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name Structure Reference Source Properties Activities Metabolism

UCN-01

AlkaPlorer ID: AK023048

Synonym: None

IUPAC Name: (2S,3R,4R,6R,18S)-18-hydroxy-3-methoxy-2-methyl-4-(methylamino)-29-oxa-1,7,17-triazaoctacyclo[12.12.2.12,6.07,28.08,13.015,19.020,27.021,26]nonacosa-8,10,12,14,19,21,23,25,27-nonaen-16-one

Structure

SMILES: CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)N1C3=CC=CC=C3C3=C4C(=C5C6=CC=CC=C6N2C5=C31)C(O)=N[C@H]4O

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InChI: InChI=1S/C28H26N4O4/c1-28-25(35-3)15(29-2)12-18(36-28)31-16-10-6-4-8-13(16)19-21-22(27(34)30-26(21)33)20-14-9-5-7-11-17(14)32(28)24(20)23(19)31/h4-11,15,18,25,27,29,34H,12H2,1-3H3,(H,30,33)/t15-,18-,25-,27+,28+/m1/s1

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InChIKey: PBCZSGKMGDDXIJ-KRUBCLEUSA-N

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Source

Species Genus Family Order Class Phylum Kingdom Domain
Streptomyces sp. Streptomyces Streptomycetaceae Kitasatosporales Actinomycetes Actinomycetota None Bacteria

Properties Information

Molecule Weight: 482.54000000000025

TPSA？: 93.17

MolLogP？: 4.419700000000003

Number of H-Donors: 3

Number of H-Acceptors: 7

RingCount: 8

Activities Information

Organism Target Name Standard Type Standard Value Standard Units doi
Gallus gallus Tyrosine-protein kinase SRC Activity 76.0 % 10.1042/bj20070797
Homo sapiens 26S protease regulatory subunit 6B Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens 3-phosphoinositide dependent protein kinase-1 Activity 2.0 % 10.1042/bj20070797
Homo sapiens Actin-related protein 2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Actin-related protein 3 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Activin receptor type-1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Activin receptor type-1B Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Activin receptor type-2B Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Acyl-CoA dehydrogenase family member 10 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Acyl-CoA dehydrogenase family member 11 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Adaptor-associated kinase Kd 623.0 nM 10.1126/science.aan4368
Homo sapiens Adenine phosphoribosyltransferase Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Adenosine kinase Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Adenylate kinase 2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens ADP/ATP translocase 2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens ADP/ATP translocase 3 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens ALK tyrosine kinase receptor Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens AMP-activated protein kinase, alpha-1 subunit Kd 319.0 nM 10.1126/science.aan4368
Homo sapiens AMP-activated protein kinase, gamma-1 subunit Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens AMP-activated protein kinase, gamma-2 subunit Kd 25.0 nM 10.1126/science.aan4368
Homo sapiens ATP-dependent RNA helicase DDX3X Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens ATP-dependent RNA helicase DDX42 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens ATP-dependent RNA helicase DHX30 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens BMP-2-inducible protein kinase Kd 832.0 nM 10.1126/science.aan4368
Homo sapiens Bone morphogenetic protein receptor type-1A Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Bone morphogenetic protein receptor type-1B Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Bone morphogenetic protein receptor type-2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Brain glycogen phosphorylase Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Breakpoint cluster region protein Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens BR serine/threonine-protein kinase 2 Activity 27.0 % 10.1042/bj20070797
Homo sapiens CaM kinase I alpha Activity 86.0 % 10.1042/bj20070797
Homo sapiens CaM kinase II delta Kd 520.0 nM 10.1126/science.aan4368
Homo sapiens CaM kinase II gamma Kd 823.0 nM 10.1126/science.aan4368
Homo sapiens CaM kinase IV Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens CaM-kinase kinase alpha Activity 58.0 % 10.1042/bj20070797
Homo sapiens CaM-kinase kinase beta Activity 21.0 % 10.1042/bj20070797
Homo sapiens CaM-kinase kinase beta Kd 30.0 nM 10.1126/science.aan4368
Homo sapiens cAMP-dependent protein kinase alpha-catalytic subunit Activity 63.0 % 10.1042/bj20070797
Homo sapiens cAMP-dependent protein kinase alpha-catalytic subunit Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens cAMP-dependent protein kinase beta-1 catalytic subunit Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens cAMP-dependent protein kinase, gamma catalytic subunit Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens cAMP-dependent protein kinase (PKA) IC50 42.0 nM 10.1016/S0960-894X(00)80167-5
Homo sapiens cAMP-dependent protein kinase (PKA) IC50 250.0 nM 10.1016/S0960-894X(00)80167-5
Homo sapiens cAMP-dependent protein kinase type II-alpha regulatory subunit Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Casein kinase I alpha Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Casein kinase I delta Activity 96.0 % 10.1042/bj20070797
Homo sapiens Casein kinase I delta Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Casein kinase I epsilon Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Casein kinase I gamma 1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Casein kinase I gamma 2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Casein kinase II Activity 92.0 % 10.1042/bj20070797
Homo sapiens Casein kinase II alpha (prime) Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Casein kinase I isoform gamma-3 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens CCRF-CEM Activity nan None 10.1016/j.bmc.2010.09.042
Homo sapiens cGMP-dependent protein kinase 1 beta Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Chaperone activity of bc1 complex-like, mitochondrial Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Chromodomain-helicase-DNA-binding protein 4 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Citron Rho-interacting kinase Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens c-Jun N-terminal kinase 1 Activity 79.0 % 10.1042/bj20070797
Homo sapiens c-Jun N-terminal kinase 1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens c-Jun N-terminal kinase 2 Activity 92.0 % 10.1042/bj20070797
Homo sapiens c-Jun N-terminal kinase 2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens c-Jun N-terminal kinase 3 Activity 107.0 % 10.1042/bj20070797
Homo sapiens c-Jun N-terminal kinase 3 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Cyclin-dependent kinase 1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Cyclin-dependent kinase 12 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Cyclin-dependent kinase 13 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Cyclin-dependent kinase 2 IC50 30.0 nM 10.1007/s00044-009-9233-5
Homo sapiens Cyclin-dependent kinase 2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Cyclin-dependent kinase 2/cyclin A Activity 44.0 % 10.1042/bj20070797
Homo sapiens Cyclin-dependent kinase 4 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Cyclin-dependent kinase 5 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Cyclin-dependent kinase 6 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Cyclin-dependent kinase 7 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Cyclin-dependent kinase 9 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Cyclin-dependent kinase-like 5 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Cysteine--tRNA ligase, cytoplasmic Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Cytochrome c1, heme protein, mitochondrial Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens dCTP pyrophosphatase 1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Delta(24)-sterol reductase Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Deoxycytidine kinase Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Discoidin domain-containing receptor 2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens DnaJ homolog subfamily A member 1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens DNA replication licensing factor MCM4 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens DNA topoisomerase II alpha Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens DNA topoisomerase II beta Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 1 Activity 75.0 % 10.1042/bj20070797
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 3 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 4 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 5 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 6 Kd 792.0 nM 10.1126/science.aan4368
Homo sapiens Dual specificity protein kinase CLK2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Dual specificity testis-specific protein kinase 1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Dual specificity testis-specific protein kinase 2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 1A Activity 90.0 % 10.1042/bj20070797
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 1A Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 2 Activity 92.0 % 10.1042/bj20070797
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 3 Activity 84.0 % 10.1042/bj20070797
Homo sapiens Dual specificty protein kinase CLK1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Dynamin-like 120 kDa protein, mitochondrial Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Elongation factor Tu, mitochondrial Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Ephrin type-A receptor 1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Ephrin type-A receptor 2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Ephrin type-A receptor 4 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Ephrin type-A receptor 5 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Ephrin type-A receptor 7 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Ephrin type-B receptor 2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Ephrin type-B receptor 3 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Ephrin type-B receptor 4 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Ephrin type-B receptor 6 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Epidermal growth factor receptor erbB1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Epithelial discoidin domain-containing receptor 1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Eukaryotic translation initiation factor 2-alpha kinase 1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Exosome RNA helicase MTR4 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Ferrochelatase, mitochondrial Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Fibroblast growth factor receptor 1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Focal adhesion kinase 1 Kd 436.0 nM 10.1126/science.aan4368
Homo sapiens General transcription and DNA repair factor IIH helicase subunit XPD Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Glycine--tRNA ligase Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Glycogen synthase kinase-3 alpha Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Glycogen synthase kinase-3 beta Activity 77.0 % 10.1042/bj20070797
Homo sapiens Glycogen synthase kinase-3 beta Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens G-protein coupled receptor kinase 2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens G protein-coupled receptor kinase 6 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens GTP-binding nuclear protein Ran Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Guanine nucleotide-binding protein G(i) subunit alpha-2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Heme oxygenase 2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Hepatocyte growth factor receptor Kd 937.0 nM 10.1126/science.aan4368
Homo sapiens Homeodomain-interacting protein kinase 2 Activity 109.0 % 10.1042/bj20070797
Homo sapiens Homeodomain-interacting protein kinase 3 Activity 116.0 % 10.1042/bj20070797
Homo sapiens Inhibitor of nuclear factor kappa B kinase beta subunit Activity 86.0 % 10.1042/bj20070797
Homo sapiens Inhibitor of nuclear factor kappa B kinase epsilon subunit Kd 528.0 nM 10.1126/science.aan4368
Homo sapiens Inosine-5'-monophosphate dehydrogenase 2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Insulin-like growth factor I receptor Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Insulin receptor Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Interleukin-1 receptor-associated kinase 1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Interleukin-1 receptor-associated kinase 3 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Interleukin-1 receptor-associated kinase 4 Kd 895.0 nM 10.1126/science.aan4368
Homo sapiens LIM domain kinase 1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens LIM domain kinase 2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Liver glycogen phosphorylase Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Long-chain-fatty-acid--CoA ligase 5 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Macrophage-stimulating protein receptor Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens MAP kinase-activated protein kinase 2 Activity 75.0 % 10.1042/bj20070797
Homo sapiens MAP kinase-activated protein kinase 2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens MAP kinase-activated protein kinase 3 Activity 107.0 % 10.1042/bj20070797
Homo sapiens MAP kinase-activated protein kinase 3 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens MAP kinase-activated protein kinase 5 Activity 83.0 % 10.1042/bj20070797
Homo sapiens MAP kinase-activated protein kinase 5 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens MAP kinase ERK1 Activity 112.0 % 10.1042/bj20070797
Homo sapiens MAP kinase ERK1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens MAP kinase ERK2 Activity 89.0 % 10.1042/bj20070797
Homo sapiens MAP kinase ERK2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens MAP kinase-interacting serine/threonine-protein kinase MNK1 Activity 85.0 % 10.1042/bj20070797
Homo sapiens MAP kinase p38 alpha Activity 105.0 % 10.1042/bj20070797
Homo sapiens MAP kinase p38 alpha Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens MAP kinase p38 beta Activity 105.0 % 10.1042/bj20070797
Homo sapiens MAP kinase p38 beta Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens MAP kinase p38 delta Activity 94.0 % 10.1042/bj20070797
Homo sapiens MAP kinase p38 gamma Activity 104.0 % 10.1042/bj20070797
Homo sapiens MAP kinase signal-integrating kinase 2 Activity 103.0 % 10.1042/bj20070797
Homo sapiens MAP/microtubule affinity-regulating kinase 2 Kd 13.0 nM 10.1126/science.aan4368
Homo sapiens MAP/microtubule affinity-regulating kinase 4 Kd 8.0 nM 10.1126/science.aan4368
Homo sapiens Maternal embryonic leucine zipper kinase Activity 53.0 % 10.1042/bj20070797
Homo sapiens Maternal embryonic leucine zipper kinase Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Midasin Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Mitogen-activated protein kinase 15 Activity 92.0 % 10.1042/bj20070797
Homo sapiens Mitogen-activated protein kinase 15 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Mitogen-activated protein kinase 7 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Mitogen-activated protein kinase kinase kinase 1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Mitogen-activated protein kinase kinase kinase 11 Kd 303.0 nM 10.1126/science.aan4368
Homo sapiens Mitogen-activated protein kinase kinase kinase 2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Mitogen-activated protein kinase kinase kinase 3 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Mitogen-activated protein kinase kinase kinase 4 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Mitogen-activated protein kinase kinase kinase 5 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Mitogen-activated protein kinase kinase kinase 6 Kd 1185.0 nM 10.1126/science.aan4368
Homo sapiens Mitogen-activated protein kinase kinase kinase kinase 1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Mitogen-activated protein kinase kinase kinase kinase 2 Kd 631.0 nM 10.1126/science.aan4368
Homo sapiens Mitogen-activated protein kinase kinase kinase kinase 3 Kd 706.0 nM 10.1126/science.aan4368
Homo sapiens Mitogen-activated protein kinase kinase kinase kinase 4 Kd 832.0 nM 10.1126/science.aan4368
Homo sapiens Mitogen-activated protein kinase kinase kinase kinase 5 Kd 836.0 nM 10.1126/science.aan4368
Homo sapiens Mitotic checkpoint serine/threonine-protein kinase BUB1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Mixed lineage kinase 7 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Multifunctional protein ADE2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Myosin-14 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Myosin light chain kinase Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Myosin light chain kinase, smooth muscle Activity 83.0 % 10.1042/bj20070797
Homo sapiens Myosin light chain kinase, smooth muscle Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Nerve growth factor receptor Trk-A Kd 737.0 nM 10.1126/science.aan4368
Homo sapiens Non-receptor tyrosine-protein kinase TNK1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens NUAK family SNF1-like kinase 2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Nucleolar GTP-binding protein 1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens PAS domain-containing serine/threonine-protein kinase Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Peroxisomal acyl-coenzyme A oxidase 1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Peroxisomal acyl-coenzyme A oxidase 3 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Phenylalanine--tRNA ligase beta subunit Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Phosphatidylinositol-5-phosphate 4-kinase type-2 alpha Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Phosphatidylinositol-5-phosphate 4-kinase type-2 gamma Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Phosphofructokinase platelet type Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Phosphorylase kinase gamma subunit 2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Platelet-derived growth factor receptor beta Kd 436.0 nM 10.1126/science.aan4368
Homo sapiens Probable ATP-dependent RNA helicase DDX6 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Protein kinase C alpha Activity 6.0 % 10.1042/bj20070797
Homo sapiens Protein kinase C alpha Kd 35.0 nM 10.1126/science.aan4368
Homo sapiens Protein kinase C beta Kd 19.0 nM 10.1126/science.aan4368
Homo sapiens Protein kinase C delta Kd 38.0 nM 10.1126/science.aan4368
Homo sapiens Protein kinase C iota Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Protein kinase C mu Activity 83.0 % 10.1042/bj20070797
Homo sapiens Protein kinase C nu Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Protein kinase C (PKC) IC50 4.1 nM 10.1016/S0960-894X(00)80167-5
Homo sapiens Protein kinase C (PKC) IC50 62.0 nM 10.1016/S0960-894X(00)80167-5
Homo sapiens Protein kinase C theta Kd 1984.0 nM 10.1126/science.aan4368
Homo sapiens Protein kinase C zeta Activity 78.0 % 10.1042/bj20070797
Homo sapiens Protein kinase C zeta Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Protein kinase N1 Kd 8.0 nM 10.1126/science.aan4368
Homo sapiens Protein kinase N2 Activity 10.0 % 10.1042/bj20070797
Homo sapiens Protein kinase N2 Kd 142.0 nM 10.1126/science.aan4368
Homo sapiens Protein tyrosine kinase 2 beta Kd 191.0 nM 10.1126/science.aan4368
Homo sapiens Proto-oncogene tyrosine-protein kinase MER Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Putative heat shock protein HSP 90-beta 2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Pyridoxal kinase Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Quinone reductase 2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Rab-like protein 3 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Ras-related protein Rab-10 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Ras-related protein Rab-6A Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Receptor-interacting serine/threonine-protein kinase 3 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Rho-associated protein kinase 1 Kd 955.0 nM 10.1126/science.aan4368
Homo sapiens Rho-associated protein kinase 2 Activity 86.0 % 10.1042/bj20070797
Homo sapiens Rho-associated protein kinase 2 Kd 1096.0 nM 10.1126/science.aan4368
Homo sapiens Ribosomal protein S6 kinase 1 Activity 96.0 % 10.1042/bj20070797
Homo sapiens Ribosomal protein S6 kinase 1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Ribosomal protein S6 kinase alpha 1 Activity 25.0 % 10.1042/bj20070797
Homo sapiens Ribosomal protein S6 kinase alpha 1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Ribosomal protein S6 kinase alpha 3 Activity 29.0 % 10.1042/bj20070797
Homo sapiens Ribosomal protein S6 kinase alpha 3 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Ribosomal protein S6 kinase alpha 4 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Ribosomal protein S6 kinase alpha 5 Activity 68.0 % 10.1042/bj20070797
Homo sapiens Ribosomal protein S6 kinase alpha 5 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Ribosomal protein S6 kinase alpha 6 Kd 141.0 nM 10.1126/science.aan4368
Homo sapiens RNA cytidine acetyltransferase Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens S-adenosylmethionine synthase isoform type-2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Septin-9 Kd 635.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase 10 Kd 3.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase 11 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase 16 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase 2 Kd 89.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase 24 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase 38 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase 38-like Kd 414.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase AKT Activity 79.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase AKT Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase AKT2 Activity 77.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase AKT2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase AKT3 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase A-Raf Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase Aurora-A Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase Aurora-B Activity 59.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase Aurora-B Kd 670.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase Aurora-C Activity 71.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase B-raf Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase Chk1 Activity 12.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase Chk1 IC50 5.6 nM 10.1016/j.bmc.2010.09.042
Homo sapiens Serine/threonine-protein kinase Chk1 IC50 10.0 nM 10.1016/j.bmcl.2010.07.015
Homo sapiens Serine/threonine-protein kinase Chk1 Kd 33.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase Chk2 Activity 96.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase Chk2 IC50 10.0 nM 10.1016/j.bmcl.2010.07.015
Homo sapiens Serine/threonine-protein kinase c-TAK1 Activity 6.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase c-TAK1 Kd 16.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase D2 Kd 4236.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase EEF2K Activity 105.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase/endoribonuclease IRE1 Kd 1997.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase/endoribonuclease IRE2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase GAK Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase ICK Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase ILK-1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase LATS1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase MRCK-A Kd 254.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase MRCK beta Kd 110.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase MRCK gamma Kd 269.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase MST1 Kd 114.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase MST2 Activity 2.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase MST2 Kd 45.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase MST4 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase N3 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase Nek1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase NEK2 Activity 85.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase NEK2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase Nek3 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase NEK6 Activity 104.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase NEK7 Activity 99.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase NEK9 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine protein kinase NLK Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase PAK 2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase PAK 4 Activity 33.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase PAK 4 Kd 25.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase PAK6 Activity 35.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase PAK6 Kd 4.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase PAK7 Activity 36.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase PCTAIRE-1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase PCTAIRE-2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase PIM1 Activity 52.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase PIM1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase PIM2 Activity 73.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase PIM2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase PIM3 Activity 8.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase PLK1 Activity 76.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase PLK4 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase RIPK2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase Sgk1 Activity 83.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase SIK2 Kd 11.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase SIK3 Kd 56.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase SRPK1 Activity 71.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase TAO1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase TAO2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase TAO3 Kd 1411.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase TBK1 Kd 393.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase ULK1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase ULK3 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase WEE1 Kd 1101.0 nM 10.1126/science.aan4368
Homo sapiens Signal recognition particle receptor subunit alpha Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens STE20-related kinase adapter protein alpha Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Structural maintenance of chromosomes protein 1A Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Structural maintenance of chromosomes protein 2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens TGF-beta receptor type I Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens TGF-beta receptor type II Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Thyroid hormone receptor-associated protein 3 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens TP53-regulating kinase Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens TRAF2- and NCK-interacting kinase Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Tyrosine- and threonine-specific cdc2-inhibitory kinase Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Tyrosine kinase non-receptor protein 2 Kd 162.0 nM 10.1126/science.aan4368
Homo sapiens Tyrosine-protein kinase ABL Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Tyrosine-protein kinase ABL2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Tyrosine-protein kinase BRK Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Tyrosine-protein kinase BTK Kd 386.0 nM 10.1126/science.aan4368
Homo sapiens Tyrosine-protein kinase CSK Activity 80.0 % 10.1042/bj20070797
Homo sapiens Tyrosine-protein kinase CSK Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Tyrosine-protein kinase FER Kd 430.0 nM 10.1126/science.aan4368
Homo sapiens Tyrosine-protein kinase FES Kd 2314.0 nM 10.1126/science.aan4368
Homo sapiens Tyrosine-protein kinase FRK Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Tyrosine-protein kinase FYN Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Tyrosine-protein kinase HCK Kd 621.0 nM 10.1126/science.aan4368
Homo sapiens Tyrosine-protein kinase JAK1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Tyrosine-protein kinase LCK Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Tyrosine-protein kinase Lyn Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Tyrosine-protein kinase receptor FLT3 Kd 67.0 nM 10.1126/science.aan4368
Homo sapiens Tyrosine-protein kinase receptor RET Kd 521.0 nM 10.1126/science.aan4368
Homo sapiens Tyrosine-protein kinase SRC Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Tyrosine-protein kinase SYK Kd 217.0 nM 10.1126/science.aan4368
Homo sapiens Tyrosine-protein kinase TEC Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Tyrosine-protein kinase TYK2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Tyrosine-protein kinase YES Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Tyrosyl-tRNA synthetase Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens U5 small nuclear ribonucleoprotein 200 kDa helicase Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Uncharacterized aarF domain-containing protein kinase 1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Uncharacterized aarF domain-containing protein kinase 5 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Uncharacterized protein FLJ45252 Kd 961.0 nM 10.1126/science.aan4368
Homo sapiens Very long-chain specific acyl-CoA dehydrogenase, mitochondrial Kd 30000.0 nM 10.1126/science.aan4368
Mus musculus Tyrosine-protein kinase LCK Activity 50.0 % 10.1042/bj20070797
None ADMET BPR 0.5 None 10.1021/acs.jmedchem.6b00618
None NON-PROTEIN TARGET Activity nan None 10.1016/j.bmc.2010.09.042
None Unchecked Activity 5.0 % 10.1042/bj20070797
None Unchecked Activity 9.0 % 10.1042/bj20070797
None Unchecked Kd 8.0 nM 10.1126/science.aan4368
None Unchecked Kd 30000.0 nM 10.1126/science.aan4368

Metabolism Information