Platencin A2
AlkaPlorer ID: AK025785
Synonym: None
IUPAC Name: 2,4-dihydroxy-3-[3-[(5S,9S)-9-hydroxy-5-methyl-12-methylidene-4-oxo-5-tricyclo[6.2.2.01,6]dodec-2-enyl]propanoylamino]benzoic acid
Structure
SMILES: C=C1CC23C=CC(=O)[C@@](C)(CCC(O)=NC4=C(O)C=CC(C(=O)O)=C4O)C2CC1[C@@H](O)C3
InChI: InChI=1S/C24H27NO7/c1-12-10-24-8-5-18(28)23(2,17(24)9-14(12)16(27)11-24)7-6-19(29)25-20-15(26)4-3-13(21(20)30)22(31)32/h3-5,8,14,16-17,26-27,30H,1,6-7,9-11H2,2H3,(H,25,29)(H,31,32)/t14?,16-,17?,23-,24?/m0/s1
InChIKey: VABLHCSPDCPVNA-CLEJQCKHSA-N
Reference
Isolation, structure and biological activities of platencin A2–A4 from Streptomyces platensis
PubChem CID: 54583039
LOTUS: LTS0037771
{NPAtlas: NPA003956
Source
| Species | Genus | Family | Order | Class | Phylum | Kingdom | Domain |
|---|---|---|---|---|---|---|---|
| Streptomyces platensis | Streptomyces | Streptomycetaceae | Kitasatosporales | Actinomycetes | Actinomycetota | None | Bacteria |
Properties Information
Molecule Weight: 441.4800000000001
TPSA？: 147.65
MolLogP？: 3.642800000000001
Number of H-Donors: 5
Number of H-Acceptors: 6
RingCount: 5
Activities Information
| Organism | Target Name | Standard Type | Standard Value | Standard Units | doi |
|---|---|---|---|---|---|
| Enterococcus faecalis | Enterococcus faecalis | Activity | None | None | 10.1021/np100635f |
| Enterococcus faecium | Enterococcus faecium | Activity | None | None | 10.1021/np100635f |
| Escherichia coli | Escherichia coli | Activity | None | None | 10.1021/np100635f |
| Haemophilus influenzae | Haemophilus influenzae | Activity | None | None | 10.1021/np100635f |
| Staphylococcus aureus | 3-oxoacyl-[acyl-carrier-protein] synthase 2 | Inhibition | None | % | 10.1021/np100635f |
| Staphylococcus aureus | Staphylococcus aureus | Activity | None | None | 10.1021/np100635f |
| Streptococcus pneumoniae | Streptococcus pneumoniae | Activity | None | None | 10.1021/np100635f |