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name Structure Reference Source Properties Activities Metabolism

3-[(carbamoyloxy)methyl]-7-[(2E)-2-(furan-2-yl)-2-(methoxyimino)acetamido]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

AlkaPlorer ID: AK023563

Synonym: None

IUPAC Name: (6R,7R)-3-(carbamoyloxymethyl)-7-[[(2E)-2-(furan-2-yl)-2-methoxyiminoacetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

Structure

SMILES: CO/N=C(\C(O)=N[C@@H]1C(=O)N2C(C(=O)O)=C(COC(=N)O)CS[C@H]12)C1=CC=CO1

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InChI: InChI=1S/C16H16N4O8S/c1-26-19-9(8-3-2-4-27-8)12(21)18-10-13(22)20-11(15(23)24)7(5-28-16(17)25)6-29-14(10)20/h2-4,10,14H,5-6H2,1H3,(H2,17,25)(H,18,21)(H,23,24)/b19-9-/t10-,14-/m1/s1

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InChIKey: JFPVXVDWJQMJEE-IZRZKJBUSA-N

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Source

Species Genus Family Order Class Phylum Kingdom Domain

Properties Information

Molecule Weight: 424.3910000000001

TPSA？: 178.24

MolLogP？: 0.7183700000000013

Number of H-Donors: 4

Number of H-Acceptors: 9

RingCount: 3

Activities Information

Organism Target Name Standard Type Standard Value Standard Units doi
Acinetobacter baumannii Acinetobacter baumannii MIC 32.0 ug.mL-1 10.1128/aac.00050-10
Acinetobacter baumannii Acinetobacter baumannii MIC 32.0 ug.mL-1 10.1128/aac.00393-08
Acinetobacter baumannii Acinetobacter baumannii MIC 128.0 ug.mL-1 10.1128/aac.00393-08
Acinetobacter baumannii Acinetobacter baumannii MIC 256.0 ug.mL-1 10.1128/aac.00050-10
Acinetobacter baumannii Acinetobacter baumannii MIC 256.0 ug.mL-1 10.1128/aac.00861-09
Acinetobacter baumannii Acinetobacter baumannii MIC nan None 10.1128/aac.00393-08
Acinetobacter genomosp. 3 ADC-14 protein Kcat 0.01 /s 10.1128/aac.00485-08
Acinetobacter genomosp. 3 ADC-14 protein Kcat/Km 529.41 /mM/s 10.1128/aac.00485-08
Acinetobacter genomosp. 3 ADC-14 protein Km 20.0 nM 10.1128/aac.00485-08
Acinetobacter genomosp. 3 ADC-16 protein Kcat 0.62 /s 10.1128/aac.00485-08
Acinetobacter genomosp. 3 ADC-16 protein Kcat/Km 2342.1 /mM/s 10.1128/aac.00485-08
Acinetobacter genomosp. 3 ADC-16 protein Km 270.0 nM 10.1128/aac.00485-08
Acinetobacter genomosp. 3 ADC-18 protein Kcat 0.48 /s 10.1128/aac.00485-08
Acinetobacter genomosp. 3 ADC-18 protein Kcat/Km 1791.05 /mM/s 10.1128/aac.00485-08
Acinetobacter genomosp. 3 ADC-18 protein Km 270.0 nM 10.1128/aac.00485-08
Acinetobacter pittii Acinetobacter pittii MIC 16.0 ug.mL-1 10.1128/aac.00485-08
Acinetobacter pittii Acinetobacter pittii MIC 24.0 ug.mL-1 10.1128/aac.00485-08
Acinetobacter pittii Acinetobacter pittii MIC 32.0 ug.mL-1 10.1128/aac.00485-08
Acinetobacter pittii Acinetobacter pittii MIC 48.0 ug.mL-1 10.1128/aac.00485-08
Acinetobacter pittii Acinetobacter pittii MIC 64.0 ug.mL-1 10.1128/aac.00485-08
Aeromonas caviae IMP-19 Kcat 16.4 /s 10.1128/aac.01462-06
Aeromonas caviae IMP-19 Kcat/Km 0.17 None 10.1128/aac.01462-06
Aeromonas caviae IMP-19 Km 95000.0 nM 10.1128/aac.01462-06
Aeromonas hydrophila Aeromonas hydrophila MIC 500.0 ug.mL-1 10.1016/j.ejmech.2015.07.002
Alcaligenes Alcaligenes MBC 100.0 ug ml-1 10.1021/jm00388a003
Alcaligenes Alcaligenes MIC 50.0 ug.mL-1 10.1021/jm00388a003
Bacillus Bacillus MBC 35.36 ug ml-1 10.1021/jm00388a003
Bacillus Bacillus MIC 35.36 ug.mL-1 10.1021/jm00388a003
Bacillus cereus Bacillus cereus MBC nan None 10.1007/s00044-012-0248-y
Bacillus cereus Bacillus cereus MBC nan None 10.1016/j.ejmech.2011.10.055
Bacillus cereus Bacillus cereus MIC 31.25 ug.mL-1 10.1007/s00044-012-0248-y
Bacillus cereus Bacillus cereus MIC 31.25 ug.mL-1 10.1016/j.ejmech.2011.10.055
Bacillus cereus Bacillus cereus MIC 62.5 ug.mL-1 10.1007/s00044-012-0302-9
Bacillus clausii Beta-lactamase Activity 2.0 None 10.1128/aac.00537-07
Bacillus clausii Beta-lactamase Kcat 15.0 /s 10.1128/aac.00537-07
Bacillus clausii Beta-lactamase Kcat/Km 0.1 /uM/s 10.1128/aac.00537-07
Bacillus clausii Beta-lactamase Km 105000.0 nM 10.1128/aac.00537-07
Bacillus spizizenii Bacillus spizizenii MIC 0.49 ug.mL-1 10.1007/s00044-012-0302-9
Bacillus subtilis Bacillus subtilis Activity nan None 10.1039/c2md20127e
Bacillus subtilis Bacillus subtilis MBC nan None 10.1007/s00044-012-0248-y
Bacillus subtilis Bacillus subtilis MBC nan None 10.1016/j.ejmech.2011.10.055
Bacillus subtilis Bacillus subtilis MIC 15.63 ug.mL-1 10.1007/s00044-012-0248-y
Bacillus subtilis Bacillus subtilis MIC 15.63 ug.mL-1 10.1016/j.ejmech.2011.10.055
Bacillus subtilis Bacillus subtilis MIC 20000.0 nM 10.1039/c2md20127e
Bacillus subtilis Bacillus subtilis Ratio 0.306 None 10.1039/c2md20127e
Brachyspira pilosicoli Class D beta-lactamase Kcat nan None 10.1128/aac.00684-07
Burkholderia cenocepacia Burkholderia cenocepacia MIC 16.0 ug.mL-1 10.1128/aac.00946-08
Burkholderia cenocepacia Burkholderia cenocepacia MIC 32.0 ug.mL-1 10.1128/aac.00946-08
Burkholderia cenocepacia Burkholderia cenocepacia MIC 512.0 ug.mL-1 10.1128/aac.00946-08
Burkholderia cenocepacia PenB class A beta-lactamase Kcat 170.0 /s 10.1128/aac.00946-08
Burkholderia cenocepacia PenB class A beta-lactamase Kcat/Km 2100.0 /uM/s 10.1128/aac.00946-08
Burkholderia cenocepacia PenB class A beta-lactamase Km 80000.0 nM 10.1128/aac.00946-08
Campylobacter coli Campylobacter coli MIC 64.0 ug.mL-1 10.1128/aac.01655-08
Campylobacter coli Campylobacter coli MIC50 128.0 ug.mL-1 10.1128/aac.01655-08
Campylobacter coli Campylobacter coli MIC90 256.0 ug.mL-1 10.1128/aac.01655-08
Campylobacter jejuni Campylobacter jejuni MIC 1.0 ug.mL-1 10.1128/aac.01655-08
Campylobacter jejuni Campylobacter jejuni MIC 32.0 ug.mL-1 10.1128/aac.01655-08
Campylobacter jejuni Campylobacter jejuni MIC 64.0 ug.mL-1 10.1128/aac.01655-08
Campylobacter jejuni Campylobacter jejuni MIC 128.0 ug.mL-1 10.1128/aac.01655-08
Campylobacter jejuni Campylobacter jejuni MIC 256.0 ug.mL-1 10.1128/aac.01655-08
Campylobacter jejuni Campylobacter jejuni MIC50 128.0 ug.mL-1 10.1128/aac.01655-08
Campylobacter jejuni Campylobacter jejuni MIC90 128.0 ug.mL-1 10.1128/aac.01655-08
Caulobacter vibrioides Metallo-beta-lactamase Kcat/Km 1.4 10'4/M/s 10.1128/aac.01062-07
Chryseobacterium indologenes Chryseobacterium indologenes MIC 64.0 ug.mL-1 10.1128/aac.01607-08
Chryseobacterium indologenes Metallo-beta-lactamase IND-6 Kcat 75.0 /s 10.1128/aac.01607-08
Chryseobacterium indologenes Metallo-beta-lactamase IND-6 Kcat/Km 3.3 10'6/M/s 10.1128/aac.01607-08
Chryseobacterium indologenes Metallo-beta-lactamase IND-6 Km 23000.0 nM 10.1128/aac.01607-08
Citrobacter freundii Citrobacter freundii MIC 512.0 ug.mL-1 10.1128/aac.01337-07
Citrobacter freundii PER-2 beta-lactamase Activity 45.0 % 10.1128/aac.01395-06
Citrobacter freundii PER-2 beta-lactamase Kcat 6.0 /s 10.1128/aac.01395-06
Citrobacter freundii PER-2 beta-lactamase Kcat/Km 0.3 /uM/s 10.1128/aac.01395-06
Citrobacter freundii PER-2 beta-lactamase Km 21000.0 nM 10.1128/aac.01395-06
Citrobacter gillenii Gil1 Kcat 2.0 /s 10.1128/aac.01152-06
Citrobacter gillenii Gil1 Kcat/Km 23.0 /mM/s 10.1128/aac.01152-06
Citrobacter gillenii Gil1 Km 88000.0 nM 10.1128/aac.01152-06
Citrobacter gillenii Gil1 Ratio 0.4 None 10.1128/aac.01152-06
Corynebacterium amycolatum Corynebacterium amycolatum MIC 0.125 ug.mL-1 10.1128/aac.01129-07
Corynebacterium amycolatum Corynebacterium amycolatum MIC50 0.5 ug.mL-1 10.1128/aac.01129-07
Corynebacterium amycolatum Corynebacterium amycolatum MIC90 2.0 ug.mL-1 10.1128/aac.01129-07
Corynebacterium jeikeium Corynebacterium jeikeium MIC 2.0 ug.mL-1 10.1128/aac.01129-07
Corynebacterium jeikeium Corynebacterium jeikeium MIC50 32.0 ug.mL-1 10.1128/aac.01129-07
Corynebacterium jeikeium Corynebacterium jeikeium MIC90 32.0 ug.mL-1 10.1128/aac.01129-07
Corynebacterium minutissimum Corynebacterium minutissimum MIC 0.25 ug.mL-1 10.1128/aac.01129-07
Corynebacterium minutissimum Corynebacterium minutissimum MIC50 0.5 ug.mL-1 10.1128/aac.01129-07
Corynebacterium pseudodiphtheriticum Corynebacterium pseudodiphtheriticum MIC 0.03 ug.mL-1 10.1128/aac.01129-07
Corynebacterium pseudodiphtheriticum Corynebacterium pseudodiphtheriticum MIC50 0.06 ug.mL-1 10.1128/aac.01129-07
Corynebacterium pseudodiphtheriticum Corynebacterium pseudodiphtheriticum MIC90 0.125 ug.mL-1 10.1128/aac.01129-07
Corynebacterium striatum Corynebacterium striatum MIC 0.125 ug.mL-1 10.1128/aac.01129-07
Corynebacterium striatum Corynebacterium striatum MIC50 1.0 ug.mL-1 10.1128/aac.01129-07
Corynebacterium striatum Corynebacterium striatum MIC90 2.0 ug.mL-1 10.1128/aac.01129-07
Corynebacterium urealyticum Corynebacterium urealyticum MIC 4.0 ug.mL-1 10.1128/aac.01129-07
Corynebacterium urealyticum Corynebacterium urealyticum MIC50 32.0 ug.mL-1 10.1128/aac.01129-07
Corynebacterium urealyticum Corynebacterium urealyticum MIC90 32.0 ug.mL-1 10.1128/aac.01129-07
Corynebacterium xerosis Corynebacterium xerosis MIC 0.125 ug.mL-1 10.1128/aac.01129-07
Corynebacterium xerosis Corynebacterium xerosis MIC50 2.0 ug.mL-1 10.1128/aac.01129-07
Elizabethkingia meningoseptica GOB-1 metallo-beta-lactamase Kcat/Km 9.8 10'5/M/s 10.1128/aac.01062-07
Enterobacter Enterobacter MBC 25.0 ug ml-1 10.1021/jm00388a003
Enterobacter Enterobacter MIC 7.01 ug.mL-1 10.1021/jm00388a003
Enterobacter cloacae Enterobacter cloacae MIC 48.0 ug.mL-1 10.1128/aac.00072-07
Enterobacter cloacae Enterobacter cloacae MIC 256.0 ug.mL-1 10.1128/aac.00072-07
Enterobacter cloacae Enterobacter cloacae MIC 256.0 ug.mL-1 10.1128/aac.01082-06
Enterobacteriaceae Enterobacteriaceae Activity 21.9 % 10.1128/aac.00044-07
Enterobacteriaceae Enterobacteriaceae Activity 46.9 % 10.1128/aac.00044-07
Enterococcus faecalis Enterococcus faecalis MIC 128.0 ug.mL-1 10.1016/j.ejmech.2017.09.048
Enterococcus faecium Enterococcus faecium MIC 128.0 ug.mL-1 10.1016/j.ejmech.2017.09.048
Escherichia coli Beta-lactamase SHV-11 Kcat 0.05 /s 10.1128/aac.00387-08
Escherichia coli Beta-lactamase SHV-11 Kcat/Km 0.25 /uM/s 10.1128/aac.00387-08
Escherichia coli Beta-lactamase SHV-11 Km 200000.0 nM 10.1128/aac.00387-08
Escherichia coli BlaVIM-1 Kcat 324.0 /s 10.1128/aac.00017-09
Escherichia coli BlaVIM-1 Kcat/Km 7.7 /s/microM 10.1128/aac.00017-09
Escherichia coli Escherichia coli Activity 0.0 % 10.1128/aac.00551-10
Escherichia coli Escherichia coli Activity 1.1 % 10.1128/aac.00551-10
Escherichia coli Escherichia coli Activity 100.0 % 10.1128/aac.01412-06
Escherichia coli Escherichia coli Activity nan None 10.1021/acs.jmedchem.0c00040
Escherichia coli Escherichia coli Activity nan None 10.1128/aac.00614-07
Escherichia coli Escherichia coli ED50 4.8 mg.kg-1 10.1021/jm00388a003
Escherichia coli Escherichia coli MBC 4.42 ug ml-1 10.1021/jm00388a003
Escherichia coli Escherichia coli MIC 0.125 ug.mL-1 10.1128/aac.01155-08
Escherichia coli Escherichia coli MIC 0.25 ug.mL-1 10.1128/aac.01155-08
Escherichia coli Escherichia coli MIC 0.5 ug.mL-1 10.1128/aac.00791-09
Escherichia coli Escherichia coli MIC 0.5 ug.mL-1 10.1128/aac.00961-09
Escherichia coli Escherichia coli MIC 0.5 ug.mL-1 10.1128/aac.01052-07
Escherichia coli Escherichia coli MIC 1.0 ug.mL-1 10.1128/aac.00389-07
Escherichia coli Escherichia coli MIC 1.0 ug.mL-1 10.1128/aac.00896-08
Escherichia coli Escherichia coli MIC 1.0 ug.mL-1 10.1128/aac.01439-06
Escherichia coli Escherichia coli MIC 1.0 ug.mL-1 10.1128/aac.01762-09
Escherichia coli Escherichia coli MIC 1.024 ug.mL-1 10.1016/j.ejmech.2021.113975
Escherichia coli Escherichia coli MIC 1.5 ug.mL-1 10.1128/aac.00485-08
Escherichia coli Escherichia coli MIC 1.56 ug.mL-1 10.1016/j.ejmech.2012.03.008
Escherichia coli Escherichia coli MIC 2.0 ug.mL-1 10.1128/aac.00050-10
Escherichia coli Escherichia coli MIC 2.0 ug.mL-1 10.1128/aac.00219-09
Escherichia coli Escherichia coli MIC 2.0 ug.mL-1 10.1128/aac.00310-09
Escherichia coli Escherichia coli MIC 2.0 ug.mL-1 10.1128/aac.00458-09
Escherichia coli Escherichia coli MIC 2.0 ug.mL-1 10.1128/aac.00461-09
Escherichia coli Escherichia coli MIC 2.0 ug.mL-1 10.1128/aac.00859-09
Escherichia coli Escherichia coli MIC 2.0 ug.mL-1 10.1128/aac.00912-08
Escherichia coli Escherichia coli MIC 2.0 ug.mL-1 10.1128/aac.01052-07
Escherichia coli Escherichia coli MIC 2.0 ug.mL-1 10.1128/aac.01082-06
Escherichia coli Escherichia coli MIC 2.0 ug.mL-1 10.1128/aac.01152-06
Escherichia coli Escherichia coli MIC 2.0 ug.mL-1 10.1128/aac.01164-08
Escherichia coli Escherichia coli MIC 2.0 ug.mL-1 10.1128/aac.01284-08
Escherichia coli Escherichia coli MIC 2.0 ug.mL-1 10.1128/aac.01337-07
Escherichia coli Escherichia coli MIC 2.0 ug.mL-1 10.1128/aac.01463-07
Escherichia coli Escherichia coli MIC 2.0 ug.mL-1 10.1128/aac.01561-09
Escherichia coli Escherichia coli MIC 2.0 ug.mL-1 10.1128/aac.01600-06
Escherichia coli Escherichia coli MIC 2.0 ug.mL-1 10.1128/aac.01607-08
Escherichia coli Escherichia coli MIC 2.2 ug.mL-1 10.1021/jm00388a003
Escherichia coli Escherichia coli MIC 4.0 ug.mL-1 10.1128/aac.00017-09
Escherichia coli Escherichia coli MIC 4.0 ug.mL-1 10.1128/aac.00393-08
Escherichia coli Escherichia coli MIC 4.0 ug.mL-1 10.1128/aac.00458-09
Escherichia coli Escherichia coli MIC 4.0 ug.mL-1 10.1128/aac.00461-09
Escherichia coli Escherichia coli MIC 4.0 ug.mL-1 10.1128/aac.00485-08
Escherichia coli Escherichia coli MIC 4.0 ug.mL-1 10.1128/aac.00614-07
Escherichia coli Escherichia coli MIC 4.0 ug.mL-1 10.1128/aac.00858-10
Escherichia coli Escherichia coli MIC 4.0 ug.mL-1 10.1128/aac.01025-07
Escherichia coli Escherichia coli MIC 4.0 ug.mL-1 10.1128/aac.01052-07
Escherichia coli Escherichia coli MIC 4.0 ug.mL-1 10.1128/aac.01058-06
Escherichia coli Escherichia coli MIC 4.0 ug.mL-1 10.1128/aac.01062-07
Escherichia coli Escherichia coli MIC 4.0 ug.mL-1 10.1128/aac.01164-08
Escherichia coli Escherichia coli MIC 4.0 ug.mL-1 10.1128/aac.01247-07
Escherichia coli Escherichia coli MIC 4.0 ug.mL-1 10.1128/aac.01381-07
Escherichia coli Escherichia coli MIC 4.0 ug.mL-1 10.1128/aac.01412-06
Escherichia coli Escherichia coli MIC 4.0 ug.mL-1 10.1128/aac.01463-07
Escherichia coli Escherichia coli MIC 4.0 ug.mL-1 10.1128/aac.01600-06
Escherichia coli Escherichia coli MIC 6.0 ug.mL-1 10.1128/aac.00133-09
Escherichia coli Escherichia coli MIC 8.0 ug.mL-1 10.1128/aac.00310-09
Escherichia coli Escherichia coli MIC 8.0 ug.mL-1 10.1128/aac.00614-07
Escherichia coli Escherichia coli MIC 8.0 ug.mL-1 10.1128/aac.00774-09
Escherichia coli Escherichia coli MIC 8.0 ug.mL-1 10.1128/aac.00912-08
Escherichia coli Escherichia coli MIC 8.0 ug.mL-1 10.1128/aac.00946-08
Escherichia coli Escherichia coli MIC 8.0 ug.mL-1 10.1128/aac.01052-07
Escherichia coli Escherichia coli MIC 8.0 ug.mL-1 10.1128/aac.01058-06
Escherichia coli Escherichia coli MIC 8.0 ug.mL-1 10.1128/aac.01082-06
Escherichia coli Escherichia coli MIC 8.0 ug.mL-1 10.1128/aac.01152-06
Escherichia coli Escherichia coli MIC 8.0 ug.mL-1 10.1128/aac.01247-07
Escherichia coli Escherichia coli MIC 8.0 ug.mL-1 10.1128/aac.01336-09
Escherichia coli Escherichia coli MIC 8.0 ug.mL-1 10.1128/aac.01337-07
Escherichia coli Escherichia coli MIC 8.0 ug.mL-1 10.1128/aac.01381-07
Escherichia coli Escherichia coli MIC 8.0 ug.mL-1 10.1128/aac.01400-08
Escherichia coli Escherichia coli MIC 16.0 ug.mL-1 10.1128/aac.00158-08
Escherichia coli Escherichia coli MIC 16.0 ug.mL-1 10.1128/aac.00310-09
Escherichia coli Escherichia coli MIC 16.0 ug.mL-1 10.1128/aac.00896-08
Escherichia coli Escherichia coli MIC 16.0 ug.mL-1 10.1128/aac.00946-08
Escherichia coli Escherichia coli MIC 16.0 ug.mL-1 10.1128/aac.00961-09
Escherichia coli Escherichia coli MIC 16.0 ug.mL-1 10.1128/aac.01058-06
Escherichia coli Escherichia coli MIC 32.0 ug.mL-1 10.1128/aac.00485-08
Escherichia coli Escherichia coli MIC 32.0 ug.mL-1 10.1128/aac.00859-09
Escherichia coli Escherichia coli MIC 32.0 ug.mL-1 10.1128/aac.00912-08
Escherichia coli Escherichia coli MIC 32.0 ug.mL-1 10.1128/aac.01247-07
Escherichia coli Escherichia coli MIC 32.0 ug.mL-1 10.1128/aac.01439-06
Escherichia coli Escherichia coli MIC 32.0 ug.mL-1 10.1128/aac.01607-08
Escherichia coli Escherichia coli MIC 32.0 ug.mL-1 10.1128/aac.01658-07
Escherichia coli Escherichia coli MIC 32.0 ug.mL-1 10.1128/aac.01762-09
Escherichia coli Escherichia coli MIC 48.0 ug.mL-1 10.1128/aac.00485-08
Escherichia coli Escherichia coli MIC 64.0 ug.mL-1 10.1128/aac.00050-10
Escherichia coli Escherichia coli MIC 64.0 ug.mL-1 10.1128/aac.00133-09
Escherichia coli Escherichia coli MIC 64.0 ug.mL-1 10.1128/aac.00158-08
Escherichia coli Escherichia coli MIC 64.0 ug.mL-1 10.1128/aac.00485-08
Escherichia coli Escherichia coli MIC 64.0 ug.mL-1 10.1128/aac.00858-10
Escherichia coli Escherichia coli MIC 64.0 ug.mL-1 10.1128/aac.01025-07
Escherichia coli Escherichia coli MIC 64.0 ug.mL-1 10.1128/aac.01155-08
Escherichia coli Escherichia coli MIC 64.0 ug.mL-1 10.1128/aac.01658-07
Escherichia coli Escherichia coli MIC 96.0 ug.mL-1 10.1128/aac.00133-09
Escherichia coli Escherichia coli MIC 96.0 ug.mL-1 10.1128/aac.00485-08
Escherichia coli Escherichia coli MIC 96.0 ug.mL-1 10.1128/aac.00912-08
Escherichia coli Escherichia coli MIC 128.0 ug.mL-1 10.1128/aac.00050-10
Escherichia coli Escherichia coli MIC 128.0 ug.mL-1 10.1128/aac.00133-09
Escherichia coli Escherichia coli MIC 128.0 ug.mL-1 10.1128/aac.00389-07
Escherichia coli Escherichia coli MIC 128.0 ug.mL-1 10.1128/aac.00858-10
Escherichia coli Escherichia coli MIC 128.0 ug.mL-1 10.1128/aac.00859-09
Escherichia coli Escherichia coli MIC 128.0 ug.mL-1 10.1128/aac.00912-08
Escherichia coli Escherichia coli MIC 128.0 ug.mL-1 10.1128/aac.01025-07
Escherichia coli Escherichia coli MIC 128.0 ug.mL-1 10.1128/aac.01155-08
Escherichia coli Escherichia coli MIC 128.0 ug.mL-1 10.1128/aac.01247-07
Escherichia coli Escherichia coli MIC 128.0 ug.mL-1 10.1128/aac.01658-07
Escherichia coli Escherichia coli MIC 128.0 ug.mL-1 10.1128/aac.01762-09
Escherichia coli Escherichia coli MIC 256.0 ug.mL-1 10.1128/aac.00050-10
Escherichia coli Escherichia coli MIC 256.0 ug.mL-1 10.1128/aac.00133-09
Escherichia coli Escherichia coli MIC 256.0 ug.mL-1 10.1128/aac.00461-09
Escherichia coli Escherichia coli MIC 256.0 ug.mL-1 10.1128/aac.00774-09
Escherichia coli Escherichia coli MIC 256.0 ug.mL-1 10.1128/aac.00791-09
Escherichia coli Escherichia coli MIC 256.0 ug.mL-1 10.1128/aac.00912-08
Escherichia coli Escherichia coli MIC 256.0 ug.mL-1 10.1128/aac.01062-07
Escherichia coli Escherichia coli MIC 256.0 ug.mL-1 10.1128/aac.01284-08
Escherichia coli Escherichia coli MIC 256.0 ug.mL-1 10.1128/aac.01336-09
Escherichia coli Escherichia coli MIC 256.0 ug.mL-1 10.1128/aac.01412-06
Escherichia coli Escherichia coli MIC 256.0 ug.mL-1 10.1128/aac.01658-07
Escherichia coli Escherichia coli MIC 256.0 ug.mL-1 10.1128/aac.01762-09
Escherichia coli Escherichia coli MIC 500.0 ug.mL-1 10.1016/j.ejmech.2015.07.002
Escherichia coli Escherichia coli MIC 500.0 ug.mL-1 10.1128/aac.00537-07
Escherichia coli Escherichia coli MIC 512.0 ug.mL-1 10.1128/aac.00017-09
Escherichia coli Escherichia coli MIC 512.0 ug.mL-1 10.1128/aac.00219-09
Escherichia coli Escherichia coli MIC 512.0 ug.mL-1 10.1128/aac.00389-07
Escherichia coli Escherichia coli MIC 512.0 ug.mL-1 10.1128/aac.00458-09
Escherichia coli Escherichia coli MIC 512.0 ug.mL-1 10.1128/aac.00461-09
Escherichia coli Escherichia coli MIC 512.0 ug.mL-1 10.1128/aac.01337-07
Escherichia coli Escherichia coli MIC 512.0 ug.mL-1 10.1128/aac.01561-09
Escherichia coli Escherichia coli MIC 512.0 ug.mL-1 10.1128/aac.01762-09
Escherichia coli Escherichia coli MIC 1024.0 ug.mL-1 10.1128/aac.00017-09
Escherichia coli Escherichia coli MIC 1024.0 ug.mL-1 10.1128/aac.01058-06
Escherichia coli Escherichia coli MIC 2000.0 ug.mL-1 10.1128/aac.00537-07
Escherichia coli Escherichia coli MIC 8000.0 ug.mL-1 10.1128/aac.00537-07
Escherichia coli Escherichia coli MIC 16000.0 ug.mL-1 10.1128/aac.00537-07
Escherichia coli Escherichia coli MIC nan None 10.1128/aac.00393-08
Escherichia coli Escherichia coli MIC50 16.0 ug.mL-1 10.1128/aac.01412-06
Escherichia coli Escherichia coli MIC90 16.0 ug.mL-1 10.1128/aac.01412-06
Escherichia coli Escherichia coli Ratio 8.0 None 10.1016/j.ejmech.2012.03.008
Escherichia coli Escherichia coli Ratio 16.0 None 10.1016/j.ejmech.2012.03.008
Escherichia coli Metallo-beta-lactamase Kcat 8.0 /s 10.1128/aac.01336-09
Escherichia coli Metallo-beta-lactamase Kcat 12.0 /s 10.1128/aac.01336-09
Escherichia coli Metallo-beta-lactamase Kcat 12.1 /s 10.1128/aac.00017-09
Escherichia coli Metallo-beta-lactamase Kcat 15.0 /s 10.1128/aac.01336-09
Escherichia coli Metallo-beta-lactamase Kcat/Km 0.4 uM/hr 10.1128/aac.01336-09
Escherichia coli Metallo-beta-lactamase Kcat/Km 0.4 /uM/s 10.1128/aac.01336-09
Escherichia coli Metallo-beta-lactamase Kcat/Km 0.55 /s/microM 10.1128/aac.00017-09
Escherichia coli Metallo-beta-lactamase Kcat/Km 0.65 /uM/s 10.1128/aac.01336-09
Escherichia coli Metallo-beta-lactamase Kcat/Km 0.67 /uM/s 10.1128/aac.01336-09
Escherichia coli Metallo-beta-lactamase Km 18000.0 nM 10.1128/aac.01336-09
Escherichia coli Metallo-beta-lactamase Km 20000.0 nM 10.1128/aac.01336-09
Escherichia coli Metallo-beta-lactamase Km 23000.0 nM 10.1128/aac.01336-09
Flavobacterium meningosepticum Carbapenem-hydrolyzing beta-lactamase BlaB-1 Kcat/Km 1.0 10'6/M/s 10.1128/aac.01607-08
Fluoribacter gormanii FEZ-1 protein Kcat/Km 6.6 10'6/M/s 10.1128/aac.01062-07
Haemophilus influenzae Haemophilus influenzae Activity 0.0 % 10.1128/aac.00354-07
Haemophilus influenzae Haemophilus influenzae Activity 0.1 % 10.1128/aac.01548-09
Haemophilus influenzae Haemophilus influenzae Activity 0.2 % 10.1128/aac.00971-07
Haemophilus influenzae Haemophilus influenzae Activity 0.3 % 10.1128/aac.00971-07
Haemophilus influenzae Haemophilus influenzae Activity 0.7 % 10.1128/aac.00971-07
Haemophilus influenzae Haemophilus influenzae Activity 1.2 % 10.1128/aac.00422-07
Haemophilus influenzae Haemophilus influenzae Activity 1.4 % 10.1128/aac.00422-07
Haemophilus influenzae Haemophilus influenzae Activity 2.0 % 10.1128/aac.00354-07
Haemophilus influenzae Haemophilus influenzae Activity 19.0 % 10.1128/aac.00402-08
Haemophilus influenzae Haemophilus influenzae Activity 20.0 % 10.1128/aac.00402-08
Haemophilus influenzae Haemophilus influenzae Activity 21.4 % 10.1128/aac.00422-07
Haemophilus influenzae Haemophilus influenzae Activity 45.4 % 10.1128/aac.00402-08
Haemophilus influenzae Haemophilus influenzae Activity 48.8 % 10.1128/aac.00402-08
Haemophilus influenzae Haemophilus influenzae Activity 66.3 % 10.1128/aac.00422-07
Haemophilus influenzae Haemophilus influenzae Activity 91.4 % 10.1128/aac.01548-09
Haemophilus influenzae Haemophilus influenzae Activity 94.6 % 10.1128/aac.00422-07
Haemophilus influenzae Haemophilus influenzae Activity 96.3 % 10.1128/aac.00971-07
Haemophilus influenzae Haemophilus influenzae Activity 97.6 % 10.1128/aac.00971-07
Haemophilus influenzae Haemophilus influenzae Activity 97.7 % 10.1128/aac.00422-07
Haemophilus influenzae Haemophilus influenzae Activity 98.0 % 10.1128/aac.00354-07
Haemophilus influenzae Haemophilus influenzae Activity 98.0 % 10.1128/aac.00971-07
Haemophilus influenzae Haemophilus influenzae Activity 99.3 % 10.1128/aac.01548-09
Haemophilus influenzae Haemophilus influenzae Activity 100.0 % 10.1128/aac.00354-07
Haemophilus influenzae Haemophilus influenzae MIC 0.12 ug.mL-1 10.1128/aac.00354-07
Haemophilus influenzae Haemophilus influenzae MIC 0.25 ug.mL-1 10.1128/aac.00354-07
Haemophilus influenzae Haemophilus influenzae MIC 0.5 ug.mL-1 10.1016/j.bmc.2012.02.052
Haemophilus influenzae Haemophilus influenzae MIC 0.5 ug.mL-1 10.1016/j.bmc.2014.05.058
Haemophilus influenzae Haemophilus influenzae MIC 0.5 ug.mL-1 10.1021/jm300395d
Haemophilus influenzae Haemophilus influenzae MIC 0.5 ug.mL-1 10.1128/aac.00190-07
Haemophilus influenzae Haemophilus influenzae MIC 0.5 ug.mL-1 10.1128/aac.00354-07
Haemophilus influenzae Haemophilus influenzae MIC 0.5 ug.mL-1 10.1128/aac.00936-07
Haemophilus influenzae Haemophilus influenzae MIC 0.5 ug.mL-1 10.1128/aac.01489-09
Haemophilus influenzae Haemophilus influenzae MIC 2.0 ug.mL-1 10.1128/aac.00354-07
Haemophilus influenzae Haemophilus influenzae MIC 2.0 ug.mL-1 10.1128/aac.00936-07
Haemophilus influenzae Haemophilus influenzae MIC 2.0 ug.mL-1 10.1128/aac.00966-09
Haemophilus influenzae Haemophilus influenzae MIC 4.0 ug.mL-1 10.1128/aac.00966-09
Haemophilus influenzae Haemophilus influenzae MIC 4.0 ug.mL-1 10.1128/aac.01489-09
Haemophilus influenzae Haemophilus influenzae MIC 6.0 ug.mL-1 10.1128/aac.00966-09
Haemophilus influenzae Haemophilus influenzae MIC 6.5 ug.mL-1 10.1128/aac.00966-09
Haemophilus influenzae Haemophilus influenzae MIC 8.0 ug.mL-1 10.1128/aac.00966-09
Haemophilus influenzae Haemophilus influenzae MIC 9.3 ug.mL-1 10.1128/aac.00966-09
Haemophilus influenzae Haemophilus influenzae MIC 11.4 ug.mL-1 10.1128/aac.00966-09
Haemophilus influenzae Haemophilus influenzae MIC 13.3 ug.mL-1 10.1128/aac.00966-09
Haemophilus influenzae Haemophilus influenzae MIC 32.0 ug.mL-1 10.1128/aac.00966-09
Haemophilus influenzae Haemophilus influenzae MIC50 0.5 ug.mL-1 10.1128/aac.00354-07
Haemophilus influenzae Haemophilus influenzae MIC50 0.5 ug.mL-1 10.1128/aac.00960-06
Haemophilus influenzae Haemophilus influenzae MIC50 0.5 ug.mL-1 10.1128/aac.01548-09
Haemophilus influenzae Haemophilus influenzae MIC50 1.0 ug.mL-1 10.1128/aac.00354-07
Haemophilus influenzae Haemophilus influenzae MIC50 1.0 ug.mL-1 10.1128/aac.00402-08
Haemophilus influenzae Haemophilus influenzae MIC50 1.0 ug.mL-1 10.1128/aac.00422-07
Haemophilus influenzae Haemophilus influenzae MIC50 1.0 ug.mL-1 10.1128/aac.00960-06
Haemophilus influenzae Haemophilus influenzae MIC50 1.0 ug.mL-1 10.1128/aac.00971-07
Haemophilus influenzae Haemophilus influenzae MIC50 2.0 ug.mL-1 10.1128/aac.00354-07
Haemophilus influenzae Haemophilus influenzae MIC50 2.0 ug.mL-1 10.1128/aac.00402-08
Haemophilus influenzae Haemophilus influenzae MIC50 2.0 ug.mL-1 10.1128/aac.00422-07
Haemophilus influenzae Haemophilus influenzae MIC50 2.0 ug.mL-1 10.1128/aac.00966-09
Haemophilus influenzae Haemophilus influenzae MIC50 4.0 ug.mL-1 10.1128/aac.00354-07
Haemophilus influenzae Haemophilus influenzae MIC50 4.0 ug.mL-1 10.1128/aac.00402-08
Haemophilus influenzae Haemophilus influenzae MIC50 8.0 ug.mL-1 10.1128/aac.00966-09
Haemophilus influenzae Haemophilus influenzae MIC50 64.0 ug.mL-1 10.1128/aac.00422-07
Haemophilus influenzae Haemophilus influenzae MIC90 1.0 ug.mL-1 10.1128/aac.00354-07
Haemophilus influenzae Haemophilus influenzae MIC90 1.0 ug.mL-1 10.1128/aac.00960-06
Haemophilus influenzae Haemophilus influenzae MIC90 1.0 ug.mL-1 10.1128/aac.01548-09
Haemophilus influenzae Haemophilus influenzae MIC90 2.0 ug.mL-1 10.1128/aac.00354-07
Haemophilus influenzae Haemophilus influenzae MIC90 2.0 ug.mL-1 10.1128/aac.00422-07
Haemophilus influenzae Haemophilus influenzae MIC90 2.0 ug.mL-1 10.1128/aac.00971-07
Haemophilus influenzae Haemophilus influenzae MIC90 4.0 ug.mL-1 10.1128/aac.00354-07
Haemophilus influenzae Haemophilus influenzae MIC90 8.0 ug.mL-1 10.1128/aac.00354-07
Haemophilus influenzae Haemophilus influenzae MIC90 8.0 ug.mL-1 10.1128/aac.00402-08
Haemophilus influenzae Haemophilus influenzae MIC90 8.0 ug.mL-1 10.1128/aac.00960-06
Haemophilus influenzae Haemophilus influenzae MIC90 8.0 ug.mL-1 10.1128/aac.00966-09
Haemophilus influenzae Haemophilus influenzae MIC90 16.0 ug.mL-1 10.1128/aac.00402-08
Haemophilus influenzae Haemophilus influenzae MIC90 16.0 ug.mL-1 10.1128/aac.00422-07
Haemophilus influenzae Haemophilus influenzae MIC90 16.0 ug.mL-1 10.1128/aac.00966-09
Haemophilus influenzae Haemophilus influenzae MIC90 32.0 ug.mL-1 10.1128/aac.00966-09
Haemophilus influenzae Haemophilus influenzae MIC90 128.0 ug.mL-1 10.1128/aac.00422-07
Haemophilus influenzae Haemophilus influenzae MIC90 256.0 ug.mL-1 10.1128/aac.00960-06
Homo sapiens Adenosine A1 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Adenosine A2a receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Adenosine A3 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-1a adrenergic receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-2a adrenergic receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-2b adrenergic receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-2c adrenergic receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Beta-1 adrenergic receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Beta-2 adrenergic receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Bile salt export pump AC50 300000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Bradykinin B2 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Caco-2 logPapp -6.42 None 10.1016/j.bmc.2011.03.011
Homo sapiens Canalicular multispecific organic anion transporter 1 Inhibition nan % 10.1124/dmd.111.041731
Homo sapiens Canalicular multispecific organic anion transporter 2 Inhibition nan % 10.1124/dmd.111.041731
Homo sapiens Cannabinoid CB1 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Cholecystokinin A receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Cholecystokinin B receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Cyclooxygenase-2 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Delta opioid receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine D1 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine D2 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine D3 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine transporter AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Endothelin receptor ET-A AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Equilibrative nucleoside transporter 1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Estrogen receptor alpha AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Gamma-aminobutyric acid receptor subunit alpha-1/alpha-2/beta-2/gamma-2 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Ghrelin receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Glucocorticoid receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens HERG AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Histamine H1 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Histamine H2 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Histamine H3 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Homo sapiens Activity 1.0 % 10.1016/j.ejmech.2009.11.034
Homo sapiens Homo sapiens CL 0.1 mL.min-1.kg-1 10.1021/jm901371v
Homo sapiens Homo sapiens CL 2.2 mL.min-1.kg-1 10.1021/jm900403j
Homo sapiens Homo sapiens CL 2.2 mL.min-1.kg-1 10.1021/jm901371v
Homo sapiens Homo sapiens CL_renal 2.1 mL.min-1.kg-1 10.1021/jm901371v
Homo sapiens Homo sapiens CL_renal 2.11 mL.min-1.kg-1 10.1021/jm900403j
Homo sapiens Homo sapiens Cmax 61264.4 nM 10.1128/aac.01605-07
Homo sapiens Homo sapiens DILI_Concern nan None 10.1016/j.drudis.2016.02.015
Homo sapiens Homo sapiens DILI_severity_class 5.0 None 10.1016/j.drudis.2016.02.015
Homo sapiens Homo sapiens Fa 0.44 None 10.1021/jm901371v
Homo sapiens Homo sapiens F_fraction 0.44 None 10.1021/jm901371v
Homo sapiens Homo sapiens Fg 1.0 None 10.1021/jm901371v
Homo sapiens Homo sapiens Fh 1.0 None 10.1021/jm901371v
Homo sapiens Homo sapiens T1/2 1.5 hr 10.1128/aac.01605-07
Homo sapiens Homo sapiens Vdss 0.15 L.kg-1 10.1021/jm901371v
Homo sapiens Kappa opioid receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Melanocortin receptor 3 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Monoamine oxidase A AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Monoamine oxidase A Activity nan None 10.1021/jm800656v
Homo sapiens Motilin receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Multidrug resistance-associated protein 4 Inhibition nan % 10.1124/dmd.111.041731
Homo sapiens Mu opioid receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Muscarinic acetylcholine receptor M1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Muscarinic acetylcholine receptor M2 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Muscarinic acetylcholine receptor M3 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Neuronal acetylcholine receptor protein alpha-4 subunit AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Neuropeptide Y receptor type 1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Norepinephrine transporter AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Oligopeptide transporter small intestine isoform Ki 5000000.0 nM 10.1016/j.ejpb.2004.07.008
Homo sapiens Oligopeptide transporter small intestine isoform Ki 26000000.0 nM 10.1016/j.ejpb.2004.07.008
Homo sapiens Oligopeptide transporter small intestine isoform Ki 26000000.0 nM 10.1021/jm048982w
Homo sapiens Peroxisome proliferator-activated receptor gamma AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Phosphodiesterase 3A AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Phosphodiesterase 4D AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Pregnane X receptor AC50 6100.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Pregnane X receptor AC50 12999.9 nM 10.1038/s41467-023-40064-9
Homo sapiens Pregnane X receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Progesterone receptor AC50 3900.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Progesterone receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 1a (5-HT1a) receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2a (5-HT2a) receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2b (5-HT2b) receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2c (5-HT2c) receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 3a (5-HT3a) receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin transporter AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serum Activity 30.0 % 10.1128/aac.01605-07
Homo sapiens Serum albumin Log K' 1.33 None 10.1021/jm010960b
Homo sapiens Serum albumin pKa nan None 10.1021/acs.jmedchem.0c00046
Homo sapiens Serum albumin PPB 40.1 % 10.1021/acs.jmedchem.0c00046
Homo sapiens Solute carrier family 15 member 2 Ki 12589254.12 nM 10.1016/j.bmc.2011.06.027
Homo sapiens Solute carrier family 15 member 2 Ki 12600000.0 nM 10.1016/j.bmc.2011.06.027
Homo sapiens Solute carrier family 22 member 8 Inhibition nan % 10.1124/dmd.112.049569
Homo sapiens Type-1 angiotensin II receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Vasopressin V1a receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Vasopressin V2 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Janthinobacterium lividum THIN-B proetin Kcat/Km 2.8 10'6/M/s 10.1128/aac.01062-07
Klebsiella Klebsiella MBC 4.68 ug ml-1 10.1021/jm00388a003
Klebsiella Klebsiella MIC 3.71 ug.mL-1 10.1021/jm00388a003
Klebsiella pneumoniae Beta-lactamase AH27 CTX-M-15 Kcat 45.0 /s 10.1128/aac.00461-09
Klebsiella pneumoniae Beta-lactamase AH27 CTX-M-15 Km 180000.0 nM 10.1128/aac.00461-09
Klebsiella pneumoniae Beta-lactamase AH27 CTX-M-15 Ratio 0.25 None 10.1128/aac.00461-09
Klebsiella pneumoniae Beta-lactamase NDM-1 Kcat 5.0 /s 10.1128/aac.00774-09
Klebsiella pneumoniae Beta-lactamase NDM-1 Kcat/Km 0.61 /s/microM 10.1128/aac.00774-09
Klebsiella pneumoniae Beta-lactamase NDM-1 Km 8000.0 nM 10.1128/aac.00774-09
Klebsiella pneumoniae Beta-lactamase SHV-1 Kcat 0.1 /s 10.1128/aac.01525-07
Klebsiella pneumoniae Beta-lactamase SHV-1 Kcat/Km nan None 10.1128/aac.01525-07
Klebsiella pneumoniae Beta-lactamase SHV-1 Km 80000.0 nM 10.1128/aac.01525-07
Klebsiella pneumoniae Beta-lactamase SHV-55 Kcat 7.0 /s 10.1128/aac.01525-07
Klebsiella pneumoniae Beta-lactamase SHV-55 Kcat/Km 0.3 /uM/s 10.1128/aac.01525-07
Klebsiella pneumoniae Beta-lactamase SHV-55 Km 23000.0 nM 10.1128/aac.01525-07
Klebsiella pneumoniae Extended spectrum beta-lactamase CTX-M-71 Kcat 8.8 /s 10.1128/aac.00461-09
Klebsiella pneumoniae Extended spectrum beta-lactamase CTX-M-71 Km 85000.0 nM 10.1128/aac.00461-09
Klebsiella pneumoniae Extended spectrum beta-lactamase CTX-M-71 Ratio 0.1 None 10.1128/aac.00461-09
Klebsiella pneumoniae Klebsiella pneumoniae ED50 9.0 mg.kg-1 10.1021/jm00388a003
Klebsiella pneumoniae Klebsiella pneumoniae MIC 2.0 ug.mL-1 10.1128/aac.01381-07
Klebsiella pneumoniae Klebsiella pneumoniae MIC 8.192 ug.mL-1 10.1016/j.ejmech.2021.113975
Klebsiella pneumoniae Klebsiella pneumoniae MIC 12.5 ug.mL-1 10.1021/jm00388a003
Klebsiella pneumoniae Klebsiella pneumoniae MIC 64.0 ug.mL-1 10.1128/aac.00158-08
Klebsiella pneumoniae Klebsiella pneumoniae MIC 256.0 ug.mL-1 10.1128/aac.00774-09
Klebsiella pneumoniae Klebsiella pneumoniae MIC 256.0 ug.mL-1 10.1128/aac.01284-08
Klebsiella pneumoniae Klebsiella pneumoniae MIC 512.0 ug.mL-1 10.1128/aac.00458-09
Klebsiella pneumoniae Klebsiella pneumoniae MIC 512.0 ug.mL-1 10.1128/aac.00461-09
Klebsiella pneumoniae Klebsiella pneumoniae MIC 1024.0 ug.mL-1 10.1128/aac.00017-09
Klebsiella pneumoniae Metallo-beta-lactamase VIM-2 Kcat 12.0 /s 10.1128/aac.00774-09
Klebsiella pneumoniae Metallo-beta-lactamase VIM-2 Kcat/Km 0.55 /s/microM 10.1128/aac.00774-09
Klebsiella pneumoniae Metallo-beta-lactamase VIM-2 Km 22000.0 nM 10.1128/aac.00774-09
Listeria monocytogenes Listeria monocytogenes FC 2.0 None 10.1128/aac.00290-10
Listeria monocytogenes Listeria monocytogenes FC 2.0 None 10.1128/aac.00503-10
Listeria monocytogenes Listeria monocytogenes IZ 21.1 mm 10.1128/aac.00290-10
Listeria monocytogenes Listeria monocytogenes IZ 21.3 mm 10.1128/aac.00503-10
Listeria monocytogenes Listeria monocytogenes IZ 24.4 mm 10.1128/aac.00290-10
Listeria monocytogenes Listeria monocytogenes IZ 24.8 mm 10.1128/aac.00503-10
Listeria monocytogenes Listeria monocytogenes MIC 1.44 ug.mL-1 10.1128/aac.00290-10
Listeria monocytogenes Listeria monocytogenes MIC 1.44 ug.mL-1 10.1128/aac.00503-10
Listeria monocytogenes Listeria monocytogenes MIC 2.87 ug.mL-1 10.1128/aac.00290-10
Listeria monocytogenes Listeria monocytogenes MIC 2.87 ug.mL-1 10.1128/aac.00503-10
Listeria monocytogenes Listeria monocytogenes MIC 4.0 ug.mL-1 10.1128/aac.01129-07
Listeria monocytogenes Listeria monocytogenes MIC50 32.0 ug.mL-1 10.1128/aac.01129-07
Listeria monocytogenes Listeria monocytogenes MIC90 32.0 ug.mL-1 10.1128/aac.01129-07
Micrococcus luteus Micrococcus luteus MBC nan None 10.1007/s00044-012-0248-y
Micrococcus luteus Micrococcus luteus MBC nan None 10.1016/j.ejmech.2011.10.055
Micrococcus luteus Micrococcus luteus MIC 0.49 ug.mL-1 10.1007/s00044-012-0302-9
Micrococcus luteus Micrococcus luteus MIC 0.98 ug.mL-1 10.1007/s00044-012-0248-y
Micrococcus luteus Micrococcus luteus MIC 0.98 ug.mL-1 10.1016/j.ejmech.2011.10.055
Moraxella catarrhalis Moraxella catarrhalis MIC50 1.0 ug.mL-1 10.1128/aac.00971-07
Moraxella catarrhalis Moraxella catarrhalis MIC90 2.0 ug.mL-1 10.1128/aac.00971-07
Mus musculus Mus musculus Survival 5.0 % 10.1128/aac.00360-06
Mus musculus Mus musculus Survival 91.4 % 10.1128/aac.00360-06
Mus musculus Solute carrier family 22 member 6 Inhibition nan % 10.1124/dmd.112.049569
Mus musculus Solute carrier family 22 member 8 Inhibition nan % 10.1124/dmd.112.049569
Mus musculus Solute carrier family 22 member 8 PPB nan % 10.1124/dmd.112.049569
Neisseria meningitidis Neisseria meningitidis Activity 0.0 % 10.1128/aac.00994-08
Neisseria meningitidis Neisseria meningitidis Activity 1.0 % 10.1128/aac.00994-08
Neisseria meningitidis Neisseria meningitidis Activity 99.0 % 10.1128/aac.00994-08
Neisseria meningitidis Neisseria meningitidis MIC 0.016 ug.mL-1 10.1128/aac.00994-08
Neisseria meningitidis Neisseria meningitidis MIC50 0.047 ug.mL-1 10.1128/aac.00994-08
Neisseria meningitidis Neisseria meningitidis MIC90 0.094 ug.mL-1 10.1128/aac.00994-08
Neisseria perflava Neisseria perflava MBC 0.78 ug ml-1 10.1021/jm00388a003
Neisseria perflava Neisseria perflava MIC 0.39 ug.mL-1 10.1021/jm00388a003
Pectobacterium atrosepticum Pectobacterium atrosepticum MIC 0.5 ug.mL-1 10.1128/aac.01062-07
Prescottella equi Prescottella equi MIC 0.25 ug.mL-1 10.1128/aac.01129-07
Prescottella equi Prescottella equi MIC50 8.0 ug.mL-1 10.1128/aac.01129-07
Prescottella equi Prescottella equi MIC90 16.0 ug.mL-1 10.1128/aac.01129-07
Proteus Proteus MBC 3.9 ug ml-1 10.1021/jm00388a003
Proteus Proteus MIC 1.97 ug.mL-1 10.1021/jm00388a003
Proteus mirabilis Proteus mirabilis MIC 4.0 ug.mL-1 10.1128/aac.01400-08
Proteus mirabilis Proteus mirabilis MIC 16.0 ug.mL-1 10.1128/aac.01399-07
Providencia stuartii Providencia stuartii MIC 1024.0 ug.mL-1 10.1128/aac.00017-09
Pseudomonas Pseudomonas MBC 100.0 ug ml-1 10.1021/jm00388a003
Pseudomonas Pseudomonas MIC 100.0 ug.mL-1 10.1021/jm00388a003
Pseudomonas aeruginosa Beta-lactamase Kcat 0.88 /s 10.1128/aac.00859-09
Pseudomonas aeruginosa Beta-lactamase Kcat/Km 73.0 /mM/s 10.1128/aac.00859-09
Pseudomonas aeruginosa Beta-lactamase Km 12000.0 nM 10.1128/aac.00859-09
Pseudomonas aeruginosa Beta-lactamase bla(BEL1) Kcat 10.0 /s 10.1128/aac.00859-09
Pseudomonas aeruginosa Beta-lactamase bla(BEL1) Kcat/Km 250.0 /mM/s 10.1128/aac.00859-09
Pseudomonas aeruginosa Beta-lactamase bla(BEL1) Km 40000.0 nM 10.1128/aac.00859-09
Pseudomonas aeruginosa Beta-lactamase VIM-1 Kcat 239.0 /s 10.1128/aac.00465-08
Pseudomonas aeruginosa Beta-lactamase VIM-1 Kcat/Km 1.6 /M/s 10.1128/aac.00465-08
Pseudomonas aeruginosa Beta-lactamase VIM-1 Km 148000.0 nM 10.1128/aac.00465-08
Pseudomonas aeruginosa Beta-lactamase VIM-2 Kcat 8.0 /s 10.1128/aac.00166-08
Pseudomonas aeruginosa Beta-lactamase VIM-2 Kcat/Km 0.4 /uM/s 10.1128/aac.00166-08
Pseudomonas aeruginosa Beta-lactamase VIM-2 Km 20000.0 nM 10.1128/aac.00166-08
Pseudomonas aeruginosa Class B carbapenemase VIM-13 Kcat 283.0 /s 10.1128/aac.00465-08
Pseudomonas aeruginosa Class B carbapenemase VIM-13 Kcat/Km 5.0 /M/s 10.1128/aac.00465-08
Pseudomonas aeruginosa Class B carbapenemase VIM-13 Km 56000.0 nM 10.1128/aac.00465-08
Pseudomonas aeruginosa Metallo-beta-lactamase VIM-11 Kcat 27.0 /s 10.1128/aac.01025-07
Pseudomonas aeruginosa Metallo-beta-lactamase VIM-11 Kcat/Km 4.9 10'6/M/s 10.1128/aac.01025-07
Pseudomonas aeruginosa Metallo-beta-lactamase VIM-11 Km 5500.0 nM 10.1128/aac.01025-07
Pseudomonas aeruginosa Metallo-beta-lactamase VIM-2 Kcat 30.5 /s 10.1128/aac.01025-07
Pseudomonas aeruginosa Metallo-beta-lactamase VIM-2 Kcat/Km 5.5 10'6/M/s 10.1128/aac.01025-07
Pseudomonas aeruginosa Metallo-beta-lactamase VIM-2 Km 5500.0 nM 10.1128/aac.01025-07
Pseudomonas aeruginosa Metallo-b-lactamase Kcat 16.0 /s 10.1128/aac.00166-08
Pseudomonas aeruginosa Metallo-b-lactamase Kcat/Km 0.55 /uM/s 10.1128/aac.00166-08
Pseudomonas aeruginosa Metallo-b-lactamase Km 29000.0 nM 10.1128/aac.00166-08
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 98.0 ug.mL-1 10.1016/j.ejmech.2020.112832
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 512.0 ug.mL-1 10.1128/aac.00859-09
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC nan None 10.1128/aac.01561-09
Pseudomonas fluorescens Beta-lactamase Kcat/Km 9.0 /mM/s 10.1128/aac.00961-09
Pseudomonas fluorescens Pseudomonas fluorescens MIC 256.0 ug.mL-1 10.1128/aac.00961-09
Pseudomonas luteola Beta-lactamase Kcat 286.0 /s 10.1128/aac.00427-09
Pseudomonas luteola Beta-lactamase Kcat/Km 11.91 /s/microM 10.1128/aac.00427-09
Pseudomonas luteola Beta-lactamase Km 24000.0 nM 10.1128/aac.00427-09
Rattus norvegicus Androgen Receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Rattus norvegicus Cyclooxygenase-1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Rattus norvegicus GABA receptor alpha-1 subunit AC50 30000.0 nM 10.1038/s41467-023-40064-9
Rattus norvegicus Glutamate (NMDA) receptor subunit zeta 1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Rattus norvegicus Oligopeptide transporter, kidney isoform Ki 3000.0 nM 10.1016/j.ejpb.2004.07.008
Rattus norvegicus Oligopeptide transporter, kidney isoform Ki 12600000.0 nM 10.1016/j.ejpb.2004.07.008
Rattus norvegicus Plasma Fu 0.36 None 10.1021/jm901371v
Salmonella Salmonella MBC 6.7 ug ml-1 10.1021/jm00388a003
Salmonella Salmonella MIC 3.12 ug.mL-1 10.1021/jm00388a003
Salmonella enterica Salmonella enterica MIC 32.0 ug.mL-1 10.1128/aac.00310-09
Salmonella enterica subsp. enterica serovar Typhimurium Salmonella typhimurium ED50 90.0 mg.kg-1 10.1021/jm00388a003
Salmonella enterica subsp. enterica serovar Typhimurium Salmonella typhimurium MIC 1.56 ug.mL-1 10.1021/jm00388a003
Salmonella enterica subsp. enterica serovar Typhimurium Salmonella typhimurium MIC 4.0 ug.mL-1 10.1128/aac.00205-08
Salmonella enterica subsp. enterica serovar Westhampton Extended-spectrum beta-lactamase CTX-M-53 Kcat 292.0 /s 10.1128/aac.01581-08
Salmonella enterica subsp. enterica serovar Westhampton Extended-spectrum beta-lactamase CTX-M-53 Kcat/Km 3.6 /s/microM 10.1128/aac.01581-08
Salmonella enterica subsp. enterica serovar Westhampton Extended-spectrum beta-lactamase CTX-M-53 Km 80000.0 nM 10.1128/aac.01581-08
Sarcina Sarcina MBC 0.55 ug ml-1 10.1021/jm00388a003
Sarcina Sarcina MIC 0.39 ug.mL-1 10.1021/jm00388a003
Serratia Serratia MBC 28.02 ug ml-1 10.1021/jm00388a003
Serratia Serratia MIC 12.4 ug.mL-1 10.1021/jm00388a003
Severe acute respiratory syndrome coronavirus 2 Replicase polyprotein 1ab Inhibition 3.14 % 10.6019/CHEMBL4495564
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Hit score 0.29 None 10.1101/2020.04.21.054387
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 IC50 19952.62 nM 10.6019/CHEMBL4651402
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 IC50 20000.0 nM 10.6019/CHEMBL4651402
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Inhibition 0.18 % 10.6019/CHEMBL4495565
Shouchella clausii Shouchella clausii Activity nan None 10.1128/aac.00537-07
Shouchella clausii Shouchella clausii MIC 128000.0 ug.mL-1 10.1128/aac.00537-07
Staphylococcus Staphylococcus MBC 1.67 ug ml-1 10.1021/jm00388a003
Staphylococcus Staphylococcus MBC 17.68 ug ml-1 10.1021/jm00388a003
Staphylococcus Staphylococcus MIC 1.06 ug.mL-1 10.1021/jm00388a003
Staphylococcus Staphylococcus MIC 10.51 ug.mL-1 10.1021/jm00388a003
Staphylococcus Staphylococcus MIC 600.0 ug.mL-1 10.1016/j.ejmech.2015.07.002
Staphylococcus aureus Staphylococcus aureus Activity 0.26 mg/L 10.1128/aac.01135-08
Staphylococcus aureus Staphylococcus aureus Activity 70.0 % 10.1016/j.ejmech.2018.11.052
Staphylococcus aureus Staphylococcus aureus Activity 200.0 mg/L 10.1128/aac.01135-08
Staphylococcus aureus Staphylococcus aureus Activity nan None 10.1016/j.bmc.2019.115095
Staphylococcus aureus Staphylococcus aureus Activity nan None 10.1016/j.ejmech.2018.11.052
Staphylococcus aureus Staphylococcus aureus Activity nan None 10.1128/aac.01605-07
Staphylococcus aureus Staphylococcus aureus EC50 0.27 ug.mL-1 10.1128/aac.01135-08
Staphylococcus aureus Staphylococcus aureus FC 2.0 None 10.1128/aac.01605-07
Staphylococcus aureus Staphylococcus aureus FC 4.0 None 10.1128/aac.01135-08
Staphylococcus aureus Staphylococcus aureus FC 16.0 None 10.1128/aac.01135-08
Staphylococcus aureus Staphylococcus aureus FC 128.0 None 10.1128/aac.01135-08
Staphylococcus aureus Staphylococcus aureus log10cfu -0.42 None 10.1128/aac.01135-08
Staphylococcus aureus Staphylococcus aureus log10cfu 2.75 None 10.1128/aac.01135-08
Staphylococcus aureus Staphylococcus aureus log10cfu 3.23 None 10.1128/aac.01135-08
Staphylococcus aureus Staphylococcus aureus MBC nan None 10.1007/s00044-012-0248-y
Staphylococcus aureus Staphylococcus aureus MBC nan None 10.1016/j.ejmech.2011.10.055
Staphylococcus aureus Staphylococcus aureus MIC 0.49 ug.mL-1 10.1007/s00044-012-0248-y
Staphylococcus aureus Staphylococcus aureus MIC 0.49 ug.mL-1 10.1007/s00044-012-0302-9
Staphylococcus aureus Staphylococcus aureus MIC 0.49 ug.mL-1 10.1016/j.ejmech.2011.10.055
Staphylococcus aureus Staphylococcus aureus MIC 0.98 ug.mL-1 10.1016/j.ejmech.2011.10.055
Staphylococcus aureus Staphylococcus aureus MIC 1.0 ug.mL-1 10.1016/j.ejmech.2017.09.048
Staphylococcus aureus Staphylococcus aureus MIC 1.0 ug.mL-1 10.1016/s0960-894x(99)00127-4
Staphylococcus aureus Staphylococcus aureus MIC 1.0 ug.mL-1 10.1128/aac.01325-09
Staphylococcus aureus Staphylococcus aureus MIC 1.95 ug.mL-1 10.1007/s00044-012-0302-9
Staphylococcus aureus Staphylococcus aureus MIC 2.0 ug.mL-1 10.1016/j.ejmech.2017.09.048
Staphylococcus aureus Staphylococcus aureus MIC 2.0 ug.mL-1 10.1016/j.ejmech.2018.11.052
Staphylococcus aureus Staphylococcus aureus MIC 2.0 ug.mL-1 10.1016/s0960-894x(99)00127-4
Staphylococcus aureus Staphylococcus aureus MIC 2.0 ug.mL-1 10.1128/aac.01247-08
Staphylococcus aureus Staphylococcus aureus MIC 2.0 ug.mL-1 10.1128/aac.01605-07
Staphylococcus aureus Staphylococcus aureus MIC 8.0 ug.mL-1 10.1016/j.ejmech.2017.09.048
Staphylococcus aureus Staphylococcus aureus MIC 8.0 ug.mL-1 10.1016/j.ejmech.2018.11.052
Staphylococcus aureus Staphylococcus aureus MIC 16.0 ug.mL-1 10.1016/j.ejmech.2018.11.052
Staphylococcus aureus Staphylococcus aureus MIC 32.0 ug.mL-1 10.1016/j.ejmech.2018.11.052
Staphylococcus aureus Staphylococcus aureus MIC 64.0 ug.mL-1 10.1016/j.ejmech.2018.11.052
Staphylococcus aureus Staphylococcus aureus MIC 128.0 ug.mL-1 10.1016/j.ejmech.2017.09.048
Staphylococcus aureus Staphylococcus aureus MIC 256.0 ug.mL-1 10.1016/j.ejmech.2018.11.052
Staphylococcus aureus Staphylococcus aureus MIC 512.0 ug.mL-1 10.1016/j.ejmech.2018.11.052
Staphylococcus aureus Staphylococcus aureus MIC 1024.0 ug.mL-1 10.1016/j.ejmech.2018.11.052
Staphylococcus aureus Staphylococcus aureus MIC nan None 10.1007/s00044-012-0248-y
Staphylococcus aureus Staphylococcus aureus MIC90 1.0 ug.mL-1 10.1128/aac.01325-09
Staphylococcus epidermidis Staphylococcus epidermidis MBC nan None 10.1007/s00044-012-0248-y
Staphylococcus epidermidis Staphylococcus epidermidis MBC nan None 10.1016/j.ejmech.2011.10.055
Staphylococcus epidermidis Staphylococcus epidermidis MIC 0.24 ug.mL-1 10.1007/s00044-012-0248-y
Staphylococcus epidermidis Staphylococcus epidermidis MIC 0.24 ug.mL-1 10.1007/s00044-012-0302-9
Staphylococcus epidermidis Staphylococcus epidermidis MIC 0.24 ug.mL-1 10.1016/j.ejmech.2011.10.055
Staphylococcus epidermidis Staphylococcus epidermidis MIC 0.5 ug.mL-1 10.1016/j.ejmech.2017.09.048
Staphylococcus epidermidis Staphylococcus epidermidis MIC 32.0 ug.mL-1 10.1016/j.ejmech.2017.09.048
Staphylococcus hominis Staphylococcus hominis MIC 8.0 ug.mL-1 10.1016/j.ejmech.2017.09.048
Stenotrophomonas maltophilia Beta-lactamase L1 Kcat/Km 2.7 10'6/M/s 10.1128/aac.01062-07
Stenotrophomonas maltophilia Catechol 2,3-dioxygenase Activity 0.0 U/min 10.1128/aac.01283-09
Stenotrophomonas maltophilia Catechol 2,3-dioxygenase Activity 4.0 U/min 10.1128/aac.01283-09
Stenotrophomonas maltophilia Catechol 2,3-dioxygenase Activity 5.0 U/min 10.1128/aac.01283-09
Stenotrophomonas maltophilia Catechol 2,3-dioxygenase Activity 6.0 U/min 10.1128/aac.01283-09
Stenotrophomonas maltophilia Catechol 2,3-dioxygenase Activity 8.0 U/min 10.1128/aac.01283-09
Stenotrophomonas maltophilia Catechol 2,3-dioxygenase Activity 39.0 U/min 10.1128/aac.01283-09
Stenotrophomonas maltophilia Catechol 2,3-dioxygenase Activity 41.0 U/min 10.1128/aac.01283-09
Stenotrophomonas maltophilia Catechol 2,3-dioxygenase Activity 45.0 U/min 10.1128/aac.01283-09
Stenotrophomonas maltophilia Catechol 2,3-dioxygenase Activity 50.0 U/min 10.1128/aac.01283-09
Stenotrophomonas maltophilia Stenotrophomonas maltophilia Activity nan None 10.1128/aac.00682-07
Stenotrophomonas maltophilia Stenotrophomonas maltophilia MIC 32.0 ug.mL-1 10.1128/aac.01283-09
Stenotrophomonas maltophilia Stenotrophomonas maltophilia MIC 64.0 ug.mL-1 10.1128/aac.01283-09
Stenotrophomonas maltophilia Stenotrophomonas maltophilia MIC 1024.0 ug.mL-1 10.1128/aac.00682-07
Stenotrophomonas maltophilia Stenotrophomonas maltophilia MIC 1024.0 ug.mL-1 10.1128/aac.01283-09
Stenotrophomonas maltophilia Stenotrophomonas maltophilia MIC 2048.0 ug.mL-1 10.1128/aac.00682-07
Stenotrophomonas maltophilia Stenotrophomonas maltophilia MIC 2048.0 ug.mL-1 10.1128/aac.01513-08
Stenotrophomonas maltophilia Stenotrophomonas maltophilia Ratio 2.4 None 10.1128/aac.00682-07
Streptococcus Streptococcus MBC 59.46 ug ml-1 10.1021/jm00388a003
Streptococcus Streptococcus MIC 15.14 ug.mL-1 10.1021/jm00388a003
Streptococcus agalactiae Streptococcus agalactiae MIC 0.12 ug.mL-1 10.1128/aac.01398-07
Streptococcus agalactiae Streptococcus agalactiae MIC50 0.12 ug.mL-1 10.1128/aac.01398-07
Streptococcus agalactiae Streptococcus agalactiae MIC90 0.12 ug.mL-1 10.1128/aac.01398-07
Streptococcus constellatus Streptococcus constellatus MIC 0.12 ug.mL-1 10.1128/aac.01398-07
Streptococcus constellatus Streptococcus constellatus MIC50 nan None 10.1128/aac.01398-07
Streptococcus constellatus Streptococcus constellatus MIC90 nan None 10.1128/aac.01398-07
Streptococcus intermedius Streptococcus intermedius MIC 0.12 ug.mL-1 10.1128/aac.01398-07
Streptococcus intermedius Streptococcus intermedius MIC50 nan None 10.1128/aac.01398-07
Streptococcus intermedius Streptococcus intermedius MIC90 nan None 10.1128/aac.01398-07
Streptococcus mitis Streptococcus mitis MIC 0.12 ug.mL-1 10.1128/aac.01398-07
Streptococcus mitis Streptococcus mitis MIC50 nan None 10.1128/aac.01398-07
Streptococcus mitis Streptococcus mitis MIC90 nan None 10.1128/aac.01398-07
Streptococcus oralis Streptococcus oralis MIC 0.12 ug.mL-1 10.1128/aac.01398-07
Streptococcus oralis Streptococcus oralis MIC50 nan None 10.1128/aac.01398-07
Streptococcus oralis Streptococcus oralis MIC90 nan None 10.1128/aac.01398-07
Streptococcus pneumoniae Streptococcus pneumoniae Activity 0.0 % 10.1128/aac.00712-08
Streptococcus pneumoniae Streptococcus pneumoniae Activity 0.0 % 10.1128/aac.00971-07
Streptococcus pneumoniae Streptococcus pneumoniae Activity 0.0 % 10.1128/aac.01797-09
Streptococcus pneumoniae Streptococcus pneumoniae Activity 1.3 % 10.1128/aac.01548-09
Streptococcus pneumoniae Streptococcus pneumoniae Activity 2.0 % 10.1128/aac.01398-07
Streptococcus pneumoniae Streptococcus pneumoniae Activity 5.5 % 10.1128/aac.01548-09
Streptococcus pneumoniae Streptococcus pneumoniae Activity 9.6 % 10.1128/aac.01797-09
Streptococcus pneumoniae Streptococcus pneumoniae Activity 12.7 % 10.1128/aac.00971-07
Streptococcus pneumoniae Streptococcus pneumoniae Activity 17.0 % 10.1128/aac.01398-07
Streptococcus pneumoniae Streptococcus pneumoniae Activity 18.7 % 10.1128/aac.00971-07
Streptococcus pneumoniae Streptococcus pneumoniae Activity 20.7 % 10.1128/aac.01797-09
Streptococcus pneumoniae Streptococcus pneumoniae Activity 26.8 % 10.1128/aac.00712-08
Streptococcus pneumoniae Streptococcus pneumoniae Activity 31.6 % 10.1128/aac.00712-08
Streptococcus pneumoniae Streptococcus pneumoniae Activity 36.1 % 10.1128/aac.01797-09
Streptococcus pneumoniae Streptococcus pneumoniae Activity 47.5 % 10.1128/aac.01797-09
Streptococcus pneumoniae Streptococcus pneumoniae Activity 55.3 % 10.1128/aac.00712-08
Streptococcus pneumoniae Streptococcus pneumoniae Activity 74.0 % 10.1128/aac.00971-07
Streptococcus pneumoniae Streptococcus pneumoniae Activity 78.2 % 10.1128/aac.00971-07
Streptococcus pneumoniae Streptococcus pneumoniae Activity 83.8 % 10.1128/aac.01548-09
Streptococcus pneumoniae Streptococcus pneumoniae Activity 91.4 % 10.1128/aac.01797-09
Streptococcus pneumoniae Streptococcus pneumoniae Activity 94.5 % 10.1128/aac.01548-09
Streptococcus pneumoniae Streptococcus pneumoniae Activity 95.2 % 10.1128/aac.01797-09
Streptococcus pneumoniae Streptococcus pneumoniae Activity 96.4 % 10.1128/aac.01797-09
Streptococcus pneumoniae Streptococcus pneumoniae Activity 96.8 % 10.1128/aac.01797-09
Streptococcus pneumoniae Streptococcus pneumoniae Activity 99.2 % 10.1128/aac.00971-07
Streptococcus pneumoniae Streptococcus pneumoniae Activity 99.3 % 10.1128/aac.01548-09
Streptococcus pneumoniae Streptococcus pneumoniae Activity 99.9 % 10.1128/aac.00971-07
Streptococcus pneumoniae Streptococcus pneumoniae Activity 100.0 % 10.1128/aac.01797-09
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.016 ug.mL-1 10.1128/aac.01150-06
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.016 ug.mL-1 10.1128/aac.01531-08
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.016 ug.mL-1 10.1128/aac.01620-07
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.03 ug.mL-1 10.1128/aac.01150-06
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.03 ug.mL-1 10.1128/aac.01531-08
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.03 ug.mL-1 10.1128/aac.01566-08
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.03 ug.mL-1 10.1128/aac.01620-07
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.06 ug.mL-1 10.1016/s0960-894x(99)00127-4
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.12 ug.mL-1 10.1128/aac.00100-07
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.12 ug.mL-1 10.1128/aac.01082-07
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.125 ug.mL-1 10.1128/aac.01150-06
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.125 ug.mL-1 10.1128/aac.01531-08
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.125 ug.mL-1 10.1128/aac.01566-08
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.25 ug.mL-1 10.1016/s0960-894x(99)00127-4
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.25 ug.mL-1 10.1128/aac.01082-07
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.25 ug.mL-1 10.1128/aac.01150-06
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.25 ug.mL-1 10.1128/aac.01531-08
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.25 ug.mL-1 10.1128/aac.01566-08
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.5 ug.mL-1 10.1128/aac.01150-06
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.5 ug.mL-1 10.1128/aac.01398-07
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.5 ug.mL-1 10.1128/aac.01531-08
Streptococcus pneumoniae Streptococcus pneumoniae MIC 1.0 ug.mL-1 10.1128/aac.01398-07
Streptococcus pneumoniae Streptococcus pneumoniae MIC 1.0 ug.mL-1 10.1128/aac.01531-08
Streptococcus pneumoniae Streptococcus pneumoniae MIC 1.0 ug.mL-1 10.1128/aac.01620-07
Streptococcus pneumoniae Streptococcus pneumoniae MIC 1.0 ug.mL-1 10.1128/aac.01797-09
Streptococcus pneumoniae Streptococcus pneumoniae MIC 2.0 ug.mL-1 10.1128/aac.01082-07
Streptococcus pneumoniae Streptococcus pneumoniae MIC 2.0 ug.mL-1 10.1128/aac.01150-06
Streptococcus pneumoniae Streptococcus pneumoniae MIC 2.0 ug.mL-1 10.1128/aac.01531-08
Streptococcus pneumoniae Streptococcus pneumoniae MIC 2.0 ug.mL-1 10.1128/aac.01566-08
Streptococcus pneumoniae Streptococcus pneumoniae MIC 2.0 ug.mL-1 10.1128/aac.01797-09
Streptococcus pneumoniae Streptococcus pneumoniae MIC 4.0 ug.mL-1 10.1128/aac.00100-07
Streptococcus pneumoniae Streptococcus pneumoniae MIC 4.0 ug.mL-1 10.1128/aac.01082-07
Streptococcus pneumoniae Streptococcus pneumoniae MIC 4.0 ug.mL-1 10.1128/aac.01531-08
Streptococcus pneumoniae Streptococcus pneumoniae MIC 4.0 ug.mL-1 10.1128/aac.01566-08
Streptococcus pneumoniae Streptococcus pneumoniae MIC 8.0 ug.mL-1 10.1128/aac.01082-07
Streptococcus pneumoniae Streptococcus pneumoniae MIC 8.0 ug.mL-1 10.1128/aac.01531-08
Streptococcus pneumoniae Streptococcus pneumoniae MIC 8.0 ug.mL-1 10.1128/aac.01566-08
Streptococcus pneumoniae Streptococcus pneumoniae MIC 16.0 ug.mL-1 10.1016/s0960-894x(99)00127-4
Streptococcus pneumoniae Streptococcus pneumoniae MIC 16.0 ug.mL-1 10.1128/aac.01082-07
Streptococcus pneumoniae Streptococcus pneumoniae MIC 16.0 ug.mL-1 10.1128/aac.01150-06
Streptococcus pneumoniae Streptococcus pneumoniae MIC 16.0 ug.mL-1 10.1128/aac.01531-08
Streptococcus pneumoniae Streptococcus pneumoniae MIC 16.0 ug.mL-1 10.1128/aac.01566-08
Streptococcus pneumoniae Streptococcus pneumoniae MIC 32.0 ug.mL-1 10.1016/s0960-894x(99)00127-4
Streptococcus pneumoniae Streptococcus pneumoniae MIC 32.0 ug.mL-1 10.1128/aac.01082-07
Streptococcus pneumoniae Streptococcus pneumoniae MIC 32.0 ug.mL-1 10.1128/aac.01531-08
Streptococcus pneumoniae Streptococcus pneumoniae MIC 64.0 ug.mL-1 10.1128/aac.01531-08
Streptococcus pneumoniae Streptococcus pneumoniae MIC50 0.015 ug.mL-1 10.1128/aac.01548-09
Streptococcus pneumoniae Streptococcus pneumoniae MIC50 0.03 ug.mL-1 10.1128/aac.01531-08
Streptococcus pneumoniae Streptococcus pneumoniae MIC50 0.03 ug.mL-1 10.1128/aac.01620-07
Streptococcus pneumoniae Streptococcus pneumoniae MIC50 0.12 ug.mL-1 10.1128/aac.00100-07
Streptococcus pneumoniae Streptococcus pneumoniae MIC50 0.25 ug.mL-1 10.1128/aac.00712-08
Streptococcus pneumoniae Streptococcus pneumoniae MIC50 0.25 ug.mL-1 10.1128/aac.01531-08
Streptococcus pneumoniae Streptococcus pneumoniae MIC50 0.25 ug.mL-1 10.1128/aac.01620-07
Streptococcus pneumoniae Streptococcus pneumoniae MIC50 0.5 ug.mL-1 10.1128/aac.00100-07
Streptococcus pneumoniae Streptococcus pneumoniae MIC50 0.5 ug.mL-1 10.1128/aac.00971-07
Streptococcus pneumoniae Streptococcus pneumoniae MIC50 0.5 ug.mL-1 10.1128/aac.01620-07
Streptococcus pneumoniae Streptococcus pneumoniae MIC50 1.0 ug.mL-1 10.1128/aac.01797-09
Streptococcus pneumoniae Streptococcus pneumoniae MIC50 2.0 ug.mL-1 10.1128/aac.01398-07
Streptococcus pneumoniae Streptococcus pneumoniae MIC50 2.0 ug.mL-1 10.1128/aac.01620-07
Streptococcus pneumoniae Streptococcus pneumoniae MIC50 2.0 ug.mL-1 10.1128/aac.01797-09
Streptococcus pneumoniae Streptococcus pneumoniae MIC50 4.0 ug.mL-1 10.1128/aac.00100-07
Streptococcus pneumoniae Streptococcus pneumoniae MIC50 4.0 ug.mL-1 10.1128/aac.00712-08
Streptococcus pneumoniae Streptococcus pneumoniae MIC50 4.0 ug.mL-1 10.1128/aac.01398-07
Streptococcus pneumoniae Streptococcus pneumoniae MIC50 4.0 ug.mL-1 10.1128/aac.01531-08
Streptococcus pneumoniae Streptococcus pneumoniae MIC50 4.0 ug.mL-1 10.1128/aac.01620-07
Streptococcus pneumoniae Streptococcus pneumoniae MIC50 4.0 ug.mL-1 10.1128/aac.01797-09
Streptococcus pneumoniae Streptococcus pneumoniae MIC50 8.0 ug.mL-1 10.1128/aac.00712-08
Streptococcus pneumoniae Streptococcus pneumoniae MIC50 8.0 ug.mL-1 10.1128/aac.00971-07
Streptococcus pneumoniae Streptococcus pneumoniae MIC50 8.0 ug.mL-1 10.1128/aac.01531-08
Streptococcus pneumoniae Streptococcus pneumoniae MIC50 8.0 ug.mL-1 10.1128/aac.01797-09
Streptococcus pneumoniae Streptococcus pneumoniae MIC50 16.0 ug.mL-1 10.1128/aac.00712-08
Streptococcus pneumoniae Streptococcus pneumoniae MIC90 0.12 ug.mL-1 10.1128/aac.00100-07
Streptococcus pneumoniae Streptococcus pneumoniae MIC90 0.12 ug.mL-1 10.1128/aac.01620-07
Streptococcus pneumoniae Streptococcus pneumoniae MIC90 0.125 ug.mL-1 10.1128/aac.01531-08
Streptococcus pneumoniae Streptococcus pneumoniae MIC90 0.5 ug.mL-1 10.1128/aac.00971-07
Streptococcus pneumoniae Streptococcus pneumoniae MIC90 0.5 ug.mL-1 10.1128/aac.01620-07
Streptococcus pneumoniae Streptococcus pneumoniae MIC90 1.0 ug.mL-1 10.1128/aac.01548-09
Streptococcus pneumoniae Streptococcus pneumoniae MIC90 1.0 ug.mL-1 10.1128/aac.01797-09
Streptococcus pneumoniae Streptococcus pneumoniae MIC90 4.0 ug.mL-1 10.1128/aac.00100-07
Streptococcus pneumoniae Streptococcus pneumoniae MIC90 4.0 ug.mL-1 10.1128/aac.00971-07
Streptococcus pneumoniae Streptococcus pneumoniae MIC90 4.0 ug.mL-1 10.1128/aac.01398-07
Streptococcus pneumoniae Streptococcus pneumoniae MIC90 4.0 ug.mL-1 10.1128/aac.01531-08
Streptococcus pneumoniae Streptococcus pneumoniae MIC90 4.0 ug.mL-1 10.1128/aac.01620-07
Streptococcus pneumoniae Streptococcus pneumoniae MIC90 4.0 ug.mL-1 10.1128/aac.01797-09
Streptococcus pneumoniae Streptococcus pneumoniae MIC90 8.0 ug.mL-1 10.1128/aac.00712-08
Streptococcus pneumoniae Streptococcus pneumoniae MIC90 8.0 ug.mL-1 10.1128/aac.00971-07
Streptococcus pneumoniae Streptococcus pneumoniae MIC90 8.0 ug.mL-1 10.1128/aac.01620-07
Streptococcus pneumoniae Streptococcus pneumoniae MIC90 8.0 ug.mL-1 10.1128/aac.01797-09
Streptococcus pneumoniae Streptococcus pneumoniae MIC90 16.0 ug.mL-1 10.1128/aac.00712-08
Streptococcus pneumoniae Streptococcus pneumoniae MIC90 16.0 ug.mL-1 10.1128/aac.00971-07
Streptococcus pneumoniae Streptococcus pneumoniae MIC90 16.0 ug.mL-1 10.1128/aac.01531-08
Streptococcus pneumoniae Streptococcus pneumoniae MIC90 16.0 ug.mL-1 10.1128/aac.01620-07
Streptococcus pneumoniae Streptococcus pneumoniae MIC90 32.0 ug.mL-1 10.1128/aac.00712-08
Streptococcus pneumoniae Streptococcus pneumoniae Post Antibiotic Effe 1.5 hr 10.1128/aac.01150-06
Streptococcus pneumoniae R6 Penicillin-binding protein 2X Activity nan None 10.1021/jm900625q
Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4) Penicillin-binding protein 1A IC50 0.001 ug.mL-1 10.1128/aac.01566-08
Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4) Penicillin-binding protein 1A IC50 0.002 ug.mL-1 10.1128/aac.01566-08
Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4) Penicillin-binding protein 1A IC50 0.004 ug.mL-1 10.1128/aac.01566-08
Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4) Penicillin-binding protein 1A IC50 0.006 ug.mL-1 10.1128/aac.01566-08
Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4) Penicillin-binding protein 1A IC50 0.008 ug.mL-1 10.1128/aac.01566-08
Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4) Penicillin-binding protein 1A IC50 0.01 ug.mL-1 10.1128/aac.01566-08
Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4) Penicillin-binding protein 1A IC50 0.164 ug.mL-1 10.1128/aac.01566-08
Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4) Penicillin-binding protein 2B IC50 0.0005 ug.mL-1 10.1128/aac.01566-08
Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4) Penicillin-binding protein 2B IC50 0.023 ug.mL-1 10.1128/aac.01566-08
Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4) Penicillin-binding protein 2B IC50 0.038 ug.mL-1 10.1128/aac.01566-08
Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4) Penicillin-binding protein 2B IC50 0.171 ug.mL-1 10.1128/aac.01566-08
Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4) Penicillin-binding protein 2B IC50 0.472 ug.mL-1 10.1128/aac.01566-08
Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4) Penicillin-binding protein 2B IC50 1.164 ug.mL-1 10.1128/aac.01566-08
Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4) Penicillin-binding protein 2B IC50 1.656 ug.mL-1 10.1128/aac.01566-08
Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4) Penicillin-binding protein 2B IC50 2.646 ug.mL-1 10.1128/aac.01566-08
Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4) Penicillin-binding protein 2B IC50 14.74 ug.mL-1 10.1128/aac.01566-08
Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4) Penicillin-binding protein 2x Activity nan None 10.1021/jm900625q
Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4) Penicillin-binding protein 2x IC50 4e-05 ug.mL-1 10.1128/aac.01566-08
Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4) Penicillin-binding protein 2x IC50 0.002 ug.mL-1 10.1128/aac.01566-08
Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4) Penicillin-binding protein 2x IC50 0.003 ug.mL-1 10.1128/aac.01566-08
Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4) Penicillin-binding protein 2x IC50 0.004 ug.mL-1 10.1128/aac.01566-08
Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4) Penicillin-binding protein 2x IC50 0.006 ug.mL-1 10.1128/aac.01566-08
Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4) Penicillin-binding protein 2x IC50 0.014 ug.mL-1 10.1128/aac.01566-08
Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4) Penicillin-binding protein 2x IC50 0.02 ug.mL-1 10.1128/aac.01566-08
Streptococcus pyogenes Streptococcus pyogenes MIC 0.0313 ug.mL-1 10.1128/aac.00604-06
Streptococcus pyogenes Streptococcus pyogenes MIC 0.06 ug.mL-1 10.1016/s0960-894x(99)00127-4
Streptococcus pyogenes Streptococcus pyogenes MIC 0.12 ug.mL-1 10.1128/aac.01398-07
Streptococcus pyogenes Streptococcus pyogenes MIC50 0.015 ug.mL-1 10.1128/aac.01548-09
Streptococcus pyogenes Streptococcus pyogenes MIC50 0.12 ug.mL-1 10.1128/aac.01398-07
Streptococcus pyogenes Streptococcus pyogenes MIC90 0.015 ug.mL-1 10.1128/aac.01548-09
Streptococcus pyogenes Streptococcus pyogenes MIC90 0.25 ug.mL-1 10.1128/aac.01398-07
Streptococcus sp. 'group A' Streptococcus sp. 'group A' MIC 0.016 ug.mL-1 10.1128/aac.01620-07
Streptococcus sp. 'group A' Streptococcus sp. 'group A' MIC 0.12 ug.mL-1 10.1128/aac.00100-07
Streptococcus sp. 'group A' Streptococcus sp. 'group A' MIC50 0.016 ug.mL-1 10.1128/aac.01620-07
Streptococcus sp. 'group A' Streptococcus sp. 'group A' MIC50 0.12 ug.mL-1 10.1128/aac.00100-07
Streptococcus sp. 'group A' Streptococcus sp. 'group A' MIC90 0.016 ug.mL-1 10.1128/aac.01620-07
Streptococcus sp. 'group A' Streptococcus sp. 'group A' MIC90 0.03 ug.mL-1 10.1128/aac.01620-07
Streptococcus sp. 'group A' Streptococcus sp. 'group A' MIC90 0.12 ug.mL-1 10.1128/aac.00100-07
Streptococcus sp. 'group B' Streptococcus sp. 'group B' MIC 0.03 ug.mL-1 10.1128/aac.00461-08
Streptococcus sp. 'group B' Streptococcus sp. 'group B' MIC 0.06 ug.mL-1 10.1128/aac.00461-08
Streptococcus sp. 'group B' Streptococcus sp. 'group B' MIC 0.12 ug.mL-1 10.1128/aac.00100-07
Streptococcus sp. 'group B' Streptococcus sp. 'group B' MIC 0.12 ug.mL-1 10.1128/aac.00461-08
Streptococcus sp. 'group B' Streptococcus sp. 'group B' MIC 0.25 ug.mL-1 10.1128/aac.00461-08
Streptococcus sp. 'group B' Streptococcus sp. 'group B' MIC 0.5 ug.mL-1 10.1128/aac.00461-08
Streptococcus sp. 'group B' Streptococcus sp. 'group B' MIC nan None 10.1128/aac.00461-08
Streptococcus sp. 'group B' Streptococcus sp. 'group B' MIC50 0.12 ug.mL-1 10.1128/aac.00100-07
Streptococcus sp. 'group B' Streptococcus sp. 'group B' MIC90 0.12 ug.mL-1 10.1128/aac.00100-07
Streptococcus viridans Streptococcus viridans MIC 0.12 ug.mL-1 10.1128/aac.00100-07
Streptococcus viridans Streptococcus viridans MIC 0.12 ug.mL-1 10.1128/aac.01398-07
Streptococcus viridans Streptococcus viridans MIC50 0.12 ug.mL-1 10.1128/aac.00100-07
Streptococcus viridans Streptococcus viridans MIC50 nan None 10.1128/aac.01398-07
Streptococcus viridans Streptococcus viridans MIC90 2.0 ug.mL-1 10.1128/aac.00100-07
Streptococcus viridans Streptococcus viridans MIC90 nan None 10.1128/aac.01398-07
Sus scrofa LLC-PK1 Papp 2.0 ucm/s 10.1021/jm401635n
Sus scrofa LLC-PK1 Ratio 2.0 None 10.1021/jm401635n
Yersinia enterocolitica Yersinia enterocolitica MIC 0.5 ug.mL-1 10.1128/aac.01754-09
Yersinia enterocolitica Yersinia enterocolitica MIC 0.75 ug.mL-1 10.1128/aac.01754-09
None ADMET CL 2.2 mL.min-1.kg-1 10.1124/dmd.108.020479
None ADMET log10(%HIA +10) 1.176 None 10.1016/j.ejmech.2010.11.005
None ADMET MRT 1.1 hr 10.1124/dmd.108.020479
None ADMET permeability 0.3 10^-6 cm/s 10.1016/j.ejmech.2020.112593
None ADMET PPB 31.5 % 10.1021/acs.jmedchem.0c00046
None ADMET T1/2 1.1 hr 10.1124/dmd.108.020479
None ADMET Vdss 0.15 L.kg-1 10.1124/dmd.108.020479
None Hepatotoxicity Alkaline Phosphatase Increase - Activity Score nan None 10.2174/1570163043334794
None Hepatotoxicity Alkaline Phosphatase Increase - Index Value 0.0 None 10.2174/1570163043334794
None Hepatotoxicity Alkaline Phosphatase Increase - Number of Reports 4.0 None 10.2174/1570163043334794
None Hepatotoxicity Composite Activity - Active 0.0 None 10.2174/1570163043334794
None Hepatotoxicity Composite Activity - Marginal 0.0 None 10.2174/1570163043334794
None Hepatotoxicity Composite Activity - Score nan None 10.2174/1570163043334794
None Hepatotoxicity GGT Increase - Activity Score nan None 10.2174/1570163043334794
None Hepatotoxicity GGT Increase - Index Value 0.0 None 10.2174/1570163043334794
None Hepatotoxicity GGT Increase - Number of Reports 4.0 None 10.2174/1570163043334794
None Hepatotoxicity HepSE_bilirubinemia 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_cholecystitis 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_cholelithiasis 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_cirrhosis 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_Combined Scores 2.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_elevated liver function tests 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_hepatic failure 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_hepatic necrosis 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_hepatitis 1.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_hepatomegaly 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_jaundice 1.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_liver disease 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_liver fatty 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_liver function tests abnormal 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity LDH Increase - Activity Score nan None 10.2174/1570163043334794
None Hepatotoxicity LDH Increase - Index Value 0.0 None 10.2174/1570163043334794
None Hepatotoxicity LDH Increase - Number of Reports 4.0 None 10.2174/1570163043334794
None Hepatotoxicity SGOT Increase - Activity Score nan None 10.2174/1570163043334794
None Hepatotoxicity SGOT Increase - Index Value 0.2 None 10.2174/1570163043334794
None Hepatotoxicity SGOT Increase - Number of Reports 4.0 None 10.2174/1570163043334794
None Hepatotoxicity SGPT Increase - Activity Score nan None 10.2174/1570163043334794
None Hepatotoxicity SGPT Increase - Index Value 0.0 None 10.2174/1570163043334794
None Hepatotoxicity SGPT Increase - Number of Reports 4.0 None 10.2174/1570163043334794
None NON-PROTEIN TARGET Fu 0.12 None 10.1124/dmd.108.020479
None NON-PROTEIN TARGET Hepatotoxicity (acute) 0.0 % 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (animal toxicity known) nan None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (benign tumour) 0.0 None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (granulomatous hepatitis) 0.0 None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (mechanism) nan None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (moderate) 8.0 None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (moderate) 29.1 % 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (time to onset) nan None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET MBC 2.0 ug ml-1 10.1128/aac.01247-08
None NON-PROTEIN TARGET MBC 4.0 ug ml-1 10.1128/aac.01247-08
None NON-PROTEIN TARGET MBC 8.0 ug ml-1 10.1128/aac.01247-08
None NON-PROTEIN TARGET MBC90 8.0 ug ml-1 10.1128/aac.01247-08
None NON-PROTEIN TARGET MIC 0.06 ug.mL-1 10.1128/aac.01129-07
None NON-PROTEIN TARGET MIC 0.125 ug.mL-1 10.1128/aac.01247-08
None NON-PROTEIN TARGET MIC 0.25 ug.mL-1 10.1128/aac.01052-07
None NON-PROTEIN TARGET MIC 0.25 ug.mL-1 10.1128/aac.01247-08
None NON-PROTEIN TARGET MIC 0.5 ug.mL-1 10.1128/aac.00791-09
None NON-PROTEIN TARGET MIC 0.5 ug.mL-1 10.1128/aac.01247-08
None NON-PROTEIN TARGET MIC 1.0 ug.mL-1 10.1128/aac.01052-07
None NON-PROTEIN TARGET MIC 2.0 ug.mL-1 10.1128/aac.01152-06
None NON-PROTEIN TARGET MIC 4.0 ug.mL-1 10.1128/aac.01052-07
None NON-PROTEIN TARGET MIC 16.0 ug.mL-1 10.1128/aac.00128-10
None NON-PROTEIN TARGET MIC 64.0 ug.mL-1 10.1128/aac.00128-10
None NON-PROTEIN TARGET MIC 64.0 ug.mL-1 10.1128/aac.00791-09
None NON-PROTEIN TARGET MIC 64.0 ug.mL-1 10.1128/aac.01463-07
None NON-PROTEIN TARGET MIC 256.0 ug.mL-1 10.1128/aac.01284-08
None NON-PROTEIN TARGET MIC 512.0 ug.mL-1 10.1128/aac.01600-06
None NON-PROTEIN TARGET MIC50 0.125 ug.mL-1 10.1128/aac.01129-07
None NON-PROTEIN TARGET MIC90 0.25 ug.mL-1 10.1128/aac.01129-07
None NON-PROTEIN TARGET MIC90 0.25 ug.mL-1 10.1128/aac.01247-08
None No relevant target Peff 2.7 10'-6 cm/s 10.1021/acsmedchemlett.9b00071
None Unchecked Activity 0.005 % 10.1128/aac.00684-07
None Unchecked Activity 0.01 % 10.1128/aac.01164-08
None Unchecked Activity 3.0 U/mg 10.1128/aac.01283-09
None Unchecked Activity 5.0 U/mg 10.1128/aac.01283-09
None Unchecked Activity 6.0 U/mg 10.1128/aac.01283-09
None Unchecked Activity 12.0 U/mg 10.1128/aac.01283-09
None Unchecked Activity 18.0 U/mg 10.1128/aac.01283-09
None Unchecked Activity 882.0 U/mg 10.1128/aac.01283-09
None Unchecked Activity 1453.0 U/mg 10.1128/aac.01283-09
None Unchecked Activity 1522.0 U/mg 10.1128/aac.01283-09
None Unchecked Activity 1615.0 U/mg 10.1128/aac.01283-09
None Unchecked Activity 1735.0 U/mg 10.1128/aac.01283-09
None Unchecked Activity nan None 10.1128/aac.01145-07
None Unchecked FC 100.0 None 10.1128/aac.00537-07
None Unchecked Hepatotoxicity (acute) 1.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (association with vascular disease) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (choleostasis) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (chronic liver disease) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (cirrhosis) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (comment) nan None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (cytolytic) 1.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (malignant tumour) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (severe hepatitis) 1.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (steatosis) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (successful reintroduction) nan None 10.1016/s0399-8320(04)95062-2
None Unchecked IC50 0.002 ug.mL-1 10.1128/aac.01566-08
None Unchecked IC50 0.004 ug.mL-1 10.1128/aac.01566-08
None Unchecked IC50 0.008 ug.mL-1 10.1128/aac.01566-08
None Unchecked IC50 0.009 ug.mL-1 10.1128/aac.01566-08
None Unchecked IC50 0.01 ug.mL-1 10.1128/aac.01566-08
None Unchecked IC50 0.011 ug.mL-1 10.1128/aac.01566-08
None Unchecked IC50 0.016 ug.mL-1 10.1128/aac.01566-08
None Unchecked IC50 0.021 ug.mL-1 10.1128/aac.01566-08
None Unchecked IC50 0.023 ug.mL-1 10.1128/aac.01566-08
None Unchecked IC50 0.024 ug.mL-1 10.1128/aac.01566-08
None Unchecked IC50 0.028 ug.mL-1 10.1128/aac.01566-08
None Unchecked IC50 0.032 ug.mL-1 10.1128/aac.01566-08
None Unchecked IC50 0.038 ug.mL-1 10.1128/aac.01566-08
None Unchecked IC50 0.047 ug.mL-1 10.1128/aac.01566-08
None Unchecked IC50 0.048 ug.mL-1 10.1128/aac.01566-08
None Unchecked IC50 0.071 ug.mL-1 10.1128/aac.01566-08
None Unchecked IC50 0.075 ug.mL-1 10.1128/aac.01566-08
None Unchecked IC50 0.198 ug.mL-1 10.1128/aac.01566-08
None Unchecked IC50 0.923 ug.mL-1 10.1128/aac.01566-08
None Unchecked IC50 nan None 10.1128/aac.01566-08
None Unchecked Kcat 0.01 /s 10.1128/aac.00387-08
None Unchecked Kcat 0.01 /s 10.1128/aac.01164-08
None Unchecked Kcat 0.042 /s 10.1128/aac.01252-09
None Unchecked Kcat 0.05 /s 10.1128/aac.01600-06
None Unchecked Kcat 0.15 /s 10.1128/aac.01252-09
None Unchecked Kcat 0.9 /s 10.1128/aac.00858-10
None Unchecked Kcat 1.8 /s 10.1128/aac.00684-07
None Unchecked Kcat 5.3 /s 10.1128/aac.00017-09
None Unchecked Kcat 8.0 /s 10.1128/aac.00774-09
None Unchecked Kcat 8.0 /s 10.1128/aac.00858-10
None Unchecked Kcat 8.0 /s 10.1128/aac.01336-09
None Unchecked Kcat 9.0 /s 10.1128/aac.00961-09
None Unchecked Kcat 15.0 /s 10.1128/aac.01336-09
None Unchecked Kcat 66.0 /s 10.1128/aac.00163-08
None Unchecked Kcat 325.0 /s 10.1128/aac.00166-08
None Unchecked Kcat 400.0 /s 10.1128/aac.01062-07
None Unchecked Kcat/Km 0.22 /s/microM 10.1128/aac.00774-09
None Unchecked Kcat/Km 0.22 uM/hr 10.1128/aac.01336-09
None Unchecked Kcat/Km 0.4 /s/microM 10.1128/aac.00017-09
None Unchecked Kcat/Km 0.89 /s/M 10.1128/aac.01025-07
None Unchecked Kcat/Km 1.0 10'6/M/s 10.1128/aac.01252-09
None Unchecked Kcat/Km 1.3 10'5/M/s 10.1128/aac.00858-10
None Unchecked Kcat/Km 2.2 10'5/M/s 10.1128/aac.00858-10
None Unchecked Kcat/Km 3.6 10'6/M/s 10.1128/aac.01062-07
None Unchecked Kcat/Km 3.7 uM/hr 10.1128/aac.01336-09
None Unchecked Kcat/Km 3.8 10'6/M/s 10.1128/aac.01252-09
None Unchecked Kcat/Km 4.5 10'5/M/s 10.1128/aac.00684-07
None Unchecked Kcat/Km 5.0 10'5/M/s 10.1128/aac.01062-07
None Unchecked Kcat/Km 7.7 /uM/s 10.1128/aac.00166-08
None Unchecked Kcat/Km 50.0 /mM/s 10.1128/aac.01082-06
None Unchecked Kcat/Km 410.0 /mM/s 10.1128/aac.00961-09
None Unchecked Kcat/Km 410.0 /uM/s 10.1128/aac.00163-08
None Unchecked Kcat/Km nan None 10.1128/aac.00387-08
None Unchecked Km 1.1 nM 10.1128/aac.01252-09
None Unchecked Km 150.0 nM 10.1128/aac.01252-09
None Unchecked Km 4000.0 nM 10.1128/aac.01336-09
None Unchecked Km 7000.0 nM 10.1128/aac.00858-10
None Unchecked Km 37000.0 nM 10.1128/aac.00774-09
None Unchecked Km 37000.0 nM 10.1128/aac.00858-10
None Unchecked Km 37000.0 nM 10.1128/aac.01336-09
None Unchecked Km 42000.0 nM 10.1128/aac.00166-08
None Unchecked Km 110000.0 nM 10.1128/aac.01062-07
None Unchecked Km 160000.0 nM 10.1128/aac.00163-08
None Unchecked Km 400000.0 nM 10.1128/aac.00684-07
None Unchecked Km 650000.0 nM 10.1128/aac.01600-06
None Unchecked Km 1000000.0 nM 10.1128/aac.00961-09
None Unchecked Km 2000000.0 nM 10.1128/aac.01082-06
None Unchecked Km nan None 10.1128/aac.00387-08
None Unchecked Km nan None 10.1128/aac.01164-08
None Unchecked MIC 1.11 ug.mL-1 10.1021/jm00388a003
None Unchecked MIC 10.64 ug.mL-1 10.1021/jm00388a003
None Unchecked Ratio 0.08 /mM/s 10.1128/aac.01600-06
None Unchecked Ratio 4.0 None 10.1128/aac.00614-07
None Unchecked Ratio 300.0 None 10.1128/aac.00859-09

Metabolism Information