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Celecoxib

AlkaPlorer ID: AK023832

Synonym: None

IUPAC Name: 4-[5-(4-methylphenyl)-3-(trifluoromethyl)pyrazol-1-yl]benzenesulfonamide

Structure

SMILES: CC1=CC=C(C2=CC(C(F)(F)F)=NN2C2=CC=C(S(N)(=O)=O)C=C2)C=C1

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InChI: InChI=1S/C17H14F3N3O2S/c1-11-2-4-12(5-3-11)15-10-16(17(18,19)20)22-23(15)13-6-8-14(9-7-13)26(21,24)25/h2-10H,1H3,(H2,21,24,25)

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InChIKey: RZEKVGVHFLEQIL-UHFFFAOYSA-N

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Reference

PubChem CID: 2662

CAS: 1000343-91-8

SuperNatural Ⅲ: SN0339219

NPASS: NPC316910

COCONUT: CNP0337667

Properties Information

Molecule Weight: 381.3790000000001

TPSA？: 77.98

MolLogP？: 3.5139200000000006

Number of H-Donors: 1

Number of H-Acceptors: 4

RingCount: 3

Activities Information

Organism Target Name Standard Type Standard Value Standard Units doi
Acinetobacter baumannii Acinetobacter baumannii Inhibition 15.77 % 10.6019/CHEMBL4513141
Anopheles gambiae AGAP002992-PA Ki 173.0 nM 10.1016/j.bmc.2015.03.081
Astrosclera willeyana Astrosclerin-3 Ki 732.0 nM 10.1016/j.bmc.2012.01.007
Bos taurus Arachidonate 5-lipoxygenase IC50 nan None 10.1016/j.bmcl.2012.06.012
Bos taurus Carbonic anhydrase IV IC50 290.0 nM 10.1016/j.bmcl.2003.11.014
Bos taurus Carbonic anhydrase IV IC50 290.0 nM 10.1021/jm030912m
Bos taurus Carbonic anhydrase IV Ki 290.0 nM 10.1016/j.bmcl.2004.12.009
Bos taurus Carbonic anhydrase IV Ki 290.0 nM 10.1016/j.bmcl.2005.09.040
Bos taurus Cyclooxygenase-1 IC50 7700.0 nM 10.1021/jm8015188
Bos taurus Cyclooxygenase-1 IC50 8000.0 nM 10.1016/j.bmc.2008.11.074
Bos taurus Cyclooxygenase-1 IC50 8200.0 nM 10.1016/j.ejmech.2015.11.013
Bos taurus Cyclooxygenase-1 IC50 21610.0 nM 10.1016/j.ejmech.2011.08.015
Bos taurus Cyclooxygenase-1 IC50 24300.0 nM 10.1007/s00044-009-9230-8
Bos taurus Cyclooxygenase-1 IC50 nan None 10.1016/j.bmcl.2012.06.012
Bos taurus Cyclooxygenase-1 Inhibition 65.0 % 10.1016/j.ejmech.2007.09.007
Bos taurus Cyclooxygenase-2 IC50 57.0 nM 10.1021/jm0302391
Bos taurus Cyclooxygenase-2 IC50 60.0 nM 10.1007/s00044-009-9230-8
Bos taurus Progesterone receptor IC50 18109.0 nM None
Bos taurus Progesterone receptor Ki 2362.0 nM None
Brucella suis biovar 1 Carbonic anhydrase Kinact 18.0 nM 10.1021/jm901855h
Candida albicans Candida albicans Inhibition 2.46 % 10.6019/CHEMBL4513141
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) Carbonic anhydrase Ki 1017.0 nM 10.1016/j.bmc.2009.05.002
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) Carbonic anhydrase Ki 1017.0 nM 10.1021/jm300203r
Candida glabrata CBS 138 Carbonic anhydrase Ki 116.0 nM 10.1016/j.bmcl.2013.02.092
Canis lupus familiaris Canis familiaris AUC 3100.0 ng.hr.mL-1 10.1016/j.bmcl.2003.10.004
Canis lupus familiaris Canis familiaris C24 nan None 10.1016/j.bmcl.2003.10.004
Canis lupus familiaris Canis familiaris Cmax 1415.91 nM 10.1016/j.bmcl.2003.10.004
Canis lupus familiaris Canis familiaris T1/2 3.3 hr 10.1016/j.bmcl.2003.10.004
Canis lupus familiaris Canis familiaris Tmax nan hr 10.1016/j.bmcl.2003.10.004
Canis lupus familiaris Cyclooxygenase-1 IC50 5570.0 nM 10.1016/j.bmcl.2003.10.004
Canis lupus familiaris Cyclooxygenase-2 IC50 900.0 nM 10.1016/j.bmcl.2003.10.004
Cavia porcellus Leukotriene C4 synthase IC50 nan None None
Cavia porcellus Leukotriene C4 synthase Ki nan None None
Cavia porcellus Serotonin 4 (5-HT4) receptor IC50 nan None None
Cavia porcellus Serotonin 4 (5-HT4) receptor Ki nan None None
Cavia porcellus Voltage-dependent L-type calcium channel subunit alpha-1C IC50 10600.0 nM None
Chlorocebus sabaeus Vero IC50 60630.0 nM 10.1016/j.bmc.2022.116633
Cryptococcus neoformans Cryptococcus neoformans Inhibition 0.77 % 10.6019/CHEMBL4513141
Cryptococcus neoformans var. grubii Carbonic anhydrase 2 Ki 3056.0 nM 10.1021/jm300203r
Escherichia coli Escherichia coli Activity nan None 10.1128/aac.00048-09
Escherichia coli Escherichia coli Inhibition 6.38 % 10.6019/CHEMBL4513141
Homo sapiens 3-phosphoinositide dependent protein kinase-1 IC50 48000.0 nM 10.1016/j.bmcl.2011.12.121
Homo sapiens 3-phosphoinositide dependent protein kinase-1 IC50 48000.0 nM 10.1016/j.ejmech.2013.04.062
Homo sapiens 3-phosphoinositide dependent protein kinase-1 IC50 48000.0 nM None
Homo sapiens 786-0 GI50 37068.07 nM None
Homo sapiens A498 GI50 15135.61 nM None
Homo sapiens A549 GI50 14354.89 nM None
Homo sapiens A549 IC50 2150.0 nM 10.1016/j.bmcl.2015.08.026
Homo sapiens A549 IC50 7680.0 nM 10.1016/j.bmcl.2017.07.020
Homo sapiens A549 IC50 11040.0 nM 10.1016/j.ejmech.2019.03.008
Homo sapiens A549 IC50 15600.0 nM 10.1016/j.ejmech.2012.11.021
Homo sapiens A549 IC50 15640.0 nM 10.1016/j.bmcl.2016.06.037
Homo sapiens A549 IC50 16080.0 nM 10.1016/j.bmc.2018.07.022
Homo sapiens A549 IC50 16300.0 nM 10.1016/j.bmcl.2021.128240
Homo sapiens A549 IC50 17500.0 nM 10.1016/j.ejmech.2020.112439
Homo sapiens A549 IC50 57870.0 nM 10.1016/j.bmc.2022.116633
Homo sapiens A549 Inhibition 86.15 % 10.1016/j.ejmech.2020.112439
Homo sapiens Acetylcholinesterase IC50 nan None None
Homo sapiens Acetylcholinesterase Ki nan None None
Homo sapiens ACHN GI50 17538.81 nM None
Homo sapiens Adenosine A1 receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Adenosine A1 receptor IC50 nan None None
Homo sapiens Adenosine A1 receptor Ki nan None None
Homo sapiens Adenosine A2a receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Adenosine A2a receptor IC50 nan None None
Homo sapiens Adenosine A2a receptor Ki nan None None
Homo sapiens Adenosine A3 receptor AC50 9140.1 nM 10.1038/s41467-023-40064-9
Homo sapiens Adenosine A3 receptor IC50 24622.0 nM None
Homo sapiens Adenosine A3 receptor Ki 13917.0 nM None
Homo sapiens Alpha-1a adrenergic receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-1a adrenergic receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-1d adrenergic receptor IC50 nan None None
Homo sapiens Alpha-1d adrenergic receptor Ki nan None None
Homo sapiens Alpha-2a adrenergic receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-2a adrenergic receptor IC50 nan None None
Homo sapiens Alpha-2a adrenergic receptor Ki nan None None
Homo sapiens Alpha-2b adrenergic receptor AC50 1880.4 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-2b adrenergic receptor IC50 1516.0 nM None
Homo sapiens Alpha-2b adrenergic receptor Ki 692.0 nM None
Homo sapiens Alpha-2c adrenergic receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-2c adrenergic receptor IC50 nan None None
Homo sapiens Alpha-2c adrenergic receptor Ki nan None None
Homo sapiens Androgen Receptor Potency 44668.4 nM None
Homo sapiens Angiotensin II type 2 (AT-2) receptor IC50 nan None None
Homo sapiens Angiotensin II type 2 (AT-2) receptor Ki nan None None
Homo sapiens Arachidonate 12-lipoxygenase Inhibition 7.0 % 10.1016/j.bmc.2008.01.047
Homo sapiens Arachidonate 12-lipoxygenase Inhibition nan % 10.1021/jm200092b
Homo sapiens Arachidonate 15-lipoxygenase IC50 49.0 nM 10.1039/d1md00280e
Homo sapiens Arachidonate 15-lipoxygenase Inhibition nan % 10.1021/jm200092b
Homo sapiens Arachidonate 5-lipoxygenase IC50 1720.0 nM 10.1016/j.ejmech.2020.112066
Homo sapiens Arachidonate 5-lipoxygenase IC50 10000.0 nM 10.1016/j.bmcl.2022.129101
Homo sapiens Arachidonate 5-lipoxygenase IC50 10000.0 nM 10.1021/jm0407761
Homo sapiens Arachidonate 5-lipoxygenase IC50 nan None 10.1016/j.bmc.2010.04.034
Homo sapiens Arachidonate 5-lipoxygenase Inhibition 80.0 % 10.1021/jm2001376
Homo sapiens Arachidonate 5-lipoxygenase Inhibition 89.0 % 10.1016/j.bmc.2008.01.047
Homo sapiens Beta-1 adrenergic receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Beta-1 adrenergic receptor IC50 nan None None
Homo sapiens Beta-1 adrenergic receptor Ki nan None None
Homo sapiens Beta-2 adrenergic receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Beta-2 adrenergic receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Beta-2 adrenergic receptor IC50 nan None None
Homo sapiens Beta-2 adrenergic receptor Ki nan None None
Homo sapiens Beta-3 adrenergic receptor AC50 5200.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Beta-3 adrenergic receptor IC50 16124.0 nM None
Homo sapiens Beta-3 adrenergic receptor Ki 12093.0 nM None
Homo sapiens Bile salt export pump AC50 34000.1 nM 10.1038/s41467-023-40064-9
Homo sapiens Bile salt export pump IC50 133000.0 nM 10.1093/toxsci/kft176
Homo sapiens Bradykinin B1 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Bradykinin B2 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Bradykinin B2 receptor IC50 nan None None
Homo sapiens Bradykinin B2 receptor Ki nan None None
Homo sapiens BT-549 GI50 18450.15 nM None
Homo sapiens Caco-2 IC50 42740.0 nM 10.1016/j.ejmech.2018.09.007
Homo sapiens Caco-2 Papp 1.24 10'-5 cm/s 10.1016/j.bmcl.2011.09.071
Homo sapiens Caco-2 Papp 1.88 10'-4 cm/s 10.1016/j.bmcl.2011.09.071
Homo sapiens Caco-2 permeability 46.0 % 10.1016/j.bmcl.2011.09.071
Homo sapiens Caco-2 permeability 98.0 % 10.1016/j.bmcl.2011.09.071
Homo sapiens CAKI-1 GI50 19633.6 nM None
Homo sapiens Calcitonin receptor IC50 nan None None
Homo sapiens Calcitonin receptor Ki nan None None
Homo sapiens Canalicular multispecific organic anion transporter 1 Activity 46.0 % 10.1021/jm7015683
Homo sapiens Canalicular multispecific organic anion transporter 1 IC50 133000.0 nM 10.1093/toxsci/kft176
Homo sapiens Canalicular multispecific organic anion transporter 2 IC50 133000.0 nM 10.1093/toxsci/kft176
Homo sapiens Cannabinoid CB1 receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Cannabinoid CB1 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Cannabinoid CB1 receptor IC50 nan None None
Homo sapiens Cannabinoid CB1 receptor Ki nan None None
Homo sapiens Carbonic anhydrase I IC50 10000.0 nM 10.1021/jm058225d
Homo sapiens Carbonic anhydrase I IC50 50000.0 nM 10.1016/j.bmcl.2003.11.014
Homo sapiens Carbonic anhydrase I IC50 50000.0 nM 10.1021/jm030912m
Homo sapiens Carbonic anhydrase I Ki 10000.0 nM 10.1016/j.bmc.2017.02.037
Homo sapiens Carbonic anhydrase I Ki 50000.0 nM 10.1016/j.bmc.2008.12.035
Homo sapiens Carbonic anhydrase I Ki 50000.0 nM 10.1016/j.bmc.2009.05.002
Homo sapiens Carbonic anhydrase I Ki 50000.0 nM 10.1016/j.bmc.2009.05.063
Homo sapiens Carbonic anhydrase I Ki 50000.0 nM 10.1016/j.bmc.2010.06.056
Homo sapiens Carbonic anhydrase I Ki 50000.0 nM 10.1016/j.bmc.2010.12.048
Homo sapiens Carbonic anhydrase I Ki 50000.0 nM 10.1016/j.bmc.2011.06.038
Homo sapiens Carbonic anhydrase I Ki 50000.0 nM 10.1016/j.bmc.2012.01.007
Homo sapiens Carbonic anhydrase I Ki 50000.0 nM 10.1016/j.bmc.2012.07.024
Homo sapiens Carbonic anhydrase I Ki 50000.0 nM 10.1016/j.bmc.2013.06.035
Homo sapiens Carbonic anhydrase I Ki 50000.0 nM 10.1016/j.bmc.2013.07.044
Homo sapiens Carbonic anhydrase I Ki 50000.0 nM 10.1016/j.bmc.2014.01.031
Homo sapiens Carbonic anhydrase I Ki 50000.0 nM 10.1016/j.bmc.2014.04.006
Homo sapiens Carbonic anhydrase I Ki 50000.0 nM 10.1016/j.bmc.2014.07.048
Homo sapiens Carbonic anhydrase I Ki 50000.0 nM 10.1016/j.bmc.2014.12.009
Homo sapiens Carbonic anhydrase I Ki 50000.0 nM 10.1016/j.bmc.2015.02.027
Homo sapiens Carbonic anhydrase I Ki 50000.0 nM 10.1016/j.bmc.2015.02.045
Homo sapiens Carbonic anhydrase I Ki 50000.0 nM 10.1016/j.bmc.2015.03.081
Homo sapiens Carbonic anhydrase I Ki 50000.0 nM 10.1016/j.bmc.2016.01.037
Homo sapiens Carbonic anhydrase I Ki 50000.0 nM 10.1016/j.bmc.2017.05.007
Homo sapiens Carbonic anhydrase I Ki 50000.0 nM 10.1016/j.bmcl.2004.09.085
Homo sapiens Carbonic anhydrase I Ki 50000.0 nM 10.1016/j.bmcl.2004.12.009
Homo sapiens Carbonic anhydrase I Ki 50000.0 nM 10.1016/j.bmcl.2005.09.040
Homo sapiens Carbonic anhydrase I Ki 50000.0 nM 10.1016/j.bmcl.2010.06.082
Homo sapiens Carbonic anhydrase I Ki 50000.0 nM 10.1016/j.bmcl.2010.11.124
Homo sapiens Carbonic anhydrase I Ki 50000.0 nM 10.1016/j.bmcl.2011.07.090
Homo sapiens Carbonic anhydrase I Ki 50000.0 nM 10.1016/j.bmcl.2015.10.074
Homo sapiens Carbonic anhydrase I Ki 50000.0 nM 10.1016/j.bmcl.2015.11.104
Homo sapiens Carbonic anhydrase I Ki 50000.0 nM 10.1016/j.bmcl.2016.02.032
Homo sapiens Carbonic anhydrase I Ki 50000.0 nM 10.1016/j.bmcl.2016.07.060
Homo sapiens Carbonic anhydrase I Ki 50000.0 nM 10.1016/j.bmcl.2016.12.035
Homo sapiens Carbonic anhydrase I Ki 50000.0 nM 10.1021/jm300878g
Homo sapiens Carbonic anhydrase I Ki 50000.0 nM 10.1021/jm301611m
Homo sapiens Carbonic anhydrase I Ki 50000.0 nM 10.1021/jm4000616
Homo sapiens Carbonic anhydrase I Ki 50000.0 nM 10.1021/jm801267c
Homo sapiens Carbonic anhydrase I Ki 50000.0 nM 10.1021/jm9000488
Homo sapiens Carbonic anhydrase I Ki 50000.0 nM 10.1021/jm9003126
Homo sapiens Carbonic anhydrase II IC50 21.0 nM 10.1016/j.bmcl.2003.11.014
Homo sapiens Carbonic anhydrase II IC50 21.0 nM 10.1021/jm030912m
Homo sapiens Carbonic anhydrase II IC50 21.0 nM 10.1021/jm058225d
Homo sapiens Carbonic anhydrase II IC50 181.0 nM None
Homo sapiens Carbonic anhydrase II Ki 21.0 nM 10.1016/j.bmc.2008.12.035
Homo sapiens Carbonic anhydrase II Ki 21.0 nM 10.1016/j.bmc.2009.05.002
Homo sapiens Carbonic anhydrase II Ki 21.0 nM 10.1016/j.bmc.2009.05.063
Homo sapiens Carbonic anhydrase II Ki 21.0 nM 10.1016/j.bmc.2010.06.056
Homo sapiens Carbonic anhydrase II Ki 21.0 nM 10.1016/j.bmc.2010.12.048
Homo sapiens Carbonic anhydrase II Ki 21.0 nM 10.1016/j.bmc.2011.06.038
Homo sapiens Carbonic anhydrase II Ki 21.0 nM 10.1016/j.bmc.2012.01.007
Homo sapiens Carbonic anhydrase II Ki 21.0 nM 10.1016/j.bmc.2012.07.024
Homo sapiens Carbonic anhydrase II Ki 21.0 nM 10.1016/j.bmc.2013.06.035
Homo sapiens Carbonic anhydrase II Ki 21.0 nM 10.1016/j.bmc.2013.07.044
Homo sapiens Carbonic anhydrase II Ki 21.0 nM 10.1016/j.bmc.2014.01.031
Homo sapiens Carbonic anhydrase II Ki 21.0 nM 10.1016/j.bmc.2014.04.006
Homo sapiens Carbonic anhydrase II Ki 21.0 nM 10.1016/j.bmc.2014.07.048
Homo sapiens Carbonic anhydrase II Ki 21.0 nM 10.1016/j.bmc.2014.12.009
Homo sapiens Carbonic anhydrase II Ki 21.0 nM 10.1016/j.bmc.2015.02.027
Homo sapiens Carbonic anhydrase II Ki 21.0 nM 10.1016/j.bmc.2015.02.045
Homo sapiens Carbonic anhydrase II Ki 21.0 nM 10.1016/j.bmc.2015.03.081
Homo sapiens Carbonic anhydrase II Ki 21.0 nM 10.1016/j.bmc.2016.01.037
Homo sapiens Carbonic anhydrase II Ki 21.0 nM 10.1016/j.bmc.2017.02.037
Homo sapiens Carbonic anhydrase II Ki 21.0 nM 10.1016/j.bmc.2017.05.007
Homo sapiens Carbonic anhydrase II Ki 21.0 nM 10.1016/j.bmcl.2004.12.009
Homo sapiens Carbonic anhydrase II Ki 21.0 nM 10.1016/j.bmcl.2005.09.040
Homo sapiens Carbonic anhydrase II Ki 21.0 nM 10.1016/j.bmcl.2009.10.009
Homo sapiens Carbonic anhydrase II Ki 21.0 nM 10.1016/j.bmcl.2010.06.082
Homo sapiens Carbonic anhydrase II Ki 21.0 nM 10.1016/j.bmcl.2010.11.124
Homo sapiens Carbonic anhydrase II Ki 21.0 nM 10.1016/j.bmcl.2011.07.090
Homo sapiens Carbonic anhydrase II Ki 21.0 nM 10.1016/j.bmcl.2013.11.021
Homo sapiens Carbonic anhydrase II Ki 21.0 nM 10.1016/j.bmcl.2015.06.079
Homo sapiens Carbonic anhydrase II Ki 21.0 nM 10.1016/j.bmcl.2015.10.074
Homo sapiens Carbonic anhydrase II Ki 21.0 nM 10.1016/j.bmcl.2015.11.104
Homo sapiens Carbonic anhydrase II Ki 21.0 nM 10.1016/j.bmcl.2016.01.023
Homo sapiens Carbonic anhydrase II Ki 21.0 nM 10.1016/j.bmcl.2016.02.032
Homo sapiens Carbonic anhydrase II Ki 21.0 nM 10.1016/j.bmcl.2016.07.060
Homo sapiens Carbonic anhydrase II Ki 21.0 nM 10.1016/j.bmcl.2016.12.035
Homo sapiens Carbonic anhydrase II Ki 21.0 nM 10.1016/j.ejmech.2020.112923
Homo sapiens Carbonic anhydrase II Ki 21.0 nM 10.1021/jm050333c
Homo sapiens Carbonic anhydrase II Ki 21.0 nM 10.1021/jm300203r
Homo sapiens Carbonic anhydrase II Ki 21.0 nM 10.1021/jm300878g
Homo sapiens Carbonic anhydrase II Ki 21.0 nM 10.1021/jm301611m
Homo sapiens Carbonic anhydrase II Ki 21.0 nM 10.1021/jm4000616
Homo sapiens Carbonic anhydrase II Ki 21.0 nM 10.1021/jm801267c
Homo sapiens Carbonic anhydrase II Ki 21.0 nM 10.1021/jm9000488
Homo sapiens Carbonic anhydrase II Ki 21.0 nM 10.1021/jm9003126
Homo sapiens Carbonic anhydrase II Ki 76.8 nM 10.1016/j.bmc.2012.02.029
Homo sapiens Carbonic anhydrase II Ki 421.0 nM 10.1016/j.bmc.2012.02.029
Homo sapiens Carbonic anhydrase II Ki 21000.0 nM 10.1016/j.bmcl.2004.09.085
Homo sapiens Carbonic anhydrase II Ki nan None None
Homo sapiens Carbonic anhydrase III Ki 7400.0 nM 10.1021/jm300878g
Homo sapiens Carbonic anhydrase III Ki 70000.0 nM 10.1016/j.bmcl.2010.06.082
Homo sapiens Carbonic anhydrase III Ki 154000.0 nM 10.1016/j.bmc.2007.08.037
Homo sapiens Carbonic anhydrase IV Ki 290.0 nM 10.1016/j.bmc.2017.02.037
Homo sapiens Carbonic anhydrase IV Ki 290.0 nM 10.1016/j.ejmech.2020.112923
Homo sapiens Carbonic anhydrase IV Ki 880.0 nM 10.1016/j.bmcl.2004.12.009
Homo sapiens Carbonic anhydrase IV Ki 880.0 nM 10.1016/j.bmcl.2010.06.082
Homo sapiens Carbonic anhydrase IV Ki 880.0 nM 10.1021/jm300878g
Homo sapiens Carbonic anhydrase IX IC50 16.0 nM 10.1021/jm030912m
Homo sapiens Carbonic anhydrase IX IC50 16.0 nM 10.1021/jm058225d
Homo sapiens Carbonic anhydrase IX Ki 14.8 nM 10.1016/j.ejmech.2020.112923
Homo sapiens Carbonic anhydrase IX Ki 16.0 nM 10.1016/j.bmc.2013.07.044
Homo sapiens Carbonic anhydrase IX Ki 16.0 nM 10.1016/j.bmc.2014.01.031
Homo sapiens Carbonic anhydrase IX Ki 16.0 nM 10.1016/j.bmc.2015.02.027
Homo sapiens Carbonic anhydrase IX Ki 16.0 nM 10.1016/j.bmcl.2005.09.040
Homo sapiens Carbonic anhydrase IX Ki 16.0 nM 10.1016/j.bmcl.2010.06.082
Homo sapiens Carbonic anhydrase IX Ki 16.0 nM 10.1016/j.bmcl.2011.07.090
Homo sapiens Carbonic anhydrase IX Ki 16.0 nM 10.1016/j.ejmech.2020.112666
Homo sapiens Carbonic anhydrase IX Ki 16.0 nM 10.1021/jm050333c
Homo sapiens Carbonic anhydrase IX Ki 16.0 nM 10.1021/jm300878g
Homo sapiens Carbonic anhydrase IX Ki 16.0 nM 10.1021/jm801267c
Homo sapiens Carbonic anhydrase IX Ki 20.0 nM 10.1016/j.bmc.2017.02.037
Homo sapiens Carbonic anhydrase IX Ki 16000.0 nM 10.1016/j.bmcl.2004.09.085
Homo sapiens Carbonic anhydrase VA Ki 794.0 nM 10.1016/j.bmcl.2010.06.082
Homo sapiens Carbonic anhydrase VA Ki 794.0 nM 10.1021/jm300878g
Homo sapiens Carbonic anhydrase VB Ki 93.0 nM 10.1016/j.bmcl.2010.06.082
Homo sapiens Carbonic anhydrase VB Ki 93.0 nM 10.1021/jm300878g
Homo sapiens Carbonic anhydrase VI Ki 94.0 nM 10.1016/j.bmcl.2010.06.082
Homo sapiens Carbonic anhydrase VI Ki 94.0 nM 10.1021/jm300878g
Homo sapiens Carbonic anhydrase VI Ki 94.0 nM 10.1021/jm801267c
Homo sapiens Carbonic anhydrase VI Ki nan None 10.1016/j.bmcl.2010.11.124
Homo sapiens Carbonic anhydrase VII Ki 2170.0 nM 10.1016/j.bmc.2013.06.035
Homo sapiens Carbonic anhydrase VII Ki 2170.0 nM 10.1016/j.bmc.2013.07.044
Homo sapiens Carbonic anhydrase VII Ki 2170.0 nM 10.1016/j.bmc.2015.02.027
Homo sapiens Carbonic anhydrase VII Ki 2170.0 nM 10.1016/j.bmcl.2010.06.082
Homo sapiens Carbonic anhydrase VII Ki 2170.0 nM 10.1016/j.ejmech.2013.10.071
Homo sapiens Carbonic anhydrase VII Ki 2170.0 nM 10.1021/jm300878g
Homo sapiens Carbonic anhydrase XII Ki 18.0 nM 10.1016/j.bmc.2013.07.044
Homo sapiens Carbonic anhydrase XII Ki 18.0 nM 10.1016/j.bmc.2014.01.031
Homo sapiens Carbonic anhydrase XII Ki 18.0 nM 10.1016/j.bmc.2015.02.027
Homo sapiens Carbonic anhydrase XII Ki 18.0 nM 10.1016/j.bmcl.2005.09.040
Homo sapiens Carbonic anhydrase XII Ki 18.0 nM 10.1016/j.bmcl.2010.06.082
Homo sapiens Carbonic anhydrase XII Ki 18.0 nM 10.1016/j.bmcl.2011.07.090
Homo sapiens Carbonic anhydrase XII Ki 18.0 nM 10.1021/jm300878g
Homo sapiens Carbonic anhydrase XIII Ki 98.0 nM 10.1016/j.bmcl.2010.06.082
Homo sapiens Carbonic anhydrase XIII Ki 98.0 nM 10.1021/jm300878g
Homo sapiens Carbonic anhydrase XIV Ki 689.0 nM 10.1016/j.bmcl.2010.06.082
Homo sapiens Carbonic anhydrase XIV Ki 689.0 nM 10.1021/jm300878g
Homo sapiens Caspase-1 IC50 nan None None
Homo sapiens Caspase-1 Ki nan None None
Homo sapiens Cathepsin G IC50 nan None None
Homo sapiens Cathepsin G Ki nan None None
Homo sapiens C-C chemokine receptor type 2 IC50 nan None None
Homo sapiens C-C chemokine receptor type 2 Ki nan None None
Homo sapiens C-C chemokine receptor type 4 IC50 nan None None
Homo sapiens C-C chemokine receptor type 4 Ki nan None None
Homo sapiens C-C chemokine receptor type 5 IC50 nan None None
Homo sapiens C-C chemokine receptor type 5 Ki nan None None
Homo sapiens CCRF-CEM GI50 13963.68 nM None
Homo sapiens Cholecystokinin A receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Cholecystokinin A receptor IC50 nan None None
Homo sapiens Cholecystokinin A receptor Ki nan None None
Homo sapiens Cholecystokinin B receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens COLO 205 GI50 16069.41 nM None
Homo sapiens Corticotropin releasing factor receptor 1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Corticotropin releasing factor receptor 2 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens COX-1/COX-2 Ratio IC50 3.66 None 10.1016/j.ejmech.2021.113804
Homo sapiens COX-1/COX-2 Ratio IC50 7.46 None 10.1016/j.ejmech.2013.12.033
Homo sapiens COX-1/COX-2 Ratio IC50 14.2 None 10.1039/d1md00280e
Homo sapiens COX-1/COX-2 Ratio IC50 23.0 None 10.1016/j.bmc.2013.12.008
Homo sapiens COX-1/COX-2 Ratio IC50 37.0 None 10.1016/j.bmc.2011.04.050
Homo sapiens COX-1/COX-2 Ratio IC50 40.0 None 10.1016/j.ejmech.2022.114597
Homo sapiens COX-1/COX-2 Ratio IC50 75.56 None 10.1016/j.ejmech.2014.05.012
Homo sapiens COX-1/COX-2 Ratio IC50 82.83 None 10.1016/j.bmcl.2020.127743
Homo sapiens COX-1/COX-2 Ratio IC50 178.6 None 10.1016/j.ejmech.2021.114085
Homo sapiens COX-1/COX-2 Ratio IC50 333.33 None 10.1016/j.ejmech.2017.09.056
Homo sapiens Cyclooxygenase IC50 89.0 nM 10.1016/j.ejmech.2017.09.056
Homo sapiens Cyclooxygenase Ratio 7.3 None 10.1021/jm010458r
Homo sapiens Cyclooxygenase Ratio 13.0 None 10.1021/jm991106b
Homo sapiens Cyclooxygenase Ratio 117.0 None 10.1021/jm010484p
Homo sapiens Cyclooxygenase Ratio 2400.0 None 10.1021/jm9906015
Homo sapiens Cyclooxygenase Selectivity 11.0 None 10.1021/jm030268b
Homo sapiens Cyclooxygenase Selectivity 11.0 None 10.1021/jm0582064
Homo sapiens Cyclooxygenase Selectivity 18.4 None 10.1016/s0960-894x(00)00329-2
Homo sapiens Cyclooxygenase Selectivity 24.8 None 10.1016/j.bmcl.2004.07.089
Homo sapiens Cyclooxygenase Selectivity 403.0 None 10.1016/j.bmcl.2004.01.075
Homo sapiens Cyclooxygenase Selectivity nan None 10.1021/jm030268b
Homo sapiens Cyclooxygenase Selectivity index 1.68 None 10.1016/j.bmcl.2006.06.032
Homo sapiens Cyclooxygenase Selectivity index 60.25 None 10.1016/j.bmcl.2006.06.036
Homo sapiens Cyclooxygenase Selectivity index 219.0 None 10.1021/jm020563g
Homo sapiens Cyclooxygenase Selectivity index 404.0 None 10.1016/s0960-894x(02)00537-1
Homo sapiens Cyclooxygenase Selectivity index 404.0 None 10.1021/jm0101287
Homo sapiens Cyclooxygenase-1 Delta G 0.0 kCal mol-1 10.1016/s0960-894x(00)00522-9
Homo sapiens Cyclooxygenase-1 IC50 13.0 nM 10.1016/j.bmcl.2022.129101
Homo sapiens Cyclooxygenase-1 IC50 50.0 nM 10.1016/s0960-894x(03)00046-5
Homo sapiens Cyclooxygenase-1 IC50 50.0 nM 10.1016/s0960-894x(99)00559-4
Homo sapiens Cyclooxygenase-1 IC50 50.0 nM 10.1016/s0960-894x(99)00560-0
Homo sapiens Cyclooxygenase-1 IC50 50.0 nM 10.1021/jm980642l
Homo sapiens Cyclooxygenase-1 IC50 125.0 nM 10.1016/j.bmcl.2017.04.020
Homo sapiens Cyclooxygenase-1 IC50 131.97 nM 10.1016/j.ejmech.2019.03.052
Homo sapiens Cyclooxygenase-1 IC50 300.0 nM 10.1016/j.ejmech.2019.03.036
Homo sapiens Cyclooxygenase-1 IC50 410.0 nM 10.1021/acs.jmedchem.1c00890
Homo sapiens Cyclooxygenase-1 IC50 723.0 nM None
Homo sapiens Cyclooxygenase-1 IC50 1000.0 nM 10.1016/j.bmcl.2009.02.085
Homo sapiens Cyclooxygenase-1 IC50 1689.0 nM 10.1016/j.bmcl.2004.07.089
Homo sapiens Cyclooxygenase-1 IC50 1689.0 nM 10.1016/j.bmcl.2009.02.085
Homo sapiens Cyclooxygenase-1 IC50 1880.0 nM 10.1016/s0960-894x(01)00800-9
Homo sapiens Cyclooxygenase-1 IC50 2000.0 nM 10.1021/jm010458r
Homo sapiens Cyclooxygenase-1 IC50 2600.0 nM 10.1016/j.ejmech.2013.12.033
Homo sapiens Cyclooxygenase-1 IC50 2600.0 nM 10.1021/jm049480l
Homo sapiens Cyclooxygenase-1 IC50 2600.0 nM 10.1021/jm900702b
Homo sapiens Cyclooxygenase-1 IC50 5100.0 nM 10.1021/jm0009383
Homo sapiens Cyclooxygenase-1 IC50 5100.0 nM 10.1021/jm030765s
Homo sapiens Cyclooxygenase-1 IC50 5330.0 nM 10.1016/j.bmcl.2020.127376
Homo sapiens Cyclooxygenase-1 IC50 6120.0 nM 10.1016/j.ejmech.2020.112662
Homo sapiens Cyclooxygenase-1 IC50 6130.0 nM 10.1016/j.bmcl.2019.05.051
Homo sapiens Cyclooxygenase-1 IC50 6300.0 nM 10.1016/s0960-894x(03)00046-5
Homo sapiens Cyclooxygenase-1 IC50 6300.0 nM 10.1016/s0960-894x(99)00288-7
Homo sapiens Cyclooxygenase-1 IC50 6300.0 nM 10.1016/s0960-894x(99)00365-0
Homo sapiens Cyclooxygenase-1 IC50 6300.0 nM 10.1016/s0960-894x(99)00559-4
Homo sapiens Cyclooxygenase-1 IC50 6300.0 nM 10.1021/jm980642l
Homo sapiens Cyclooxygenase-1 IC50 6650.0 nM 10.1016/j.bmc.2013.01.058
Homo sapiens Cyclooxygenase-1 IC50 7000.0 nM 10.1016/j.bmc.2011.04.050
Homo sapiens Cyclooxygenase-1 IC50 7700.0 nM 10.1016/j.bmc.2008.12.032
Homo sapiens Cyclooxygenase-1 IC50 8000.0 nM 10.1021/acs.jmedchem.1c01571
Homo sapiens Cyclooxygenase-1 IC50 8750.0 nM 10.1039/C9MD00228F
Homo sapiens Cyclooxygenase-1 IC50 9200.0 nM 10.1021/acs.jmedchem.1c00890
Homo sapiens Cyclooxygenase-1 IC50 9730.0 nM 10.1016/s0960-894x(00)00329-2
Homo sapiens Cyclooxygenase-1 IC50 10000.0 nM 10.1016/j.bmc.2012.09.021
Homo sapiens Cyclooxygenase-1 IC50 10000.0 nM 10.1021/acs.jmedchem.6b01484
Homo sapiens Cyclooxygenase-1 IC50 10194.0 nM 10.1016/j.bmcl.2009.02.085
Homo sapiens Cyclooxygenase-1 IC50 10700.0 nM 10.1016/s0960-894x(03)00282-8
Homo sapiens Cyclooxygenase-1 IC50 12470.0 nM 10.1016/j.bmc.2013.12.008
Homo sapiens Cyclooxygenase-1 IC50 12470.0 nM 10.1021/jm200715n
Homo sapiens Cyclooxygenase-1 IC50 12500.0 nM 10.1021/jm0707525
Homo sapiens Cyclooxygenase-1 IC50 12500.0 nM 10.1021/jm901269y
Homo sapiens Cyclooxygenase-1 IC50 13100.0 nM 10.1016/j.bmc.2010.04.034
Homo sapiens Cyclooxygenase-1 IC50 13500.0 nM 10.1021/jm0407761
Homo sapiens Cyclooxygenase-1 IC50 14000.0 nM 10.1016/j.bmcl.2004.09.073
Homo sapiens Cyclooxygenase-1 IC50 14000.0 nM 10.1016/j.ejmech.2007.12.017
Homo sapiens Cyclooxygenase-1 IC50 14000.0 nM 10.1021/jm030268b
Homo sapiens Cyclooxygenase-1 IC50 14000.0 nM 10.1021/jm030276s
Homo sapiens Cyclooxygenase-1 IC50 14000.0 nM 10.1021/jm0582064
Homo sapiens Cyclooxygenase-1 IC50 14000.0 nM 10.1021/jm0607247
Homo sapiens Cyclooxygenase-1 IC50 14000.0 nM 10.1021/jm0611861
Homo sapiens Cyclooxygenase-1 IC50 14200.0 nM 10.1021/jm991106b
Homo sapiens Cyclooxygenase-1 IC50 14800.0 nM 10.1021/acs.jmedchem.1c00890
Homo sapiens Cyclooxygenase-1 IC50 15000.0 nM 10.1016/j.bmcl.2010.12.023
Homo sapiens Cyclooxygenase-1 IC50 15000.0 nM 10.1016/j.ejmech.2014.01.030
Homo sapiens Cyclooxygenase-1 IC50 15000.0 nM 10.1016/s0960-894x(99)00157-2
Homo sapiens Cyclooxygenase-1 IC50 15000.0 nM 10.1021/jm201528b
Homo sapiens Cyclooxygenase-1 IC50 15000.0 nM 10.1021/jm960803q
Homo sapiens Cyclooxygenase-1 IC50 15000.0 nM 10.1021/jm990577v
Homo sapiens Cyclooxygenase-1 IC50 15030.0 nM 10.1016/j.bmc.2014.05.059
Homo sapiens Cyclooxygenase-1 IC50 15275.0 nM 10.1016/j.ejmech.2022.114597
Homo sapiens Cyclooxygenase-1 IC50 16000.0 nM 10.1016/j.bmc.2008.07.058
Homo sapiens Cyclooxygenase-1 IC50 19880.0 nM 10.1016/j.bmcl.2020.127743
Homo sapiens Cyclooxygenase-1 IC50 20030.0 nM 10.1016/j.bmcl.2006.06.036
Homo sapiens Cyclooxygenase-1 IC50 20400.0 nM 10.1016/j.ejmech.2014.05.012
Homo sapiens Cyclooxygenase-1 IC50 22900.0 nM 10.1016/s0960-894x(02)00537-1
Homo sapiens Cyclooxygenase-1 IC50 22900.0 nM 10.1021/jm0101287
Homo sapiens Cyclooxygenase-1 IC50 22900.0 nM 10.1021/jm010153c
Homo sapiens Cyclooxygenase-1 IC50 23000.0 nM None
Homo sapiens Cyclooxygenase-1 IC50 23470.0 nM 10.1016/j.bmc.2007.11.033
Homo sapiens Cyclooxygenase-1 IC50 24300.0 nM 10.1016/j.bmcl.2007.07.084
Homo sapiens Cyclooxygenase-1 IC50 24470.0 nM 10.1016/j.ejmech.2019.03.008
Homo sapiens Cyclooxygenase-1 IC50 25390.0 nM 10.1016/j.bmcl.2016.12.069
Homo sapiens Cyclooxygenase-1 IC50 25740.0 nM 10.1016/j.ejmech.2013.10.032
Homo sapiens Cyclooxygenase-1 IC50 26400.0 nM 10.1021/jm010458r
Homo sapiens Cyclooxygenase-1 IC50 27000.0 nM 10.1021/jm010484p
Homo sapiens Cyclooxygenase-1 IC50 27500.0 nM 10.1016/j.bmc.2011.09.034
Homo sapiens Cyclooxygenase-1 IC50 27500.0 nM 10.1016/j.ejmech.2012.11.021
Homo sapiens Cyclooxygenase-1 IC50 27830.0 nM 10.1016/j.ejmech.2019.111780
Homo sapiens Cyclooxygenase-1 IC50 32600.0 nM 10.1016/j.bmcl.2015.03.022
Homo sapiens Cyclooxygenase-1 IC50 36440.0 nM 10.1016/j.bmcl.2017.07.020
Homo sapiens Cyclooxygenase-1 IC50 37310.0 nM 10.1016/j.ejmech.2020.112066
Homo sapiens Cyclooxygenase-1 IC50 43370.0 nM 10.1016/j.bmcl.2016.06.037
Homo sapiens Cyclooxygenase-1 IC50 46890.0 nM 10.1016/j.bmc.2018.07.022
Homo sapiens Cyclooxygenase-1 IC50 50000.0 nM 10.1016/j.ejmech.2021.114085
Homo sapiens Cyclooxygenase-1 IC50 80900.0 nM 10.1021/acsmedchemlett.1c00065
Homo sapiens Cyclooxygenase-1 IC50 100000.0 nM 10.1016/j.ejmech.2007.03.030
Homo sapiens Cyclooxygenase-1 IC50 100000.0 nM 10.1016/j.ejmech.2010.10.001
Homo sapiens Cyclooxygenase-1 IC50 100000.0 nM 10.1016/j.ejmech.2017.09.056
Homo sapiens Cyclooxygenase-1 IC50 100000.0 nM 10.1021/jm030268b
Homo sapiens Cyclooxygenase-1 IC50 100000.0 nM 10.1021/np0502342
Homo sapiens Cyclooxygenase-1 IC50 12530000.0 nM 10.1016/j.bmc.2013.04.031
Homo sapiens Cyclooxygenase-1 Inhibition 10.75 % 10.1016/j.bmcl.2006.05.028
Homo sapiens Cyclooxygenase-1 Inhibition 13.01 % 10.1016/j.bmcl.2011.01.116
Homo sapiens Cyclooxygenase-1 Inhibition 15.0 uM 10.1016/s0960-894x(98)00627-1
Homo sapiens Cyclooxygenase-1 Inhibition 18.39 % 10.1016/j.ejmech.2007.02.008
Homo sapiens Cyclooxygenase-1 Inhibition 27.9 % 10.1016/j.bmcl.2014.02.073
Homo sapiens Cyclooxygenase-1 Inhibition 34.5 % 10.1021/jm0009383
Homo sapiens Cyclooxygenase-1 Inhibition 50.0 % 10.1016/j.ejmech.2007.08.005
Homo sapiens Cyclooxygenase-1 Inhibition 53.4 % 10.1016/j.bmc.2008.11.018
Homo sapiens Cyclooxygenase-1 Inhibition 62.0 % 10.1016/j.bmcl.2005.05.093
Homo sapiens Cyclooxygenase-1 Inhibition 65.0 % 10.1016/j.bmcl.2004.09.073
Homo sapiens Cyclooxygenase-1 Inhibition 65.0 % 10.1016/j.ejmech.2007.12.017
Homo sapiens Cyclooxygenase-1 Inhibition 80.0 % 10.1021/jm030268b
Homo sapiens Cyclooxygenase-1 Inhibition 80.0 % 10.1021/jm030276s
Homo sapiens Cyclooxygenase-1 Inhibition 96.0 % 10.1016/j.bmc.2008.05.028
Homo sapiens Cyclooxygenase-1 Inhibition 96.0 % 10.1021/jm0705096
Homo sapiens Cyclooxygenase-1 Inhibition nan % 10.1016/j.ejmech.2021.113566
Homo sapiens Cyclooxygenase-1 Inhibition nan % 10.1021/jm030276s
Homo sapiens Cyclooxygenase-1 Ki nan None None
Homo sapiens Cyclooxygenase-1 NT nan None 10.1021/jm030268b
Homo sapiens Cyclooxygenase-1 Ratio 297.22 None 10.1016/s0960-894x(03)00282-8
Homo sapiens Cyclooxygenase-2 AC50 48.4 nM 10.1038/s41467-023-40064-9
Homo sapiens Cyclooxygenase-2 Activity 0.8 % 10.1016/j.bmc.2013.10.006
Homo sapiens Cyclooxygenase-2 Activity 4.6 % 10.1016/j.bmc.2013.10.006
Homo sapiens Cyclooxygenase-2 Activity 6.5 % 10.1021/jm201687d
Homo sapiens Cyclooxygenase-2 Activity 7.3 % 10.1021/jm201687d
Homo sapiens Cyclooxygenase-2 Activity 21.0 % 10.1021/jm801085s
Homo sapiens Cyclooxygenase-2 Activity 22.0 % 10.1016/j.ejmech.2014.05.033
Homo sapiens Cyclooxygenase-2 Activity 22.4 % 10.1021/np500198g
Homo sapiens Cyclooxygenase-2 Activity 60.0 % 10.1016/j.bmc.2022.117085
Homo sapiens Cyclooxygenase-2 Delta G 0.0 kCal mol-1 10.1016/s0960-894x(00)00522-9
Homo sapiens Cyclooxygenase-2 FC 5.0 None 10.1021/acs.jnatprod.0c00300
Homo sapiens Cyclooxygenase-2 IC50 0.52 nM 10.1016/j.ejmech.2007.06.022
Homo sapiens Cyclooxygenase-2 IC50 2.0 nM 10.1016/s0960-894x(03)00046-5
Homo sapiens Cyclooxygenase-2 IC50 2.0 nM 10.1016/s0960-894x(99)00559-4
Homo sapiens Cyclooxygenase-2 IC50 2.0 nM 10.1016/s0960-894x(99)00560-0
Homo sapiens Cyclooxygenase-2 IC50 2.0 nM 10.1021/jm980642l
Homo sapiens Cyclooxygenase-2 IC50 2.2 nM 10.1016/j.bmcl.2006.06.032
Homo sapiens Cyclooxygenase-2 IC50 4.8 nM 10.1016/j.bmcl.2017.04.020
Homo sapiens Cyclooxygenase-2 IC50 6.0 nM 10.1016/j.ejmech.2021.113682
Homo sapiens Cyclooxygenase-2 IC50 6.0 nM 10.1021/jm050619h
Homo sapiens Cyclooxygenase-2 IC50 6.8 nM 10.1021/jm050619h
Homo sapiens Cyclooxygenase-2 IC50 7.0 nM 10.1021/acs.jmedchem.6b01484
Homo sapiens Cyclooxygenase-2 IC50 10.0 nM 10.1021/jm2001376
Homo sapiens Cyclooxygenase-2 IC50 10.25 nM 10.1039/d1md00280e
Homo sapiens Cyclooxygenase-2 IC50 11.2 nM 10.1016/j.ejmech.2019.07.004
Homo sapiens Cyclooxygenase-2 IC50 12.0 nM 10.1016/j.bmc.2017.11.027
Homo sapiens Cyclooxygenase-2 IC50 12.2 nM 10.1016/j.ejmech.2022.114597
Homo sapiens Cyclooxygenase-2 IC50 16.0 nM 10.1016/j.bmcl.2015.04.085
Homo sapiens Cyclooxygenase-2 IC50 17.79 nM 10.1016/j.ejmech.2019.03.036
Homo sapiens Cyclooxygenase-2 IC50 19.0 nM 10.1016/j.bmcl.2015.03.017
Homo sapiens Cyclooxygenase-2 IC50 19.0 nM 10.1016/j.bmcl.2015.08.034
Homo sapiens Cyclooxygenase-2 IC50 20.0 nM 10.1016/j.bmc.2013.04.074
Homo sapiens Cyclooxygenase-2 IC50 20.0 nM 10.1016/j.bmcl.2016.08.034
Homo sapiens Cyclooxygenase-2 IC50 28.0 nM 10.1021/acs.jmedchem.1c00890
Homo sapiens Cyclooxygenase-2 IC50 30.0 nM 10.1016/j.bmcl.2011.01.057
Homo sapiens Cyclooxygenase-2 IC50 30.0 nM 10.1016/j.bmcl.2012.03.013
Homo sapiens Cyclooxygenase-2 IC50 30.0 nM 10.1016/j.bmcl.2017.02.076
Homo sapiens Cyclooxygenase-2 IC50 35.0 nM 10.1016/j.bmc.2007.06.030
Homo sapiens Cyclooxygenase-2 IC50 35.56 nM 10.1016/j.ejmech.2019.03.052
Homo sapiens Cyclooxygenase-2 IC50 36.0 nM 10.1016/j.bmcl.2003.10.027
Homo sapiens Cyclooxygenase-2 IC50 36.0 nM 10.1016/j.bmcl.2004.01.053
Homo sapiens Cyclooxygenase-2 IC50 36.0 nM 10.1016/s0960-894x(03)00282-8
Homo sapiens Cyclooxygenase-2 IC50 36.0 nM 10.1021/jm0407761
Homo sapiens Cyclooxygenase-2 IC50 39.81 nM 10.1021/jm0101343
Homo sapiens Cyclooxygenase-2 IC50 40.0 nM 10.1016/j.bmc.2012.02.021
Homo sapiens Cyclooxygenase-2 IC50 40.0 nM 10.1016/j.bmc.2014.05.059
Homo sapiens Cyclooxygenase-2 IC50 40.0 nM 10.1016/j.bmc.2019.115246
Homo sapiens Cyclooxygenase-2 IC50 40.0 nM 10.1016/j.bmcl.2010.12.023
Homo sapiens Cyclooxygenase-2 IC50 40.0 nM 10.1016/j.bmcl.2013.11.080
Homo sapiens Cyclooxygenase-2 IC50 40.0 nM 10.1016/j.bmcl.2014.03.087
Homo sapiens Cyclooxygenase-2 IC50 40.0 nM 10.1016/j.bmcl.2016.02.029
Homo sapiens Cyclooxygenase-2 IC50 40.0 nM 10.1016/j.ejmech.2014.01.030
Homo sapiens Cyclooxygenase-2 IC50 40.0 nM 10.1016/j.ejmech.2014.03.003
Homo sapiens Cyclooxygenase-2 IC50 40.0 nM 10.1016/j.ejmech.2015.04.044
Homo sapiens Cyclooxygenase-2 IC50 40.0 nM 10.1016/j.ejmech.2018.10.054
Homo sapiens Cyclooxygenase-2 IC50 40.0 nM 10.1016/s0960-894x(01)00825-3
Homo sapiens Cyclooxygenase-2 IC50 40.0 nM 10.1016/s0960-894x(99)00157-2
Homo sapiens Cyclooxygenase-2 IC50 40.0 nM 10.1021/acs.jmedchem.1c00880
Homo sapiens Cyclooxygenase-2 IC50 40.0 nM 10.1021/acs.jmedchem.1c01571
Homo sapiens Cyclooxygenase-2 IC50 40.0 nM 10.1021/acs.jmedchem.6b00134
Homo sapiens Cyclooxygenase-2 IC50 40.0 nM 10.1021/acs.jmedchem.8b00922
Homo sapiens Cyclooxygenase-2 IC50 40.0 nM 10.1021/acs.jmedchem.9b00823
Homo sapiens Cyclooxygenase-2 IC50 40.0 nM 10.1021/jm201528b
Homo sapiens Cyclooxygenase-2 IC50 40.0 nM 10.1021/jm960803q
Homo sapiens Cyclooxygenase-2 IC50 40.0 nM 10.1021/jm990577v
Homo sapiens Cyclooxygenase-2 IC50 40.0 nM 10.1039/C5MD00278H
Homo sapiens Cyclooxygenase-2 IC50 42.0 nM 10.1016/j.bmcl.2012.08.082
Homo sapiens Cyclooxygenase-2 IC50 45.0 nM 10.1016/j.bmc.2020.115403
Homo sapiens Cyclooxygenase-2 IC50 45.0 nM 10.1016/j.ejmech.2021.113457
Homo sapiens Cyclooxygenase-2 IC50 48.0 nM 10.1016/j.ejmech.2020.112438
Homo sapiens Cyclooxygenase-2 IC50 49.0 nM 10.1016/j.ejmech.2019.111693
Homo sapiens Cyclooxygenase-2 IC50 49.0 nM 10.1039/d1md00280e
Homo sapiens Cyclooxygenase-2 IC50 50.0 nM 10.1016/j.bmc.2017.08.039
Homo sapiens Cyclooxygenase-2 IC50 50.0 nM 10.1016/j.ejmech.2017.12.065
Homo sapiens Cyclooxygenase-2 IC50 50.0 nM 10.1016/j.ejmech.2019.02.034
Homo sapiens Cyclooxygenase-2 IC50 50.0 nM 10.1016/j.ejmech.2020.112439
Homo sapiens Cyclooxygenase-2 IC50 50.0 nM 10.1021/ml500156v
Homo sapiens Cyclooxygenase-2 IC50 50.7 nM 10.1021/jm010153c
Homo sapiens Cyclooxygenase-2 IC50 52.0 nM 10.1016/j.bmcl.2015.03.022
Homo sapiens Cyclooxygenase-2 IC50 54.0 nM 10.1021/jm030268b
Homo sapiens Cyclooxygenase-2 IC50 54.0 nM 10.1021/jm201528b
Homo sapiens Cyclooxygenase-2 IC50 55.0 nM 10.1039/d1md00280e
Homo sapiens Cyclooxygenase-2 IC50 56.0 nM 10.1016/j.bmc.2021.116344
Homo sapiens Cyclooxygenase-2 IC50 56.7 nM 10.1016/s0960-894x(02)00537-1
Homo sapiens Cyclooxygenase-2 IC50 56.7 nM 10.1021/jm0101287
Homo sapiens Cyclooxygenase-2 IC50 57.0 nM 10.1007/s00044-012-0174-z
Homo sapiens Cyclooxygenase-2 IC50 57.0 nM 10.1016/j.bmcl.2013.11.015
Homo sapiens Cyclooxygenase-2 IC50 57.0 nM 10.1021/acs.jmedchem.1c00890
Homo sapiens Cyclooxygenase-2 IC50 60.0 nM 10.1016/j.bmc.2012.04.022
Homo sapiens Cyclooxygenase-2 IC50 60.0 nM 10.1016/j.bmcl.2007.07.084
Homo sapiens Cyclooxygenase-2 IC50 60.0 nM 10.1016/j.bmcl.2012.01.093
Homo sapiens Cyclooxygenase-2 IC50 60.0 nM 10.1039/C6MD00569A
Homo sapiens Cyclooxygenase-2 IC50 63.0 nM 10.1016/j.bmcl.2009.02.085
Homo sapiens Cyclooxygenase-2 IC50 65.0 nM 10.1016/j.bmcl.2010.06.022
Homo sapiens Cyclooxygenase-2 IC50 65.0 nM 10.1016/j.bmcl.2010.06.155
Homo sapiens Cyclooxygenase-2 IC50 68.0 nM 10.1016/j.bmcl.2004.07.089
Homo sapiens Cyclooxygenase-2 IC50 68.0 nM 10.1016/j.bmcl.2009.02.085
Homo sapiens Cyclooxygenase-2 IC50 70.0 nM 10.1016/j.bmc.2008.12.032
Homo sapiens Cyclooxygenase-2 IC50 70.0 nM 10.1016/j.bmc.2014.02.032
Homo sapiens Cyclooxygenase-2 IC50 70.0 nM 10.1016/j.bmcl.2011.05.017
Homo sapiens Cyclooxygenase-2 IC50 70.0 nM 10.1016/j.bmcl.2012.01.130
Homo sapiens Cyclooxygenase-2 IC50 70.0 nM 10.1016/j.bmcl.2012.10.131
Homo sapiens Cyclooxygenase-2 IC50 70.0 nM 10.1016/j.ejmech.2020.112438
Homo sapiens Cyclooxygenase-2 IC50 70.0 nM 10.1021/acs.jmedchem.9b01183
Homo sapiens Cyclooxygenase-2 IC50 70.0 nM 10.1021/jm020563g
Homo sapiens Cyclooxygenase-2 IC50 70.0 nM 10.1039/C6MD00569A
Homo sapiens Cyclooxygenase-2 IC50 72.0 nM 10.1016/j.bmcl.2014.02.074
Homo sapiens Cyclooxygenase-2 IC50 79.0 nM 10.1021/jm030765s
Homo sapiens Cyclooxygenase-2 IC50 80.0 nM 10.1021/jm0009383
Homo sapiens Cyclooxygenase-2 IC50 80.0 nM 10.1021/np0502342
Homo sapiens Cyclooxygenase-2 IC50 90.0 nM 10.1021/acs.jmedchem.9b01183
Homo sapiens Cyclooxygenase-2 IC50 90.0 nM 10.1021/acsmedchemlett.1c00065
Homo sapiens Cyclooxygenase-2 IC50 100.0 nM 10.1016/j.bmc.2012.09.021
Homo sapiens Cyclooxygenase-2 IC50 100.0 nM 10.1016/j.ejmech.2011.10.029
Homo sapiens Cyclooxygenase-2 IC50 100.0 nM 10.1016/j.ejmech.2012.11.021
Homo sapiens Cyclooxygenase-2 IC50 110.0 nM 10.1016/s0960-894x(01)00800-9
Homo sapiens Cyclooxygenase-2 IC50 110.0 nM 10.1039/d1md00280e
Homo sapiens Cyclooxygenase-2 IC50 115.0 nM 10.1039/d1md00280e
Homo sapiens Cyclooxygenase-2 IC50 120.0 nM 10.1016/j.bmc.2009.05.046
Homo sapiens Cyclooxygenase-2 IC50 120.0 nM 10.1016/j.bmc.2011.09.034
Homo sapiens Cyclooxygenase-2 IC50 120.0 nM 10.1016/j.bmcl.2008.12.066
Homo sapiens Cyclooxygenase-2 IC50 120.0 nM 10.1016/j.bmcl.2010.01.014
Homo sapiens Cyclooxygenase-2 IC50 120.0 nM 10.1021/jm010458r
Homo sapiens Cyclooxygenase-2 IC50 120.0 nM 10.1021/jm8015188
Homo sapiens Cyclooxygenase-2 IC50 120.0 nM 10.1039/d1md00280e
Homo sapiens Cyclooxygenase-2 IC50 130.0 nM 10.1016/j.bmcl.2015.05.059
Homo sapiens Cyclooxygenase-2 IC50 132.0 nM 10.1016/j.ejmech.2020.112918
Homo sapiens Cyclooxygenase-2 IC50 140.0 nM 10.1016/j.bmcl.2012.06.012
Homo sapiens Cyclooxygenase-2 IC50 150.0 nM 10.1016/j.bmc.2018.01.007
Homo sapiens Cyclooxygenase-2 IC50 150.0 nM 10.1016/j.bmcl.2011.01.116
Homo sapiens Cyclooxygenase-2 IC50 160.0 nM 10.1016/j.ejmech.2021.113564
Homo sapiens Cyclooxygenase-2 IC50 190.0 nM 10.1016/j.bmc.2011.04.050
Homo sapiens Cyclooxygenase-2 IC50 200.0 nM 10.1016/j.bmcl.2011.12.072
Homo sapiens Cyclooxygenase-2 IC50 220.0 nM 10.1016/j.bmcl.2019.05.051
Homo sapiens Cyclooxygenase-2 IC50 230.0 nM 10.1021/jm010484p
Homo sapiens Cyclooxygenase-2 IC50 240.0 nM 10.1016/j.bmcl.2020.127743
Homo sapiens Cyclooxygenase-2 IC50 250.0 nM 10.1016/j.ejmech.2019.03.008
Homo sapiens Cyclooxygenase-2 IC50 250.0 nM 10.1016/j.ejmech.2019.111780
Homo sapiens Cyclooxygenase-2 IC50 260.0 nM 10.1016/j.bmc.2018.07.024
Homo sapiens Cyclooxygenase-2 IC50 260.0 nM 10.1016/j.ejmech.2015.11.013
Homo sapiens Cyclooxygenase-2 IC50 270.0 nM 10.1016/j.bmcl.2020.127376
Homo sapiens Cyclooxygenase-2 IC50 270.0 nM 10.1016/j.ejmech.2014.05.012
Homo sapiens Cyclooxygenase-2 IC50 280.0 nM 10.1016/j.ejmech.2014.02.033
Homo sapiens Cyclooxygenase-2 IC50 280.0 nM 10.1016/j.ejmech.2014.04.045
Homo sapiens Cyclooxygenase-2 IC50 280.0 nM 10.1016/j.ejmech.2021.114085
Homo sapiens Cyclooxygenase-2 IC50 290.0 nM 10.1021/ml400500e
Homo sapiens Cyclooxygenase-2 IC50 300.0 nM 10.1016/j.bmc.2007.11.033
Homo sapiens Cyclooxygenase-2 IC50 300.0 nM 10.1016/j.ejmech.2007.03.030
Homo sapiens Cyclooxygenase-2 IC50 300.0 nM 10.1016/j.ejmech.2010.10.001
Homo sapiens Cyclooxygenase-2 IC50 300.0 nM 10.1016/j.ejmech.2017.09.056
Homo sapiens Cyclooxygenase-2 IC50 300.0 nM 10.1016/j.ejmech.2020.112438
Homo sapiens Cyclooxygenase-2 IC50 310.0 nM 10.1016/j.bmcl.2016.06.037
Homo sapiens Cyclooxygenase-2 IC50 320.0 nM 10.1016/j.ejmech.2013.10.032
Homo sapiens Cyclooxygenase-2 IC50 330.0 nM 10.1016/j.bmcl.2006.06.036
Homo sapiens Cyclooxygenase-2 IC50 336.0 nM 10.1016/j.bmcl.2009.02.085
Homo sapiens Cyclooxygenase-2 IC50 340.0 nM 10.1016/j.bmc.2016.11.037
Homo sapiens Cyclooxygenase-2 IC50 350.0 nM 10.1016/j.ejmech.2013.12.033
Homo sapiens Cyclooxygenase-2 IC50 350.0 nM 10.1021/jm049480l
Homo sapiens Cyclooxygenase-2 IC50 350.0 nM 10.1021/jm900702b
Homo sapiens Cyclooxygenase-2 IC50 360.0 nM 10.1016/j.bmc.2018.05.042
Homo sapiens Cyclooxygenase-2 IC50 360.0 nM 10.1016/j.bmc.2018.07.022
Homo sapiens Cyclooxygenase-2 IC50 380.0 nM 10.1016/j.ejmech.2021.113865
Homo sapiens Cyclooxygenase-2 IC50 400.0 nM 10.1016/j.bmc.2022.116633
Homo sapiens Cyclooxygenase-2 IC50 410.0 nM 10.1016/j.bmcl.2017.07.020
Homo sapiens Cyclooxygenase-2 IC50 440.0 nM 10.1021/acs.jmedchem.1c00890
Homo sapiens Cyclooxygenase-2 IC50 484.0 nM None
Homo sapiens Cyclooxygenase-2 IC50 500.0 nM None
Homo sapiens Cyclooxygenase-2 IC50 530.0 nM 10.1016/s0960-894x(00)00329-2
Homo sapiens Cyclooxygenase-2 IC50 540.0 nM 10.1016/j.bmc.2008.07.058
Homo sapiens Cyclooxygenase-2 IC50 540.0 nM 10.1016/j.bmc.2013.12.008
Homo sapiens Cyclooxygenase-2 IC50 540.0 nM 10.1021/jm0707525
Homo sapiens Cyclooxygenase-2 IC50 540.0 nM 10.1021/jm200715n
Homo sapiens Cyclooxygenase-2 IC50 540.0 nM 10.1021/jm901269y
Homo sapiens Cyclooxygenase-2 IC50 600.0 nM 10.1021/jm030765s
Homo sapiens Cyclooxygenase-2 IC50 640.0 nM 10.1016/j.bmcl.2016.12.069
Homo sapiens Cyclooxygenase-2 IC50 700.0 nM 10.1016/j.ejmech.2020.112066
Homo sapiens Cyclooxygenase-2 IC50 780.0 nM 10.1016/j.ejmech.2016.12.030
Homo sapiens Cyclooxygenase-2 IC50 780.0 nM 10.1016/j.ejmech.2020.112438
Homo sapiens Cyclooxygenase-2 IC50 790.0 nM 10.1021/acs.jnatprod.2c01153
Homo sapiens Cyclooxygenase-2 IC50 800.0 nM 10.1016/j.bmc.2008.11.074
Homo sapiens Cyclooxygenase-2 IC50 800.0 nM 10.1016/j.bmc.2010.04.034
Homo sapiens Cyclooxygenase-2 IC50 830.0 nM 10.1039/d1md00280e
Homo sapiens Cyclooxygenase-2 IC50 840.0 nM 10.1016/j.ejmech.2019.07.043
Homo sapiens Cyclooxygenase-2 IC50 870.0 nM 10.1016/j.bmc.2013.01.058
Homo sapiens Cyclooxygenase-2 IC50 870.0 nM 10.1016/j.bmc.2017.06.027
Homo sapiens Cyclooxygenase-2 IC50 870.0 nM 10.1016/j.bmcl.2015.11.105
Homo sapiens Cyclooxygenase-2 IC50 870.0 nM 10.1016/j.ejmech.2020.112438
Homo sapiens Cyclooxygenase-2 IC50 870.0 nM 10.1039/C6MD00569A
Homo sapiens Cyclooxygenase-2 IC50 880.0 nM 10.1016/j.ejmech.2016.11.006
Homo sapiens Cyclooxygenase-2 IC50 900.0 nM 10.1016/j.bmcl.2015.10.047
Homo sapiens Cyclooxygenase-2 IC50 950.0 nM 10.1016/j.ejmech.2020.112662
Homo sapiens Cyclooxygenase-2 IC50 1000.0 nM 10.1016/j.ejmech.2007.09.007
Homo sapiens Cyclooxygenase-2 IC50 1000.0 nM 10.1016/s0960-894x(03)00046-5
Homo sapiens Cyclooxygenase-2 IC50 1000.0 nM 10.1016/s0960-894x(99)00288-7
Homo sapiens Cyclooxygenase-2 IC50 1000.0 nM 10.1016/s0960-894x(99)00365-0
Homo sapiens Cyclooxygenase-2 IC50 1000.0 nM 10.1016/s0960-894x(99)00559-4
Homo sapiens Cyclooxygenase-2 IC50 1000.0 nM 10.1016/s0960-894x(99)00560-0
Homo sapiens Cyclooxygenase-2 IC50 1000.0 nM 10.1021/jm980642l
Homo sapiens Cyclooxygenase-2 IC50 1070.0 nM 10.1039/C9MD00228F
Homo sapiens Cyclooxygenase-2 IC50 1100.0 nM 10.1021/jm991106b
Homo sapiens Cyclooxygenase-2 IC50 1110.0 nM 10.1016/j.ejmech.2020.112438
Homo sapiens Cyclooxygenase-2 IC50 1140.0 nM 10.1016/j.bmcl.2017.08.023
Homo sapiens Cyclooxygenase-2 IC50 1200.0 nM 10.1016/j.bmcl.2004.09.073
Homo sapiens Cyclooxygenase-2 IC50 1200.0 nM 10.1016/j.ejmech.2007.12.017
Homo sapiens Cyclooxygenase-2 IC50 1200.0 nM 10.1021/jm030268b
Homo sapiens Cyclooxygenase-2 IC50 1200.0 nM 10.1021/jm030276s
Homo sapiens Cyclooxygenase-2 IC50 1200.0 nM 10.1021/jm0582064
Homo sapiens Cyclooxygenase-2 IC50 1200.0 nM 10.1021/jm0611861
Homo sapiens Cyclooxygenase-2 IC50 1300.0 nM 10.1021/jm0607247
Homo sapiens Cyclooxygenase-2 IC50 1310.0 nM 10.1016/j.ejmech.2019.07.016
Homo sapiens Cyclooxygenase-2 IC50 1310.0 nM 10.1021/acs.jnatprod.7b00322
Homo sapiens Cyclooxygenase-2 IC50 2270.0 nM 10.1039/d1md00280e
Homo sapiens Cyclooxygenase-2 IC50 2660.0 nM 10.1016/j.bmcl.2014.02.073
Homo sapiens Cyclooxygenase-2 IC50 2900.0 nM 10.1016/j.bmc.2008.11.018
Homo sapiens Cyclooxygenase-2 IC50 3600.0 nM 10.1021/jm010458r
Homo sapiens Cyclooxygenase-2 IC50 390000.0 nM 10.1016/j.bmc.2013.04.031
Homo sapiens Cyclooxygenase-2 IC50 430000.0 nM 10.1016/j.ejmech.2019.06.034
Homo sapiens Cyclooxygenase-2 INH 0.045 uM 10.1039/d1md00280e
Homo sapiens Cyclooxygenase-2 Inhibition 0.028 uM 10.1016/s0960-894x(98)00627-1
Homo sapiens Cyclooxygenase-2 Inhibition 0.076 % 10.1016/j.bmcl.2006.05.028
Homo sapiens Cyclooxygenase-2 Inhibition 18.98 % 10.1016/j.ejmech.2020.112918
Homo sapiens Cyclooxygenase-2 Inhibition 23.02 % 10.1016/j.ejmech.2020.112918
Homo sapiens Cyclooxygenase-2 Inhibition 30.8 % 10.1016/j.bmc.2010.01.021
Homo sapiens Cyclooxygenase-2 Inhibition 30.8 % 10.1016/j.bmc.2010.06.018
Homo sapiens Cyclooxygenase-2 Inhibition 40.0 % 10.1016/j.bmcl.2007.10.006
Homo sapiens Cyclooxygenase-2 Inhibition 42.0 % 10.1016/j.bmc.2021.116344
Homo sapiens Cyclooxygenase-2 Inhibition 48.3 % 10.1016/j.ejmech.2020.112918
Homo sapiens Cyclooxygenase-2 Inhibition 49.0 % 10.1021/np100373f
Homo sapiens Cyclooxygenase-2 Inhibition 50.0 % 10.1016/j.bmcl.2004.09.073
Homo sapiens Cyclooxygenase-2 Inhibition 50.0 % 10.1016/j.ejmech.2007.12.017
Homo sapiens Cyclooxygenase-2 Inhibition 50.0 % 10.1016/j.ejmech.2012.09.005
Homo sapiens Cyclooxygenase-2 Inhibition 50.0 % 10.1021/jm030268b
Homo sapiens Cyclooxygenase-2 Inhibition 50.0 % 10.1021/jm030276s
Homo sapiens Cyclooxygenase-2 Inhibition 55.0 % 10.1016/j.bmc.2021.116344
Homo sapiens Cyclooxygenase-2 Inhibition 60.0 % 10.1016/j.bmc.2012.03.028
Homo sapiens Cyclooxygenase-2 Inhibition 61.0 % 10.1016/j.bmc.2021.116344
Homo sapiens Cyclooxygenase-2 Inhibition 66.36 % 10.1016/j.ejmech.2013.10.032
Homo sapiens Cyclooxygenase-2 Inhibition 67.0 % 10.1021/jm0009383
Homo sapiens Cyclooxygenase-2 Inhibition 67.0 % 10.1021/jm030765s
Homo sapiens Cyclooxygenase-2 Inhibition 70.0 % 10.1016/j.bmc.2009.10.025
Homo sapiens Cyclooxygenase-2 Inhibition 70.9 % 10.1016/j.ejmech.2018.11.027
Homo sapiens Cyclooxygenase-2 Inhibition 73.0 % 10.1016/j.bmc.2021.116344
Homo sapiens Cyclooxygenase-2 Inhibition 73.1 % 10.1016/j.bmc.2014.09.028
Homo sapiens Cyclooxygenase-2 Inhibition 75.0 % 10.1016/j.ejmech.2012.06.040
Homo sapiens Cyclooxygenase-2 Inhibition 75.12 % 10.1016/j.bmc.2015.07.070
Homo sapiens Cyclooxygenase-2 Inhibition 77.19 % 10.1016/j.ejmech.2020.112918
Homo sapiens Cyclooxygenase-2 Inhibition 79.0 % 10.1021/jm401557w
Homo sapiens Cyclooxygenase-2 Inhibition 80.02 % 10.1016/j.ejmech.2020.112918
Homo sapiens Cyclooxygenase-2 Inhibition 81.2 % 10.1016/j.bmcl.2014.02.073
Homo sapiens Cyclooxygenase-2 Inhibition 83.0 % 10.1016/j.bmc.2009.12.008
Homo sapiens Cyclooxygenase-2 Inhibition 85.48 % 10.1016/j.ejmech.2020.112918
Homo sapiens Cyclooxygenase-2 Inhibition 85.6 % 10.1016/j.bmcl.2012.03.013
Homo sapiens Cyclooxygenase-2 Inhibition 90.0 % 10.1021/jm030268b
Homo sapiens Cyclooxygenase-2 Inhibition 90.0 % 10.1021/jm030276s
Homo sapiens Cyclooxygenase-2 Inhibition 90.25 % 10.1039/d1md00280e
Homo sapiens Cyclooxygenase-2 Inhibition 90.9 % 10.1016/j.ejmech.2007.02.008
Homo sapiens Cyclooxygenase-2 Inhibition 92.33 % 10.1016/j.ejmech.2020.112918
Homo sapiens Cyclooxygenase-2 Inhibition 93.0 % 10.1016/j.bmcl.2005.05.093
Homo sapiens Cyclooxygenase-2 Inhibition 93.0 % 10.1021/np100373f
Homo sapiens Cyclooxygenase-2 Inhibition 94.0 % 10.1016/j.bmc.2022.116633
Homo sapiens Cyclooxygenase-2 Inhibition 94.6 % 10.1021/jm0009383
Homo sapiens Cyclooxygenase-2 Inhibition 95.57 % 10.1016/j.bmcl.2011.01.116
Homo sapiens Cyclooxygenase-2 Inhibition 95.8 % 10.1016/j.bmc.2022.116633
Homo sapiens Cyclooxygenase-2 Inhibition 96.0 % 10.1016/j.bmc.2008.05.028
Homo sapiens Cyclooxygenase-2 Inhibition 96.0 % 10.1021/jm0705096
Homo sapiens Cyclooxygenase-2 Inhibition 96.4 % 10.1021/jm030765s
Homo sapiens Cyclooxygenase-2 Inhibition 98.0 % 10.1016/j.ejmech.2014.07.023
Homo sapiens Cyclooxygenase-2 Inhibition 98.0 % 10.1021/jm020563g
Homo sapiens Cyclooxygenase-2 Inhibition 99.0 % 10.1016/j.bmcl.2016.12.002
Homo sapiens Cyclooxygenase-2 Inhibition 99.59 % 10.1016/j.bmcl.2017.02.076
Homo sapiens Cyclooxygenase-2 Inhibition 100.0 % 10.1016/j.bmc.2009.01.029
Homo sapiens Cyclooxygenase-2 Inhibition 100.0 % 10.1016/j.bmcl.2004.01.053
Homo sapiens Cyclooxygenase-2 Inhibition 100.0 % 10.1016/j.bmcl.2004.09.073
Homo sapiens Cyclooxygenase-2 Inhibition 100.0 % 10.1016/j.bmcl.2015.01.041
Homo sapiens Cyclooxygenase-2 Inhibition 100.0 % 10.1016/j.ejmech.2007.12.017
Homo sapiens Cyclooxygenase-2 Inhibition 100.0 % 10.1021/jm020563g
Homo sapiens Cyclooxygenase-2 Inhibition 100.0 % 10.1021/jm030268b
Homo sapiens Cyclooxygenase-2 Inhibition 100.0 % 10.1021/jm030276s
Homo sapiens Cyclooxygenase-2 Inhibition 100.0 % 10.1021/ml400500e
Homo sapiens Cyclooxygenase-2 Inhibition nan % 10.1016/j.bmcl.2020.127237
Homo sapiens Cyclooxygenase-2 Inhibition nan % 10.1016/j.ejmech.2021.113566
Homo sapiens Cyclooxygenase-2 Ka 2.15 10'4/M 10.1016/j.ejmech.2014.03.003
Homo sapiens Cyclooxygenase-2 Ki 0.47 nM 10.1021/acs.jmedchem.1c00890
Homo sapiens Cyclooxygenase-2 Ki nan None None
Homo sapiens Cyclooxygenase-2 T1/2 0.71 hr 10.1021/acs.jmedchem.1c00890
Homo sapiens Cysteinyl leukotriene receptor 1 IC50 nan None None
Homo sapiens Cysteinyl leukotriene receptor 1 Ki nan None None
Homo sapiens Cytochrome c oxidase subunit 2 Activity 34.3 % 10.1021/jm200092b
Homo sapiens Cytochrome c oxidase subunit 2 Activity nan None 10.1021/jm701467e
Homo sapiens Cytochrome c oxidase subunit 2 IC50 280.0 nM 10.1016/j.ejmech.2019.111863
Homo sapiens Cytochrome c oxidase subunit 2 IC50 293.0 nM 10.1016/j.ejmech.2019.111601
Homo sapiens Cytochrome c oxidase subunit 2 IC50 540.0 nM 10.1016/j.ejmech.2017.08.046
Homo sapiens Cytochrome c oxidase subunit 2 Inhibition 56.7 % 10.1016/j.ejmech.2022.114117
Homo sapiens Cytochrome c oxidase subunit 2 Inhibition 100.0 % 10.1016/j.ejmech.2019.111601
Homo sapiens Cytochrome P450 1A2 IC50 nan None None
Homo sapiens Cytochrome P450 1A2 Inhibition 10.0 % 10.1124/dmd.111.039180
Homo sapiens Cytochrome P450 1A2 Ki nan None None
Homo sapiens Cytochrome P450 2A6 IC50 nan None None
Homo sapiens Cytochrome P450 2A6 Ki nan None None
Homo sapiens Cytochrome P450 2B6 Inhibition 10.0 % 10.1124/dmd.111.039180
Homo sapiens Cytochrome P450 2C19 IC50 nan None None
Homo sapiens Cytochrome P450 2C19 Inhibition 10.0 % 10.1124/dmd.111.039180
Homo sapiens Cytochrome P450 2C19 Ki nan None None
Homo sapiens Cytochrome P450 2C8 Inhibition 10.0 % 10.1124/dmd.111.039180
Homo sapiens Cytochrome P450 2C9 IC50 10000.0 nM 10.1021/jm070745g
Homo sapiens Cytochrome P450 2C9 IC50 nan None None
Homo sapiens Cytochrome P450 2C9 Inhibition 10.0 % 10.1124/dmd.111.039180
Homo sapiens Cytochrome P450 2C9 Ki nan None None
Homo sapiens Cytochrome P450 2C9 Stability 94.0 % 10.1021/jm0705096
Homo sapiens Cytochrome P450 2D6 IC50 1000.0 nM None
Homo sapiens Cytochrome P450 2D6 Inhibition 10.0 % 10.1124/dmd.111.039180
Homo sapiens Cytochrome P450 2D6 Ki nan None None
Homo sapiens Cytochrome P450 2E1 IC50 nan None None
Homo sapiens Cytochrome P450 2E1 Ki nan None None
Homo sapiens Cytochrome P450 3A4 IC50 nan None None
Homo sapiens Cytochrome P450 3A4 Inhibition 10.0 % 10.1124/dmd.111.039180
Homo sapiens Cytochrome P450 3A4 Ki nan None None
Homo sapiens Cytochrome P450 3A4 Potency 15848.9 nM None
Homo sapiens Delta opioid receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Delta opioid receptor IC50 nan None None
Homo sapiens Delta opioid receptor Ki nan None None
Homo sapiens Dopamine D1 receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine D1 receptor Activity 1.8 % 10.1021/jm400813y
Homo sapiens Dopamine D1 receptor IC50 27994.0 nM None
Homo sapiens Dopamine D1 receptor Inhibition 95.0 % 10.1021/jm400813y
Homo sapiens Dopamine D1 receptor Ki 13997.0 nM None
Homo sapiens Dopamine D2 receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine D2 receptor Activity 175.0 % 10.1021/jm400813y
Homo sapiens Dopamine D2 receptor IC50 nan None None
Homo sapiens Dopamine D2 receptor Inhibition 96.0 % 10.1021/jm400813y
Homo sapiens Dopamine D2 receptor Ki nan None None
Homo sapiens Dopamine D3 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine D3 receptor IC50 nan None None
Homo sapiens Dopamine D3 receptor Ki nan None None
Homo sapiens Dopamine D4 receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine D4 receptor IC50 nan None None
Homo sapiens Dopamine D4 receptor Ki nan None None
Homo sapiens Dopamine D5 receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine transporter AC50 5863.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine transporter IC50 2431.0 nM None
Homo sapiens Dopamine transporter Ki 1931.0 nM None
Homo sapiens DU-145 GI50 16255.49 nM None
Homo sapiens DU-145 IC50 59340.0 nM 10.1016/j.bmc.2022.116633
Homo sapiens EKVX GI50 17947.34 nM None
Homo sapiens Endothelin receptor ET-A AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Endothelin receptor ET-A IC50 nan None None
Homo sapiens Endothelin receptor ET-A Ki nan None None
Homo sapiens Endothelin receptor ET-B AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Epidermal growth factor receptor erbB1 IC50 nan None None
Homo sapiens Epidermal growth factor receptor erbB1 Ki nan None None
Homo sapiens Epoxide hydratase IC50 1000.0 nM 10.1021/jm2001376
Homo sapiens Epoxide hydratase IC50 261140.0 nM 10.1016/j.ejmech.2020.112662
Homo sapiens Equilibrative nucleoside transporter 1 AC50 24400.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Estrogen receptor alpha AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Estrogen receptor alpha IC50 nan None None
Homo sapiens Estrogen receptor alpha Ki nan None None
Homo sapiens Estrogen receptor alpha Potency 35481.3 nM None
Homo sapiens Estrogen receptor beta AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Estrogen receptor beta IC50 nan None None
Homo sapiens Estrogen receptor beta Ki nan None None
Homo sapiens GABA-B receptor 1 AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Gastric inhibitory polypeptide receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Geminin Potency 14581.0 nM None
Homo sapiens Geminin Potency 31622.8 nM None
Homo sapiens Ghrelin receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Glucagon-like peptide 1 receptor Potency 28183.8 nM None
Homo sapiens Glucagon receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Glucocorticoid receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Glucocorticoid receptor IC50 nan None None
Homo sapiens Glucocorticoid receptor Ki nan None None
Homo sapiens Glucocorticoid receptor Potency 28183.8 nM None
Homo sapiens HCC 2998 GI50 15667.51 nM None
Homo sapiens HCT-116 GI50 54954.09 nM None
Homo sapiens HCT-116 IC50 29540.0 nM 10.1016/j.ejmech.2018.09.007
Homo sapiens HCT-116 IC50 43300.0 nM 10.1021/jm101330h
Homo sapiens HCT-116 Inhibition nan % 10.1021/jm101330h
Homo sapiens HCT-15 GI50 15922.09 nM None
Homo sapiens HEK293 IC50 nan None 10.1016/j.bmc.2020.115960
Homo sapiens HEK-293T CC50 54380.0 nM 10.1016/j.bmcl.2015.08.026
Homo sapiens HEK-293T CC50 55830.0 nM 10.1016/j.bmcl.2018.05.004
Homo sapiens HEK-293T CC50 72420.0 nM 10.1016/j.bmcl.2015.03.022
Homo sapiens HEK-293T IC50 97870.0 nM 10.1016/j.ejmech.2019.03.008
Homo sapiens HEK-293T IC50 111860.0 nM 10.1016/j.bmcl.2017.07.020
Homo sapiens HEK-293T IC50 224860.0 nM 10.1016/j.bmc.2018.07.022
Homo sapiens HeLa Activity 50.0 % 10.1016/j.bmc.2013.10.006
Homo sapiens HeLa Activity nan None 10.1016/j.bmc.2013.10.006
Homo sapiens HeLa IC50 7350.0 nM 10.1016/j.bmcl.2015.03.022
Homo sapiens HeLa IC50 7550.0 nM 10.1016/j.bmcl.2015.08.026
Homo sapiens HeLa IC50 7550.0 nM 10.1016/j.bmcl.2018.05.004
Homo sapiens HeLa IC50 7790.0 nM 10.1016/j.bmcl.2016.06.037
Homo sapiens HeLa IC50 11060.0 nM 10.1016/j.bmcl.2017.07.020
Homo sapiens HeLa IC50 15680.0 nM 10.1016/j.ejmech.2019.03.008
Homo sapiens HeLa IC50 15690.0 nM 10.1016/j.bmc.2018.07.022
Homo sapiens HeLa IC50 32700.0 nM 10.1016/j.bmcl.2023.129129
Homo sapiens HeLa IC50 36080.0 nM 10.1016/j.ejmech.2018.09.007
Homo sapiens HeLa IC50 58200.0 nM 10.1016/j.bmc.2022.116633
Homo sapiens HeLa Inhibition nan % 10.1016/j.bmcl.2016.06.037
Homo sapiens HepG2 Activity nan None 10.1016/j.bmc.2022.116633
Homo sapiens HepG2 IC50 360.0 nM 10.1016/j.ejmech.2020.112439
Homo sapiens HepG2 IC50 760.0 nM 10.1016/j.bmcl.2015.08.026
Homo sapiens HepG2 IC50 780.0 nM 10.1016/j.bmcl.2018.05.004
Homo sapiens HepG2 IC50 10030.0 nM 10.1016/j.bmcl.2016.06.037
Homo sapiens HepG2 IC50 43600.0 nM 10.1016/j.bmcl.2023.129129
Homo sapiens HepG2 IC50 58200.0 nM 10.1016/j.bmc.2022.116633
Homo sapiens HepG2 IC50 95500.0 nM 10.1016/j.bmc.2011.09.034
Homo sapiens HepG2 Inhibition 77.88 % 10.1016/j.ejmech.2020.112439
Homo sapiens HepG2 Potency 22387.2 nM None
Homo sapiens HERG AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens HERG IC50 nan None None
Homo sapiens HERG Ki nan None None
Homo sapiens HERG Potency 50118.7 nM None
Homo sapiens Histamine H1 receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Histamine H1 receptor IC50 nan None None
Homo sapiens Histamine H1 receptor Ki nan None None
Homo sapiens Histamine H2 receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Histamine H2 receptor IC50 nan None None
Homo sapiens Histamine H2 receptor Ki nan None None
Homo sapiens Histamine H3 receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Histone deacetylase IC50 1637.0 nM 10.1016/j.bmc.2017.08.029
Homo sapiens Histone deacetylase 1 IC50 1185.0 nM 10.1016/j.bmc.2017.08.029
Homo sapiens Histone deacetylase 2 IC50 nan None 10.1016/j.bmc.2017.08.029
Homo sapiens Histone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2) IC50 nan None 10.1016/j.bmc.2017.08.029
Homo sapiens Histone deacetylase 6 IC50 643.0 nM 10.1016/j.bmc.2017.08.029
Homo sapiens Histone deacetylase 6 Inhibition -64.0 % 10.6019/CHEMBL4808148
Homo sapiens Histone deacetylase 6 Inhibition 4.28 % 10.6019/CHEMBL4808148
Homo sapiens Histone deacetylase 8 IC50 nan None 10.1016/j.bmc.2017.08.029
Homo sapiens HL-60 GI50 14757.07 nM None
Homo sapiens HL-60 IC50 44720.0 nM 10.1016/j.bmc.2022.117085
Homo sapiens HL-60 IC50 nan None 10.1016/j.bmc.2010.01.021
Homo sapiens HMG-CoA reductase IC50 nan None None
Homo sapiens HMG-CoA reductase Ki nan None None
Homo sapiens Homo sapiens DILI_Concern nan None 10.1016/j.drudis.2016.02.015
Homo sapiens Homo sapiens DILI_severity_class 3.0 None 10.1016/j.drudis.2016.02.015
Homo sapiens Homo sapiens IC50 164.0 nM 10.1021/jm990577v
Homo sapiens Homo sapiens IC50 6670.0 nM 10.1021/jm990577v
Homo sapiens Homo sapiens IC50 19000.0 nM 10.1021/jm9906015
Homo sapiens Homo sapiens Inhibition 7.7 % 10.1016/j.ejmech.2017.08.048
Homo sapiens Homo sapiens Inhibition 8.1 % 10.1016/j.ejmech.2017.08.048
Homo sapiens Homo sapiens T1/2 11.2 hr 10.1021/jm800219f
Homo sapiens HOP-62 GI50 67920.36 nM None
Homo sapiens Hs-578T GI50 18535.32 nM None
Homo sapiens HT-29 GI nan None 10.1016/j.bmc.2013.02.033
Homo sapiens HT-29 GI50 16519.62 nM None
Homo sapiens HT-29 IC50 18.0 ug.mL-1 10.1016/j.bmc.2012.06.018
Homo sapiens HT-29 IC50 700.0 nM 10.1016/j.bmcl.2013.11.015
Homo sapiens HT-29 IC50 3000.0 nM 10.1016/j.bmc.2013.02.033
Homo sapiens HT-29 IC50 5700.0 nM 10.1016/j.bmcl.2013.11.015
Homo sapiens HT-29 IC50 8470.0 nM 10.1016/j.bmcl.2017.07.020
Homo sapiens HT-29 IC50 17970.0 nM 10.1016/j.bmc.2020.115960
Homo sapiens HT-29 IC50 45500.0 nM 10.1021/jm100398z
Homo sapiens HT-29 Inhibition nan % 10.1016/j.bmc.2013.02.033
Homo sapiens HT-29 Ratio IC50 8.0 None 10.1016/j.bmcl.2013.11.015
Homo sapiens HUVEC Activity nan None 10.1016/j.bmc.2022.117085
Homo sapiens Hydroxycarboxylic acid receptor 2 AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens IGROV-1 GI50 15417.0 nM None
Homo sapiens Interleukin-8 receptor A IC50 nan None None
Homo sapiens Interleukin-8 receptor A Ki nan None None
Homo sapiens Interleukin-8 receptor B IC50 nan None None
Homo sapiens Interleukin-8 receptor B Ki nan None None
Homo sapiens Isocitrate dehydrogenase [NADP] cytoplasmic Potency 23109.3 nM None
Homo sapiens Jurkat IC50 32130.0 nM 10.1016/j.bmc.2022.117085
Homo sapiens K562 GI50 10069.32 nM None
Homo sapiens K562 IC50 57810.0 nM 10.1016/j.bmc.2022.117085
Homo sapiens K562 Inhibition 38.8 % 10.1021/jm100398z
Homo sapiens Kappa opioid receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Kappa opioid receptor IC50 nan None None
Homo sapiens Kappa opioid receptor Ki nan None None
Homo sapiens KM12 GI50 15066.07 nM None
Homo sapiens L02 CC50 78200.0 nM 10.1016/j.bmcl.2018.05.004
Homo sapiens Leukocyte common antigen IC50 nan None None
Homo sapiens Leukocyte common antigen Ki nan None None
Homo sapiens Leukocyte elastase IC50 nan None None
Homo sapiens Leukocyte elastase Ki nan None None
Homo sapiens Liver microsome CLH nan None 10.1124/dmd.111.039180
Homo sapiens Liver microsome Drug metabolism nan None 10.1124/dmd.111.039180
Homo sapiens Liver microsome PB 13.0 pmol 10.1124/dmd.111.039180
Homo sapiens LNCaP Activity 0.35 % 10.1016/j.bmc.2016.12.032
Homo sapiens LNCaP Activity 0.59 % 10.1016/j.bmc.2016.12.032
Homo sapiens LNCaP Activity 0.85 % 10.1016/j.bmc.2016.12.032
Homo sapiens LNCaP Activity 3.9 % 10.1021/jm0407761
Homo sapiens LNCaP Activity 4.0 % 10.1021/jm0407761
Homo sapiens LNCaP Activity 6.9 % 10.1021/jm0407761
Homo sapiens LNCaP Activity 9.0 % 10.1021/jm0407761
Homo sapiens LNCaP Activity 11.1 % 10.1021/jm0407761
Homo sapiens LNCaP Activity 11.3 % 10.1021/jm0407761
Homo sapiens LNCaP Activity 28.4 % 10.1016/j.bmc.2016.12.032
Homo sapiens LNCaP Activity 69.2 % 10.1016/j.bmc.2016.12.032
Homo sapiens LNCaP Activity 75.7 % 10.1021/jm0407761
Homo sapiens LNCaP Activity 78.0 % 10.1021/jm0407761
Homo sapiens LNCaP IC50 16400.0 nM 10.1016/j.bmc.2022.116633
Homo sapiens LNCaP IC50 50400.0 nM 10.1021/jm0407761
Homo sapiens LOX IMVI GI50 18155.16 nM None
Homo sapiens Lymphoblastoid cell Potency 19952.6 nM None
Homo sapiens M14 GI50 67920.36 nM None
Homo sapiens Malme-3M GI50 18620.87 nM None
Homo sapiens MAP kinase ERK1 IC50 nan None None
Homo sapiens MAP kinase ERK1 Ki nan None None
Homo sapiens MAP kinase ERK2 IC50 nan None None
Homo sapiens MAP kinase ERK2 Ki nan None None
Homo sapiens MAP kinase p38 alpha IC50 810.0 nM 10.1016/j.bmcl.2005.05.107
Homo sapiens MAP kinase p38 alpha IC50 nan None None
Homo sapiens MAP kinase p38 alpha Ki nan None None
Homo sapiens Matrix metalloproteinase-1 IC50 nan None None
Homo sapiens Matrix metalloproteinase-1 Ki nan None None
Homo sapiens Matrix metalloproteinase 9 IC50 nan None None
Homo sapiens Matrix metalloproteinase 9 Ki nan None None
Homo sapiens MCF-10A IC50 nan None 10.1016/j.bmc.2020.115960
Homo sapiens MCF7 GI50 17538.81 nM None
Homo sapiens MCF7 IC50 2560.0 nM 10.1016/j.ejmech.2020.112439
Homo sapiens MCF7 IC50 5940.0 nM 10.1016/j.bmcl.2015.03.022
Homo sapiens MCF7 IC50 6880.0 nM 10.1016/j.bmcl.2015.08.026
Homo sapiens MCF7 IC50 6960.0 nM 10.1016/j.bmcl.2018.05.004
Homo sapiens MCF7 IC50 12570.0 nM 10.1016/j.ejmech.2019.03.008
Homo sapiens MCF7 IC50 15980.0 nM 10.1016/j.bmc.2020.115960
Homo sapiens MCF7 IC50 19780.0 nM 10.1016/j.bmc.2020.115960
Homo sapiens MCF7 IC50 26780.0 nM 10.1016/j.bmc.2018.07.022
Homo sapiens MCF7 IC50 31280.0 nM 10.1016/j.ejmech.2018.09.007
Homo sapiens MCF7 IC50 40800.0 nM 10.1016/j.bmc.2011.09.034
Homo sapiens MCF7 IC50 40800.0 nM 10.1016/j.ejmech.2012.11.021
Homo sapiens MCF7 IC50 49660.0 nM 10.1016/j.bmc.2017.11.027
Homo sapiens MCF7 IC50 50200.0 nM 10.1016/j.bmc.2010.04.034
Homo sapiens MCF7 IC50 64190.0 nM 10.1016/j.bmc.2022.116633
Homo sapiens MCF7 Inhibition 89.86 % 10.1016/j.ejmech.2020.112439
Homo sapiens MDA-MB-231 Activity 11.43 % 10.1016/j.bmcl.2014.07.058
Homo sapiens MDA-MB-231 Activity 17.33 % 10.1016/j.bmcl.2014.07.058
Homo sapiens MDA-MB-231 GI50 15595.53 nM None
Homo sapiens MDA-MB-231 IC50 22790.0 nM 10.1016/j.ejmech.2018.09.007
Homo sapiens MDA-MB-231 IC50 40000.0 nM 10.1021/jm300576q
Homo sapiens MDA-MB-231 IC50 69640.0 nM 10.1016/j.bmc.2022.116633
Homo sapiens MDA-MB-231 OD 0.27 nm 10.1016/j.bmcl.2014.07.058
Homo sapiens MDA-MB-435 GI50 17458.22 nM None
Homo sapiens MDA-N GI50 17139.57 nM None
Homo sapiens Melanocortin receptor 3 AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Melanocortin receptor 3 IC50 nan None None
Homo sapiens Melanocortin receptor 3 Ki nan None None
Homo sapiens Melanocortin receptor 4 AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Melanocortin receptor 4 IC50 nan None None
Homo sapiens Melanocortin receptor 4 Ki nan None None
Homo sapiens Melanocortin receptor 5 IC50 nan None None
Homo sapiens Melanocortin receptor 5 Ki nan None None
Homo sapiens MOLT-4 GI50 17258.38 nM None
Homo sapiens Monoamine oxidase A AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Monoamine oxidase A IC50 nan None None
Homo sapiens Monoamine oxidase A Ki nan None None
Homo sapiens MONO-MAC-6 Inhibition 85.0 % 10.1016/j.bmc.2008.11.074
Homo sapiens Mothers against decapentaplegic homolog 3 Potency 35481.3 nM None
Homo sapiens Motilin receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Multidrug resistance-associated protein 4 Activity 78.0 % 10.1073/pnas.1033060100
Homo sapiens Multidrug resistance-associated protein 4 Activity nan None 10.1038/nrd3028
Homo sapiens Multidrug resistance-associated protein 4 IC50 133000.0 nM 10.1093/toxsci/kft176
Homo sapiens Mu opioid receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Mu opioid receptor IC50 nan None None
Homo sapiens Mu opioid receptor Ki nan None None
Homo sapiens Muscarinic acetylcholine receptor M1 AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Muscarinic acetylcholine receptor M1 IC50 nan None None
Homo sapiens Muscarinic acetylcholine receptor M1 Ki nan None None
Homo sapiens Muscarinic acetylcholine receptor M2 AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Muscarinic acetylcholine receptor M2 IC50 nan None None
Homo sapiens Muscarinic acetylcholine receptor M2 Ki nan None None
Homo sapiens Muscarinic acetylcholine receptor M3 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Muscarinic acetylcholine receptor M3 IC50 nan None None
Homo sapiens Muscarinic acetylcholine receptor M3 Ki nan None None
Homo sapiens Muscarinic acetylcholine receptor M4 AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Muscarinic acetylcholine receptor M4 IC50 nan None None
Homo sapiens Muscarinic acetylcholine receptor M4 Ki nan None None
Homo sapiens Muscarinic acetylcholine receptor M5 AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Muscarinic acetylcholine receptor M5 IC50 nan None None
Homo sapiens Muscarinic acetylcholine receptor M5 Ki nan None None
Homo sapiens Myeloperoxidase Inhibition 11.02 % 10.1021/acs.jmedchem.7b00285
Homo sapiens NALM-6 IC50 28580.0 nM 10.1016/j.bmc.2022.117085
Homo sapiens NCI/ADR-RES GI50 16180.8 nM None
Homo sapiens NCI-H23 GI50 17139.57 nM None
Homo sapiens NCI-H322M GI50 18155.16 nM None
Homo sapiens NCI-H460 GI50 15848.93 nM None
Homo sapiens NCI-H460 Inhibition 9.75 % 10.1021/jm100398z
Homo sapiens Neurokinin 1 receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Neurokinin 1 receptor IC50 nan None None
Homo sapiens Neurokinin 1 receptor Ki nan None None
Homo sapiens Neurokinin 2 receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Neurokinin 2 receptor IC50 nan None None
Homo sapiens Neurokinin 2 receptor Ki nan None None
Homo sapiens Neuronal acetylcholine receptor protein alpha-4 subunit AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Neuropeptide Y receptor type 1 AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Neuropeptide Y receptor type 1 IC50 nan None None
Homo sapiens Neuropeptide Y receptor type 1 Ki nan None None
Homo sapiens Neuropeptide Y receptor type 2 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Neuropeptide Y receptor type 2 IC50 nan None None
Homo sapiens Neuropeptide Y receptor type 2 Ki nan None None
Homo sapiens Neurotensin receptor 1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Norepinephrine transporter AC50 15700.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Norepinephrine transporter IC50 7308.0 nM None
Homo sapiens Norepinephrine transporter Ki 7247.0 nM None
Homo sapiens Nuclear factor erythroid 2-related factor 2 Potency 25929.0 nM None
Homo sapiens Nuclear factor erythroid 2-related factor 2 Potency 66824.2 nM None
Homo sapiens Nuclear receptor ROR-gamma Potency 33491.5 nM None
Homo sapiens OVCAR-3 GI50 17579.24 nM None
Homo sapiens OVCAR-4 GI50 12387.97 nM None
Homo sapiens OVCAR-5 GI50 19724.23 nM None
Homo sapiens OVCAR-8 GI50 19724.23 nM None
Homo sapiens PC-3 Activity 2.4 % 10.1021/jm0407761
Homo sapiens PC-3 Activity 5.8 % 10.1021/jm0407761
Homo sapiens PC-3 Activity 23.5 % 10.1021/jm0407761
Homo sapiens PC-3 Activity 68.5 % 10.1021/jm0407761
Homo sapiens PC-3 FC 0.902 None 10.1038/nchembio790
Homo sapiens PC-3 GI50 13396.77 nM None
Homo sapiens PC-3 GI50 47000.0 nM 10.1016/j.ejmech.2007.12.017
Homo sapiens PC-3 IC50 47000.0 nM 10.1021/jm0407761
Homo sapiens PC-3 IC50 48000.0 nM 10.1016/j.ejmech.2007.08.005
Homo sapiens PC-3 IC50 48500.0 nM 10.1016/j.bmc.2010.04.034
Homo sapiens Peroxisome proliferator-activated receptor delta Potency 35481.3 nM None
Homo sapiens Peroxisome proliferator-activated receptor gamma Potency 50118.7 nM None
Homo sapiens Phosphodiesterase 3A AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Phosphodiesterase 4D AC50 20000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Phosphodiesterase 5A IC50 36000.0 nM None
Homo sapiens Phosphodiesterase 5A IC50 37000.0 nM 10.1021/acs.jmedchem.0c01120
Homo sapiens Phosphodiesterase 5A IC50 100000.0 nM 10.1021/acs.jmedchem.0c01120
Homo sapiens Phosphodiesterase 5A IC50 nan None None
Homo sapiens Phosphodiesterase 5A Ki nan None None
Homo sapiens Phosphodiesterase 6A AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Plasma Cp 1.0 uM 10.1021/jm300576q
Homo sapiens Platelet activating factor receptor IC50 nan None None
Homo sapiens Platelet activating factor receptor Ki nan None None
Homo sapiens Prelamin-A/C Potency 35481.3 nM None
Homo sapiens Progesterone receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Prostaglandin E synthase Activity nan None 10.1021/jm801085s
Homo sapiens Prostaglandin E synthase IC50 425.0 nM 10.1021/acs.jmedchem.5b01249
Homo sapiens Prostaglandin E synthase IC50 540.0 nM 10.1016/j.bmcl.2016.08.023
Homo sapiens Prostaglandin E synthase IC50 540.0 nM 10.1021/acs.jmedchem.5b01249
Homo sapiens Prostaglandin E synthase Inhibition nan % 10.1016/j.bmc.2009.10.025
Homo sapiens Prostaglandin E synthase Inhibition nan % 10.1016/j.bmc.2013.10.006
Homo sapiens Prostaglandin E synthase Inhibition nan % 10.1021/jm201687d
Homo sapiens Protein kinase C alpha IC50 nan None None
Homo sapiens Protein kinase C alpha Ki nan None None
Homo sapiens Rap guanine nucleotide exchange factor 4 Potency 44668.4 nM None
Homo sapiens Receptor protein-tyrosine kinase erbB-2 IC50 nan None None
Homo sapiens Receptor protein-tyrosine kinase erbB-2 Ki nan None None
Homo sapiens Retinoid X receptor alpha Potency 22387.2 nM None
Homo sapiens RPMI-8226 GI50 3845.92 nM None
Homo sapiens RXF 393 GI50 17100.15 nM None
Homo sapiens Serine/threonine protein phosphatase 2B catalytic subunit, alpha isoform IC50 nan None None
Homo sapiens Serine/threonine protein phosphatase 2B catalytic subunit, alpha isoform Ki nan None None
Homo sapiens Serotonin 1a (5-HT1a) receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2a (5-HT2a) receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2a (5-HT2a) receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2a (5-HT2a) receptor IC50 nan None None
Homo sapiens Serotonin 2a (5-HT2a) receptor Ki nan None None
Homo sapiens Serotonin 2b (5-HT2b) receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2b (5-HT2b) receptor IC50 nan None None
Homo sapiens Serotonin 2b (5-HT2b) receptor Ki nan None None
Homo sapiens Serotonin 2c (5-HT2c) receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2c (5-HT2c) receptor IC50 nan None None
Homo sapiens Serotonin 2c (5-HT2c) receptor Ki nan None None
Homo sapiens Serotonin 3a (5-HT3a) receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 5a (5-HT5a) receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 6 (5-HT6) receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 6 (5-HT6) receptor IC50 nan None None
Homo sapiens Serotonin 6 (5-HT6) receptor Ki nan None None
Homo sapiens Serotonin 7 (5-HT7) receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin transporter AC50 2300.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin transporter IC50 6276.0 nM None
Homo sapiens Serotonin transporter Ki 3334.0 nM None
Homo sapiens SF-268 GI50 16865.53 nM None
Homo sapiens SF-295 GI50 16557.7 nM None
Homo sapiens SF-539 GI50 18113.4 nM None
Homo sapiens SH-SY5Y IC50 5000.0 nM 10.1016/j.bmc.2010.01.021
Homo sapiens Sigma opioid receptor IC50 nan None None
Homo sapiens Sigma opioid receptor Ki nan None None
Homo sapiens Signal transducer and activator of transcription 3 Inhibition nan % 10.1021/jm101330h
Homo sapiens SK-MEL-2 GI50 16106.46 nM None
Homo sapiens SK-MEL-28 GI50 17619.76 nM None
Homo sapiens SK-MEL-5 GI50 14791.08 nM None
Homo sapiens SK-OV-3 GI50 18281.0 nM None
Homo sapiens SMMC-7721 IC50 5960.0 nM 10.1016/j.bmcl.2017.07.020
Homo sapiens SN12C GI50 15631.48 nM None
Homo sapiens SNB-19 GI50 17988.71 nM None
Homo sapiens SNB-75 GI50 15559.66 nM None
Homo sapiens Solute carrier family 22 member 1 Inhibition 7.7 % 10.1021/jm8003152
Homo sapiens Solute carrier organic anion transporter family member 1B1 Inhibition -3.3 % 10.1021/jm300212s
Homo sapiens Solute carrier organic anion transporter family member 1B1 Inhibition 108.3 % 10.1124/mol.112.084152
Homo sapiens Solute carrier organic anion transporter family member 1B3 Inhibition 22.3 % 10.1021/jm300212s
Homo sapiens Solute carrier organic anion transporter family member 1B3 Inhibition 142.84 % 10.1124/mol.112.084152
Homo sapiens Solute carrier organic anion transporter family member 2B1 Inhibition -69.0 % 10.1021/jm300212s
Homo sapiens SR GI50 16069.41 nM None
Homo sapiens SUM149PT Activity 0.13 pg/ml 10.1016/j.bmcl.2011.08.050
Homo sapiens SUM149PT Activity 0.43 pg/ml 10.1016/j.bmcl.2011.08.050
Homo sapiens SUM149PT Activity 1.19 pg/ml 10.1016/j.bmcl.2011.08.050
Homo sapiens SW480 IC50 6900.0 nM 10.1016/j.bmcl.2013.11.015
Homo sapiens SW-620 GI50 16865.53 nM None
Homo sapiens T47D GI50 16788.04 nM None
Homo sapiens THP-1 Activity nan None 10.1016/j.bmc.2009.12.008
Homo sapiens THP-1 EC50 50000.0 nM 10.1016/j.bmc.2010.01.021
Homo sapiens THP-1 EC50 50000.0 nM 10.1016/j.bmc.2010.06.018
Homo sapiens THP-1 IC50 5000.0 nM 10.1016/j.bmc.2010.06.018
Homo sapiens THP-1 IC50 70000.0 nM 10.1016/j.bmc.2010.06.018
Homo sapiens THP-1 Inhibition nan % 10.1016/j.bmc.2010.01.021
Homo sapiens Thromboxane A2 receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Thromboxane-A synthase IC50 nan None None
Homo sapiens Thromboxane-A synthase Ki nan None None
Homo sapiens Thyroid hormone receptor beta-1 Potency 10000.0 nM None
Homo sapiens Thyroid stimulating hormone receptor Potency 794.3 nM None
Homo sapiens TK-10 GI50 18836.49 nM None
Homo sapiens Type-1 angiotensin II receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Tyrosine-protein kinase FYN IC50 nan None None
Homo sapiens Tyrosine-protein kinase FYN Ki nan None None
Homo sapiens Tyrosine-protein kinase LCK IC50 nan None None
Homo sapiens Tyrosine-protein kinase LCK Ki nan None None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 9200.0 nM None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 11885.6 nM None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 29092.9 nM None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 33498.3 nM None
Homo sapiens U-251 GI50 16143.59 nM None
Homo sapiens U-251 IC50 40000.0 nM 10.1016/j.ejmech.2021.113564
Homo sapiens U-87 MG IC50 40000.0 nM 10.1016/j.ejmech.2021.113564
Homo sapiens UACC-257 GI50 19724.23 nM None
Homo sapiens UACC-62 GI50 15381.55 nM None
Homo sapiens UACC-903 IC50 55600.0 nM 10.1016/j.ejmech.2021.113621
Homo sapiens Ubiquitin carboxyl-terminal hydrolase 1 Potency 44668.4 nM None
Homo sapiens Ubiquitin carboxyl-terminal hydrolase 1 Potency 50118.7 nM None
Homo sapiens UO-31 GI50 14825.18 nM None
Homo sapiens Vanilloid receptor IC50 10000.0 nM 10.1016/j.bmcl.2022.129101
Homo sapiens Vascular endothelial growth factor receptor 1 IC50 nan None None
Homo sapiens Vascular endothelial growth factor receptor 1 Ki nan None None
Homo sapiens Vasoactive intestinal polypeptide receptor 1 IC50 nan None None
Homo sapiens Vasoactive intestinal polypeptide receptor 1 Ki nan None None
Homo sapiens Vasopressin V1a receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Vasopressin V1a receptor IC50 nan None None
Homo sapiens Vasopressin V1a receptor Ki nan None None
Homo sapiens Vasopressin V2 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens WI-38 IC50 432900.0 nM 10.1016/j.ejmech.2020.112439
Homo sapiens WM-115 IC50 55600.0 nM 10.1016/j.ejmech.2021.113621
Klebsiella pneumoniae Klebsiella pneumoniae Inhibition 10.55 % 10.6019/CHEMBL4513141
Methanobacterium thermoautotrophicum Carbonic anhydrase Ki 38500.0 nM 10.1016/j.bmcl.2004.09.085
Methanosarcina thermophila Carbonic anhydrase Ki 140.0 nM 10.1016/j.bmcl.2004.09.085
Methanosarcina thermophila Carbonic anhydrase Ki 1010.0 nM 10.1016/j.bmcl.2004.09.085
Mus musculus B16-F10 Activity 978.35 mm3 10.1016/j.ejmech.2019.03.008
Mus musculus B16-F10 Activity nan None 10.1016/j.ejmech.2019.03.008
Mus musculus B16-F10 IC50 13270.0 nM 10.1016/j.ejmech.2019.03.008
Mus musculus B16-F10 IC50 16200.0 nM 10.1016/j.bmcl.2021.128240
Mus musculus B16-F10 IC50 19150.0 nM 10.1016/j.bmc.2018.07.022
Mus musculus B16-F10 IC50 85600.0 nM 10.1016/j.bmc.2011.09.034
Mus musculus B16-F10 IC50 85900.0 nM 10.1016/j.ejmech.2012.11.021
Mus musculus B16-F10 Inhibition nan % 10.1016/j.ejmech.2019.03.008
Mus musculus Cadherin-11 Activity nan None 10.1021/jm300576q
Mus musculus Carbonic anhydrase 15 Ki 45.0 nM 10.1016/j.bmcl.2010.06.082
Mus musculus Carbonic anhydrase 15 Ki 45.0 nM 10.1021/jm801267c
Mus musculus Cyclooxygenase-1 IC50 0.7 nM 10.1021/jm990965x
Mus musculus Cyclooxygenase-1 IC50 1.86 ug.mL-1 10.1016/s0960-894x(00)00634-x
Mus musculus Cyclooxygenase-1 IC50 1.86 ug.mL-1 10.1021/jm020545z
Mus musculus Cyclooxygenase-1 IC50 3700.0 nM 10.1016/j.bmc.2008.07.058
Mus musculus Cyclooxygenase-1 IC50 3700.0 nM 10.1021/jm0707525
Mus musculus Cyclooxygenase-1 IC50 3840.0 nM 10.1016/j.bmc.2013.04.031
Mus musculus Cyclooxygenase-1 IC50 3840.0 nM 10.1016/j.ejmech.2022.114615
Mus musculus Cyclooxygenase-1 IC50 3840.0 nM 10.1021/jm200715n
Mus musculus Cyclooxygenase-1 IC50 5100.0 nM 10.1021/jm049121q
Mus musculus Cyclooxygenase-1 IC50 5100.0 nM 10.1021/jm901269y
Mus musculus Cyclooxygenase-1 Inhibition 0.0 % 10.1021/jm200715n
Mus musculus Cyclooxygenase-1 Inhibition 4.0 % 10.1021/jm200715n
Mus musculus Cyclooxygenase-1 Inhibition 31.0 % 10.1021/jm200715n
Mus musculus Cyclooxygenase-1 Inhibition 64.7 % 10.1021/jm200715n
Mus musculus Cyclooxygenase-1 Inhibition 76.0 % 10.1016/s0960-894x(02)00952-6
Mus musculus Cyclooxygenase-1 Inhibition 79.0 % 10.1016/j.bmcl.2004.02.028
Mus musculus Cyclooxygenase-2 IC50 0.01 ug.mL-1 10.1016/j.bmcl.2004.02.028
Mus musculus Cyclooxygenase-2 IC50 0.01 ug.mL-1 10.1016/s0960-894x(02)00952-6
Mus musculus Cyclooxygenase-2 IC50 0.02 ug.mL-1 10.1016/s0960-894x(00)00634-x
Mus musculus Cyclooxygenase-2 IC50 0.02 ug.mL-1 10.1021/jm020545z
Mus musculus Cyclooxygenase-2 IC50 0.51 nM 10.1021/np060287z
Mus musculus Cyclooxygenase-2 IC50 3.2 nM 10.1021/acs.jmedchem.1c00890
Mus musculus Cyclooxygenase-2 IC50 8.7 nM 10.1016/j.bmcl.2014.02.074
Mus musculus Cyclooxygenase-2 IC50 9.3 nM 10.1021/jm990965x
Mus musculus Cyclooxygenase-2 IC50 30.0 nM 10.1021/ml100232q
Mus musculus Cyclooxygenase-2 IC50 39.81 nM 10.1021/jm020089e
Mus musculus Cyclooxygenase-2 IC50 60.0 nM 10.1016/j.bmc.2008.07.058
Mus musculus Cyclooxygenase-2 IC50 60.0 nM 10.1021/jm0707525
Mus musculus Cyclooxygenase-2 IC50 61.0 nM 10.1016/j.bmc.2013.04.031
Mus musculus Cyclooxygenase-2 IC50 61.0 nM 10.1016/j.ejmech.2022.114615
Mus musculus Cyclooxygenase-2 IC50 61.0 nM 10.1021/jm200715n
Mus musculus Cyclooxygenase-2 IC50 79.0 nM 10.1021/jm049121q
Mus musculus Cyclooxygenase-2 IC50 79.0 nM 10.1021/jm901269y
Mus musculus Cyclooxygenase-2 IC50 120.0 nM 10.1016/j.ejmech.2012.11.021
Mus musculus Cyclooxygenase-2 IC50 25000.0 nM 10.1016/j.bmc.2006.12.041
Mus musculus Cyclooxygenase-2 IC50 80000.0 nM 10.1021/jm901269y
Mus musculus Cyclooxygenase-2 IC50 95000.0 nM 10.1021/jm901269y
Mus musculus Cyclooxygenase-2 IC50 nan None 10.1021/ml100232q
Mus musculus Cyclooxygenase-2 Inhibition 8.9 % 10.1016/j.bmcl.2017.02.076
Mus musculus Cyclooxygenase-2 Inhibition 32.0 % 10.1021/jm200715n
Mus musculus Cyclooxygenase-2 Inhibition 52.0 % 10.1021/jm200715n
Mus musculus Cyclooxygenase-2 Inhibition 67.0 % 10.1021/jm049121q
Mus musculus Cyclooxygenase-2 Inhibition 75.0 % 10.1016/j.bmc.2012.03.028
Mus musculus Cyclooxygenase-2 Inhibition 80.0 % 10.1016/j.bmc.2008.07.058
Mus musculus Cyclooxygenase-2 Inhibition 80.0 % 10.1021/jm0707525
Mus musculus Cyclooxygenase-2 Inhibition 80.0 % 10.1021/jm200715n
Mus musculus Cyclooxygenase-2 Inhibition 96.4 % 10.1021/jm049121q
Mus musculus Cyclooxygenase-2 Inhibition 99.0 % 10.1016/j.bmcl.2010.05.092
Mus musculus Cyclooxygenase-2 Inhibition 100.0 % 10.1016/j.bmc.2008.07.058
Mus musculus Cyclooxygenase-2 Inhibition 100.0 % 10.1016/j.bmc.2009.01.029
Mus musculus Cyclooxygenase-2 Inhibition 100.0 % 10.1021/jm0707525
Mus musculus Cyclooxygenase-2 Inhibition 100.0 % 10.1021/jm200715n
Mus musculus Cyclooxygenase-2 Inhibition nan % 10.1021/acs.jmedchem.2c00817
Mus musculus Cyclooxygenase-2 Ki 7.34 None 10.1021/jm020089e
Mus musculus L1210 IC50 44000.0 nM 10.1016/j.bmc.2010.04.034
Mus musculus MC9 Activity nan None 10.1021/jm701467e
Mus musculus MC9 Activity nan None 10.1021/jm8009876
Mus musculus MC9 IC50 300.0 nM 10.1021/jm701467e
Mus musculus MC9 IC50 400.0 nM 10.1021/jm701467e
Mus musculus MC9 Inhibition 50.0 % 10.1021/jm8009876
Mus musculus MC9 Inhibition 79.0 % 10.1021/jm8009876
Mus musculus Mus musculus Activity 9.79 mg 10.1016/j.bmc.2021.116344
Mus musculus Mus musculus Activity 17.0 % 10.1016/j.bmc.2013.12.008
Mus musculus Mus musculus Activity 17.5 % 10.1016/j.ejmech.2020.112438
Mus musculus Mus musculus Activity 17.95 % 10.1016/j.bmcl.2016.09.034
Mus musculus Mus musculus Activity 18.63 None 10.1016/j.bmc.2021.116344
Mus musculus Mus musculus Activity 25.5 % 10.1016/j.bmc.2010.06.002
Mus musculus Mus musculus Activity 30.0 % 10.1021/jm901269y
Mus musculus Mus musculus Activity 31.0 None 10.1016/j.ejmech.2020.112066
Mus musculus Mus musculus Activity 31.1 % 10.1016/j.ejmech.2020.112066
Mus musculus Mus musculus Activity 31.4 % 10.1021/acs.jmedchem.1c00890
Mus musculus Mus musculus Activity 32.0 % 10.1016/j.ejmech.2021.113493
Mus musculus Mus musculus Activity 33.0 % 10.1021/acs.jmedchem.1c00880
Mus musculus Mus musculus Activity 35.0 % 10.1021/jm901269y
Mus musculus Mus musculus Activity 36.0 % 10.1016/j.ejmech.2020.112438
Mus musculus Mus musculus Activity 39.0 % 10.1016/j.bmc.2013.12.008
Mus musculus Mus musculus Activity 45.0 % 10.1016/j.bmc.2013.12.008
Mus musculus Mus musculus Activity 46.7 % 10.1039/C7MD00390K
Mus musculus Mus musculus Activity 56.0 % 10.1016/j.bmc.2013.12.008
Mus musculus Mus musculus Activity 57.4 % 10.1016/j.bmc.2014.12.041
Mus musculus Mus musculus Activity 59.0 % 10.1016/j.bmc.2013.12.008
Mus musculus Mus musculus Activity 62.0 % 10.1021/acs.jmedchem.1c00880
Mus musculus Mus musculus Activity 73.53 % 10.1016/j.bmcl.2020.127743
Mus musculus Mus musculus Activity 75.0 % 10.1016/j.bmc.2013.12.008
Mus musculus Mus musculus Activity 79.0 % 10.1016/j.ejmech.2020.112438
Mus musculus Mus musculus Activity nan None 10.1016/j.bmc.2013.12.008
Mus musculus Mus musculus Activity nan None 10.1016/j.ejmech.2011.11.003
Mus musculus Mus musculus ED50 0.07 umol.kg-1 10.1016/j.ejmech.2014.04.065
Mus musculus Mus musculus ED50 0.072 umol.kg-1 10.1016/j.ejmech.2014.04.065
Mus musculus Mus musculus ED50 0.156 umol.kg-1 10.1016/j.ejmech.2014.04.065
Mus musculus Mus musculus ED50 0.33 mg.kg-1 10.1016/s0960-894x(98)00627-1
Mus musculus Mus musculus ED50 71.0 mg.kg-1 10.1016/j.bmc.2016.06.026
Mus musculus Mus musculus ED50 71.0 mg.kg-1 10.1016/j.ejmech.2014.12.039
Mus musculus Mus musculus ED50 71.6 mg.kg-1 10.1016/j.ejmech.2016.05.066
Mus musculus Mus musculus ED50 72.0 mg.kg-1 10.1016/j.bmc.2016.03.032
Mus musculus Mus musculus ED50 74.1 mg.kg-1 10.1016/j.ejmech.2016.03.011
Mus musculus Mus musculus ED50 247.0 umol.kg-1 10.1016/j.bmc.2008.11.018
Mus musculus Mus musculus IC 652.1 mg kg-1 10.1016/j.ejmech.2015.07.036
Mus musculus Mus musculus Inhibition 8.6 % 10.1016/j.ejmech.2020.112438
Mus musculus Mus musculus Inhibition 13.43 % 10.1016/j.ejmech.2020.112662
Mus musculus Mus musculus Inhibition 24.1 % 10.1016/j.bmc.2010.06.002
Mus musculus Mus musculus Inhibition 28.2 % 10.1016/j.bmc.2021.116344
Mus musculus Mus musculus Inhibition 33.0 % 10.1021/acs.jmedchem.8b00922
Mus musculus Mus musculus Inhibition 35.0 % 10.1016/j.ejmech.2008.11.012
Mus musculus Mus musculus Inhibition 36.1 % 10.1016/j.bmc.2021.116344
Mus musculus Mus musculus Inhibition 42.0 % 10.1016/j.bmc.2013.04.031
Mus musculus Mus musculus Inhibition 46.1 % 10.1016/j.bmc.2008.11.018
Mus musculus Mus musculus Inhibition 46.3 % 10.1016/j.ejmech.2011.01.002
Mus musculus Mus musculus Inhibition 47.0 % 10.1016/j.ejmech.2016.11.026
Mus musculus Mus musculus Inhibition 47.9 % 10.1016/j.ejmech.2011.01.002
Mus musculus Mus musculus Inhibition 48.81 % 10.1016/j.bmcl.2022.129101
Mus musculus Mus musculus Inhibition 50.0 % 10.1016/j.bmc.2013.04.031
Mus musculus Mus musculus Inhibition 53.0 % 10.1016/j.ejmech.2015.07.036
Mus musculus Mus musculus Inhibition 56.0 % 10.1016/j.ejmech.2008.11.012
Mus musculus Mus musculus Inhibition 56.4 % 10.1016/j.bmc.2010.06.002
Mus musculus Mus musculus Inhibition 56.9 % 10.1016/j.bmc.2010.06.002
Mus musculus Mus musculus Inhibition 57.0 % 10.1016/j.bmc.2013.04.031
Mus musculus Mus musculus Inhibition 58.0 % 10.1016/j.bmc.2013.04.031
Mus musculus Mus musculus Inhibition 62.0 % 10.1021/acs.jmedchem.8b00922
Mus musculus Mus musculus Inhibition 64.9 % 10.1016/j.ejmech.2016.08.039
Mus musculus Mus musculus Inhibition 65.9 % 10.1016/j.ejmech.2019.111863
Mus musculus Mus musculus Inhibition 68.4 % 10.1016/j.bmc.2010.06.002
Mus musculus Mus musculus Inhibition 69.0 % 10.1016/j.bmc.2013.04.031
Mus musculus Mus musculus Inhibition 70.89 % 10.1016/j.ejmech.2014.05.012
Mus musculus Mus musculus Inhibition 77.0 % 10.1016/j.ejmech.2015.07.036
Mus musculus Mus musculus Inhibition 77.03 % 10.1016/j.bmcl.2016.12.008
Mus musculus Mus musculus Inhibition 80.0 % 10.1007/s00044-011-9606-4
Mus musculus Mus musculus Inhibition 100.0 % 10.1007/s00044-011-9606-4
Mus musculus Mus musculus Inhibition nan % 10.1016/j.bmcl.2016.09.034
Mus musculus Mus musculus Inhibition nan % 10.1016/j.ejmech.2011.11.003
Mus musculus Mus musculus Inhibition nan % 10.1016/j.ejmech.2015.07.036
Mus musculus Mus musculus LD50 250.0 mg.kg-1 10.1007/s00044-011-9606-4
Mus musculus Mus musculus LD50 9800.0 umol.kg-1 10.1016/j.ejmech.2014.04.065
Mus musculus Mus musculus MED 3.0 mg kg-1 10.1021/jm301370e
Mus musculus Mus musculus Survival 25.0 % 10.1016/j.ejmech.2016.06.017
Mus musculus Mus musculus Survival 82.0 day 10.1021/acs.jmedchem.1c00890
Mus musculus Mus musculus TGI 65.9 % 10.1021/acs.jmedchem.1c00890
Mus musculus Mus musculus TIME 0.001056 hr 10.1016/j.bmc.2010.06.002
Mus musculus Mus musculus TIME 0.001222 hr 10.1016/j.bmc.2010.06.002
Mus musculus Mus musculus TIME 0.001528 hr 10.1016/j.bmc.2010.06.002
Mus musculus Mus musculus TIME 0.001583 hr 10.1016/j.bmc.2010.06.002
Mus musculus Mus musculus UI 0.0 None 10.1016/j.ejmech.2008.11.012
Mus musculus Nitric oxide synthase, inducible IC50 nan None None
Mus musculus Nitric oxide synthase, inducible Inhibition 96.0 % 10.1016/j.bmc.2009.01.029
Mus musculus Nitric oxide synthase, inducible Ki nan None None
Mus musculus Prostaglandin G/H synthase (cyclooxygenase) Selectivity 93.0 None 10.1016/s0960-894x(00)00634-x
Mus musculus Prostaglandin G/H synthase (cyclooxygenase) Selectivity 93.0 None 10.1021/jm020545z
Mus musculus Prostaglandin G/H synthase (cyclooxygenase) SI 64.5 None 10.1021/jm049121q
Mus musculus RAW264.7 Activity 0.83 % 10.1016/j.ejmech.2021.113162
Mus musculus RAW264.7 Activity 33.9 % 10.1016/j.bmcl.2017.02.076
Mus musculus RAW264.7 Activity 80.0 % 10.1016/j.bmc.2021.116344
Mus musculus RAW264.7 Activity nan None 10.1016/j.bmcl.2017.10.058
Mus musculus RAW264.7 Activity nan None 10.1016/j.bmcl.2018.04.033
Mus musculus RAW264.7 IC50 17.0 ug.mL-1 10.1128/aac.00048-09
Mus musculus RAW264.7 IC50 100.0 nM 10.1016/j.bmc.2011.09.034
Mus musculus RAW264.7 IC50 1280.0 nM 10.1016/j.bmcl.2014.03.014
Mus musculus RAW264.7 IC50 1600.0 nM 10.1021/acs.jnatprod.5b00135
Mus musculus RAW264.7 IC50 1840.0 nM 10.1016/j.bmcl.2014.03.014
Mus musculus RAW264.7 IC50 2300.0 nM 10.1021/acs.jnatprod.1c00585
Mus musculus RAW264.7 IC50 7460.0 nM 10.1016/j.ejmech.2021.113457
Mus musculus RAW264.7 IC50 10690.0 nM 10.1016/j.ejmech.2021.113457
Mus musculus RAW264.7 IC50 11170.0 nM 10.1016/j.ejmech.2021.113457
Mus musculus RAW264.7 IC50 11730.0 nM 10.1016/j.ejmech.2021.113457
Mus musculus RAW264.7 IC50 19580.0 nM 10.1016/j.ejmech.2021.113457
Mus musculus RAW264.7 IC50 34300.0 nM 10.1016/j.ejmech.2021.113165
Mus musculus RAW264.7 IC50 11130000.0 nM 10.1016/j.bmc.2012.03.028
Mus musculus RAW264.7 IC50 12090000.0 nM 10.1016/j.bmc.2012.03.028
Mus musculus RAW264.7 Inhibition 14.8 % 10.1016/j.bmc.2021.116344
Mus musculus RAW264.7 Inhibition 16.5 % 10.1016/j.bmc.2021.116344
Mus musculus RAW264.7 Inhibition 19.0 % 10.1021/np4009877
Mus musculus RAW264.7 Inhibition 19.6 % 10.1016/j.bmc.2021.116344
Mus musculus RAW264.7 Inhibition 50.2 % 10.1016/j.bmc.2021.116344
Mus musculus RAW264.7 Inhibition 53.4 % 10.1016/j.bmc.2014.09.028
Mus musculus RAW264.7 Inhibition 59.2 % 10.1021/acs.jnatprod.5b00135
Mus musculus RAW264.7 Inhibition nan % 10.1016/j.ejmech.2019.05.004
Mus musculus RAW264.7 Inhibition nan % 10.1016/j.ejmech.2021.113162
Mycobacterium tuberculosis Carbonic anhydrase Ki 713.0 nM 10.1016/j.bmcl.2009.10.009
Mycobacterium tuberculosis Carbonic anhydrase Ki 713.0 nM 10.1021/jm300878g
Mycobacterium tuberculosis PROBABLE TRANSMEMBRANE CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) Ki 7760.0 nM 10.1021/jm300878g
Mycobacterium tuberculosis Uncharacterized protein Rv1284/MT1322 Ki 10350.0 nM 10.1021/jm300878g
Mycobacterium tuberculosis Uncharacterized protein Rv1284/MT1322 Ki 10350.0 nM 10.1021/jm9003126
Mycolicibacterium smegmatis Mycolicibacterium smegmatis MIC 100000.0 nM 10.1128/aac.00735-10
Oryctolagus cuniculus Angiotensin-converting enzyme IC50 nan None None
Oryctolagus cuniculus Angiotensin-converting enzyme Ki nan None None
Oryctolagus cuniculus Arachidonate 15-lipoxygenase IC50 nan None None
Oryctolagus cuniculus Arachidonate 15-lipoxygenase Inhibition 22.0 % 10.1016/j.bmc.2008.01.047
Oryctolagus cuniculus Arachidonate 15-lipoxygenase Ki nan None None
Oryctolagus cuniculus Oryctolagus cuniculus Delta IOP 2.35 mmHg 10.1021/jm030912m
Oryctolagus cuniculus Oryctolagus cuniculus Delta IOP 2.62 mmHg 10.1021/jm030912m
Oryctolagus cuniculus Oryctolagus cuniculus Delta IOP 2.97 mmHg 10.1021/jm030912m
Oryctolagus cuniculus Oryctolagus cuniculus Delta IOP 3.84 mmHg 10.1021/jm030912m
Oryctolagus cuniculus Oryctolagus cuniculus Delta IOP 4.15 mmHg 10.1021/jm030912m
Oryctolagus cuniculus Oryctolagus cuniculus Delta IOP 4.9 mmHg 10.1021/jm030912m
Oryctolagus cuniculus Oryctolagus cuniculus Delta IOP 5.87 mmHg 10.1021/jm030912m
Ovis aries Cyclooxygenase-1 Activity nan None 10.1021/np500198g
Ovis aries Cyclooxygenase-1 IC50 3.7 nM 10.1016/j.bmcl.2006.06.032
Ovis aries Cyclooxygenase-1 IC50 91.0 nM 10.1016/j.ejmech.2021.113682
Ovis aries Cyclooxygenase-1 IC50 210.0 nM 10.1016/j.bmc.2006.12.041
Ovis aries Cyclooxygenase-1 IC50 500.0 nM 10.1016/j.ejmech.2019.07.004
Ovis aries Cyclooxygenase-1 IC50 1000.0 nM 10.1016/j.bmc.2013.04.074
Ovis aries Cyclooxygenase-1 IC50 1000.0 nM 10.1016/j.bmcl.2014.02.074
Ovis aries Cyclooxygenase-1 IC50 3090.0 nM 10.1016/j.bmc.2018.07.024
Ovis aries Cyclooxygenase-1 IC50 4000.0 nM 10.1021/ml100232q
Ovis aries Cyclooxygenase-1 IC50 5460.0 nM 10.1016/j.ejmech.2020.112438
Ovis aries Cyclooxygenase-1 IC50 5640.0 nM 10.1016/j.ejmech.2016.12.030
Ovis aries Cyclooxygenase-1 IC50 6200.0 nM 10.1016/j.bmc.2018.01.007
Ovis aries Cyclooxygenase-1 IC50 6410.0 nM 10.1016/j.bmcl.2017.06.002
Ovis aries Cyclooxygenase-1 IC50 6700.0 nM 10.1016/j.bmc.2017.06.027
Ovis aries Cyclooxygenase-1 IC50 6700.0 nM 10.1016/j.bmcl.2015.11.105
Ovis aries Cyclooxygenase-1 IC50 6860.0 nM 10.1021/jm100398z
Ovis aries Cyclooxygenase-1 IC50 6900.0 nM 10.1016/j.bmcl.2015.10.047
Ovis aries Cyclooxygenase-1 IC50 7000.0 nM 10.1016/j.bmcl.2016.08.034
Ovis aries Cyclooxygenase-1 IC50 7100.0 nM 10.1016/j.bmc.2018.06.038
Ovis aries Cyclooxygenase-1 IC50 7320.0 nM 10.1016/j.ejmech.2016.11.006
Ovis aries Cyclooxygenase-1 IC50 7340.0 nM 10.1039/d2md00192f
Ovis aries Cyclooxygenase-1 IC50 7590.0 nM 10.1016/j.ejmech.2016.08.013
Ovis aries Cyclooxygenase-1 IC50 7600.0 nM 10.1016/j.bmcl.2016.04.046
Ovis aries Cyclooxygenase-1 IC50 7600.0 nM 10.1016/j.ejmech.2016.04.049
Ovis aries Cyclooxygenase-1 IC50 7700.0 nM 10.1016/j.bmc.2008.10.001
Ovis aries Cyclooxygenase-1 IC50 7700.0 nM 10.1016/j.bmc.2009.05.046
Ovis aries Cyclooxygenase-1 IC50 7700.0 nM 10.1016/j.bmcl.2008.10.009
Ovis aries Cyclooxygenase-1 IC50 7700.0 nM 10.1016/j.bmcl.2008.12.066
Ovis aries Cyclooxygenase-1 IC50 7700.0 nM 10.1016/j.bmcl.2010.01.014
Ovis aries Cyclooxygenase-1 IC50 7700.0 nM 10.1016/j.bmcl.2011.05.017
Ovis aries Cyclooxygenase-1 IC50 7700.0 nM 10.1016/j.bmcl.2011.08.053
Ovis aries Cyclooxygenase-1 IC50 7700.0 nM 10.1016/j.bmcl.2012.01.130
Ovis aries Cyclooxygenase-1 IC50 7700.0 nM 10.1016/j.bmcl.2012.10.131
Ovis aries Cyclooxygenase-1 IC50 7700.0 nM 10.1016/j.bmcl.2017.08.023
Ovis aries Cyclooxygenase-1 IC50 8100.0 nM 10.1016/j.bmc.2011.01.043
Ovis aries Cyclooxygenase-1 IC50 8222.0 nM 10.1016/j.bmc.2017.11.027
Ovis aries Cyclooxygenase-1 IC50 8320.0 nM 10.1016/j.bmcl.2009.10.069
Ovis aries Cyclooxygenase-1 IC50 9340.0 nM 10.1016/j.bmcl.2020.127173
Ovis aries Cyclooxygenase-1 IC50 9400.0 nM 10.1016/j.bmcl.2011.01.057
Ovis aries Cyclooxygenase-1 IC50 10000.0 nM 10.1016/j.bmcl.2012.01.093
Ovis aries Cyclooxygenase-1 IC50 10700.0 nM 10.1016/j.bmcl.2003.10.027
Ovis aries Cyclooxygenase-1 IC50 10700.0 nM 10.1016/j.bmcl.2004.01.053
Ovis aries Cyclooxygenase-1 IC50 13000.0 nM 10.1016/j.bmc.2007.09.038
Ovis aries Cyclooxygenase-1 IC50 14000.0 nM 10.1016/j.bmc.2014.03.043
Ovis aries Cyclooxygenase-1 IC50 14000.0 nM 10.1016/j.ejmech.2017.08.046
Ovis aries Cyclooxygenase-1 IC50 14700.0 nM 10.1016/j.bmc.2020.115403
Ovis aries Cyclooxygenase-1 IC50 14700.0 nM 10.1016/j.ejmech.2020.112439
Ovis aries Cyclooxygenase-1 IC50 14700.0 nM 10.1016/j.ejmech.2021.113457
Ovis aries Cyclooxygenase-1 IC50 14800.0 nM 10.1016/j.bmc.2017.08.039
Ovis aries Cyclooxygenase-1 IC50 14800.0 nM 10.1016/j.ejmech.2017.12.065
Ovis aries Cyclooxygenase-1 IC50 14800.0 nM 10.1016/j.ejmech.2019.02.012
Ovis aries Cyclooxygenase-1 IC50 14800.0 nM 10.1016/j.ejmech.2019.02.034
Ovis aries Cyclooxygenase-1 IC50 14800.0 nM 10.1016/j.ejmech.2019.03.042
Ovis aries Cyclooxygenase-1 IC50 15000.0 nM 10.1016/j.bmc.2012.02.021
Ovis aries Cyclooxygenase-1 IC50 15000.0 nM 10.1016/j.bmc.2019.115246
Ovis aries Cyclooxygenase-1 IC50 15000.0 nM 10.1016/j.bmcl.2012.08.082
Ovis aries Cyclooxygenase-1 IC50 15000.0 nM 10.1016/j.bmcl.2013.11.080
Ovis aries Cyclooxygenase-1 IC50 15000.0 nM 10.1016/j.bmcl.2016.02.029
Ovis aries Cyclooxygenase-1 IC50 15000.0 nM 10.1016/j.bmcl.2018.01.043
Ovis aries Cyclooxygenase-1 IC50 15000.0 nM 10.1016/j.ejmech.2014.03.003
Ovis aries Cyclooxygenase-1 IC50 15000.0 nM 10.1016/j.ejmech.2015.04.044
Ovis aries Cyclooxygenase-1 IC50 15000.0 nM 10.1021/acs.jmedchem.1c00880
Ovis aries Cyclooxygenase-1 IC50 15000.0 nM 10.1021/acs.jmedchem.6b00134
Ovis aries Cyclooxygenase-1 IC50 15000.0 nM 10.1021/acs.jmedchem.8b00922
Ovis aries Cyclooxygenase-1 IC50 15000.0 nM 10.1021/acs.jmedchem.9b00823
Ovis aries Cyclooxygenase-1 IC50 15100.0 nM 10.1016/j.ejmech.2019.111693
Ovis aries Cyclooxygenase-1 IC50 15130.0 nM 10.1016/j.bmc.2016.09.023
Ovis aries Cyclooxygenase-1 IC50 15135.61 nM 10.1021/jm020089e
Ovis aries Cyclooxygenase-1 IC50 15330.0 nM 10.1021/jm020563g
Ovis aries Cyclooxygenase-1 IC50 16200.0 nM 10.1016/j.bmc.2016.11.037
Ovis aries Cyclooxygenase-1 IC50 16520.0 nM 10.1016/j.bmc.2021.116344
Ovis aries Cyclooxygenase-1 IC50 18140.0 nM 10.1016/j.bmcl.2017.02.076
Ovis aries Cyclooxygenase-1 IC50 19030.0 nM 10.1016/j.bmc.2007.06.030
Ovis aries Cyclooxygenase-1 IC50 22900.0 nM 10.1016/j.bmcl.2013.11.015
Ovis aries Cyclooxygenase-1 IC50 22900.0 nM 10.1016/s0960-894x(03)00391-3
Ovis aries Cyclooxygenase-1 IC50 22900.0 nM 10.1021/jm0302391
Ovis aries Cyclooxygenase-1 IC50 23000.0 nM 10.1007/s00044-012-0244-2
Ovis aries Cyclooxygenase-1 IC50 23000.0 nM 10.1016/j.bmcl.2004.01.075
Ovis aries Cyclooxygenase-1 IC50 24300.0 nM 10.1007/s00044-011-9709-y
Ovis aries Cyclooxygenase-1 IC50 24300.0 nM 10.1007/s00044-011-9710-5
Ovis aries Cyclooxygenase-1 IC50 24300.0 nM 10.1007/s00044-012-0387-1
Ovis aries Cyclooxygenase-1 IC50 24300.0 nM 10.1016/j.bmc.2009.05.084
Ovis aries Cyclooxygenase-1 IC50 24300.0 nM 10.1016/j.bmc.2009.06.056
Ovis aries Cyclooxygenase-1 IC50 24300.0 nM 10.1016/j.bmc.2009.12.060
Ovis aries Cyclooxygenase-1 IC50 24300.0 nM 10.1016/j.bmc.2013.12.002
Ovis aries Cyclooxygenase-1 IC50 24300.0 nM 10.1016/j.bmc.2020.115960
Ovis aries Cyclooxygenase-1 IC50 24300.0 nM 10.1016/j.bmcl.2008.01.021
Ovis aries Cyclooxygenase-1 IC50 24300.0 nM 10.1016/j.bmcl.2009.04.125
Ovis aries Cyclooxygenase-1 IC50 24300.0 nM 10.1016/j.ejmech.2010.05.058
Ovis aries Cyclooxygenase-1 IC50 25000.0 nM 10.1016/j.ejmech.2018.09.007
Ovis aries Cyclooxygenase-1 IC50 26610.0 nM 10.1016/j.bmcl.2006.06.036
Ovis aries Cyclooxygenase-1 IC50 27250.0 nM 10.1021/ml400500e
Ovis aries Cyclooxygenase-1 IC50 30000.0 nM 10.1016/j.bmc.2013.05.029
Ovis aries Cyclooxygenase-1 IC50 30000.0 nM 10.1016/j.bmc.2014.02.042
Ovis aries Cyclooxygenase-1 IC50 30000.0 nM 10.1016/j.ejmech.2014.04.033
Ovis aries Cyclooxygenase-1 IC50 30000.0 nM 10.1021/ml500156v
Ovis aries Cyclooxygenase-1 IC50 32000.0 nM 10.1016/j.bmcl.2014.08.062
Ovis aries Cyclooxygenase-1 IC50 33100.0 nM 10.1016/j.bmc.2007.07.021
Ovis aries Cyclooxygenase-1 IC50 33100.0 nM 10.1016/j.bmc.2007.11.003
Ovis aries Cyclooxygenase-1 IC50 33100.0 nM 10.1016/j.bmc.2007.12.006
Ovis aries Cyclooxygenase-1 IC50 33100.0 nM 10.1016/j.bmcl.2004.07.027
Ovis aries Cyclooxygenase-1 IC50 33100.0 nM 10.1016/j.bmcl.2004.10.050
Ovis aries Cyclooxygenase-1 IC50 33100.0 nM 10.1016/j.ejmech.2009.04.009
Ovis aries Cyclooxygenase-1 IC50 33100.0 nM 10.1021/jm049523y
Ovis aries Cyclooxygenase-1 IC50 33100.0 nM 10.1021/jm049939b
Ovis aries Cyclooxygenase-1 IC50 33100.0 nM 10.1021/jm0510474
Ovis aries Cyclooxygenase-1 IC50 33100.0 nM 10.1021/jm1001327
Ovis aries Cyclooxygenase-1 IC50 34500.0 nM 10.1016/j.ejmech.2011.10.029
Ovis aries Cyclooxygenase-1 IC50 48000.0 nM 10.1016/j.bmc.2022.116633
Ovis aries Cyclooxygenase-1 IC50 50000.0 nM 10.1016/j.bmc.2011.04.027
Ovis aries Cyclooxygenase-1 IC50 50000.0 nM 10.1016/j.bmc.2012.03.044
Ovis aries Cyclooxygenase-1 IC50 50000.0 nM 10.1016/j.ejmech.2014.01.063
Ovis aries Cyclooxygenase-1 IC50 50000.0 nM 10.1016/j.ejmech.2014.02.033
Ovis aries Cyclooxygenase-1 IC50 50000.0 nM 10.1016/j.ejmech.2014.08.048
Ovis aries Cyclooxygenase-1 IC50 50000.0 nM 10.1039/C6MD00367B
Ovis aries Cyclooxygenase-1 IC50 72520.0 nM 10.1016/j.ejmech.2019.111863
Ovis aries Cyclooxygenase-1 IC50 78400.0 nM 10.1016/j.bmcl.2015.03.017
Ovis aries Cyclooxygenase-1 IC50 78400.0 nM 10.1016/j.bmcl.2015.08.034
Ovis aries Cyclooxygenase-1 IC50 81700.0 nM 10.1016/j.bmcl.2015.04.085
Ovis aries Cyclooxygenase-1 IC50 100000.0 nM 10.1016/j.bmc.2008.01.047
Ovis aries Cyclooxygenase-1 IC50 100000.0 nM 10.1016/j.bmc.2015.10.007
Ovis aries Cyclooxygenase-1 IC50 100000.0 nM 10.1016/j.bmc.2016.03.032
Ovis aries Cyclooxygenase-1 IC50 100000.0 nM 10.1016/j.bmc.2016.06.026
Ovis aries Cyclooxygenase-1 IC50 100000.0 nM 10.1016/j.bmcl.2013.02.107
Ovis aries Cyclooxygenase-1 IC50 100000.0 nM 10.1016/j.bmcl.2015.05.059
Ovis aries Cyclooxygenase-1 IC50 100000.0 nM 10.1016/j.ejmech.2011.02.013
Ovis aries Cyclooxygenase-1 IC50 100000.0 nM 10.1016/j.ejmech.2014.04.045
Ovis aries Cyclooxygenase-1 IC50 100000.0 nM 10.1016/j.ejmech.2014.12.039
Ovis aries Cyclooxygenase-1 IC50 100000.0 nM 10.1016/j.ejmech.2016.03.011
Ovis aries Cyclooxygenase-1 IC50 100000.0 nM 10.1016/j.ejmech.2016.05.066
Ovis aries Cyclooxygenase-1 IC50 100000.0 nM 10.1016/j.ejmech.2019.07.016
Ovis aries Cyclooxygenase-1 IC50 100000.0 nM 10.1021/acs.jnatprod.2c01153
Ovis aries Cyclooxygenase-1 IC50 100000.0 nM 10.1021/acsmedchemlett.1c00065
Ovis aries Cyclooxygenase-1 IC50 115000.0 nM 10.1016/j.bmc.2012.04.022
Ovis aries Cyclooxygenase-1 IC50 115900.0 nM 10.1016/j.bmcl.2010.06.022
Ovis aries Cyclooxygenase-1 IC50 115900.0 nM 10.1016/j.bmcl.2010.06.155
Ovis aries Cyclooxygenase-1 IC50 117000.0 nM 10.1016/j.bmc.2014.02.032
Ovis aries Cyclooxygenase-1 IC50 nan None 10.1016/j.bmcl.2014.08.050
Ovis aries Cyclooxygenase-1 IC50 nan None 10.1021/acs.jnatprod.7b00322
Ovis aries Cyclooxygenase-1 Inhibition 0.0 % 10.1016/j.bmcl.2004.01.053
Ovis aries Cyclooxygenase-1 Inhibition 0.0 % 10.1021/jm020563g
Ovis aries Cyclooxygenase-1 Inhibition 0.3 % 10.1016/j.bmc.2010.01.021
Ovis aries Cyclooxygenase-1 Inhibition 0.3 % 10.1016/j.bmc.2010.06.018
Ovis aries Cyclooxygenase-1 Inhibition 0.45 % 10.1016/j.bmc.2015.07.070
Ovis aries Cyclooxygenase-1 Inhibition 2.0 % 10.1007/s00044-011-9747-5
Ovis aries Cyclooxygenase-1 Inhibition 2.0 % 10.1016/j.bmcl.2018.01.043
Ovis aries Cyclooxygenase-1 Inhibition 2.0 % 10.1016/j.ejmech.2014.04.065
Ovis aries Cyclooxygenase-1 Inhibition 2.8 % 10.1016/j.bmc.2007.09.038
Ovis aries Cyclooxygenase-1 Inhibition 2.8 % 10.1016/j.bmc.2014.03.043
Ovis aries Cyclooxygenase-1 Inhibition 2.8 % 10.1016/j.bmcl.2015.01.041
Ovis aries Cyclooxygenase-1 Inhibition 3.0 % 10.1016/j.bmc.2011.06.019
Ovis aries Cyclooxygenase-1 Inhibition 3.0 % 10.1016/j.bmc.2012.09.069
Ovis aries Cyclooxygenase-1 Inhibition 13.0 % 10.1016/j.bmc.2013.05.029
Ovis aries Cyclooxygenase-1 Inhibition 13.01 % 10.1016/j.bmcl.2014.08.050
Ovis aries Cyclooxygenase-1 Inhibition 13.1 % 10.1021/np300899w
Ovis aries Cyclooxygenase-1 Inhibition 20.0 % 10.1016/j.bmc.2022.116633
Ovis aries Cyclooxygenase-1 Inhibition 21.4 % 10.1016/j.bmc.2022.116633
Ovis aries Cyclooxygenase-1 Inhibition 21.7 % 10.1016/j.ejmech.2014.07.023
Ovis aries Cyclooxygenase-1 Inhibition 26.68 % 10.1021/ml400500e
Ovis aries Cyclooxygenase-1 Inhibition 27.0 % 10.1016/j.bmc.2021.116344
Ovis aries Cyclooxygenase-1 Inhibition 36.0 % 10.1016/j.bmc.2021.116344
Ovis aries Cyclooxygenase-1 Inhibition 40.0 % 10.1016/j.ejmech.2013.12.023
Ovis aries Cyclooxygenase-1 Inhibition 41.0 % 10.1021/jm2001376
Ovis aries Cyclooxygenase-1 Inhibition 48.0 % 10.1016/j.bmc.2021.116344
Ovis aries Cyclooxygenase-1 Inhibition 59.0 % 10.1016/j.bmc.2021.116344
Ovis aries Cyclooxygenase-1 Inhibition 68.87 % 10.1016/j.bmcl.2017.02.076
Ovis aries Cyclooxygenase-1 Inhibition 70.0 % 10.1016/j.bmc.2009.10.025
Ovis aries Cyclooxygenase-1 Inhibition 77.0 % 10.1021/jm401557w
Ovis aries Cyclooxygenase-1 Inhibition 77.6 % 10.1016/j.bmcl.2005.02.039
Ovis aries Cyclooxygenase-1 Inhibition nan % 10.1016/j.ejmech.2013.10.083
Ovis aries Cyclooxygenase-1 Inhibition nan % 10.1021/acs.jmedchem.0c01120
Ovis aries Cyclooxygenase-1 Ki 3.54 None 10.1021/jm020089e
Ovis aries Cyclooxygenase-1 Ratio 404.0 None 10.1016/s0960-894x(03)00391-3
Ovis aries Cyclooxygenase-2 IC50 40.0 nM 10.1016/j.bmc.2007.09.038
Ovis aries Cyclooxygenase-2 IC50 40.0 nM 10.1016/j.bmc.2014.03.043
Ovis aries Cyclooxygenase-2 IC50 40.0 nM 10.1016/j.bmc.2016.09.023
Ovis aries Cyclooxygenase-2 IC50 40.0 nM 10.1039/d2md00076h
Ovis aries Cyclooxygenase-2 IC50 50.0 nM 10.1016/j.bmc.2011.01.043
Ovis aries Cyclooxygenase-2 IC50 50.0 nM 10.1016/j.ejmech.2019.02.012
Ovis aries Cyclooxygenase-2 IC50 50.0 nM 10.1016/j.ejmech.2019.03.042
Ovis aries Cyclooxygenase-2 IC50 50.7 nM 10.1016/j.bmc.2018.06.038
Ovis aries Cyclooxygenase-2 IC50 56.7 nM 10.1016/s0960-894x(03)00391-3
Ovis aries Cyclooxygenase-2 IC50 57.0 nM 10.1007/s00044-012-0244-2
Ovis aries Cyclooxygenase-2 IC50 57.0 nM 10.1016/j.bmcl.2004.01.075
Ovis aries Cyclooxygenase-2 IC50 60.0 nM 10.1007/s00044-011-9709-y
Ovis aries Cyclooxygenase-2 IC50 60.0 nM 10.1007/s00044-011-9710-5
Ovis aries Cyclooxygenase-2 IC50 60.0 nM 10.1007/s00044-012-0387-1
Ovis aries Cyclooxygenase-2 IC50 60.0 nM 10.1016/j.bmc.2009.05.084
Ovis aries Cyclooxygenase-2 IC50 60.0 nM 10.1016/j.bmc.2009.06.056
Ovis aries Cyclooxygenase-2 IC50 60.0 nM 10.1016/j.bmc.2009.12.060
Ovis aries Cyclooxygenase-2 IC50 60.0 nM 10.1016/j.bmc.2013.12.002
Ovis aries Cyclooxygenase-2 IC50 60.0 nM 10.1016/j.bmc.2020.115960
Ovis aries Cyclooxygenase-2 IC50 60.0 nM 10.1016/j.bmcl.2008.01.021
Ovis aries Cyclooxygenase-2 IC50 60.0 nM 10.1016/j.bmcl.2009.04.125
Ovis aries Cyclooxygenase-2 IC50 60.0 nM 10.1016/j.ejmech.2010.05.058
Ovis aries Cyclooxygenase-2 IC50 70.0 nM 10.1016/j.bmc.2007.07.021
Ovis aries Cyclooxygenase-2 IC50 70.0 nM 10.1016/j.bmc.2007.11.003
Ovis aries Cyclooxygenase-2 IC50 70.0 nM 10.1016/j.bmc.2007.12.006
Ovis aries Cyclooxygenase-2 IC50 70.0 nM 10.1016/j.bmc.2008.10.001
Ovis aries Cyclooxygenase-2 IC50 70.0 nM 10.1016/j.bmcl.2004.07.027
Ovis aries Cyclooxygenase-2 IC50 70.0 nM 10.1016/j.bmcl.2004.10.050
Ovis aries Cyclooxygenase-2 IC50 70.0 nM 10.1016/j.bmcl.2008.10.009
Ovis aries Cyclooxygenase-2 IC50 70.0 nM 10.1016/j.bmcl.2011.08.053
Ovis aries Cyclooxygenase-2 IC50 70.0 nM 10.1016/j.ejmech.2009.04.009
Ovis aries Cyclooxygenase-2 IC50 70.0 nM 10.1021/jm049523y
Ovis aries Cyclooxygenase-2 IC50 70.0 nM 10.1021/jm049939b
Ovis aries Cyclooxygenase-2 IC50 70.0 nM 10.1021/jm0510474
Ovis aries Cyclooxygenase-2 IC50 70.0 nM 10.1021/jm1001327
Ovis aries Cyclooxygenase-2 IC50 100.0 nM 10.1016/j.bmcl.2020.127173
Ovis aries Cyclooxygenase-2 IC50 100.0 nM 10.1021/jm100398z
Ovis aries Cyclooxygenase-2 IC50 100.0 nM 10.1039/C6MD00569A
Ovis aries Cyclooxygenase-2 IC50 110.0 nM 10.1016/j.ejmech.2018.09.007
Ovis aries Cyclooxygenase-2 IC50 113.0 nM 10.1016/j.bmcl.2009.10.069
Ovis aries Cyclooxygenase-2 IC50 150.0 nM 10.1016/j.bmc.2013.05.029
Ovis aries Cyclooxygenase-2 IC50 150.0 nM 10.1016/j.bmcl.2014.08.050
Ovis aries Cyclooxygenase-2 IC50 150.0 nM 10.1016/j.ejmech.2014.04.033
Ovis aries Cyclooxygenase-2 IC50 180.0 nM 10.1039/C6MD00367B
Ovis aries Cyclooxygenase-2 IC50 220.0 nM 10.1016/j.bmc.2014.02.042
Ovis aries Cyclooxygenase-2 IC50 260.0 nM 10.1016/j.bmcl.2013.02.107
Ovis aries Cyclooxygenase-2 IC50 260.0 nM 10.1016/j.ejmech.2014.12.039
Ovis aries Cyclooxygenase-2 IC50 280.0 nM 10.1016/j.bmc.2012.03.044
Ovis aries Cyclooxygenase-2 IC50 280.0 nM 10.1016/j.ejmech.2013.12.023
Ovis aries Cyclooxygenase-2 IC50 280.0 nM 10.1016/j.ejmech.2014.01.063
Ovis aries Cyclooxygenase-2 IC50 280.0 nM 10.1016/j.ejmech.2014.08.048
Ovis aries Cyclooxygenase-2 IC50 300.0 nM 10.1016/j.bmc.2011.04.027
Ovis aries Cyclooxygenase-2 IC50 300.0 nM 10.1016/j.bmc.2016.03.032
Ovis aries Cyclooxygenase-2 IC50 300.0 nM 10.1016/j.bmc.2016.06.026
Ovis aries Cyclooxygenase-2 IC50 300.0 nM 10.1016/j.bmcl.2014.08.062
Ovis aries Cyclooxygenase-2 IC50 300.0 nM 10.1016/j.ejmech.2011.02.013
Ovis aries Cyclooxygenase-2 IC50 300.0 nM 10.1016/j.ejmech.2016.03.011
Ovis aries Cyclooxygenase-2 IC50 330.0 nM 10.1016/j.ejmech.2016.05.066
Ovis aries Cyclooxygenase-2 IC50 360.0 nM 10.1016/j.ejmech.2011.08.015
Ovis aries Cyclooxygenase-2 IC50 440.0 nM 10.1016/j.bmcl.2006.06.036
Ovis aries Cyclooxygenase-2 IC50 540.0 nM 10.1016/j.ejmech.2018.11.027
Ovis aries Cyclooxygenase-2 IC50 560.0 nM 10.1016/j.bmc.2015.10.007
Ovis aries Cyclooxygenase-2 IC50 660.0 nM 10.1016/j.bmcl.2017.06.002
Ovis aries Cyclooxygenase-2 IC50 890.0 nM 10.1039/d1md00280e
Ovis aries Cyclooxygenase-2 IC50 1110.0 nM 10.1039/d2md00192f
Ovis aries Cyclooxygenase-2 IC50 1540.0 nM 10.1016/j.bmcl.2016.04.046
Ovis aries Cyclooxygenase-2 IC50 1540.0 nM 10.1016/j.ejmech.2016.04.049
Ovis aries Cyclooxygenase-2 IC50 1540.0 nM 10.1016/j.ejmech.2016.08.013
Ovis aries Cyclooxygenase-2 IC50 1710.0 nM 10.1016/j.bmc.2008.01.047
Ovis aries Cyclooxygenase-2 IC50 2050.0 nM 10.1016/j.bmcl.2005.02.039
Ovis aries Cyclooxygenase-2 Inhibition 49.23 % 10.1016/j.ejmech.2013.10.083
Ovis aries Cyclooxygenase-2 Inhibition 61.0 % 10.1016/j.bmcl.2018.01.043
Ovis aries Cyclooxygenase-2 Inhibition 61.0 % 10.1016/j.ejmech.2014.04.065
Ovis aries Cyclooxygenase-2 Inhibition 87.0 % 10.1016/j.ejmech.2013.12.023
Ovis aries Cyclooxygenase-2 Inhibition 94.0 % 10.1016/j.bmc.2011.06.019
Ovis aries Cyclooxygenase-2 Inhibition 94.0 % 10.1016/j.bmc.2012.09.069
Ovis aries Cyclooxygenase-2 Inhibition 95.3 % 10.1007/s00044-011-9747-5
Ovis aries Cyclooxygenase-2 Inhibition 95.57 % 10.1016/j.bmcl.2014.08.050
Ovis aries Cyclooxygenase-2 Inhibition 95.6 % 10.1016/j.bmc.2013.05.029
Ovis aries Cyclooxygenase-2 Inhibition 95.6 % 10.1021/np300899w
Ovis aries Cyclooxygenase-2 Inhibition 97.94 % 10.1016/j.bmc.2014.03.043
Ovis aries Cyclooxygenase-2 Inhibition 100.0 % 10.1016/j.bmc.2007.09.038
Ovis aries Cyclooxygenase-2 Inhibition nan % 10.1016/j.ejmech.2012.09.005
Ovis aries Cyclooxygenase-2 Inhibition nan % 10.1021/acs.jmedchem.0c01120
Ovis aries Cytochrome c oxidase subunit 1 IC50 6500.0 nM 10.1016/j.bmc.2019.07.050
Ovis aries Cytochrome c oxidase subunit 1 IC50 24300.0 nM 10.1016/j.bmc.2010.06.094
Ovis aries Cytochrome c oxidase subunit 1 IC50 27250.0 nM 10.1016/j.ejmech.2019.111601
Ovis aries Cytochrome c oxidase subunit 1 Inhibition 26.68 % 10.1016/j.ejmech.2019.111601
Ovis aries Cytochrome c oxidase subunit 2 IC50 42.6 nM 10.1016/j.ejmech.2021.113493
Ovis aries Cytochrome c oxidase subunit 2 IC50 60.0 nM 10.1016/j.bmc.2010.06.094
Ovis aries Cytochrome c oxidase subunit 2 IC50 90.0 nM 10.1016/j.ejmech.2021.113493
Ovis aries Cytochrome c oxidase subunit 2 IC50 160.0 nM 10.1016/j.ejmech.2021.113493
Ovis aries Prostaglandin G/H synthase (cyclooxygenase) Ratio IC50 474.0 None 10.1021/jm0510474
Ovis aries Prostaglandin G/H synthase (cyclooxygenase) Selectivity index 60.48 None 10.1016/j.bmcl.2006.06.036
Ovis aries Prostaglandin G/H synthase (cyclooxygenase) Selectivity index 401.0 None 10.1021/jm0302391
Ovis aries Prostaglandin G/H synthase (cyclooxygenase) Selectivity index 472.0 None 10.1016/j.bmcl.2004.07.027
Ovis aries Prostaglandin G/H synthase (cyclooxygenase) SI 472.0 None 10.1016/j.bmcl.2004.10.050
Ovis aries Prostaglandin G/H synthase (cyclooxygenase) SI 472.0 None 10.1021/jm049523y
Ovis aries Prostaglandin G/H synthase (cyclooxygenase) SI 474.0 None 10.1021/jm049939b
Plasmodium falciparum Plasmodium falciparum Potency 5358.2 nM None
Plasmodium falciparum Plasmodium falciparum Potency 5858.4 nM None
Plasmodium falciparum Plasmodium falciparum Potency 11689.1 nM None
Plasmodium falciparum Plasmodium falciparum Potency 15101.4 nM None
Pseudomonas aeruginosa Pseudomonas aeruginosa Inhibition 8.62 % 10.6019/CHEMBL4513141
Rattus norvegicus Aldose reductase IC50 nan None None
Rattus norvegicus Aldose reductase Ki nan None None
Rattus norvegicus Alpha-1a adrenergic receptor IC50 nan None None
Rattus norvegicus Alpha-1a adrenergic receptor Ki nan None None
Rattus norvegicus Alpha-1b adrenergic receptor IC50 nan None None
Rattus norvegicus Alpha-1b adrenergic receptor Ki nan None None
Rattus norvegicus Androgen Receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Rattus norvegicus Androgen Receptor IC50 nan None None
Rattus norvegicus Androgen Receptor Ki nan None None
Rattus norvegicus C6 IC50 40000.0 nM 10.1016/j.ejmech.2021.113564
Rattus norvegicus Cyclooxygenase IC50 132.0 nM 10.1016/j.ejmech.2017.09.056
Rattus norvegicus Cyclooxygenase Selectivity 12.9 None 10.1016/s0960-894x(01)00534-0
Rattus norvegicus Cyclooxygenase-1 AC50 28000.1 nM 10.1038/s41467-023-40064-9
Rattus norvegicus Cyclooxygenase-1 IC50 14200.0 nM 10.1016/s0960-894x(01)00534-0
Rattus norvegicus Cyclooxygenase-1 IC50 15000.0 nM 10.1016/j.bmcl.2014.03.087
Rattus norvegicus Cyclooxygenase-1 IC50 30210.0 nM 10.1016/j.bmc.2017.07.038
Rattus norvegicus Cyclooxygenase-2 ED50 3.7 mg.kg-1 10.1016/j.bmcl.2004.07.089
Rattus norvegicus Cyclooxygenase-2 IC50 71.0 nM 10.1016/j.bmc.2017.07.038
Rattus norvegicus Cyclooxygenase-2 IC50 140.0 nM 10.1016/j.ejmech.2015.11.013
Rattus norvegicus Cyclooxygenase-2 IC50 1100.0 nM 10.1016/s0960-894x(01)00534-0
Rattus norvegicus Cyclooxygenase-2 ID50 10.8 mg.kg-1 10.1021/jm049523y
Rattus norvegicus Cyclooxygenase-2 ID50 10.8 mg.kg-1 10.1021/jm049939b
Rattus norvegicus Cyclooxygenase-2 Inhibition 71.9 % 10.1016/j.bmcl.2005.02.039
Rattus norvegicus Cyclooxygenase-2 Inhibition 80.0 % 10.1021/jm049939b
Rattus norvegicus Cyclooxygenase-2 Inhibition nan % 10.1016/j.ejmech.2011.10.018
Rattus norvegicus GABA receptor alpha-1 subunit AC50 10000.0 nM 10.1038/s41467-023-40064-9
Rattus norvegicus Glutamate (NMDA) receptor subunit zeta 1 AC50 10000.0 nM 10.1038/s41467-023-40064-9
Rattus norvegicus Glycine receptor IC50 nan None None
Rattus norvegicus Glycine receptor Ki nan None None
Rattus norvegicus Insulin receptor IC50 nan None None
Rattus norvegicus Insulin receptor Ki nan None None
Rattus norvegicus Nitric-oxide synthase, brain IC50 nan None None
Rattus norvegicus Nitric-oxide synthase, brain Ki nan None None
Rattus norvegicus Nuclear receptor subfamily 1 group I member 2 Potency 56234.1 nM None
Rattus norvegicus Peripheral myelin protein 22 Potency 36125.4 nM None
Rattus norvegicus Plasma Cp 0.62 ug ml-1 10.1016/j.ejmech.2013.12.033
Rattus norvegicus Plasma Cp 1.0 uM 10.1021/jm300576q
Rattus norvegicus Plasma Cp 1.13 ug ml-1 10.1016/j.ejmech.2013.12.033
Rattus norvegicus Plasma Cp 2.68 ug ml-1 10.1016/j.ejmech.2013.12.033
Rattus norvegicus Rattus norvegicus Activity 0.0 % 10.1007/s00044-009-9203-y
Rattus norvegicus Rattus norvegicus Activity 0.0 % 10.1016/j.bmc.2008.04.007
Rattus norvegicus Rattus norvegicus Activity 0.0 % 10.1016/j.bmc.2010.01.021
Rattus norvegicus Rattus norvegicus Activity 0.0 % 10.1016/j.bmc.2010.06.018
Rattus norvegicus Rattus norvegicus Activity 0.0 % 10.1016/j.ejmech.2010.10.001
Rattus norvegicus Rattus norvegicus Activity 0.0 % 10.1021/jm070821f
Rattus norvegicus Rattus norvegicus Activity 0.24 mm 10.1016/j.ejmech.2019.03.042
Rattus norvegicus Rattus norvegicus Activity 0.41 mm 10.1016/j.ejmech.2019.03.042
Rattus norvegicus Rattus norvegicus Activity 0.42 mm 10.1007/s00044-009-9203-y
Rattus norvegicus Rattus norvegicus Activity 0.44 mm 10.1016/j.ejmech.2019.03.042
Rattus norvegicus Rattus norvegicus Activity 0.45 mm 10.1007/s00044-009-9203-y
Rattus norvegicus Rattus norvegicus Activity 0.46 mm 10.1016/j.ejmech.2019.03.042
Rattus norvegicus Rattus norvegicus Activity 0.5 mm 10.1007/s00044-009-9203-y
Rattus norvegicus Rattus norvegicus Activity 0.81 ug 10.1016/j.ejmech.2014.05.012
Rattus norvegicus Rattus norvegicus Activity 1.16 ml 10.1016/j.ejmech.2019.111601
Rattus norvegicus Rattus norvegicus Activity 1.23 ml 10.1016/j.ejmech.2019.111601
Rattus norvegicus Rattus norvegicus Activity 1.3 ml 10.1016/j.ejmech.2019.111601
Rattus norvegicus Rattus norvegicus Activity 1.33 % 10.1021/jm901269y
Rattus norvegicus Rattus norvegicus Activity 1.33 ml 10.1016/j.bmc.2008.07.058
Rattus norvegicus Rattus norvegicus Activity 1.34 ml 10.1016/j.ejmech.2019.111601
Rattus norvegicus Rattus norvegicus Activity 1.36 ml 10.1016/j.ejmech.2019.111601
Rattus norvegicus Rattus norvegicus Activity 1.36 ml 10.1021/jm200715n
Rattus norvegicus Rattus norvegicus Activity 1.38 ml 10.1016/j.ejmech.2019.111601
Rattus norvegicus Rattus norvegicus Activity 1.45 ml 10.1021/jm301370e
Rattus norvegicus Rattus norvegicus Activity 1.52 mm 10.1016/j.ejmech.2020.112066
Rattus norvegicus Rattus norvegicus Activity 1.56 ml 10.1016/j.ejmech.2022.114615
Rattus norvegicus Rattus norvegicus Activity 2.08 mm 10.1016/j.ejmech.2020.112066
Rattus norvegicus Rattus norvegicus Activity 2.11 % 10.1016/j.ejmech.2017.09.056
Rattus norvegicus Rattus norvegicus Activity 2.28 mm 10.1016/j.ejmech.2020.112662
Rattus norvegicus Rattus norvegicus Activity 2.35 ml 10.1021/jm301370e
Rattus norvegicus Rattus norvegicus Activity 2.52 mm 10.1016/j.ejmech.2020.112066
Rattus norvegicus Rattus norvegicus Activity 2.9 pg/ml 10.1016/j.ejmech.2014.05.012
Rattus norvegicus Rattus norvegicus Activity 2.94 mm 10.1016/j.ejmech.2020.112662
Rattus norvegicus Rattus norvegicus Activity 3.0 % 10.1021/jm070821f
Rattus norvegicus Rattus norvegicus Activity 3.08 mm 10.1016/j.ejmech.2020.112662
Rattus norvegicus Rattus norvegicus Activity 3.22 mm 10.1007/s00044-012-9975-3
Rattus norvegicus Rattus norvegicus Activity 3.35 pg/ml 10.1016/j.ejmech.2014.05.012
Rattus norvegicus Rattus norvegicus Activity 3.37 mm 10.1007/s00044-012-9975-3
Rattus norvegicus Rattus norvegicus Activity 3.48 mm 10.1016/j.ejmech.2019.03.036
Rattus norvegicus Rattus norvegicus Activity 3.75 mm 10.1007/s00044-012-9975-3
Rattus norvegicus Rattus norvegicus Activity 3.78 mm 10.1016/j.ejmech.2019.03.036
Rattus norvegicus Rattus norvegicus Activity 3.83 mm 10.1016/j.ejmech.2019.03.036
Rattus norvegicus Rattus norvegicus Activity 3.87 mm 10.1007/s00044-012-9975-3
Rattus norvegicus Rattus norvegicus Activity 3.88 mm 10.1016/j.ejmech.2019.03.036
Rattus norvegicus Rattus norvegicus Activity 3.93 mm 10.1016/j.ejmech.2019.03.036
Rattus norvegicus Rattus norvegicus Activity 4.2 % 10.1016/j.bmcl.2015.10.047
Rattus norvegicus Rattus norvegicus Activity 5.5 umol 10.1016/j.ejmech.2014.05.012
Rattus norvegicus Rattus norvegicus Activity 5.8 % 10.1016/j.bmcl.2017.02.076
Rattus norvegicus Rattus norvegicus Activity 6.3 nmol 10.1016/j.ejmech.2014.05.012
Rattus norvegicus Rattus norvegicus Activity 6.66 % 10.1016/j.ejmech.2012.06.048
Rattus norvegicus Rattus norvegicus Activity 7.9 nmol/min/ml 10.1016/j.ejmech.2014.05.012
Rattus norvegicus Rattus norvegicus Activity 8.2 mm2 10.1021/jm070821f
Rattus norvegicus Rattus norvegicus Activity 8.6 % 10.1016/j.ejmech.2019.03.036
Rattus norvegicus Rattus norvegicus Activity 10.0 % 10.1016/j.ejmech.2019.03.036
Rattus norvegicus Rattus norvegicus Activity 11.4 % 10.1016/j.ejmech.2019.03.036
Rattus norvegicus Rattus norvegicus Activity 12.9 % 10.1016/j.ejmech.2019.03.036
Rattus norvegicus Rattus norvegicus Activity 15.7 % 10.1016/j.ejmech.2021.113804
Rattus norvegicus Rattus norvegicus Activity 16.2 % 10.1016/j.bmcl.2017.02.076
Rattus norvegicus Rattus norvegicus Activity 17.0 % 10.1016/j.ejmech.2012.10.014
Rattus norvegicus Rattus norvegicus Activity 17.0 % 10.1021/jm070821f
Rattus norvegicus Rattus norvegicus Activity 18.61 % 10.1039/C6MD00367B
Rattus norvegicus Rattus norvegicus Activity 19.7 % 10.1016/j.bmcl.2017.02.076
Rattus norvegicus Rattus norvegicus Activity 23.05 % 10.1016/j.ejmech.2013.12.033
Rattus norvegicus Rattus norvegicus Activity 24.0 % 10.1021/jm070821f
Rattus norvegicus Rattus norvegicus Activity 24.02 % 10.1016/j.ejmech.2013.12.033
Rattus norvegicus Rattus norvegicus Activity 26.0 % 10.1021/jm070821f
Rattus norvegicus Rattus norvegicus Activity 26.6 % 10.1016/j.bmcl.2017.02.076
Rattus norvegicus Rattus norvegicus Activity 26.9 % 10.1016/j.ejmech.2020.112066
Rattus norvegicus Rattus norvegicus Activity 28.87 % 10.1016/j.ejmech.2013.12.033
Rattus norvegicus Rattus norvegicus Activity 32.0 g 10.1021/jm070821f
Rattus norvegicus Rattus norvegicus Activity 34.0 % 10.1021/jm070821f
Rattus norvegicus Rattus norvegicus Activity 35.0 % 10.1016/j.bmcl.2012.08.018
Rattus norvegicus Rattus norvegicus Activity 36.5 % 10.1016/j.ejmech.2020.112066
Rattus norvegicus Rattus norvegicus Activity 36.6 % 10.1016/j.ejmech.2020.112066
Rattus norvegicus Rattus norvegicus Activity 39.0 % 10.1016/j.ejmech.2012.10.014
Rattus norvegicus Rattus norvegicus Activity 39.67 % 10.1016/j.bmc.2009.05.073
Rattus norvegicus Rattus norvegicus Activity 39.8 g 10.1021/jm301370e
Rattus norvegicus Rattus norvegicus Activity 40.0 % 10.1016/j.bmcl.2008.10.105
Rattus norvegicus Rattus norvegicus Activity 40.6 % 10.1016/j.ejmech.2020.112066
Rattus norvegicus Rattus norvegicus Activity 40.7 g 10.1021/jm301370e
Rattus norvegicus Rattus norvegicus Activity 41.0 % 10.1016/j.bmc.2010.01.021
Rattus norvegicus Rattus norvegicus Activity 41.6 g 10.1021/jm301370e
Rattus norvegicus Rattus norvegicus Activity 42.94 % 10.1007/s00044-012-9975-3
Rattus norvegicus Rattus norvegicus Activity 44.3 g 10.1021/jm301370e
Rattus norvegicus Rattus norvegicus Activity 45.0 % 10.1016/j.ejmech.2012.10.014
Rattus norvegicus Rattus norvegicus Activity 46.7 g 10.1016/j.ejmech.2022.114615
Rattus norvegicus Rattus norvegicus Activity 48.3 g 10.1021/jm301370e
Rattus norvegicus Rattus norvegicus Activity 48.31 % 10.1016/j.bmc.2007.09.038
Rattus norvegicus Rattus norvegicus Activity 48.5 g 10.1016/j.ejmech.2022.114615
Rattus norvegicus Rattus norvegicus Activity 50.0 % 10.1016/j.bmc.2010.01.021
Rattus norvegicus Rattus norvegicus Activity 51.3 g 10.1016/j.ejmech.2022.114615
Rattus norvegicus Rattus norvegicus Activity 52.9 g 10.1021/jm301370e
Rattus norvegicus Rattus norvegicus Activity 54.0 % 10.1021/jm070821f
Rattus norvegicus Rattus norvegicus Activity 54.0 g 10.1016/j.ejmech.2022.114615
Rattus norvegicus Rattus norvegicus Activity 54.3 g 10.1021/jm200715n
Rattus norvegicus Rattus norvegicus Activity 54.9 g 10.1021/jm200715n
Rattus norvegicus Rattus norvegicus Activity 55.2 g 10.1016/j.bmc.2008.07.058
Rattus norvegicus Rattus norvegicus Activity 55.2 g 10.1021/jm0707525
Rattus norvegicus Rattus norvegicus Activity 55.2 g 10.1021/jm901269y
Rattus norvegicus Rattus norvegicus Activity 56.0 % 10.1016/j.ejmech.2012.10.014
Rattus norvegicus Rattus norvegicus Activity 56.5 g 10.1016/j.bmc.2008.07.058
Rattus norvegicus Rattus norvegicus Activity 56.5 g 10.1021/jm0707525
Rattus norvegicus Rattus norvegicus Activity 56.5 g 10.1021/jm901269y
Rattus norvegicus Rattus norvegicus Activity 57.06 % 10.1007/s00044-012-9975-3
Rattus norvegicus Rattus norvegicus Activity 57.1 g 10.1021/jm200715n
Rattus norvegicus Rattus norvegicus Activity 57.14 % 10.1016/j.ejmech.2020.112438
Rattus norvegicus Rattus norvegicus Activity 58.2 g 10.1016/j.bmc.2008.07.058
Rattus norvegicus Rattus norvegicus Activity 58.2 g 10.1021/jm0707525
Rattus norvegicus Rattus norvegicus Activity 58.2 g 10.1021/jm901269y
Rattus norvegicus Rattus norvegicus Activity 60.0 % 10.1016/j.bmc.2010.01.021
Rattus norvegicus Rattus norvegicus Activity 62.26 % 10.1016/j.ejmech.2018.11.027
Rattus norvegicus Rattus norvegicus Activity 64.83 % 10.1016/j.bmc.2007.09.038
Rattus norvegicus Rattus norvegicus Activity 68.0 % 10.1016/j.bmc.2010.01.021
Rattus norvegicus Rattus norvegicus Activity 69.0 % 10.1016/j.ejmech.2020.112438
Rattus norvegicus Rattus norvegicus Activity 72.0 % 10.1016/j.ejmech.2020.112438
Rattus norvegicus Rattus norvegicus Activity 73.56 % 10.1016/j.ejmech.2021.113804
Rattus norvegicus Rattus norvegicus Activity 74.56 % 10.1016/j.bmcl.2020.127743
Rattus norvegicus Rattus norvegicus Activity 75.0 % 10.1016/j.ejmech.2012.10.014
Rattus norvegicus Rattus norvegicus Activity 77.3 % 10.1016/j.ejmech.2010.10.001
Rattus norvegicus Rattus norvegicus Activity 77.5 % 10.1016/j.bmc.2008.04.007
Rattus norvegicus Rattus norvegicus Activity 78.0 % 10.1016/j.bmcl.2020.127743
Rattus norvegicus Rattus norvegicus Activity 79.5 % 10.1016/j.bmcl.2008.10.105
Rattus norvegicus Rattus norvegicus Activity 83.4 % 10.1016/j.ejmech.2021.113493
Rattus norvegicus Rattus norvegicus Activity 87.59 % 10.1016/j.ejmech.2020.112438
Rattus norvegicus Rattus norvegicus Activity 90.23 g 10.1039/C6MD00367B
Rattus norvegicus Rattus norvegicus Activity 95.5 % 10.1021/jm0707525
Rattus norvegicus Rattus norvegicus Activity 95.5 % 10.1021/jm901269y
Rattus norvegicus Rattus norvegicus Activity 96.73 % 10.1016/j.ejmech.2017.09.056
Rattus norvegicus Rattus norvegicus Activity 100.0 % 10.1016/j.ejmech.2014.06.049
Rattus norvegicus Rattus norvegicus Activity 104.23 None 10.1016/j.bmc.2008.04.007
Rattus norvegicus Rattus norvegicus Activity 105.6 % 10.1016/j.ejmech.2010.10.001
Rattus norvegicus Rattus norvegicus Activity 176.45 g 10.1016/j.ejmech.2019.111601
Rattus norvegicus Rattus norvegicus Activity 176.63 g 10.1016/j.ejmech.2019.111601
Rattus norvegicus Rattus norvegicus Activity 176.87 g 10.1016/j.ejmech.2019.111601
Rattus norvegicus Rattus norvegicus Activity 180.82 g 10.1016/j.ejmech.2019.111601
Rattus norvegicus Rattus norvegicus Activity 200.0 mg kg-1 10.1016/j.bmc.2016.03.032
Rattus norvegicus Rattus norvegicus Activity 234.0 mm 10.1016/j.ejmech.2020.112066
Rattus norvegicus Rattus norvegicus Activity 267.43 g 10.1016/j.ejmech.2019.111601
Rattus norvegicus Rattus norvegicus Activity 269.55 g 10.1016/j.ejmech.2019.111601
Rattus norvegicus Rattus norvegicus Activity 270.66 g 10.1016/j.ejmech.2019.111601
Rattus norvegicus Rattus norvegicus Activity 270.89 g 10.1016/j.ejmech.2019.111601
Rattus norvegicus Rattus norvegicus Activity 273.46 g 10.1016/j.ejmech.2019.111601
Rattus norvegicus Rattus norvegicus Activity nan None 10.1016/j.bmc.2014.09.028
Rattus norvegicus Rattus norvegicus Activity nan None 10.1016/j.bmcl.2006.06.032
Rattus norvegicus Rattus norvegicus Activity nan None 10.1016/j.bmcl.2010.07.033
Rattus norvegicus Rattus norvegicus Activity nan None 10.1016/j.bmcl.2017.08.023
Rattus norvegicus Rattus norvegicus Activity nan None 10.1016/j.bmcl.2018.03.091
Rattus norvegicus Rattus norvegicus Activity nan None 10.1016/j.bmcl.2020.127754
Rattus norvegicus Rattus norvegicus Activity nan None 10.1016/j.bmcl.2022.128805
Rattus norvegicus Rattus norvegicus Activity nan None 10.1016/j.ejmech.2012.06.048
Rattus norvegicus Rattus norvegicus Activity nan None 10.1016/j.ejmech.2016.12.030
Rattus norvegicus Rattus norvegicus Activity nan None 10.1016/j.ejmech.2017.12.065
Rattus norvegicus Rattus norvegicus Activity nan None 10.1021/acs.jmedchem.5b00132
Rattus norvegicus Rattus norvegicus Activity nan None 10.1021/jm0602256
Rattus norvegicus Rattus norvegicus Activity nan None 10.1021/jm2001376
Rattus norvegicus Rattus norvegicus Activity nan None 10.1021/jm701467e
Rattus norvegicus Rattus norvegicus Activity nan None 10.1021/jm900702b
Rattus norvegicus Rattus norvegicus ALB 34000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALB 34400.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALB 35000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALB 35300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALB 35700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALB 36700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALB 39000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALB 39300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALB 39700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALB 42000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 284.5 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 324.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 347.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 354.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 409.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 437.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 443.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 444.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 449.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 451.2 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALT 41.6 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALT 42.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALT 48.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALT 52.5 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALT 62.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALT 69.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALT 70.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALT 76.83 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALT 77.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AST 63.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AST 64.8 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AST 65.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AST 74.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AST 79.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AST 80.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AST 81.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AST 82.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AST 83.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AST 97.17 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AUC 23160.0 ng.hr.mL-1 10.1021/jm020563g
Rattus norvegicus Rattus norvegicus BASO 0.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BASO 0.0233 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BASO 0.03 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BASO 0.0567 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BASO 0.19 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BASOLE 0.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BASOLE 0.2 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BASOLE 0.27 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BASOLE 0.5 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BASOLE 1.28 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BILI 1.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BILI 2.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BILI 3.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BILI 4.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BUN 90.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BUN 93.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BUN 96.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BUN 103.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BUN 106.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BUN 112.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BUN 123.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BUN 143.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BUN 160.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHLORIDE 99.5 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHLORIDE 100.33 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHLORIDE 101.0 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHLORIDE 102.67 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHLORIDE 103.0 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHLORIDE 103.33 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHLORIDE 104.33 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHLORIDE 105.67 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHLORIDE 105.8 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHLORIDE 106.67 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 460.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 510.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 526.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 563.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 686.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 748.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 766.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 883.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 916.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CK 166.4 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CK 179.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CK 191.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CK 192.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CK 247.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CK 260.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CK 356.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CK 374.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CK 448.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CK 659.17 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus Cmax 6476.48 nM 10.1021/jm020563g
Rattus norvegicus Rattus norvegicus CO2 21000000.0 nM 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CO2 22000000.0 nM 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CO2 22670000.0 nM 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CO2 25000000.0 nM 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CO2 25330000.0 nM 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CO2 25500000.0 nM 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus Cp 129.0 ng/ml 10.1021/jm701467e
Rattus norvegicus Rattus norvegicus Cp 1130.0 ng/ml 10.1021/jm701467e
Rattus norvegicus Rattus norvegicus CREAT 1.1 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CREAT 1.2 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CREAT 1.5 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CREAT 3.2 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CREAT 3.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CREAT 3.4 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CREAT 3.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus Cr secretion 0.7 % 10.1021/jm030765s
Rattus norvegicus Rattus norvegicus EC50 0.33 mg kg-1 10.1021/jm990577v
Rattus norvegicus Rattus norvegicus EC50 0.373 mg kg-1 10.1021/jm990577v
Rattus norvegicus Rattus norvegicus EC50 0.69 mg kg-1 10.1021/ml500299q
Rattus norvegicus Rattus norvegicus EC50 2.81 mg kg-1 10.1021/ml500299q
Rattus norvegicus Rattus norvegicus EC50 5.0 mg kg-1 10.1021/ml500299q
Rattus norvegicus Rattus norvegicus EC50 7.13 mg kg-1 10.1021/jm990577v
Rattus norvegicus Rattus norvegicus ED30 23.0 mg kg-1 10.1021/jm070821f
Rattus norvegicus Rattus norvegicus ED30 30.0 mg kg-1 10.1021/jm070821f
Rattus norvegicus Rattus norvegicus ED30 nan None 10.1021/jm020563g
Rattus norvegicus Rattus norvegicus ED35 1.1 mg kg-1 10.1021/jm991106b
Rattus norvegicus Rattus norvegicus ED35 3.0 mg kg-1 10.1021/jm991106b
Rattus norvegicus Rattus norvegicus ED50 0.086 umol.kg-1 10.1016/j.ejmech.2014.04.065
Rattus norvegicus Rattus norvegicus ED50 0.089 umol.kg-1 10.1016/j.ejmech.2014.04.065
Rattus norvegicus Rattus norvegicus ED50 0.2 mg kg-1 day-1 10.1016/s0960-894x(00)00634-x
Rattus norvegicus Rattus norvegicus ED50 0.2 mg kg-1 day-1 10.1021/jm020545z
Rattus norvegicus Rattus norvegicus ED50 0.2 mg/kg/day 10.1016/j.ejmech.2019.03.021
Rattus norvegicus Rattus norvegicus ED50 0.3 mg.kg-1 10.1016/j.bmcl.2010.07.053
Rattus norvegicus Rattus norvegicus ED50 0.32 mg kg-1 day-1 10.1021/jm990965x
Rattus norvegicus Rattus norvegicus ED50 0.37 mg.kg-1 10.1016/s0960-894x(98)00627-1
Rattus norvegicus Rattus norvegicus ED50 0.37 mg.kg-1 10.1021/jm010484p
Rattus norvegicus Rattus norvegicus ED50 0.37 mg.kg-1 10.1021/jm960803q
Rattus norvegicus Rattus norvegicus ED50 0.37 mg kg-1 day-1 10.1021/jm020545z
Rattus norvegicus Rattus norvegicus ED50 0.37 mg kg-1 day-1 10.1021/jm990965x
Rattus norvegicus Rattus norvegicus ED50 0.5 mg.kg-1 10.1021/jm991106b
Rattus norvegicus Rattus norvegicus ED50 0.6 mg.kg-1 10.1021/jm991106b
Rattus norvegicus Rattus norvegicus ED50 0.69 mg.kg-1 10.1021/acs.jmedchem.6b01484
Rattus norvegicus Rattus norvegicus ED50 0.71 mg.kg-1 10.1021/acs.jmedchem.6b01484
Rattus norvegicus Rattus norvegicus ED50 1.57 mg.kg-1 10.1021/ml500299q
Rattus norvegicus Rattus norvegicus ED50 1.6 mg.kg-1 10.1021/acs.jmedchem.6b01484
Rattus norvegicus Rattus norvegicus ED50 2.8 mg.kg-1 10.1021/acs.jmedchem.6b01484
Rattus norvegicus Rattus norvegicus ED50 2.8 mg.kg-1 10.1021/jm010484p
Rattus norvegicus Rattus norvegicus ED50 3.2 mg.kg-1 10.1016/s0960-894x(03)00046-5
Rattus norvegicus Rattus norvegicus ED50 3.2 mg.kg-1 10.1021/jm980642l
Rattus norvegicus Rattus norvegicus ED50 5.0 mg.kg-1 10.1021/acs.jmedchem.6b01484
Rattus norvegicus Rattus norvegicus ED50 6.2 mg.kg-1 10.1021/jm991106b
Rattus norvegicus Rattus norvegicus ED50 6.7 mg.kg-1 10.1016/j.bmcl.2006.05.028
Rattus norvegicus Rattus norvegicus ED50 7.1 mg.kg-1 10.1021/jm960803q
Rattus norvegicus Rattus norvegicus ED50 7.9 mg.kg-1 10.1021/jm020563g
Rattus norvegicus Rattus norvegicus ED50 9.2 mg.kg-1 10.1021/acs.jmedchem.6b01484
Rattus norvegicus Rattus norvegicus ED50 10.8 mg.kg-1 10.1016/j.bmc.2008.08.059
Rattus norvegicus Rattus norvegicus ED50 10.8 mg.kg-1 10.1016/j.bmcl.2008.10.009
Rattus norvegicus Rattus norvegicus ED50 10.8 mg.kg-1 10.1016/j.bmcl.2008.12.066
Rattus norvegicus Rattus norvegicus ED50 10.8 mg.kg-1 10.1016/j.bmcl.2010.01.014
Rattus norvegicus Rattus norvegicus ED50 10.8 mg.kg-1 10.1021/acs.jmedchem.9b01183
Rattus norvegicus Rattus norvegicus ED50 10.8 mg.kg-1 10.1021/jm0510474
Rattus norvegicus Rattus norvegicus ED50 10.8 mg.kg-1 10.1021/jm8015188
Rattus norvegicus Rattus norvegicus ED50 14.3 mg.kg-1 10.1016/j.bmc.2010.01.021
Rattus norvegicus Rattus norvegicus ED50 15.65 mg.kg-1 10.1016/j.bmc.2010.06.018
Rattus norvegicus Rattus norvegicus ED50 16.7 umol.kg-1 10.1016/j.bmc.2008.04.007
Rattus norvegicus Rattus norvegicus ED50 16.74 umol 10.1016/j.ejmech.2010.10.001
Rattus norvegicus Rattus norvegicus ED50 30.9 umol.kg-1 10.1016/j.bmc.2008.10.001
Rattus norvegicus Rattus norvegicus ED50 30.9 umol.kg-1 10.1016/j.bmc.2009.05.046
Rattus norvegicus Rattus norvegicus ED50 30.9 umol.kg-1 10.1016/j.bmcl.2010.06.022
Rattus norvegicus Rattus norvegicus ED50 30.9 umol.kg-1 10.1016/j.bmcl.2011.05.017
Rattus norvegicus Rattus norvegicus ED50 32.0 umol.kg-1 10.1016/j.ejmech.2021.113493
Rattus norvegicus Rattus norvegicus ED50 34.1 mg.kg-1 10.1016/j.ejmech.2021.113493
Rattus norvegicus Rattus norvegicus ED50 34.5 mg.kg-1 10.1021/jm960803q
Rattus norvegicus Rattus norvegicus ED50 35.0 mg.kg-1 10.1016/j.bmcl.2010.07.053
Rattus norvegicus Rattus norvegicus ED50 35.0 mg.kg-1 10.1016/j.bmcl.2017.08.023
Rattus norvegicus Rattus norvegicus ED50 47.0 umol.kg-1 10.1016/j.bmcl.2015.11.105
Rattus norvegicus Rattus norvegicus ED50 47.0 umol.kg-1 10.1016/j.bmcl.2016.04.046
Rattus norvegicus Rattus norvegicus ED50 81.7 mg.kg-1 10.1016/j.ejmech.2014.04.045
Rattus norvegicus Rattus norvegicus ED50 83.4 mg.kg-1 10.1016/j.bmc.2016.06.026
Rattus norvegicus Rattus norvegicus ED50 83.4 mg.kg-1 10.1016/j.bmcl.2013.02.107
Rattus norvegicus Rattus norvegicus ED50 83.4 mg.kg-1 10.1016/j.ejmech.2014.12.039
Rattus norvegicus Rattus norvegicus ED50 84.3 mg.kg-1 10.1016/j.ejmech.2016.05.066
Rattus norvegicus Rattus norvegicus ED50 86.11 umol 10.1016/j.ejmech.2017.09.056
Rattus norvegicus Rattus norvegicus ED50 86.4 mg.kg-1 10.1016/j.ejmech.2016.03.011
Rattus norvegicus Rattus norvegicus ED50 87.7 umol.kg-1 10.1016/j.bmc.2008.11.018
Rattus norvegicus Rattus norvegicus ED50 89.0 mg.kg-1 10.1016/j.bmc.2016.03.032
Rattus norvegicus Rattus norvegicus ED50 185.0 umol.kg-1 10.1016/j.bmc.2012.03.044
Rattus norvegicus Rattus norvegicus EOS 0.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOS 104.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOS 104.17 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOS 252.67 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOS 278.33 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOS 331.5 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOSLE 0.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOSLE 0.17 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOSLE 0.3 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOSLE 0.57 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOSLE 0.6 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOSLE 0.67 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOSLE 1.33 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOSLE 1.67 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOSLE 1.83 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus FC 1.0 None 10.1016/j.bmcl.2017.08.023
Rattus norvegicus Rattus norvegicus GLUC 1606.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus GLUC 1641.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus GLUC 1643.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus GLUC 1773.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus GLUC 1800.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus GLUC 1823.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus GLUC 1858.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus GLUC 1873.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus GLUC 1890.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus GLUC 1916.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 33.22 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 33.67 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 34.37 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 36.13 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 37.23 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 42.57 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 42.7 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 43.47 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 43.8 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HGB 132000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HGB 132600.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HGB 133800.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HGB 135300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HGB 139700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HGB 140000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HGB 141000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HGB 141700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HGB 142300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HGB 142700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus Hgb levels 13.2 g dl-1 10.1021/jm991106b
Rattus norvegicus Rattus norvegicus ID50 10.8 mg.kg-1 10.1016/j.bmc.2007.11.003
Rattus norvegicus Rattus norvegicus ID50 10.8 mg.kg-1 10.1016/j.bmc.2008.05.028
Rattus norvegicus Rattus norvegicus ID50 10.8 mg.kg-1 10.1021/jm0101287
Rattus norvegicus Rattus norvegicus ID50 40.8 mg.kg-1 10.1021/jm0101287
Rattus norvegicus Rattus norvegicus Inhibition 6.06 % 10.1016/j.ejmech.2019.03.052
Rattus norvegicus Rattus norvegicus Inhibition 6.49 % 10.1016/j.ejmech.2013.10.083
Rattus norvegicus Rattus norvegicus Inhibition 8.99 % 10.1016/j.ejmech.2019.03.052
Rattus norvegicus Rattus norvegicus Inhibition 10.8 % 10.1016/j.bmcl.2011.08.053
Rattus norvegicus Rattus norvegicus Inhibition 11.11 % 10.1016/j.ejmech.2019.03.052
Rattus norvegicus Rattus norvegicus Inhibition 12.3 % 10.1021/jm070821f
Rattus norvegicus Rattus norvegicus Inhibition 15.67 % 10.1016/j.ejmech.2013.12.033
Rattus norvegicus Rattus norvegicus Inhibition 15.67 % 10.1021/jm900702b
Rattus norvegicus Rattus norvegicus Inhibition 17.86 % 10.1016/j.ejmech.2013.10.083
Rattus norvegicus Rattus norvegicus Inhibition 18.0 % 10.1021/jm070821f
Rattus norvegicus Rattus norvegicus Inhibition 18.6 % 10.1021/jm070821f
Rattus norvegicus Rattus norvegicus Inhibition 19.0 % 10.1021/jm070821f
Rattus norvegicus Rattus norvegicus Inhibition 20.0 % 10.1016/j.ejmech.2016.12.030
Rattus norvegicus Rattus norvegicus Inhibition 23.5 % 10.1016/j.bmcl.2009.02.090
Rattus norvegicus Rattus norvegicus Inhibition 24.2 % 10.1021/jm070821f
Rattus norvegicus Rattus norvegicus Inhibition 24.38 % 10.1016/j.bmcl.2014.08.050
Rattus norvegicus Rattus norvegicus Inhibition 27.32 % 10.1016/j.ejmech.2013.12.033
Rattus norvegicus Rattus norvegicus Inhibition 27.32 % 10.1021/jm900702b
Rattus norvegicus Rattus norvegicus Inhibition 29.0 % 10.1016/j.bmcl.2004.02.028
Rattus norvegicus Rattus norvegicus Inhibition 30.0 % 10.1016/j.bmc.2008.11.018
Rattus norvegicus Rattus norvegicus Inhibition 31.0 % 10.1016/s0960-894x(00)00634-x
Rattus norvegicus Rattus norvegicus Inhibition 31.43 % 10.1007/s00044-011-9691-4
Rattus norvegicus Rattus norvegicus Inhibition 31.7 % 10.1021/jm0101287
Rattus norvegicus Rattus norvegicus Inhibition 31.7 % 10.1021/jm010153c
Rattus norvegicus Rattus norvegicus Inhibition 31.7 % 10.1021/jm0302391
Rattus norvegicus Rattus norvegicus Inhibition 32.49 % 10.1016/j.ejmech.2013.10.083
Rattus norvegicus Rattus norvegicus Inhibition 33.33 % 10.1016/j.ejmech.2017.12.065
Rattus norvegicus Rattus norvegicus Inhibition 34.0 % 10.1016/j.ejmech.2012.06.048
Rattus norvegicus Rattus norvegicus Inhibition 34.0 % 10.1021/jm020545z
Rattus norvegicus Rattus norvegicus Inhibition 34.6 % 10.1039/C9MD00228F
Rattus norvegicus Rattus norvegicus Inhibition 34.95 % 10.1016/j.ejmech.2019.03.052
Rattus norvegicus Rattus norvegicus Inhibition 35.7 % 10.1021/jm030765s
Rattus norvegicus Rattus norvegicus Inhibition 36.6 % 10.1016/j.bmcl.2009.02.090
Rattus norvegicus Rattus norvegicus Inhibition 36.8 % 10.1016/j.ejmech.2019.02.034
Rattus norvegicus Rattus norvegicus Inhibition 36.96 % 10.1016/j.ejmech.2019.111780
Rattus norvegicus Rattus norvegicus Inhibition 37.0 % 10.1016/j.bmc.2010.06.018
Rattus norvegicus Rattus norvegicus Inhibition 37.0 % 10.1021/jm701467e
Rattus norvegicus Rattus norvegicus Inhibition 38.0 % 10.1016/j.bmc.2010.06.018
Rattus norvegicus Rattus norvegicus Inhibition 38.82 % 10.1016/j.bmcl.2014.08.050
Rattus norvegicus Rattus norvegicus Inhibition 39.62 % 10.1016/j.bmcl.2012.08.119
Rattus norvegicus Rattus norvegicus Inhibition 40.0 % 10.1016/j.bmcl.2014.09.024
Rattus norvegicus Rattus norvegicus Inhibition 40.0 % 10.1016/s0960-894x(01)00534-0
Rattus norvegicus Rattus norvegicus Inhibition 41.0 % 10.1016/j.bmc.2010.06.018
Rattus norvegicus Rattus norvegicus Inhibition 41.0 % 10.1016/s0960-894x(01)00534-0
Rattus norvegicus Rattus norvegicus Inhibition 41.9 % 10.1016/j.ejmech.2013.10.083
Rattus norvegicus Rattus norvegicus Inhibition 42.0 % 10.1016/j.bmcl.2004.02.028
Rattus norvegicus Rattus norvegicus Inhibition 42.0 % 10.1016/j.ejmech.2014.03.001
Rattus norvegicus Rattus norvegicus Inhibition 42.09 % 10.1016/j.ejmech.2013.12.033
Rattus norvegicus Rattus norvegicus Inhibition 42.09 % 10.1021/jm900702b
Rattus norvegicus Rattus norvegicus Inhibition 42.61 % 10.1016/j.ejmech.2019.03.052
Rattus norvegicus Rattus norvegicus Inhibition 43.0 % 10.1021/jm0009383
Rattus norvegicus Rattus norvegicus Inhibition 43.84 % 10.1016/j.ejmech.2019.03.042
Rattus norvegicus Rattus norvegicus Inhibition 44.0 % 10.1016/j.ejmech.2014.06.049
Rattus norvegicus Rattus norvegicus Inhibition 44.7 % 10.1016/j.bmcl.2009.02.090
Rattus norvegicus Rattus norvegicus Inhibition 44.9 % 10.1039/C9MD00228F
Rattus norvegicus Rattus norvegicus Inhibition 45.0 % 10.1016/j.bmc.2012.03.069
Rattus norvegicus Rattus norvegicus Inhibition 45.33 % 10.1016/j.bmc.2017.07.038
Rattus norvegicus Rattus norvegicus Inhibition 45.75 % 10.1007/s00044-011-9691-4
Rattus norvegicus Rattus norvegicus Inhibition 46.0 % 10.1016/j.bmc.2010.06.018
Rattus norvegicus Rattus norvegicus Inhibition 46.4 % 10.1016/j.ejmech.2020.112438
Rattus norvegicus Rattus norvegicus Inhibition 47.0 % 10.1016/j.bmc.2010.06.018
Rattus norvegicus Rattus norvegicus Inhibition 47.0 % 10.1016/j.ejmech.2012.06.048
Rattus norvegicus Rattus norvegicus Inhibition 47.62 % 10.1016/j.ejmech.2019.03.042
Rattus norvegicus Rattus norvegicus Inhibition 48.0 % 10.1016/j.bmcl.2014.09.024
Rattus norvegicus Rattus norvegicus Inhibition 48.0 % 10.1016/j.ejmech.2012.06.048
Rattus norvegicus Rattus norvegicus Inhibition 48.0 % 10.1016/j.ejmech.2014.03.001
Rattus norvegicus Rattus norvegicus Inhibition 48.1 % 10.1039/C9MD00228F
Rattus norvegicus Rattus norvegicus Inhibition 48.2 % 10.1016/j.ejmech.2013.10.083
Rattus norvegicus Rattus norvegicus Inhibition 49.0 % 10.1021/jm020563g
Rattus norvegicus Rattus norvegicus Inhibition 49.3 % 10.1016/j.bmcl.2009.02.090
Rattus norvegicus Rattus norvegicus Inhibition 50.0 % 10.1016/j.bmc.2006.12.041
Rattus norvegicus Rattus norvegicus Inhibition 50.0 % 10.1016/j.bmc.2010.01.021
Rattus norvegicus Rattus norvegicus Inhibition 50.0 % 10.1016/j.ejmech.2014.06.049
Rattus norvegicus Rattus norvegicus Inhibition 51.0 % 10.1016/j.ejmech.2014.03.001
Rattus norvegicus Rattus norvegicus Inhibition 51.44 % 10.1016/j.bmcl.2014.08.050
Rattus norvegicus Rattus norvegicus Inhibition 52.0 % 10.1016/j.ejmech.2014.06.049
Rattus norvegicus Rattus norvegicus Inhibition 53.19 % 10.1016/j.ejmech.2019.03.042
Rattus norvegicus Rattus norvegicus Inhibition 54.0 % 10.1016/j.bmc.2010.01.021
Rattus norvegicus Rattus norvegicus Inhibition 54.0 % 10.1016/j.ejmech.2012.06.048
Rattus norvegicus Rattus norvegicus Inhibition 54.21 % 10.1007/s00044-011-9606-4
Rattus norvegicus Rattus norvegicus Inhibition 55.0 % 10.1016/j.ejmech.2017.06.044
Rattus norvegicus Rattus norvegicus Inhibition 55.0 % 10.1021/jm070821f
Rattus norvegicus Rattus norvegicus Inhibition 56.0 % 10.1016/j.bmc.2010.06.018
Rattus norvegicus Rattus norvegicus Inhibition 56.1 % 10.1039/C9MD00228F
Rattus norvegicus Rattus norvegicus Inhibition 57.0 % 10.1016/j.bmc.2012.03.044
Rattus norvegicus Rattus norvegicus Inhibition 57.0 % 10.1016/j.ejmech.2014.03.001
Rattus norvegicus Rattus norvegicus Inhibition 57.08 % 10.1016/j.ejmech.2016.11.006
Rattus norvegicus Rattus norvegicus Inhibition 58.2 % 10.1021/jm0101287
Rattus norvegicus Rattus norvegicus Inhibition 58.2 % 10.1021/jm010153c
Rattus norvegicus Rattus norvegicus Inhibition 58.2 % 10.1021/jm0302391
Rattus norvegicus Rattus norvegicus Inhibition 58.5 % 10.1039/C9MD00228F
Rattus norvegicus Rattus norvegicus Inhibition 58.59 % 10.1016/j.bmcl.2012.08.119
Rattus norvegicus Rattus norvegicus Inhibition 59.0 % 10.1016/j.ejmech.2014.06.049
Rattus norvegicus Rattus norvegicus Inhibition 59.0 % 10.1016/j.ejmech.2017.06.044
Rattus norvegicus Rattus norvegicus Inhibition 59.68 % 10.1016/j.ejmech.2016.04.049
Rattus norvegicus Rattus norvegicus Inhibition 60.57 % 10.1021/ml400500e
Rattus norvegicus Rattus norvegicus Inhibition 61.0 % 10.1016/j.ejmech.2017.06.044
Rattus norvegicus Rattus norvegicus Inhibition 61.07 % 10.1007/s00044-011-9606-4
Rattus norvegicus Rattus norvegicus Inhibition 62.0 % 10.1021/jm0101287
Rattus norvegicus Rattus norvegicus Inhibition 62.0 % 10.1021/jm010153c
Rattus norvegicus Rattus norvegicus Inhibition 62.0 % 10.1021/jm0302391
Rattus norvegicus Rattus norvegicus Inhibition 62.75 % 10.1007/s00044-011-9606-4
Rattus norvegicus Rattus norvegicus Inhibition 62.9 % 10.1016/j.ejmech.2019.03.042
Rattus norvegicus Rattus norvegicus Inhibition 63.78 % 10.1007/s00044-011-9691-4
Rattus norvegicus Rattus norvegicus Inhibition 63.97 % 10.1007/s00044-011-9606-4
Rattus norvegicus Rattus norvegicus Inhibition 65.0 % 10.1016/j.bmcl.2017.08.023
Rattus norvegicus Rattus norvegicus Inhibition 65.33 % 10.1016/j.bmcl.2015.10.047
Rattus norvegicus Rattus norvegicus Inhibition 65.55 % 10.1016/j.ejmech.2014.05.012
Rattus norvegicus Rattus norvegicus Inhibition 65.63 % 10.1016/j.ejmech.2016.04.049
Rattus norvegicus Rattus norvegicus Inhibition 66.96 % 10.1016/j.bmc.2014.09.028
Rattus norvegicus Rattus norvegicus Inhibition 67.0 % 10.1016/j.bmc.2021.116091
Rattus norvegicus Rattus norvegicus Inhibition 67.37 % 10.1016/j.ejmech.2019.111780
Rattus norvegicus Rattus norvegicus Inhibition 68.0 % 10.1016/j.bmc.2021.116091
Rattus norvegicus Rattus norvegicus Inhibition 68.0 % 10.1016/j.ejmech.2014.03.001
Rattus norvegicus Rattus norvegicus Inhibition 68.36 % 10.1016/j.bmc.2017.07.038
Rattus norvegicus Rattus norvegicus Inhibition 68.39 % 10.1016/j.ejmech.2016.11.006
Rattus norvegicus Rattus norvegicus Inhibition 69.0 % 10.1016/j.ejmech.2014.06.049
Rattus norvegicus Rattus norvegicus Inhibition 69.3 % 10.1021/jm049523y
Rattus norvegicus Rattus norvegicus Inhibition 69.3 % 10.1021/jm0510474
Rattus norvegicus Rattus norvegicus Inhibition 69.33 % 10.1021/jm049939b
Rattus norvegicus Rattus norvegicus Inhibition 69.61 % 10.1016/j.ejmech.2019.03.052
Rattus norvegicus Rattus norvegicus Inhibition 70.0 % 10.1016/j.bmc.2021.116091
Rattus norvegicus Rattus norvegicus Inhibition 70.53 % 10.1016/j.bmc.2006.12.041
Rattus norvegicus Rattus norvegicus Inhibition 71.21 % 10.1016/j.ejmech.2016.11.006
Rattus norvegicus Rattus norvegicus Inhibition 71.3 % 10.1021/jm0009383
Rattus norvegicus Rattus norvegicus Inhibition 72.0 % 10.1016/j.ejmech.2016.12.030
Rattus norvegicus Rattus norvegicus Inhibition 72.22 % 10.1016/j.ejmech.2014.05.012
Rattus norvegicus Rattus norvegicus Inhibition 72.96 % 10.1016/j.bmcl.2016.12.069
Rattus norvegicus Rattus norvegicus Inhibition 74.0 % 10.1016/j.bmc.2021.116091
Rattus norvegicus Rattus norvegicus Inhibition 74.56 % 10.1016/j.bmcl.2016.12.069
Rattus norvegicus Rattus norvegicus Inhibition 74.61 % 10.1021/ml400500e
Rattus norvegicus Rattus norvegicus Inhibition 75.9 % 10.1007/s00044-012-0130-y
Rattus norvegicus Rattus norvegicus Inhibition 77.0 % 10.1016/j.ejmech.2016.12.030
Rattus norvegicus Rattus norvegicus Inhibition 77.25 % 10.1016/j.ejmech.2017.09.056
Rattus norvegicus Rattus norvegicus Inhibition 77.67 % 10.1016/j.bmcl.2016.12.069
Rattus norvegicus Rattus norvegicus Inhibition 78.09 % 10.1016/j.bmcl.2012.08.119
Rattus norvegicus Rattus norvegicus Inhibition 79.5 % 10.1021/jm049523y
Rattus norvegicus Rattus norvegicus Inhibition 79.5 % 10.1021/jm049939b
Rattus norvegicus Rattus norvegicus Inhibition 79.5 % 10.1021/jm0510474
Rattus norvegicus Rattus norvegicus Inhibition 79.59 % 10.1016/j.ejmech.2011.08.015
Rattus norvegicus Rattus norvegicus Inhibition 79.9 % 10.1021/jm0101287
Rattus norvegicus Rattus norvegicus Inhibition 79.9 % 10.1021/jm010153c
Rattus norvegicus Rattus norvegicus Inhibition 79.9 % 10.1021/jm0302391
Rattus norvegicus Rattus norvegicus Inhibition 79.99 % 10.1016/j.ejmech.2019.03.052
Rattus norvegicus Rattus norvegicus Inhibition 80.0 % 10.1016/j.bmcl.2014.09.024
Rattus norvegicus Rattus norvegicus Inhibition 81.17 % 10.1016/j.ejmech.2020.112662
Rattus norvegicus Rattus norvegicus Inhibition 82.0 % 10.1016/j.ejmech.2011.08.015
Rattus norvegicus Rattus norvegicus Inhibition 82.09 % 10.1016/j.bmcl.2006.11.035
Rattus norvegicus Rattus norvegicus Inhibition 82.2 % 10.1007/s00044-012-0130-y
Rattus norvegicus Rattus norvegicus Inhibition 82.6 % 10.1016/j.bmcl.2011.05.061
Rattus norvegicus Rattus norvegicus Inhibition 82.71 % 10.1016/j.ejmech.2020.112662
Rattus norvegicus Rattus norvegicus Inhibition 83.0 % 10.1016/j.bmc.2012.03.044
Rattus norvegicus Rattus norvegicus Inhibition 85.7 % 10.1016/j.bmcl.2011.05.061
Rattus norvegicus Rattus norvegicus Inhibition 86.7 % 10.1021/jm030765s
Rattus norvegicus Rattus norvegicus Inhibition 88.3 % 10.1016/j.ejmech.2020.112662
Rattus norvegicus Rattus norvegicus Inhibition 89.0 % 10.1016/j.bmcl.2018.01.043
Rattus norvegicus Rattus norvegicus Inhibition 89.0 % 10.1021/jm030765s
Rattus norvegicus Rattus norvegicus Inhibition 89.06 % 10.1016/j.bmc.2017.07.038
Rattus norvegicus Rattus norvegicus Inhibition 90.0 % 10.1021/jm701467e
Rattus norvegicus Rattus norvegicus Inhibition 92.17 % 10.1016/j.bmc.2015.07.070
Rattus norvegicus Rattus norvegicus Inhibition 93.4 % 10.1021/jm0009383
Rattus norvegicus Rattus norvegicus Inhibition 93.4 % 10.1021/jm030765s
Rattus norvegicus Rattus norvegicus Inhibition 94.0 % 10.1016/j.bmcl.2010.07.053
Rattus norvegicus Rattus norvegicus Inhibition 94.44 % 10.1016/j.ejmech.2014.02.033
Rattus norvegicus Rattus norvegicus Inhibition 100.0 % 10.1016/j.bmc.2015.07.070
Rattus norvegicus Rattus norvegicus Inhibition 100.0 % 10.1016/j.bmc.2017.07.038
Rattus norvegicus Rattus norvegicus Inhibition 100.0 % 10.1016/j.bmcl.2018.03.091
Rattus norvegicus Rattus norvegicus Inhibition 100.0 % 10.1016/j.ejmech.2014.02.033
Rattus norvegicus Rattus norvegicus Inhibition nan % 10.1016/j.bmcl.2006.06.032
Rattus norvegicus Rattus norvegicus Inhibition nan % 10.1016/j.ejmech.2014.05.012
Rattus norvegicus Rattus norvegicus LDH 107.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LDH 204.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LDH 234.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LDH 247.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LDH 271.5 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LDH 290.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LIPASE 6.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LIPASE 6.83 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LIPASE 7.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LIPASE 9.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LIPASE 10.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LIPASE 11.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYM 12879.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYM 14547.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYM 15009.33 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYM 15021.67 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYM 15747.67 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYM 17865.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYMLE 68.98 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYMLE 70.53 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYMLE 78.67 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYMLE 78.9 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYMLE 79.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYMLE 79.67 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYMLE 82.3 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYMLE 83.67 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYMLE 87.33 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYMLE 87.5 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCH 20.16 pg 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCH 20.4 pg 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCH 20.57 pg 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCH 21.27 pg 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCH 24.33 pg 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCH 24.67 pg 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCH 24.9 pg 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCH 25.05 pg 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCH 25.17 pg 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 311400.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 324300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 325300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 335300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 380700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 386300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 387300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 394000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 397300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 397800.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 62.6 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 62.8 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 62.87 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 62.97 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 63.27 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 63.38 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 63.47 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 63.93 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 64.4 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 64.7 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONO 292.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONO 360.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONO 376.5 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONO 523.67 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONO 604.33 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONO 640.67 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONOLE 1.83 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONOLE 1.9 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONOLE 2.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONOLE 2.2 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONOLE 2.33 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONOLE 2.54 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONOLE 3.27 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONOLE 3.33 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONOLE 3.67 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTLE 10.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTLE 13.9 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTLE 14.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTLE 15.67 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTLE 16.5 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTLE 16.67 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTLE 16.8 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTLE 24.33 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTLE 25.24 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTSG 1640.17 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTSG 1788.33 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTSG 2538.33 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTSG 2944.67 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTSG 3070.33 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTSG 3164.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NT nan None 10.1021/jm030765s
Rattus norvegicus Rattus norvegicus PHOS 106.5 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOS 115.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOS 116.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOS 118.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOS 122.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOS 124.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOS 125.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOS 126.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOS 127.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOS 129.4 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 1142670.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 1151670.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 1178330.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 1233670.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 1262670.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 1265670.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 1274500.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 1380330.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 1512200.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 1571330.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 5.29 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 5.89 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 5.95 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 6.08 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 6.11 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 6.28 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 6.47 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 6.63 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 6.73 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 7.1 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PROT 55000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PROT 55300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PROT 55500.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PROT 55700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PROT 56300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PROT 57200.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PROT 58000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PROT 59000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PROT 60700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBC 5240000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBC 5350000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBC 5490000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBC 5610000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBC 5760000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBC 5830000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBC 6610000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBC 6710000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBC 6920000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBC 6930000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBCNUC 0.0 /100WBC 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBCNUC 0.33 /100WBC 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus SODIUM 139.5 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus SODIUM 139.65 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus SODIUM 141.97 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus SODIUM 142.6 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus SODIUM 142.77 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus SODIUM 142.9 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus SODIUM 145.0 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus SODIUM 146.0 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus SODIUM 146.67 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus SODIUM 151.0 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus T1/2 3.5 hr 10.1021/jm1013693
Rattus norvegicus Rattus norvegicus T1/2 3.5 hr 10.1021/jm800219f
Rattus norvegicus Rattus norvegicus T1/2 3.5 hr 10.1021/jm960803q
Rattus norvegicus Rattus norvegicus T1/2 3.5 hr 10.1039/C2MD20317K
Rattus norvegicus Rattus norvegicus TIME 0.001597 hr 10.1016/j.ejmech.2019.111601
Rattus norvegicus Rattus norvegicus TIME 0.001761 hr 10.1016/j.ejmech.2019.111601
Rattus norvegicus Rattus norvegicus TIME 0.002322 hr 10.1016/j.ejmech.2019.111601
Rattus norvegicus Rattus norvegicus TIME 0.002481 hr 10.1016/j.ejmech.2019.111601
Rattus norvegicus Rattus norvegicus TIME 0.002561 hr 10.1016/j.ejmech.2019.111601
Rattus norvegicus Rattus norvegicus TIME 0.002633 hr 10.1016/j.ejmech.2019.111601
Rattus norvegicus Rattus norvegicus TIME 0.002756 hr 10.1016/j.ejmech.2019.111601
Rattus norvegicus Rattus norvegicus TIME 0.003019 hr 10.1016/j.ejmech.2019.111601
Rattus norvegicus Rattus norvegicus TIME 0.00305 hr 10.1016/j.ejmech.2019.111601
Rattus norvegicus Rattus norvegicus TIME 0.003206 hr 10.1016/j.ejmech.2019.111601
Rattus norvegicus Rattus norvegicus TIME 0.003356 hr 10.1016/j.ejmech.2019.111601
Rattus norvegicus Rattus norvegicus Tissue Severity Score nan None 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus Tmax 3.25 hr 10.1021/jm020563g
Rattus norvegicus Rattus norvegicus UD50 200.0 mg kg-1 10.1021/jm010484p
Rattus norvegicus Rattus norvegicus UI 0.0 None 10.1007/s00044-009-9203-y
Rattus norvegicus Rattus norvegicus UI 0.0 None 10.1039/C6MD00367B
Rattus norvegicus Rattus norvegicus UI 0.104 None 10.1016/j.bmcl.2006.11.035
Rattus norvegicus Rattus norvegicus UI 0.33 None 10.1016/j.bmcl.2017.08.023
Rattus norvegicus Rattus norvegicus UI 0.5 None 10.1016/j.ejmech.2014.03.001
Rattus norvegicus Rattus norvegicus UI 0.5 None 10.1016/j.ejmech.2014.06.049
Rattus norvegicus Rattus norvegicus UI 0.92 None 10.1016/j.ejmech.2014.04.065
Rattus norvegicus Rattus norvegicus UI 2.9 None 10.1016/j.bmcl.2015.11.105
Rattus norvegicus Rattus norvegicus UI 2.9 None 10.1016/j.ejmech.2016.04.049
Rattus norvegicus Rattus norvegicus UI 2.93 None 10.1016/j.ejmech.2020.112438
Rattus norvegicus Rattus norvegicus UI 2.99 None 10.1016/j.ejmech.2020.112438
Rattus norvegicus Rattus norvegicus UI 4.85 None 10.1016/j.bmcl.2015.10.047
Rattus norvegicus Rattus norvegicus UI 8.4 None 10.1007/s00044-011-9606-4
Rattus norvegicus Rattus norvegicus UI 9.58 None 10.1016/j.bmcl.2012.08.119
Rattus norvegicus Rattus norvegicus UI 11.13 None 10.1016/j.ejmech.2012.06.048
Rattus norvegicus Rattus norvegicus UI 11.9 None 10.1016/j.bmc.2015.07.070
Rattus norvegicus Rattus norvegicus UI 12.51 None 10.1007/s00044-013-0500-0
Rattus norvegicus Rattus norvegicus UI 12.51 None 10.1016/j.ejmech.2012.03.050
Rattus norvegicus Rattus norvegicus UI 16.12 None 10.1016/j.ejmech.2014.02.033
Rattus norvegicus Rattus norvegicus UI 44.4 None 10.1021/jm070821f
Rattus norvegicus Rattus norvegicus UI 49.4 None 10.1021/jm070821f
Rattus norvegicus Rattus norvegicus UI 53.0 None 10.1016/j.bmc.2017.06.027
Rattus norvegicus Rattus norvegicus UI 80.6 None 10.1021/jm070821f
Rattus norvegicus Rattus norvegicus UI 120.0 None 10.1007/s00044-012-9975-3
Rattus norvegicus Rattus norvegicus Ulceration 0.0 % 10.1021/jm960803q
Rattus norvegicus Rattus norvegicus Ulcer score 0.0 None 10.1021/jm991106b
Rattus norvegicus Rattus norvegicus URATE 11.2 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus URATE 12.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus URATE 13.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus URATE 16.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus URATE 17.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WBC 11060.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WBC 12220.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WBC 12560.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WBC 16300.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WBC 16580.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WBC 18000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WBC 18190.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WBC 18800.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WBC 19070.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WBC 21330.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Serotonin 1a (5-HT1a) receptor IC50 nan None None
Rattus norvegicus Serotonin 1a (5-HT1a) receptor Ki nan None None
Rattus norvegicus Serotonin 1b (5-HT1b) receptor IC50 nan None None
Rattus norvegicus Serotonin 1b (5-HT1b) receptor Ki nan None None
Rattus norvegicus Voltage-gated L-type calcium channel alpha-1C subunit AC50 10000.0 nM 10.1038/s41467-023-40064-9
Rattus norvegicus Voltage-gated N-type calcium channel alpha-1B subunit AC50 10000.0 nM 10.1038/s41467-023-40064-9
Saccharomyces cerevisiae S288c Carbonic anhydrase Ki 108.0 nM 10.1016/j.bmc.2008.12.035
Salmonella enterica subsp. enterica serovar Typhimurium Salmonella typhimurium Activity nan None 10.1128/aac.00048-09
Severe acute respiratory syndrome coronavirus 2 Replicase polyprotein 1ab Inhibition -1.37 % 10.6019/CHEMBL4495564
Severe acute respiratory syndrome coronavirus 2 Replicase polyprotein 1ab Inhibition 3.985 % 10.6019/CHEMBL4495564
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Hit score 0.04185 None 10.1101/2020.04.21.054387
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 IC50 19952.62 nM 10.6019/CHEMBL4651402
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 IC50 20000.0 nM 10.6019/CHEMBL4651402
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Inhibition 0.61 % 10.6019/CHEMBL4495565
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Inhibition 5.49 % 10.6019/CHEMBL4495565
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Inhibition 31.66 % 10.21203/rs.3.rs-23951/v1
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Inhibition index -0.3372 None 10.1101/2020.04.03.023846
Staphylococcus aureus Quinolone resistance protein norA IC50 40000.0 nM 10.1021/jm201446h
Staphylococcus aureus Quinolone resistance protein norA Inhibition 64.5 % 10.1021/jm201446h
Staphylococcus aureus Quinolone resistance protein norA Inhibition nan % 10.1021/jm201446h
Staphylococcus aureus Staphylococcus aureus FC 6.0 None 10.1016/j.bmc.2012.06.018
Staphylococcus aureus Staphylococcus aureus Inhibition 5.39 % 10.6019/CHEMBL4513141
Staphylococcus aureus Staphylococcus aureus MIC 32.0 ug.mL-1 10.1016/j.bmc.2012.06.018
Staphylococcus aureus Staphylococcus aureus MIC 100.0 ug.mL-1 10.1021/jm201446h
Staphylococcus aureus Staphylococcus aureus MIC 100000.0 nM 10.1128/aac.00735-10
Staphylococcus aureus Staphylococcus aureus MIC nan None 10.1021/jm201446h
Staphylococcus epidermidis Staphylococcus epidermidis MIC 16.0 ug.mL-1 10.1016/j.bmc.2012.06.018
Stylophora pistillata Alpha carbonic anhydrase Ki 34.2 nM 10.1016/j.bmc.2009.05.063
Stylophora pistillata Alpha carbonic anhydrase Ki 34.2 nM 10.1016/j.bmcl.2010.11.124
Stylophora pistillata Carbonic anhydrase Ki 690.0 nM 10.1016/j.bmcl.2010.11.124
Sulfurihydrogenibium sp. (strain YO3AOP1) Carbonate dehydratase Ki 6.9 nM 10.1016/j.bmcl.2015.11.104
Thalassiosira weissflogii Delta carbonic anhydrase Ki 265.0 nM 10.1016/j.bmcl.2013.11.021
Thiomicrospira crunogena (strain XCL-2) Carbonic anhydrase, alpha family Ki 981.0 nM 10.1016/j.bmcl.2015.11.104
Trypanosoma cruzi Cruzipain IC50 126000.0 nM 10.1021/jm100254w
Trypanosoma cruzi Cruzipain IC50 400000.0 nM 10.1021/jm100254w
Trypanosoma cruzi Cruzipain Potency 39810.7 nM None
None ADMET Activity 0.0 % 10.1016/j.ejmech.2019.03.042
None ADMET Activity 0.0 None 10.1016/j.ejmech.2019.03.042
None ADMET Activity 0.0 None 10.1016/j.ejmech.2020.112066
None ADMET Activity 0.4 None 10.1016/j.bmcl.2016.04.046
None ADMET Activity 0.5 None 10.1016/j.bmcl.2016.04.046
None ADMET Activity 0.6 None 10.1039/C9MD00228F
None ADMET Activity 2.0 % 10.1016/j.bmcl.2016.04.046
None ADMET Activity 2.0 % 10.1039/C9MD00228F
None ADMET Activity nan None 10.1016/j.ejmech.2020.112662
None ADMET Activity nan None 10.1039/C9MD00228F
None ADMET Activity_index 0.92 None 10.1016/j.bmcl.2020.127743
None ADMET AUC 6600.0 ng.hr.mL-1 10.1021/acs.jmedchem.1c00880
None ADMET Biotransformation nan None 10.1038/s41586-019-1291-3
None ADMET CL 10.5 mL.min-1.kg-1 10.1021/acs.jmedchem.1c00890
None ADMET CL 25.7 uL.min-1.(10^6cells)-1 10.6019/CHEMBL3301361
None ADMET CL nan None 10.1124/dmd.111.039180
None ADMET Cmax 3146.47 nM 10.1021/acs.jmedchem.1c00880
None ADMET Cp 2150.0 ng/ml 10.1021/acs.jmedchem.1c00890
None ADMET Cp 2553.0 ng/ml 10.1021/acs.jmedchem.1c00890
None ADMET Ct 9460.0 ng/g 10.1021/acs.jmedchem.1c00890
None ADMET EC50 50000.0 nM 10.1016/j.bmc.2014.02.032
None ADMET Fu 0.003 None 10.1021/acs.jmedchem.1c00890
None ADMET Fu 0.0031 None 10.1021/acs.jmedchem.1c00890
None ADMET Gastric score 0.7 None 10.1021/jm990965x
None ADMET IC50 95260.0 nM 10.1016/j.bmcl.2016.06.037
None ADMET IC50 98150.0 nM 10.1016/j.bmcl.2016.06.037
None ADMET Inhibition 51.11 % 10.1016/j.ejmech.2019.03.052
None ADMET Inhibition 92.0 % 10.1021/jm100398z
None ADMET Papp 22.4 10^-6 cm/s 10.1021/acs.jmedchem.1c00890
None ADMET PPB 98.94 % 10.6019/CHEMBL3301361
None ADMET Ratio 0.1 None 10.1016/j.bmcl.2009.02.085
None ADMET Ratio 0.71 None 10.1016/j.bmc.2014.02.032
None ADMET Ratio 3.8 None 10.1021/acs.jmedchem.1c00890
None ADMET Ratio 4.6 None 10.1021/acs.jmedchem.1c00890
None ADMET T1/2 0.5517 hr 10.1021/acs.jmedchem.1c00890
None ADMET T1/2 0.9567 hr 10.1021/acs.jmedchem.1c00890
None ADMET T1/2 0.9883 hr 10.1021/acs.jmedchem.1c00890
None ADMET T1/2 1.12 hr 10.1021/acs.jmedchem.1c00890
None ADMET T1/2 1.27 hr 10.1021/acs.jmedchem.1c00890
None ADMET T1/2 3.5 hr 10.1016/j.bmcl.2018.09.016
None ADMET T1/2 5.2 hr 10.1021/acs.jmedchem.1c00880
None ADMET T1/2 12.0 hr 10.1016/j.bmcl.2018.09.016
None ADMET TIME 8.0 hr 10.1016/j.bmcl.2016.08.023
None ADMET Tmax 0.25 hr 10.1021/acs.jmedchem.1c00890
None ADMET Tmax 0.28 hr 10.1021/acs.jmedchem.1c00880
None ADMET UI 2.7 None 10.1016/j.ejmech.2019.03.036
None ADMET UI 2.9 None 10.1016/j.bmcl.2016.04.046
None ADMET UI 3.0 None 10.1016/j.ejmech.2019.03.042
None ADMET UI 3.2 None 10.1039/C9MD00228F
None ADMET UI 6.2 None 10.1016/j.ejmech.2019.03.036
None ADMET Vdss 0.94 L.kg-1 10.1021/acs.jmedchem.1c00890
None Hepatotoxicity Hepatotoxicity nan None 10.1021/tx900326k
None Hepatotoxicity Hepatotoxicity nan None 10.1124/dmd.110.035113
None Hepatotoxicity HepSE_bilirubinemia 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_cholecystitis 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_cholelithiasis 1.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_cirrhosis 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_Combined Scores 5.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_elevated liver function tests 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_hepatic failure 1.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_hepatic necrosis 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_hepatitis 1.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_hepatomegaly 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_jaundice 1.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_liver disease 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_liver fatty 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_liver function tests abnormal 1.0 None 10.1371/journal.pcbi.1002310
None Molecular identity unknown Potency 5623.4 nM None
None Molecular identity unknown Potency 74978.0 nM None
None NON-PROTEIN TARGET Activity 1.91 ml None
None NON-PROTEIN TARGET Activity 6.3 U/ml 10.1016/j.bmcl.2016.09.060
None NON-PROTEIN TARGET Activity 7.3 nmol/ml 10.1016/j.bmcl.2016.09.060
None NON-PROTEIN TARGET Activity 8.0 % None
None NON-PROTEIN TARGET Activity 8.9 % None
None NON-PROTEIN TARGET Activity 9.8 % None
None NON-PROTEIN TARGET Activity 16.7 % None
None NON-PROTEIN TARGET Activity 17.3 % None
None NON-PROTEIN TARGET Activity 48.3 g None
None NON-PROTEIN TARGET Activity 52.9 g None
None NON-PROTEIN TARGET Activity 61.6 ng/L 10.1016/j.bmcl.2016.09.060
None NON-PROTEIN TARGET Activity 78.0 U/ml 10.1016/j.bmcl.2016.09.060
None NON-PROTEIN TARGET Activity 135.3 ng/L 10.1016/j.bmcl.2016.09.060
None NON-PROTEIN TARGET Activity nan None 10.1016/j.bmcl.2016.09.034
None NON-PROTEIN TARGET Activity nan None 10.1016/j.ejmech.2011.10.018
None NON-PROTEIN TARGET Activity nan None 10.1128/aac.00048-09
None NON-PROTEIN TARGET ED50 38.5 mg.kg-1 None
None NON-PROTEIN TARGET ED50 154.0 mg.kg-1 None
None NON-PROTEIN TARGET GI nan None 10.1016/j.bmc.2013.02.033
None NON-PROTEIN TARGET GI50 17500.0 nM 10.1021/jm1001327
None NON-PROTEIN TARGET Hepatotoxicity (acute) 0.0 % 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (animal toxicity known) nan None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (benign tumour) 0.0 None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (granulomatous hepatitis) 0.0 None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (mechanism) nan None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (moderate) 2.0 % 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (moderate) 3.0 None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (time to onset) nan None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET IC50 750.0 nM 10.1016/j.bmcl.2013.11.015
None NON-PROTEIN TARGET IC50 1300.0 nM 10.1016/j.bmcl.2013.11.015
None NON-PROTEIN TARGET IC50 2000.0 nM 10.1016/j.bmc.2013.02.033
None NON-PROTEIN TARGET IC50 4200.0 nM 10.1016/j.bmc.2013.02.033
None NON-PROTEIN TARGET IC50 4560.0 nM 10.1016/j.bmcl.2015.03.022
None NON-PROTEIN TARGET IC50 4900.0 nM 10.1016/j.bmcl.2013.11.015
None NON-PROTEIN TARGET IC50 13400.0 nM 10.1016/j.bmcl.2013.11.015
None NON-PROTEIN TARGET IC50 14360.0 nM 10.1016/j.bmcl.2016.06.037
None NON-PROTEIN TARGET IC50 32600.0 nM 10.1016/j.bmc.2016.12.032
None NON-PROTEIN TARGET IC50 500000.0 nM 10.1016/j.bmc.2008.11.074
None NON-PROTEIN TARGET IC50 nan None 10.1016/j.bmc.2016.12.032
None NON-PROTEIN TARGET Inhibition 20.1 % 10.1039/C5MD00171D
None NON-PROTEIN TARGET Inhibition 27.0 % 10.1016/j.bmc.2008.11.074
None NON-PROTEIN TARGET Inhibition 27.0 % 10.1016/j.ejmech.2007.09.007
None NON-PROTEIN TARGET Inhibition 31.1 % 10.1039/C5MD00171D
None NON-PROTEIN TARGET Inhibition 37.4 % 10.1039/C5MD00171D
None NON-PROTEIN TARGET Inhibition nan % 10.1016/j.bmcl.2016.09.060
None NON-PROTEIN TARGET LC50 63300.0 nM 10.1021/jm1001327
None NON-PROTEIN TARGET MIC 16.0 ug.mL-1 10.1128/aac.00048-09
None NON-PROTEIN TARGET MIC 32.0 ug.mL-1 10.1128/aac.00048-09
None NON-PROTEIN TARGET Potency 9432.9 nM None
None NON-PROTEIN TARGET Potency 10583.9 nM None
None NON-PROTEIN TARGET Potency 11875.4 nM None
None NON-PROTEIN TARGET Potency 60537.8 nM None
None No relevant target Activity 80.29 % 10.1016/j.ejmech.2018.11.027
None No relevant target Activity 120.0 uM 10.1021/jm100254w
None No relevant target Activity 161.8 nm 10.1021/jm100254w
None No relevant target EC50 90000.0 nM 10.1016/j.bmc.2011.04.050
None No relevant target IC50 1970000.0 nM 10.1016/j.ejmech.2018.07.007
None No relevant target IC50 1990000.0 nM 10.1016/j.ejmech.2018.07.007
None No relevant target LogD7.4 3.42 None 10.6019/CHEMBL3301361
None No relevant target LogP 3.01 None 10.1021/jm020563g
None No relevant target LogP 3.9 None 10.1016/j.ejmech.2009.12.043
None No relevant target pKa 14.16 None 10.1124/dmd.112.050278
None No relevant target solubility nan None 10.1016/j.bmc.2021.116344
None No relevant target Solubility 2200.0 nM 10.6019/CHEMBL3301361
None No relevant target Solubility 133500.0 nM 10.1021/acs.jmedchem.1c00890
None Unchecked Ac50 11.22 uM None
None Unchecked Ac50 15.85 uM None
None Unchecked Ac50 35.48 uM None
None Unchecked Ac50 39.81 uM None
None Unchecked Ac50 44.67 uM None
None Unchecked AC50 11230.0 nM None
None Unchecked AC50 15848.9 nM None
None Unchecked AC50 35481.3 nM None
None Unchecked AC50 39810.7 nM None
None Unchecked AC50 44668.4 nM None
None Unchecked Activity 0.18 pg/ml 10.1016/j.bmcl.2011.08.050
None Unchecked Activity 0.81 pg/ml 10.1016/j.bmcl.2011.08.050
None Unchecked Activity 2.87 pg/ml 10.1016/j.bmcl.2011.08.050
None Unchecked Activity nan None 10.1016/j.bmc.2022.116633
None Unchecked Activity nan None 10.1016/j.bmcl.2013.11.015
None Unchecked EC50 1.15 nM 10.1016/j.bmcl.2012.03.013
None Unchecked ED50 10.0 mg.kg-1 10.1021/jm990965x
None Unchecked ED50 40.0 mg.kg-1 10.1021/jm990965x
None Unchecked FICI 0.0665 None 10.1128/aac.00735-10
None Unchecked FICI 0.1875 None 10.1128/aac.00735-10
None Unchecked FICI 0.2812 None 10.1128/aac.00735-10
None Unchecked FICI 0.3125 None 10.1128/aac.00735-10
None Unchecked FICI 0.5312 None 10.1128/aac.00735-10
None Unchecked FICI 0.5625 None 10.1128/aac.00735-10
None Unchecked GI nan None 10.1016/j.bmc.2013.02.033
None Unchecked Hepatotoxicity (acute) 8.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (association with vascular disease) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (choleostasis) 4.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (chronic liver disease) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (cirrhosis) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (comment) nan None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (cytolytic) 5.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (malignant tumour) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (severe hepatitis) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (steatosis) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (successful reintroduction) nan None 10.1016/s0399-8320(04)95062-2
None Unchecked IC50 7.9 nM 10.1021/jm9906015
None Unchecked IC50 112.0 nM 10.1016/j.ejmech.2017.09.056
None Unchecked IC50 6000.0 nM 10.1016/j.bmc.2013.02.033
None Unchecked IC50 9260.0 nM None
None Unchecked IC50 10000.0 nM 10.1016/j.bmc.2011.01.043
None Unchecked IC50 10000.0 nM 10.1016/j.bmcl.2008.10.009
None Unchecked IC50 10000.0 nM 10.1016/j.bmcl.2009.12.047
None Unchecked IC50 16854.0 nM None
None Unchecked IC50 17500.0 nM 10.1016/j.bmc.2013.02.033
None Unchecked IC50 18300.0 nM 10.1016/j.bmc.2013.02.033
None Unchecked IC50 24601.0 nM None
None Unchecked IC50 32000.0 nM 10.1021/acs.jmedchem.9b01509
None Unchecked IC50 55600.0 nM 10.1016/j.ejmech.2021.113621
None Unchecked IC50 73400.0 nM 10.1016/j.bmcl.2009.10.069
None Unchecked IC50 nan None 10.1016/j.bmc.2017.06.027
None Unchecked IC50 nan None 10.1016/j.bmcl.2016.04.046
None Unchecked IC50 nan None 10.1016/j.ejmech.2016.04.049
None Unchecked IC50 nan None 10.1016/j.ejmech.2016.08.013
None Unchecked IC50 nan None 10.1016/j.ejmech.2019.07.004
None Unchecked IC50 nan None 10.1016/j.ejmech.2022.114597
None Unchecked IC50 nan None None
None Unchecked Inhibition 5.7 % 10.1016/j.bmcl.2012.03.013
None Unchecked Inhibition 17.0 % 10.1016/j.bmc.2008.04.066
None Unchecked Inhibition nan % 10.1128/aac.00735-10
None Unchecked Ki 6.9 nM 10.1016/j.bmc.2012.07.024
None Unchecked Ki 18.0 nM 10.1016/j.bmc.2010.12.048
None Unchecked Ki 87.6 nM 10.1016/j.bmc.2015.02.045
None Unchecked Ki 87.6 nM 10.1016/j.bmcl.2015.06.079
None Unchecked Ki 87.6 nM 10.1016/j.bmcl.2016.01.023
None Unchecked Ki 91.1 nM 10.1021/jm4000616
None Unchecked Ki 128.0 nM 10.1016/j.bmc.2010.12.048
None Unchecked Ki 140.0 nM 10.1016/j.bmc.2015.02.045
None Unchecked Ki 140.0 nM 10.1016/j.bmcl.2013.11.030
None Unchecked Ki 140.0 nM 10.1016/j.bmcl.2015.06.079
None Unchecked Ki 169.0 nM 10.1016/j.bmc.2014.07.048
None Unchecked Ki 169.0 nM 10.1016/j.bmc.2015.02.045
None Unchecked Ki 169.0 nM 10.1016/j.bmcl.2013.11.021
None Unchecked Ki 169.0 nM 10.1016/j.bmcl.2013.11.030
None Unchecked Ki 169.0 nM 10.1016/j.bmcl.2016.01.023
None Unchecked Ki 217.0 nM 10.1016/j.bmc.2014.12.009
None Unchecked Ki 369.0 nM 10.1016/j.bmc.2012.02.029
None Unchecked Ki 402.0 nM 10.1016/j.bmcl.2016.01.023
None Unchecked Ki 421.0 nM 10.1016/j.bmc.2014.04.006
None Unchecked Ki 705.0 nM 10.1016/j.bmcl.2013.11.021
None Unchecked Ki 705.0 nM 10.1021/jm400939k
None Unchecked Ki 761.0 nM 10.1016/j.bmcl.2015.06.079
None Unchecked Ki 761.0 nM 10.1016/j.bmcl.2016.01.023
None Unchecked Ki 788.0 nM 10.1016/j.bmcl.2016.02.032
None Unchecked Ki 834.0 nM 10.1016/j.bmcl.2016.03.014
None Unchecked Ki 834.0 nM 10.1016/j.bmcl.2016.12.035
None Unchecked Ki 866.0 nM 10.1016/j.bmcl.2015.10.074
None Unchecked Ki 990.0 nM 10.1016/j.bmc.2014.04.006
None Unchecked Ki 1000.0 nM 10.1021/jm301611m
None Unchecked Ki 2425.0 nM 10.1016/j.bmcl.2015.04.037
None Unchecked Ki 3056.0 nM 10.1016/j.bmc.2009.05.002
None Unchecked Ki 4150.0 nM 10.1016/j.bmc.2014.07.048
None Unchecked Ki 4165.0 nM 10.1016/j.bmc.2016.01.037
None Unchecked Ki 4165.0 nM 10.1016/j.bmcl.2016.02.032
None Unchecked Ki 5830.0 nM 10.1016/j.bmc.2011.06.038
None Unchecked Ki 6110.0 nM 10.1016/j.bmc.2011.06.038
None Unchecked Ki 7015.0 nM 10.1016/j.bmc.2017.05.007
None Unchecked Ki 7760.0 nM 10.1021/jm9003126
None Unchecked Ki 8380.0 nM 10.1016/j.bmcl.2016.07.060
None Unchecked Ki 10000.0 nM 10.1016/j.bmc.2016.01.037
None Unchecked Ki 10350.0 nM 10.1021/jm9000488
None Unchecked Ki 15111.0 nM None
None Unchecked Ki 15815.0 nM None
None Unchecked Ki 34800.0 nM 10.1021/jm300203r
None Unchecked Ki 50000.0 nM 10.1016/j.bmc.2017.05.007
None Unchecked Ki 50000.0 nM 10.1016/j.bmcl.2016.12.035
None Unchecked Ki 52300.0 nM 10.1016/j.bmc.2010.06.056
None Unchecked Ki nan None 10.1016/j.bmc.2012.07.024
None Unchecked Ki nan None 10.1016/j.bmc.2014.04.006
None Unchecked Ki nan None 10.1016/j.bmc.2014.07.048
None Unchecked Ki nan None 10.1016/j.bmcl.2015.10.074
None Unchecked Ki nan None None
None Unchecked Potency 303.4 nM None
None Unchecked Potency 10000.0 nM None
None Unchecked Potency 11220.2 nM None
None Unchecked Potency 15848.9 nM None
None Unchecked Potency 24100.5 nM None
None Unchecked Potency 27041.2 nM None
None Unchecked Potency 29092.9 nM None
None Unchecked Potency 38196.8 nM None
None Unchecked Potency 42163.2 nM None
None Unchecked Potency 42857.5 nM None
None Unchecked Potency 43232.4 nM None
None Unchecked Potency 48086.9 nM None
None Unchecked Potency 53954.4 nM None
None Unchecked Potency 85511.9 nM None
None Unchecked Ratio 0.5 None 10.1128/aac.00048-09
None Unchecked Ratio 0.6 None 10.1016/j.bmc.2012.06.018
None Unchecked Ratio 3.03 None 10.1016/j.bmcl.2004.12.009
None Unchecked Ratio 6.2 None 10.1016/j.bmcl.2003.10.004
None Unchecked Ratio 6.3 None 10.1016/s0960-894x(99)00288-7
None Unchecked Ratio 295.0 None 10.1016/j.bmc.2021.116344
None Unchecked Ratio IC50 0.0018 None 10.1016/j.bmc.2007.06.030
None Unchecked Ratio IC50 0.0028 None 10.1016/j.bmc.2017.09.035
None Unchecked Ratio IC50 0.0028 None 10.1016/j.bmcl.2012.08.082
None Unchecked Ratio IC50 0.0028 None 10.1016/j.bmcl.2014.03.087
None Unchecked Ratio IC50 0.0028 None 10.1016/j.ejmech.2012.01.032
None Unchecked Ratio IC50 0.0083 None 10.1016/j.bmc.2022.116633
None Unchecked Ratio IC50 0.017 None 10.1016/j.ejmech.2015.11.013
None Unchecked Ratio IC50 0.02 None 10.1007/s00044-013-0500-0
None Unchecked Ratio IC50 0.02 None 10.1016/j.bmc.2016.11.037
None Unchecked Ratio IC50 0.02 None 10.1016/j.ejmech.2012.03.050
None Unchecked Ratio IC50 0.04 None 10.1016/j.bmcl.2015.12.088
None Unchecked Ratio IC50 0.06 None 10.1016/j.bmc.2010.04.034
None Unchecked Ratio IC50 1.8 None 10.1016/j.bmc.2017.08.029
None Unchecked Ratio IC50 3.23 None 10.1039/d1md00280e
None Unchecked Ratio IC50 3.52 None 10.1039/d1md00280e
None Unchecked Ratio IC50 3.71 None 10.1016/j.ejmech.2019.03.052
None Unchecked Ratio IC50 4.0 None 10.1016/j.bmcl.2009.02.085
None Unchecked Ratio IC50 4.92 None 10.1016/j.ejmech.2016.08.013
None Unchecked Ratio IC50 4.93 None 10.1016/j.bmcl.2016.04.046
None Unchecked Ratio IC50 4.93 None 10.1016/j.ejmech.2016.04.049
None Unchecked Ratio IC50 6.44 None 10.1016/j.ejmech.2020.112662
None Unchecked Ratio IC50 6.61 None 10.1039/d2md00192f
None Unchecked Ratio IC50 6.75 None 10.1016/j.bmcl.2017.08.023
None Unchecked Ratio IC50 7.0 None 10.1016/j.bmcl.2013.11.015
None Unchecked Ratio IC50 7.0 None 10.1021/acs.jmedchem.1c00890
None Unchecked Ratio IC50 7.2 None 10.1016/j.ejmech.2016.12.030
None Unchecked Ratio IC50 7.46 None 10.1021/jm049480l
None Unchecked Ratio IC50 7.46 None 10.1021/jm900702b
None Unchecked Ratio IC50 7.6 None 10.1016/j.bmcl.2015.10.047
None Unchecked Ratio IC50 7.64 None 10.1016/j.bmc.2013.01.058
None Unchecked Ratio IC50 7.7 None 10.1016/j.bmcl.2015.11.105
None Unchecked Ratio IC50 8.177 None 10.1039/C9MD00228F
None Unchecked Ratio IC50 8.31 None 10.1016/j.ejmech.2016.11.006
None Unchecked Ratio IC50 9.7 None 10.1016/j.bmcl.2017.06.002
None Unchecked Ratio IC50 10.0 None 10.1016/j.bmc.2008.11.074
None Unchecked Ratio IC50 10.0 None 10.1016/j.ejmech.2007.12.017
None Unchecked Ratio IC50 10.3 None 10.1016/j.bmcl.2013.11.015
None Unchecked Ratio IC50 11.3 None 10.1016/j.bmcl.2009.10.069
None Unchecked Ratio IC50 11.7 None 10.1021/jm0611861
None Unchecked Ratio IC50 11.88 None 10.1016/j.bmc.2018.07.024
None Unchecked Ratio IC50 14.0 None 10.1016/j.bmcl.2014.02.074
None Unchecked Ratio IC50 15.17 None 10.1016/j.ejmech.2021.113682
None Unchecked Ratio IC50 16.0 None 10.1016/j.bmcl.2009.02.085
None Unchecked Ratio IC50 17.18 None 10.1016/j.ejmech.2019.03.036
None Unchecked Ratio IC50 19.7 None 10.1016/j.bmcl.2020.127376
None Unchecked Ratio IC50 22.7 None 10.1021/jm300049g
None Unchecked Ratio IC50 23.0 None 10.1021/jm0707525
None Unchecked Ratio IC50 23.0 None 10.1021/jm200715n
None Unchecked Ratio IC50 23.0 None 10.1021/jm800084s
None Unchecked Ratio IC50 23.0 None 10.1021/jm901269y
None Unchecked Ratio IC50 27.86 None 10.1016/j.bmcl.2019.05.051
None Unchecked Ratio IC50 29.6 None 10.1016/j.bmc.2008.07.058
None Unchecked Ratio IC50 30.0 None 10.1016/j.bmc.2013.04.031
None Unchecked Ratio IC50 30.0 None 10.1016/j.bmcl.2009.02.085
None Unchecked Ratio IC50 37.0 None 10.1021/acs.jmedchem.1c00890
None Unchecked Ratio IC50 39.67 None 10.1016/j.bmcl.2016.12.069
None Unchecked Ratio IC50 40.0 None 10.1016/j.ejmech.2019.07.004
None Unchecked Ratio IC50 41.33 None 10.1016/j.bmc.2018.01.007
None Unchecked Ratio IC50 50.0 None 10.1016/j.bmc.2013.04.074
None Unchecked Ratio IC50 53.12 None 10.1016/j.ejmech.2020.112066
None Unchecked Ratio IC50 60.0 None 10.1016/j.bmc.2008.01.047
None Unchecked Ratio IC50 61.7 None 10.1016/j.bmc.2008.07.058
None Unchecked Ratio IC50 61.7 None 10.1021/jm0707525
None Unchecked Ratio IC50 62.9 None 10.1016/j.bmc.2013.04.031
None Unchecked Ratio IC50 63.0 None 10.1016/j.ejmech.2022.114615
None Unchecked Ratio IC50 63.0 None 10.1021/jm200715n
None Unchecked Ratio IC50 64.2 None 10.1016/j.bmcl.2010.01.014
None Unchecked Ratio IC50 65.0 None 10.1016/j.bmc.2018.06.038
None Unchecked Ratio IC50 65.0 None 10.1021/jm901269y
None Unchecked Ratio IC50 69.0 None 10.1021/jm100398z
None Unchecked Ratio IC50 76.39 None 10.1016/j.ejmech.2019.07.016
None Unchecked Ratio IC50 78.0 None 10.1016/j.bmc.2007.11.033
None Unchecked Ratio IC50 80.43 None 10.1016/j.ejmech.2013.10.032
None Unchecked Ratio IC50 88.0 None 10.1016/j.bmcl.2017.07.020
None Unchecked Ratio IC50 92.87 None 10.1016/j.ejmech.2019.111601
None Unchecked Ratio IC50 92.87 None 10.1021/ml400500e
None Unchecked Ratio IC50 93.4 None 10.1016/j.bmcl.2020.127173
None Unchecked Ratio IC50 97.88 None 10.1016/j.ejmech.2019.03.008
None Unchecked Ratio IC50 100.0 None 10.1016/j.bmc.2012.09.021
None Unchecked Ratio IC50 106.66 None 10.1016/j.bmcl.2014.08.062
None Unchecked Ratio IC50 110.0 None 10.1016/j.bmc.2008.12.032
None Unchecked Ratio IC50 110.0 None 10.1016/j.bmc.2009.05.046
None Unchecked Ratio IC50 110.0 None 10.1016/j.bmcl.2011.08.053
None Unchecked Ratio IC50 110.0 None 10.1016/j.bmcl.2012.01.130
None Unchecked Ratio IC50 110.0 None 10.1016/j.bmcl.2012.10.131
None Unchecked Ratio IC50 111.32 None 10.1016/j.ejmech.2019.111780
None Unchecked Ratio IC50 126.58 None 10.1021/acs.jnatprod.2c01153
None Unchecked Ratio IC50 130.25 None 10.1016/j.bmc.2018.07.022
None Unchecked Ratio IC50 139.9 None 10.1016/j.bmcl.2016.06.037
None Unchecked Ratio IC50 160.0 None 10.1016/j.bmc.2011.01.043
None Unchecked Ratio IC50 178.0 None 10.1016/j.bmc.2015.10.007
None Unchecked Ratio IC50 178.57 None 10.1016/j.bmc.2012.03.044
None Unchecked Ratio IC50 178.57 None 10.1016/j.ejmech.2014.02.033
None Unchecked Ratio IC50 178.6 None 10.1016/j.ejmech.2014.01.063
None Unchecked Ratio IC50 178.6 None 10.1016/j.ejmech.2014.08.048
None Unchecked Ratio IC50 200.0 None 10.1016/j.bmc.2013.05.029
None Unchecked Ratio IC50 200.0 None 10.1016/j.bmc.2014.02.042
None Unchecked Ratio IC50 200.0 None 10.1016/j.ejmech.2014.04.033
None Unchecked Ratio IC50 227.27 None 10.1016/j.ejmech.2018.09.007
None Unchecked Ratio IC50 269.0 None 10.1016/j.ejmech.2019.111863
None Unchecked Ratio IC50 277.77 None 10.1039/C6MD00367B
None Unchecked Ratio IC50 294.0 None 10.1016/j.ejmech.2020.112439
None Unchecked Ratio IC50 296.0 None 10.1016/j.bmc.2017.08.039
None Unchecked Ratio IC50 296.0 None 10.1016/j.ejmech.2017.12.065
None Unchecked Ratio IC50 296.0 None 10.1016/j.ejmech.2019.02.012
None Unchecked Ratio IC50 296.0 None 10.1016/j.ejmech.2019.02.034
None Unchecked Ratio IC50 296.0 None 10.1016/j.ejmech.2019.03.042
None Unchecked Ratio IC50 300.0 None 10.1016/j.bmc.2016.09.023
None Unchecked Ratio IC50 303.3 None 10.1016/j.ejmech.2016.05.066
None Unchecked Ratio IC50 308.16 None 10.1016/j.ejmech.2019.111693
None Unchecked Ratio IC50 313.0 None 10.1016/j.bmcl.2011.01.057
None Unchecked Ratio IC50 326.6 None 10.1016/j.ejmech.2021.113457
None Unchecked Ratio IC50 326.67 None 10.1016/j.bmc.2020.115403
None Unchecked Ratio IC50 333.0 None 10.1016/j.ejmech.2007.03.030
None Unchecked Ratio IC50 333.0 None 10.1016/j.ejmech.2010.10.001
None Unchecked Ratio IC50 333.3 None 10.1016/j.bmc.2016.03.032
None Unchecked Ratio IC50 333.3 None 10.1016/j.bmc.2016.06.026
None Unchecked Ratio IC50 333.3 None 10.1016/j.ejmech.2011.02.013
None Unchecked Ratio IC50 333.33 None 10.1016/j.ejmech.2016.03.011
None Unchecked Ratio IC50 350.0 None 10.1016/j.bmcl.2016.08.034
None Unchecked Ratio IC50 357.0 None 10.1016/j.ejmech.2014.04.045
None Unchecked Ratio IC50 375.0 None 10.1016/j.bmc.2014.05.059
None Unchecked Ratio IC50 375.0 None 10.1016/j.bmc.2019.115246
None Unchecked Ratio IC50 375.0 None 10.1016/j.bmcl.2013.11.080
None Unchecked Ratio IC50 375.0 None 10.1016/j.bmcl.2016.02.029
None Unchecked Ratio IC50 375.0 None 10.1016/j.ejmech.2014.01.030
None Unchecked Ratio IC50 375.0 None 10.1016/j.ejmech.2014.03.003
None Unchecked Ratio IC50 375.0 None 10.1016/j.ejmech.2015.04.044
None Unchecked Ratio IC50 375.0 None 10.1021/acs.jmedchem.1c00880
None Unchecked Ratio IC50 375.0 None 10.1021/acs.jmedchem.6b00134
None Unchecked Ratio IC50 375.0 None 10.1021/acs.jmedchem.8b00922
None Unchecked Ratio IC50 375.0 None 10.1021/acs.jmedchem.9b00823
None Unchecked Ratio IC50 384.6 None 10.1016/j.bmcl.2013.02.107
None Unchecked Ratio IC50 384.6 None 10.1016/j.ejmech.2014.12.039
None Unchecked Ratio IC50 403.0 None 10.1007/s00044-009-9230-8
None Unchecked Ratio IC50 403.0 None 10.1007/s00044-012-0244-2
None Unchecked Ratio IC50 403.0 None 10.1016/j.bmcl.2007.07.084
None Unchecked Ratio IC50 405.0 None 10.1007/s00044-011-9709-y
None Unchecked Ratio IC50 405.0 None 10.1007/s00044-011-9710-5
None Unchecked Ratio IC50 405.0 None 10.1007/s00044-012-0387-1
None Unchecked Ratio IC50 405.0 None 10.1016/j.bmc.2009.05.084
None Unchecked Ratio IC50 405.0 None 10.1016/j.bmc.2009.06.056
None Unchecked Ratio IC50 405.0 None 10.1016/j.bmc.2009.12.060
None Unchecked Ratio IC50 405.0 None 10.1016/j.bmc.2010.06.094
None Unchecked Ratio IC50 405.0 None 10.1016/j.bmc.2013.12.002
None Unchecked Ratio IC50 405.0 None 10.1016/j.bmc.2020.115960
None Unchecked Ratio IC50 405.0 None 10.1016/j.bmcl.2008.01.021
None Unchecked Ratio IC50 405.0 None 10.1016/j.bmcl.2009.04.125
None Unchecked Ratio IC50 425.0 None 10.1016/j.bmc.2017.07.038
None Unchecked Ratio IC50 472.0 None 10.1016/j.ejmech.2009.04.009
None Unchecked Ratio IC50 473.0 None 10.1016/j.bmc.2007.07.021
None Unchecked Ratio IC50 473.0 None 10.1016/j.bmc.2007.11.003
None Unchecked Ratio IC50 473.0 None 10.1016/j.bmc.2007.12.006
None Unchecked Ratio IC50 473.0 None 10.1021/jm1001327
None Unchecked Ratio IC50 596.9 None 10.1016/j.bmcl.2017.02.076
None Unchecked Ratio IC50 600.0 None 10.1021/ml500156v
None Unchecked Ratio IC50 685.16 None 10.1016/j.bmc.2017.11.027
None Unchecked Ratio IC50 769.2 None 10.1016/j.bmcl.2015.05.059
None Unchecked Ratio IC50 1111.0 None 10.1021/acsmedchemlett.1c00065
None Unchecked Ratio IC50 1670.0 None 10.1016/j.bmc.2014.02.032
None Unchecked Ratio IC50 1783.0 None 10.1016/j.bmcl.2010.06.022
None Unchecked Ratio IC50 1783.0 None 10.1016/j.bmcl.2010.06.155
None Unchecked Ratio IC50 nan None 10.1016/j.bmcl.2014.08.050
None Unchecked Ratio IC50 nan None 10.1016/j.ejmech.2017.08.046
None Unchecked Ratio Ki 1.05 None 10.1016/j.bmc.2017.02.037
None Unchecked Ratio Ki 1.16 None 10.1016/j.bmc.2014.01.031
None Unchecked Ratio Ki 1.16 None 10.1016/j.bmcl.2011.07.090
None Unchecked Ratio Ki 1.3 None 10.1016/j.bmc.2013.07.044
None Unchecked Ratio Ki 1.3 None 10.1016/j.bmc.2014.01.031
None Unchecked Ratio Ki 1.31 None 10.1016/j.bmcl.2011.07.090
None Unchecked Ratio Ki 14.5 None 10.1016/j.bmc.2017.02.037
None Unchecked Ratio Ki 200.0 None 10.1016/j.bmc.2014.12.009
None Unchecked Ratio Ki 2778.0 None 10.1016/j.bmcl.2011.07.090
None Unchecked Ratio Ki 3125.0 None 10.1016/j.bmcl.2011.07.090
None Unchecked Selectivity 2.57 None 10.1021/jm020089e
None Unchecked Selectivity Index 26.0 None 10.1016/j.bmcl.2017.04.020
None Unchecked Selectivity Index 30.5 None 10.1016/j.ejmech.2014.04.065
None Unchecked Selectivity Index 166.7 None 10.1016/j.bmc.2011.04.027
None Unchecked Selectivity Index 166.93 None 10.1016/j.bmc.2015.07.070
None Unchecked Selectivity Index 405.0 None 10.1016/j.ejmech.2010.05.058
None Unchecked Selectivity Index 405.0 None 10.1016/j.ejmech.2020.112438
None Unchecked Selectivity ratio 0.03 None 10.1016/j.bmcl.2018.01.043
None Unchecked Selectivity ratio 0.032 None 10.1016/j.bmc.2011.06.019
None Unchecked Selectivity ratio 0.032 None 10.1016/j.bmc.2012.09.069
None Unchecked Selectivity ratio 3.75 None 10.1021/ml400500e
None Unchecked Selectivity ratio 375.0 None 10.1016/j.bmcl.2010.12.023
None Unchecked Selectivity ratio 375.0 None 10.1021/jm0407761

Metabolism Information