Aicar
AlkaPlorer ID: AK023777
Synonym: None
IUPAC Name: [(2R,3S,4R,5R)-5-(5-amino-4-carbamoylimidazol-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl dihydrogen phosphate
Structure
SMILES: NC(=O)C1=C(N)N([C@@H]2O[C@H](COP(=O)(O)O)[C@@H](O)[C@H]2O)C=N1
InChI: InChI=1S/C9H15N4O8P/c10-7-4(8(11)16)12-2-13(7)9-6(15)5(14)3(21-9)1-20-22(17,18)19/h2-3,5-6,9,14-15H,1,10H2,(H2,11,16)(H2,17,18,19)/t3-,5-,6-,9-/m1/s1
InChIKey: NOTGFIUVDGNKRI-UUOKFMHZSA-N
Source
| Species | Genus | Family | Order | Class | Phylum | Kingdom | Domain |
|---|---|---|---|---|---|---|---|
| Homo sapiens | Homo | Hominidae | Primates | Mammalia | Chordata | Metazoa | Eukaryota |
| Arabidopsis thaliana | Arabidopsis | Brassicaceae | Brassicales | Magnoliopsida | Streptophyta | Viridiplantae | Eukaryota |
| Mus musculus | Mus | Muridae | Rodentia | Mammalia | Chordata | Metazoa | Eukaryota |
| Escherichia coli | Escherichia | Enterobacteriaceae | Enterobacterales | Gammaproteobacteria | Pseudomonadota | None | Bacteria |
Properties Information
Molecule Weight: 338.213
TPSA？: 203.38
MolLogP？: -2.707299999999999
Number of H-Donors: 6
Number of H-Acceptors: 9
RingCount: 2
Activities Information
| Organism | Target Name | Standard Type | Standard Value | Standard Units | doi |
|---|---|---|---|---|---|
| Homo sapiens | 23132-87 | IC50 | 2832658.64 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | 5637 | IC50 | 5856280.77 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | 639-V | IC50 | 2292098.38 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | 647-V | IC50 | 5128487.19 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | 697 | IC50 | 482860.6 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | 769-P | IC50 | 10659075.84 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | 786-0 | IC50 | 1078836.04 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | 8305C | IC50 | 4299603.12 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | 8505C | IC50 | 3094513.55 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | 8-MG-BA | IC50 | 16152788.88 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | A101D | IC50 | 3817347.16 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | A 172 | IC50 | 7387192.23 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | A204 | IC50 | 6763893.74 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | A2058 | IC50 | 12934416.71 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | A2780 | IC50 | 1858987.01 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | A-375 | IC50 | 5494671.04 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | A388 | IC50 | 2634234.75 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | A3-KAW | IC50 | 367755.75 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | A-427 | IC50 | 9503096.77 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | A-431 | IC50 | 10711786.97 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | A498 | IC50 | 15811439.88 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | A4-Fuk | IC50 | 297217.44 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | A549 | IC50 | 30711148.16 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | A673 | IC50 | 2592590.89 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | A704 | IC50 | 2534604.78 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | ABC-1 | IC50 | 32281771.5 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | ACHN | IC50 | 1211928.29 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | ACN | IC50 | 1884773.63 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | AGS | IC50 | 5480408.93 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | AICAR transformylase | IC50 | 25000.0 | nM | 10.1021/jm990323+ |
| Homo sapiens | AICAR transformylase | Km | 1900.0 | nM | 10.1074/jbc.m607293200 |
| Homo sapiens | ALL-PO | IC50 | 755483.54 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | AM-38 | IC50 | 1034179.87 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | AN3-CA | IC50 | 8292344.34 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | ASPC1 | IC50 | 1327297.24 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | ATN-1 | IC50 | 412091.74 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | AU565 | IC50 | 357108.62 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | BALL-1 | IC50 | 8253519.55 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | BB30-HNC | IC50 | 213863.08 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | BB49-HNC | IC50 | 7773649.31 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | BB65-RCC | IC50 | 1195817.1 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | BCPAP | IC50 | 733333.08 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | BE-13 | IC50 | 364528.96 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | Becker | IC50 | 33786716.46 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | BEN | IC50 | 3167645.99 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | BFTC-905 | IC50 | 2128679.26 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | BFTC-909 | IC50 | 5203022.57 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | BHT-101 | IC50 | 2405483.01 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | BHY | IC50 | 404929.91 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | BPH-1 | IC50 | 1560290.03 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | BT-20 | IC50 | 1395942.37 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | BT-474 | IC50 | 13676988.12 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | BT-549 | IC50 | 806508.15 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | BV-173 | IC50 | 93837.45 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | BXPC-3 | IC50 | 1350128.43 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | C2BBe1 | IC50 | 596993.37 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | C32 | IC50 | 188576115.48 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | C-33-A | IC50 | 34795035.59 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | C3A | IC50 | 11074251.41 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | C8166 | IC50 | 1170550.0 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | Ca9-22 | IC50 | 1257769.26 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | CAKI-1 | IC50 | 2926170.94 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | CAL-120 | IC50 | 838490.29 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | CAL-12T | IC50 | 668136.17 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | CAL-27 | IC50 | 2638561.07 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | CAL-33 | IC50 | 1313117.03 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | CAL-39 | IC50 | 2731540.46 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | CAL-51 | IC50 | 192669969.2 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | CAL-54 | IC50 | 7510715.4 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | CAL-62 | IC50 | 2416249.93 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | CAL-72 | IC50 | 320718.25 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | CAL-85-1 | IC50 | 175353462.22 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | Calu-3 | IC50 | 1916172.53 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | Calu-6 | IC50 | 732451.41 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | CAMA-1 | IC50 | 353618.62 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | CAPAN-1 | IC50 | 6850596.45 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | Capan-2 | IC50 | 2303214.42 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | CaR-1 | IC50 | 1646656.26 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | CAS-1 | IC50 | 4292136.9 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | Ca-Ski | IC50 | 4598373.81 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | Caspase-3 | Activity | nan | None | 10.1021/jm060836y |
| Homo sapiens | Caspase-9 | Activity | nan | None | 10.1021/jm060836y |
| Homo sapiens | CCRF-CEM | IC50 | 11339279.06 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | CFPAC-1 | IC50 | 1123237.03 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | CGTH-W-1 | IC50 | 2058877.07 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | ChaGo-K-1 | IC50 | 1384514.76 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | CHL-1 | IC50 | 5066983.76 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | CHP-212 | IC50 | 182054250.26 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | COLO-320-HSR | IC50 | 772292.22 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | COLO-668 | IC50 | 21325802.42 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | COLO-678 | IC50 | 25136694.76 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | COLO-679 | IC50 | 179742221.38 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | COLO-680N | IC50 | 13808491.39 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | COLO-684 | IC50 | 894094.08 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | COLO-741 | IC50 | 2543079.43 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | COLO-792 | IC50 | 10363600.56 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | COLO-800 | IC50 | 12782508.6 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | COLO-824 | IC50 | 1129628.39 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | COLO-829 | IC50 | 7173557.68 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | COR-L105 | IC50 | 3867315.98 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | COR-L23 | IC50 | 727930.08 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | CP50-MEL-B | IC50 | 21811922.44 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | CP66-MEL | IC50 | 6053742.77 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | CTB-1 | IC50 | 646364.77 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | CTV-1 | IC50 | 265881.84 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | CW-2 | IC50 | 6372429.03 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | CWR22R | IC50 | 9228594.12 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | D-247MG | IC50 | 15416937.17 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | D-263MG | IC50 | 21585757.47 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | D283 Med | IC50 | 5575420.39 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | D-336MG | IC50 | 164885405.59 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | D-392MG | IC50 | 15019445.39 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | D-423MG | IC50 | 2904422.92 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | D-502MG | IC50 | 24253494.76 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | D-542MG | IC50 | 142254786.51 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | D-566MG | IC50 | 2539727.32 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | Daoy | IC50 | 1505266.14 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | DB | IC50 | 91254.2 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | DBTRG-05MG | IC50 | 1287737.39 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | DEL | IC50 | 231581.99 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | Detroit 562 | IC50 | 1216819.78 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | DJM-1 | IC50 | 36288022.24 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | DK-MG | IC50 | 175204124.7 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | DMS-114 | IC50 | 1579271.59 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | DMS-273 | IC50 | 14159683.28 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | DMS-79 | IC50 | 8858094.92 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | DOHH-2 | IC50 | 1313009.36 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | DOK | IC50 | 657350.26 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | DoTc2-4510 | IC50 | 1254454.38 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | DSH1 | IC50 | 10199734.81 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | DU-145 | Activity | 28.0 | % | 10.1021/jm060836y |
| Homo sapiens | DU-145 | Activity | 34.0 | % | 10.1021/jm060836y |
| Homo sapiens | DU-145 | IC50 | 59000.0 | nM | 10.1021/jm060836y |
| Homo sapiens | DU-145 | IC50 | 6767202.09 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | EC-GI-10 | IC50 | 3927926.67 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | EFM-19 | IC50 | 343231.45 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | EFO-21 | IC50 | 8386201.87 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | EFO-27 | IC50 | 1675381.2 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | EGI-1 | IC50 | 29401295.0 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | EKVX | IC50 | 2595369.05 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | EM-2 | IC50 | 229736.96 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | EPLC-272H | IC50 | 568874.02 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | ES1 | IC50 | 5818687.5 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | ES3 | IC50 | 1101080.23 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | ES4 | IC50 | 1773279.61 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | ES5 | IC50 | 4407244.75 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | ES6 | IC50 | 22220043.04 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | ES7 | IC50 | 2380883.7 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | ES8 | IC50 | 5115441.55 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | ESS-1 | IC50 | 2000843.26 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | ETK-1 | IC50 | 541373.27 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | EW-1 | IC50 | 1869529.36 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | EW-11 | IC50 | 1085818.11 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | EW-13 | IC50 | 2894619.65 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | EW-16 | IC50 | 51559924.87 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | EW-18 | IC50 | 4015880.88 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | EW-22 | IC50 | 7184972.71 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | EW-24 | IC50 | 13384987.2 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | FaDu | IC50 | 1064813.56 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | Fructose-1,6-bisphosphatase | Activity | nan | None | 10.1021/jm900078f |
| Homo sapiens | Fructose-1,6-bisphosphatase | ED50 | 250.0 | uM | 10.1021/jm900078f |
| Homo sapiens | Fructose-1,6-bisphosphatase | IC50 | 12000.0 | nM | 10.1016/j.ejmech.2017.09.029 |
| Homo sapiens | Fructose-1,6-bisphosphatase | IC50 | 12000.0 | nM | 10.1021/jm900078f |
| Homo sapiens | FTC-133 | IC50 | 116604016.6 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | G-361 | IC50 | 243577878.51 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | G-401 | IC50 | 31694549.34 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | G-402 | IC50 | 1322446.88 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | GAK | IC50 | 83526063.51 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | GAMG | IC50 | 2274564.76 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | GB-1 | IC50 | 9785832.94 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | GCIY | IC50 | 173281202.18 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | GCT | IC50 | 1386651.32 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | GI-1 | IC50 | 105604789.04 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | GI-ME-N | IC50 | 29640175.49 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | GMS-10 | IC50 | 663077.58 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | GOTO | IC50 | 4488348.07 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | GP5d | IC50 | 1772394.97 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | GR-ST | IC50 | 430965.48 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | GT3TKB | IC50 | 9582166.56 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | H4 | IC50 | 40743720.15 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | HAL-01 | IC50 | 434344.07 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | HC-1 | IC50 | 1162424.28 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | HCC1187 | IC50 | 1142651.82 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | HCC1395 | IC50 | 22254666.59 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | HCC1419 | IC50 | 3132137.63 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | HCC1569 | IC50 | 994099.2 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | HCC1806 | IC50 | 360641.36 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | HCC1937 | IC50 | 3518359.12 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | HCC1954 | IC50 | 2019521.74 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | HCC 2998 | IC50 | 13835859.29 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | HCC38 | IC50 | 6146235.13 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | HCC70 | IC50 | 1265886.57 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | HCE-4 | IC50 | 1706305.87 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | HCE-T | IC50 | 715290.68 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | HCT-116 | IC50 | 423891.7 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | HCT-15 | IC50 | 1891854.8 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | HDLM-2 | IC50 | 1781696.0 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | HD-MY-Z | IC50 | 1954977.57 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | Heat shock protein HSP90 | Activity | 70.0 | % | 10.1021/jm060836y |
| Homo sapiens | HEC-1 | IC50 | 12192472.11 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | HEL | IC50 | 803633.24 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | HeLa | Activity | 23.0 | % | 10.1021/jm060836y |
| Homo sapiens | HeLa | Activity | 27.0 | % | 10.1021/jm060836y |
| Homo sapiens | HeLa | IC50 | 126000.0 | nM | 10.1021/jm060836y |
| Homo sapiens | H-EMC-SS | IC50 | 124614344.11 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | HGC-27 | IC50 | 1319581.61 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | HH | IC50 | 232426.02 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | HL-60 | IC50 | 375546.76 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | HLE | IC50 | 2077469.82 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | HMV-2 cell line | IC50 | 2229833.06 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | HN | IC50 | 252030.22 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | HO-1-N-1 | IC50 | 792708.85 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | HOP-62 | IC50 | 39263436.66 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | HOP-92 | IC50 | 1693737.66 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | HOS | IC50 | 2553741.97 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | HPAF-II | IC50 | 7270482.96 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | Hs-578T | IC50 | 14172106.77 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | HSC-2 | IC50 | 845513.39 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | HSC-3 | IC50 | 258596.78 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | HSC-4 | IC50 | 874475.26 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | HT | IC50 | 995100.76 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | HT-1080 | IC50 | 2313394.02 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | HT1197 | IC50 | 92043355.46 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | HT-1376 | IC50 | 2862959.04 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | HT-144 | IC50 | 4436548.55 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | HT-29 | IC50 | 5277712.27 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | HT-3 | IC50 | 472094.89 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | HT55 | IC50 | 48745686.97 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | HTC-C3 | IC50 | 252027.45 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | HuCCT-1 | IC50 | 1083067.96 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | Huh-7 | IC50 | 7675356.34 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | HuO-3N1 | IC50 | 89364.72 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | HuO9 | IC50 | 1966632.56 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | HuP-T3 | IC50 | 1346347.97 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | HuP-T4 | IC50 | 15227769.79 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | HuTu80 | IC50 | 21986699.91 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | IA-LM | IC50 | 859282.72 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | IGR-1 | IC50 | 4148586.7 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | IGROV-1 | IC50 | 65812824.53 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | IST-MEL1 | IC50 | 6346336.52 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | IST-MES1 | IC50 | 132994359.96 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | IST-SL1 | IC50 | 20583334.04 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | J82 | IC50 | 17553137.71 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | JAR | IC50 | 345921.89 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | JEG-3 | IC50 | 1437526.2 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | J-RT3-T3-5 | IC50 | 3294431.84 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | JVM-2 | IC50 | 18098765.31 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | JVM-3 | IC50 | 2785885.35 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | K5 | IC50 | 23348849.74 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | K562 | IC50 | 3343010.41 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | KALS-1 | IC50 | 1157541.92 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | KARPAS-299 | IC50 | 31487565.47 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | KARPAS-45 | IC50 | 1409361.44 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | KE-37 | IC50 | 534465.4 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | KG-1 | IC50 | 300947.85 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | KGN | IC50 | 630426.14 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | KINGS-1 | IC50 | 11599195.25 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | KLE | IC50 | 171301424.48 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | KM12 | IC50 | 4650202.29 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | KM-H2 | IC50 | 1169348.46 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | KMOE-2 | IC50 | 415046.68 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | KNS-42 | IC50 | 2915416.59 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | KNS-62 | IC50 | 995822.47 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | KNS-81-FD | IC50 | 37523399.35 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | KOSC-2 | IC50 | 526411.38 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | KP-4 | IC50 | 52806681.22 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | KP-N-YN | IC50 | 2463361.11 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | KP-N-YS | IC50 | 2771658.07 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | KS-1 | IC50 | 1254813.21 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | KU-19-19 | IC50 | 2190451.57 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | KURAMOCHI | IC50 | 8210088.65 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | KYSE-140 | IC50 | 1732720.51 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | KYSE-150 cell line | IC50 | 1006639.67 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | KYSE-180 | IC50 | 453173.02 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | KYSE-270 | IC50 | 21823289.41 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | KYSE-410 | IC50 | 14860411.36 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | KYSE-450 | IC50 | 1298886.97 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | KYSE-510 | IC50 | 905338.58 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | KYSE-520 cell line | IC50 | 382100.25 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | KYSE-70 cell line | IC50 | 3487672.89 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | L-363 | IC50 | 178988.76 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | L-428 | IC50 | 14156780.85 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | LAMA-84 | IC50 | 435152.7 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | LAN-6 | IC50 | 153001652.35 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | LB1047-RCC | IC50 | 9598969.23 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | LB2241-RCC | IC50 | 1372987.09 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | LB2518-MEL | IC50 | 44670160.17 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | LB373-MEL-D | IC50 | 5636423.43 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | LB771-HNC | IC50 | 6673708.62 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | LB831-BLC | IC50 | 6276783.83 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | LC-2-ad | IC50 | 1172199.29 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | LCLC-103H cell line | IC50 | 1368373.38 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | LCLC-97TM1 | IC50 | 917334.33 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | LK-2 | IC50 | 3112734.88 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | LN-405 | IC50 | 42630788.25 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | LNCaP-Clone-FGC | IC50 | 8310582.65 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | LoVo | IC50 | 4442159.9 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | LOX IMVI | IC50 | 928970.52 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | LS-1034 | IC50 | 43839871.92 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | LS-123 | IC50 | 690432.35 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | LS-411N | IC50 | 3762902.95 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | LS-513 | IC50 | 10951842.65 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | LU-134-A | IC50 | 958812.94 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | LU-135 | IC50 | 12481814.2 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | LU-139 | IC50 | 803363.27 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | Lu-65 | IC50 | 16969196.35 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | LU-99A | IC50 | 31890167.1 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | LXF-289 cell line | IC50 | 201339335.52 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | M059J | IC50 | 2225293.29 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | M14 | IC50 | 294674.39 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | MC116 | IC50 | 1290250.93 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | MCF7 | IC50 | 900511.56 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | MC-IXC | IC50 | 1777398.4 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | MDA-MB-157 | IC50 | 1212084.64 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | MDA-MB-175-VII | IC50 | 21831431.01 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | MDA-MB-231 | IC50 | 3665833.46 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | MDA-MB-361 | IC50 | 1305033.51 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | MDA-MB-415 | IC50 | 654764.09 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | MDA-MB-453 | IC50 | 2299746.09 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | ME-180 | IC50 | 415591.16 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | MEG-01 | IC50 | 447177.68 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | MEL-HO | IC50 | 396797.87 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | MEL-JUSO | IC50 | 74107498.46 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | MeWo | IC50 | 2197892.0 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | MFE-280 | IC50 | 87526597.71 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | MFH-ino | IC50 | 104194539.2 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | MFM-223 | IC50 | 1156530.67 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | MG-63 | IC50 | 2010627.22 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | MHH-ES-1 | IC50 | 1508763.92 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | MHH-NB-11 | IC50 | 1113831.33 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | MHH-PREB-1 | IC50 | 416430.26 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | MIA PaCa-2 | IC50 | 9186065.54 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | MKN-1 | IC50 | 17939459.38 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | MKN-28 | IC50 | 5865992.67 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | MKN-45 | IC50 | 84388549.34 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | MKN-7 | IC50 | 2059674.01 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | ML-2 | IC50 | 3987074.37 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | MLMA | IC50 | 374746.58 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | MMAC-SF | IC50 | 31328327.53 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | MN-60 | IC50 | 64640472.31 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | Mo | IC50 | 2369710.32 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | MOLT-16 | IC50 | 3451861.74 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | MOLT-4 | IC50 | 484562.3 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | MPP-89 | IC50 | 96154735.41 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | MS-1 | IC50 | 425407.7 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | MSTO-211H | IC50 | 1736276.23 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | MV4-11 | IC50 | 107965.21 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | MZ1-PC | IC50 | 2891824.8 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | MZ2-MEL | IC50 | 2251716.29 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | MZ7-mel | IC50 | 1770846.57 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NB10 | IC50 | 52097487.4 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NB12 | IC50 | 58835459.21 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NB13 | IC50 | 102340114.38 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NB14 | IC50 | 1446462.21 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NB17 | IC50 | 4432464.37 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NB5 | IC50 | 3898363.0 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NB6 | IC50 | 22389379.59 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NB69 | IC50 | 975958.44 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NB7 | IC50 | 900690.78 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NBsusSR | IC50 | 473868.57 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H1048 | IC50 | 6962709.68 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H1092 | IC50 | 1220995.76 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H1155 | IC50 | 800191.44 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H1299 | IC50 | 5792759.18 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H1304 | IC50 | 4209478.3 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H1355 | IC50 | 4084232.06 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H1395 | IC50 | 68166464.5 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H1437 | IC50 | 598939.15 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H1563 | IC50 | 247832898.09 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H1573 | IC50 | 352578.75 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H1581 | IC50 | 3395797.78 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H1623 | IC50 | 9288227.34 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H1648 | IC50 | 2211353.39 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H1650 | IC50 | 3675038.91 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H1651 | IC50 | 15667942.11 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H1666 | IC50 | 3679157.26 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H1693 | IC50 | 2674955.44 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H1703 | IC50 | 2488879.78 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H1755 | IC50 | 1840751.15 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H1770 | IC50 | 485363.45 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H1792 | IC50 | 1593576.28 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H1793 | IC50 | 3080761.24 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H1838 | IC50 | 57002704.9 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H1975 | IC50 | 1071537.7 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H1993 | IC50 | 253391499.37 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H2009 | IC50 | 1460678.01 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H2029 | IC50 | 167678376.85 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H2030 | IC50 | 1512404.43 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H2052 | IC50 | 1485686.15 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H2087 | IC50 | 4231928.17 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H209 | IC50 | 3220307.08 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H2122 | IC50 | 506774.43 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H2126 | IC50 | 2570230.85 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H2170 | IC50 | 28616592.9 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H2228 | IC50 | 1947225.85 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H226 | IC50 | 9432778.72 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H2291 | IC50 | 8461383.72 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H23 | IC50 | 19878400.12 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H2342 | IC50 | 2534931.77 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H2347 | IC50 | 3683847.5 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H2405 | IC50 | 48039938.69 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H2452 | IC50 | 4087635.65 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H28 | IC50 | 1043232.14 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H292 | IC50 | 22036798.63 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H358 | IC50 | 5050052.91 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H441 | IC50 | 2173728.12 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H446 | IC50 | 25495825.2 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H460 | IC50 | 1357100.88 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H510A | IC50 | 14205961.79 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H520 | IC50 | 744314.75 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H526 | IC50 | 115422.46 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H596 | IC50 | 4187670.95 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H630 | IC50 | 2970225.04 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H650 | IC50 | 7470222.03 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H661 | IC50 | 2234542.97 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H727 | IC50 | 38968269.84 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H747 | IC50 | 1647130.56 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H810 | IC50 | 13514845.14 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H82 | IC50 | 993131.42 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-N87 | IC50 | 1488085.99 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NEC8 | IC50 | 95717650.87 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NH-12 | IC50 | 10803322.45 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NKM-1 | IC50 | 179661.94 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NMC-G1 | IC50 | 10729325.79 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | no-10 | IC50 | 22673633.31 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | no-11 | IC50 | 10048593.97 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NOMO-1 | IC50 | 847363.7 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NOS-1 | IC50 | 523863.94 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NTERA-2-cl-D1 | IC50 | 33877081.41 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NUGC-3 | IC50 | 3397275.28 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NY | IC50 | 494610.21 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | OAW-28 | IC50 | 179150945.42 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | OAW-42 | IC50 | 26362557.34 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | OC-314 | IC50 | 124040573.91 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | OCI-AML2 | IC50 | 1149939.95 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | OCUB-M | IC50 | 1189482.95 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | OE19 | IC50 | 5381928.25 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | OE33 | IC50 | 1327886.69 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | OMC-1 | IC50 | 3647488.03 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | ONS-76 | IC50 | 50972675.83 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | OS-RC-2 | IC50 | 2910703.26 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | OVCAR-3 | IC50 | 23016462.51 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | OVCAR-4 | IC50 | 750593.33 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | OVCAR-5 | IC50 | 50814092.17 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | OVCAR-8 | IC50 | 6163370.09 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | P12-Ichikawa | IC50 | 1473053.89 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | P30-OHK | IC50 | 541245.52 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | PA-1 | IC50 | 856047.62 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | PANC-03-27 | IC50 | 4784768.87 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | PANC-08-13 | IC50 | 1297067.21 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | Panc1005 | IC50 | 3380480.03 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | PC-14 | IC50 | 379380.63 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | PC-3 | IC50 | 349065.99 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | PFSK-1 | IC50 | 8262545.57 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | PSN1 | IC50 | 1950357.56 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | QIMR-WIL | IC50 | 485950.61 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | Ramos-2G6-4C10 | IC50 | 238217.95 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | RCC10RGB | IC50 | 60359220.58 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | RCM-1 | IC50 | 17958664.87 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | RD | IC50 | 59065838.06 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | RERF-LC-MS | IC50 | 112629618.29 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | RH-1 | IC50 | 2461209.07 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | RH-18 | IC50 | 3553264.37 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | RKO | IC50 | 829710.63 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | RMG-I | IC50 | 71054466.8 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | RO82-W-1 | IC50 | 7996586.16 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | RPMI-2650 | IC50 | 101508010.95 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | RPMI-7951 | IC50 | 1582254.49 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | RPMI-8226 | IC50 | 501411.94 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | RPMI-8866 | IC50 | 2763319.63 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | RS4-11 | IC50 | 350996.41 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | RT-112 | IC50 | 1873249.68 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | RVH-421 | IC50 | 11434529.96 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | RXF 393 | IC50 | 709935.41 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | S-117 | IC50 | 3132469.66 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SAOS-2 | IC50 | 11887669.91 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SAS | IC50 | 746450.27 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SBC-1 | IC50 | 1397913.43 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SBC-5 | IC50 | 1477001.06 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SCC-15 | IC50 | 466201.53 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SCC-25 | IC50 | 1228685.28 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SCC-4 | IC50 | 1227622.93 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SCC-9 | IC50 | 10225378.53 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SCH | IC50 | 2691696.65 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SF-126 | IC50 | 4683242.54 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SF-268 | IC50 | 8598800.54 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SF-295 | IC50 | 200529370.24 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SF-539 | IC50 | 25395950.22 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SH-4 | IC50 | 2909838.91 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SHP77 | IC50 | 16931955.95 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SiHa | IC50 | 44445144.51 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SJSA-1 | IC50 | 948981.21 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SKG-IIIa | IC50 | 2789972.45 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SK-HEP1 | IC50 | 920252.42 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SK-LMS-1 | IC50 | 157759026.65 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SK-LU-1 | IC50 | 1697951.83 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SK-MEL-1 | IC50 | 37063279.96 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SK-MEL-2 | IC50 | 2126532.5 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SK-MEL-24 | IC50 | 49352810.82 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SK-MEL-28 | IC50 | 15780101.08 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SK-MEL3 | IC50 | 104068435.98 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SK-MEL-30 | IC50 | 9617580.45 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SK-MES-1 | IC50 | 14569010.74 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SK-N-AS | IC50 | 11992886.96 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SK-N-DZ | IC50 | 1016051.18 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SK-NEP-1 | IC50 | 611139.35 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SK-N-FI | IC50 | 209352769.42 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SK-OV-3 | IC50 | 42865560.63 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SK-PN-DW | IC50 | 740805.42 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SK-UT-1 | IC50 | 6296020.21 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SN12C | IC50 | 3045824.76 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SNB-75 | IC50 | 1395840.47 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SNU1 | IC50 | 464431.93 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SNU-387 | IC50 | 2824580.11 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SNU-423 | IC50 | 1220285.35 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SNU-449 | IC50 | 2971716.47 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SNU-5 | IC50 | 28245487.8 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SNU-C2B | IC50 | 2301356.48 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SW1088 | IC50 | 17987439.72 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SW 1116 | IC50 | 25001997.48 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SW13 | IC50 | 46836214.65 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SW1417 | IC50 | 19657063.14 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SW1463 | IC50 | 10109531.8 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SW1573 | IC50 | 28196919.12 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SW1710 | IC50 | 34962488.2 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SW1783 | IC50 | 4121197.27 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SW1990 | IC50 | 1121220.38 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SW48 | IC50 | 932199.64 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SW-620 | IC50 | 3750153.31 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SW626 | IC50 | 62108181.1 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SW684 | IC50 | 896334.8 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SW756 | IC50 | 17886669.61 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SW780 | IC50 | 2315673.84 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SW837 | IC50 | 5741811.32 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SW872 | IC50 | 78998646.63 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SW900 | IC50 | 4591417.14 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SW948 | IC50 | 35003383.25 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SW 954 | IC50 | 412406.29 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SW 962 | IC50 | 16311472.93 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SW982 | IC50 | 21503306.65 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | T-24 | IC50 | 11657872.71 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | T47D | IC50 | 412757.4 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | T84 | IC50 | 29341260.13 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | T98G | IC50 | 17410208.35 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | TCC-SUP | IC50 | 1034861.62 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | TE-1 | IC50 | 206785.29 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | TE-10 | IC50 | 1513504.35 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | TE-11 | IC50 | 587441.7 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | TE-12 | IC50 | 2826060.58 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | TE-5 | IC50 | 16071937.21 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | TE-6 | IC50 | 10931370.91 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | TE-8 | IC50 | 828469.48 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | TE-9 | IC50 | 7742314.86 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | TGBC11TKB | IC50 | 6268058.9 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | TGBC1TKB | IC50 | 814289.54 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | TGBC24TKB | IC50 | 735581.98 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | TI-73 | IC50 | 723930.22 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | TK-10 | IC50 | 16642617.44 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | TYK-nu | IC50 | 4002158.02 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | U-118-MG | IC50 | 1427441.56 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | U-251 | IC50 | 2881087.19 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | U-266 | IC50 | 7868919.2 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | U2OS | IC50 | 4017322.84 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | U-87 MG | IC50 | 3606117.54 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | UACC-257 | IC50 | 80871196.39 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | UACC-62 | IC50 | 2517659.55 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | UACC-893 | IC50 | 58365485.94 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | UMC-11 | IC50 | 3178647.27 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | UMUC3 | IC50 | 1753908.49 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | UO-31 | IC50 | 765926.34 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | VA-ES-BJ | IC50 | 819306.29 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | VM-CUB-1 | IC50 | 673037.47 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | VMRC-RCZ | IC50 | 3395889.47 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | WM-115 | IC50 | 16933107.36 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | YAPC | IC50 | 17052123.15 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | YH-13 | IC50 | 13764429.9 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | YKG-1 | IC50 | 552064.56 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | ZR-75-30 | IC50 | 3565159.24 | nM | 10.6019/CHEMBL1201861 |
| Mus musculus | 3T3-L1 | Activity | nan | None | 10.1021/acs.jmedchem.5b01566 |
| Mus musculus | Histidine triad nucleotide-binding protein 1 | Kd | 1100000.0 | nM | 10.1016/j.bmc.2010.07.051 |
| Mus musculus | Histidine triad nucleotide-binding protein 1 | Kd | 1200000.0 | nM | 10.1016/j.bmc.2010.07.051 |
| Mus musculus | P388 | ID50 | 220.0 | uM | 10.1021/jm00379a018 |
| None | ADMET | Activity | nan | None | 10.1021/jm060836y |
| None | ADMET | IC50 | 105000.0 | nM | 10.1021/jm060836y |
| None | Molecular identity unknown | Inhibition | nan | % | 10.1021/acs.jmedchem.5b01566 |
| None | Unchecked | Activity | 13.0 | % | 10.1021/jm060836y |
| None | Unchecked | Activity | 20.0 | % | 10.1021/jm060836y |
| None | Unchecked | Activity | nan | None | 10.1021/acs.jmedchem.5b01566 |
| None | Unchecked | Activity | nan | None | 10.1021/jm8008713 |
| None | Unchecked | Activity | nan | None | 10.1074/jbc.m706536200 |
| None | Unchecked | EC50 | 84000.0 | nM | 10.1021/ml100143q |
| None | Unchecked | EC50 | 115000.0 | nM | 10.1021/ml100143q |
| None | Unchecked | IC50 | 9400.0 | nM | 10.1021/ml100143q |
| None | Unchecked | Ki | nan | nM | 10.1021/jm00379a018 |