Asteromycin
AlkaPlorer ID: AK025470
Synonym: '', 'Ningnanmycin', 'Aspiculamycin', 'Gougerotin', 'Asteromycin'
IUPAC Name: (2S,3S,4S,5R,6R)-6-(4-amino-2-oxopyrimidin-1-yl)-4,5-dihydroxy-3-[[(2S)-3-hydroxy-2-[[2-(methylamino)acetyl]amino]propanoyl]amino]oxane-2-carboxamide
Structure
SMILES: CNCC(O)=N[C@@H](CO)C(O)=N[C@H]1[C@H](O)[C@@H](O)[C@H](N2C=CC(=N)N=C2O)O[C@@H]1C(=N)O
InChI: InChI=1S/C16H25N7O8/c1-19-4-8(25)20-6(5-24)14(29)22-9-10(26)11(27)15(31-12(9)13(18)28)23-3-2-7(17)21-16(23)30/h2-3,6,9-12,15,19,24,26-27H,4-5H2,1H3,(H2,18,28)(H,20,25)(H,22,29)(H2,17,21,30)/t6-,9-,10-,11+,12-,15+/m0/s1
InChIKey: AMNAZJFEONUVTD-KEWDHRJRSA-N
Source
| Species | Genus | Family | Order | Class | Phylum | Kingdom | Domain |
|---|---|---|---|---|---|---|---|
| Senna siamea | Senna | Fabaceae | Fabales | Magnoliopsida | Streptophyta | Viridiplantae | Eukaryota |
Properties Information
Molecule Weight: 443.41700000000014
TPSA？: 253.11
MolLogP？: -2.915459999999996
Number of H-Donors: 10
Number of H-Acceptors: 12
RingCount: 2
Activities Information
| Organism | Target Name | Standard Type | Standard Value | Standard Units | doi |
|---|---|---|---|---|---|
| Tobacco mosaic virus | Tobacco mosaic virus | AC50 | 68.0 | % | 10.1016/j.bmc.2008.09.070 |
| Tobacco mosaic virus | Tobacco mosaic virus | Activity | 18.9 | % | 10.1021/jf303550a |
| Tobacco mosaic virus | Tobacco mosaic virus | Activity | 23.0 | % | 10.1021/jf902543r |
| Tobacco mosaic virus | Tobacco mosaic virus | Activity | 25.2 | % | 10.1021/jf303550a |
| Tobacco mosaic virus | Tobacco mosaic virus | Activity | 37.7 | % | 10.1021/jf303550a |
| Tobacco mosaic virus | Tobacco mosaic virus | Activity | 39.0 | % | 10.1021/jf103440s |
| Tobacco mosaic virus | Tobacco mosaic virus | Activity | 40.9 | % | 10.1021/jf072394k |
| Tobacco mosaic virus | Tobacco mosaic virus | Activity | 41.9 | % | 10.1021/jf803215t |
| Tobacco mosaic virus | Tobacco mosaic virus | Activity | 42.1 | % | 10.1021/jf800405m |
| Tobacco mosaic virus | Tobacco mosaic virus | Activity | 44.0 | % | 10.1021/jf802489e |
| Tobacco mosaic virus | Tobacco mosaic virus | Activity | 47.5 | % | 10.1021/jf103440s |
| Tobacco mosaic virus | Tobacco mosaic virus | Activity | 47.9 | % | 10.1021/jf103440s |
| Tobacco mosaic virus | Tobacco mosaic virus | Activity | 48.0 | % | 10.1021/jf103440s |
| Tobacco mosaic virus | Tobacco mosaic virus | Activity | 48.7 | % | 10.1021/jf103440s |
| Tobacco mosaic virus | Tobacco mosaic virus | Activity | 50.0 | % | 10.1016/j.bmc.2007.12.035 |
| Tobacco mosaic virus | Tobacco mosaic virus | Activity | 50.5 | % | 10.1021/jf902543r |
| Tobacco mosaic virus | Tobacco mosaic virus | Activity | 50.7 | % | 10.1021/jf803215t |
| Tobacco mosaic virus | Tobacco mosaic virus | Activity | 51.0 | % | 10.1021/jf072394k |
| Tobacco mosaic virus | Tobacco mosaic virus | Activity | 51.3 | % | 10.1021/jf902543r |
| Tobacco mosaic virus | Tobacco mosaic virus | Activity | 54.2 | % | 10.1016/j.ejmech.2021.113815 |
| Tobacco mosaic virus | Tobacco mosaic virus | Activity | 54.8 | % | 10.1021/jf802489e |
| Tobacco mosaic virus | Tobacco mosaic virus | Activity | 55.0 | % | 10.1016/j.ejmech.2021.113815 |
| Tobacco mosaic virus | Tobacco mosaic virus | Activity | 55.4 | % | 10.1021/jf072394k |
| Tobacco mosaic virus | Tobacco mosaic virus | Activity | 55.8 | % | 10.1021/jf800405m |
| Tobacco mosaic virus | Tobacco mosaic virus | Activity | 55.9 | % | 10.1016/j.ejmech.2020.113102 |
| Tobacco mosaic virus | Tobacco mosaic virus | Activity | 56.0 | % | 10.1016/j.bmc.2008.09.070 |
| Tobacco mosaic virus | Tobacco mosaic virus | Activity | 56.0 | % | 10.1021/jf303550a |
| Tobacco mosaic virus | Tobacco mosaic virus | Activity | 56.2 | % | 10.1021/jf803215t |
| Tobacco mosaic virus | Tobacco mosaic virus | Activity | 57.0 | % | 10.1021/jf802489e |
| Tobacco mosaic virus | Tobacco mosaic virus | Activity | 57.1 | % | 10.1016/j.ejmech.2020.113102 |
| Tobacco mosaic virus | Tobacco mosaic virus | Activity | 57.3 | % | 10.1016/j.ejmech.2021.113815 |
| Tobacco mosaic virus | Tobacco mosaic virus | Activity | 57.8 | % | 10.1016/j.bmc.2007.12.035 |
| Tobacco mosaic virus | Tobacco mosaic virus | Activity | 58.8 | % | 10.1016/j.ejmech.2020.113102 |
| Tobacco mosaic virus | Tobacco mosaic virus | Activity | 59.9 | % | 10.1021/jf800405m |
| Tobacco mosaic virus | Tobacco mosaic virus | Activity | 59.9 | % | 10.1021/jf802489e |
| Tobacco mosaic virus | Tobacco mosaic virus | Activity | 60.1 | % | 10.1021/jf800405m |
| Tobacco mosaic virus | Tobacco mosaic virus | Activity | 60.2 | % | 10.1021/jf072394k |
| Tobacco mosaic virus | Tobacco mosaic virus | Activity | 60.6 | % | 10.1021/jf803215t |
| Tobacco mosaic virus | Tobacco mosaic virus | Activity | 66.6 | % | 10.1021/jf303550a |
| Tobacco mosaic virus | Tobacco mosaic virus | Activity | 68.4 | % | 10.1021/jf103440s |
| Tobacco mosaic virus | Tobacco mosaic virus | Activity | 68.5 | % | 10.1021/jf303550a |
| Tobacco mosaic virus | Tobacco mosaic virus | Activity | 69.0 | % | 10.1021/jf072394k |
| Tobacco mosaic virus | Tobacco mosaic virus | Activity | 70.0 | % | 10.1021/jf800405m |
| Tobacco mosaic virus | Tobacco mosaic virus | Activity | 72.0 | % | 10.1021/jf802489e |
| Tobacco mosaic virus | Tobacco mosaic virus | Activity | 78.4 | % | 10.1021/jf072394k |
| Tobacco mosaic virus | Tobacco mosaic virus | Activity | 80.0 | % | 10.1021/jf800405m |
| Tobacco mosaic virus | Tobacco mosaic virus | Activity | 81.1 | % | 10.1021/jf802489e |
| Tobacco mosaic virus | Tobacco mosaic virus | Activity | 97.0 | % | 10.1016/j.bmc.2008.09.070 |
| Tobacco mosaic virus | Tobacco mosaic virus | Activity | 98.0 | % | 10.1021/jf802489e |
| Tobacco mosaic virus | Tobacco mosaic virus | Activity | 99.5 | % | 10.1021/jf800405m |
| Tobacco mosaic virus | Tobacco mosaic virus | Activity | 100.0 | % | 10.1016/j.bmc.2007.12.035 |
| Tobacco mosaic virus | Tobacco mosaic virus | Activity | 100.0 | % | 10.1021/jf072394k |
| Tobacco mosaic virus | Tobacco mosaic virus | EC50 | 50.9 | ug.mL-1 | 10.1021/jf800405m |
| Tobacco mosaic virus | Tobacco mosaic virus | EC50 | 52.7 | ug.mL-1 | 10.1021/jf802489e |
| Tobacco mosaic virus | Tobacco mosaic virus | EC50 | 55.6 | ug.mL-1 | 10.1021/jf072394k |
| Tobacco mosaic virus | Tobacco mosaic virus | EC50 | 227.0 | ug.mL-1 | 10.1021/jf803215t |
| Tobacco mosaic virus | Tobacco mosaic virus | EC50 | 245.9 | ug.mL-1 | 10.1021/jf072394k |
| Tobacco mosaic virus | Tobacco mosaic virus | EC50 | 440.0 | ug.mL-1 | 10.1021/jf902543r |
| Tobacco mosaic virus | Tobacco mosaic virus | EC50 | 129000.0 | nM | 10.1021/jf901632j |
| Tobacco mosaic virus | Tobacco mosaic virus | EC50 | 135000.0 | nM | 10.1021/jf901632j |
| Tobacco mosaic virus | Tobacco mosaic virus | IC50 | 44.6 | ug.mL-1 | 10.1021/np501057f |
| Tobacco mosaic virus | Tobacco mosaic virus | IC50 | 52.1 | ug.mL-1 | 10.1021/jf205362d |
| Tobacco mosaic virus | Tobacco mosaic virus | IC50 | 42200.0 | nM | 10.1021/np300727f |
| Tobacco mosaic virus | Tobacco mosaic virus | IC50 | 49900.0 | nM | 10.1021/np300395m |
| Tobacco mosaic virus | Tobacco mosaic virus | IC50 | 117300.0 | nM | 10.1021/jf903434h |
| Tobacco mosaic virus | Tobacco mosaic virus | Inhibition | 11.8 | % | 10.1021/np300395m |
| Tobacco mosaic virus | Tobacco mosaic virus | Inhibition | 17.9 | % | 10.1021/np501057f |
| Tobacco mosaic virus | Tobacco mosaic virus | Inhibition | 18.9 | % | 10.1021/jf3013376 |
| Tobacco mosaic virus | Tobacco mosaic virus | Inhibition | 20.8 | % | 10.1021/np501057f |
| Tobacco mosaic virus | Tobacco mosaic virus | Inhibition | 22.6 | % | 10.1021/np300395m |
| Tobacco mosaic virus | Tobacco mosaic virus | Inhibition | 23.1 | % | 10.1021/jf304905k |
| Tobacco mosaic virus | Tobacco mosaic virus | Inhibition | 23.9 | % | 10.1021/jf3013376 |
| Tobacco mosaic virus | Tobacco mosaic virus | Inhibition | 25.0 | % | 10.1021/jf205362d |
| Tobacco mosaic virus | Tobacco mosaic virus | Inhibition | 25.0 | % | 10.1021/jf304905k |
| Tobacco mosaic virus | Tobacco mosaic virus | Inhibition | 25.2 | % | 10.1021/jf3013376 |
| Tobacco mosaic virus | Tobacco mosaic virus | Inhibition | 25.3 | % | 10.1021/jf903434h |
| Tobacco mosaic virus | Tobacco mosaic virus | Inhibition | 26.8 | % | 10.1021/jf304905k |
| Tobacco mosaic virus | Tobacco mosaic virus | Inhibition | 27.0 | % | 10.1021/jf902543r |
| Tobacco mosaic virus | Tobacco mosaic virus | Inhibition | 27.4 | % | 10.1021/np300395m |
| Tobacco mosaic virus | Tobacco mosaic virus | Inhibition | 27.8 | % | 10.1016/j.ejmech.2019.02.002 |
| Tobacco mosaic virus | Tobacco mosaic virus | Inhibition | 28.0 | % | 10.1021/jf903434h |
| Tobacco mosaic virus | Tobacco mosaic virus | Inhibition | 28.2 | % | 10.1021/jf902543r |
| Tobacco mosaic virus | Tobacco mosaic virus | Inhibition | 28.9 | % | 10.1021/jf051050w |
| Tobacco mosaic virus | Tobacco mosaic virus | Inhibition | 30.0 | % | 10.1021/np300727f |
| Tobacco mosaic virus | Tobacco mosaic virus | Inhibition | 30.2 | % | 10.1021/np300395m |
| Tobacco mosaic virus | Tobacco mosaic virus | Inhibition | 30.3 | % | 10.1021/jf205362d |
| Tobacco mosaic virus | Tobacco mosaic virus | Inhibition | 30.4 | % | 10.1021/jf303550a |
| Tobacco mosaic virus | Tobacco mosaic virus | Inhibition | 31.8 | % | 10.1021/np300727f |
| Tobacco mosaic virus | Tobacco mosaic virus | Inhibition | 32.1 | % | 10.1021/jf205362d |
| Tobacco mosaic virus | Tobacco mosaic virus | Inhibition | 33.9 | % | 10.1021/np501057f |
| Tobacco mosaic virus | Tobacco mosaic virus | Inhibition | 37.7 | % | 10.1021/jf3013376 |
| Tobacco mosaic virus | Tobacco mosaic virus | Inhibition | 37.9 | % | 10.1021/jf903434h |
| Tobacco mosaic virus | Tobacco mosaic virus | Inhibition | 38.3 | % | 10.1021/jf205362d |
| Tobacco mosaic virus | Tobacco mosaic virus | Inhibition | 38.4 | % | 10.1021/jf304905k |
| Tobacco mosaic virus | Tobacco mosaic virus | Inhibition | 38.6 | % | 10.1021/np501057f |
| Tobacco mosaic virus | Tobacco mosaic virus | Inhibition | 40.7 | % | 10.1021/np501057f |
| Tobacco mosaic virus | Tobacco mosaic virus | Inhibition | 42.1 | % | 10.1021/jf205362d |
| Tobacco mosaic virus | Tobacco mosaic virus | Inhibition | 42.1 | % | 10.1021/jf902543r |
| Tobacco mosaic virus | Tobacco mosaic virus | Inhibition | 42.6 | % | 10.1021/jf205362d |
| Tobacco mosaic virus | Tobacco mosaic virus | Inhibition | 46.6 | % | 10.1021/jf903434h |
| Tobacco mosaic virus | Tobacco mosaic virus | Inhibition | 48.3 | % | 10.1021/np300395m |
| Tobacco mosaic virus | Tobacco mosaic virus | Inhibition | 50.2 | % | 10.1021/np501057f |
| Tobacco mosaic virus | Tobacco mosaic virus | Inhibition | 51.0 | % | 10.1021/jf901632j |
| Tobacco mosaic virus | Tobacco mosaic virus | Inhibition | 52.6 | % | 10.1021/jf901632j |
| Tobacco mosaic virus | Tobacco mosaic virus | Inhibition | 53.8 | % | 10.1021/jf901632j |
| Tobacco mosaic virus | Tobacco mosaic virus | Inhibition | 54.2 | % | 10.1021/jf304905k |
| Tobacco mosaic virus | Tobacco mosaic virus | Inhibition | 54.5 | % | 10.1021/jf901632j |
| Tobacco mosaic virus | Tobacco mosaic virus | Inhibition | 55.6 | % | 10.1021/jf901632j |
| Tobacco mosaic virus | Tobacco mosaic virus | Inhibition | 56.0 | % | 10.1021/jf3013376 |
| Tobacco mosaic virus | Tobacco mosaic virus | Inhibition | 56.4 | % | 10.1016/j.ejmech.2019.02.002 |
| Tobacco mosaic virus | Tobacco mosaic virus | Inhibition | 56.5 | % | 10.1021/jf205362d |
| Tobacco mosaic virus | Tobacco mosaic virus | Inhibition | 57.3 | % | 10.1021/np501057f |
| Tobacco mosaic virus | Tobacco mosaic virus | Inhibition | 57.7 | % | 10.1021/jf902861m |
| Tobacco mosaic virus | Tobacco mosaic virus | Inhibition | 57.9 | % | 10.1021/jf304905k |
| Tobacco mosaic virus | Tobacco mosaic virus | Inhibition | 58.7 | % | 10.1021/jf304905k |
| Tobacco mosaic virus | Tobacco mosaic virus | Inhibition | 58.9 | % | 10.1021/jf902861m |
| Tobacco mosaic virus | Tobacco mosaic virus | Inhibition | 58.9 | % | 10.1021/np501057f |
| Tobacco mosaic virus | Tobacco mosaic virus | Inhibition | 59.3 | % | 10.1021/jf902543r |
| Tobacco mosaic virus | Tobacco mosaic virus | Inhibition | 60.0 | % | 10.1021/jf901632j |
| Tobacco mosaic virus | Tobacco mosaic virus | Inhibition | 61.3 | % | 10.1021/np300395m |
| Tobacco mosaic virus | Tobacco mosaic virus | Inhibition | 66.6 | % | 10.1021/jf3013376 |
| Tobacco mosaic virus | Tobacco mosaic virus | Inhibition | 67.5 | % | 10.1021/jf903434h |
| Tobacco mosaic virus | Tobacco mosaic virus | Inhibition | 68.5 | % | 10.1021/jf3013376 |
| Tobacco mosaic virus | Tobacco mosaic virus | Inhibition | 69.2 | % | 10.1021/np501057f |
| Tobacco mosaic virus | Tobacco mosaic virus | Inhibition | 69.3 | % | 10.1021/jf304905k |
| Tobacco mosaic virus | Tobacco mosaic virus | Inhibition | 70.2 | % | 10.1021/jf3013376 |
| Tobacco mosaic virus | Tobacco mosaic virus | Inhibition | 71.4 | % | 10.1021/jf303550a |
| Tobacco mosaic virus | Tobacco mosaic virus | Inhibition | 82.7 | % | 10.1021/np300395m |
| Tobacco mosaic virus | Tobacco mosaic virus | Inhibition | 88.9 | % | 10.1021/jf051050w |
| Tobacco mosaic virus | Tobacco mosaic virus | Inhibition | 96.0 | % | 10.1021/jf902861m |
| None | Unchecked | Ratio | 13.85 | None | 10.1016/j.bmc.2008.09.070 |
| None | Unchecked | Ratio | 17.95 | None | 10.1016/j.bmc.2008.09.070 |