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5,11-dimethyl-6H-pyrido[4,3-b]carbazol-9-ol

AlkaPlorer ID: AK025507

Synonym: None

IUPAC Name: 5,11-dimethyl-6H-pyrido[4,3-b]carbazol-9-ol

Structure

SMILES: CC1=C2NC3=CC=C(O)C=C3C2=C(C)C2=CN=CC=C12

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InChI: InChI=1S/C17H14N2O/c1-9-14-8-18-6-5-12(14)10(2)17-16(9)13-7-11(20)3-4-15(13)19-17/h3-8,19-20H,1-2H3

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InChIKey: QZTWUDDGLIDXSE-UHFFFAOYSA-N

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Source

Species Genus Family Order Class Phylum Kingdom Domain
Ochrosia elliptica Ochrosia Apocynaceae Gentianales Magnoliopsida Streptophyta Viridiplantae Eukaryota

Properties Information

Molecule Weight: 262.312

TPSA？: 48.91

MolLogP？: 4.191740000000002

Number of H-Donors: 2

Number of H-Acceptors: 2

RingCount: 4

Activities Information

Organism Target Name Standard Type Standard Value Standard Units doi
Escherichia coli Escherichia coli MIC 8.0 ug.mL-1 10.1016/j.bmc.2011.07.020
Escherichia coli Escherichia coli MIC 16.0 ug.mL-1 10.1016/j.bmc.2011.07.020
Homo sapiens Fibroblast growth factor receptor 3 IC50 400.0 nM 10.1021/jm050231m
Homo sapiens Homo sapiens TGI 2800.0 nM 10.1021/jm00040a010
Homo sapiens Homo sapiens TGI 3400.0 nM 10.1021/jm00040a010
Homo sapiens Homo sapiens TGI correlation coefficient 0.5 None 10.1021/jm00040a010
Homo sapiens NCI-H358 IC50 5600.0 nM 10.1021/jm00104a011
Homo sapiens NCI-H417 IC50 3500.0 nM 10.1021/jm00104a011
Homo sapiens NCI-H460 IC50 2600.0 nM 10.1021/jm00104a011
Homo sapiens NCI-H69 IC50 1700.0 nM 10.1021/jm00104a011
Homo sapiens Platelet-derived growth factor receptor alpha IC50 600.0 nM 10.1021/jm050231m
Homo sapiens Stem cell growth factor receptor IC50 10.0 nM 10.1021/jm050231m
Homo sapiens Stem cell growth factor receptor IC50 400.0 nM 10.1021/jm050231m
Mus musculus L1210 Co 0.04 uM 10.1021/jm00383a011
Mus musculus L1210 ED50 0.08 uM 10.1021/jm00383a011
Mus musculus L1210 ID50 0.015 uM 10.1021/jm00135a010
Mus musculus L1210 ID50 0.015 uM 10.1021/jm00364a015
Mus musculus L1210 LD0 50.0 mg kg-1 10.1021/jm00135a010
Mus musculus Mus musculus IC50 900.0 nM 10.1016/j.bmc.2016.12.031
Mus musculus Mus musculus ILS 53.0 % 10.1021/jm00135a010
Mus musculus Mus musculus ILS 79.0 % 10.1021/jm00402a007
Mus musculus Mus musculus ILS 91.0 % 10.1021/jm00402a007
Mus musculus Mus musculus ILS nan None 10.1021/jm00402a007
Mus musculus Mus musculus NADH oxidation 0.0 nM min-1 10.1021/jm00135a010
Mus musculus Mus musculus NADH oxidation 0.5 nM min-1 10.1021/jm00135a010
Mus musculus Mus musculus NADH oxidation 5.5 nM min-1 10.1021/jm00135a010
Mus musculus Mus musculus NADH oxidation 6.5 nM min-1 10.1021/jm00135a010
Mus musculus Mus musculus NADH oxidation 7.2 nM min-1 10.1021/jm00135a010
Mus musculus Mus musculus NADH oxidation 7.8 nM min-1 10.1021/jm00135a010
Mus musculus Mus musculus NADH oxidation 10.2 nM min-1 10.1021/jm00135a010
Mus musculus Mus musculus NADH oxidized 1.2 nM min-1 10.1021/jm00135a010
Mus musculus Mus musculus NADH oxidized 10.5 nM min-1 10.1021/jm00135a010
Mus musculus Mus musculus Oxygen consumed 0.0 nM min-1 10.1021/jm00135a010
Mus musculus Mus musculus Oxygen uptake 0.0 nM min-1 10.1021/jm00135a010
Mus musculus Mus musculus Oxygen uptake 0.28 nM min-1 10.1021/jm00135a010
Mus musculus Mus musculus Oxygen uptake 0.52 nM min-1 10.1021/jm00135a010
Plasmodium falciparum Plasmodium falciparum IC50 300.0 nM 10.1016/j.bmcl.2014.04.070
Staphylococcus aureus Staphylococcus aureus Activity 71.9 % 10.1016/j.bmc.2011.07.020
Staphylococcus aureus Staphylococcus aureus MIC 8.0 ug.mL-1 10.1016/j.bmc.2011.07.020
None NON-PROTEIN TARGET IC50 440.0 nM 10.1016/j.bmc.2016.12.031
None NON-PROTEIN TARGET IC50 nan None 10.1016/j.bmc.2016.12.031
None Nucleic Acid Log Kd 0.3 None 10.1021/jm00370a007
None Unchecked Activity nan None 10.1016/j.bmc.2016.12.031
None Unchecked IC50 192000.0 nM 10.1016/j.bmc.2011.07.020
None Unchecked Ka 107.0 10'5/M 10.1016/j.bmc.2016.12.031
None Unchecked Ka nan None 10.1016/j.bmc.2016.12.031
None Unchecked Ratio 0.8 None 10.1021/jm00040a010

Metabolism Information