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UNPD186686

AlkaPlorer ID: AK026165

Synonym: None

IUPAC Name: 2-[(E)-[1-(2-amino-1,3-thiazol-4-yl)-2-[[(2S,3S)-2-methyl-4-oxo-1-sulfoazetidin-3-yl]amino]-2-oxoethylidene]amino]oxy-2-methylpropanoic acid

Structure

SMILES: C[C@H]1[C@H](N=C(O)/C(=N\OC(C)(C)C(=O)O)C2=CSC(=N)N2)C(=O)N1S(=O)(=O)O

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InChI: InChI=1S/C13H17N5O8S2/c1-5-7(10(20)18(5)28(23,24)25)16-9(19)8(6-4-27-12(14)15-6)17-26-13(2,3)11(21)22/h4-5,7H,1-3H3,(H2,14,15)(H,16,19)(H,21,22)(H,23,24,25)/b17-8-/t5-,7-/m0/s1

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InChIKey: WZPBZJONDBGPKJ-VEHQQRBSSA-N

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Reference

PubChem CID: 135398736

CAS: 78110-38-0

NPASS: NPC487964

Source

Species Genus Family Order Class Phylum Kingdom Domain

Properties Information

Molecule Weight: 435.44000000000005

TPSA？: 205.8

MolLogP？: -0.5018299999999982

Number of H-Donors: 5

Number of H-Acceptors: 9

RingCount: 2

Activities Information

Organism Target Name Standard Type Standard Value Standard Units doi
Acinetobacter Acinetobacter MIC 16.0 ug.mL-1 10.1128/aac.01634-07
Acinetobacter baumannii Acinetobacter baumannii Activity nan None 10.1128/aac.00963-09
Acinetobacter baumannii Acinetobacter baumannii MIC 1.0 ug.mL-1 10.1128/aac.00072-09
Acinetobacter baumannii Acinetobacter baumannii MIC 2.0 ug.mL-1 10.1016/j.ejmech.2010.10.007
Acinetobacter baumannii Acinetobacter baumannii MIC 4.0 ug.mL-1 10.1021/jm400560z
Acinetobacter baumannii Acinetobacter baumannii MIC 6.0 ug.mL-1 10.1128/aac.01037-09
Acinetobacter baumannii Acinetobacter baumannii MIC 8.0 ug.mL-1 10.1128/aac.00050-10
Acinetobacter baumannii Acinetobacter baumannii MIC 8.0 ug.mL-1 10.1128/aac.00267-07
Acinetobacter baumannii Acinetobacter baumannii MIC 12.0 ug.mL-1 10.1128/aac.00050-10
Acinetobacter baumannii Acinetobacter baumannii MIC 12.0 ug.mL-1 10.1128/aac.01037-09
Acinetobacter baumannii Acinetobacter baumannii MIC 12.0 ug.mL-1 10.1128/aac.01512-06
Acinetobacter baumannii Acinetobacter baumannii MIC 12.0 ug.mL-1 10.1128/aac.01684-07
Acinetobacter baumannii Acinetobacter baumannii MIC 16.0 ug.mL-1 10.1128/aac.00267-07
Acinetobacter baumannii Acinetobacter baumannii MIC 16.0 ug.mL-1 10.1128/aac.00393-08
Acinetobacter baumannii Acinetobacter baumannii MIC 16.0 ug.mL-1 10.1128/aac.00838-06
Acinetobacter baumannii Acinetobacter baumannii MIC 16.0 ug.mL-1 10.1128/aac.01037-09
Acinetobacter baumannii Acinetobacter baumannii MIC 16.0 ug.mL-1 10.1128/aac.01512-06
Acinetobacter baumannii Acinetobacter baumannii MIC 16.0 ug.mL-1 10.1128/aac.01525-09
Acinetobacter baumannii Acinetobacter baumannii MIC 16.0 ug.mL-1 10.1128/aac.01634-07
Acinetobacter baumannii Acinetobacter baumannii MIC 16.0 ug.mL-1 10.1128/aac.01684-07
Acinetobacter baumannii Acinetobacter baumannii MIC 24.0 ug.mL-1 10.1128/aac.01512-06
Acinetobacter baumannii Acinetobacter baumannii MIC 24.0 ug.mL-1 10.1128/aac.01684-07
Acinetobacter baumannii Acinetobacter baumannii MIC 32.0 ug.mL-1 10.1021/jm500219c
Acinetobacter baumannii Acinetobacter baumannii MIC 32.0 ug.mL-1 10.1021/ml200012f
Acinetobacter baumannii Acinetobacter baumannii MIC 32.0 ug.mL-1 10.1128/aac.00861-09
Acinetobacter baumannii Acinetobacter baumannii MIC 32.0 ug.mL-1 10.1128/aac.00978-07
Acinetobacter baumannii Acinetobacter baumannii MIC 32.0 ug.mL-1 10.1128/aac.01037-09
Acinetobacter baumannii Acinetobacter baumannii MIC 32.0 ug.mL-1 10.1128/aac.01512-06
Acinetobacter baumannii Acinetobacter baumannii MIC 32.0 ug.mL-1 10.1128/aac.01525-09
Acinetobacter baumannii Acinetobacter baumannii MIC 32.0 ug.mL-1 10.1128/aac.01684-07
Acinetobacter baumannii Acinetobacter baumannii MIC 48.0 ug.mL-1 10.1128/aac.01037-09
Acinetobacter baumannii Acinetobacter baumannii MIC 48.0 ug.mL-1 10.1128/aac.01512-06
Acinetobacter baumannii Acinetobacter baumannii MIC 48.0 ug.mL-1 10.1128/aac.01684-07
Acinetobacter baumannii Acinetobacter baumannii MIC 64.0 ug.mL-1 10.1016/j.bmcl.2021.127878
Acinetobacter baumannii Acinetobacter baumannii MIC 64.0 ug.mL-1 10.1021/acs.jmedchem.6b01261
Acinetobacter baumannii Acinetobacter baumannii MIC 64.0 ug.mL-1 10.1128/aac.00393-08
Acinetobacter baumannii Acinetobacter baumannii MIC 64.0 ug.mL-1 10.1128/aac.00978-07
Acinetobacter baumannii Acinetobacter baumannii MIC 64.0 ug.mL-1 10.1128/aac.01414-07
Acinetobacter baumannii Acinetobacter baumannii MIC 64.0 ug.mL-1 10.1128/aac.01433-06
Acinetobacter baumannii Acinetobacter baumannii MIC 64.0 ug.mL-1 10.1128/aac.01512-06
Acinetobacter baumannii Acinetobacter baumannii MIC 64.0 ug.mL-1 10.1128/aac.01684-07
Acinetobacter baumannii Acinetobacter baumannii MIC 96.0 ug.mL-1 10.1128/aac.01684-07
Acinetobacter baumannii Acinetobacter baumannii MIC 128.0 ug.mL-1 10.1128/aac.00393-08
Acinetobacter baumannii Acinetobacter baumannii MIC 128.0 ug.mL-1 10.1128/aac.00978-07
Acinetobacter baumannii Acinetobacter baumannii MIC 128.0 ug.mL-1 10.1128/aac.01139-06
Acinetobacter baumannii Acinetobacter baumannii MIC 256.0 ug.mL-1 10.1128/aac.00050-10
Acinetobacter baumannii Acinetobacter baumannii MIC 256.0 ug.mL-1 10.1128/aac.00072-09
Acinetobacter baumannii Acinetobacter baumannii MIC 256.0 ug.mL-1 10.1128/aac.01037-09
Acinetobacter baumannii Acinetobacter baumannii MIC 256.0 ug.mL-1 10.1128/aac.01684-07
Acinetobacter baumannii Acinetobacter baumannii MIC 12500.0 nM 10.1021/acs.jmedchem.7b01164
Acinetobacter baumannii Acinetobacter baumannii MIC 25000.0 nM 10.1021/acs.jmedchem.7b01164
Acinetobacter baumannii Acinetobacter baumannii MIC 50000.0 nM 10.1021/acs.jmedchem.7b01164
Acinetobacter baumannii Acinetobacter baumannii MIC nan None 10.1128/aac.00393-08
Acinetobacter baumannii Acinetobacter baumannii MIC50 32.0 ug.mL-1 10.1016/j.ejmech.2021.113436
Acinetobacter baumannii Acinetobacter baumannii MIC90 32.0 ug.mL-1 10.1016/j.ejmech.2021.113436
Acinetobacter baumannii Acinetobacter baumannii MIC90 32.0 ug.mL-1 10.1021/jm2014748
Acinetobacter baumannii Acinetobacter baumannii MIC90 512.0 ug.mL-1 10.1021/jm501506f
Acinetobacter baumannii ADC-11 Kcat/Km 2.0 /uM/s 10.1128/aac.00050-10
Acinetobacter baumannii ADC-11 Ki 3000.0 nM 10.1128/aac.00050-10
Acinetobacter baumannii Beta-lactamase ADC-33 Kcat 0.015 /s 10.1128/aac.00050-10
Acinetobacter baumannii Beta-lactamase ADC-33 Kcat nan None 10.1128/aac.00050-10
Acinetobacter baumannii Beta-lactamase ADC-33 Ki 7.0 nM 10.1128/aac.00050-10
Acinetobacter calcoaceticus Acinetobacter calcoaceticus MIC 8.0 ug.mL-1 10.1016/j.ejmech.2018.03.031
Acinetobacter calcoaceticus Acinetobacter calcoaceticus MIC 128.0 ug.mL-1 10.1016/j.ejmech.2018.03.031
Acinetobacter genomosp. 3 ADC-14 protein Kcat nan None 10.1128/aac.00485-08
Acinetobacter genomosp. 3 ADC-14 protein Km 6010.0 nM 10.1128/aac.00485-08
Acinetobacter genomosp. 3 ADC-16 protein Kcat nan None 10.1128/aac.00485-08
Acinetobacter genomosp. 3 ADC-16 protein Km 3850.0 nM 10.1128/aac.00485-08
Acinetobacter genomosp. 3 ADC-18 protein Kcat nan None 10.1128/aac.00485-08
Acinetobacter genomosp. 3 ADC-18 protein Km 4540.0 nM 10.1128/aac.00485-08
Acinetobacter haemolyticus Acinetobacter haemolyticus MIC 4.0 ug.mL-1 10.1128/aac.00267-07
Acinetobacter pittii Acinetobacter pittii Activity 94.7 % 10.1128/aac.01624-09
Acinetobacter pittii Acinetobacter pittii MIC 16.0 ug.mL-1 10.1128/aac.01624-09
Acinetobacter pittii Acinetobacter pittii MIC50 32.0 ug.mL-1 10.1128/aac.01624-09
Acinetobacter pittii Acinetobacter pittii MIC90 32.0 ug.mL-1 10.1128/aac.01624-09
Acinetobacter radioresistens Acinetobacter radioresistens MIC 8.0 ug.mL-1 10.1128/aac.00999-08
Acinetobacter sp. Acinetobacter sp. MIC 8.0 ug.mL-1 10.1128/aac.01525-09
Acinetobacter sp. Acinetobacter sp. MIC 16.0 ug.mL-1 10.1128/aac.00838-06
Acinetobacter sp. Acinetobacter sp. MIC50 32.0 ug.mL-1 10.1021/jm400560z
Acinetobacter sp. Acinetobacter sp. MIC50 32.0 ug.mL-1 10.1021/ml200012f
Acinetobacter sp. Acinetobacter sp. MIC50 32.0 ug.mL-1 10.1128/aac.01525-09
Acinetobacter sp. Acinetobacter sp. MIC90 32.0 ug.mL-1 10.1021/jm2014875
Acinetobacter sp. Acinetobacter sp. MIC90 32.0 ug.mL-1 10.1128/aac.01525-09
Acinetobacter sp. Acinetobacter sp. MIC90 64.0 ug.mL-1 10.1021/jm400560z
Acinetobacter sp. Acinetobacter sp. MIC90 64.0 ug.mL-1 10.1021/ml200012f
Aeromonas allosaccharophila Extended-spectrum beta-lactamase PER-6 Kcat 3.0 /s 10.1128/aac.01585-09
Aeromonas allosaccharophila Extended-spectrum beta-lactamase PER-6 Kcat/Km 75.0 /uM/s 10.1128/aac.01585-09
Aeromonas allosaccharophila Extended-spectrum beta-lactamase PER-6 Km 40000.0 nM 10.1128/aac.01585-09
Aeromonas caviae Aeromonas caviae IZ 24.0 mm 10.1128/aac.01462-06
Aeromonas caviae Aeromonas caviae MIC 512.0 ug.mL-1 10.1128/aac.01462-06
Aeromonas caviae IMP-19 Kcat 0.1 /s 10.1128/aac.01462-06
Aeromonas caviae IMP-19 Kcat/Km nan None 10.1128/aac.01462-06
Aeromonas caviae IMP-19 Km nan None 10.1128/aac.01462-06
Bacillus clausii Beta-lactamase Activity nan None 10.1128/aac.00537-07
Bacillus clausii Beta-lactamase Kcat 0.3 /s 10.1128/aac.00537-07
Bacillus clausii Beta-lactamase Kcat/Km nan None 10.1128/aac.00537-07
Bacillus clausii Beta-lactamase Km nan None 10.1128/aac.00537-07
Bacillus subtilis Bacillus subtilis MIC 64.0 ug.mL-1 10.1128/aac.01790-09
Bacteroides fragilis Bacteroides fragilis MIC 128.0 ug.mL-1 10.1016/S0960-894X(01)80932-X
Bacteroides thetaiotaomicron Bacteroides thetaiotaomicron MIC 256.0 ug.mL-1 10.1016/S0960-894X(01)80932-X
Bos taurus Progesterone receptor IC50 nan None None
Bos taurus Progesterone receptor Ki nan None None
Burkholderia cenocepacia Burkholderia cenocepacia MIC 4.0 ug.mL-1 10.1128/aac.00946-08
Burkholderia cenocepacia Burkholderia cenocepacia MIC 16.0 ug.mL-1 10.1128/aac.00946-08
Burkholderia cenocepacia Burkholderia cenocepacia MIC 512.0 ug.mL-1 10.1128/aac.00946-08
Burkholderia cenocepacia PenB class A beta-lactamase Kcat 30.0 /s 10.1128/aac.00946-08
Burkholderia cenocepacia PenB class A beta-lactamase Kcat/Km 10.0 /uM/s 10.1128/aac.00946-08
Burkholderia cenocepacia PenB class A beta-lactamase Km 2500000.0 nM 10.1128/aac.00946-08
Burkholderia cepacia Burkholderia cepacia Activity 2.0 % 10.1128/aac.00954-06
Burkholderia cepacia Burkholderia cepacia MIC50 32.0 ug.mL-1 10.1128/aac.00248-09
Burkholderia cepacia Burkholderia cepacia MIC90 128.0 ug.mL-1 10.1128/aac.00248-09
Campylobacter coli Campylobacter coli MIC 8.0 ug.mL-1 10.1128/aac.01655-08
Campylobacter coli Campylobacter coli MIC 32.0 ug.mL-1 10.1128/aac.01655-08
Campylobacter coli Campylobacter coli MIC 128.0 ug.mL-1 10.1128/aac.01655-08
Campylobacter coli Campylobacter coli MIC50 64.0 ug.mL-1 10.1128/aac.01655-08
Campylobacter coli Campylobacter coli MIC90 128.0 ug.mL-1 10.1128/aac.01655-08
Campylobacter jejuni Campylobacter jejuni MIC 0.12 ug.mL-1 10.1128/aac.01655-08
Campylobacter jejuni Campylobacter jejuni MIC 1.0 ug.mL-1 10.1128/aac.01655-08
Campylobacter jejuni Campylobacter jejuni MIC 4.0 ug.mL-1 10.1128/aac.01655-08
Campylobacter jejuni Campylobacter jejuni MIC 32.0 ug.mL-1 10.1128/aac.01655-08
Campylobacter jejuni Campylobacter jejuni MIC 64.0 ug.mL-1 10.1128/aac.01655-08
Campylobacter jejuni Campylobacter jejuni MIC 128.0 ug.mL-1 10.1128/aac.01655-08
Campylobacter jejuni Campylobacter jejuni MIC50 64.0 ug.mL-1 10.1128/aac.01655-08
Campylobacter jejuni Campylobacter jejuni MIC90 128.0 ug.mL-1 10.1128/aac.01655-08
Canis lupus familiaris Canis familiaris AUC 13000.0 ng.hr.mL-1 10.1016/j.bmcl.2018.01.006
Canis lupus familiaris Canis familiaris CL 4.0 mL.min-1.kg-1 10.1016/j.bmcl.2018.01.006
Canis lupus familiaris Canis familiaris Drugexcretion 53.0 %ID 10.1016/j.bmcl.2018.01.006
Canis lupus familiaris Canis familiaris T1/2 0.7 hr 10.1016/j.bmcl.2018.01.006
Canis lupus familiaris Canis familiaris Vd 0.2 L.kg-1 10.1016/j.bmcl.2018.01.006
Carnobacterium divergens Carnobacterium divergens MIC 256.0 ug.mL-1 10.1128/aac.01145-07
Carnobacterium divergens Carnobacterium divergens MIC nan None 10.1128/aac.01145-07
Caulobacter vibrioides Metallo-beta-lactamase Kcat/Km nan None 10.1128/aac.01062-07
Cavia porcellus Leukotriene C4 synthase IC50 nan None None
Cavia porcellus Leukotriene C4 synthase Ki nan None None
Cavia porcellus Serotonin 4 (5-HT4) receptor IC50 nan None None
Cavia porcellus Serotonin 4 (5-HT4) receptor Ki nan None None
Chryseobacterium indologenes Chryseobacterium indologenes Activity 32.0 ug ml-1 10.1128/aac.00083-07
Chryseobacterium indologenes Chryseobacterium indologenes MIC nan None 10.1128/aac.01607-08
Chryseobacterium indologenes IND-like metallo-beta-lactamase Kcat/Km nan None 10.1128/aac.01607-08
Chryseobacterium indologenes Metallo-beta-lactamase IND-2 Kcat/Km nan None 10.1128/aac.01607-08
Chryseobacterium indologenes Metallo-beta-lactamase IND-6 Kcat nan None 10.1128/aac.01607-08
Chryseobacterium indologenes Metallo-beta-lactamase IND-6 Kcat/Km nan None 10.1128/aac.01607-08
Chryseobacterium indologenes Metallo-beta-lactamase IND-6 Km nan None 10.1128/aac.01607-08
Citrobacter amalonaticus Citrobacter amalonaticus MIC 1.0 ug.mL-1 10.1128/aac.01634-07
Citrobacter amalonaticus Citrobacter amalonaticus MIC 16.0 ug.mL-1 10.1128/aac.01634-07
Citrobacter freundii Citrobacter freundii MIC 0.125 ug.mL-1 10.1016/j.ejmech.2016.01.024
Citrobacter freundii Citrobacter freundii MIC 0.25 ug.mL-1 10.1128/aac.01337-07
Citrobacter freundii Citrobacter freundii MIC 2.0 ug.mL-1 10.1016/j.ejmech.2010.10.007
Citrobacter freundii Citrobacter freundii MIC 4.0 ug.mL-1 10.1128/aac.01790-09
Citrobacter freundii Citrobacter freundii MIC 16.0 ug.mL-1 10.1128/aac.01634-07
Citrobacter freundii Citrobacter freundii MIC 32.0 ug.mL-1 10.1128/aac.01525-09
Citrobacter freundii Citrobacter freundii MIC 100.0 nM 10.1021/acs.jmedchem.7b01164
Citrobacter freundii Citrobacter freundii MIC 128.0 ug.mL-1 10.1128/aac.01405-06
Citrobacter freundii Citrobacter freundii MIC 256.0 ug.mL-1 10.1128/aac.01395-06
Citrobacter freundii Citrobacter freundii MIC 512.0 ug.mL-1 10.1128/aac.01312-09
Citrobacter freundii Citrobacter freundii MIC50 0.25 ug.mL-1 10.1021/ml200012f
Citrobacter freundii Citrobacter freundii MIC50 32.0 ug.mL-1 10.1128/aac.01525-09
Citrobacter freundii Citrobacter freundii MIC90 32.0 ug.mL-1 10.1128/aac.01525-09
Citrobacter freundii Citrobacter freundii MIC90 64.0 ug.mL-1 10.1021/jm2014748
Citrobacter freundii Citrobacter freundii MIC90 64.0 ug.mL-1 10.1021/jm2014875
Citrobacter freundii Citrobacter freundii MIC90 64.0 ug.mL-1 10.1021/ml200012f
Citrobacter freundii PER-2 beta-lactamase Activity 18.0 % 10.1128/aac.01395-06
Citrobacter freundii PER-2 beta-lactamase Kcat 0.23 /s 10.1128/aac.01395-06
Citrobacter freundii PER-2 beta-lactamase Kcat/Km 0.12 /uM/s 10.1128/aac.01395-06
Citrobacter freundii PER-2 beta-lactamase Ki 2000.0 nM 10.1128/aac.01395-06
Citrobacter gillenii Gil1 Kcat 0.8 /s 10.1128/aac.01152-06
Citrobacter gillenii Gil1 Kcat/Km 1.0 /mM/s 10.1128/aac.01152-06
Citrobacter gillenii Gil1 Km 938000.0 nM 10.1128/aac.01152-06
Citrobacter gillenii Gil1 Ratio 0.02 None 10.1128/aac.01152-06
Citrobacter koseri Citrobacter koseri MIC 0.03 ug.mL-1 10.1021/jm00128a014
Citrobacter koseri Citrobacter koseri MIC 1.0 ug.mL-1 10.1128/aac.01634-07
Clostridium perfringens Clostridium perfringens MIC 256.0 ug.mL-1 10.1016/S0960-894X(01)80932-X
Cutibacterium acnes Cutibacterium acnes MIC 2.0 ug.mL-1 10.1016/S0960-894X(01)80932-X
Elizabethkingia meningoseptica GOB-1 metallo-beta-lactamase Kcat/Km nan None 10.1128/aac.01062-07
Enterobacter Enterobacter MIC 2.0 ug.mL-1 10.1128/aac.01614-06
Enterobacter Enterobacter MIC 16.0 ug.mL-1 10.1128/aac.01614-06
Enterobacter Enterobacter MIC 64.0 ug.mL-1 10.1128/aac.01614-06
Enterobacter cloacae Enterobacter cloacae Activity 47.1 % 10.1128/aac.01195-06
Enterobacter cloacae Enterobacter cloacae Activity 77.9 % 10.1128/aac.01195-06
Enterobacter cloacae Enterobacter cloacae Activity 85.5 % 10.1128/aac.01195-06
Enterobacter cloacae Enterobacter cloacae Inhibition nan % 10.1128/aac.01452-08
Enterobacter cloacae Enterobacter cloacae MBC 0.125 ug ml-1 10.1128/aac.01452-08
Enterobacter cloacae Enterobacter cloacae MBC 16.0 ug ml-1 10.1128/aac.01452-08
Enterobacter cloacae Enterobacter cloacae MBC 64.0 ug ml-1 10.1128/aac.01452-08
Enterobacter cloacae Enterobacter cloacae MIC 0.06 ug.mL-1 10.1021/jm00128a014
Enterobacter cloacae Enterobacter cloacae MIC 0.06 ug.mL-1 10.1128/aac.01525-09
Enterobacter cloacae Enterobacter cloacae MIC 0.12 ug.mL-1 10.1021/jm00128a014
Enterobacter cloacae Enterobacter cloacae MIC 0.12 ug.mL-1 10.1128/aac.01082-06
Enterobacter cloacae Enterobacter cloacae MIC 0.125 ug.mL-1 10.1128/aac.01452-08
Enterobacter cloacae Enterobacter cloacae MIC 0.25 ug.mL-1 10.1016/j.ejmech.2016.01.024
Enterobacter cloacae Enterobacter cloacae MIC 1.0 ug.mL-1 10.1128/aac.01634-07
Enterobacter cloacae Enterobacter cloacae MIC 2.0 ug.mL-1 10.1016/j.ejmech.2010.10.007
Enterobacter cloacae Enterobacter cloacae MIC 2.0 ug.mL-1 10.1128/aac.00072-07
Enterobacter cloacae Enterobacter cloacae MIC 4.0 ug.mL-1 10.1021/jm00128a014
Enterobacter cloacae Enterobacter cloacae MIC 8.0 ug.mL-1 10.1128/aac.00707-08
Enterobacter cloacae Enterobacter cloacae MIC 8.0 ug.mL-1 10.1128/aac.01452-08
Enterobacter cloacae Enterobacter cloacae MIC 16.0 ug.mL-1 10.1128/aac.01634-07
Enterobacter cloacae Enterobacter cloacae MIC 32.0 ug.mL-1 10.1128/aac.01452-08
Enterobacter cloacae Enterobacter cloacae MIC 32.0 ug.mL-1 10.1128/aac.01525-09
Enterobacter cloacae Enterobacter cloacae MIC 64.0 ug.mL-1 10.1016/j.bmc.2022.116722
Enterobacter cloacae Enterobacter cloacae MIC 64.0 ug.mL-1 10.1016/j.bmcl.2021.127878
Enterobacter cloacae Enterobacter cloacae MIC 64.0 ug.mL-1 10.1128/aac.00072-07
Enterobacter cloacae Enterobacter cloacae MIC 64.0 ug.mL-1 10.1128/aac.01341-07
Enterobacter cloacae Enterobacter cloacae MIC 128.0 ug.mL-1 10.1016/j.ejmech.2018.03.031
Enterobacter cloacae Enterobacter cloacae MIC 128.0 ug.mL-1 10.1128/aac.00072-07
Enterobacter cloacae Enterobacter cloacae MIC 256.0 ug.mL-1 10.1128/aac.00072-07
Enterobacter cloacae Enterobacter cloacae MIC 256.0 ug.mL-1 10.1128/aac.00163-08
Enterobacter cloacae Enterobacter cloacae MIC 512.0 ug.mL-1 10.1128/aac.01312-09
Enterobacter cloacae Enterobacter cloacae MIC50 1.0 ug.mL-1 10.1128/aac.01525-09
Enterobacter cloacae Enterobacter cloacae MIC90 32.0 ug.mL-1 10.1128/aac.01525-09
Enterobacter cloacae IMI-1 Kcat 51.0 /s 10.1128/aac.00491-07
Enterobacter cloacae IMI-1 Kcat/Km 550.0 /mM/s 10.1128/aac.00491-07
Enterobacter cloacae IMI-1 Km 93000.0 nM 10.1128/aac.00491-07
Enterobacteriaceae Enterobacteriaceae Activity 9.4 % 10.1128/aac.00044-07
Enterobacteriaceae Enterobacteriaceae Activity 26.9 % 10.1128/aac.00044-07
Enterobacteriaceae Enterobacteriaceae Activity 32.1 % 10.1128/aac.01114-07
Enterobacteriaceae Enterobacteriaceae Activity 78.6 % 10.1128/aac.01114-07
Enterobacteriaceae Enterobacteriaceae MIC50 16.0 ug.mL-1 10.1128/aac.01114-07
Enterobacteriaceae Enterobacteriaceae MIC90 16.0 ug.mL-1 10.1128/aac.01114-07
Enterobacteriaceae Enterobacteriaceae MIC90 64.0 ug.mL-1 10.1016/j.bmcl.2018.01.006
Enterobacter sp. Enterobacter sp. Activity 28.6 % 10.1128/aac.01114-07
Enterobacter sp. Enterobacter sp. Activity 57.1 % 10.1128/aac.01114-07
Enterobacter sp. Enterobacter sp. MIC50 16.0 ug.mL-1 10.1128/aac.01114-07
Enterobacter sp. Enterobacter sp. MIC90 16.0 ug.mL-1 10.1128/aac.01114-07
Enterococcus faecium Enterococcus faecium MIC 64.0 ug.mL-1 10.1128/aac.01790-09
Escherichia coli AmpC IC50 60.0 nM 10.1128/aac.01525-09
Escherichia coli AmpC Kcat 6e-05 /s 10.1128/aac.01525-09
Escherichia coli AmpC Kcat/Km 2.9 /M/s 10.1128/aac.01525-09
Escherichia coli AmpC Km 21000.0 nM 10.1128/aac.01525-09
Escherichia coli Beta-lactamase ACC-4 IC50 32.0 nM 10.1128/aac.00389-07
Escherichia coli Beta-lactamase CTX-M-16 Km 17000.0 nM 10.1128/aac.01581-08
Escherichia coli Beta-lactamase CTX-M-27 Km 17000.0 nM 10.1128/aac.01581-08
Escherichia coli Beta-lactamase SHV-1 Kcat nan None 10.1128/aac.01442-09
Escherichia coli Beta-lactamase SHV-1 Kcat/Km nan None 10.1128/aac.01442-09
Escherichia coli Beta-lactamase SHV-1 Km nan None 10.1128/aac.01442-09
Escherichia coli Beta-lactamase SHV-11 Kcat 0.01 /s 10.1128/aac.00387-08
Escherichia coli Beta-lactamase SHV-11 Kcat/Km nan None 10.1128/aac.00387-08
Escherichia coli Beta-lactamase SHV-11 Km nan None 10.1128/aac.00387-08
Escherichia coli Beta-lactamase SHV-12 Stability nan % 10.1016/j.bmcl.2018.01.006
Escherichia coli Beta-lactamase TEM Kcat 0.1 /s 10.1128/aac.00614-07
Escherichia coli Beta-lactamase TEM Kcat/Km nan None 10.1128/aac.00614-07
Escherichia coli Beta-lactamase TEM Km nan None 10.1128/aac.00614-07
Escherichia coli Beta-lactamase Toho-1 Kcat 8.3 /s 10.1128/aac.00098-10
Escherichia coli Beta-lactamase Toho-1 Kcat/Km 1.9 10'5/s/M 10.1128/aac.00098-10
Escherichia coli Beta-lactamase Toho-1 Km 45000.0 nM 10.1128/aac.00098-10
Escherichia coli BlaVIM-1 Kcat 0.01 /s 10.1128/aac.00017-09
Escherichia coli BlaVIM-1 Kcat 0.01 /s 10.1128/aac.00458-09
Escherichia coli BlaVIM-1 Kcat/Km 0.0001 /uM/s 10.1128/aac.00458-09
Escherichia coli BlaVIM-1 Km 1000000.0 nM 10.1128/aac.00458-09
Escherichia coli Cell shape peptidoglycan synthetase penicillin-binding protein 2 IC50 8.0 ug.mL-1 10.1128/aac.00029-07
Escherichia coli CMT-type beta lactamase Kcat 0.06 /s 10.1128/aac.00614-07
Escherichia coli CMT-type beta lactamase Kcat/Km 0.0008 None 10.1128/aac.00614-07
Escherichia coli CMT-type beta lactamase Km 75.6 /s/microM 10.1128/aac.00614-07
Escherichia coli Escherichia coli Activity 0.0 % 10.1128/aac.00551-10
Escherichia coli Escherichia coli Activity 0.125 ug ml-1 10.1128/aac.00083-07
Escherichia coli Escherichia coli Activity 11.0 % 10.1128/aac.01412-06
Escherichia coli Escherichia coli Activity 22.0 % 10.1128/aac.01412-06
Escherichia coli Escherichia coli Activity 46.1 % 10.1128/aac.01509-06
Escherichia coli Escherichia coli Activity 100.0 % 10.1128/aac.01412-06
Escherichia coli Escherichia coli Activity nan None 10.1016/j.bmcl.2016.10.004
Escherichia coli Escherichia coli Activity nan None 10.1128/aac.00614-07
Escherichia coli Escherichia coli Activity nan None 10.1128/aac.01525-09
Escherichia coli Escherichia coli Activity nan None 10.1128/aac.01677-09
Escherichia coli Escherichia coli Inhibition nan % 10.1128/aac.01452-08
Escherichia coli Escherichia coli MBC 0.125 ug ml-1 10.1128/aac.01452-08
Escherichia coli Escherichia coli MBC 0.25 ug ml-1 10.1128/aac.01452-08
Escherichia coli Escherichia coli MBC 32.0 ug ml-1 10.1128/aac.01452-08
Escherichia coli Escherichia coli MIC 0.015 ug.mL-1 10.1128/aac.01442-09
Escherichia coli Escherichia coli MIC 0.016 ug.mL-1 10.1128/aac.00163-08
Escherichia coli Escherichia coli MIC 0.016 ug.mL-1 10.1128/aac.00175-08
Escherichia coli Escherichia coli MIC 0.016 ug.mL-1 10.1128/aac.01145-07
Escherichia coli Escherichia coli MIC 0.016 ug.mL-1 10.1128/aac.01395-06
Escherichia coli Escherichia coli MIC 0.02 ug.mL-1 10.1128/aac.01451-07
Escherichia coli Escherichia coli MIC 0.023 ug.mL-1 10.1128/aac.01473-08
Escherichia coli Escherichia coli MIC 0.03 ug.mL-1 10.1128/aac.00461-09
Escherichia coli Escherichia coli MIC 0.03 ug.mL-1 10.1128/aac.00543-08
Escherichia coli Escherichia coli MIC 0.03 ug.mL-1 10.1128/aac.01180-07
Escherichia coli Escherichia coli MIC 0.03 ug.mL-1 10.1128/aac.01312-09
Escherichia coli Escherichia coli MIC 0.03 ug.mL-1 10.1128/aac.01442-09
Escherichia coli Escherichia coli MIC 0.03 ug.mL-1 10.1128/aac.01451-07
Escherichia coli Escherichia coli MIC 0.031 ug.mL-1 10.1128/aac.01337-07
Escherichia coli Escherichia coli MIC 0.032 ug.mL-1 10.1128/aac.00771-10
Escherichia coli Escherichia coli MIC 0.032 ug.mL-1 10.1128/aac.00912-08
Escherichia coli Escherichia coli MIC 0.032 ug.mL-1 10.1128/aac.01011-08
Escherichia coli Escherichia coli MIC 0.032 ug.mL-1 10.1128/aac.01615-09
Escherichia coli Escherichia coli MIC 0.047 ug.mL-1 10.1128/aac.00050-10
Escherichia coli Escherichia coli MIC 0.047 ug.mL-1 10.1128/aac.00163-08
Escherichia coli Escherichia coli MIC 0.047 ug.mL-1 10.1128/aac.00912-08
Escherichia coli Escherichia coli MIC 0.05 ug.mL-1 10.1016/j.ejmech.2012.03.008
Escherichia coli Escherichia coli MIC 0.06 ug.mL-1 10.1021/jm00128a014
Escherichia coli Escherichia coli MIC 0.06 ug.mL-1 10.1128/aac.00389-07
Escherichia coli Escherichia coli MIC 0.06 ug.mL-1 10.1128/aac.00427-09
Escherichia coli Escherichia coli MIC 0.06 ug.mL-1 10.1128/aac.00608-08
Escherichia coli Escherichia coli MIC 0.06 ug.mL-1 10.1128/aac.00638-08
Escherichia coli Escherichia coli MIC 0.06 ug.mL-1 10.1128/aac.00791-09
Escherichia coli Escherichia coli MIC 0.06 ug.mL-1 10.1128/aac.00946-08
Escherichia coli Escherichia coli MIC 0.06 ug.mL-1 10.1128/aac.00978-07
Escherichia coli Escherichia coli MIC 0.06 ug.mL-1 10.1128/aac.01152-06
Escherichia coli Escherichia coli MIC 0.06 ug.mL-1 10.1128/aac.01312-09
Escherichia coli Escherichia coli MIC 0.06 ug.mL-1 10.1128/aac.01381-07
Escherichia coli Escherichia coli MIC 0.06 ug.mL-1 10.1128/aac.01412-06
Escherichia coli Escherichia coli MIC 0.06 ug.mL-1 10.1128/aac.01581-08
Escherichia coli Escherichia coli MIC 0.063 ug.mL-1 10.1128/aac.01337-07
Escherichia coli Escherichia coli MIC 0.063 ug.mL-1 10.1128/aac.01677-09
Escherichia coli Escherichia coli MIC 0.064 ug.mL-1 10.1128/aac.00133-09
Escherichia coli Escherichia coli MIC 0.064 ug.mL-1 10.1128/aac.00167-07
Escherichia coli Escherichia coli MIC 0.064 ug.mL-1 10.1128/aac.00543-08
Escherichia coli Escherichia coli MIC 0.064 ug.mL-1 10.1128/aac.00774-09
Escherichia coli Escherichia coli MIC 0.094 ug.mL-1 10.1128/aac.00050-10
Escherichia coli Escherichia coli MIC 0.094 ug.mL-1 10.1128/aac.00374-07
Escherichia coli Escherichia coli MIC 0.094 ug.mL-1 10.1128/aac.00771-10
Escherichia coli Escherichia coli MIC 0.094 ug.mL-1 10.1128/aac.00774-09
Escherichia coli Escherichia coli MIC 0.094 ug.mL-1 10.1128/aac.00912-08
Escherichia coli Escherichia coli MIC 0.12 ug.mL-1 10.1128/aac.00017-09
Escherichia coli Escherichia coli MIC 0.12 ug.mL-1 10.1128/aac.00029-07
Escherichia coli Escherichia coli MIC 0.12 ug.mL-1 10.1128/aac.00219-09
Escherichia coli Escherichia coli MIC 0.12 ug.mL-1 10.1128/aac.00393-08
Escherichia coli Escherichia coli MIC 0.12 ug.mL-1 10.1128/aac.00458-09
Escherichia coli Escherichia coli MIC 0.12 ug.mL-1 10.1128/aac.00614-07
Escherichia coli Escherichia coli MIC 0.12 ug.mL-1 10.1128/aac.00638-08
Escherichia coli Escherichia coli MIC 0.12 ug.mL-1 10.1128/aac.00734-08
Escherichia coli Escherichia coli MIC 0.12 ug.mL-1 10.1128/aac.00736-08
Escherichia coli Escherichia coli MIC 0.12 ug.mL-1 10.1128/aac.00768-10
Escherichia coli Escherichia coli MIC 0.12 ug.mL-1 10.1128/aac.00858-10
Escherichia coli Escherichia coli MIC 0.12 ug.mL-1 10.1128/aac.00859-09
Escherichia coli Escherichia coli MIC 0.12 ug.mL-1 10.1128/aac.00878-10
Escherichia coli Escherichia coli MIC 0.12 ug.mL-1 10.1128/aac.00909-06
Escherichia coli Escherichia coli MIC 0.12 ug.mL-1 10.1128/aac.00978-07
Escherichia coli Escherichia coli MIC 0.12 ug.mL-1 10.1128/aac.01058-06
Escherichia coli Escherichia coli MIC 0.12 ug.mL-1 10.1128/aac.01082-06
Escherichia coli Escherichia coli MIC 0.12 ug.mL-1 10.1128/aac.01152-06
Escherichia coli Escherichia coli MIC 0.12 ug.mL-1 10.1128/aac.01312-09
Escherichia coli Escherichia coli MIC 0.12 ug.mL-1 10.1128/aac.01336-09
Escherichia coli Escherichia coli MIC 0.12 ug.mL-1 10.1128/aac.01439-06
Escherichia coli Escherichia coli MIC 0.12 ug.mL-1 10.1128/aac.01456-09
Escherichia coli Escherichia coli MIC 0.12 ug.mL-1 10.1128/aac.01463-07
Escherichia coli Escherichia coli MIC 0.12 ug.mL-1 10.1128/aac.01529-07
Escherichia coli Escherichia coli MIC 0.12 ug.mL-1 10.1128/aac.01561-09
Escherichia coli Escherichia coli MIC 0.12 ug.mL-1 10.1128/aac.01600-06
Escherichia coli Escherichia coli MIC 0.125 ug.mL-1 10.1016/j.bmcl.2018.01.006
Escherichia coli Escherichia coli MIC 0.125 ug.mL-1 10.1016/j.ejmech.2016.01.024
Escherichia coli Escherichia coli MIC 0.125 ug.mL-1 10.1021/jm500219c
Escherichia coli Escherichia coli MIC 0.125 ug.mL-1 10.1128/aac.00050-10
Escherichia coli Escherichia coli MIC 0.125 ug.mL-1 10.1128/aac.00072-09
Escherichia coli Escherichia coli MIC 0.125 ug.mL-1 10.1128/aac.00098-10
Escherichia coli Escherichia coli MIC 0.125 ug.mL-1 10.1128/aac.00465-08
Escherichia coli Escherichia coli MIC 0.125 ug.mL-1 10.1128/aac.00608-08
Escherichia coli Escherichia coli MIC 0.125 ug.mL-1 10.1128/aac.00688-09
Escherichia coli Escherichia coli MIC 0.125 ug.mL-1 10.1128/aac.00912-08
Escherichia coli Escherichia coli MIC 0.125 ug.mL-1 10.1128/aac.01028-07
Escherichia coli Escherichia coli MIC 0.125 ug.mL-1 10.1128/aac.01053-06
Escherichia coli Escherichia coli MIC 0.125 ug.mL-1 10.1128/aac.01155-08
Escherichia coli Escherichia coli MIC 0.125 ug.mL-1 10.1128/aac.01252-09
Escherichia coli Escherichia coli MIC 0.125 ug.mL-1 10.1128/aac.01381-07
Escherichia coli Escherichia coli MIC 0.125 ug.mL-1 10.1128/aac.01442-09
Escherichia coli Escherichia coli MIC 0.125 ug.mL-1 10.1128/aac.01452-08
Escherichia coli Escherichia coli MIC 0.125 ug.mL-1 10.1128/aac.01525-09
Escherichia coli Escherichia coli MIC 0.125 ug.mL-1 10.1128/aac.01539-07
Escherichia coli Escherichia coli MIC 0.125 ug.mL-1 10.1128/aac.01672-07
Escherichia coli Escherichia coli MIC 0.19 ug.mL-1 10.1128/aac.00465-08
Escherichia coli Escherichia coli MIC 0.19 ug.mL-1 10.1128/aac.00684-07
Escherichia coli Escherichia coli MIC 0.19 ug.mL-1 10.1128/aac.00912-08
Escherichia coli Escherichia coli MIC 0.25 ug.mL-1 10.1128/aac.00227-08
Escherichia coli Escherichia coli MIC 0.25 ug.mL-1 10.1128/aac.00688-09
Escherichia coli Escherichia coli MIC 0.25 ug.mL-1 10.1128/aac.00774-09
Escherichia coli Escherichia coli MIC 0.25 ug.mL-1 10.1128/aac.00878-10
Escherichia coli Escherichia coli MIC 0.25 ug.mL-1 10.1128/aac.00912-08
Escherichia coli Escherichia coli MIC 0.25 ug.mL-1 10.1128/aac.00961-09
Escherichia coli Escherichia coli MIC 0.25 ug.mL-1 10.1128/aac.01025-07
Escherichia coli Escherichia coli MIC 0.25 ug.mL-1 10.1128/aac.01062-07
Escherichia coli Escherichia coli MIC 0.25 ug.mL-1 10.1128/aac.01155-08
Escherichia coli Escherichia coli MIC 0.25 ug.mL-1 10.1128/aac.01452-08
Escherichia coli Escherichia coli MIC 0.25 ug.mL-1 10.1128/aac.01456-09
Escherichia coli Escherichia coli MIC 0.25 ug.mL-1 10.1128/aac.01581-08
Escherichia coli Escherichia coli MIC 0.25 ug.mL-1 10.1128/aac.01585-09
Escherichia coli Escherichia coli MIC 0.25 ug.mL-1 10.1128/aac.01607-08
Escherichia coli Escherichia coli MIC 0.25 ug.mL-1 10.1128/aac.01677-09
Escherichia coli Escherichia coli MIC 0.32 ug.mL-1 10.1128/aac.01451-07
Escherichia coli Escherichia coli MIC 0.5 ug.mL-1 10.1016/j.ejmech.2018.03.058
Escherichia coli Escherichia coli MIC 0.5 ug.mL-1 10.1021/acs.jmedchem.6b01261
Escherichia coli Escherichia coli MIC 0.5 ug.mL-1 10.1128/aac.00374-07
Escherichia coli Escherichia coli MIC 0.5 ug.mL-1 10.1128/aac.00389-07
Escherichia coli Escherichia coli MIC 0.5 ug.mL-1 10.1128/aac.00946-08
Escherichia coli Escherichia coli MIC 0.5 ug.mL-1 10.1128/aac.01025-07
Escherichia coli Escherichia coli MIC 0.5 ug.mL-1 10.1128/aac.01155-08
Escherichia coli Escherichia coli MIC 0.5 ug.mL-1 10.1128/aac.01615-09
Escherichia coli Escherichia coli MIC 0.5 ug.mL-1 10.1128/aac.01672-07
Escherichia coli Escherichia coli MIC 0.75 ug.mL-1 10.1128/aac.00072-09
Escherichia coli Escherichia coli MIC 1.0 ug.mL-1 10.1016/j.bmcl.2018.01.006
Escherichia coli Escherichia coli MIC 1.0 ug.mL-1 10.1016/j.bmcl.2021.127878
Escherichia coli Escherichia coli MIC 1.0 ug.mL-1 10.1128/aac.00098-10
Escherichia coli Escherichia coli MIC 1.0 ug.mL-1 10.1128/aac.00158-08
Escherichia coli Escherichia coli MIC 1.0 ug.mL-1 10.1128/aac.00299-07
Escherichia coli Escherichia coli MIC 1.0 ug.mL-1 10.1128/aac.00374-07
Escherichia coli Escherichia coli MIC 1.0 ug.mL-1 10.1128/aac.00389-07
Escherichia coli Escherichia coli MIC 1.0 ug.mL-1 10.1128/aac.00614-07
Escherichia coli Escherichia coli MIC 1.0 ug.mL-1 10.1128/aac.00896-08
Escherichia coli Escherichia coli MIC 1.0 ug.mL-1 10.1128/aac.01252-09
Escherichia coli Escherichia coli MIC 1.0 ug.mL-1 10.1128/aac.01341-07
Escherichia coli Escherichia coli MIC 1.0 ug.mL-1 10.1128/aac.01359-09
Escherichia coli Escherichia coli MIC 1.0 ug.mL-1 10.1128/aac.01439-06
Escherichia coli Escherichia coli MIC 1.0 ug.mL-1 10.1128/aac.01462-06
Escherichia coli Escherichia coli MIC 1.0 ug.mL-1 10.1128/aac.01561-09
Escherichia coli Escherichia coli MIC 1.0 ug.mL-1 10.1128/aac.01634-07
Escherichia coli Escherichia coli MIC 1.0 ug.mL-1 10.1128/aac.01790-09
Escherichia coli Escherichia coli MIC 1.0 ug.mL-1 10.1128/aac.01818-09
Escherichia coli Escherichia coli MIC 1.5 ug.mL-1 10.1128/aac.01451-07
Escherichia coli Escherichia coli MIC 2.0 ug.mL-1 10.1016/j.ejmech.2010.10.007
Escherichia coli Escherichia coli MIC 2.0 ug.mL-1 10.1016/j.ejmech.2018.03.058
Escherichia coli Escherichia coli MIC 2.0 ug.mL-1 10.1128/aac.00050-10
Escherichia coli Escherichia coli MIC 2.0 ug.mL-1 10.1128/aac.00098-10
Escherichia coli Escherichia coli MIC 2.0 ug.mL-1 10.1128/aac.00158-08
Escherichia coli Escherichia coli MIC 2.0 ug.mL-1 10.1128/aac.00167-07
Escherichia coli Escherichia coli MIC 2.0 ug.mL-1 10.1128/aac.00389-07
Escherichia coli Escherichia coli MIC 2.0 ug.mL-1 10.1128/aac.00427-09
Escherichia coli Escherichia coli MIC 2.0 ug.mL-1 10.1128/aac.00771-10
Escherichia coli Escherichia coli MIC 2.0 ug.mL-1 10.1128/aac.01058-06
Escherichia coli Escherichia coli MIC 2.0 ug.mL-1 10.1128/aac.01451-07
Escherichia coli Escherichia coli MIC 4.0 ug.mL-1 10.1016/j.bmcl.2018.01.006
Escherichia coli Escherichia coli MIC 4.0 ug.mL-1 10.1016/j.bmcl.2021.127878
Escherichia coli Escherichia coli MIC 4.0 ug.mL-1 10.1016/j.ejmech.2018.03.058
Escherichia coli Escherichia coli MIC 4.0 ug.mL-1 10.1128/aac.00017-09
Escherichia coli Escherichia coli MIC 4.0 ug.mL-1 10.1128/aac.00133-09
Escherichia coli Escherichia coli MIC 4.0 ug.mL-1 10.1128/aac.00458-09
Escherichia coli Escherichia coli MIC 4.0 ug.mL-1 10.1128/aac.00614-07
Escherichia coli Escherichia coli MIC 4.0 ug.mL-1 10.1128/aac.01058-06
Escherichia coli Escherichia coli MIC 6.0 ug.mL-1 10.1128/aac.00050-10
Escherichia coli Escherichia coli MIC 6.0 ug.mL-1 10.1128/aac.00133-09
Escherichia coli Escherichia coli MIC 8.0 ug.mL-1 10.1016/j.bmcl.2018.01.006
Escherichia coli Escherichia coli MIC 8.0 ug.mL-1 10.1016/j.ejmech.2016.01.024
Escherichia coli Escherichia coli MIC 8.0 ug.mL-1 10.1016/j.ejmech.2019.02.024
Escherichia coli Escherichia coli MIC 8.0 ug.mL-1 10.1128/aac.00050-10
Escherichia coli Escherichia coli MIC 8.0 ug.mL-1 10.1128/aac.00098-10
Escherichia coli Escherichia coli MIC 8.0 ug.mL-1 10.1128/aac.00133-09
Escherichia coli Escherichia coli MIC 8.0 ug.mL-1 10.1128/aac.00163-08
Escherichia coli Escherichia coli MIC 8.0 ug.mL-1 10.1128/aac.00461-09
Escherichia coli Escherichia coli MIC 8.0 ug.mL-1 10.1128/aac.00688-09
Escherichia coli Escherichia coli MIC 8.0 ug.mL-1 10.1128/aac.01058-06
Escherichia coli Escherichia coli MIC 8.0 ug.mL-1 10.1128/aac.01412-06
Escherichia coli Escherichia coli MIC 8.0 ug.mL-1 10.1128/aac.01451-07
Escherichia coli Escherichia coli MIC 8.0 ug.mL-1 10.1128/aac.01452-08
Escherichia coli Escherichia coli MIC 8.0 ug.mL-1 10.1128/aac.01561-09
Escherichia coli Escherichia coli MIC 8.0 ug.mL-1 10.1128/aac.01672-07
Escherichia coli Escherichia coli MIC 12.0 ug.mL-1 10.1128/aac.01440-07
Escherichia coli Escherichia coli MIC 16.0 ug.mL-1 10.1016/j.bmcl.2018.01.006
Escherichia coli Escherichia coli MIC 16.0 ug.mL-1 10.1016/j.ejmech.2018.03.031
Escherichia coli Escherichia coli MIC 16.0 ug.mL-1 10.1016/j.ejmech.2018.03.058
Escherichia coli Escherichia coli MIC 16.0 ug.mL-1 10.1016/j.ejmech.2019.02.024
Escherichia coli Escherichia coli MIC 16.0 ug.mL-1 10.1128/aac.00017-09
Escherichia coli Escherichia coli MIC 16.0 ug.mL-1 10.1128/aac.00050-10
Escherichia coli Escherichia coli MIC 16.0 ug.mL-1 10.1128/aac.00098-10
Escherichia coli Escherichia coli MIC 16.0 ug.mL-1 10.1128/aac.00133-09
Escherichia coli Escherichia coli MIC 16.0 ug.mL-1 10.1128/aac.00219-09
Escherichia coli Escherichia coli MIC 16.0 ug.mL-1 10.1128/aac.00608-08
Escherichia coli Escherichia coli MIC 16.0 ug.mL-1 10.1128/aac.00638-08
Escherichia coli Escherichia coli MIC 16.0 ug.mL-1 10.1128/aac.00791-09
Escherichia coli Escherichia coli MIC 16.0 ug.mL-1 10.1128/aac.00859-09
Escherichia coli Escherichia coli MIC 16.0 ug.mL-1 10.1128/aac.00896-08
Escherichia coli Escherichia coli MIC 16.0 ug.mL-1 10.1128/aac.00961-09
Escherichia coli Escherichia coli MIC 16.0 ug.mL-1 10.1128/aac.01180-07
Escherichia coli Escherichia coli MIC 16.0 ug.mL-1 10.1128/aac.01451-07
Escherichia coli Escherichia coli MIC 16.0 ug.mL-1 10.1128/aac.01525-09
Escherichia coli Escherichia coli MIC 24.0 ug.mL-1 10.1128/aac.00072-09
Escherichia coli Escherichia coli MIC 24.0 ug.mL-1 10.1128/aac.00133-09
Escherichia coli Escherichia coli MIC 24.0 ug.mL-1 10.1128/aac.00163-08
Escherichia coli Escherichia coli MIC 24.0 ug.mL-1 10.1128/aac.00774-09
Escherichia coli Escherichia coli MIC 24.0 ug.mL-1 10.1128/aac.01451-07
Escherichia coli Escherichia coli MIC 32.0 ug.mL-1 10.1016/j.ejmech.2018.03.058
Escherichia coli Escherichia coli MIC 32.0 ug.mL-1 10.1128/aac.00638-08
Escherichia coli Escherichia coli MIC 32.0 ug.mL-1 10.1128/aac.00688-09
Escherichia coli Escherichia coli MIC 32.0 ug.mL-1 10.1128/aac.00736-08
Escherichia coli Escherichia coli MIC 32.0 ug.mL-1 10.1128/aac.01053-06
Escherichia coli Escherichia coli MIC 32.0 ug.mL-1 10.1128/aac.01341-07
Escherichia coli Escherichia coli MIC 32.0 ug.mL-1 10.1128/aac.01525-09
Escherichia coli Escherichia coli MIC 48.0 ug.mL-1 10.1128/aac.00072-09
Escherichia coli Escherichia coli MIC 64.0 ug.mL-1 10.1016/j.bmc.2022.116722
Escherichia coli Escherichia coli MIC 64.0 ug.mL-1 10.1016/j.bmcl.2018.01.006
Escherichia coli Escherichia coli MIC 64.0 ug.mL-1 10.1128/aac.00017-09
Escherichia coli Escherichia coli MIC 64.0 ug.mL-1 10.1128/aac.00098-10
Escherichia coli Escherichia coli MIC 64.0 ug.mL-1 10.1128/aac.00133-09
Escherichia coli Escherichia coli MIC 64.0 ug.mL-1 10.1128/aac.00158-08
Escherichia coli Escherichia coli MIC 64.0 ug.mL-1 10.1128/aac.00163-08
Escherichia coli Escherichia coli MIC 64.0 ug.mL-1 10.1128/aac.00227-08
Escherichia coli Escherichia coli MIC 64.0 ug.mL-1 10.1128/aac.00279-07
Escherichia coli Escherichia coli MIC 64.0 ug.mL-1 10.1128/aac.00461-09
Escherichia coli Escherichia coli MIC 64.0 ug.mL-1 10.1128/aac.00688-09
Escherichia coli Escherichia coli MIC 64.0 ug.mL-1 10.1128/aac.00878-10
Escherichia coli Escherichia coli MIC 64.0 ug.mL-1 10.1128/aac.01028-07
Escherichia coli Escherichia coli MIC 64.0 ug.mL-1 10.1128/aac.01053-06
Escherichia coli Escherichia coli MIC 64.0 ug.mL-1 10.1128/aac.01058-06
Escherichia coli Escherichia coli MIC 64.0 ug.mL-1 10.1128/aac.01341-07
Escherichia coli Escherichia coli MIC 64.0 ug.mL-1 10.1128/aac.01359-09
Escherichia coli Escherichia coli MIC 64.0 ug.mL-1 10.1128/aac.01412-06
Escherichia coli Escherichia coli MIC 64.0 ug.mL-1 10.1128/aac.01473-08
Escherichia coli Escherichia coli MIC 64.0 ug.mL-1 10.1128/aac.01672-07
Escherichia coli Escherichia coli MIC 100.0 nM 10.1021/acs.jmedchem.7b01164
Escherichia coli Escherichia coli MIC 128.0 ug.mL-1 10.1016/j.bmcl.2018.01.006
Escherichia coli Escherichia coli MIC 128.0 ug.mL-1 10.1016/j.ejmech.2018.03.031
Escherichia coli Escherichia coli MIC 128.0 ug.mL-1 10.1128/aac.00017-09
Escherichia coli Escherichia coli MIC 128.0 ug.mL-1 10.1128/aac.00098-10
Escherichia coli Escherichia coli MIC 128.0 ug.mL-1 10.1128/aac.00219-09
Escherichia coli Escherichia coli MIC 128.0 ug.mL-1 10.1128/aac.00734-08
Escherichia coli Escherichia coli MIC 128.0 ug.mL-1 10.1128/aac.00909-06
Escherichia coli Escherichia coli MIC 128.0 ug.mL-1 10.1128/aac.01155-08
Escherichia coli Escherichia coli MIC 128.0 ug.mL-1 10.1128/aac.01412-06
Escherichia coli Escherichia coli MIC 128.0 ug.mL-1 10.1128/aac.01473-08
Escherichia coli Escherichia coli MIC 128.0 ug.mL-1 10.1128/aac.01539-07
Escherichia coli Escherichia coli MIC 128.0 ug.mL-1 10.1128/aac.01581-08
Escherichia coli Escherichia coli MIC 192.0 ug.mL-1 10.1128/aac.01451-07
Escherichia coli Escherichia coli MIC 256.0 ug.mL-1 10.1016/j.bmcl.2018.01.006
Escherichia coli Escherichia coli MIC 256.0 ug.mL-1 10.1016/j.ejmech.2016.01.024
Escherichia coli Escherichia coli MIC 256.0 ug.mL-1 10.1128/aac.00050-10
Escherichia coli Escherichia coli MIC 256.0 ug.mL-1 10.1128/aac.01058-06
Escherichia coli Escherichia coli MIC 256.0 ug.mL-1 10.1128/aac.01395-06
Escherichia coli Escherichia coli MIC 256.0 ug.mL-1 10.1128/aac.01451-07
Escherichia coli Escherichia coli MIC 256.0 ug.mL-1 10.1128/aac.01462-06
Escherichia coli Escherichia coli MIC 256.0 ug.mL-1 10.1128/aac.01539-07
Escherichia coli Escherichia coli MIC 256.0 ug.mL-1 10.1128/aac.01585-09
Escherichia coli Escherichia coli MIC 512.0 ug.mL-1 10.1128/aac.01312-09
Escherichia coli Escherichia coli MIC 1024.0 ug.mL-1 10.1016/j.bmcl.2018.01.006
Escherichia coli Escherichia coli MIC 1024.0 ug.mL-1 10.1128/aac.00227-08
Escherichia coli Escherichia coli MIC 2048.0 ug.mL-1 10.1128/aac.01058-06
Escherichia coli Escherichia coli MIC nan ug.mL-1 10.1016/S0960-894X(01)80932-X
Escherichia coli Escherichia coli MIC nan None 10.1128/aac.00393-08
Escherichia coli Escherichia coli MIC50 1.0 ug.mL-1 10.1021/ml200012f
Escherichia coli Escherichia coli MIC50 2.0 ug.mL-1 10.1021/acs.jmedchem.0c00255
Escherichia coli Escherichia coli MIC50 4.0 ug.mL-1 10.1021/jm400560z
Escherichia coli Escherichia coli MIC50 8.0 ug.mL-1 10.1128/aac.01412-06
Escherichia coli Escherichia coli MIC50 16.0 ug.mL-1 10.1128/aac.01412-06
Escherichia coli Escherichia coli MIC50 32.0 ug.mL-1 10.1128/aac.01525-09
Escherichia coli Escherichia coli MIC50 64.0 ug.mL-1 10.1021/jm400560z
Escherichia coli Escherichia coli MIC50 256.0 ug.mL-1 10.1128/aac.01509-06
Escherichia coli Escherichia coli MIC90 16.0 ug.mL-1 10.1021/acs.jmedchem.0c00255
Escherichia coli Escherichia coli MIC90 16.0 ug.mL-1 10.1128/aac.01412-06
Escherichia coli Escherichia coli MIC90 32.0 ug.mL-1 10.1128/aac.01525-09
Escherichia coli Escherichia coli MIC90 64.0 ug.mL-1 10.1021/jm2014748
Escherichia coli Escherichia coli MIC90 64.0 ug.mL-1 10.1021/jm2014875
Escherichia coli Escherichia coli MIC90 64.0 ug.mL-1 10.1021/jm400560z
Escherichia coli Escherichia coli MIC90 64.0 ug.mL-1 10.1021/ml200012f
Escherichia coli Escherichia coli MIC90 256.0 ug.mL-1 10.1128/aac.01509-06
Escherichia coli Escherichia coli MIC90 512.0 ug.mL-1 10.1021/jm501506f
Escherichia coli Escherichia coli Ratio 1.0 None 10.1016/j.ejmech.2012.03.008
Escherichia coli Escherichia coli Ratio 16.0 None 10.1128/aac.00734-08
Escherichia coli Metallo-beta-lactamase Kcat 0.5 /s 10.1128/aac.00017-09
Escherichia coli Metallo-beta-lactamase VIM-19 Kcat nan None 10.1128/aac.00458-09
Escherichia coli Metallo-beta-lactamase VIM-19 Kcat/Km nan None 10.1128/aac.00458-09
Escherichia coli Metallo-beta-lactamase VIM-19 Km nan None 10.1128/aac.00458-09
Flavobacterium meningosepticum Carbapenem-hydrolyzing beta-lactamase BlaB-1 Kcat/Km nan None 10.1128/aac.01607-08
Fluoribacter gormanii FEZ-1 protein Kcat/Km nan None 10.1128/aac.01062-07
Fusobacterium nucleatum Fusobacterium nucleatum MIC 4.0 ug.mL-1 10.1016/S0960-894X(01)80932-X
Haemophilus influenzae Haemophilus influenzae MIC 0.12 ug.mL-1 10.1128/aac.01489-09
Homo sapiens Acetylcholinesterase AC50 400000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Acetylcholinesterase IC50 nan None None
Homo sapiens Acetylcholinesterase Ki nan None None
Homo sapiens Adenosine A1 receptor AC50 400000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Adenosine A1 receptor IC50 nan None None
Homo sapiens Adenosine A1 receptor Ki nan None None
Homo sapiens Adenosine A2a receptor AC50 400000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Adenosine A2a receptor IC50 nan None None
Homo sapiens Adenosine A2a receptor Ki nan None None
Homo sapiens Adenosine A3 receptor AC50 400000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Adenosine A3 receptor IC50 nan None None
Homo sapiens Adenosine A3 receptor Ki nan None None
Homo sapiens Alpha-1a adrenergic receptor AC50 400000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-1d adrenergic receptor IC50 nan None None
Homo sapiens Alpha-1d adrenergic receptor Ki nan None None
Homo sapiens Alpha-2a adrenergic receptor AC50 400000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-2a adrenergic receptor IC50 nan None None
Homo sapiens Alpha-2a adrenergic receptor Ki nan None None
Homo sapiens Alpha-2b adrenergic receptor AC50 400000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-2b adrenergic receptor IC50 nan None None
Homo sapiens Alpha-2b adrenergic receptor Ki nan None None
Homo sapiens Alpha-2c adrenergic receptor AC50 400000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-2c adrenergic receptor IC50 nan None None
Homo sapiens Alpha-2c adrenergic receptor Ki nan None None
Homo sapiens Angiotensin II type 2 (AT-2) receptor IC50 nan None None
Homo sapiens Angiotensin II type 2 (AT-2) receptor Ki nan None None
Homo sapiens Beta-1 adrenergic receptor AC50 400000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Beta-1 adrenergic receptor IC50 nan None None
Homo sapiens Beta-1 adrenergic receptor Ki nan None None
Homo sapiens Beta-2 adrenergic receptor AC50 400000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Beta-2 adrenergic receptor IC50 nan None None
Homo sapiens Beta-2 adrenergic receptor Ki nan None None
Homo sapiens Beta-3 adrenergic receptor IC50 nan None None
Homo sapiens Beta-3 adrenergic receptor Ki nan None None
Homo sapiens Bile salt export pump AC50 400000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Bradykinin B2 receptor IC50 nan None None
Homo sapiens Bradykinin B2 receptor Ki nan None None
Homo sapiens Calcitonin receptor IC50 nan None None
Homo sapiens Calcitonin receptor Ki nan None None
Homo sapiens Cannabinoid CB1 receptor AC50 400000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Cannabinoid CB1 receptor IC50 nan None None
Homo sapiens Cannabinoid CB1 receptor Ki nan None None
Homo sapiens Carbonic anhydrase II IC50 nan None None
Homo sapiens Carbonic anhydrase II Ki nan None None
Homo sapiens Caspase-1 IC50 nan None None
Homo sapiens Caspase-1 Ki nan None None
Homo sapiens Cathepsin G IC50 nan None None
Homo sapiens Cathepsin G Ki nan None None
Homo sapiens C-C chemokine receptor type 2 IC50 nan None None
Homo sapiens C-C chemokine receptor type 2 Ki nan None None
Homo sapiens C-C chemokine receptor type 4 IC50 nan None None
Homo sapiens C-C chemokine receptor type 4 Ki nan None None
Homo sapiens C-C chemokine receptor type 5 IC50 nan None None
Homo sapiens C-C chemokine receptor type 5 Ki nan None None
Homo sapiens Cholecystokinin A receptor AC50 400000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Cholecystokinin A receptor IC50 nan None None
Homo sapiens Cholecystokinin A receptor Ki nan None None
Homo sapiens Cyclooxygenase-1 IC50 nan None None
Homo sapiens Cyclooxygenase-1 Ki nan None None
Homo sapiens Cyclooxygenase-2 AC50 400000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Cyclooxygenase-2 IC50 nan None None
Homo sapiens Cyclooxygenase-2 Ki nan None None
Homo sapiens Cysteinyl leukotriene receptor 1 IC50 nan None None
Homo sapiens Cysteinyl leukotriene receptor 1 Ki nan None None
Homo sapiens Cytochrome P450 1A2 IC50 nan None None
Homo sapiens Cytochrome P450 1A2 Inhibition nan % 10.1021/tx300075j
Homo sapiens Cytochrome P450 1A2 Ki nan None None
Homo sapiens Cytochrome P450 2A6 IC50 nan None None
Homo sapiens Cytochrome P450 2A6 Ki nan None None
Homo sapiens Cytochrome P450 2C19 IC50 nan None None
Homo sapiens Cytochrome P450 2C19 Inhibition nan % 10.1021/tx300075j
Homo sapiens Cytochrome P450 2C19 Ki nan None None
Homo sapiens Cytochrome P450 2C9 IC50 nan None None
Homo sapiens Cytochrome P450 2C9 Inhibition nan % 10.1021/tx300075j
Homo sapiens Cytochrome P450 2C9 Ki nan None None
Homo sapiens Cytochrome P450 2D6 IC50 nan None None
Homo sapiens Cytochrome P450 2D6 Inhibition nan % 10.1021/tx300075j
Homo sapiens Cytochrome P450 2D6 Ki nan None None
Homo sapiens Cytochrome P450 2E1 IC50 nan None None
Homo sapiens Cytochrome P450 2E1 Ki nan None None
Homo sapiens Cytochrome P450 3A4 IC50 nan None None
Homo sapiens Cytochrome P450 3A4 Inhibition nan % 10.1021/tx300075j
Homo sapiens Cytochrome P450 3A4 Ki nan None None
Homo sapiens Delta opioid receptor AC50 400000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Delta opioid receptor IC50 nan None None
Homo sapiens Delta opioid receptor Ki nan None None
Homo sapiens Dopamine D1 receptor AC50 400000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine D1 receptor IC50 nan None None
Homo sapiens Dopamine D1 receptor Ki nan None None
Homo sapiens Dopamine D2 receptor AC50 400000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine D2 receptor IC50 nan None None
Homo sapiens Dopamine D2 receptor Ki nan None None
Homo sapiens Dopamine D3 receptor AC50 400000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine D3 receptor IC50 nan None None
Homo sapiens Dopamine D3 receptor Ki nan None None
Homo sapiens Dopamine D4 receptor IC50 nan None None
Homo sapiens Dopamine D4 receptor Ki nan None None
Homo sapiens Dopamine transporter AC50 400000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine transporter IC50 nan None None
Homo sapiens Dopamine transporter Ki nan None None
Homo sapiens Endothelin receptor ET-A AC50 400000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Endothelin receptor ET-A IC50 nan None None
Homo sapiens Endothelin receptor ET-A Ki nan None None
Homo sapiens Epidermal growth factor receptor erbB1 AC50 400000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Epidermal growth factor receptor erbB1 IC50 nan None None
Homo sapiens Epidermal growth factor receptor erbB1 Ki nan None None
Homo sapiens Equilibrative nucleoside transporter 1 AC50 400000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Estrogen receptor alpha AC50 83000.4 nM 10.1038/s41467-023-40064-9
Homo sapiens Estrogen receptor alpha AC50 400000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Estrogen receptor alpha IC50 nan None None
Homo sapiens Estrogen receptor alpha Ki nan None None
Homo sapiens Estrogen receptor beta IC50 nan None None
Homo sapiens Estrogen receptor beta Ki nan None None
Homo sapiens Gamma-aminobutyric acid receptor subunit alpha-1/alpha-2/beta-2/gamma-2 AC50 400000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Ghrelin receptor AC50 400000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Glucocorticoid receptor AC50 400000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Glucocorticoid receptor IC50 nan None None
Homo sapiens Glucocorticoid receptor Ki nan None None
Homo sapiens HERG AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens HERG IC50 nan None None
Homo sapiens HERG Ki nan None None
Homo sapiens Histamine H1 receptor AC50 400000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Histamine H1 receptor IC50 nan None None
Homo sapiens Histamine H1 receptor Ki nan None None
Homo sapiens Histamine H2 receptor IC50 nan None None
Homo sapiens Histamine H2 receptor Ki nan None None
Homo sapiens Histamine H3 receptor AC50 400000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens HMG-CoA reductase IC50 nan None None
Homo sapiens HMG-CoA reductase Ki nan None None
Homo sapiens Homo sapiens Activity 0.01 % 10.1016/j.ejmech.2009.11.034
Homo sapiens Homo sapiens AUC 336.7 None 10.1128/aac.01522-06
Homo sapiens Homo sapiens AUC 414.4 None 10.1128/aac.01522-06
Homo sapiens Homo sapiens CL 0.5 mL.min-1.kg-1 10.1021/jm901371v
Homo sapiens Homo sapiens CL 1.31 mL.min-1.kg-1 10.1128/aac.01522-06
Homo sapiens Homo sapiens CL 1.5 mL.min-1.kg-1 10.1021/jm900403j
Homo sapiens Homo sapiens CL 1.5 mL.min-1.kg-1 10.1021/jm901371v
Homo sapiens Homo sapiens CL 1.84 mL.min-1.kg-1 10.1128/aac.01522-06
Homo sapiens Homo sapiens CL 4.59 L/hr 10.1128/aac.01522-06
Homo sapiens Homo sapiens CL 6.052 L/hr 10.1128/aac.01522-06
Homo sapiens Homo sapiens CL 76.2 ml/min 10.1128/aac.01522-06
Homo sapiens Homo sapiens CL 100.1 ml/min 10.1128/aac.01522-06
Homo sapiens Homo sapiens CL_renal 0.96 mL.min-1.kg-1 10.1021/jm900403j
Homo sapiens Homo sapiens CL_renal 1.0 mL.min-1.kg-1 10.1021/jm901371v
Homo sapiens Homo sapiens CL_renal 55.2 ml/min 10.1128/aac.01522-06
Homo sapiens Homo sapiens CL_renal 72.8 ml/min 10.1128/aac.01522-06
Homo sapiens Homo sapiens DILI_Concern nan None 10.1016/j.drudis.2016.02.015
Homo sapiens Homo sapiens DILI_severity_class 5.0 None 10.1016/j.drudis.2016.02.015
Homo sapiens Homo sapiens Fa 0.01 None 10.1021/jm901371v
Homo sapiens Homo sapiens F_fraction 0.01 None 10.1021/jm901371v
Homo sapiens Homo sapiens Fg 1.02 None 10.1021/jm901371v
Homo sapiens Homo sapiens Fh 0.98 None 10.1021/jm901371v
Homo sapiens Homo sapiens Fu 0.71 None 10.1128/aac.01522-06
Homo sapiens Homo sapiens Fu 0.72 None 10.1128/aac.01522-06
Homo sapiens Homo sapiens T1/2 0.32 hr 10.1128/aac.01522-06
Homo sapiens Homo sapiens T1/2 1.54 hr 10.1128/aac.01522-06
Homo sapiens Homo sapiens T1/2 1.81 hr 10.1128/aac.01522-06
Homo sapiens Homo sapiens Vc 5.993 l 10.1128/aac.01522-06
Homo sapiens Homo sapiens Vc 7.075 l 10.1128/aac.01522-06
Homo sapiens Homo sapiens Vd 0.109 L.kg-1 10.1128/aac.01522-06
Homo sapiens Homo sapiens Vd 0.112 L.kg-1 10.1128/aac.01522-06
Homo sapiens Homo sapiens Vd 0.206 L.kg-1 10.1128/aac.01522-06
Homo sapiens Homo sapiens Vd 0.241 L.kg-1 10.1128/aac.01522-06
Homo sapiens Homo sapiens Vd 0.25 L.kg-1 10.1128/aac.01522-06
Homo sapiens Homo sapiens Vdss 0.175 L.kg-1 10.1128/aac.01522-06
Homo sapiens Homo sapiens Vdss 0.18 L.kg-1 10.1016/j.ejmech.2009.06.004
Homo sapiens Homo sapiens Vdss 0.18 L.kg-1 10.1021/jm901371v
Homo sapiens Homo sapiens Vdss 0.199 L.kg-1 10.1128/aac.01522-06
Homo sapiens Interleukin-8 receptor A IC50 nan None None
Homo sapiens Interleukin-8 receptor A Ki nan None None
Homo sapiens Interleukin-8 receptor B IC50 nan None None
Homo sapiens Interleukin-8 receptor B Ki nan None None
Homo sapiens Kappa opioid receptor IC50 nan None None
Homo sapiens Kappa opioid receptor Ki nan None None
Homo sapiens Leukocyte common antigen IC50 nan None None
Homo sapiens Leukocyte common antigen Ki nan None None
Homo sapiens Leukocyte elastase IC50 nan None None
Homo sapiens Leukocyte elastase Ki nan None None
Homo sapiens Liver microsomes Activity nan None 10.1021/tx300075j
Homo sapiens Liver microsomes Stability nan % 10.1021/tx300075j
Homo sapiens MAP kinase ERK1 IC50 nan None None
Homo sapiens MAP kinase ERK1 Ki nan None None
Homo sapiens MAP kinase ERK2 IC50 nan None None
Homo sapiens MAP kinase ERK2 Ki nan None None
Homo sapiens MAP kinase p38 alpha IC50 nan None None
Homo sapiens MAP kinase p38 alpha Ki nan None None
Homo sapiens Matrix metalloproteinase-1 IC50 nan None None
Homo sapiens Matrix metalloproteinase-1 Ki nan None None
Homo sapiens Matrix metalloproteinase 9 IC50 nan None None
Homo sapiens Matrix metalloproteinase 9 Ki nan None None
Homo sapiens Melanocortin receptor 3 AC50 400000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Melanocortin receptor 3 IC50 nan None None
Homo sapiens Melanocortin receptor 3 Ki nan None None
Homo sapiens Melanocortin receptor 4 IC50 nan None None
Homo sapiens Melanocortin receptor 4 Ki nan None None
Homo sapiens Melanocortin receptor 5 IC50 nan None None
Homo sapiens Melanocortin receptor 5 Ki nan None None
Homo sapiens Monoamine oxidase A AC50 400000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Monoamine oxidase A IC50 nan None None
Homo sapiens Monoamine oxidase A Ki nan None None
Homo sapiens Motilin receptor AC50 400000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Mu opioid receptor AC50 400000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Mu opioid receptor IC50 nan None None
Homo sapiens Mu opioid receptor Ki nan None None
Homo sapiens Muscarinic acetylcholine receptor M1 AC50 400000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Muscarinic acetylcholine receptor M1 IC50 nan None None
Homo sapiens Muscarinic acetylcholine receptor M1 Ki nan None None
Homo sapiens Muscarinic acetylcholine receptor M2 AC50 400000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Muscarinic acetylcholine receptor M2 IC50 nan None None
Homo sapiens Muscarinic acetylcholine receptor M2 Ki nan None None
Homo sapiens Muscarinic acetylcholine receptor M3 AC50 400000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Muscarinic acetylcholine receptor M3 IC50 nan None None
Homo sapiens Muscarinic acetylcholine receptor M3 Ki nan None None
Homo sapiens Muscarinic acetylcholine receptor M4 IC50 nan None None
Homo sapiens Muscarinic acetylcholine receptor M4 Ki nan None None
Homo sapiens Muscarinic acetylcholine receptor M5 IC50 nan None None
Homo sapiens Muscarinic acetylcholine receptor M5 Ki nan None None
Homo sapiens Neurokinin 1 receptor IC50 nan None None
Homo sapiens Neurokinin 1 receptor Ki nan None None
Homo sapiens Neurokinin 2 receptor IC50 nan None None
Homo sapiens Neurokinin 2 receptor Ki nan None None
Homo sapiens Neuronal acetylcholine receptor protein alpha-4 subunit AC50 400000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Neuropeptide Y receptor type 1 IC50 nan None None
Homo sapiens Neuropeptide Y receptor type 1 Ki nan None None
Homo sapiens Neuropeptide Y receptor type 2 IC50 nan None None
Homo sapiens Neuropeptide Y receptor type 2 Ki nan None None
Homo sapiens Norepinephrine transporter AC50 400000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Norepinephrine transporter IC50 nan None None
Homo sapiens Norepinephrine transporter Ki nan None None
Homo sapiens Peroxisome proliferator-activated receptor gamma AC50 400000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Phosphodiesterase 3A AC50 400000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Phosphodiesterase 4D AC50 400000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Phosphodiesterase 5A IC50 nan None None
Homo sapiens Phosphodiesterase 5A Ki nan None None
Homo sapiens Plasma Fu 0.62 None 10.1021/acsmedchemlett.5b00026
Homo sapiens Plasma Fu 0.62 None 10.1021/jm501506f
Homo sapiens Platelet activating factor receptor IC50 nan None None
Homo sapiens Platelet activating factor receptor Ki nan None None
Homo sapiens Pregnane X receptor AC50 400000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Progesterone receptor AC50 400000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Protein kinase C alpha IC50 nan None None
Homo sapiens Protein kinase C alpha Ki nan None None
Homo sapiens Receptor protein-tyrosine kinase erbB-2 AC50 400000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Receptor protein-tyrosine kinase erbB-2 IC50 nan None None
Homo sapiens Receptor protein-tyrosine kinase erbB-2 Ki nan None None
Homo sapiens Serine/threonine protein phosphatase 2B catalytic subunit, alpha isoform IC50 nan None None
Homo sapiens Serine/threonine protein phosphatase 2B catalytic subunit, alpha isoform Ki nan None None
Homo sapiens Serotonin 1a (5-HT1a) receptor AC50 400000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2a (5-HT2a) receptor AC50 400000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2a (5-HT2a) receptor IC50 nan None None
Homo sapiens Serotonin 2a (5-HT2a) receptor Ki nan None None
Homo sapiens Serotonin 2b (5-HT2b) receptor AC50 400000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2b (5-HT2b) receptor IC50 nan None None
Homo sapiens Serotonin 2b (5-HT2b) receptor Ki nan None None
Homo sapiens Serotonin 2c (5-HT2c) receptor AC50 400000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2c (5-HT2c) receptor IC50 nan None None
Homo sapiens Serotonin 2c (5-HT2c) receptor Ki nan None None
Homo sapiens Serotonin 3a (5-HT3a) receptor AC50 400000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 6 (5-HT6) receptor IC50 nan None None
Homo sapiens Serotonin 6 (5-HT6) receptor Ki nan None None
Homo sapiens Serotonin transporter AC50 400000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin transporter IC50 nan None None
Homo sapiens Serotonin transporter Ki nan None None
Homo sapiens Serum Drug uptake 228.0 mg/L 10.1128/aac.01522-06
Homo sapiens Serum Drug uptake 242.0 mg/L 10.1128/aac.01522-06
Homo sapiens Serum PPB 42.1 % 10.1128/aac.01522-06
Homo sapiens Serum PPB 51.5 % 10.1128/aac.01522-06
Homo sapiens Serum T1/2 0.23 hr 10.1128/aac.01522-06
Homo sapiens Sigma opioid receptor IC50 nan None None
Homo sapiens Sigma opioid receptor Ki nan None None
Homo sapiens Solute carrier family 22 member 8 Inhibition nan % 10.1124/dmd.112.049569
Homo sapiens Thromboxane A2 receptor AC50 400000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Thromboxane-A synthase IC50 nan None None
Homo sapiens Thromboxane-A synthase Ki nan None None
Homo sapiens Type-1 angiotensin II receptor AC50 400000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Tyrosine-protein kinase FYN IC50 nan None None
Homo sapiens Tyrosine-protein kinase FYN Ki nan None None
Homo sapiens Tyrosine-protein kinase LCK IC50 nan None None
Homo sapiens Tyrosine-protein kinase LCK Ki nan None None
Homo sapiens Vascular endothelial growth factor receptor 1 IC50 nan None None
Homo sapiens Vascular endothelial growth factor receptor 1 Ki nan None None
Homo sapiens Vascular endothelial growth factor receptor 2 AC50 400000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Vasoactive intestinal polypeptide receptor 1 IC50 nan None None
Homo sapiens Vasoactive intestinal polypeptide receptor 1 Ki nan None None
Homo sapiens Vasopressin V1a receptor AC50 400000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Vasopressin V1a receptor IC50 nan None None
Homo sapiens Vasopressin V1a receptor Ki nan None None
Janthinobacterium lividum THIN-B proetin Kcat/Km nan None 10.1128/aac.01062-07
Klebsiella aerogenes Klebsiella aerogenes MIC 0.03 ug.mL-1 10.1016/j.ejmech.2016.01.024
Klebsiella aerogenes Klebsiella aerogenes MIC 0.06 ug.mL-1 10.1128/aac.01525-09
Klebsiella aerogenes Klebsiella aerogenes MIC 64.0 ug.mL-1 10.1128/aac.01028-07
Klebsiella aerogenes Klebsiella aerogenes MIC 128.0 ug.mL-1 10.1016/j.ejmech.2018.03.031
Klebsiella aerogenes Klebsiella aerogenes MIC 200.0 nM 10.1021/acs.jmedchem.7b01164
Klebsiella aerogenes Klebsiella aerogenes MIC50 4.0 ug.mL-1 10.1128/aac.01525-09
Klebsiella aerogenes Klebsiella aerogenes MIC50 16.0 ug.mL-1 10.1021/ml200012f
Klebsiella aerogenes Klebsiella aerogenes MIC90 32.0 ug.mL-1 10.1021/jm2014748
Klebsiella aerogenes Klebsiella aerogenes MIC90 32.0 ug.mL-1 10.1021/jm2014875
Klebsiella aerogenes Klebsiella aerogenes MIC90 32.0 ug.mL-1 10.1128/aac.01525-09
Klebsiella aerogenes Klebsiella aerogenes MIC90 64.0 ug.mL-1 10.1021/ml200012f
Klebsiella oxytoca Klebsiella oxytoca MIC 0.06 ug.mL-1 10.1128/aac.01525-09
Klebsiella oxytoca Klebsiella oxytoca MIC 1.0 ug.mL-1 10.1128/aac.01634-07
Klebsiella oxytoca Klebsiella oxytoca MIC 1.0 ug.mL-1 10.1128/aac.01790-09
Klebsiella oxytoca Klebsiella oxytoca MIC 32.0 ug.mL-1 10.1128/aac.01525-09
Klebsiella oxytoca Klebsiella oxytoca MIC 64.0 ug.mL-1 10.1128/aac.01355-08
Klebsiella oxytoca Klebsiella oxytoca MIC 256.0 ug.mL-1 10.1128/aac.01473-08
Klebsiella oxytoca Klebsiella oxytoca MIC50 16.0 ug.mL-1 10.1128/aac.01525-09
Klebsiella oxytoca Klebsiella oxytoca MIC90 32.0 ug.mL-1 10.1128/aac.01525-09
Klebsiella pneumoniae Beta-lactamase NDM-1 Km nan None 10.1128/aac.00774-09
Klebsiella pneumoniae Beta-lactamase SHV-1 Kcat 0.1 /s 10.1128/aac.01525-07
Klebsiella pneumoniae Beta-lactamase SHV-1 Kcat/Km nan None 10.1128/aac.01525-07
Klebsiella pneumoniae Beta-lactamase SHV-1 Km nan None 10.1128/aac.01525-07
Klebsiella pneumoniae Beta-lactamase SHV-55 Kcat 0.1 /s 10.1128/aac.01525-07
Klebsiella pneumoniae Beta-lactamase SHV-55 Kcat/Km nan None 10.1128/aac.01525-07
Klebsiella pneumoniae Beta-lactamase SHV-55 Km 5000.0 nM 10.1128/aac.01525-07
Klebsiella pneumoniae Carbepenem-hydrolyzing beta-lactamase KPC Kcat 20.0 /s 10.1128/aac.00491-07
Klebsiella pneumoniae Carbepenem-hydrolyzing beta-lactamase KPC Kcat/Km 70.0 /mM/s 10.1128/aac.00491-07
Klebsiella pneumoniae Carbepenem-hydrolyzing beta-lactamase KPC Km 310000.0 nM 10.1128/aac.00491-07
Klebsiella pneumoniae Class C beta-lactamase CMY-36 IC50 6.0 nM 10.1128/aac.01284-08
Klebsiella pneumoniae Extended spectrum beta-lactamase CTX-M-71 Kcat 0.84 /s 10.1128/aac.00461-09
Klebsiella pneumoniae Extended spectrum beta-lactamase CTX-M-71 Km 10000.0 nM 10.1128/aac.00461-09
Klebsiella pneumoniae Extended spectrum beta-lactamase CTX-M-71 Ratio 0.084 None 10.1128/aac.00461-09
Klebsiella pneumoniae Klebsiella pneumoniae Activity 0.0 % 10.1128/aac.01509-06
Klebsiella pneumoniae Klebsiella pneumoniae Activity 0.0 % 10.1128/aac.01821-09
Klebsiella pneumoniae Klebsiella pneumoniae Activity 6.7 % 10.1128/aac.00762-09
Klebsiella pneumoniae Klebsiella pneumoniae Activity 14.3 % 10.1128/aac.01821-09
Klebsiella pneumoniae Klebsiella pneumoniae Activity 16.7 % 10.1128/aac.00762-09
Klebsiella pneumoniae Klebsiella pneumoniae Activity 17.5 % 10.1128/aac.00762-09
Klebsiella pneumoniae Klebsiella pneumoniae Activity nan None 10.1016/j.bmcl.2018.01.006
Klebsiella pneumoniae Klebsiella pneumoniae Inhibition nan % 10.1128/aac.01452-08
Klebsiella pneumoniae Klebsiella pneumoniae MBC 0.5 ug ml-1 10.1128/aac.01452-08
Klebsiella pneumoniae Klebsiella pneumoniae MBC 1.0 ug ml-1 10.1128/aac.01452-08
Klebsiella pneumoniae Klebsiella pneumoniae MBC 64.0 ug ml-1 10.1128/aac.01452-08
Klebsiella pneumoniae Klebsiella pneumoniae MIC 0.015 ug.mL-1 10.1128/aac.01381-07
Klebsiella pneumoniae Klebsiella pneumoniae MIC 0.03 ug.mL-1 10.1016/j.ejmech.2016.01.024
Klebsiella pneumoniae Klebsiella pneumoniae MIC 0.03 ug.mL-1 10.1021/jm00128a014
Klebsiella pneumoniae Klebsiella pneumoniae MIC 0.06 ug.mL-1 10.1021/jm00128a014
Klebsiella pneumoniae Klebsiella pneumoniae MIC 0.06 ug.mL-1 10.1128/aac.01312-09
Klebsiella pneumoniae Klebsiella pneumoniae MIC 0.064 ug.mL-1 10.1128/aac.00543-08
Klebsiella pneumoniae Klebsiella pneumoniae MIC 0.064 ug.mL-1 10.1128/aac.01301-09
Klebsiella pneumoniae Klebsiella pneumoniae MIC 0.064 ug.mL-1 10.1128/aac.01473-08
Klebsiella pneumoniae Klebsiella pneumoniae MIC 0.12 ug.mL-1 10.1021/jm00128a014
Klebsiella pneumoniae Klebsiella pneumoniae MIC 0.12 ug.mL-1 10.1128/aac.00690-09
Klebsiella pneumoniae Klebsiella pneumoniae MIC 0.25 ug.mL-1 10.1128/aac.01301-09
Klebsiella pneumoniae Klebsiella pneumoniae MIC 0.25 ug.mL-1 10.1128/aac.01452-08
Klebsiella pneumoniae Klebsiella pneumoniae MIC 0.5 ug.mL-1 10.1016/j.ejmech.2018.03.031
Klebsiella pneumoniae Klebsiella pneumoniae MIC 0.5 ug.mL-1 10.1128/aac.01452-08
Klebsiella pneumoniae Klebsiella pneumoniae MIC 0.5 ug.mL-1 10.1128/aac.01672-07
Klebsiella pneumoniae Klebsiella pneumoniae MIC 1.0 ug.mL-1 10.1128/aac.01634-07
Klebsiella pneumoniae Klebsiella pneumoniae MIC 2.0 ug.mL-1 10.1128/aac.00458-09
Klebsiella pneumoniae Klebsiella pneumoniae MIC 4.0 ug.mL-1 10.1128/aac.00167-07
Klebsiella pneumoniae Klebsiella pneumoniae MIC 6.0 ug.mL-1 10.1128/aac.01473-08
Klebsiella pneumoniae Klebsiella pneumoniae MIC 8.0 ug.mL-1 10.1128/aac.00017-09
Klebsiella pneumoniae Klebsiella pneumoniae MIC 16.0 ug.mL-1 10.1016/j.bmcl.2021.127878
Klebsiella pneumoniae Klebsiella pneumoniae MIC 16.0 ug.mL-1 10.1016/j.ejmech.2016.01.024
Klebsiella pneumoniae Klebsiella pneumoniae MIC 16.0 ug.mL-1 10.1016/j.ejmech.2019.02.024
Klebsiella pneumoniae Klebsiella pneumoniae MIC 16.0 ug.mL-1 10.1128/aac.00017-09
Klebsiella pneumoniae Klebsiella pneumoniae MIC 16.0 ug.mL-1 10.1128/aac.01634-07
Klebsiella pneumoniae Klebsiella pneumoniae MIC 24.0 ug.mL-1 10.1128/aac.01440-07
Klebsiella pneumoniae Klebsiella pneumoniae MIC 32.0 ug.mL-1 10.1016/j.ejmech.2016.01.024
Klebsiella pneumoniae Klebsiella pneumoniae MIC 32.0 ug.mL-1 10.1128/aac.00299-07
Klebsiella pneumoniae Klebsiella pneumoniae MIC 32.0 ug.mL-1 10.1128/aac.00690-09
Klebsiella pneumoniae Klebsiella pneumoniae MIC 32.0 ug.mL-1 10.1128/aac.01301-09
Klebsiella pneumoniae Klebsiella pneumoniae MIC 32.0 ug.mL-1 10.1128/aac.01440-07
Klebsiella pneumoniae Klebsiella pneumoniae MIC 32.0 ug.mL-1 10.1128/aac.01473-08
Klebsiella pneumoniae Klebsiella pneumoniae MIC 32.0 ug.mL-1 10.1128/aac.01525-09
Klebsiella pneumoniae Klebsiella pneumoniae MIC 32.0 ug.mL-1 10.1128/aac.01818-09
Klebsiella pneumoniae Klebsiella pneumoniae MIC 48.0 ug.mL-1 10.1128/aac.01440-07
Klebsiella pneumoniae Klebsiella pneumoniae MIC 64.0 ug.mL-1 10.1016/j.bmc.2022.116722
Klebsiella pneumoniae Klebsiella pneumoniae MIC 64.0 ug.mL-1 10.1016/j.bmcl.2018.01.006
Klebsiella pneumoniae Klebsiella pneumoniae MIC 64.0 ug.mL-1 10.1016/j.bmcl.2021.127878
Klebsiella pneumoniae Klebsiella pneumoniae MIC 64.0 ug.mL-1 10.1016/j.ejmech.2018.03.058
Klebsiella pneumoniae Klebsiella pneumoniae MIC 64.0 ug.mL-1 10.1021/acs.jmedchem.6b01261
Klebsiella pneumoniae Klebsiella pneumoniae MIC 64.0 ug.mL-1 10.1021/jm400560z
Klebsiella pneumoniae Klebsiella pneumoniae MIC 64.0 ug.mL-1 10.1021/jm500219c
Klebsiella pneumoniae Klebsiella pneumoniae MIC 64.0 ug.mL-1 10.1021/ml200012f
Klebsiella pneumoniae Klebsiella pneumoniae MIC 64.0 ug.mL-1 10.1128/aac.00011-10
Klebsiella pneumoniae Klebsiella pneumoniae MIC 64.0 ug.mL-1 10.1128/aac.00158-08
Klebsiella pneumoniae Klebsiella pneumoniae MIC 64.0 ug.mL-1 10.1128/aac.00299-07
Klebsiella pneumoniae Klebsiella pneumoniae MIC 64.0 ug.mL-1 10.1128/aac.00690-09
Klebsiella pneumoniae Klebsiella pneumoniae MIC 64.0 ug.mL-1 10.1128/aac.00736-08
Klebsiella pneumoniae Klebsiella pneumoniae MIC 64.0 ug.mL-1 10.1128/aac.01355-08
Klebsiella pneumoniae Klebsiella pneumoniae MIC 64.0 ug.mL-1 10.1128/aac.01440-07
Klebsiella pneumoniae Klebsiella pneumoniae MIC 64.0 ug.mL-1 10.1128/aac.01452-08
Klebsiella pneumoniae Klebsiella pneumoniae MIC 64.0 ug.mL-1 10.1128/aac.01818-09
Klebsiella pneumoniae Klebsiella pneumoniae MIC 96.0 ug.mL-1 10.1128/aac.01301-09
Klebsiella pneumoniae Klebsiella pneumoniae MIC 96.0 ug.mL-1 10.1128/aac.01451-07
Klebsiella pneumoniae Klebsiella pneumoniae MIC 128.0 ug.mL-1 10.1016/j.ejmech.2018.03.031
Klebsiella pneumoniae Klebsiella pneumoniae MIC 128.0 ug.mL-1 10.1128/aac.00461-09
Klebsiella pneumoniae Klebsiella pneumoniae MIC 128.0 ug.mL-1 10.1128/aac.00909-06
Klebsiella pneumoniae Klebsiella pneumoniae MIC 128.0 ug.mL-1 10.1128/aac.01440-07
Klebsiella pneumoniae Klebsiella pneumoniae MIC 256.0 ug.mL-1 10.1016/j.ejmech.2016.01.024
Klebsiella pneumoniae Klebsiella pneumoniae MIC 256.0 ug.mL-1 10.1016/j.ejmech.2019.02.024
Klebsiella pneumoniae Klebsiella pneumoniae MIC 256.0 ug.mL-1 10.1128/aac.00543-08
Klebsiella pneumoniae Klebsiella pneumoniae MIC 256.0 ug.mL-1 10.1128/aac.00736-08
Klebsiella pneumoniae Klebsiella pneumoniae MIC 256.0 ug.mL-1 10.1128/aac.00774-09
Klebsiella pneumoniae Klebsiella pneumoniae MIC 256.0 ug.mL-1 10.1128/aac.01053-06
Klebsiella pneumoniae Klebsiella pneumoniae MIC 256.0 ug.mL-1 10.1128/aac.01180-07
Klebsiella pneumoniae Klebsiella pneumoniae MIC 256.0 ug.mL-1 10.1128/aac.01301-09
Klebsiella pneumoniae Klebsiella pneumoniae MIC 256.0 ug.mL-1 10.1128/aac.01440-07
Klebsiella pneumoniae Klebsiella pneumoniae MIC 256.0 ug.mL-1 10.1128/aac.01451-07
Klebsiella pneumoniae Klebsiella pneumoniae MIC 256.0 ug.mL-1 10.1128/aac.01539-07
Klebsiella pneumoniae Klebsiella pneumoniae MIC 512.0 ug.mL-1 10.1128/aac.01312-09
Klebsiella pneumoniae Klebsiella pneumoniae MIC 512.0 ug.mL-1 10.1128/aac.01672-07
Klebsiella pneumoniae Klebsiella pneumoniae MIC50 0.06 ug.mL-1 10.1128/aac.00762-09
Klebsiella pneumoniae Klebsiella pneumoniae MIC50 16.0 ug.mL-1 10.1128/aac.01821-09
Klebsiella pneumoniae Klebsiella pneumoniae MIC50 32.0 ug.mL-1 10.1021/acs.jmedchem.0c00255
Klebsiella pneumoniae Klebsiella pneumoniae MIC50 32.0 ug.mL-1 10.1021/jm400560z
Klebsiella pneumoniae Klebsiella pneumoniae MIC50 64.0 ug.mL-1 10.1021/jm400560z
Klebsiella pneumoniae Klebsiella pneumoniae MIC50 64.0 ug.mL-1 10.1021/ml200012f
Klebsiella pneumoniae Klebsiella pneumoniae MIC50 256.0 ug.mL-1 10.1128/aac.01509-06
Klebsiella pneumoniae Klebsiella pneumoniae MIC50 512.0 ug.mL-1 10.1128/aac.01821-09
Klebsiella pneumoniae Klebsiella pneumoniae MIC90 32.0 ug.mL-1 10.1021/acs.jmedchem.0c00255
Klebsiella pneumoniae Klebsiella pneumoniae MIC90 64.0 ug.mL-1 10.1021/jm2014748
Klebsiella pneumoniae Klebsiella pneumoniae MIC90 64.0 ug.mL-1 10.1021/jm2014875
Klebsiella pneumoniae Klebsiella pneumoniae MIC90 64.0 ug.mL-1 10.1021/jm400560z
Klebsiella pneumoniae Klebsiella pneumoniae MIC90 64.0 ug.mL-1 10.1021/ml200012f
Klebsiella pneumoniae Klebsiella pneumoniae MIC90 64.0 ug.mL-1 10.1128/aac.00762-09
Klebsiella pneumoniae Klebsiella pneumoniae MIC90 128.0 ug.mL-1 10.1128/aac.01821-09
Klebsiella pneumoniae Klebsiella pneumoniae MIC90 256.0 ug.mL-1 10.1128/aac.01509-06
Klebsiella pneumoniae Klebsiella pneumoniae MIC90 512.0 ug.mL-1 10.1021/jm501506f
Klebsiella pneumoniae Klebsiella pneumoniae MIC90 512.0 ug.mL-1 10.1128/aac.01821-09
Klebsiella pneumoniae Metallo-beta-lactamase VIM-2 Kcat 0.5 /s 10.1128/aac.00774-09
Klebsiella pneumoniae Metallo-beta-lactamase VIM-2 Kcat/Km nan None 10.1128/aac.00774-09
Klebsiella pneumoniae Metallo-beta-lactamase VIM-2 Km nan None 10.1128/aac.00774-09
Klebsiella sp. Klebsiella sp. Activity 10.4 % 10.1128/aac.01114-07
Klebsiella sp. Klebsiella sp. Activity 87.5 % 10.1128/aac.01114-07
Klebsiella sp. Klebsiella sp. MIC50 16.0 ug.mL-1 10.1128/aac.01114-07
Klebsiella sp. Klebsiella sp. MIC90 16.0 ug.mL-1 10.1128/aac.01114-07
Listeria monocytogenes Listeria monocytogenes MIC 1.0 ug.mL-1 10.1128/aac.01790-09
Micrococcus luteus Micrococcus luteus MIC 64.0 ug.mL-1 10.1128/aac.01790-09
Morganella morganii Morganella morganii MIC 0.015 ug.mL-1 10.1021/jm00128a014
Morganella morganii Morganella morganii MIC 0.03 ug.mL-1 10.1021/jm00128a014
Morganella morganii Morganella morganii MIC 0.125 ug.mL-1 10.1016/j.ejmech.2016.01.024
Morganella morganii Morganella morganii MIC 1.0 ug.mL-1 10.1128/aac.01634-07
Morganella morganii Morganella morganii MIC 4.0 ug.mL-1 10.1128/aac.01634-07
Mus musculus Mus musculus AUC 5000.0 ng.hr.mL-1 10.1016/j.bmcl.2018.01.006
Mus musculus Mus musculus Challenge dose 3400.0 None 10.1016/S0960-894X(01)80574-6
Mus musculus Mus musculus Challenge dose 630000.0 None 10.1016/S0960-894X(01)80574-6
Mus musculus Mus musculus CL 16.0 mL.min-1.kg-1 10.1016/j.bmcl.2018.01.006
Mus musculus Mus musculus Drugexcretion nan None 10.1016/j.bmcl.2018.01.006
Mus musculus Mus musculus ED50 100.0 mg.kg-1 10.1016/S0960-894X(01)80574-6
Mus musculus Mus musculus ED50 122.35 mg.kg-1 10.1016/S0960-894X(01)80574-6
Mus musculus Mus musculus MIC 1.56 None 10.1016/S0960-894X(01)80574-6
Mus musculus Mus musculus MIC 12.5 ug.mL-1 10.1016/S0960-894X(01)80574-6
Mus musculus Mus musculus MTD 400.0 mg Kg-1 10.1128/aac.00268-09
Mus musculus Mus musculus T1/2 0.2 hr 10.1016/j.bmcl.2018.01.006
Mus musculus Mus musculus Vd 0.2 L.kg-1 10.1016/j.bmcl.2018.01.006
Mus musculus Nitric oxide synthase, inducible IC50 nan None None
Mus musculus Nitric oxide synthase, inducible Ki nan None None
Mus musculus Solute carrier family 22 member 6 Inhibition nan % 10.1124/dmd.112.049569
Mus musculus Solute carrier family 22 member 8 Inhibition nan % 10.1124/dmd.112.049569
Mus musculus Solute carrier family 22 member 8 PPB nan % 10.1124/dmd.112.049569
Oryctolagus cuniculus Angiotensin-converting enzyme IC50 nan None None
Oryctolagus cuniculus Angiotensin-converting enzyme Ki nan None None
Oryctolagus cuniculus Arachidonate 15-lipoxygenase IC50 nan None None
Oryctolagus cuniculus Arachidonate 15-lipoxygenase Ki nan None None
Parabacteroides distasonis Parabacteroides distasonis MIC 64.0 ug.mL-1 10.1016/S0960-894X(01)80932-X
Pectobacterium atrosepticum Pectobacterium atrosepticum MIC 16.0 ug.mL-1 10.1128/aac.01062-07
Prevotella melaninogenica Prevotella melaninogenica MIC 4.0 ug.mL-1 10.1016/S0960-894X(01)80932-X
Proteus mirabilis Proteus mirabilis Activity 0.0 % 10.1128/aac.01509-06
Proteus mirabilis Proteus mirabilis MIC 0.03 ug.mL-1 10.1016/j.ejmech.2016.01.024
Proteus mirabilis Proteus mirabilis MIC 16.0 ug.mL-1 10.1128/aac.01399-07
Proteus mirabilis Proteus mirabilis MIC 50.0 nM 10.1021/acs.jmedchem.7b01164
Proteus mirabilis Proteus mirabilis MIC50 0.25 ug.mL-1 10.1128/aac.01509-06
Proteus mirabilis Proteus mirabilis MIC90 1.0 ug.mL-1 10.1128/aac.01509-06
Proteus sp. Proteus sp. IZ 24.0 mm 10.1016/j.bmc.2016.01.041
Proteus vulgaris Proteus vulgaris MIC 0.03 ug.mL-1 10.1016/j.ejmech.2016.01.024
Providencia rettgeri Providencia rettgeri MIC 0.03 ug.mL-1 10.1016/j.ejmech.2016.01.024
Providencia rettgeri Providencia rettgeri MIC 2.0 ug.mL-1 10.1128/aac.01525-09
Providencia rettgeri Providencia rettgeri MIC 512.0 ug.mL-1 10.1128/aac.01312-09
Providencia stuartii Providencia stuartii MIC 0.015 ug.mL-1 10.1021/jm00128a014
Providencia stuartii Providencia stuartii MIC 2.0 ug.mL-1 10.1128/aac.00017-09
Pseudomonas aeruginosa Beta-lactamase Kcat 0.1 /s 10.1128/aac.00859-09
Pseudomonas aeruginosa Beta-lactamase Kcat nan None 10.1128/aac.01410-08
Pseudomonas aeruginosa Beta-lactamase Kcat/Km 280.0 /mM/s 10.1128/aac.00859-09
Pseudomonas aeruginosa Beta-lactamase Kcat/Km nan None 10.1128/aac.01410-08
Pseudomonas aeruginosa Beta-lactamase Km 360.0 nM 10.1128/aac.00859-09
Pseudomonas aeruginosa Beta-lactamase Km nan None 10.1128/aac.01410-08
Pseudomonas aeruginosa Beta-lactamase bla(BEL1) Kcat 10.0 /s 10.1128/aac.00859-09
Pseudomonas aeruginosa Beta-lactamase bla(BEL1) Kcat/Km 100.0 /mM/s 10.1128/aac.00859-09
Pseudomonas aeruginosa Beta-lactamase bla(BEL1) Km 100000.0 nM 10.1128/aac.00859-09
Pseudomonas aeruginosa Beta-lactamase GES-13 Kcat 35.6 /s 10.1128/aac.01561-09
Pseudomonas aeruginosa Beta-lactamase GES-13 Kcat/Km 0.09 /uM/s 10.1128/aac.01561-09
Pseudomonas aeruginosa Beta-lactamase GES-13 Km 405000.0 nM 10.1128/aac.01561-09
Pseudomonas aeruginosa Beta-lactamase VIM-2 Activity nan None 10.1128/aac.00175-08
Pseudomonas aeruginosa Beta-lactamase VIM-2 Kcat 0.01 /s 10.1128/aac.00166-08
Pseudomonas aeruginosa Beta-lactamase VIM-2 Kcat nan None 10.1128/aac.00175-08
Pseudomonas aeruginosa Beta-lactamase VIM-2 Kcat/Km 1.0 10'2 uM/s 10.1128/aac.00166-08
Pseudomonas aeruginosa Beta-lactamase VIM-2 Kcat/Km nan None 10.1128/aac.00175-08
Pseudomonas aeruginosa Beta-lactamase VIM-2 Km 1000000.0 nM 10.1128/aac.00166-08
Pseudomonas aeruginosa Beta-lactamase VIM-2 Km nan None 10.1128/aac.00175-08
Pseudomonas aeruginosa Metallo-beta-lactamase VIM-11 Kcat/Km nan None 10.1128/aac.01025-07
Pseudomonas aeruginosa Metallo-beta-lactamase VIM-2 Kcat/Km nan None 10.1128/aac.01025-07
Pseudomonas aeruginosa Metallo-b-lactamase Kcat nan None 10.1128/aac.00166-08
Pseudomonas aeruginosa Metallo-b-lactamase Kcat/Km nan None 10.1128/aac.00166-08
Pseudomonas aeruginosa Metallo-b-lactamase Km 2700000.0 nM 10.1128/aac.00166-08
Pseudomonas aeruginosa Penicillin-binding protein 1B IC50 2.0 ug.mL-1 10.1128/aac.00029-07
Pseudomonas aeruginosa Penicillin-binding protein 2 IC50 16.0 ug.mL-1 10.1128/aac.00029-07
Pseudomonas aeruginosa Penicillin-binding protein 3 IC50 0.03 ug.mL-1 10.1128/aac.00029-07
Pseudomonas aeruginosa Pseudomonas aeruginosa Activity 6.7 % 10.1128/aac.00503-07
Pseudomonas aeruginosa Pseudomonas aeruginosa Activity 18.9 % 10.1128/aac.00851-06
Pseudomonas aeruginosa Pseudomonas aeruginosa Activity 19.0 % 10.1128/aac.00810-07
Pseudomonas aeruginosa Pseudomonas aeruginosa Activity 20.0 % 10.1128/aac.00268-09
Pseudomonas aeruginosa Pseudomonas aeruginosa Activity 24.0 % 10.1128/aac.00679-07
Pseudomonas aeruginosa Pseudomonas aeruginosa Activity 33.0 % 10.1128/aac.01483-06
Pseudomonas aeruginosa Pseudomonas aeruginosa Activity 44.1 % 10.1128/aac.00453-09
Pseudomonas aeruginosa Pseudomonas aeruginosa Activity 53.0 % 10.1128/aac.00810-07
Pseudomonas aeruginosa Pseudomonas aeruginosa Activity 53.0 % 10.1128/aac.00834-09
Pseudomonas aeruginosa Pseudomonas aeruginosa Activity 58.1 % 10.1128/aac.00851-06
Pseudomonas aeruginosa Pseudomonas aeruginosa Activity 75.0 % 10.1128/aac.00707-08
Pseudomonas aeruginosa Pseudomonas aeruginosa Activity 75.8 % 10.1128/aac.00503-07
Pseudomonas aeruginosa Pseudomonas aeruginosa Activity 79.0 % 10.1128/aac.00851-06
Pseudomonas aeruginosa Pseudomonas aeruginosa Activity 256.0 ug ml-1 10.1128/aac.01043-06
Pseudomonas aeruginosa Pseudomonas aeruginosa Activity nan None 10.1016/j.bmcl.2005.02.029
Pseudomonas aeruginosa Pseudomonas aeruginosa Activity nan None 10.1128/aac.00428-08
Pseudomonas aeruginosa Pseudomonas aeruginosa Activity nan None 10.1128/aac.01278-06
Pseudomonas aeruginosa Pseudomonas aeruginosa BBC 8.0 ug ml-1 10.1128/aac.00248-09
Pseudomonas aeruginosa Pseudomonas aeruginosa BBC 64.0 ug ml-1 10.1128/aac.00248-09
Pseudomonas aeruginosa Pseudomonas aeruginosa BBC 256.0 ug ml-1 10.1128/aac.00248-09
Pseudomonas aeruginosa Pseudomonas aeruginosa FC 32.0 None 10.1128/aac.01024-08
Pseudomonas aeruginosa Pseudomonas aeruginosa Inhibition 30.0 % 10.1021/jm900615h
Pseudomonas aeruginosa Pseudomonas aeruginosa Inhibition 95.0 % 10.1021/jm900615h
Pseudomonas aeruginosa Pseudomonas aeruginosa Inhibition nan % 10.1128/aac.01452-08
Pseudomonas aeruginosa Pseudomonas aeruginosa IZ 10.7 mm 10.1128/aac.01617-08
Pseudomonas aeruginosa Pseudomonas aeruginosa IZ 11.8 mm 10.1128/aac.01617-08
Pseudomonas aeruginosa Pseudomonas aeruginosa IZ 11.9 mm 10.1128/aac.01617-08
Pseudomonas aeruginosa Pseudomonas aeruginosa IZ 12.5 mm 10.1128/aac.01617-08
Pseudomonas aeruginosa Pseudomonas aeruginosa IZ 14.0 mm 10.1128/aac.01617-08
Pseudomonas aeruginosa Pseudomonas aeruginosa IZ 15.1 mm 10.1128/aac.01617-08
Pseudomonas aeruginosa Pseudomonas aeruginosa log10cfu 1.25 None 10.1128/aac.00268-09
Pseudomonas aeruginosa Pseudomonas aeruginosa MBC 4.0 ug ml-1 10.1128/aac.01452-08
Pseudomonas aeruginosa Pseudomonas aeruginosa MBC 8.0 ug ml-1 10.1128/aac.01452-08
Pseudomonas aeruginosa Pseudomonas aeruginosa MBC 32.0 ug ml-1 10.1128/aac.01452-08
Pseudomonas aeruginosa Pseudomonas aeruginosa MBC 64.0 ug ml-1 10.1128/aac.01452-08
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 0.008 ug.mL-1 10.1128/aac.01522-06
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 0.1 ug.mL-1 10.1128/aac.00511-08
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 0.12 ug.mL-1 10.1128/aac.00816-09
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 0.12 ug.mL-1 10.1128/aac.01024-08
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 0.13 ug.mL-1 10.1128/aac.01495-09
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 0.19 ug.mL-1 10.1128/aac.01451-07
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 0.25 ug.mL-1 10.1016/j.bmcl.2018.01.006
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 0.25 ug.mL-1 10.1021/jm501506f
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 0.25 ug.mL-1 10.1128/aac.00707-08
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 0.25 ug.mL-1 10.1128/aac.01024-08
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 0.25 ug.mL-1 10.1128/aac.01495-09
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 0.25 ug.mL-1 10.1128/aac.01525-09
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 0.25 ug.mL-1 10.1128/aac.01617-08
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 0.5 ug.mL-1 10.1016/j.ejmech.2016.01.024
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 0.5 ug.mL-1 10.1128/aac.00248-09
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 0.5 ug.mL-1 10.1128/aac.00503-07
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 0.5 ug.mL-1 10.1128/aac.00816-09
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 0.5 ug.mL-1 10.1128/aac.01024-08
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 0.5 ug.mL-1 10.1128/aac.01264-08
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 0.75 ug.mL-1 10.1128/aac.01264-08
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 1.0 ug.mL-1 10.1128/aac.00248-09
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 1.0 ug.mL-1 10.1128/aac.00428-08
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 1.0 ug.mL-1 10.1128/aac.00465-08
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 1.0 ug.mL-1 10.1128/aac.00816-09
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 1.0 ug.mL-1 10.1128/aac.01107-07
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 1.0 ug.mL-1 10.1128/aac.01264-08
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 1.0 ug.mL-1 10.1128/aac.01617-08
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 1.5 ug.mL-1 10.1128/aac.00174-07
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 1.5 ug.mL-1 10.1128/aac.00428-08
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 1.5 ug.mL-1 10.1128/aac.00465-08
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 1.5 ug.mL-1 10.1128/aac.00900-09
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 1.5 ug.mL-1 10.1128/aac.01264-08
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 1.56 ug.mL-1 10.1128/aac.00511-08
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 2.0 ug.mL-1 10.1016/j.ejmech.2016.01.024
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 2.0 ug.mL-1 10.1128/aac.00385-10
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 2.0 ug.mL-1 10.1128/aac.00574-09
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 2.0 ug.mL-1 10.1128/aac.00810-07
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 2.0 ug.mL-1 10.1128/aac.00816-09
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 2.0 ug.mL-1 10.1128/aac.00822-09
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 2.0 ug.mL-1 10.1128/aac.01024-08
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 2.0 ug.mL-1 10.1128/aac.01264-08
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 2.0 ug.mL-1 10.1128/aac.01360-08
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 2.0 ug.mL-1 10.1128/aac.01452-08
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 2.0 ug.mL-1 10.1128/aac.01495-09
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 3.0 ug.mL-1 10.1128/aac.00385-10
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 3.12 ug.mL-1 10.1128/aac.00511-08
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 4.0 ug.mL-1 10.1016/j.bmcl.2018.01.006
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 4.0 ug.mL-1 10.1016/j.bmcl.2021.127878
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 4.0 ug.mL-1 10.1016/j.ejmech.2010.10.007
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 4.0 ug.mL-1 10.1016/j.ejmech.2016.01.024
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 4.0 ug.mL-1 10.1021/acs.jmedchem.6b01261
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 4.0 ug.mL-1 10.1021/acsmedchemlett.5b00026
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 4.0 ug.mL-1 10.1021/jm400560z
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 4.0 ug.mL-1 10.1021/jm500219c
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 4.0 ug.mL-1 10.1021/jm501506f
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 4.0 ug.mL-1 10.1128/aac.00029-07
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 4.0 ug.mL-1 10.1128/aac.00080-10
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 4.0 ug.mL-1 10.1128/aac.00110-10
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 4.0 ug.mL-1 10.1128/aac.00248-09
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 4.0 ug.mL-1 10.1128/aac.00268-09
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 4.0 ug.mL-1 10.1128/aac.00341-08
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 4.0 ug.mL-1 10.1128/aac.00385-10
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 4.0 ug.mL-1 10.1128/aac.00465-08
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 4.0 ug.mL-1 10.1128/aac.00503-07
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 4.0 ug.mL-1 10.1128/aac.00574-09
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 4.0 ug.mL-1 10.1128/aac.00707-08
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 4.0 ug.mL-1 10.1128/aac.00816-09
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 4.0 ug.mL-1 10.1128/aac.01024-08
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 4.0 ug.mL-1 10.1128/aac.01104-09
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 4.0 ug.mL-1 10.1128/aac.01107-07
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 4.0 ug.mL-1 10.1128/aac.01452-08
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 4.0 ug.mL-1 10.1128/aac.01495-09
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 4.0 ug.mL-1 10.1128/aac.01525-09
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 4.0 ug.mL-1 10.1128/aac.01529-07
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 4.0 ug.mL-1 10.1128/aac.01573-08
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 4.0 ug.mL-1 10.1128/aac.01617-08
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 6.0 ug.mL-1 10.1128/aac.00385-10
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 6.0 ug.mL-1 10.1128/aac.00707-08
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 6.0 ug.mL-1 10.1128/aac.01617-08
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 8.0 ug.mL-1 10.1021/ml200012f
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 8.0 ug.mL-1 10.1128/aac.00080-10
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 8.0 ug.mL-1 10.1128/aac.00110-10
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 8.0 ug.mL-1 10.1128/aac.00248-09
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 8.0 ug.mL-1 10.1128/aac.00385-10
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 8.0 ug.mL-1 10.1128/aac.00503-07
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 8.0 ug.mL-1 10.1128/aac.00574-09
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 8.0 ug.mL-1 10.1128/aac.00679-07
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 8.0 ug.mL-1 10.1128/aac.00707-08
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 8.0 ug.mL-1 10.1128/aac.00822-09
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 8.0 ug.mL-1 10.1128/aac.01104-09
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 8.0 ug.mL-1 10.1128/aac.01345-06
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 8.0 ug.mL-1 10.1128/aac.01452-08
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 8.0 ug.mL-1 10.1128/aac.01483-06
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 8.0 ug.mL-1 10.1128/aac.01525-09
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 8.0 ug.mL-1 10.1128/aac.01790-09
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 12.0 ug.mL-1 10.1128/aac.00385-10
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 12.0 ug.mL-1 10.1128/aac.01573-08
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 12.5 ug.mL-1 10.1128/aac.00511-08
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 16.0 ug.mL-1 10.1016/j.bmcl.2021.127878
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 16.0 ug.mL-1 10.1128/aac.00080-10
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 16.0 ug.mL-1 10.1128/aac.00110-10
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 16.0 ug.mL-1 10.1128/aac.00175-08
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 16.0 ug.mL-1 10.1128/aac.00248-09
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 16.0 ug.mL-1 10.1128/aac.00341-08
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 16.0 ug.mL-1 10.1128/aac.00503-07
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 16.0 ug.mL-1 10.1128/aac.00574-09
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 16.0 ug.mL-1 10.1128/aac.00679-07
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 16.0 ug.mL-1 10.1128/aac.00707-08
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 16.0 ug.mL-1 10.1128/aac.00816-09
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 16.0 ug.mL-1 10.1128/aac.00859-09
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 16.0 ug.mL-1 10.1128/aac.01011-08
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 16.0 ug.mL-1 10.1128/aac.01525-09
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 16.0 ug.mL-1 10.1128/aac.01646-09
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 24.0 ug.mL-1 10.1128/aac.00385-10
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 24.0 ug.mL-1 10.1128/aac.00465-08
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 24.0 ug.mL-1 10.1128/aac.01617-08
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 32.0 ug.mL-1 10.1016/j.bmcl.2018.01.006
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 32.0 ug.mL-1 10.1016/j.ejmech.2018.03.058
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 32.0 ug.mL-1 10.1128/aac.00080-10
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 32.0 ug.mL-1 10.1128/aac.00110-10
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 32.0 ug.mL-1 10.1128/aac.00175-08
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 32.0 ug.mL-1 10.1128/aac.00248-09
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 32.0 ug.mL-1 10.1128/aac.00385-10
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 32.0 ug.mL-1 10.1128/aac.00574-09
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 32.0 ug.mL-1 10.1128/aac.00679-07
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 32.0 ug.mL-1 10.1128/aac.00816-09
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 32.0 ug.mL-1 10.1128/aac.01104-09
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 32.0 ug.mL-1 10.1128/aac.01525-09
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 32.0 ug.mL-1 10.1128/aac.01646-09
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 48.0 ug.mL-1 10.1128/aac.00341-08
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 64.0 ug.mL-1 10.1016/j.bmcl.2018.01.006
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 64.0 ug.mL-1 10.1016/j.ejmech.2018.03.058
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 64.0 ug.mL-1 10.1021/jm400560z
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 64.0 ug.mL-1 10.1128/aac.00080-10
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 64.0 ug.mL-1 10.1128/aac.00110-10
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 64.0 ug.mL-1 10.1128/aac.00248-09
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 64.0 ug.mL-1 10.1128/aac.00341-08
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 64.0 ug.mL-1 10.1128/aac.00385-10
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 64.0 ug.mL-1 10.1128/aac.00574-09
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 64.0 ug.mL-1 10.1128/aac.00707-08
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 64.0 ug.mL-1 10.1128/aac.00816-09
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 64.0 ug.mL-1 10.1128/aac.00859-09
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 64.0 ug.mL-1 10.1128/aac.01360-08
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 64.0 ug.mL-1 10.1128/aac.01561-09
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 128.0 ug.mL-1 10.1128/aac.00248-09
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 128.0 ug.mL-1 10.1128/aac.00341-08
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 128.0 ug.mL-1 10.1128/aac.00574-09
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 128.0 ug.mL-1 10.1128/aac.01104-09
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 128.0 ug.mL-1 10.1128/aac.01360-08
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 128.0 ug.mL-1 10.1128/aac.01646-09
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 250.0 ug.mL-1 10.1128/aac.01617-08
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 256.0 ug.mL-1 10.1128/aac.00341-08
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 256.0 ug.mL-1 10.1128/aac.00900-09
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 256.0 ug.mL-1 10.1128/aac.01405-06
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 256.0 ug.mL-1 10.1128/aac.01451-07
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 256.0 ug.mL-1 10.1128/aac.01646-09
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 400.0 nM 10.1021/acs.jmedchem.7b01164
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 500.0 ug.mL-1 10.1128/aac.01617-08
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 512.0 ug.mL-1 10.1128/aac.00110-10
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 512.0 ug.mL-1 10.1128/aac.01646-09
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 750.0 ug.mL-1 10.1128/aac.01617-08
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 1000.0 ug.mL-1 10.1128/aac.01617-08
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 1500.0 ug.mL-1 10.1128/aac.01617-08
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 1600.0 nM 10.1021/acs.jmedchem.7b01164
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 3000.0 nM 10.1021/acs.jmedchem.7b01164
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 3000.0 ug.mL-1 10.1128/aac.01617-08
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 6000.0 nM 10.1021/acs.jmedchem.7b01164
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 6000.0 ug.mL-1 10.1128/aac.01617-08
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 8000.0 ug.mL-1 10.1128/aac.01617-08
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 12000.0 ug.mL-1 10.1128/aac.01617-08
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 12500.0 nM 10.1021/acs.jmedchem.7b01164
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 16000.0 ug.mL-1 10.1128/aac.01617-08
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 50000.0 nM 10.1021/acs.jmedchem.7b01164
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC nan None 10.1128/aac.00734-08
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC nan None 10.1128/aac.01024-08
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC50 2.0 ug.mL-1 10.1128/aac.00248-09
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC50 4.0 ug.mL-1 10.1128/aac.00248-09
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC50 4.0 ug.mL-1 10.1128/aac.00503-07
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC50 8.0 ug.mL-1 10.1021/acs.jmedchem.0c00255
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC50 8.0 ug.mL-1 10.1021/jm400560z
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC50 16.0 ug.mL-1 10.1021/ml200012f
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC50 16.0 ug.mL-1 10.1128/aac.01525-09
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC90 2.0 ug.mL-1 10.1016/j.bmcl.2012.07.005
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC90 16.0 ug.mL-1 10.1021/acs.jmedchem.0c00255
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC90 16.0 ug.mL-1 10.1021/jm400560z
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC90 16.0 ug.mL-1 10.1128/aac.00503-07
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC90 32.0 ug.mL-1 10.1016/j.bmcl.2012.07.005
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC90 32.0 ug.mL-1 10.1128/aac.01525-09
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC90 64.0 ug.mL-1 10.1021/jm2014748
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC90 64.0 ug.mL-1 10.1021/jm2014875
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC90 64.0 ug.mL-1 10.1021/jm400560z
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC90 64.0 ug.mL-1 10.1021/ml200012f
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC90 128.0 ug.mL-1 10.1128/aac.00248-09
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC90 1024.0 ug.mL-1 10.1021/acsmedchemlett.5b00026
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC90 1024.0 ug.mL-1 10.1021/jm501506f
Pseudomonas aeruginosa Pseudomonas aeruginosa PD50 50.0 mg kg-1 10.1021/ml200012f
Pseudomonas aeruginosa Pseudomonas aeruginosa PD50 200.0 mg kg-1 10.1021/ml200012f
Pseudomonas aeruginosa Pseudomonas aeruginosa Ratio 2.0 None 10.1128/aac.01617-08
Pseudomonas aeruginosa Pseudomonas aeruginosa Ratio 4.0 None 10.1128/aac.01617-08
Pseudomonas aeruginosa Pseudomonas aeruginosa TIME 0.4283 hr 10.1128/aac.00428-08
Pseudomonas aeruginosa Pseudomonas aeruginosa TIME 0.4333 hr 10.1128/aac.00428-08
Pseudomonas aeruginosa Pseudomonas aeruginosa TIME 0.455 hr 10.1128/aac.00428-08
Pseudomonas aeruginosa Pseudomonas aeruginosa TIME 0.4617 hr 10.1128/aac.00428-08
Pseudomonas aeruginosa Pseudomonas aeruginosa TIME 2.0 hr 10.1128/aac.00248-09
Pseudomonas aeruginosa Pseudomonas aeruginosa TIME 4.0 hr 10.1128/aac.00248-09
Pseudomonas aeruginosa Pseudomonas aeruginosa TIME 8.0 hr 10.1128/aac.00248-09
Pseudomonas aeruginosa Pseudomonas aeruginosa TIME 24.0 hr 10.1128/aac.00248-09
Pseudomonas aeruginosa PAO1 Penicillin-binding protein 1A IC50 3340.0 nM 10.1021/jm500219c
Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG12228) Beta-lactamase Kcat nan None 10.1128/aac.01410-08
Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG12228) Beta-lactamase Kcat/Km nan None 10.1128/aac.01410-08
Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG12228) Beta-lactamase Km nan None 10.1128/aac.01410-08
Pseudomonas fluorescens Beta-lactamase Kcat/Km 35.0 /mM/s 10.1128/aac.00961-09
Pseudomonas fluorescens Pseudomonas fluorescens MIC 256.0 ug.mL-1 10.1128/aac.00961-09
Pseudomonas luteola Beta-lactamase Kcat 1.5 /s 10.1128/aac.00427-09
Pseudomonas luteola Beta-lactamase Kcat/Km 0.04 /s/microM 10.1128/aac.00427-09
Pseudomonas luteola Beta-lactamase Km 40000.0 nM 10.1128/aac.00427-09
Pseudomonas putida Pseudomonas putida MIC 8.0 ug.mL-1 10.1128/aac.00707-08
Pseudomonas putida Pseudomonas putida MIC 16.0 ug.mL-1 10.1128/aac.00838-06
Pseudomonas stutzeri Metallo-beta-lactamase Kcat 0.01 /s 10.1128/aac.01456-09
Pseudomonas stutzeri Metallo-beta-lactamase Km nan None 10.1128/aac.01456-09
Pseudomonas stutzeri Metallo-beta-lactamase Ratio nan None 10.1128/aac.01456-09
Rattus norvegicus Aldose reductase IC50 nan None None
Rattus norvegicus Aldose reductase Ki nan None None
Rattus norvegicus Alpha-1a adrenergic receptor IC50 nan None None
Rattus norvegicus Alpha-1a adrenergic receptor Ki nan None None
Rattus norvegicus Alpha-1b adrenergic receptor IC50 nan None None
Rattus norvegicus Alpha-1b adrenergic receptor Ki nan None None
Rattus norvegicus Androgen Receptor AC50 400000.0 nM 10.1038/s41467-023-40064-9
Rattus norvegicus Androgen Receptor IC50 nan None None
Rattus norvegicus Androgen Receptor Ki nan None None
Rattus norvegicus Cyclooxygenase-1 AC50 400000.0 nM 10.1038/s41467-023-40064-9
Rattus norvegicus GABA receptor alpha-1 subunit AC50 400000.0 nM 10.1038/s41467-023-40064-9
Rattus norvegicus Glycine receptor IC50 nan None None
Rattus norvegicus Glycine receptor Ki nan None None
Rattus norvegicus Insulin receptor IC50 nan None None
Rattus norvegicus Insulin receptor Ki nan None None
Rattus norvegicus Nitric-oxide synthase, brain IC50 nan None None
Rattus norvegicus Nitric-oxide synthase, brain Ki nan None None
Rattus norvegicus Plasma Fu 0.4 None 10.1021/jm901371v
Rattus norvegicus Plasma logFu 0.44 None 10.1016/j.ejmech.2009.06.004
Rattus norvegicus Rattus norvegicus Activity nan None 10.1016/j.bmc.2007.07.039
Rattus norvegicus Rattus norvegicus ALB 40300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALB 42700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALB 43800.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALB 45000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 336.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 346.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 364.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 398.83 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALT 43.83 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALT 46.5 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALT 47.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALT 52.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AST 72.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AST 76.5 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AST 79.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AST 81.17 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AUC 13000.0 ng.hr.mL-1 10.1016/j.bmcl.2018.01.006
Rattus norvegicus Rattus norvegicus BASO 0.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BASOLE 0.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BILI 1.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BILI 1.5 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BILI 1.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BILI 2.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BUN 160.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BUN 163.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BUN 176.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BUN 200.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHLORIDE 99.17 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHLORIDE 100.33 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHLORIDE 101.0 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHLORIDE 102.33 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 650.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 713.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 720.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 740.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CK 183.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CK 231.83 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CK 274.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CK 331.5 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CL 13.0 mL.min-1.kg-1 10.1016/j.bmcl.2018.01.006
Rattus norvegicus Rattus norvegicus CL 21.0 mL.min-1.kg-1 10.1021/jm501506f
Rattus norvegicus Rattus norvegicus CO2 27000000.0 nM 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CO2 27500000.0 nM 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CREAT 1.8 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CREAT 2.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CREAT 3.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus Drugexcretion 40.0 %ID 10.1016/j.bmcl.2018.01.006
Rattus norvegicus Rattus norvegicus EOS 113.67 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOS 148.67 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOS 222.83 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOS 309.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOSLE 1.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOSLE 1.33 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOSLE 1.67 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus GLUC 1676.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus GLUC 1688.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus GLUC 1713.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus GLUC 1766.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 34.77 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 35.77 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 35.83 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 36.52 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HGB 129700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HGB 134000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HGB 134500.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HGB 135000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LDH 74.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LDH 90.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LDH 174.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LDH 241.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LIPASE 8.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LIPASE 9.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LIPASE 9.5 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYM 10636.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYM 13777.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYM 14453.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYM 16020.5 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYMLE 87.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYMLE 89.33 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYMLE 90.5 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYMLE 91.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCH 23.22 pg 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCH 23.37 pg 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCH 24.4 pg 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 368500.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 373000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 374700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 377000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 61.92 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 61.93 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 63.47 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 65.27 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONO 0.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONO 29.17 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONO 74.67 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONOLE 0.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONOLE 0.17 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONOLE 0.67 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTLE 7.33 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTLE 8.33 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTLE 9.33 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTLE 11.33 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTSG 842.33 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTSG 1468.33 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTSG 1490.83 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTSG 1914.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOS 111.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOS 114.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOS 114.8 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOS 122.5 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 1184330.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 1239500.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 1255500.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 1394000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 5.8 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 6.11 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 6.33 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 6.82 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PROT 55300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PROT 59800.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PROT 60000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBC 5330000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBC 5760000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBC 5780000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBCNUC 0.0 /100WBC 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBCNUC 0.17 /100WBC 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBCNUC 0.33 /100WBC 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus SODIUM 141.28 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus SODIUM 142.4 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus SODIUM 143.8 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus SODIUM 146.47 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus T1/2 0.3 hr 10.1021/jm501506f
Rattus norvegicus Rattus norvegicus T1/2 0.5 hr 10.1016/j.bmcl.2018.01.006
Rattus norvegicus Rattus norvegicus URATE 16.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus URATE 16.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus URATE 17.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus URATE 18.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus Vd 0.3 L.kg-1 10.1016/j.bmcl.2018.01.006
Rattus norvegicus Rattus norvegicus Vdss 0.44 L.kg-1 10.1021/jm501506f
Rattus norvegicus Rattus norvegicus WBC 11670.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WBC 16000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WBC 16170.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WBC 17670.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Serotonin 1a (5-HT1a) receptor IC50 nan None None
Rattus norvegicus Serotonin 1a (5-HT1a) receptor Ki nan None None
Rattus norvegicus Serotonin 1b (5-HT1b) receptor IC50 nan None None
Rattus norvegicus Serotonin 1b (5-HT1b) receptor Ki nan None None
Salmonella enterica Salmonella enterica MIC 64.0 ug.mL-1 10.1128/aac.01790-09
Salmonella enterica subsp. enterica serovar Typhi Salmonella typhi MIC 0.03 ug.mL-1 10.1016/j.ejmech.2016.01.024
Salmonella enterica subsp. enterica serovar Typhimurium Salmonella typhimurium MIC 100.0 nM 10.1021/acs.jmedchem.7b01164
Salmonella enterica subsp. enterica serovar Westhampton Extended-spectrum beta-lactamase CTX-M-53 Kcat 4.0 /s 10.1128/aac.01581-08
Salmonella enterica subsp. enterica serovar Westhampton Extended-spectrum beta-lactamase CTX-M-53 Kcat/Km 0.3 /s/microM 10.1128/aac.01581-08
Salmonella enterica subsp. enterica serovar Westhampton Extended-spectrum beta-lactamase CTX-M-53 Km 14000.0 nM 10.1128/aac.01581-08
Salmonella newport Efflux transporter IC50 6.0 nM 10.1128/aac.01284-08
Serratia fonticola Carbapenem-hydrolizing beta-lactamase SFC-1 Kcat 162.0 /s 10.1128/aac.00491-07
Serratia fonticola Carbapenem-hydrolizing beta-lactamase SFC-1 Kcat/Km 334.7 /mM/s 10.1128/aac.00491-07
Serratia fonticola Carbapenem-hydrolizing beta-lactamase SFC-1 Km 484000.0 nM 10.1128/aac.00491-07
Serratia marcescens Serratia marcescens MIC 0.06 ug.mL-1 10.1021/jm00128a014
Serratia marcescens Serratia marcescens MIC 0.12 ug.mL-1 10.1021/jm00128a014
Serratia marcescens Serratia marcescens MIC 0.125 ug.mL-1 10.1016/j.ejmech.2016.01.024
Serratia marcescens Serratia marcescens MIC 0.25 ug.mL-1 10.1021/jm00128a014
Serratia marcescens Serratia marcescens MIC 1.0 ug.mL-1 10.1128/aac.01634-07
Serratia marcescens Serratia marcescens MIC 8.0 ug.mL-1 10.1128/aac.00768-10
Serratia marcescens Serratia marcescens MIC 8.0 ug.mL-1 10.1128/aac.01525-09
Serratia marcescens Serratia marcescens MIC 16.0 ug.mL-1 10.1128/aac.01525-09
Serratia marcescens Serratia marcescens MIC 64.0 ug.mL-1 10.1128/aac.00768-10
Serratia marcescens Serratia marcescens MIC 64.0 ug.mL-1 10.1128/aac.01028-07
Serratia marcescens Serratia marcescens MIC 128.0 ug.mL-1 10.1128/aac.01539-07
Serratia marcescens Serratia marcescens MIC50 0.5 ug.mL-1 10.1021/ml200012f
Serratia marcescens Serratia marcescens MIC90 64.0 ug.mL-1 10.1021/ml200012f
Severe acute respiratory syndrome coronavirus 2 Replicase polyprotein 1ab Inhibition 4.61 % 10.6019/CHEMBL4495564
Severe acute respiratory syndrome coronavirus 2 Replicase polyprotein 1ab Inhibition 7.203 % 10.6019/CHEMBL4495564
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Hit score 0.135 None 10.1101/2020.04.21.054387
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 IC50 19952.62 nM 10.6019/CHEMBL4651402
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 IC50 20000.0 nM 10.6019/CHEMBL4651402
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Inhibition -0.06 % 10.6019/CHEMBL4495565
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Inhibition 0.11 % 10.6019/CHEMBL4495565
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Inhibition 1.89 % 10.21203/rs.3.rs-23951/v1
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Inhibition index 0.1281 None 10.1101/2020.04.03.023846
Shigella sonnei Shigella sonnei MIC 32.0 ug.mL-1 10.1128/aac.00227-08
Shouchella clausii Shouchella clausii Activity nan None 10.1128/aac.00537-07
Shouchella clausii Shouchella clausii MIC 512000.0 ug.mL-1 10.1128/aac.00537-07
Staphylococcus aureus Staphylococcus aureus MIC 64.0 ug.mL-1 10.1128/aac.01790-09
Staphylococcus aureus Staphylococcus aureus MIC 50000.0 nM 10.1021/acs.jmedchem.7b01164
Staphylococcus aureus Staphylococcus aureus MIC50 128.0 ug.mL-1 10.1128/aac.00248-09
Staphylococcus aureus Staphylococcus aureus MIC50 512.0 ug.mL-1 10.1128/aac.00248-09
Staphylococcus aureus Staphylococcus aureus MIC90 128.0 ug.mL-1 10.1128/aac.00248-09
Staphylococcus aureus Staphylococcus aureus MIC90 512.0 ug.mL-1 10.1128/aac.00248-09
Stenotrophomonas maltophilia Beta-lactamase L1 Kcat/Km nan None 10.1128/aac.01062-07
Stenotrophomonas maltophilia Stenotrophomonas maltophilia Activity nan None 10.1128/aac.00682-07
Stenotrophomonas maltophilia Stenotrophomonas maltophilia MIC 16.0 ug.mL-1 10.1128/aac.00682-07
Stenotrophomonas maltophilia Stenotrophomonas maltophilia MIC 16.0 ug.mL-1 10.1128/aac.01283-09
Stenotrophomonas maltophilia Stenotrophomonas maltophilia MIC 32.0 ug.mL-1 10.1128/aac.01283-09
Stenotrophomonas maltophilia Stenotrophomonas maltophilia MIC 32.0 ug.mL-1 10.1128/aac.01525-09
Stenotrophomonas maltophilia Stenotrophomonas maltophilia MIC 1024.0 ug.mL-1 10.1128/aac.01283-09
Stenotrophomonas maltophilia Stenotrophomonas maltophilia MIC 2048.0 ug.mL-1 10.1128/aac.00682-07
Stenotrophomonas maltophilia Stenotrophomonas maltophilia MIC 2048.0 ug.mL-1 10.1128/aac.01513-08
Stenotrophomonas maltophilia Stenotrophomonas maltophilia MIC50 64.0 ug.mL-1 10.1021/ml200012f
Stenotrophomonas maltophilia Stenotrophomonas maltophilia MIC50 128.0 ug.mL-1 10.1128/aac.00248-09
Stenotrophomonas maltophilia Stenotrophomonas maltophilia MIC90 64.0 ug.mL-1 10.1021/ml200012f
Stenotrophomonas maltophilia Stenotrophomonas maltophilia MIC90 128.0 ug.mL-1 10.1128/aac.00248-09
Stenotrophomonas maltophilia Stenotrophomonas maltophilia Ratio 7.9 None 10.1128/aac.00682-07
Streptococcus pyogenes Streptococcus pyogenes MIC nan ug.mL-1 10.1016/S0960-894X(01)80932-X
Stutzerimonas stutzeri Stutzerimonas stutzeri MIC 2.0 ug.mL-1 10.1128/aac.01456-09
None ADMET CL 1.3 mL.min-1.kg-1 10.1002/jps.20373
None ADMET CL 1.5 mL.min-1.kg-1 10.1124/dmd.108.020479
None ADMET CL 5.0 mL.min-1.kg-1 10.1002/jps.20373
None ADMET CL 8.0 mL.min-1.kg-1 10.1002/jps.20373
None ADMET CL 11.0 mL.min-1.kg-1 10.1002/jps.20373
None ADMET Drugexcretion 68.0 % 10.1016/j.ejmech.2020.112829
None ADMET Drug metabolism 1.0 % 10.1016/j.ejmech.2020.112829
None ADMET F 1.0 % 10.1016/j.ejmech.2020.112829
None ADMET F 1.0 % 10.1021/acsmedchemlett.9b00534
None ADMET F 100.0 % 10.1016/j.ejmech.2020.112829
None ADMET k 0.4 hr-1 10.1021/jm00386a015
None ADMET k 0.4 hr-1 10.1021/jm00401a026
None ADMET log10(%HIA +10) 1.041 None 10.1016/j.ejmech.2010.11.005
None ADMET MRT 2.1 hr 10.1124/dmd.108.020479
None ADMET PPB 15.0 % 10.1016/j.bmcl.2018.01.006
None ADMET PPB 34.0 % 10.1016/j.bmcl.2018.01.006
None ADMET PPB 73.0 % 10.1016/j.bmcl.2018.01.006
None ADMET PPB 76.0 % 10.1016/j.bmcl.2018.01.006
None ADMET PPB 81.71 % 10.6019/CHEMBL3301361
None ADMET T1/2 1.5 hr 10.1124/dmd.108.020479
None ADMET T1/2 1.6 hr 10.1016/j.ejmech.2020.112829
None ADMET T1/2 1.7 hr 10.1021/jm00386a015
None ADMET T1/2 150.0 hr 10.1021/jm501506f
None ADMET Vdss 0.17 L.kg-1 10.1002/jps.20373
None ADMET Vdss 0.18 L.kg-1 10.1124/dmd.108.020479
None ADMET Vdss 0.3 L.kg-1 10.1002/jps.20373
None ADMET Vdss 0.32 mL/min/kg 10.1002/jps.20373
None ADMET Vdss 0.66 L.kg-1 10.1002/jps.20373
None Hepatotoxicity Alkaline Phosphatase Increase - Activity Score nan None 10.2174/1570163043334794
None Hepatotoxicity Alkaline Phosphatase Increase - Index Value 6.9 None 10.2174/1570163043334794
None Hepatotoxicity Alkaline Phosphatase Increase - Number of Reports 4.0 None 10.2174/1570163043334794
None Hepatotoxicity Composite Activity - Active 1.0 None 10.2174/1570163043334794
None Hepatotoxicity Composite Activity - Marginal 2.0 None 10.2174/1570163043334794
None Hepatotoxicity Composite Activity - Score nan None 10.2174/1570163043334794
None Hepatotoxicity GGT Increase - Activity Score nan None 10.2174/1570163043334794
None Hepatotoxicity GGT Increase - Index Value 0.6 None 10.2174/1570163043334794
None Hepatotoxicity GGT Increase - Number of Reports 4.0 None 10.2174/1570163043334794
None Hepatotoxicity Hepatotoxicity nan None 10.1021/tx1000865
None Hepatotoxicity Hepatotoxicity nan None 10.1021/tx900326k
None Hepatotoxicity Hepatotoxicity nan None 10.1124/dmd.110.035113
None Hepatotoxicity HepSE_bilirubinemia 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_cholecystitis 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_cholelithiasis 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_cirrhosis 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_Combined Scores 2.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_elevated liver function tests 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_hepatic failure 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_hepatic necrosis 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_hepatitis 1.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_hepatomegaly 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_jaundice 1.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_liver disease 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_liver fatty 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_liver function tests abnormal 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity LDH Increase - Activity Score nan None 10.2174/1570163043334794
None Hepatotoxicity LDH Increase - Index Value 0.6 None 10.2174/1570163043334794
None Hepatotoxicity LDH Increase - Number of Reports 4.0 None 10.2174/1570163043334794
None Hepatotoxicity SGOT Increase - Activity Score nan None 10.2174/1570163043334794
None Hepatotoxicity SGOT Increase - Index Value 3.2 None 10.2174/1570163043334794
None Hepatotoxicity SGOT Increase - Number of Reports 4.0 None 10.2174/1570163043334794
None Hepatotoxicity SGPT Increase - Activity Score nan None 10.2174/1570163043334794
None Hepatotoxicity SGPT Increase - Index Value 3.8 None 10.2174/1570163043334794
None Hepatotoxicity SGPT Increase - Number of Reports 4.0 None 10.2174/1570163043334794
None Molecular identity unknown Fu 0.6 None 10.1021/jm501506f
None NON-PROTEIN TARGET Fu 0.4 None 10.1124/dmd.108.020479
None NON-PROTEIN TARGET Hepatotoxicity (acute) 0.0 % 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (animal toxicity known) nan None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (benign tumour) 0.0 None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (granulomatous hepatitis) 0.0 None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (mechanism) nan None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (moderate) 60.0 % 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (moderate) 104.0 None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (time to onset) nan None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET MIC 0.016 ug.mL-1 10.1128/aac.01252-09
None NON-PROTEIN TARGET MIC 0.016 ug.mL-1 10.1128/aac.01615-09
None NON-PROTEIN TARGET MIC 0.06 ug.mL-1 10.1128/aac.00978-07
None NON-PROTEIN TARGET MIC 0.06 ug.mL-1 10.1128/aac.01152-06
None NON-PROTEIN TARGET MIC 0.12 ug.mL-1 10.1128/aac.00978-07
None NON-PROTEIN TARGET MIC 0.125 ug.mL-1 10.1128/aac.00791-09
None NON-PROTEIN TARGET MIC 0.125 ug.mL-1 10.1128/aac.01252-09
None NON-PROTEIN TARGET MIC 1.0 ug.mL-1 10.1128/aac.00684-07
None NON-PROTEIN TARGET MIC 1.0 ug.mL-1 10.1128/aac.01585-09
None NON-PROTEIN TARGET MIC 1.0 ug.mL-1 10.1128/aac.01634-07
None NON-PROTEIN TARGET MIC 2.0 ug.mL-1 10.1128/aac.00427-09
None NON-PROTEIN TARGET MIC 4.0 ug.mL-1 10.1128/aac.00427-09
None NON-PROTEIN TARGET MIC 64.0 ug.mL-1 10.1128/aac.00734-08
None NON-PROTEIN TARGET MIC 64.0 ug.mL-1 10.1128/aac.01463-07
None NON-PROTEIN TARGET MIC 128.0 ug.mL-1 10.1016/S0960-894X(01)80932-X
None NON-PROTEIN TARGET MIC 256.0 ug.mL-1 10.1128/aac.01581-08
None NON-PROTEIN TARGET MIC 512.0 ug.mL-1 10.1128/aac.01600-06
None NON-PROTEIN TARGET MIC50 64.0 ug.mL-1 10.1128/aac.00248-09
None NON-PROTEIN TARGET MIC90 128.0 ug.mL-1 10.1128/aac.00248-09
None No relevant target pKa 2.75 None 10.1016/j.ejmech.2009.06.004
None No relevant target T1/2 150.0 hr 10.1021/acsmedchemlett.5b00026
None No relevant target T1/2 2000.0 hr 10.1016/j.bmcl.2018.01.006
None Nucleic Acid Ratio 0.2 None 10.1021/ml200012f
None Unchecked Activity 0.01 % 10.1128/aac.01164-08
None Unchecked Activity 0.016 % 10.1128/aac.00175-08
None Unchecked Activity 0.12 % 10.1128/aac.00175-08
None Unchecked Activity nan None 10.1128/aac.00083-07
None Unchecked Activity nan None 10.1128/aac.00175-08
None Unchecked Activity nan None 10.1128/aac.00219-09
None Unchecked Activity nan None 10.1128/aac.01145-07
None Unchecked Hepatotoxicity (acute) 1.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (association with vascular disease) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (choleostasis) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (chronic liver disease) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (cirrhosis) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (comment) nan None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (cytolytic) 1.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (malignant tumour) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (severe hepatitis) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (steatosis) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (successful reintroduction) nan None 10.1016/s0399-8320(04)95062-2
None Unchecked IC50 0.02 ug.mL-1 10.1128/aac.01529-07
None Unchecked IC50 0.03 ug.mL-1 10.1128/aac.00029-07
None Unchecked IC50 0.03 ug.mL-1 10.1128/aac.01529-07
None Unchecked IC50 2.0 ug.mL-1 10.1128/aac.00029-07
None Unchecked IC50 2.0 ug.mL-1 10.1128/aac.01529-07
None Unchecked IC50 4.0 ug.mL-1 10.1128/aac.01529-07
None Unchecked IC50 6.0 nM 10.1128/aac.01284-08
None Unchecked IC50 8.0 nM 10.1021/jm400560z
None Unchecked IC50 8.0 nM 10.1021/jm500219c
None Unchecked IC50 8.0 ug.mL-1 10.1128/aac.00029-07
None Unchecked IC50 8.0 ug.mL-1 10.1128/aac.01529-07
None Unchecked IC50 16.0 ug.mL-1 10.1128/aac.00029-07
None Unchecked IC50 16.0 ug.mL-1 10.1128/aac.01529-07
None Unchecked IC50 23.0 nM 10.1128/aac.01525-09
None Unchecked IC50 2870.0 nM 10.1021/jm400560z
None Unchecked IC50 2870.0 nM 10.1021/jm500219c
None Unchecked IC50 3340.0 nM 10.1021/jm400560z
None Unchecked IC50 50000.0 nM 10.1128/aac.01525-09
None Unchecked IC50 300000.0 nM 10.1021/jm400560z
None Unchecked IC50 300000.0 nM 10.1021/jm500219c
None Unchecked IC50 1100000.0 nM 10.1128/aac.01525-09
None Unchecked IC50 2500000.0 nM 10.1128/aac.01525-09
None Unchecked IC50 nan None None
None Unchecked Inhibition nan % 10.1128/aac.01821-09
None Unchecked K 2.6 10'5/M/s 10.1021/acsmedchemlett.5b00026
None Unchecked Kcat 0.01 /s 10.1128/aac.00166-08
None Unchecked Kcat 0.01 /s 10.1128/aac.00387-08
None Unchecked Kcat 0.01 /s 10.1128/aac.00774-09
None Unchecked Kcat 0.01 /s 10.1128/aac.00856-09
None Unchecked Kcat 0.01 /s 10.1128/aac.00858-10
None Unchecked Kcat 0.01 /s 10.1128/aac.01164-08
None Unchecked Kcat 0.01 /s 10.1128/aac.01600-06
None Unchecked Kcat 0.031 /s 10.1128/aac.00175-08
None Unchecked Kcat 0.1 /s 10.1128/aac.00017-09
None Unchecked Kcat 0.1 /s 10.1128/aac.00614-07
None Unchecked Kcat 0.1 /s 10.1128/aac.01058-06
None Unchecked Kcat 0.11 /s 10.1128/aac.00175-08
None Unchecked Kcat 2.0 /s 10.1128/aac.00614-07
None Unchecked Kcat 2.0 /s 10.1128/aac.01028-07
None Unchecked Kcat 2.1 /s 10.1128/aac.01058-06
None Unchecked Kcat 3.0 /s 10.1128/aac.00163-08
None Unchecked Kcat 3.5 /s 10.1128/aac.01058-06
None Unchecked Kcat 3.6 /s 10.1128/aac.01028-07
None Unchecked Kcat 4.5 /s 10.1128/aac.00098-10
None Unchecked Kcat 4.7 /s 10.1128/aac.01028-07
None Unchecked Kcat 6.6 /s 10.1128/aac.00098-10
None Unchecked Kcat 6.7 /s 10.1128/aac.00098-10
None Unchecked Kcat 8.3 /s 10.1128/aac.01058-06
None Unchecked Kcat 8.6 /s 10.1128/aac.00098-10
None Unchecked Kcat 9.1 /s 10.1128/aac.00098-10
None Unchecked Kcat 12.0 /s 10.1128/aac.00098-10
None Unchecked Kcat 15.0 /s 10.1128/aac.00098-10
None Unchecked Kcat 35.0 /s 10.1128/aac.00961-09
None Unchecked Kcat 35.6 /s 10.1128/aac.00771-10
None Unchecked Kcat 43.0 /s 10.1128/aac.01058-06
None Unchecked Kcat 45.5 /s 10.1128/aac.00771-10
None Unchecked Kcat 51.0 /s 10.1128/aac.01525-09
None Unchecked Kcat nan None 10.1128/aac.00098-10
None Unchecked Kcat nan None 10.1128/aac.00771-10
None Unchecked Kcat nan None 10.1128/aac.01062-07
None Unchecked Kcat nan None 10.1128/aac.01252-09
None Unchecked Kcat nan None 10.1128/aac.01337-07
None Unchecked Kcat nan None 10.1128/aac.01410-08
None Unchecked Kcat nan None 10.1128/aac.01442-09
None Unchecked Kcat nan None 10.1128/aac.01525-09
None Unchecked Kcat/Km 0.0001 /s/microM 10.1128/aac.00774-09
None Unchecked Kcat/Km 0.002 /M/s 10.1128/aac.01525-09
None Unchecked Kcat/Km 0.008 None 10.1128/aac.00614-07
None Unchecked Kcat/Km 0.06 /uM/s 10.1128/aac.01058-06
None Unchecked Kcat/Km 0.07 /uM/s 10.1128/aac.01028-07
None Unchecked Kcat/Km 0.09 /uM/s 10.1128/aac.00771-10
None Unchecked Kcat/Km 0.092 /uM/s 10.1128/aac.01028-07
None Unchecked Kcat/Km 0.1 /uM/s 10.1128/aac.01058-06
None Unchecked Kcat/Km 0.13 /uM/s 10.1128/aac.01028-07
None Unchecked Kcat/Km 0.16 /uM/s 10.1128/aac.01058-06
None Unchecked Kcat/Km 0.19 /uM/s 10.1128/aac.00771-10
None Unchecked Kcat/Km 0.57 /uM/s 10.1128/aac.01058-06
None Unchecked Kcat/Km 1.0 10'2 uM/s 10.1128/aac.00166-08
None Unchecked Kcat/Km 1.1 10'5/s/M 10.1128/aac.00098-10
None Unchecked Kcat/Km 1.3 10'5/s/M 10.1128/aac.00098-10
None Unchecked Kcat/Km 1.5 10'5/s/M 10.1128/aac.00098-10
None Unchecked Kcat/Km 1.9 10'4/s/M 10.1128/aac.00098-10
None Unchecked Kcat/Km 2.9 10'5/s/M 10.1128/aac.00098-10
None Unchecked Kcat/Km 3.5 10'4/s/M 10.1128/aac.00098-10
None Unchecked Kcat/Km 7.7 10'4/s/M 10.1128/aac.00098-10
None Unchecked Kcat/Km 9.6 10'4/s/M 10.1128/aac.00098-10
None Unchecked Kcat/Km 120.0 /uM/s 10.1128/aac.01585-09
None Unchecked Kcat/Km 500.0 /uM/s 10.1128/aac.00163-08
None Unchecked Kcat/Km 900.0 /mM/s 10.1128/aac.00961-09
None Unchecked Kcat/Km 97000.0 /M/s 10.1128/aac.01525-09
None Unchecked Kcat/Km nan None 10.1128/aac.00050-10
None Unchecked Kcat/Km nan None 10.1128/aac.00083-07
None Unchecked Kcat/Km nan None 10.1128/aac.00175-08
None Unchecked Kcat/Km nan None 10.1128/aac.00387-08
None Unchecked Kcat/Km nan None 10.1128/aac.00614-07
None Unchecked Kcat/Km nan None 10.1128/aac.00771-10
None Unchecked Kcat/Km nan None 10.1128/aac.01062-07
None Unchecked Kcat/Km nan None 10.1128/aac.01082-06
None Unchecked Kcat/Km nan None 10.1128/aac.01410-08
None Unchecked Kcat/Km nan None 10.1128/aac.01442-09
None Unchecked Kcat/Km nan None 10.1128/aac.01525-09
None Unchecked Ki 1.0 nM 10.1128/aac.01009-09
None Unchecked Ki 2.1 nM 10.1128/aac.00219-09
None Unchecked Ki 17.0 nM 10.1128/aac.00219-09
None Unchecked Ki nan None None
None Unchecked Kinact 2.6 10'5/M/s 10.1021/jm501506f
None Unchecked Km 247.0 /s/microM 10.1128/aac.00614-07
None Unchecked Km 11000.0 nM 10.1128/aac.01581-08
None Unchecked Km 22000.0 nM 10.1128/aac.01058-06
None Unchecked Km 27000.0 nM 10.1128/aac.01028-07
None Unchecked Km 28000.0 nM 10.1128/aac.01028-07
None Unchecked Km 31000.0 nM 10.1128/aac.00098-10
None Unchecked Km 34000.0 nM 10.1128/aac.01058-06
None Unchecked Km 35000.0 nM 10.1128/aac.00163-08
None Unchecked Km 51000.0 nM 10.1128/aac.01028-07
None Unchecked Km 58000.0 nM 10.1128/aac.00098-10
None Unchecked Km 64000.0 nM 10.1128/aac.00098-10
None Unchecked Km 69000.0 nM 10.1128/aac.00098-10
None Unchecked Km 75000.0 nM 10.1128/aac.01058-06
None Unchecked Km 83000.0 nM 10.1128/aac.01058-06
None Unchecked Km 93000.0 nM 10.1128/aac.00098-10
None Unchecked Km 100000.0 nM 10.1128/aac.00098-10
None Unchecked Km 240000.0 nM 10.1128/aac.00098-10
None Unchecked Km 241000.0 nM 10.1128/aac.00771-10
None Unchecked Km 405000.0 nM 10.1128/aac.00771-10
None Unchecked Km 500000.0 nM 10.1128/aac.01252-09
None Unchecked Km 530000.0 nM 10.1128/aac.01525-09
None Unchecked Km 1000000.0 nM 10.1128/aac.00166-08
None Unchecked Km 1000000.0 nM 10.1128/aac.00774-09
None Unchecked Km 1000000.0 nM 10.1128/aac.00858-10
None Unchecked Km 1000000.0 nM 10.1128/aac.00961-09
None Unchecked Km nan None 10.1128/aac.00098-10
None Unchecked Km nan None 10.1128/aac.00175-08
None Unchecked Km nan None 10.1128/aac.00387-08
None Unchecked Km nan None 10.1128/aac.00614-07
None Unchecked Km nan None 10.1128/aac.00771-10
None Unchecked Km nan None 10.1128/aac.00856-09
None Unchecked Km nan None 10.1128/aac.01058-06
None Unchecked Km nan None 10.1128/aac.01062-07
None Unchecked Km nan None 10.1128/aac.01082-06
None Unchecked Km nan None 10.1128/aac.01164-08
None Unchecked Km nan None 10.1128/aac.01337-07
None Unchecked Km nan None 10.1128/aac.01410-08
None Unchecked Km nan None 10.1128/aac.01442-09
None Unchecked Km nan None 10.1128/aac.01525-09
None Unchecked Km nan None 10.1128/aac.01600-06
None Unchecked MIC 0.002 ug.mL-1 10.1021/jm00128a014
None Unchecked MIC 50000.0 nM 10.1021/acs.jmedchem.7b01164
None Unchecked Ratio 4.0 None 10.1128/aac.00614-07
None Unchecked Ratio nan None 10.1128/aac.01337-07
None Unchecked Stability nan % 10.1016/j.bmcl.2018.01.006

Metabolism Information

AKRT ID Reaction Reaction Link ID
AKRT014143 C[C@H]1[C@H](NC(=O)/C(=N\OC(C)(C)C(=O)O)c2csc(N)n2)C(=O)N1S(=O)(=O)O>>C[C@H](NS(=O)(=O)O)[C@H](NC(=O)/C(=N\OC(C)(C)C(=O)O)c1csc(N)n1)C(=O)O enzymemap_78568