Molecule

Vegfrecine

AlkaPlorer ID: AK025636

Synonym: None

IUPAC Name: 2-hydroxy-3-(2-hydroxyanilino)-6-imino-5-oxocyclohexa-1,3-diene-1-carboxamide

SMILES: N=C(O)C1=C(N)C(=O)C=C(NC2=CC=CC=C2O)C1=O

InChI: InChI=1S/C13H11N3O4/c14-11-9(18)5-7(12(19)10(11)13(15)20)16-6-3-1-2-4-8(6)17/h1-5,16-17H,14H2,(H2,15,20)

InChIKey: PAYLFJFRBIHGBV-UHFFFAOYSA-N

LOTUS: LTS0219245

NPASS: NPC47986

COCONUT: CNP0151230

Species	Genus	Family	Order	Class	Phylum	Kingdom	Domain
Streptomyces sp. MK931-CF8	Streptomyces	Streptomycetaceae	Kitasatosporales	Actinomycetes	Actinomycetota	None	Bacteria

Molecule Weight: 273.24800000000005

TPSA？: 136.5

MolLogP？: 0.5878699999999997

Number of H-Donors: 5

Number of H-Acceptors: 6

RingCount: 2

Organism	Target Name	Standard Type	Standard Value	Standard Units	doi
Homo sapiens	Epidermal growth factor receptor erbB1	IC50	2600.0	nM	10.1021/np300535c
Homo sapiens	Fibroblast growth factor receptor	IC50	730.0	nM	10.1021/np300535c
Homo sapiens	Platelet-derived growth factor receptor alpha	IC50	3200.0	nM	10.1021/np300535c
Homo sapiens	Platelet-derived growth factor receptor beta	IC50	480.0	nM	10.1021/np300535c
Homo sapiens	Vascular endothelial growth factor receptor 1	Activity	nan	None	10.1021/np300535c
Homo sapiens	Vascular endothelial growth factor receptor 1	IC50	18.0	nM	10.1021/np300535c
Homo sapiens	Vascular endothelial growth factor receptor 1	Ratio	100.0	None	10.1021/np300535c
Homo sapiens	Vascular endothelial growth factor receptor 2	IC50	11.0	nM	10.1021/np300535c
Homo sapiens	Vascular endothelial growth factor receptor 3	IC50	1.8	nM	10.1021/np300535c
Mus musculus	NIH3T3	Activity	3.0	uM	10.1021/np300535c
Mus musculus	NIH3T3	Activity	12.0	uM	10.1021/np300535c
Mus musculus	NIH3T3	Activity	nan	None	10.1021/np300535c