Rattus norvegicus Rattus norvegicus ED50 42.2 mg.kg-1 10.1016/j.bmcl.2014.05.074
Rattus norvegicus Rattus norvegicus Efficacy 20.0 % 10.1016/j.bmcl.2020.127636
Rattus norvegicus Rattus norvegicus F 83.0 % 10.1016/j.bmcl.2008.10.101
Rattus norvegicus Rattus norvegicus Inhibition nan % 10.1016/j.bmcl.2014.05.016
Rattus norvegicus Rattus norvegicus Inhibition nan % 10.1021/jm5006429
Rattus norvegicus Rattus norvegicus MED 10.0 mg kg-1 10.1016/j.bmcl.2009.10.089
Rattus norvegicus Rattus norvegicus Plasma level 19367.0 ng ml-1 10.1021/jm0491086
Rattus norvegicus Rattus norvegicus PWT 3.43 g 10.1016/j.bmcl.2004.02.094
Rattus norvegicus Rattus norvegicus PWT 18.86 g 10.1016/j.bmcl.2004.02.094
Rattus norvegicus Rattus norvegicus T1/2 2.7 hr 10.1016/j.bmcl.2008.10.101
Rattus norvegicus Rattus norvegicus TIME 0.00425 hr 10.1021/jm101376k
Rattus norvegicus Rattus norvegicus TIME 0.004361 hr 10.1021/jm101376k
Rattus norvegicus Rattus norvegicus TIME 0.004472 hr 10.1021/jm101376k
Rattus norvegicus Rattus norvegicus TIME 0.004639 hr 10.1021/jm101376k
Rattus norvegicus Rattus norvegicus TIME 0.004722 hr 10.1021/jm101376k
Rattus norvegicus Rattus norvegicus TIME 0.00475 hr 10.1021/jm101376k
Rattus norvegicus Rattus norvegicus TIME 2.0 hr 10.1016/j.bmcl.2014.05.016
Rattus norvegicus Rattus norvegicus Vdss 0.79 L.kg-1 10.1016/j.bmcl.2008.10.101
Rattus norvegicus Rattus norvegicus WLC PRA 100.0 None 10.1021/jm049762l
Rattus norvegicus Voltage-gated L-type calcium channel alpha-1C subunit AC50 30000.0 nM 10.1038/s41467-023-40064-9
Rattus norvegicus Voltage-gated N-type calcium channel alpha-1B subunit AC50 10000.0 nM 10.1038/s41467-023-40064-9
Severe acute respiratory syndrome coronavirus 2 Replicase polyprotein 1ab Inhibition 12.13 % 10.6019/CHEMBL4495564
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Inhibition 0.04 % 10.6019/CHEMBL4495565
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Inhibition 5.38 % 10.21203/rs.3.rs-23951/v1
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Inhibition index 0.7622 None 10.1101/2020.04.03.023846
Sus scrofa Voltage-dependent calcium channel alpha2delta subunit IC50 73.0 nM 10.1016/j.bmcl.2005.06.090
Sus scrofa Voltage-dependent calcium channel alpha2delta subunit IC50 80.0 nM 10.1016/j.bmcl.2009.10.089
None ADMET Activity nan None 10.1021/acs.jmedchem.6b00571
None ADMET PPB 50.0 % 10.6019/CHEMBL3301361
None ADMET Ratio 0.29 None 10.1016/j.bmcl.2008.10.101
None Hepatotoxicity HepSE_bilirubinemia 1.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_cholecystitis 1.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_cholelithiasis 1.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_cirrhosis 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_Combined Scores 8.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_elevated liver function tests 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_hepatic failure 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_hepatic necrosis 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_hepatitis 1.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_hepatomegaly 1.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_jaundice 1.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_liver disease 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_liver fatty 1.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_liver function tests abnormal 1.0 None 10.1371/journal.pcbi.1002310
None NON-PROTEIN TARGET Inhibition 31.0 % 10.1016/j.ejmech.2013.10.026
None Unchecked Ac50 0.631 uM None
None Unchecked Ac50 0.8913 uM None
None Unchecked Ac50 7.943 uM None
None Unchecked AC50 631.0 nM None
None Unchecked AC50 891.3 nM None
None Unchecked AC50 7950.0 nM None
None Unchecked Activity 14.1 % 10.1016/j.bmc.2016.11.052
None Unchecked Activity 15.0 % 10.1016/j.bmc.2016.11.052
None Unchecked Activity 24.34 % 10.1016/j.bmc.2016.11.052
None Unchecked Activity 26.2 % 10.1016/j.bmc.2016.11.052
None Unchecked Activity 182.1 pmol/min.mg 10.1016/j.bmc.2015.06.038
None Unchecked Activity 210.7 pmol/min.mg 10.1016/j.bmc.2015.06.038
None Unchecked Activity nan None 10.1016/j.bmc.2015.06.038
None Unchecked Activity nan None 10.1016/j.bmc.2016.11.052
None Unchecked Activity nan None 10.1021/acsmedchemlett.1c00416
None Unchecked IC50 37.0 nM 10.1016/S0960-894X(01)80855-6
None Unchecked IC50 80.0 nM 10.1016/j.bmcl.2008.10.101
None Unchecked IC50 80.0 nM 10.1016/j.bmcl.2009.10.121
None Unchecked IC50 80.0 nM 10.1016/j.bmcl.2011.04.045
None Unchecked IC50 80.0 nM 10.1016/j.bmcl.2011.04.056
None Unchecked IC50 80.0 nM 10.1016/j.bmcl.2011.04.058
None Unchecked IC50 80.0 nM 10.1021/jm049762l
None Unchecked IC50 158000.0 nM 10.1016/j.bmcl.2008.10.101
None Unchecked IC50 158000.0 nM 10.1021/jm0491086
None Unchecked IC50 158000.0 nM 10.1021/jm049762l
None Unchecked IC50 284000.0 nM 10.1016/j.bmcl.2005.06.090
None Unchecked Inhibition 25.0 % 10.1016/S0960-894X(01)80855-6
None Unchecked Inhibition 50.0 % 10.1016/S0960-894X(01)80855-6
None Unchecked Inhibition 75.0 % 10.1016/S0960-894X(01)80855-6
None Unchecked Inhibition 85.0 % 10.1016/S0960-894X(01)80855-6
None Unchecked Inhibition 90.0 % 10.1016/S0960-894X(01)80855-6
None Unchecked Inhibition 92.0 % 10.1016/j.ejmech.2009.12.049
None Unchecked Inhibition 94.0 % 10.1016/S0960-894X(01)80855-6
None Unchecked Inhibition 98.0 % 10.1016/S0960-894X(01)80855-6
None Unchecked Inhibition 100.0 % 10.1016/S0960-894X(01)80855-6
None Unchecked Ki 19.0 nM 10.1016/j.bmcl.2006.03.083
None Unchecked Ki 19.0 nM 10.1021/jm0491086

Metabolism Information